Delayed bone healing by collagen membrane in early phase of four weeks

Publication date: Available online 20 July 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Jungtae Lee, Dajung Lee, Seo-Eun Oh, Kyeong-Mee Park, Sungtae Kim

Abstract

Objective

Barrier membranes are important in maintaining a space for the epithelium or connective tissues to grow in guided bone regeneration procedure. In this study, the effects of resorbable membranes during the early stages of bone regeneration and in subjects with impaired bone healing capacity were investigated.

Study Design

Twenty-eight rats were selected for this study. Half of all animals were selected for radiation therapy before surgical procedure. Four groups were assigned (G1∼G4). One circular defect was created in the center parietal bones. This was covered with resorbable membrane in group G2, G4. After 4 weeks, the animals were sacrificed.

Results

At week 4, the new bone formation was observed in the margins of old bone boundaries in the all groups except G3. Osteoclast was the most abundant in the G1 group (18.3±7.7) and the least in the G4 group (7.9±4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Runx2 levels were only significant difference in the G4 group when compared before and after treatment.

Conclusions

Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.

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