Genes important for otoneurological diagnostic purposes - current status and future prospects.

Genes important for otoneurological diagnostic purposes - current status and future prospects.

Acta Otorhinolaryngol Ital. 2018 Jun;38(3):242-250

Authors: Pawlak-Osiñska K, Linkowska K, Grzybowski T

Abstract
SUMMARY: This review focuses on the current knowledge of the genes responsible for non-syndromic hearing loss that can be useful for otoneurological diagnostic purposes. From among a large number of genes that have been associated with non-syndromic hearing impairment, we selected several best-known genes, including the COCH gene, GJB2, GJB6 and SLC26A4, and we describe their role and effects of mutations and prevalence of mutations in various populations. Next, we focus on genes associated with tinnitus. Important areas for further research include assessment of genes potentially involved in pathophysiology of tinnitus and vertigo, which have traditionally been considered as being of otological aetiology, while advances in neuroimaging techniques have increasingly shifted studies toward neurological correlations.

PMID: 29984802 [PubMed - in process]

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