Proton beam therapy for ameloblastic carcinoma of the maxilla: report of a rare case

Publication date: Available online 24 August 2018

Source: Journal of Oral and Maxillofacial Surgery

Author(s): Kenji Yamagata, Hitoshi Ishikawa, Takashi Saito, Hiroki Bukawa

Abstract

Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor that combines the histological features of ameloblastoma with cytological atypia. The standard treatment for this lesion is wide local excision. Proton beam therapy (PBT), which can deliver high irradiation doses to target while avoiding irradiation to surrounding normal tissues but no reports of PBT for AC have been published so far. We here report a case of a 70-year-old woman with a pathological diagnosis of maxillary AC who refused surgical resection, and received hypofractionated PBT at a total dose of 69 Gy in 23 fractions. She is still alive for more than 5 years after PBT without any evidences of recurrence and side effects. This is the first successful treatment case after curative radiation therapy for maxillary AC.

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