Benign and Malignant Odontogenic Neoplasms of the Jaws Show a Concordant Non-Discriminatory p63/p40 Positive Immunophenotype

Publication date: Available online 5 September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Prokopios P. Argyris, Chris Malz, Reda Taleb, Ioannis G. Koutlas

Abstract

Objectives

Antibody p40 which recognizes exclusively ΔNp63 but not TAp63, has shown diagnostic utility in salivary gland and sinonasal tract malignancies. Although p63 immunophenotypic characterization of odontogenic lesions has been reported, p40 expression has not been previously studied. We aimed to study p40 immunoreactivity in odontogenic tumors (OT) and cysts (OC), and to investigate possible discriminatory properties of the combined p63/p40 immunoprofile in OT and OC.

Study Design

Fourteen ameloblastomas (AME), 7 adenomatoid odontogenic tumors (AOT), 6 calcifying epithelial odontogenic tumors (CEOT), 1 squamous odontogenic tumor (SOT), 4 primary intraosseous odontogenic carcinomas (PIOC), 5 calcifying odontogenic cysts (COC), 4 glandular odontogenic cysts (GOC), 3 odontogenic keratocysts (OKC), 3 dentigerous cysts and 1 each radicular and orthokeratinized cysts were stained for p63 (4A4) and p40 (BC28) antibodies.

Results

AME, AOT, CEOT, SOT and PIOC demonstrated concordant p63+/p40+ immunophenotype. P40, similar to p63, highlighted almost all lesional cells of OT and, overall, the full thickness of the epithelial lining of OC and AME cystic areas. The keratin layer of OKC and adluminal ductal and mucous cells of GOC were p63-/p40-.

Conclusions

1) Both ΔNp63 and TAp63 isoforms are present in neoplastic and developmental odontogenic lesions; 2) p63/p40 immunophenotype is non-discriminatory pertaining to benign and malignant OT and OC.

https://ift.tt/2wEHweE