Leptin levels in the synovial fluid of patients with temporomandibular disorders

Publication date: Available online 20 September 2018

Source: Journal of Oral and Maxillofacial Surgery

Author(s): Haofei Xiong, Wei Li, Jin Ke, Wei Fang, Bo Li, Lili Wei

Purpose

This study was conducted to measure the concentrations of leptin and IL-6 in the synovial fluid (SF) of 38 patients with temporomandibular disorders (TMD) and 7 healthy controls, and analyze the correlation between leptin and IL-6.

Patients and Methods

Patients with TMD were divided into three subgroups according to imaging and clinical findings: displaced disc with reduction (DDR, n=12), displaced disc without reduction (DDNR, n=13), and osteoarthritis (OA, n=13). SF samples were collected, and leptin and IL-6 levels were measured by ELISA.

Results

No significant difference in leptin level was found between the control group and the DDR or DDNR group, whereas the OA group presented a higher leptin concentration than all other groups. IL-6 concentrations were significantly higher in all patient groups than in the control group. The levels were significantly higher in the OA group than in the DDR or DDNR group, but no significant differences were found between the DDR and DDNR groups. No significant correlation was found between the leptin and IL-6 concentrations.

Conclusion

Distinct changes in leptin and IL-6 concentrations in the SF occurred at the different stages of TMD, suggesting their potential implication in the pathogenesis of TMD.

https://ift.tt/2PRjkxD