Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy

Publication date: January 2019

Source: Oral Oncology, Volume 88

Author(s): Diane Evrard, Petr Szturz, Annemilaï Tijeras-Raballand, Lucile Astorgues-Xerri, Chloé Abitbol, Valérie Paradis, Eric Raymond, Sébastien Albert, Béatrix Barry, Sandrine Faivre

Abstract

The microenvironment of solid tumors has become a promising target for future therapies modulating immune cells. Patients with advanced head and neck cancer, which still portends a poor outcome, are particularly in need of innovative approaches. In oral squamous cell carcinoma, high density of tumor-associated macrophages (TAMs) appears consistently associated with poor prognosis, whereas data are currently limited for other head and neck sites. Several approaches to block TAMs have been investigated, including TAMs inactivation by means of the colony stimulating factor 1 (CSF-1)/CSF-1 receptor (CSF-1R) inhibitors or strategies to reprogram TAMs from M2 protumoral phenotype toward M1 antitumoral phenotype. This review focuses on both prognostic and therapeutic aspects related to TAMs in head and neck carcinomas.

Graphical abstract

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