Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 19 Νοεμβρίου 2018

Predictors of response to omalizumab and relapse in chronic spontaneous urticaria: a study of 470 patients

Abstract

Background

Chronic spontaneous urticaria (CSU) is defined as spontaneous occurrence of wheals and/or angioedema for ≥ 6 weeks. Omalizumab is a monoclonal anti‐IgE antibody effective in refractory CSU but its mechanism of action and markers predictive of response remain not completely defined.

Objectives

To correlate baseline levels of two proposed biomarkers, total IgE (bIgE) and D‐dimer (bD‐dimer), and clinical parameters to omalizumab response and to relapses after drug withdrawal.

Methods

In this retrospective Italian multicenter study, clinical data were collected in 470 CSU patients, and bIgE and bD‐dimer were measured in 340 and 342 patients, respectively. Disease activity was determined by Urticaria Activity Score 7 (UAS7) at week 1 and 12 after omalizumab starting. Relapses were evaluated during a 2‐month and 3‐month interval after a first and a second course of treatment, respectively.

Results

bIgE correlated to a good response to omalizumab since levels were significantly higher in responders than non‐responders (P = 0.0002). Conversely, bD‐dimer did not correlate to response. There was no correlation between both bIgE and D‐dimer and either first or second relapse. Disease duration was significantly longer in patients who experienced either first or second relapse (P < 0.0001 and P = 0.0105, respectively), whilst baseline UAS7 correlated only to first relapse (P = 0.0023).

Conclusions

Our study confirms bIgE as a reliable biomarker predicting response to omalizumab in CSU, while it does not support the usefulness of bD‐dimer unlike previous findings. CSU duration before omalizumab and baseline UAS7 may be clinical markers of relapse risk.

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