Podoplanin expression in oral leukoplakia─a prospective study

Publication date: Available online 13 December 2018

Source: Journal of Cranio-Maxillofacial Surgery

Author(s): K.J. Grochau, A.F. Safi, U. Drebber, A. Grandoch, J.E. Zöller, M. Kreppel

Summary

Purpose

The aim of this prospective work was to examine oral leukoplakia for their podoplanin expression to determine whether podoplanin expression is associated with the degree of dysplasia.

Materials and Methods

We took biopsy samples from 50 patients with oral leukoplakia in 2013. The preparations studied by immunohistochemistry were analyzed in correlation with the degree of dysplasia and other clinicopathological variables.

Results

The Chi-square test showed a significant correlation between podoplanin expression and the degree of dysplasia according to the World Health Organizations's squamous intraepithelial neoplasia (SIN) classification (p = 0.033). Also, a significant association between age grouping and podoplanin expression was found. We were able to show that the distribution is the same for both age groups in relation to the score of podoplanin expression (p = 0.003).

Conclusion

In a comparable retrospective work of our working group, it could be shown that podoplanin is a reliable predictive marker for the assessment of the risk of malignant transformation. The present work was able to substantiate the assumption that podoplanin not only plays an important role in the context of malignant degeneration but also exerts a major influence in advance.

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