Radical Surgery for Head and Neck Rhabdomyosarcoma Failed Primary Chemotherapy

Objective: The aim of the study was to explore an optimal surgery way for head and neck rhabdomyosarcoma (HNRMS) children who have failed primary chemotherapy. Methods: A total of 51 HNRMS children who have failed primary chemotherapy were retrospectively analyzed from April 2005 to May 2017. Surgery was performed in 2 ways, widely radical resection (22 patients) and conservative resection (29 patients). Multivariate analysis was performed to identify the various variables related to overall survival (OS). Results: The estimated 5-year OS was 53%. Embryonic RMS enjoyed a favorable outcome than those nonembryonic RMS (P = 0.03). Head and neck rhabdomyosarcoma children who received partial remission (PR) after primary chemotherapy enjoyed a better outcome than those only achieved stable disease (SD) (P = 0.006). A total of 22 children accepted widely radical resection, whereas 29 patients got conservative resection. Interestingly, the 2 groups did not have a statistical significance (P = 0.86). However, the latter group children have conserved more important organs, such as eyeball, facial nerves, and enough mandible or maxilla bones, and have enjoyed a better life quality. Conclusion: Primary chemotherapy is most important for HNRMS children, which influences the prognosis of HNRMS widely. Conservative resection is an optimal surgery way for HNRMS, bringing a better life quality for these children. Address correspondence and reprint requests to Guo Wei, PhD, 639 Zhi Zao Ju Road, Shanghai 200011, PR China; E-mail: guoweicn@yahoo.com; Ren Guoxin, E-mail: renguoxincn@hotmail.com Received 19 June, 2018 Accepted 27 July, 2018 This work was supported by Shanghai Health and Family Planning Commission (No. 20154Y0057). WY and MX equally contributed to this work. The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

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