Severe uncontrolled eosinophilic asthma, which responded to benralizumab after failure to respond to mepolizumab

We present the case of eosinophilic asthma of a 55-year-old female, who was initially diagnosed bronchial asthma by the author in February 2008. The diagnosis was confirmed using the Global Initiative for Asthma guidelines.1 She showed forced expiratory volume in 1 second (FEV1) was 63.9 % of the predicted value with an increase of 12.9 % in FEV1 after 180 μg salbutamol inhaler. She had no history of smoking. She met the American Thoracic Society criteria for a diagnosis of refractory asthma.2 She had non-allergic asthma, diagnosed with serum total IgE level 94 IU/mL and negative results of serum specific IgE for common inhaled allergens including mold, and Dermatophagoides farinae and pteronyssinus.

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