The Reliability of MAML2 Gene Rearrangement in Discriminating Between Histologically Similar Glandular Odontogenic Cysts and Intraosseous Mucoepidermoid Carcinomas

Publication date: Available online 14 December 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Rekha Reddy, Mohammed N. Islam, Donald M. Cohen, Indraneel Bhattacharyya, Sarah G. Fitzpatrick, Seema Ganatra

Abstract

Objective

MAML2 expression is proven in the majority of mucoepidermoid carcinomas (MEC) arising in salivary glands. MEC can also occur intraosseously (IMEC). Glandular odontogenic cyst (GOC) is an odontogenic cyst with histologic overlap with IMEC. This study will determine the reliability of MAML2 in distinguishing cases of IMEC from GOC.

Study Design

An IRB-approved retrospective search of IMEC, GOC, and IMEC with prior history of GOC was performed within the archives of the University of Florida and University of Alberta Oral Pathology Biopsy Services. Nine cases from five patients were selected. Break apart fluorescent in situ hybridization analysis was performed on seven cases for the presence of MAML2 rearrangement.

Results

Four cases had negative MAML2 gene rearrangement while three cases had positive MAML2 gene rearrangement.

Conclusion

Although it can be concluded that the three cases with positive translocation for MAML2 are IMEC, the same conclusion could not be drawn for the four cases with negative translocation. Whether the cases that were negative for the translocation are GOCs with MEC-like islands or MAML2 negative IMEC could not be ascertained. Therefore, MAML2 rearrangement is not always reliable in differentiating IMECs and GOCs with overlapping histology.

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