Deep parotid lymph node metastasis is associated with recurrence in high-grade mucoepidermoid carcinoma of the parotid gland

Publication date: Available online 30 January 2019

Source: Journal of Oral and Maxillofacial Surgery

Author(s): Xue Shang, Qigen Fang, Fei Liu, Junfu Wu, Ruihua Luo, Jinxing Qi

Abstract

Purpose

Our goal was to assess the association between intraparotid lymph node (IPN) metastasis and prognosis in high-grade mucoepidermoid carcinoma (MEC) of the parotid gland.

Patients and Methods

Patients with surgically treated primary high-grade MEC of the parotid gland were retrospectively enrolled. The association between IPN metastasis and clinical-pathologic variables was analyzed by using Chi-square tests, and the recurrence-free survival (RFS) rate was calculated by the Kaplan-Meier method; independent prognostic factors were evaluated by the Cox proportional hazards method.

Results

IPN metastasis was noted in 59 (48.4%) patients, including 19 cases in the deep lobe and 47 cases in the superficial lobe of the parotid gland. IPN metastasis was significantly related to tumor stage and node stage regardless of the location of the metastasis in deep or superficial lobes. Patients with both superficial and deep lymph node metastasis had a low 5-year RFS rate of 11%. Cox model analysis reported that the status of IPN metastasis was an independent risk factor for recurrence.

Conclusions

IPN metastasis significantly decreases the RFS rate, especially when there is lymph node metastasis in the deep lobe of the parotid gland.

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