Periodontal status and clinical outcomes in kidney transplant recipients: a systematic review

Abstract

Objective

The aim of this systematic review was to identify clinical outcomes following kidney transplantation associated with periodontal status.

Material and Methods

A systematic review was conducted and included cross‐sectional, case control or cohort studies published until August 2018 from PubMed/Medline, Scopus, Science Direct and CENTRAL. The research was carried out using the following descriptors: "kidney transplantation", "chronic renal failure", "periodontal diseases", "periodontitis", "chronic periodontitis", "gingival hyperplasia", and "gingivitis". The outcomes comprised the clinical transplantation variables. Two independent reviewers extracted the data and assessed the quality of the studies using Newcastle‐Ottawa scale.

Results

The electronic search revealed 1063 potentially relevant studies. We selected 114 articles for reading the full text. Therefore, six studies met the inclusion criteria; one case‐control, three cross‐sectional and two cohort. All studies showed low risk of bias. The findings suggest that the periodontal status may be associated with the largest left ventricular mass, greater carotid thickness, graft rejection, lower graft survival and a higher mortality rate within 60 months among kidney transplant recipients.

Conclusion

The findings of this systematic review indicate that there is an association between periodontal status and worsening of graft function and systemic health among kidney transplant recipients.

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