Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Παρασκευή 11 Ιανουαρίου 2019

Trichoscopic signs in systemic lupus erythematosus: a comparative study with 109 patients and 305 healthy controls

Abstract

Background

Hair and scalp involvement in systemic lupus erythematosus (SLE) can manifest as scarring alopecia, non‐scarring alopecia or scalp/hair shaft changes without apparent hair loss. While trichoscopic signs in chronic cutaneous lupus are well estabished, data on SLE patients with normal‐looking or non‐scarring scalp are limited.

Objectives

To investigate trichoscopic features of SLE patients without chronic cutaneous scalp lesions and compare the findings with normal controls, as well as determine which feature associates with systemic disease. Furthermore, we aim to explore different clinical presentations of the scalp in SLE patients and their association with disease activity.

Methods

Trichoscopic photographs were taken from patients and healthy controls and evaluated by one blinded hair specialist. For SLE patients, their clinical presentations and evaluations for cutaneous, extracutaneous involvement; and SLE Activity Index 2000 (SLEDAI‐2K) score were documented.

Results

109 SLE patients and 305 healthy controls were included. Hair shaft changes were significantly more common in SLE and associated with higher SLEDAI‐2K (P<0.05). The most common feature was prominent arborizing blood vessels (60.6% vs. 18.4%, P<0.001), followed by thick arborizing blood vessels (57.8% vs. 10.2%, P<0.001), black dots (47.7% vs. 2%, P<0.001), brown scattered pigmentation (5.5% vs. 0.7%, P=0.005) and blue grey speckled pigmentation (44% vs.0.3%, P<0.001). When hair loss is diffuse and severe, there were associations with haematologic (P=0.002) and renal involvement (P=0.027 for proteinuria>500 mg/day, P=0.004 for proteinuria>1g/day).

Conclusions

Trichoscopic examination is a valuable tool for SLE diagnosis and monitoring. Severe diffuse non‐scarring alopecia most likely indicates active disease.

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