Clinicians vs. epidemiologists: Patch testing with methyldibromo glutaronitrile as a controversial issue

Abstract

The preservative methyldibromo glutaronitrile (MDBGN) (CAS 35691‐65‐7) is known since long as an important contact allergen mainly used in cosmetics (Review: [1]). MDBGN was banned EU‐wide from being used in leave‐on products in 2005, for rinse‐off products in 2008, and further restricted for non‐cosmetic (technical) applications in 2010. However, positive reactions in patch testing (PT) continued to occur.

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