Small-molecule targeted antitumor drugs are considered to be a promising treatment that can improve the efficacy and reduce side effects. PI3K/Akt signaling pathway is constantly activated in various cancers. We recently synthesized a series of novel compounds of PI3K/Akt pathway inhibitors and found the most effective analog to be W934. In this study, we explored the in-vitro and in-vivo antitumor effects of W934 on A549 non-small-cell lung cancer cells and HCT116 colorectal cancer cells. In-vitro...
Mon Mar 25, 2019 02:00
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Zhe Hong, Gang Wu, Zhen-Dong Xiang, Cheng-Dang Xu, Sheng-Song Huang, Chao Li, Lei Shi, Deng-Long WuAbstractProstate cancer (PCa) is one of the leading causes of cancer-related death worldwide, and it is almost incurable once it has developed into castration-resistance prostate cancer (CRPC). However, the mechanisms underlying the oncogenesis of PCa and CRPC remain elusive. Lysine-specific histone demethylase...
Tue Mar 26, 2019 14:03
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Shanshan Hu, Rui Wang, Mei Zhang, Kangkang Liu, Juan Tao, Yu Tai, Weijie Zhou, Qingtong Wang, Wei WeiAbstractB-cell activating factor from the tumor necrosis factor family (BAFF) has revealed its critical role in B cell proliferation and survival, as well as the pathogenesis of T-cell mediated autoimmune disease. However, the effect and molecular mechanisms of BAFF on T cell physiological function have not...
Tue Mar 26, 2019 14:03
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Shakila Sabir, Muhammad Sajid Hamid Akash, Fareeha Fiayyaz, Uzma Saleem, Malik Hassan Mehmood, Kanwal RehmanAbstractEndocrine disrupting chemicals (EDCs) have widespread environmental distribution originated from both natural and anthropogenic sources. From the last few decades, their contamination has been raised dramatically owing to continuous discharge in sewage and untreated industrial effluents. They...
Tue Mar 26, 2019 14:03
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Zizhen Si, Xue Wang, Changhui Sun, Yuchun Kang, Jiakun Xu, Xidi Wang, Yang HuiAbstractAdipose-derived stem cells (ASCs) are a subset of mesenchymal stem cells (MSCs) that can be obtained easily from adipose tissues and possess many of the same regenerative properties as other MSCs. ASCs easily adhere to plastic culture flasks, expand in vitro, and have the capacity to differentiate into multiple cell lineages,...
Tue Mar 26, 2019 14:03
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Xiwei Ji, Yuan Lu, Huifang Tian, Xiangrui Meng, Minji Wei, William C. ChoAbstractChemoresistance is one of the major challenges for the breast cancer treatment. Owing to its heterogeneous nature, the chemoresistance mechanisms of breast cancer are complicated, and not been fully elucidated. The existing treatments fall short of offering adequate solution to drug resistance, so more effective approaches are...
Tue Mar 26, 2019 14:03
Opinion statement The symptom prevalence in patients with advanced cancer depends on the type of primary cancer, and the palliative treatment varies according to the nature of the primary cancer. Palliative treatment for unresectable skin cancer has not been fully discussed. Patients with unresectable skin cancer sometimes show the primary lesion in the skin and metastases to the lung, skin, liver, and bone. Pain, anorexia, and dyspnea commonly occur in such patients, and bleeding,...
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Publication date: Available online 25 March 2019Source: International ImmunopharmacologyAuthor(s): Ang Li, Yan Liu, Xiaosong Zhu, Xiao Sun, Xiuli Feng, Dawei Li, Jiangqiang Zhang, Meihua Zhu, Zhongxi Zhao
Tue Mar 26, 2019 16:34
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