Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Πέμπτη 28 Μαρτίου 2019

Sleep Disorders

Staying awake to stay alive: A circuit controlling starvation-induced waking.
Related ArticlesStaying awake to stay alive: A circuit controlling starvation-induced waking. PLoS Biol. 2019 Mar 27;17(3):e3000199 Authors: Melnattur K, Shaw P Abstract The balance of sleep and wake is plastic and changes to meet environmental demands. Mechanisms that allow an animal to suppress sleep and maintain waking in potentially adverse situations could serve adaptive functions in evolution. The fruit fly, Drosophila melanogaster, is well poised...
pubmed: sleep
Thu Mar 28, 2019 14:01
Carbon Dioxide Narcosis or Sleep Deprivation?
Related ArticlesCarbon Dioxide Narcosis or Sleep Deprivation? Ann Am Thorac Soc. 2019 Mar 27;: Authors: Aberegg SK, Carr J PMID: 30917005 [PubMed - as supplied by publisher]
pubmed: sleep
Thu Mar 28, 2019 14:01
Reply: Carbon Dioxide Narcosis or Sleep Deprivation?
Related ArticlesReply: Carbon Dioxide Narcosis or Sleep Deprivation? Ann Am Thorac Soc. 2019 Mar 27;: Authors: Lanks CW, Sue DY, Rossiter HB PMID: 30916987 [PubMed - as supplied by publisher]
pubmed: sleep
Thu Mar 28, 2019 14:01
Sleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk: Implications for Trial Design and Precision Sleep Medicine.
Related ArticlesSleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk: Implications for Trial Design and Precision Sleep Medicine. Am J Respir Crit Care Med. 2019 Mar 27;: Authors: Zinchuk A, Yaggi HK PMID: 30916985 [PubMed - as supplied by publisher]
pubmed: sleep
Thu Mar 28, 2019 14:01
Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus.
Related ArticlesNeuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus. J Neurosci Res. 2019 Mar 27;: Authors: Garcia-Rill E Abstract Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals,...
pubmed: sleep
Thu Mar 28, 2019 14:01
Current knowledge of medical complications in adults with achondroplasia: a scoping review.
Related ArticlesCurrent knowledge of medical complications in adults with achondroplasia: a scoping review. Clin Genet. 2019 Mar 27;: Authors: Fredwall SO, Maanum G, Johansen H, Snekkevik H, Savarirayan R, Lidal IB Abstract This article provides an overview of the current knowledge on medical complications, health characteristics, and psychosocial issues in adults with achondroplasia. We have used a scoping review methodology particularly recommended...
pubmed: sleep
Thu Mar 28, 2019 14:01
Relationship Between Sleep Quality and Mood: Ecological Momentary Assessment Study.
Related ArticlesRelationship Between Sleep Quality and Mood: Ecological Momentary Assessment Study. JMIR Ment Health. 2019 Mar 27;6(3):e12613 Authors: Triantafillou S, Saeb S, Lattie EG, Mohr DC, Kording KP Abstract BACKGROUND: Sleep disturbances play an important role in everyday affect and vice versa. However, the causal day-to-day interaction between sleep and mood has not been thoroughly explored, partly because of the lack of daily assessment data....
pubmed: sleep
Thu Mar 28, 2019 14:01
Examining Sleep Duration and Sleep Health Among Sexual Minority and Heterosexual Adults: Findings From NHANES (2005-2014).
Related ArticlesExamining Sleep Duration and Sleep Health Among Sexual Minority and Heterosexual Adults: Findings From NHANES (2005-2014). Behav Sleep Med. 2019 Mar 27;:1-13 Authors: Caceres BA, Hickey KT Abstract OBJECTIVES: This study proposed to examine sexual identity differences in sleep duration and sleep health (use of sleep medications or sedatives, trouble sleeping, and diagnosis of sleeping disorders) among American adults. METHODS:...
pubmed: sleep
Thu Mar 28, 2019 14:01
Gender-specific differences in parental health-related quality of life in childhood cancer.
Related ArticlesGender-specific differences in parental health-related quality of life in childhood cancer. Pediatr Blood Cancer. 2019 Mar 27;:e27728 Authors: Rensen N, Steur LM, Schepers SA, Merks JH, Moll AC, Kaspers GJ, Grootenhuis MA, van Litsenburg RR Abstract BACKGROUND: Parents of children with cancer are at risk for impaired health-related quality of life (HRQoL). Most prior research has focused on the HRQoL of mothers. The aim of this study...
pubmed: sleep
Thu Mar 28, 2019 14:01
Twin-based Heritability of Actimetry Traits.
Related ArticlesTwin-based Heritability of Actimetry Traits. Genes Brain Behav. 2019 Mar 27;:e12569 Authors: Gehrman PR, Ghorai A, Goodman M, McCluskey R, Barilla H, Almasy L, Roenneberg T, Bucan M Abstract There is a critical need for phenotypes with substantial heritability that can be used as endophenotypes in behavioral genetic studies. Activity monitoring, called actimetry, has potential as a means of assessing sleep and circadian rhythm traits...
pubmed: sleep
Thu Mar 28, 2019 14:01
Mindfulness-based stress reduction for women diagnosed with breast cancer.
Related ArticlesMindfulness-based stress reduction for women diagnosed with breast cancer. Cochrane Database Syst Rev. 2019 Mar 27;3:CD011518 Authors: Schell LK, Monsef I, Wöckel A, Skoetz N Abstract BACKGROUND: Breast cancer is the most common cancer in women. Diagnosis and treatment may drastically affect quality of life, causing symptoms such as sleep disorders, depression and anxiety. Mindfulness-based stress reduction (MBSR) is a programme that...
pubmed: sleep
Thu Mar 28, 2019 14:01
Health predictors and conditions associated to moderate and vigorous physical activity among adults and elderly from Southern Brazil.
Related ArticlesHealth predictors and conditions associated to moderate and vigorous physical activity among adults and elderly from Southern Brazil. Rev Bras Epidemiol. 2019 Mar 21;22:e190023 Authors: Dumith SC, Maciel FV, Borchardt JL, Alam VS, Silveira FC, Paulitsch RG Abstract INTRODUCTION: Regular physical activity (PA) generates several health benefits. This study aimed to analyze the predictors of moderate PA (MPA) and vigorous PA (VPA) separately,...
pubmed: sleep
Thu Mar 28, 2019 14:01
An exploratory study examining the associations between sunlight exposure, sleep behaviours and sleep outcomes during an Arctic summer.
Related ArticlesAn exploratory study examining the associations between sunlight exposure, sleep behaviours and sleep outcomes during an Arctic summer. Int J Circumpolar Health. 2019 Dec;78(1):1574698 Authors: Lubas MM, Maduro RS, Szklo-Coxe M Abstract Few evidence-based recommendations exist for maintaining healthy sleep during Arctic summers. Our study aimed to examine associations between sleep hygiene, sunlight exposure and sleep outcomes in workers...
pubmed: sleep
Thu Mar 28, 2019 14:01
Neurophysiological and Behavioral Effects of Anti-Orexinergic Treatments in a Mouse Model of Huntington's Disease.
Related ArticlesNeurophysiological and Behavioral Effects of Anti-Orexinergic Treatments in a Mouse Model of Huntington's Disease. Neurotherapeutics. 2019 Mar 26;: Authors: Cabanas M, Pistono C, Puygrenier L, Rakesh D, Jeantet Y, Garret M, Cho YH Abstract Huntington's disease (HD) is associated with sleep and circadian disturbances in addition to hallmark motor and cognitive impairments. Electrophysiological studies on HD mouse models have revealed an...
pubmed: sleep
Thu Mar 28, 2019 12:01
Guarana improves behavior and inflammatory alterations triggered by methylmercury exposure: an in vivo fruit fly and in vitro neural cells study.
Related ArticlesGuarana improves behavior and inflammatory alterations triggered by methylmercury exposure: an in vivo fruit fly and in vitro neural cells study. Environ Sci Pollut Res Int. 2019 Mar 27;: Authors: Algarve TD, Assmann CE, Cadoná FC, Machado AK, Manica-Cattani MF, Sato-Miyata Y, Asano T, Duarte MMMF, Ribeiro EE, Aigaki T, da Cruz IBM Abstract Methylmercury (MeHg) is a well-known environmental pollutant associated with neurological and developmental...
pubmed: sleep
Thu Mar 28, 2019 12:01
Thromboelastography Parameters Are Associated with Cirrhosis Severity.
Related ArticlesThromboelastography Parameters Are Associated with Cirrhosis Severity. Dig Dis Sci. 2019 Mar 26;: Authors: Kohli R, Shingina A, New S, Chaturvedi S, Benson A, Biggins SW, Bambha K Abstract BACKGROUND: Coagulopathy in cirrhosis represents complex coagulation derangements, and thromboelastography (TEG) measures these complex derangements. AIM: We sought to evaluate associations between TEG parameters and validated measures of cirrhosis...
pubmed: sleep
Thu Mar 28, 2019 12:01
Lung Cancer Screening and Epigenetics in African Americans: The Role of the Socioecological Framework.
Related ArticlesLung Cancer Screening and Epigenetics in African Americans: The Role of the Socioecological Framework. Front Oncol. 2019;9:87 Authors: Watson KS, Hulbert A, Henderson V, Chukwudozie IB, Aponte-Soto L, Lerner L, Martinez E, Kim S, Winn RA Abstract Lung cancer is the leading cause of cancer morbidity and mortality in the U.S. and racial/ethnic minorities carry the greatest burden of lung cancer disparities with African Americans (AAs) impacted...
pubmed: sleep
Thu Mar 28, 2019 12:01
Anaphylactic reaction to ethylene oxide in a hemodialysis patient.
Related ArticlesAnaphylactic reaction to ethylene oxide in a hemodialysis patient. SAGE Open Med Case Rep. 2019;7:2050313X19838744 Authors: Akhavan BJ, Osborn UA, Mathew R Abstract We present the case of a patient who developed a severe systemic allergic reaction during initiation of hemodialysis. The reaction completely resolved by switching the dialysis filter sterilized by ethylene oxide to a steam sterilized filter. Ethylene oxide is used to sterilize...
pubmed: sleep
Thu Mar 28, 2019 12:01
Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea.
Related ArticlesComparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea. Tanaffos. 2018 Mar;17(3):155-162 Authors: Schoebel C, Ghaderi A, Amra B, Soltaninejad F, Penzel T, Fietze I Abstract Background: Nowadays, the most practical approaches used to treat sleep apnea, are Continuous Positive Airway Pressure (CPAP), Bi-level Positive Airway Pressure therapy (BPAP), supplemental O2, servoventilation and/or a combination of these...
pubmed: sleep
Thu Mar 28, 2019 12:01
Sleep Bruxism and Occurrence of Temporomandibular Disorders-Related Pain: A Polysomnographic Study.
Related ArticlesSleep Bruxism and Occurrence of Temporomandibular Disorders-Related Pain: A Polysomnographic Study. Front Neurol. 2019;10:168 Authors: Smardz J, Martynowicz H, Michalek-Zrabkowska M, Wojakowska A, Mazur G, Winocur E, Wieckiewicz M Abstract Introduction: The diagnosis of sleep bruxism is challenging due to the difficulties involved. Sleep bruxism can lead to clinical consequences, including pain in masticatory muscles, limitation of jaw...
pubmed: sleep
Thu Mar 28, 2019 12:01
Emotional Memory Moderates the Relationship Between Sigma Activity and Sleep-Related Improvement in Affect.
Related ArticlesEmotional Memory Moderates the Relationship Between Sigma Activity and Sleep-Related Improvement in Affect. Front Psychol. 2019;10:500 Authors: Jones BJ, Fitzroy AB, Spencer RMC Abstract Sleep is essential for regulating mood and affect, and it also consolidates emotional memories. The mechanisms underlying these effects may overlap. Here, we investigated whether the influence of sleep on affect may be moderated by emotional memory consolidation....
pubmed: sleep
Thu Mar 28, 2019 12:01
Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation.
Related ArticlesDevelopmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation. Front Psychiatry. 2019;10:118 Authors: Agorastos A, Pervanidou P, Chrousos GP, Baker DG Abstract Early life stressors display a high universal prevalence and constitute a major public health problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) could represent...
pubmed: sleep
Thu Mar 28, 2019 12:01
Parental Perspectives on Psychiatric Comorbidity in Preschoolers With Autism Spectrum Disorders Receiving Publicly Funded Mental Health Services.
Related ArticlesParental Perspectives on Psychiatric Comorbidity in Preschoolers With Autism Spectrum Disorders Receiving Publicly Funded Mental Health Services. Front Psychiatry. 2019;10:107 Authors: Muratori F, Turi M, Prosperi M, Narzisi A, Valeri G, Guerrera S, Santocchi E, Apicella F, Lattarulo C, Calderoni S, Vicari S Abstract An increased prevalence of psychiatric comorbidity (PC) in individuals with Autism Spectrum Disorders (ASD) is consistently...
pubmed: sleep
Thu Mar 28, 2019 12:01
Human Heart Rhythms Synchronize While Co-sleeping.
Related ArticlesHuman Heart Rhythms Synchronize While Co-sleeping. Front Physiol. 2019;10:190 Authors: Yoon H, Choi SH, Kim SK, Kwon HB, Oh SM, Choi JW, Lee YJ, Jeong DU, Park KS Abstract Human physiological systems have a major role in maintenance of internal stability. Previous studies have found that these systems are regulated by various types of interactions associated with physiological homeostasis. However, whether there is any interaction between...
pubmed: sleep
Thu Mar 28, 2019 12:01
Good News: Family Medicine Specialists Have More Opportunity to Diagnose Undiagnosed Sleep Apnea in Children.
Related ArticlesGood News: Family Medicine Specialists Have More Opportunity to Diagnose Undiagnosed Sleep Apnea in Children. Malays J Med Sci. 2018 Sep;25(5):160-161 Authors: Chidambaram R PMID: 30914873 [PubMed]
pubmed: sleep
Thu Mar 28, 2019 12:01
Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.
Related ArticlesOctacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism. Sci Rep. 2019 Mar 26;9(1):5169 Authors: Sharma R, Matsuzaka T, Kaushik MK, Sugasawa T, Ohno H, Wang Y, Motomura K, Shimura T, Okajima Y, Mizunoe Y, Ma Y, Saber ZM, Iwasaki H, Yatoh S, Suzuki H, Aita Y, Han SI, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Shimano H Abstract ...
pubmed: sleep
Thu Mar 28, 2019 12:01
Connectivity differences between consciousness and unconsciousness in non-rapid eye movement sleep: a TMS-EEG study.
Related ArticlesConnectivity differences between consciousness and unconsciousness in non-rapid eye movement sleep: a TMS-EEG study. Sci Rep. 2019 Mar 26;9(1):5175 Authors: Lee M, Baird B, Gosseries O, Nieminen JO, Boly M, Postle BR, Tononi G, Lee SW Abstract The neuronal connectivity patterns that differentiate consciousness from unconsciousness remain unclear. Previous studies have demonstrated that effective connectivity, as assessed by transcranial...
pubmed: sleep
Thu Mar 28, 2019 12:01
Earlier introduction of solid food is associated with improved sleep in infants.
Related ArticlesEarlier introduction of solid food is associated with improved sleep in infants. Arch Dis Child Educ Pract Ed. 2019 Mar 26;: Authors: Dalrymple RA PMID: 30914404 [PubMed - as supplied by publisher]
pubmed: sleep
Thu Mar 28, 2019 12:01
Distribution of methyl and isopropyl N-methylanthranilates and their metabolites in organs of rats treated with these two essential-oil constituents.
Related ArticlesDistribution of methyl and isopropyl N-methylanthranilates and their metabolites in organs of rats treated with these two essential-oil constituents. Food Chem Toxicol. 2019 Mar 23;: Authors: Miltojević AB, Stojanović NM, Randjelović PJ, Radulović NS Abstract Two volatile alkaloids, methyl (MMA) and isopropyl N-methylanthranilates (IMA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacological...
pubmed: sleep
Thu Mar 28, 2019 12:01
A systematic review of natural language processing and text mining of symptoms from electronic patient-authored text data.
Related ArticlesA systematic review of natural language processing and text mining of symptoms from electronic patient-authored text data. Int J Med Inform. 2019 May;125:37-46 Authors: Dreisbach C, Koleck TA, Bourne PE, Bakken S Abstract OBJECTIVE: In this systematic review, we aim to synthesize the literature on the use of natural language processing (NLP) and text mining as they apply to symptom extraction and processing in electronic patient-authored...
pubmed: sleep
Thu Mar 28, 2019 12:01
Factors Influencing Time to Diagnosis in Childhood Narcolepsy Type 1.
Related ArticlesFactors Influencing Time to Diagnosis in Childhood Narcolepsy Type 1. J Child Neurol. 2019 Mar 27;:883073819836548 Authors: Levy S, McArthur I, Crow B, Zuberi S Abstract OBJECTIVE:: To study the variables impacting on time from symptom onset to diagnosis in childhood narcolepsy, including presence of cataplexy, onset in infancy, administration of the H1N1 Pandemrix vaccine, and date of diagnosis following the H1N1 pandemic. DESIGN::...
pubmed: sleep
Thu Mar 28, 2019 12:01
Prebiotics Versus Low FODMAP Diet: An Interpretative Nightmare.
Related ArticlesPrebiotics Versus Low FODMAP Diet: An Interpretative Nightmare. Gastroenterology. 2019 03;156(4):1222 Authors: Varney J, Muir JG, Gibson PR PMID: 30543795 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
Symptom clusters and quality of life in breast cancer survivors after cancer treatment in a tertiary hospital in Korea.
Related ArticlesSymptom clusters and quality of life in breast cancer survivors after cancer treatment in a tertiary hospital in Korea. Eur J Cancer Care (Engl). 2018 Nov;27(6):e12919 Authors: Nho JH, Kim SR, Park MH, Kweon SS Abstract We investigated the symptom clusters and effects of symptom clusters on the quality of life of Korean breast cancer survivors. We recruited 241 breast cancer survivors and collected cross-sectional data on their symptoms....
pubmed: sleep
Thu Mar 28, 2019 12:01
Adapting summary scores for the PROMIS-29 v2.0 for use among older adults with multiple chronic conditions.
Related ArticlesAdapting summary scores for the PROMIS-29 v2.0 for use among older adults with multiple chronic conditions. Qual Life Res. 2019 Jan;28(1):199-210 Authors: Huang W, Rose AJ, Bayliss E, Baseman L, Butcher E, Garcia RE, Edelen MO Abstract PURPOSE: The patient-reported outcomes measurement information system 29-item profile (PROMIS-29 v2.0) is a widely used health-related quality of life (HRQoL) measure. Summary scores for physical and mental...
pubmed: sleep
Thu Mar 28, 2019 12:01
Carole L. Marcus, M.B.B.Ch. (1960 - 2017).
Related ArticlesCarole L. Marcus, M.B.B.Ch. (1960 - 2017). Behav Sleep Med. 2018 May-Jun;16(3):311-314 Authors: Xanthopoulos MS, Meltzer LJ PMID: 29517938 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine.
Related ArticlesBrain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine. Neurotoxicology. 2018 03;65:186-195 Authors: Machaalani R, Chen H Abstract Nicotine is the major neurotoxicant in cigarettes that affects many transmitter systems within the brain as well as other factors, including the growth factors. Brain derived neurotrophic factor (BDNF), is the most abundant growth factor in the brain and plays a critical...
pubmed: sleep
Thu Mar 28, 2019 12:01
New device for nonvolitional evaluation of quadriceps force in ventilated patients.
Related ArticlesNew device for nonvolitional evaluation of quadriceps force in ventilated patients. Muscle Nerve. 2018 05;57(5):784-791 Authors: Laghi F, Khan N, Schnell T, Aleksonis D, Hammond K, Shaikh H, Collins E, Jubran A, Tobin MJ Abstract INTRODUCTION: In mechanically ventilated patients, nonvolitional assessment of quadriceps weakness using femoral-nerve stimulation (twitch force) while the leg rests on a right-angle trapezoid or dangles from...
pubmed: sleep
Thu Mar 28, 2019 12:01
Do Obese Children Require Inpatient Monitoring After Adenotonsillectomy?
Related ArticlesDo Obese Children Require Inpatient Monitoring After Adenotonsillectomy? J Clin Sleep Med. 2017 06 15;13(6):775-776 Authors: Simakajornboon N PMID: 28502286 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
The Continued Search for Optimal Therapy in Patients With OSA and PTSD.
Related ArticlesThe Continued Search for Optimal Therapy in Patients With OSA and PTSD. J Clin Sleep Med. 2017 06 15;13(6):849 Authors: Williams SG, Collen JF, Lettieri CJ PMID: 28502285 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
Adverse Effects of Hypnotic Medications.
Related ArticlesAdverse Effects of Hypnotic Medications. J Clin Sleep Med. 2017 06 15;13(6):839 Authors: Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN PMID: 28454603 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
Advancing Treatment of Comorbid PTSD and OSA.
Related ArticlesAdvancing Treatment of Comorbid PTSD and OSA. J Clin Sleep Med. 2017 06 15;13(6):843-844 Authors: Goldstein LA, Colvonen PJ, Sarmiento KF PMID: 28454602 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
Hypnotics and the Risks of Dementia.
Related ArticlesHypnotics and the Risks of Dementia. J Clin Sleep Med. 2017 06 15;13(6):837 Authors: James W PMID: 28416045 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
Treatment of PTSD-Related OSA With CPAP is Associated With Only a Modest Improvement in PTSD: Possible Adjunctive Treatment With Mood Stabilizers.
Related ArticlesTreatment of PTSD-Related OSA With CPAP is Associated With Only a Modest Improvement in PTSD: Possible Adjunctive Treatment With Mood Stabilizers. J Clin Sleep Med. 2017 06 15;13(6):841 Authors: Gupta MA PMID: 28416044 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01
Commentary on Healthy School Start Times.
Related ArticlesCommentary on Healthy School Start Times. J Clin Sleep Med. 2017 05 15;13(5):761 Authors: Owens J, Troxel W, Wahlstrom K PMID: 28212695 [PubMed - indexed for MEDLINE]
pubmed: sleep
Thu Mar 28, 2019 12:01

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