PeerJ Computer SciencePredicting the effect of va...
PeerJ Computer SciencePredicting the effect of variants on splicing using Convolutional Neural NetworksMutations that cause an error in the splicing of a messenger RNA (mRNA) can lead to diseases in humans. Various computational models have been developed to recognize the sequence pattern of the splice sites. In recent studies, Convolutional Neural Network (CNN) architectures were shown to outperform other existing models in predicting the splice sites. However, an insufficient effort has been put...
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J Clin NeurosciAssociation of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study.Related Articles Association of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study. J Clin Neurosci. 2020 Jun 30;: Authors: Lee JK, Kim H, Hong JB, Sheen SH, Han IB, Sohn S Abstract BACKGROUND: The aim of this nationwide age- and sex matched longitudinal follow up study is to determine the...
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Latest Results for Investigational New DrugsA phase 1 study of the MDM2 antagonist RO6839921, a pegylated prodrug of idasanutlin, in patients with advanced solid tumorsSummary Purpose MDM2 is a negative regulator of the tumor suppressor p53. RO6839921 is an inactive pegylated prodrug of idasanutlin, an MDM2 antagonist, developed for intravenous administration. On cleavage by plasma esterases, the active principle (AP = idasanutlin) is released. This phase 1 study investigated the safety, pharmacokinetics,...
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Journal of vestibular research : equilibrium & orientationEffects of viewing distance on ocular vestibular evoked myogenic potentials (oVEMPs) for air- and bone-conducted stimuli at multiple sites.Effects of viewing distance on ocular vestibular evoked myogenic potentials (oVEMPs) for air- and bone-conducted stimuli at multiple sites. J Vestib Res. 2020 Jun 27;: Authors: Govender S, Colebatch JG Abstract BACKGROUND: The ocular vestibular evoked myogenic potential is otolith-dependent and has...
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pubmed: cell cycle arrestBufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation.Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation. Cell Oncol (Dordr). 2020 Jul 04;: Authors: Yu Z, Feng H, Zhuo Y, Li M, Zhu X, Huang L, Zhang X, Zhou Z, Zheng C, Jiang Y, Le F, Yu DY, Cheng...
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Latest Results for InflammationInterference with miR-210 Alleviated Renal Injury in Septic Rats by Inhibiting JAK-STAT PathwayAbstract Pediatric sepsis has become the leading cause of death in pediatric intensive care units (PICU). The regulation of target genes may be the key to the treatment of pediatric sepsis. The expression of miR-210 in rat serum was detected by RT-qPCR. The serum BUN, Scr, and CysC were detected by an automatic biochemical analyzer. The expression of inflammatory factors...
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Skull BaseNeck CT angiography examinations for pediatric oropharyngeal trauma: diagnostic yield and proposal of a new targeted technique.Related Articles Neck CT angiography examinations for pediatric oropharyngeal trauma: diagnostic yield and proposal of a new targeted technique. Pediatr Radiol. 2020 Jul 03;: Authors: Choi JJ, Burton CS, Danehy AR, Voss SD Abstract BACKGROUND: Neck computed tomography (CT) angiography is commonly ordered for pediatric patients with soft palate trauma to exclude...
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Larynx[A crosscorrelation analysis of fluctuations in heart rate and breathing when diagnosing the autonomic disorders in patients with hypotonic type of functional dysphonia].[A crosscorrelation analysis of fluctuations in heart rate and breathing when diagnosing the autonomic disorders in patients with hypotonic type of functional dysphonia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(5):60-66 Authors: Jurkov AY, Bahilin VM, Shustova TI, Alekseeva NS Abstract OBJECTIVE: To conduct a cross-correlation...
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Neurology IndiaTransient Global Amnesia - Risk Factors and Putative BackgroundMarta Waliszewska-Prosol, Marta Nowakowska-Kotas, Joanna Bladowska, Paulina Papier, Sławomir Budrewicz, Anna Pokryszko-DraganNeurology India 2020 68(3):624-629 Objectives: Transient global amnesia (TGA) is a temporary short-term reversible memory loss. Etiology of TGA remains unclear with various hypotheses. We analyzed clinical characteristics, neuroimaging, and electrophysiological findings as well as comorbidities and...
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bioRxiv Subject Collection: Evolutionary BiologyThe impact of purifying and background selection on the inference of population history: problems and prospects [NEW RESULTS]Current procedures for inferring population history are generally performed under the assumption of complete neutrality - that is, by neglecting both direct selection and the effects of selection on linked sites. We here examine how the presence of direct purifying and background selection may bias demographic inference by evaluating...
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Craniofacial Surgery - Current IssueTemporomandibular Joint Ankylosis in Pediatric Patients With Craniofacial Differences: Causes, Recurrence and Clinical OutcomesBackground: The authors present an institutional experience treating congenital and acquired temporomandibular joint (TMJ) ankylosis, detailing outcomes and potential risk factors of recurrence. Methods: Retrospective chart review identified patients with TMJ ankylosis (1976–2019). Clinical records, operative reports, and imaging studies...
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Craniofacial Surgery - Current IssueFirearm Projectile in the Preauricular Region: Why Remove It?No abstract availableCraniofacial Surgery - Current IssueWed Jul 01, 2020 03:00Timing of Ossification of the Anterior Skull Base in Syndromic SynostosisThe anterior skull base undergoes a progressive ossification after birth. This has implications on the epidural dissection of early trans-craniofacial osteotomy procedures such as monobloc advancements. Our purpose was to determine the rate of ossification...
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Craniofacial Surgery - Current IssueCorrelation of Intracranial Volume With Head Surface Volume in Patients With Multisutural CraniosynostosisIntracranial volume (ICV) is an important parameter for monitoring patients with multisutural craniosynostosis. Intracranial volume measurements are routinely derived from computed tomography (CT) head scans, which involves ionizing radiation. Estimation of ICV from head surface volumes could prove useful as 3D surface scanners could be used to indirectly...
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histochemStructural and chemical changes in glial cells in the rat neocortex induced by constant occlusion of the middle cerebral artery.Structural and chemical changes in glial cells in the rat neocortex induced by constant occlusion of the middle cerebral artery. Acta Histochem. 2020 Jul;122(5):151573 Authors: Kalinichenko SG, Korobtsov AV, Matveeva NY, Pushchin II Abstract Stroke-induced changes in neuroglia determine the basic conditions for the survival and damage of neurons in the ischemic...
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The Journal of Immunology current issueCutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity [CUTTING EDGE]Key Points TNF is required for mycobacteria-induced upregulation of MINCLE and DECTIN-2. Inhibition of TNF in vivo abrogates Th17 responses by a MINCLE-dependent adjuvant.The Journal of Immunology current issueMon Jul 06, 2020 23:00Persistent Zika Virus Clinical Susceptibility despite Reduced Viral Burden in Mice with Expanded...
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Anticancer Res. 2020 Jul;40(7):3685-3696. doi: 10.21873/anticanres.14357.Protection of Bortezomib-induced Neurotoxicity by AntioxidantsYosuke Iijima 1, Kenjiro Bandow 2, Shigeru Amano 3, Motohiko Sano 4, Shunsuke Hino 5, Takahiro Kaneko 5, Norio Horie 5, Hiroshi Sakagami 6Affiliations expandPMID: 32620607 DOI: 10.21873/anticanres.14357AbstractBackground/aim: Although chemotherapy agents, such as oxaliplatin, cisplatin, paclitaxel and bortezomib frequently cause severe peripheral neuropathy, very...
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JoVE: Journal of Visualized ExperimentsSupervised Machine Learning for Semi-Quantification of Extracellular DNA in GlomerulonephritisExtracellular DNA (ecDNA) released during cell death is proinflammatory and contributes to inflammation. Measurement of ecDNA at the site of injury can determine the efficacy of therapeutic treatment in the target organ. This protocol describes the use of a machine learning tool to automate measurement of ecDNA in kidney tissue.JoVE: Journal of Visualized ExperimentsThu...
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Hormon- und StoffwechselforschungCentral Diabetes Insipidus Caused by Arginine Vasopressin Gene Mutation: Report of a Novel Mutation and Review of LiteratureHorm Metab ResDOI: 10.1055/a-1175-1307Familial neurohypophyseal diabetes insipidus (FNDI) is an autosomal dominant hereditary disorder characterized by severe polydipsia and polyuria that usually presents in early childhood. In this study, we describe a new arginine vasopressin (AVP) gene mutation in an ethnic German family with FNDI and provide...
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G3: .Genes, Genomes, Genetics Mission - Online First ArticlesLoss of the Antimicrobial Peptide Mechnikowin Protects Against Traumatic Brain Injury Outcomes in Drosophila melanogasterNeuroinflammation is a major pathophysiological feature of traumatic brain injury (TBI). Early and persistent activation of innate immune response signaling pathways by primary injuries is associated with secondary cellular injuries that cause TBI outcomes to change over time. We used a Drosophila melanogaster model...
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GeroScienceIntegrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevityAbstract Adipose tissue plays an essential role in metabolic health. Ames dwarf mice are exceptionally long-lived and display metabolically beneficial phenotypes in their adipose tissue, providing an ideal model for studying the intersection between adipose tissue and longevity. To this end, we assessed the metabolome and lipidome of adipose tissue in Ames dwarf mice. We observed...
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bioRxiv Subject Collection: Evolutionary BiologyGenomic phylogeography of the White-crowned Manakin Pseudopipra pipra (Aves: Pipridae) illuminates a continental-scale radiation out of the Andes [NEW RESULTS]The complex landscape history of the Neotropics has generated opportunities for population isolation and subsequent diversification that place this region among the most species-rich in the world. Detailed phylogeographic studies are required to uncover the biogeographic histories of Neotropical...
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Resources, Vol. 9, Pages 84: Indigenous Labor and Land Resources: Guarani–Kaiowa's Politico–Economic and Ethnic ChallengesResources, Vol. 9, Pages 84: Indigenous Labor and Land Resources: Guarani–Kaiowa's Politico–Economic and Ethnic Challenges Resources doi: 10.3390/resources9070084 Authors: Antonio A. R. Ioris The article deals with the meaning and the management of land-based resources by indigenous peoples, which are analyzed through an assessment of the lived spaces of the Guarani–Kaiowa indigenous...
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Molecules, Vol. 25, Pages 3071: Molecular Structure Modulated Trap Distribution and Carrier Migration in Fluorinated Epoxy ResinMolecules, Vol. 25, Pages 3071: Molecular Structure Modulated Trap Distribution and Carrier Migration in Fluorinated Epoxy Resin Molecules doi: 10.3390/molecules25133071 Authors: Jin Li Yufan Wang Zhaoyu Ran Hang Yao Boxue Du Tatsuo Takada Surface charge accumulation on epoxy insulators is one of the most serious problems threatening the operation safety of the direct current...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 4776: Emerging Roles of Matricellular Proteins in Systemic SclerosisIJMS, Vol. 21, Pages 4776: Emerging Roles of Matricellular Proteins in Systemic Sclerosis International Journal of Molecular Sciences doi: 10.3390/ijms21134776 Authors: Daniel Feng Casimiro Gerarduzzi Systemic sclerosis is a rare chronic heterogenous disease that involves inflammation and vasculopathy, and converges in end-stage development of multisystem tissue fibrosis....
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 4867: The Associations between Outdoor Playtime, Screen-Viewing Time, and Environmental Factors in Chinese Young Children: The "Eat, Be Active and Sleep Well" StudyIJERPH, Vol. 17, Pages 4867: The Associations between Outdoor Playtime, Screen-Viewing Time, and Environmental Factors in Chinese Young Children: The "Eat, Be Active and Sleep Well" Study International Journal of Environmental Research and Public Health...
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Cancers, Vol. 12, Pages 1809: Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics AnalysisCancers, Vol. 12, Pages 1809: Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis Cancers doi: 10.3390/cancers12071809 Authors: Jia-Lian Yang Charles C.N. Wang Jia-Hua Cai Che-Yi Chou Yu-Chao Lin Chin-Chuan Hung Bladder cancer is a common malignancy with mechanisms of pathogenesis and progression. This...
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Antibiotics, Vol. 9, Pages 383: Application of Rank Annihilation Factor Analysis for Antibacterial Drugs Determination by Means of pH Gradual Change-UV Spectral DataAntibiotics, Vol. 9, Pages 383: Application of Rank Annihilation Factor Analysis for Antibacterial Drugs Determination by Means of pH Gradual Change-UV Spectral Data Antibiotics doi: 10.3390/antibiotics9070383 Authors: Esteki Dashtaki Heyden Simal-Gandara The main objective of this study was to develop a simple and efficient spectrophotometric...
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