Antibiotic resistance patterns of urinary tract pathogens in children from Central Romania

xlomafota13 shared this article with you from Inoreader Antibiotic resistance patterns of urinary tract pathogens in children from Central Romania Via Experimental and therapeutic medicine Exp Ther Med. 2021 Jul;22(1):748. doi: 10.3892/etm.2021.10180. Epub 2021 May 12. ABSTRACT One of the most frequent bacterial infections in children are urinary tract infections (UTIs). In recent years, an increasing incidence of UTIs caused by resistant bacterial strains has been observed, especially with extended-spectrum β-lactamase-producing Enterobacteriaceae that represent about 15% of UTIs. A retrospective study was performed comprising 331 pediatric cases with UTI. Our study aimed to detect the resistance of the uropathogens to common drugs used in UTI treatment. High resistance rates have been recorded for ampicillin, amoxicillin, trimethoprim/sulfamethoxazole (TMP/SMX), cefuroxime, and ciprofloxacin, among E. coli and Klebsiella. The multidrug-resistance (MDR) rate was detected in one-third of the uropathogens, among which more than half were isolated in patients with urinary tract abnormalities. Our study highl ighted that nitrofurantoin, ceftriaxone, amikacin and carbapenem may be used for the empirical treatment for febrile or complicated UTI in children. This is the first comprehensive study that evaluates antibiotic resistance in UTIs in children, and their association with urinary tract abnormalities in Romania. As a result of this research, the protocol for initial empiric treatment of infants with febrile or complicated UTI should be modified considering a detailed and ongoing monitoring of local sensitivity of uropathogens to antimicrobial agents. PMID:34055063 | PMC:PMC8138273 | DOI:10.3892/etm.2021.10180 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.