Role of primary tumor resection in patients with metastatic medullary thyroid cancer who have unresectable distant metastases

xlomafota13 shared this article with you from Inoreader Role of primary tumor resection in patients with metastatic medullary thyroid cancer who have unresectable distant metastases Via Head & Neck Abstract Background Whether patients with medullary thyroid carcinoma (MTC) who have unresectable synchronous distant metastases should undergo primary surgical resection (PTR) remains controversial. This study aimed to identify predictive factors associated with the survival of such patients. Methods We conducted a retrospective study of patients with MTC who were registered in the Surveillance, Epidemiology, and End Results registry. The overall and cancer-specific mortality rates were assessed using risk-adjusted Cox proportional hazards regression modeling and stratified propensity score matching. Results One hundred and eight matched patients were assessed. Patients in the PTR group had lower overall mortality than did those in the non-PTR group. The 1-, 3-, and 5-year overall and cancer-specific survival rates in the PTR group were significantly higher. Conclusions PTR appears to be the most appropriate intervention for patients with good performance status. Such patients are likely to benefit from surgery and to experience long-term stable disease. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.