Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma

alexandrossfakianakis shared this article with you from Inoreader Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma via JARO - Journal of the Association for Research in Otolaryngology via MedWorm.com AbstractNoise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of theStephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca2+... View on Web

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