Dynamic Prediction of Survival for Sinonasal Extranodal Natural Killer/T‐cell Lymphoma

alexandrossfakianakis shared this article with you from Inoreader Dynamic Prediction of Survival for Sinonasal Extranodal Natural Killer/T‐cell Lymphoma via The Laryngoscope This study developed a prognostic model and a web-based calculator specifically focussed on SN-ENKTL for otolaryngologists to use to facilitate timely treatment decisions for the disease. Background Extranodal natural killer/ T-cell lymphoma (ENKTL) is a rare malignant tumor. This study aimed to develop a predictive nomogram and a web-based survival rate calculator for dynamically predicting the survival of patients with sinonasal ENKTL (SN-ENKTL). Methods This study investigated patients (n = 134) with SN-ENKTL who had been initially treated in our hospital between Jan 2008 and Dec 2016. The patients were randomly divided into training and validation cohorts, in a 7:3 ratio. Independent prognostic factors were identified and integrated to build a predictive nomogram and a web-based calculator using the Cox-regression model. The nomogram was evaluated by consistency index and calibration curve. Results Age, lactate dehydrogenase, hemoglobin, Epstein–Barr virus DNA, and Ann Arbor stage were identified as independent risk factors. We constructed a predictive nomogram for survival and a web-based calculator (https://taiqinwang.shinyapps.io/DynNomapp/). Conclusion This study developed a prognostic model and a web-based calculator specifically focused on SN-ENKTL for otolaryngologists to use to facilitate timely treatment decisions for the disease. Level of Evidence 4 Laryngoscope, 2022 View on Web

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