Evaluating the role of tissue microRNA‐27b as a diagnostic marker for oral lichen planus and possible correlation with CD8

Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QpPsZt

Prediction of femtosecond laser ablation profile on human teeth

Abstract

To predict the laser ablation profile on dental hard tissue which will enable the user to optimize laser parameters so as to carry out the laser treatment with minimal tissue damage. The present study constructs a mathematical model to predict the ablation profile based on Gaussian beam distribution of laser intensity and correlates the model with experimentally obtained ablation parameters (effective Gaussian beam radius, ablation threshold fluence, and effective energy penetration depth). To obtain the ablation parameters, laser ablation experiments were carried out on dental hard tissues using Ti:Sapphire femtosecond laser (800 nm, 100 fs, 10 kHz). The method is further extended to predict the ablation rate and efficiency as well. The profile predicted from the mathematical model is compared with that of experimental results. It is found that the predicted ablation profile agrees well with the experimental profile for both enamel and dentin except a slight deviation at higher fluence for dentin. The calculated ablation rate is comparable to that of experimental results whereas for ablation efficiency appreciable deviation is observed in the case of dentin. The model succinctly predicts the ablation profile, ablation rate, and ablation efficiency which will enable to perform dental surgery at optimized laser processing conditions with high precision thus reducing the tissue damage appreciably. Once the details of lesion are known through proper diagnostic tools, the method enables the user to readily obtain optimum laser parameters. It can be used as a handy reference for dentists to perform damage-free surgery, ensuring quicker healing.

https://ift.tt/2zLlnOD

Digital behavior surveillance: monitoring dental caries and toothache interests of Google users from developing countries

Oral Diseases, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Ngtg26

Expression of ETS1 and LEF1 in Salivary Glands of Sjögren Syndrome Patients

Oral Diseases, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Ov75tH

Real‐world database examining the association between hydroxychloroquine and retinopathy in Taiwan

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xSJd9P

Microflora of normal maxillary sinuses: does it justify perioperative antibiotic treatment in sinus augmentation procedures

Abstract

Objectives

To investigate bacterial flora of normal maxillary sinuses in order to facilitate perioperative antibiotic management in sinus augmentation procedures.

Materials and methods

Specimens of maxillary sinus mucosa were harvested during planned orthognatic surgery in 18 patients with no evidence of rhinosinusitis. The samples were processed according to hospital routine for aerobic and anaerobic cultures.

Results

Ten maxillary sinuses were found sterile. Twenty-six (72%) maxillary mucosa specimens were culture-positive. Aerobes were recovered in 21 sinus samples (58%), predominantly as polymicrobial flora (18 cultures, 50% of all specimens), S. aureus in 2 sinuses of the same patient (6% of the samples), and Bacillus sp. in 1 sinus (3%). Anaerobes were isolated in 20 of 26 culture-positive specimens (56% of all sinus samples). They were recovered alone in 5 samples. Fifteen anaerobic cultures were polymicrobial (42% of all samples). Propionibacterium acnes was isolated from another 5 sinuses (14%) of 3 patients.

Conclusions

Our data support the policy of perioperative antibiotic prophylaxis in sinus augmentation procedures where Schneiderian membrane is perforated.

Clinical relevance

Evaluating the need of a perioperative antibiotic therapy in sinus augmentation procedures.

https://ift.tt/2NTHxqN

Evaluation of the genotoxic potential of different delivery methods of at-home bleaching gels: a single-blind, randomized clinical trial

Abstract

Objective

This single-blind, parallel, randomized clinical trial evaluated the genotoxic potential and effectiveness of 10% hydrogen peroxide (HP) in patients submitted to at-home bleaching.

Materials and methods

Sixty young volunteers with maxillary incisors equal to or darker than M1.5 were included in the study. Patients were submitted to bleaching for 14 days (30 min/day) with one of the three 10% HP treatments: the bleaching agent was delivered in a bleaching tray (White Class, FGM), whitening strips (White Strips, Oral-b), or in prefilled disposable trays (Opalescence Go, Ultradent). The color change was evaluated with the Vita Bleachedguide, and the micronucleus test of exfoliative oral mucosa was carried out, starting from a count of 1000 cells, at the baseline, immediately after and 30 days after the end of the treatment. The micronucleus data were evaluated with the Kruskal-Wallis and Wilcoxon tests and color change with the two-way ANOVA test and the Tukey test (α = 0.05).

Results

Significant whitening was observed for all groups after 14 days (p = 0.001) and was maintained after 30 days, with no difference between groups (p = 0.42). The micronucleus count did not indicate genotoxic potential in any of the groups studied (p = 0.32), irrespective of the time intervals (p = 0.62).

Conclusion

No genotoxic effects of 10% HP were observed in patients submitted to at-home bleaching systems (30 min/day for 14 days), even 30 days after the end of treatment.

Clinical significance

It is safe to use different systems to deliver 10% HP during at-home bleaching according to the manufacturers' recommendations, with no risk of genotoxic effects applied.

https://ift.tt/2y3c1Mc