! ORL via Alexandros G.Sfakianakis on Inoreader: Prevalence of esophageal neoplasia in short-segment versus long-segment Barrett’s esophagus

! ORL via Alexandros G.Sfakianakis on Inoreader

Prevalence of esophageal neoplasia in short-segment versus long-segment Barrett's esophagus Aug 24th 2015, 18:57 Abstract Background With heightened awareness of the increasing rate of esophageal adenocarcinoma and success of endotherapy for Barrett's neoplasia, our Barrett's center has seen a rise in referrals for evaluation and management of Barrett's esophagus. We sought to compare the prevalence of neoplasia in patients with short- (<3 cm) versus long-segment Barrett's esophagus (≥3 cm) referred to our Barrett's center. Methods We performed a retrospective analysis of endoscopic procedures and pathology reports in adult patients (age >18) referred to our Barrett's center over a 6-year period. Neoplasia was defined as low-grade dysplasia, high-grade dysplasia and superficial esophageal adenocarcinoma. Outcome measures included the prevalence of neoplasia in short- vs long-segment Barrett's esophagus. Results Four-hundred and eighty-five patients (74 % male) were identified; 51 % had short-segment and 49 % had long-segment Barrett's esophagus. The prevalence of neoplasia in short- vs long-segment Barrett's esophagus was 33.6 vs 59.1 % (low-grade dysplasia 8.0 vs 14.5 %, high-grade dysplasia 12.8 vs 24.7 %, esophageal adenocarcinoma 12.8 vs 20.0 %). Long-segment Barrett's esophagus was associated with 2.55-fold increase in odds of neoplasia relative to the short-segment group (OR 2.55, p < 0.001, CI 1.73–3.76). Conclusion Neoplasia was more prevalent in patients with long-segment Barrett's. Surprisingly, 23.4 % of patients with an "irregular Z line" harbored advanced neoplasia (high grade dysplasia or esophageal adenocarcinoma) in our biased referral population. This suggests that patients with an "irregular Z line" should be biopsied and, if intestinal metaplasia is detected, surveyed per established Barrett's esophagus guidelines.

You are receiving this email because you subscribed to this feed at blogtrottr.com. If you no longer wish to receive these emails, you can unsubscribe from this feed, or manage all your subscriptions