Place de la ventilation non invasive dans l’asthme aigu grave
Résumé La ventilation non invasive (VNI) a pris une place prépondérante en réanimation. Ses indications reconnues sont les exacerbations aiguës de bronchopneumopathie chronique obstructive et l’oedème aigu pulmonaire. Dans la dernière conférence commune SRLF, SPLF, et SFAR de 2006, aucune recommandation n’a été émise en ce qui concerne sa place dans la prise en charge… Continue reading Place de la ventilation non invasive dans l’asthme aigu grave
Vaccines: Keep your child’s shots on track
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Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness
Background: A rigorous research response is required to inform clinical and public health decision-making during an epi/pandemic. However, the ethical conduct of such research, which often involves critically ill patients, may be complicated by the diminished capacity to consent and an imperative to initiate trial therapies within short time frames. Alternative approaches to taking prospective… Continue reading Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness
Making smart investment decisions in clinical research
A recent trial in rheumatoid arthritis found an inexpensive, but infrequently used, combination of therapies is neither inferior nor less safe than an expensive biologic drug. If the trial had been conducted over 10 years ago, arguably 100’s of millions of dollars since spent on biologics could have been released to other, more effective treatments.… Continue reading Making smart investment decisions in clinical research
Seasonal allergies: Nip them in the bud
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Evaluación del Video Head Impulse Test (V-Hit) en el diagnóstico del neurinoma del acústico
Evaluación del Video Head Impulse Test (V-Hit) en el diagnóstico del neurinoma del acústico: Introducción: La gran mayoría de lesiones que comprometen el conducto auditivo interno corresponden a schwannomas vestibulares (90%). Dentro de las nuevas pruebas diagnósticas del sistema vestibular aparece la prueba de impulso cefálico y su registro con el video Head Impulse Test… Continue reading Evaluación del Video Head Impulse Test (V-Hit) en el diagnóstico del neurinoma del acústico
Mainly subarachnoid amyloid angiopathy with pseudotumoral course
Publication date: Available online 17 December 2015 Source:Clinical Neurology and Neurosurgery Author(s): Franco-Macías Emilio, Cerdá-Fuertes Nuria, Rivas-Infante Eloy, Roldán-Lora Florinda, Ávila-Polo Rainiero, Moniche-Alvarez Francisco from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mnn2Ae via IFTTT
Editorial board
Publication date: 15 January 2016 Source:Bioorganic & Medicinal Chemistry, Volume 24, Issue 2 from #Medicine via ola Kala on Inoreader http://ift.tt/1JGdBBe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Skd92N via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QTRzTw via IFTTT
En bloc spondylectomy combined with chest wall excision for spinal tumor via a modified posterior approach: a retrospective study on 21 patients
Publication date: January 2016 Source:Clinical Neurology and Neurosurgery, Volume 140 Author(s): Huadong Yang, Kedong Hou, Ning Lu, Songhua Xiao, Yan Wang ObjectiveThis study was to investigate the feasibility and efficacy of total en bloc spondylectomy (TES) combined with chest wall excision through a modified posterior approach in treating the patients with thoracic spinal tumor and… Continue reading En bloc spondylectomy combined with chest wall excision for spinal tumor via a modified posterior approach: a retrospective study on 21 patients
Benjamín Rosenblüt Gasman
Benjamín Rosenblüt Gasman Revista Otorrinolaringología y Cirugía de Cabeza y Cuello, órgano oficial de la Sociedad de Otorrinolaringología, Medicina y Cirugía de Cabeza y Cuello lamenta profundamente la partida de su ex director Dr. Benjamín Rosenblüt Gasman acontecida el 14 de septiembre del año en curso en la ciudad de Santiago. La triste noticia del… Continue reading Benjamín Rosenblüt Gasman
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ PREDICTORS OF WHOLE-BODY INSU... περισσότερα »
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ A Mathematical Model of the Pathogenesis, Prevention and Reversal of Type 2 Diabetes Joon Ha, et al. | Endocrinology | Dec 28, 2015 ------------------------------ --------... περισσότερα »
Facial asymmetries to the tears are rare. We report a pediatric original case that may fall within the framework of a Cayler syndrome.
Syndrome de Cayler : à propos d’un cas et revue de la littérature via Plastique Esthétique [image: Schéma d’anatomie. A. Depressor labii inferioris. B. Depressor anguli. ...] [image: Enfant atteint d’un syndrome de Cayler, de sexe masculin, âgé de trois ans et ...] [image: Enfant atteint d’un syndrome de Cayler, de sexe masculin, âgé de trois ans et ...] *Source:*Annales de Chirurgie Plastique Esthétique Author(s): J. Bellaiche, N. Correia, M.A. Bouche Pillon Persyn, S. Chiriac, F. Bodin, C. François Les asymétries faciales aux pleurs sont rares. Nous rapportons un cas pédiatrique orig...περισσότερα »
Skull Reshaping with Fat-Grafting Surgery
Skull Reshaping with Fat-Grafting Surgery by Burhan Özalp, Hüseyin Elbey, Mehmet Bozkurt via Plastic, Reconstructive & Aesthetic Surgery [image: A depression on the back of the head was presented by the patient for ...] [image: Thirteen months after surgery, the site of the fat graft has a natural ...] Autologous fat grafting has been increasingly performed by surgeons to restore fullness to the face and obtain a more youthful appearance.1 Although fat grafting is most frequently performed in the area of the face, it is used in many applications, such as improving congenital or acquir...περισσότερα »
Skull Reshaping
*Skull Reshaping *with Fat-Grafting Surgery B Özalp, H Elbey, M Bozkurt - Journal of Plastic, Reconstructive & …, 2015 - jprasurg.com Autologous fat grafting has been increasingly performed by surgeons to restore fullness to the face and obtain a more youthful appearance. 1 Although fat grafting is most frequently performed in the area of the face, it is used in many applications, such as improving *...* Παράθεση Αποθήκευση Περισσότερα Spring-assisted surgery. Could compression-springs play a role at the *skull reshaping *in severe posterior brachicephaly? N Ventura-Martinez, L Miraga...περισσότερα »
The surgical approach to the orbitozygomatic fracture: from a subciliary to a transconjunctival and to a novel extended transconjunctival approach without skin incisions
Evolution of via British Association of Plastic Surgeons Publication date: Available online 23 December 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Kunihiro Ishida BackgroundSurgical approach to the orbitozygomatic fracture evolved in the last 20 years to limit skin incisions and minimize external scars.MethodsThe approach to the orbitozygomatic fracture was evaluated by a retrospective chart review from 1992 to 2012 and advantages, disadvantages and complications were studied.ResultsSurgical approach to the orbitozygomatic fracture evolved from a s... περισσότερα »
Vaccines: Keep your child’s shots on track
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
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Place de la ventilation non invasive dans l’asthme aigu grave
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Résumé La ventilation non invasive (VNI) a pris une place prépondérante en réanimation. Ses indications reconnues sont les exacerbations aiguës de bronchopneumopathie chronique obstructive et l’oedème aigu pulmonaire. Dans la dernière conférence commune SRLF, SPLF, et SFAR de 2006, aucune recommandation n’a été émise en ce qui concerne sa place dans la prise en charge […]
Guillain Barré syndrome—Incidence and clinical course in Southern Rogaland, Norway
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Publication date: February 2016 Source:Clinical Neurology and Neurosurgery, Volume 141 Author(s): Elisabeth Farbu, Thomas Rudolph, Sigurbjørg Stefansdottir ObjectiveTo establish the incidence and clinical course of Guillain Barré syndrome (GBS) in a well-defined geographical area.Patients and methodsAll patients older than 16 years of age diagnosed with GBS were prospectively invited to join a follow-up study for […]
Seasonal allergies: Nip them in the bud
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
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Comparison of three different posterior fixation techniques in transforaminal lumbar interbody fusion for two-level lumbar degenerative diseases: At a mean follow up time of 46 months
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Publication date: February 2016 Source:Clinical Neurology and Neurosurgery, Volume 141 Author(s): Fubing Liu, Yuanwu Cao, Zhenzhou Feng, Xiaogang Zhou, Chun Jiang, Xilei Li, Zixian Chen, Zheng Li, Yun Liang, Xiaoxing Jiang, Jian Dong ObjectivesThis study sought to retrospectively compare three different posterior fixation techniques in transforaminal lumbar interbody fusion for two-level lumbar degenerative diseases.Patients and […]
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Nature chemical biology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5S2O via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Pu6tOK via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mnqGKj via IFTTT
Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Science translational medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5S2S via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Pu6thA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YKML7f via IFTTT
Comparison of the therapeutic effects of surgery combined with postoperative radiotherapy and standalone radiotherapy in treating spinal metastases of lung cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Publication date: February 2016 Source:Clinical Neurology and Neurosurgery, Volume 141 Author(s): Chao Zhang, Guowen Wang, Xiuxin Han, Zhiwu Ren, Jian Duo ObjectThere are few studies comparing the therapeutic efficacy between surgery combined with postoperative radiotherapy and standalone radiotherapy in treating spinal metastases of lung cancer. The aim of this clinical study was to compare the […]
Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Methods (San Diego, Calif.) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5S2W via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Pu6tOH via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YKMJfy via IFTTT
Resource utilization and costs for treatment of stroke patients in an acute stroke unit in Greece
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Publication date: Available online 24 December 2015 Source:Clinical Neurology and Neurosurgery Author(s): Persefoni Kritikou, Konstantinos Spengos, Nikolaos Zakopoulos, Yannis Tountas, John Yfantopoulos, Konstantinos Vemmos BackgroundStroke comprises the leading cause of death in Greece, and more than 40% of the overall lifetime cost for stroke care, represents the acute phase hospitalization. The aim of the present […]
TGF-β Isoforms in Wound Healing and Fibrosis
Transforming Growth Factors β (TGF-β) Isoforms in Wound Healing and Fibrosis: Abstract Scar formation, with persistent alteration of the normal tissue structure, is an undesirable and significant result of both wound healing and fibrosing disorders. There are few strategies to prevent or to treat scarring. The transforming growth factor beta (TGF-β) superfamily is an important mediator of tissue repair. Each TGF-β isoform may exert a different effect on wound healing, which may be context-dependent. In particular, TGF-β1 may mediate fibrosis in adults' wounds, while TGF-β3 may pro... περισσότερα »
Photography-based Skin Pigmentation Evaluation System
Development and Clinical Validation of a Novel Photography-based Skin Pigmentation Evaluation System: A Comparison with the Calculated Consensus of Dermatologists\: Abstract Objective Various cosmetics, medicines, and light, and laser treatments have been increasingly developed to improve pigmentary skin alterations such as melasma, actinic lentigo, and dyschromia. To determine the efficacy of these modalities in view of the changes in pigmentation, an objective and reliable device that has a comparable performance to that of physicians is required. We developed a novel photography...περισσότερα »
Sleep architecture and obstructive sleep apnea in obese children with and without metabolic syndrome: a case control study
Abstract Purpose Obesity and biochemical parameters of metabolic disorders are both closely related to obstructive sleep apnea (OSA). The aim of this study was to compare sleep architecture and OSA in obese children with and without metabolic syndrome. Methods Forty-two children with metabolic syndrome were selected as case group and 38 children without metabolic syndrome were matched for age, sex, and BMI as control group. The standardized Persian version of bedtime problems, excessive daytime sleepiness, awakenings during the night, regularity and duration of sleep, snoring (BE... περισσότερα »
Effects of Exergaming on Physical Activity in Overweight Individuals
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Abstract Background The majority of patients with overweight and type 2 diabetes show insufficient levels of daily physical activity (PA) and usually are among the least likely to engage in or adhere to any form of generic PA. Active video games (exergames) may be a solution to motivate these individuals to overcome their sedentary lifestyle. Objectives This systematic review was conducted to review the current evidence for the effectiveness of exergaming in overweight and type 2 diabetes mellitus and thus to evaluate the suitability of these games to be used as tools for exercis... περισσότερα »
Salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study
Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study: To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. AbstractObjective To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. Methods This is ... περισσότερα »
Mainly subarachnoid amyloid angiopathy with pseudotumoral course
[image: alertIcon.gif] Publication date: Available online 17 December 2015 *Source:*Clinical Neurology and Neurosurgery Author(s): Franco-Macías Emilio, Cerdá-Fuertes Nuria, Rivas-Infante Eloy, Roldán-Lora Florinda, Ávila-Polo Rainiero, Moniche-Alvarez Francisco from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1mnn2Ae via IFTTT
En bloc spondylectomy combined with chest wall excision for spinal tumor via a modified posterior approach: a retrospective study on 21 patients
[image: 1-s2.0-S0303846715X00126-cov150h.gif] Publication date: January 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 140 Author(s): Huadong Yang, Kedong Hou, Ning Lu, Songhua Xiao, Yan Wang ObjectiveThis study was to investigate the feasibility and efficacy of total en bloc spondylectomy (TES) combined with chest wall excision through a modified posterior approach in treating the patients with thoracic spinal tumor and posterior chest wall invasion.MethodsClinical data of 21 consecutive patients (7 males, 14 females; average age: 41.5, range: 20–69) who underwent the com... περισσότερα »
Long-term medication persistence in stroke patients treated with intravenous thrombolysis
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Maja Stefanovic Budimkic, Tatjana Pekmezovic, Ljiljana Beslac-Bumbasirevic, Marko Ercegovac, Ivana Berisavac, Predrag Stanarcevic, Visnja Padjen, Dejana R. Jovanovic ObjectiveThere are no data regarding long-term medication persistence in stroke survivors treated with intravenous thrombolysis (IVT), which is one of the most important determinants of treatment success. Our objective was to determine long-term medication persistence in stroke patients treated with...περισσότερα »
Development, validation and psychometric properties of a diagnostic/prognostic tool for breakthrough pain in mixed chronic-pain patients
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Boaz Gedaliahu Samolsky Dekel, Francesca Remondini, Alberto Gori, Alessio Vasarri, GianFranco Di Nino, Rita Maria Melotti Background/ObjectiveBreakthrough pain (BTP) shows variable prevalence in different clinical contexts of cancer and non-cancer patients. BTP diagnostic tools with demonstrated reliability, validation and prognostic capability are lacking. We report the development, psychometric and validation properties of a diagnostic/prognostic tool, the IQ-B...περισσότερα »
Guillain Barré syndrome—Incidence and clinical course in Southern Rogaland, Norway
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Elisabeth Farbu, Thomas Rudolph, Sigurbjørg Stefansdottir ObjectiveTo establish the incidence and clinical course of Guillain Barré syndrome (GBS) in a well-defined geographical area.Patients and methodsAll patients older than 16 years of age diagnosed with GBS were prospectively invited to join a follow-up study for two years.ResultsSeventeen patients were diagnosed with GBS; an incidence rate of 2.28/100 000 in 2006/2007, and 3.19/100 000 in 2007/2008 with an e... περισσότερα »
Comparison of three different posterior fixation techniques in transforaminal lumbar interbody fusion for two-level lumbar degenerative diseases: At a mean follow up time of 46 months
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Fubing Liu, Yuanwu Cao, Zhenzhou Feng, Xiaogang Zhou, Chun Jiang, Xilei Li, Zixian Chen, Zheng Li, Yun Liang, Xiaoxing Jiang, Jian Dong ObjectivesThis study sought to retrospectively compare three different posterior fixation techniques in transforaminal lumbar interbody fusion for two-level lumbar degenerative diseases.Patients and methodsThis was a retrospective single-center study including 84 patients who underwent TLIF instrumented with unilateral pedicle sc...περισσότερα »
Comparison of the therapeutic effects of surgery combined with postoperative radiotherapy and standalone radiotherapy in treating spinal metastases of lung cancer
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Chao Zhang, Guowen Wang, Xiuxin Han, Zhiwu Ren, Jian Duo ObjectThere are few studies comparing the therapeutic efficacy between surgery combined with postoperative radiotherapy and standalone radiotherapy in treating spinal metastases of lung cancer. The aim of this clinical study was to compare the clinical and functional efficacy, quality of life, and survival outcomes between surgery combined with postoperative radiotherapy and standalone radiotherapy in treat... περισσότερα »
Resource utilization and costs for treatment of stroke patients in an acute stroke unit in Greece
[image: S03038467.gif] Publication date: Available online 24 December 2015 *Source:*Clinical Neurology and Neurosurgery Author(s): Persefoni Kritikou, Konstantinos Spengos, Nikolaos Zakopoulos, Yannis Tountas, John Yfantopoulos, Konstantinos Vemmos BackgroundStroke comprises the leading cause of death in Greece, and more than 40% of the overall lifetime cost for stroke care, represents the acute phase hospitalization. The aim of the present study was to assess the resource utilization and estimate the costs for treatment of stroke patients in an Acute Stroke Unit (ASU).MethodsPatient... περισσότερα »
Gamma Knife Radiosurgery in the management of single and multiple brain metastases
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): D. Greto, S. Scoccianti, A. Compagnucci, C. Arilli, M. Casati, G. Francolini, S. Cecchini, M. Loi, I. Desideri, L. Bordi, P. Bono, P. Bonomo, I. Meattini, B. Detti, L. Livi ObjectivesTo evaluate the efficacy and safety of Gamma Knife Radiosurgery (GKRS) in the treatment of single and multiple brain metastases.Patients and methodsFrom October 2012 to June 2014 106 patients were treated with Radiosurgery (RS) for brain metastases at University of Florence. 77 out o...περισσότερα »
The diagnostic performance of ultrasonographic optic nerve sheath diameter and color Doppler indices of the ophthalmic arteries in detecting elevated intracranial pressure
[image: S03038467.gif] Publication date: Available online 15 December 2015 *Source:*Clinical Neurology and Neurosurgery Author(s): Mohammad Kazem Tarzamni, Babak Derakhshan, Ali Meshkini, Simin Mirakhor Samani, Daniel Fadaei Fouladi, Samira Mostafazadeh, Amir Rezakhah ObjectivesTo assess the diagnostic accuracy of ultrasonographic optic nerve sheath diameter (ONSD) measurement and color Doppler indices of the ophthalmic arteries in detecting an elevated intracranial pressure (ICP).Patients and methodsA total 60 patients with (cases, n=30) and without (controls, n=30) acute clinical a...περισσότερα »
Microparticle derived proteins as potential biomarkers for cerebral vasospasm post subarachnoid hemorrhage. A preliminary study
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Magdalena M. Przybycien-Szymanska, Yuchen Yang, William W. Ashley ObjectiveCerebral vasospasm (CV) and associated secondary brain injury are major contributors to death and disability after aneurysmal subarachnoid hemorrhage (aSAH). Microparticles (MP) are small vesicular micro-molecules released by red and white blood cells, platelets and endothelial cells that can change rapidly and specifically depending on the type of cellular insult. They may serve as useful... περισσότερα »
Correlating subcortical interhemispheric connectivity and cortical hemispheric dominance in brain tumor patients: A repetitive navigated transcranial magnetic stimulation study
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Nico Sollmann, Sebastian Ille, Lorena Tussis, Stefanie Maurer, Theresa Hauck, Chiara Negwer, Jan S. Bauer, Florian Ringel, Bernhard Meyer, Sandro M. Krieg ObjectiveThe present study aims to investigate the relationship between transcallosal interhemispheric connectivity (IC) and hemispheric language lateralization by using a novel approach including repetitive navigated transcranial magnetic stimulation (rTMS), hemispheric dominance ratio (HDR) calculation, and ...περισσότερα »
Paradoxical ischemia in bilateral Eagle syndrome: a case of false-localization from carotid compression
[image: S03038467.gif] Publication date: February 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 141 Author(s): Michael C. Dewan, Peter J. Morone, Scott L. Zuckerman, Nishit Mummareddy, Mayshan Ghiassi, Mahan Ghiassi from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1OvUmBD via IFTTT
Editorial Board
[image: alertIcon.gif] Publication date: January 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 140 from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1mnmTwr via IFTTT
Narrow bands of visible light upon skin disorders
The effects of narrow bands of visible light upon some skin disorders. A review: Abtract This review article focuses on clinical studies published in the fields of (i) photo-rejuvenation & anti-aging, (ii) oily or acne prone skin & related imperfections (iii) skin pigmentation & lightening, (iv) dandruff & other Malassezia-related skin disorders and (v) prevention and reversal of hair loss using non-thermal, non-ablative devices (principally light emitting diodes). It mainly focuses on clinical proof of performance and also on *in vitro* studies that support the clinical findings. ... περισσότερα »
External versus Internal Distraction Devices in Treatment of Obstructive Sleep Apnea in Craniofacial Anomalies
External versus Internal Distraction Devices in Treatment of Obstructive Sleep Apnea in Craniofacial Anomalies: Background: Obstructive sleep apnea is often associated with congenital craniofacial malformations due to hypoplastic mandible and decreased pharyngeal airway. In this study, we will compare external and internal distraction devices for mandibular lengthening in terms of effectiveness, results, patient comfort, and complications. Methods: Thirty-seven patients were treated by bilateral mandibular distraction osteogenesis for obstructive sleep apnea: 20 with external and 17...περισσότερα »
Oriental Nose Occidentalization and Perinasal Shaping by Augmentation of the Underdeveloped Anterior Nasal Spine
Oriental Nose Occidentalization and Perinasal Shaping by Augmentation of the Underdeveloped Anterior Nasal Spine: [image: image] Background: Augmentation of an underdeveloped anterior nasal spine (ANS) occidentalizes the Oriental nasal shape. The objective of this study was to investigate the effect of ANS augmentation using an injectable filler, assessing volumetric changes with 3-dimensional images and measuring 2-dimensional images. Methods: Forty Japanese patients were treated and evaluated before and after the augmentation. Local anesthetic was injected on the ANS for analgesi... περισσότερα »
Local release of pioglitazone (a peroxisome proliferator-activated receptor γ agonist) accelerates proliferation and remodeling phases of wound healing
Local release of pioglitazone (a peroxisome proliferator-activated receptor γ agonist) accelerates proliferation and remodeling phases of wound healing: Abstract Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily known for its anti-inflammatory and macrophage differentiation effects, as well as its ability to promote fat cell differentiation and reduce insulin resistance. Pioglitazone (Pio) is a PPARγ agonist used clinically as an anti-diabetic agent for improving insulin sensitivity in patients with diabetes. The objective of this ... περισσότερα »
Generation Y and the Integrated Plastic Surgery Residency Match
Generation Y and the Integrated Plastic Surgery Residency Match: A Cross-sectional Study of the 2011 Match Outcomes: [image: image]Background: Plastic surgery is the most competitive specialty in medicine. We sought to identify factors associated with the successful match of generation Y applicants into integrated plastic surgery residency. Methods: We utilized the most recent data from the Charting Outcomes in the Match published by the National Resident Matching Program in 2011. We had data on US senior or independent applicant status, Alpha Omega Alpha (AOA) status, attendance of ... περισσότερα »
Breast Implant–associated Anaplastic Large Cell Lymphoma
Breast Implant–associated Anaplastic Large Cell Lymphoma: Updated Results from a Structured Expert Consultation Process: [image: image]Background: Despite increased cases published on breast implant–associated anaplastic large cell lymphoma (BIA-ALCL), important clinical issues remain unanswered. We conducted a second structured expert consultation process to rate statements related to the diagnosis, management, and surveillance of this disease, based on their interpretation of published evidence. Methods: A multidisciplinary panel of 12 experts was selected based on nominations from... περισσότερα »
Co-targeting Androgen Receptor Splice Variants and mTOR signaling pathway for the Treatment of Castration-Resistant Prostate Cancer
Purpose: The PI3K/Akt/mTOR pathway is activated in most castration-resistant prostate cancer (CRPC). Transcriptionally active androgen receptor (AR) plays a role in the majority of CRPC. Therefore, co-targeting full-length (FL) AR and PI3K/Akt/mTOR signaling has been proposed as a possible more effective therapeutic approach for CRPC. However, truncated AR-splice variants (AR-Vs) that are constitutively active and dominant over FL-AR are associated with tumor progression and resistance mechanisms in CRPC. It is currently unknown how blocking the PI3K/Akt/mTOR pathway impacts prost... περισσότερα »
Defining the value of a comparative approach to cancer drug development
Comparative oncology as a tool in drug development is growing in recognition, but requires a deeper examination of the value of the approach and examples of the unmet needs in drug development that this approach could satisfy. This review seeks to demonstrate, through published literature and selected examples of comparative clinical trials, the types of drug development questions that are best answered by the comparative oncology approach. We maintain that consideration of the answers to these questions can begin to frame the value of this approach, thereby allowing a reasonable ... περισσότερα »
Laringoplastía de inyección con ácido hialurónico
Laringoplastía de inyección con ácido hialurónico, experiencia del Hospital Clínico de la Pontificia Universidad Católica de Chile: Introducción: El manejo inicial de la parálisis cordal unilateral incluye la observación en espera de la recuperación de la movilidad o la compensación, terapia fonoaudiológica o inyección de medialización temporal para llevar la cuerda a una posición más favorable para el cierre glótico. Este procedimiento puede realizarse en pabellón, o vía percutánea en paciente despierto. Existen varias opciones, siendo el ácido hialurónico (Restylane®) uno de los m... περισσότερα »
Identification of an immunogenic subset of metastatic uveal melanoma
Purpose: Uveal melanoma (UM) is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma (CM) with immunotherapies that augment naturally existing anti-tumor T cell responses, the role of these treatments for metastatic UM remains unclear. We sought to define the relative immunogenicity of these two melanoma variants and determine whether endogenous anti-tumor immune responses exist against UM. Experimental Design: We surgically procured liver metastases from UM (n=16) and CM (n...περισσότερα »
CD126 and targeted therapy with Tocilizumab in Chronic Lymphocytic Leukemia
Purpose: Experimental Design:The levels of membrane-bound CD126 expression were determined on freshly isolated CLL B-cells (n=58) using flow cytometry. These CLL cells were treated with Chlorambucil (CBL) or Fludarabine with or without anti-CD126 antibody Tocilizumab for 24 hours and IL-6-mediated STAT3 transcriptional activity and cell cycle alteration were evaluated. Results: CD126 surface expression was found in all cases and positively correlated with the levels of in vivo constitutive STAT3 activity. The levels of CD126 expression were significantly and positively correlated ... περισσότερα »
Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer
Purpose: Obesity, insulin resistance, and elevated levels of circulating proinflammatory mediators are associated with poorer prognosis in early-stage breast cancer. To investigate whether white adipose tissue (WAT) inflammation represents a potential unifying mechanism, we examined the relationship between breast WAT inflammation and the metabolic syndrome and its prognostic importance. Experimental Design: WAT inflammation was defined by the presence of dead/dying adipocytes surrounded by macrophages forming crown-like structures of the breast (CLS-B). Two independent groups wer...περισσότερα »
Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells
PURPOSE Thus far, dendritic cell (DC)-based immunotherapy of cancer was primarily based on in vitro-generated monocyte-derived DCs, which require extensive in vitro manipulation. Here, we report on a clinical study exploiting primary CD1c+ myeloid DCs, naturally circulating in the blood. EXPERIMENTAL DESIGN Fourteen stage IV melanoma patients, without previous systemic treatment for metastatic disease, received autologous CD1c+ myeloid DCs, activated by only brief (16h) ex vivo culture and loaded with tumor associated antigens of tyrosinase and gp100. RESULTS Our results show that... περισσότερα »
The ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model
The ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model: Abstract For proper wound healing, control of bacteria or bacterial infections is of major importance. While caring for a wound, dressing material plays a key role as bacteria can live in the bandage and keep re-infecting the wound. They do this by forming biofilms in the bandage, which slough off planktonic bacteria and overwhelm the host defense. It is thus necessary to develop a wound dressing that will inhibit bacterial growth. Th... περισσότερα »
Imaging strategy for response evaluation to chemoradiotherapy of the nodal disease in patients with head and neck squamous cell carcinoma
Imaging strategy for response evaluation to chemoradiotherapy of the nodal disease in patients with head and neck squamous cell carcinoma: Abstract BackgroundDefinitive chemoradiotherapy (CRT) is used to treat lymph node metastatic head and neck cancer patients. Regional control of the neck disease is important to improve the prognosis, and the accuracy of the method used to evaluate the metastatic lymph node(s) after CRT is crucial to the decision-making process for any following salvage surgery. MethodsPatients undergoing CRT were divided in two groups of patients of those sh...περισσότερα »
MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus
MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus: AbstractEsophageal cancer is a malignant disease with poor prognosis, increasing incidence, and ineffective treatment options. MicroRNAs are post-transcriptional regulators of gene expression involved in many biological processes including carcinogenesis. We determined miR-205 expression levels in tumor/non-tumor tissues of 45 esophageal cancer patients using qPCR and found that decreased level of miR-205 in tumor tissue correlates with poor overall survival in esophag...περισσότερα »
A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck
A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck: AbstractDNA double-strand breaks (DSBs) are one of the most serious forms of DNA damage to the cell, causing genomic instability and ultimately carcinogenesis. In this study, we hypothesized that single nucleotide polymorphisms (SNPs) at the micro RNA (miRNA)-binding sites of DSB repair genes may influence cancer risk by dysregulating target gene expression. To test our hypothesis, we firstly performed functional prediction for common SNPs i... περισσότερα »
Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma
Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma: Abstract Fibroblast growth factor receptor 3 (FGFR3) is a member of the fibroblast growth factor receptor tyrosine kinase family. It has been identified as a promising therapeutic target in multiple types of cancer. We have investigated FGFR3 protein expression and *FGFR3* gene copy-numbers in a single well-documented cohort of oral and oropharyngeal squamous cell carcinoma. Tissue microarray sets containing 452 formalin-fixed paraffin-embedded tissues were immunohistoche... περισσότερα »
Zolpidem use and motor vehicle collisions in older drivers
Zolpidem use and motor vehicle collisions in older drivers: • Prescribed sleep medicine use in the past 30 days is highest in women/older adults• Side effects that can affect driving safety are drowsiness/impaired coordination• Assess zolpidem use and motor vehicle collisions (MVC) over 5 years in old drivers• Zolpidem use was associated with higher MVC rates in women and adults ≥80 years old• Zolpidem-related MVCs may be avoided by initiating low doses, escalating as needed Highlights • Prescribed sleep medicine use in the past 30 days is highest in women/older adults • Side eff... περισσότερα »
Napping and associated factors
Napping and associated factors: a Japanese nationwide general population survey: • We analyzed the data of the Japanese general adult population survey to investigate napping habits.• The factors associated with high-frequency napping and long-duration napping were analyzed.• Some of the factors associated with high-frequency napping and long-duration napping differ.• The results should provide important data for future studies aimed at improvement of sleep habits. Highlights • We analyzed the data of the Japanese general adult population survey to investigate napping habits. • T... περισσότερα »
Liquid Thyroxine Ingested at Breakfast
A Double-Blind Placebo-Controlled Trial of Liquid Thyroxine Ingested at Breakfast: Results of the TICO Study: Thyroid , Vol. 0, No. 0. Author information Carlo Cappelli,1 Ilenia Pirola,1 Linda Daffini,1 Annamaria Formenti,1 Carmelo Iacobello,2 Alessandra Cristiano,1 Elena Gandossi,1 Enrico Agabiti Rosei,1 and Maurizio Castellano1 1Department of Medical and Surgical Sciences, Endocrine and Metabolic Unit, University of Brescia, Brescia, Italy. 2Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Address correspondence to: *Carlo Cappelli, MD* *...περισσότερα »
Maternal Iodine Nutrition and Thyroid Status on Cognitive Development
Effects of Maternal Iodine Nutrition and Thyroid Status on Cognitive Development in Offspring: A Pilot Study: Thyroid , Vol. 0, No. 0. Author information Mariacarla Moleti,1 Francesco Trimarchi,1 Gaetano Tortorella,2 Alice Candia Longo,2 Grazia Giorgianni,1 Giacomo Sturniolo,1 Angela Alibrandi,3 and Francesco Vermiglio1 1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. 2Department of Pediatric, Gynecological, and Biomedical Sciences, University of Messina, Messina, Italy. 3Department of Economic Sciences, University of Messina, Messina, Italy...περισσότερα »
Insulin-like growth factor-1 receptor for predicting early glottic carcinoma response to radiotherapy
The value of insulin-like growth factor-1 receptor for predicting early glottic carcinoma response to radiotherapy: The optimal management of laryngeal carcinoma requires tumor treatment and preservation of laryngeal functions, such as swallowing and voice quality. Radiotherapy (RT) can fulfill both criteria, although it remains important to identify predictors of radioresistance and reduce unnecessary irradiation. Insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor that plays a key role in cancer development, although its prognostic value after RT remains unk... περισσότερα »
Alpha and beta adrenergic receptors in the human nasal turbinate
Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate: Adrenergic receptors (ARs) include four general types (α1, α2, β1 and β2), which are found in different target tissues. α-AR agonists are commonly used for decongestant therapy of upper airway diseases. In order to clarify the roles of AR subtypes in the upper airways, we investigated the localization of these receptors by immunohistochemistry. AbstractObjective Adrenergic receptors (ARs) include four general types (α1, α2, β1 and β2), which are found in different target tissues.... περισσότερα »
Auris Nasus Larynx
*Article in Press* Topical application of timolol decreases the severity and frequency of epistaxis in patients who have previously undergone nasal dermoplasty for hereditary hemorrhagic telangiectasia - *Abstract* - *Full Text* - *Images* - *References* - *PDF (369 KB)* - *Download Images(.ppt)About Images & Usage* - *Email Article* - *Add to My Reading List* - *Export Citation* - *Create Citation Alert* - *Cited by in Scopus (0)* *Keiichi Ichimura[image: correspondence][image: email], Hisashi Kikuchi, Shoichiro Imayoshi, Mari Shimada Dias* *Auris ... περισσότερα »
Optimization of combinations of ginsenoside-Rg 1 , ginsenoside-Rb 1 , evodiamine and rutaecarpine for effective therapy of mouse migraine
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Abstract Wuzhuyu decoction (WZYD) is a classic traditional Chinese medicine (TCM) formula. It has been extensively used for treating migraine for thousands of years in TCM. Four potential active ingredients from WZYD, ginsenoside-Rg1 (Rg1), ginsenoside-Rb1 (Rb1), evodiamine (Ev) and rutaecarpine (Ru), were found to have positive correlations with pharmacodynamic indicators involving mouse migraine in our […]
Investigation of sedative and hypnotic effects of Amygdalus communis L. extract: behavioral assessments and EEG studies on rat
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Abstract Amygdalus communis L. (almond) has been traditionally used as a natural medicine in the treatment of various diseases. The present research studied the sedative and hypnotic effects of the aqueous fraction of seeds of almond in rats. In order to investigate these effects, a combination of behavioral methods (open field test and loss of […]
Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study
Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study: To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. AbstractObjective To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. Methods This is ... περισσότερα »
Delayed restoration of maximum speech discrimination scores in patients with idiopathic sudden sensorineural hearing loss
Delayed restoration of maximum speech discrimination scores in patients with idiopathic sudden sensorineural hearing loss: To assess possible delayed recovery of the maximum speech discrimination score (SDS) when the audiometric threshold ceases to change. AbstractObjective To assess possible delayed recovery of the maximum speech discrimination score (SDS) when the audiometric threshold ceases to change. Methods We retrospectively examined 20 patients with idiopathic sudden sensorineural hearing loss (ISSNHL) (gender: 9 males and 11 females, age: 24–71 years). The findings of pur...περισσότερα »
A quantitative study of intracranial hypotensive syndrome by magnetic resonance
[image: S03038467.gif] Publication date: Available online 21 December 2015 *Source:*Clinical Neurology and Neurosurgery Author(s): Weizhong Tian, Ji Zhang, Jinhua Chen, Ying Liu, Xiaoyun Chen, Ning Wang ObjectivesThe study aims to investigate the magnetic resonance imaging (MRI) findings of intracranial hypotension syndrome (IHS) and the change of quantitative indicators, so as to yield a deeper understanding of the disease.Patients and methodsThe clinical data and MRI findings of 26 cases of IHS which were confirmed by lumbar puncture were retrospectively analyzed. Two physicians e...περισσότερα »
Takotsubo cardiomyopathy in aneurysmal subarachnoid hemorrhage: Institutional experience and literature review.
[image: S03038467.gif] Publication date: Available online 17 December 2015 *Source:*Clinical Neurology and Neurosurgery Author(s): Murad Talahma, Ayham M. Alkhachroum, Mossaed Alyahya, Sunil Manjila, Wei Xiong ObjectivesTo review the current practice in the diagnosis, monitoring and management of TCM in SAH patients at our tertiary referral institution and the relevant literature, and to evaluate the effect of certain treatment modalities on the outcome of those patients.Patients and MethodsA retrospective institutional chart review of 800 patients with aneurysmal SAH from 2007-2014... περισσότερα »
Topical application of timolol decreases the severity and frequency of epistaxis
Topical application of timolol decreases the severity and frequency of epistaxis in patients who have previously undergone nasal dermoplasty for hereditary hemorrhagic telangiectasia: Hereditary hemorrhagic telangiectasia (HHT) is widely known to cause bleeding that is difficult to control because of the associated vascular wall fragility. Although nasal dermoplasty results in decreased severity and frequency of nasal bleeding in patients with HHT, it does not eradicate epistaxis because this procedure cannot cover the entire nasal cavity. Residual bleeding warrants additional effec... περισσότερα »
Multi-centre randomised controlled trials (RCTs) in surgery
Novel ways to explore surgical interventions in randomised controlled trials: applying case study methodology in the operating theatre: Background: Multi-centre randomised controlled trials (RCTs) in surgery are challenging. It is particularly difficult to establish standards of surgery and ensure that interventions are delivered as intended. This study developed and tested methods for identifying the key components of surgical interventions and standardising interventions within RCTs.Qualitative case studies of surgical interventions were undertaken within the internal pilot phase ... περισσότερα »
Chronic sinusitis is a condition that occurs in patients with cystic fibrosis and is associated with the expression of numerous genes that determine an alteration in the secretion of chloride channel CFTR and hyperplasia of submucosal glands sinus epithelium
Técnica EXIT en Chile: La rinosinusitis crónica es una patología que se presenta en pacientes con fibrosis quística y se asocia a la expresión de numerosos genes que determinan una alteración en la secreción de cloro del canal CFTR e hiperplasia de las glándulas submucosas del epitelio sinusal. En este artículo se efectúa una revisión acerca de las indicaciones y distintas alternativas de cirugía endoscópica nasal para la rinosinusitis crónica en pacientes con fibrosis quística. Se realizó una búsqueda de artículos en PubMed, la biblioteca de Cochrane y en SciELO con fecha de public...περισσότερα »
Manejo de la rinosinusitis crónica en pacientes con fibrosis quística
Manejo de la rinosinusitis crónica en pacientes con fibrosis quística: La rinosinusitis crónica es una patología que se presenta en pacientes con fibrosis quística y se asocia a la expresión de numerosos genes que determinan una alteración en la secreción de cloro del canal CFTR e hiperplasia de las glándulas submucosas del epitelio sinusal. En este artículo se efectúa una revisión acerca de las indicaciones y distintas alternativas de cirugía endoscópica nasal para la rinosinusitis crónica en pacientes con fibrosis quística. Se realizó una búsqueda de artículos en PubMed, la biblio... περισσότερα »
Complicaciones velofaríngeas de adenoamigdalectomía
Complicaciones velofaríngeas de adenoamigdalectomía: Las cirugías de adenoides y amígdalas están entre las operaciones pediátricas más frecuentemente realizadas. A pesar de ser procedimientos seguros, las complicaciones existen y deben ser conocidas y manejadas por el cirujano que las realiza. La mayoría de los casos corresponden a sangrados intra o posoperatorios, pero existen otras complicaciones que pueden manifestarse o perdurar semanas o meses después del procedimiento. Las complicaciones velofaríngeas son disfunciones del esfínter palatofaríngeo, que normalmente abre o cierra ... περισσότερα »
Complicaciones posamigdalectomía
Complicaciones posamigdalectomía: Revisión desde la evidencia: La amigdalectomia corresponde a uno de los procedimientos quirúrgicos realizados con mayor frecuencia en niños. Aun cuando es considerado un procedimiento seguro, no se encuentra exento de complicaciones tanto intraoperatorias como posoperatorias precoces y tardías. El objetivo de este trabajo es revisar las potenciales complicaciones descritas en pacientes sometidos a amigdalectomia y su manejo perioperatorio considerando la evidencia y recomendaciones publicadas a la fecha con el fin de mejorar la toma de decisiones cl... περισσότερα »
Neoplasia asociada a Trichinella spiralis
Neoplasia asociada a Trichinella spiralis: La patología del cuello y su abordaje quirúrgico es una práctica clínica habitual para el cirujano de cabeza y cuello. El planteamiento de la cirugía será en base al diagnóstico de sospecha, con las pruebas de imagen y citología por punción de la tumoración cervical. En algunos casos el diagnóstico definitivo solo nos lo dará el estudio anatomopatológico de la pieza quirúrgica. Se presenta el caso de una tumoración cervical, de tórpida y rápida evolución, en la cual el agente Trichinella spiralis, pudo tener un papel en la etiología del cua... περισσότερα »
Partial auricle amputation with preservation of the inferior pedicle
Reconstrucción en un tiempo del pabellón auricular en amputación parcial traumática con preservación del pedículo inferior: Revisión de la literatura y presentación de dos casos: La amputación parcial traumática del pabellón auricular con preservación del pedículo inferior corresponde a una patología infrecuente. Su reconstrucción incluye el uso de diversas técnicas quirúrgicas. Presentamos dos casos de reimplante inmediato, sin uso de microcirugía, con resultados favorables y sin necesidad de reintervenciones, junto a una revisión de la literatura. La revisión bibliográfica realiza... περισσότερα »
Hibernomas en cabeza y cuello
Hibernomas en cabeza y cuello: Reporte de un caso clínico y revisión de la literatura: En el siguiente artículo se presenta un caso clínico de un adolescente de 14 años que consulta por presentar un aumento de volumen supraclavicular derecho y cuyo diagnóstico final realizado mediante estudio histológico luego de exéresis de la masa, concluye ser un hibernoma. Considerando la infrecuencia con la que se presentan este tipo de tumores benignos de los tejidos blandos, presentamos una descripción, mediante revisión bibliográfica, de dicha patología. ------------------------------ In thi... περισσότερα »
Glioma nasal gigante
Glioma nasal gigante, reporte de un caso: A case report: Los gliomas nasales son restos de tejido neuroglial que se presentan como una masa craneofacial. Es poco frecuente y no tiene características malignas, pero local-mente es bastante agresivo. Se encuentra dentro del diagnóstico diferencial de masas congénitas de la línea media. Se presenta el caso de un recién nacido que presenta un pólipo nasal derecho y distrés respiratorio. La RNM revela una masa intranasal sin conexión intracraneal. Vía endoscópica se realiza exéresis de la masa sin complicaciones. Biopsia confirma diagnóst...περισσότερα »
Filler rhinoplasty is a procedure in which dermal fillers are used to alter the nasal profile without invasive surgery
Rinomodelación y uso de Metacrill® en la punta nasal: Revisión de la literatura y presentación de un caso: La rinomodelación es un procedimiento en el cual se utilizan materiales de relleno inyectables para modificar el perfil nasal. Han existido más de 150 rellenos dérmicos en el mercado global, pero ninguno logra reunir todas las características ideales. El polimetilmetacrilato (PMMA) ha sido utilizado en medicina por más de 50 años como relleno dérmico y ha sido aprobado por la FDA para su uso en corrección de pliegues nasolabiales. Tras la inyección de PMMA, las microesferas gen... περισσότερα »
Osteoma frontoetmoidal
Osteoma frontoetmoidal, otras aplicaciones del Draf III, a raíz de un caso clínico: Presentamos el caso de una mujer de 57 años, que consulta tras notar un aumento de volumen pétreo y de lento crecimiento en el reborde orbitario medial derecho, asociado a obstrucción nasal, anosmia y descarga posterior. La evaluación clínico radiológica evidenció un gran osteoma frontoetmoidal derecho con compromiso orbitario y de la lamela lateral de la lámina cribosa, y además, una rinosinusitis crónica con pólipos. Se realizó una resección endoscópica del tumor por medio de un Draf III y una ciru... περισσότερα »
Sinus mucoceles are benign cysts that may appear in any sinus, but only 1%-10% occur in the sphenoid sinus
Sospecha clínica y tratamiento quirúrgico de los mucoceles esfenoidales: Introducción: Los mucoceles son formaciones benignas de lento crecimiento que pueden aparecer en cualquier seno paranasal, representando el seno esfenoidal menos del 10%. Objetivo: Presentamos nuestra experiencia de mucoceles en el seno esfenoidal. Material y método: Se obtuvieron los datos a partir de nuestra base de datos que recoge prospectivamente los casos de tumores de cabeza y cuello. Entre enero 1989 y enero 2013 se registraron 58 mucoceles en 54 pacientes, de los cuales 4 (7%) eran de seno esfenoidal. ...περισσότερα »
Laringoplastía de inyección con ácido hialurónico
Laringoplastía de inyección con ácido hialurónico, experiencia del Hospital Clínico de la Pontificia Universidad Católica de Chile: Introducción: El manejo inicial de la parálisis cordal unilateral incluye la observación en espera de la recuperación de la movilidad o la compensación, terapia fonoaudiológica o inyección de medialización temporal para llevar la cuerda a una posición más favorable para el cierre glótico. Este procedimiento puede realizarse en pabellón, o vía percutánea en paciente despierto. Existen varias opciones, siendo el ácido hialurónico (Restylane®) uno de los m... περισσότερα »
Burnout syndrome is generated against a chronic work stress on individuals working with people
Presencia de síndrome de Burnout en una muestra de residentes y otorrinolaringólogos de Chile: Introducción: El síndrome de Burnout o desgaste profesional relacionado con el trabajo se genera frente a un estrés laboral crónico en individuos que trabajan con personas. Se caracteriza por un agotamiento emocional, despersonalización y baja realización personal. Objetivo: Evaluar el síndrome de Burnout en los médicos residentes y otorrinolaringólogos (ORL) del país y establecer una relación entre las características sociodemográficas. Material y método: Se realizó un estudio de corte tr... περισσότερα »
Dacriocistorrinostomía endoscópica
Dacriocistorrinostomía endoscópica: Experiencia de 4 años del Hospital Clínico de la Universidad de Chile: Introducción: La dacriocistorrinostomía abierta es el gold estándar para el tratamiento de la obstrucción nasolacrimal, patología manifestada como epífora crónica, dacriocistitis y conjuntivitis recurrente. Desde el desarrollo del abordaje endonasal, se ha considerado como una alternativa terapéutica eficaz con notorias ventajas respecto a la técnica abierta y que además ofrece la posibilidad de corregir otras alteraciones de la nariz y cavidades paranasales en el mismo tiempo ... περισσότερα »
Evaluación del Video Head Impulse Test (V-Hit) en el diagnóstico del neurinoma del acústico
Evaluación del Video Head Impulse Test (V-Hit) en el diagnóstico del neurinoma del acústico: Introducción: La gran mayoría de lesiones que comprometen el conducto auditivo interno corresponden a schwannomas vestibulares (90%). Dentro de las nuevas pruebas diagnósticas del sistema vestibular aparece la prueba de impulso cefálico y su registro con el video Head Impulse Test (v-HIT) que permite el estudio de todos los canales semicirculares. Objetivo: Comparar el v-HIT para canales semicirculares laterales con las pruebas calóricas clásicas registradas mediante videonistagmografía en e... περισσότερα »
Blocking HSP90 addiction inhibits tumor cell proliferation, metastasis development and synergistically acts with zoledronic acid to delay osteosarcoma progression.
Purpose:Despite recent improvements in therapeutic management of osteosarcoma, ongoing challenges in improving the response to chemotherapy warrants the development of new strategies to improve overall patient survival. Among them, HSP90 is a molecular chaperone involved in the maturation and stability of various oncogenic proteins leading to tumor cells survival and disease progression. We assessed the antitumor properties of a synthetic HSP90 inhibitor, PF4942847, alone or in combination with zoledronic acid in osteosarcoma. Experimental Design:The effects of PF4942847 were eval...περισσότερα »
Surgical Guidance in Prostate Cancer: "From Molecule to Man" Translations
Given the frequency of the disease and the difficulty of tumor resections, image-guided surgery technologies may aid the surgical management of prostate cancer patients. The "from molecule to man" translation of such approaches is, however, complex and depends on many different features, both from a technical and a practical perspective. from Cancer via ola Kala on Inoreader http://ift.tt/1QTn5B6 via IFTTT
Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma
Abstract Fibroblast growth factor receptor 3 (FGFR3) is a member of the fibroblast growth factor receptor tyrosine kinase family. It has been identified as a promising therapeutic target in multiple types of cancer. We have investigated FGFR3 protein expression and *FGFR3* gene copy-numbers in a single well-documented cohort of oral and oropharyngeal squamous cell carcinoma. Tissue microarray sets containing 452 formalin-fixed paraffin-embedded tissues were immunohistochemically stained with an anti-FGFR3 antibody and hybridized with a *FGFR3* fluorescence in situ hybridization pr... περισσότερα »
Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Background: A rigorous research response is required to inform clinical and public health decision-making during an epi/pandemic. However, the ethical conduct of such research, which often involves critically ill patients, may be complicated by the diminished capacity to consent and an imperative to initiate trial therapies within short time frames. Alternative approaches to taking prospective informed consent may therefore be used. We aimed to rapidly review evidence on key stakeholder (patients, their proxy decision-makers, clinicians and regulators) views concerning the accepta... περισσότερα »
Making smart investment decisions in clinical research
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
A recent trial in rheumatoid arthritis found an inexpensive, but infrequently used, combination of therapies is neither inferior nor less safe than an expensive biologic drug. If the trial had been conducted over 10 years ago, arguably 100's of millions of dollars since spent on biologics could have been released to other, more effective treatments. Given the ever increasing number of trials proposed, this commentary uses the trial as an example to challenge payers and research funders to make smarter investments in clinical research to save potential future costs.Trial registrati... περισσότερα »
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Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Publication date: 15 January 2016 *Source:*Bioorganic & Medicinal Chemistry, Volume 24, Issue 2 from #Medicine via ola Kala on Inoreader http://ift.tt/1JGdBBe via IFTTT
Congenital nasolacrimal duct obstruction (DNL)
Manejo de obstrucción de vía lagrimal en niños mediante intubación con sonda Monoka®: Experiencia inicial en HCUCh: Introducción: La obstrucción congénita del ducto nasolacrimal (DNL) es motivo de consulta frecuente en menores de un año. Se encuentra en 6% de los recién nacidos, la mayoría de las veces secundario a la persistencia de una membrana mucosa en la porción distal del DNL (membrana de Hassner). Generalmente se presenta como epífora patológica, es decir, presente después del 3º mes de vida. Esta obstrucción puede evolucionar con resolución espontánea los primeros 12 meses de... περισσότερα »
Benjamín Rosenblüt Gasman
Benjamín Rosenblüt Gasman Revista Otorrinolaringología y Cirugía de Cabeza y Cuello, órgano oficial de la Sociedad de Otorrinolaringología, Medicina y Cirugía de Cabeza y Cuello lamenta profundamente la partida de su ex director Dr. Benjamín Rosenblüt Gasman acontecida el 14 de septiembre del año en curso en la ciudad de Santiago. La triste noticia del fallecimiento de quien fuera nuestro Jefe, Maestro y amigo durante muchos años nos conmovió profundamente. El Dr. Rosenblüt ingresó a la Escuela de Medicina de la Universidad de Chile y posteriormente trabajó como otorrino-laringólo...περισσότερα »
Congenital midline cervical cleft
Congenital midline cervical cleft: A retrospective case series of 8 children: Congenital midline cervical cleft is a rare developmental abnormality of the ventral neck of unclear etiology. It consists of a midline skin defect. This study reports a case series of 8 patients with congenital midline cervical cleft. AbstractObjectives Congenital midline cervical cleft is a rare developmental abnormality of the ventral neck of unclear etiology. It consists of a midline skin defect. This study reports a case series of 8 patients with congenital midline cervical cleft. Methods Retrospec... περισσότερα »
Caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage
The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage: The recently published article entitled “Effects of caffeic acid on cisplatin-induced hair cell damage in HEI-OC1 auditory cells” by Choi et al. [1] describes the administration of caffeic acid (CA, 3-(3,4-Dihydroxyphenyl)-2-propenoic acid) (Fig. 1) in a cell culture model of hair cell damage. The authors report that when CA was given to the cells in doses of 10 or 50μg/ml, it exhibited free radical scavenging activity and preventive for cisplatin-induced apoptosis. Moreover, ... περισσότερα »
L-Arginine Derivatives Are Associated with the Hyperthyroid State
L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population: Thyroid , Vol. 0, No. 0. Author information Till Ittermann,1,2,* Martin Bahls,2,3,* Dorothee Atzler,4,5,6 Nele Friedrich ,2,7 Edzard Schwedhelm,5,6Rainer H. Böger,5,6 Stephan B. Felix,2,3 Henry Völzke,1,2 and Marcus Dörr2,3 1Institute for Community Medicine, University Medicine Greifswald, Germany. 2Department of Internal Medicine B—Cardiology, Intensive Care, Pulmonary Medicine, and Infectious Diseases,University Medicine Greifswald, Germany. 3Division of Cardiovascular Medicine, Radcliffe D...περισσότερα »
Acute illness research
Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness: Background: A rigorous research response is required to inform clinical and public health decision-making during an epi/pandemic. However, the ethical conduct of such research, which often involves critically ill patients, may be complicated by the diminished capacity to consent and an imperative to initiate trial therapies within short time frames. Alternative approaches to taking prospective informed consent may therefore be us... περισσότερα »
Bipolar fractional radiofrequency in the treatment of acne scars
High versus moderate energy use of bipolar fractional radiofrequency in the treatment of acne scars: a split-face double-blinded randomized control trial pilot study: AbstractBipolar fractional radiofrequency (FRF) device was firstly FDA-approved for treating atrophic acne scar in 2008 through the process of dermal coagulation and minimal epidermal ablation. The average energy at 60 mJ/pin was widely used to treat atrophic acne scars. However, the higher energy was delivered, the deeper ablation and coagulation were found. At present, the new generation of a device with bipolar FRF... περισσότερα »
Speech Understanding After Cochlear Implantation
Cortical Activation Patterns Correlate With Speech Understanding After Cochlear Implantation.: Objectives: Cochlear implants are a standard therapy for deafness, yet the ability of implanted patients to understand speech varies widely. To better understand this variability in outcomes, the authors used functional near-infrared spectroscopy to image activity within regions of the auditory cortex and compare the results to behavioral measures of speech perception. Design: The authors studied 32 deaf adults hearing through cochlear implants and 35 normal-hearing controls. The authors us... περισσότερα »
Recognition of Disordered Speech
The Role of Somatosensory Information in Speech Perception: Imitation Improves Recognition of Disordered Speech: Purpose Perceptual learning paradigms involving written feedback appear to be a viable clinical tool to reduce the intelligibility burden of dysarthria. The underlying theoretical assumption is that pairing the degraded acoustics with the intended lexical targets facilitates a remapping of existing mental representations in the lexicon. This study investigated whether ties to mental representations can be strengthened by way of a somatosensory motor trace. Method Follo...περισσότερα »
Spoken and Written Sentence Recognition
Integration of Partial Information Within and Across Modalities: Contributions to Spoken and Written Sentence Recognition: Purpose This study evaluated the extent to which partial spoken or written information facilitates sentence recognition under degraded unimodal and multimodal conditions. Method Twenty young adults with typical hearing completed sentence recognition tasks in unimodal and multimodal conditions across 3 proportions of preservation. In the unimodal condition, performance was examined when only interrupted text or interrupted speech stimuli were available. In the ... περισσότερα »
Investigation of sedative and hypnotic effects of Amygdalus communis L. extract: behavioral assessments and EEG studies on rat
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Amygdalus communis L. (almond) has been traditionally used as a natural medicine in the treatment of various diseases. The present research studied the sedative and hypnotic effects of the aqueous fraction of seeds of almond in rats. In order to investigate these effects, a combination of behavioral methods (open field test and loss of […]
Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract A methanol extract from the rhizomes of Kaempferia parviflora Wall. ex Baker (Zingiberaceae) has shown inhibitory effects against melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells (IC50 = 9.6 μg/mL). Among 25 flavonoids and three acetophenones isolated previously (1–28), several constituents including 5-hydroxy-7,3′,4′-trimethoxyflavone (6, IC50 = 8.8 μM), 5,7,3′,4′-tetramethoxyflavone (7, 8.6 μM), 5,3′-dihydroxy-3,7,4′-trimethoxyflavone (12, […]
Migräne – wenn der Kopf zu platzen droht
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Attackenweise Kopfschmerzen Anfallsartiger Kopfschmerz, begleitet von Appetitlosigkeit, Übelkeit, Erbrechen – hier liegt der Verdacht auf Migräne nahe. Wie Sie Ihren Verdacht erhärten können und welche Möglichkeiten der Therapie es gibt, erfahren Sie hier. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mnjZIc via IFTTT
L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JGc7a4 via IFTTT
L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QTxL2t via IFTTT
Trends and socioeconomic differences in roll-your-own tobacco use: Findings from the ITC Europe Surveys
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Tobacco control from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YOsTL4 via IFTTT
Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Clinical cancer research : an official journal of the American Association for Cancer Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5Sjh via IFTTT
Quantifying anti-vascular effects of monoclonal antibodies to VEGF: insights from multi-modality cross species imaging in colorectal cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Clinical cancer research : an official journal of the American Association for Cancer Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YOsTuJ via IFTTT
Healthy lifestyle behaviors and all-cause mortality among adults in the United States
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Preventive medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YOsTuA via IFTTT
Trypanosome resistance to human innate immunity: targeting Achilles’ heel
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Trends in parasitology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YOsVCM via IFTTT
Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Methods (San Diego, Calif.) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5S2W via IFTTT
Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Science translational medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5S2S via IFTTT
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature chemical biology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5S2O via IFTTT
A meiotic mystery: How sister kinetochores avoid being pulled in opposite directions during the first division
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Bioessays from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YOsV5y via IFTTT
A model for extra-axonal diffusion spectra with frequency-dependent restriction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Magnetic Resonance in Medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5RMo via IFTTT
Time to eligibility for antiretroviral therapy in adults with CD4 cell count > 500 cells/μL in rural KwaZulu-Natal, South Africa
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
HIV Medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5OQO via IFTTT
Linkage disequilibrium network analysis (LDna) gives a global view of chromosomal inversions, local adaptation and geographic structure
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Molecular Ecology Resources from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5Qbd via IFTTT
Evaluation of lactate detection using selective multiple quantum coherence in phantoms and brain tumours
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nmr in Biomedicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YOsRmC via IFTTT
Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity-activation of metalloproteinases and γ-secretases
Abstract Stroke remains a leading cause of death and disability in the world with limited therapies available to restrict brain damage or improve functional recovery after cerebral ischaemia. A promising strategy currently under investigation is the promotion of brain-derived neurotrophic factor (BDNF)-signalling through tropomyosin-related kinase B (TrkB) receptors; a pathway essential for neuronal survival and function. However, TrkB and BDNF-signalling are impaired by excitotoxicity, a primary pathological process in stroke also associated with neurodegenerative diseases. Patho... περισσότερα »
Morphology and environment in some fossil Hominoids and Pedetids (Mammalia)
Abstract Linking the environment to functional anatomy is not an easy exercise, especially when dealing with fossils, which are often fragmentary and represent animals that are extinct. A holistic approach permits us to fill the gaps in reconstructing the evolutionary patterns in fossil groups. Identifying the environment where animals lived can help to interpret some anatomical structures and, *vice versa*, the functional morphological pattern can help to refine some fossil environments. Two examples focusing on locomotor behaviours in fossil mammals are considered in this paper: ... περισσότερα »
Functional MRI evidence for the decline of word retrieval and generation during normal aging
Abstract This fMRI study aimed to explore the effect of normal aging on word retrieval and generation. The question addressed is whether lexical production decline is determined by a direct mechanism, which concerns the language operations or is rather indirectly induced by a decline of executive functions. Indeed, the main hypothesis was that normal aging does not induce loss of lexical knowledge, but there is only a general slowdown in retrieval mechanisms involved in lexical processing, due to possible decline of the executive functions. We used three tasks (verbal fluency, obj...περισσότερα »
Role of diffusion-weighted magnetic resonance imaging in the evaluation of scalp dermatofibrosarcoma protuberans
Abstract Background Dermatofibrosarcoma protuberans (DFSP) is a rare tumor that grows with tentacle-like projections. In particular, on the scalp this could explain the frequent incomplete resections and the high rate of multiple local recurrences. Adequate pre- and postoperative imaging methods to visualize these prolongations are required to determine the extent of the tumor and to intercept recurrences in a short time base. Methods A retrospective study was performed on two cases of multiple recurrent scalp DFSP. The use of diffusion-weighted imaging (DWI) for pre- and postop... περισσότερα »
CANDLE SYNDROME: Orodfacial manifestations and dental implications
Abstract A South African girl with CANDLE Syndrome is reported with emphasis on the orodental features and dental management. Clinical manifestations included short stature, wasting of the soft tissue of the arms and legs, erythematous skin eruptions and a prominent abdomen due to hepatosplenomegaly. Generalized microdontia, confirmed by tooth measurement and osteopenia of her jaws,… Continue reading CANDLE SYNDROME: Orodfacial manifestations and dental implications
The Doylestown algorithm – a test to improve the performance of AFP in the detection of hepatocellular carcinoma.
Biomarkers for the early diagnosis of hepatocellular carcinoma (HCC) are needed to decrease mortality from this cancer. However, as new biomarkers have been slow to be brought to clinical practice we have developed a diagnostic algorithm that utilizes commonly used clinical measurements in those at risk of developing HCC. Briefly, as alpha fetoprotein (AFP) is… Continue reading The Doylestown algorithm – a test to improve the performance of AFP in the detection of hepatocellular carcinoma.
The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage
The recently published article entitled “Effects of caffeic acid on cisplatin-induced hair cell damage in HEI-OC1 auditory cells” by Choi et al. [1] describes the administration of caffeic acid (CA, 3-(3,4-Dihydroxyphenyl)-2-propenoic acid) (Fig. 1) in a cell culture model of hair cell damage. The authors report that when CA was given to the cells in… Continue reading The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
Nature chemical biology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5S2O via IFTTT
A meiotic mystery: How sister kinetochores avoid being pulled in opposite directions during the first division
Bioessays from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YOsV5y via IFTTT
Magnetic Resonance Imaging May Be a Valuable Radiation-Free Technique for Lung Pathologies in Patients with Primary Immunodeficiency
Abstract Purpose In some primary immunodeficiency (PID) patients, especially in the subgroup with common variable immunodeficiency (CVID), radiosensitivity is a concern and avoidance of repeated radiation exposure has been recommended. To investigate the use of lung Magnetic resonance imaging (MRI) instead of Computed Tomography (CT) for the diagnosis and follow-up of various lesions in the… Continue reading Magnetic Resonance Imaging May Be a Valuable Radiation-Free Technique for Lung Pathologies in Patients with Primary Immunodeficiency
Congenital midline cervical cleft: A retrospective case series of 8 children
Congenital midline cervical cleft is a rare developmental abnormality of the ventral neck of unclear etiology. It consists of a midline skin defect. This study reports a case series of 8 patients with congenital midline cervical cleft. from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OpPrvY via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via… Continue reading Congenital midline cervical cleft: A retrospective case series of 8 children
Angioedema Triggered by Medication Blocking the Renin/Angiotensin System: Retrospective Study Using the French National Pharmacovigilance Database
Abstract Introduction Bradykinin-mediated angioedema (AE) is a rare side effect of some medications, including angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB). In France, side-effects to treatments are reported to the national pharmacovigilance database. Methods The national MedDRA database was searched using the term “angioedema”. Patients were included if they met the clinical… Continue reading Angioedema Triggered by Medication Blocking the Renin/Angiotensin System: Retrospective Study Using the French National Pharmacovigilance Database
A model for extra-axonal diffusion spectra with frequency-dependent restriction
Magnetic Resonance in Medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sk5RMo via IFTTT
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