Detection of human papillomavirus infection in oral SCC
Detection of human papillomavirus infection in oral squamous cell carcinoma: a cohort study of Japanese patients: Objective Recent evidence suggests that human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a separate HNSCC subgroup with distinct epidemiology, histopathological characteristics, therapeutic response to chemotherapy and radiation, and clinical outcome. This study aimed to investigate the role of HPV infection in oral squamous cell carcinoma (OSCC) and the correlation between HPV infection, tumor suppressor protein p16 expression, and cl... περισσότερα »
Cartilage degradation in the temporomandibular joints : Cadherin-11 expression
Trend of Cadherin-11 expression and its impact on cartilage degradation in the temporomandibular joints of guinea pigs with spontaneous osteoarthritis: Background This study aims to investigate spatial and temporal changes in cadherin-11 (CAD-11) expression and their effects on cartilage degeneration in the temporomandibular joint (TMJ) of guinea pigs with spontaneous osteoarthritis (OA). Methods Dunkin-Hartley (DH) and Bristol strain 2 (BS2) guinea pigs at ages of 1, 3, 6, 9, and 12 months were categorized into two groups and analyzed. The bilateral TMJ condyles of DH and BS2 guin...περισσότερα »
Actinic cheilitis with different risks of malignant transformation
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation: Background Actinic cheilitis (AC) is a chronic inflammatory lesion that in some situations can turn into squamous cell carcinoma of the lip. The molecular mechanisms involved in this process are not yet completely understood. This study aimed to investigate the expression pattern of galectins in actinic cheilitis according to the histopathological grading. Methods Immunoexpression of galectin-1, galectin-3, galectin-7, and galectin-9 was semiquantitatively analyzed in 65 cases of a... περισσότερα »
Salivary cribriform basal cell tumors and adenoid cystic carcinoma : MYB expression and gene abnormalities
Differences in MYB expression and gene abnormalities further confirm that salivary cribriform basal cell tumors and adenoid cystic carcinoma are two distinct tumor entities: Background In practices, some cases of salivary basal cell tumors that consist mainly of cribriform growth pattern are difficult to differentiate from adenoid cystic carcinoma (AdCC). Identification of reliable molecular biomarkers for the differential diagnosis between them is required. Methods Twenty-two cases of cribriform salivary basal cell tumors (at least 10% cribriform pattern present in each tumor) comp... περισσότερα »
Enamel organ proteins as targets for antibodies in celiac disease
Enamel organ proteins as targets for antibodies in celiac disease: implications for oral health: Enamel defects in permanent and deciduous teeth may be oral manifestations of celiac disease. Sometimes they are the only sign that points to this underdiagnosed autoimmune pathology. However, the etiology of these specific enamel defects remains unknown. Based on previously reported cross-reactivity of antibodies to gliadin with the enamel proteins, amelogenin and ameloblastin, we analyzed (using immunohistochemistry) the ability of anti-gliadin IgG, produced during untreated disease, ... περισσότερα »
Narrow Band Imaging: Clinical Applications in Oral and Oropharyngeal Cancer
Narrow Band Imaging: Clinical Applications in Oral and Oropharyngeal Cancer: Abstract Narrow Band Imaging (NBI; Olympus Medical Systems Corporation, Tokyo, Japan) is an endoscopic optical imaging enhancement technology that improves the contrast of the mucosal surface texture and mucosal and submucosal vasculature. Utilising the principle that different wavelengths of light will penetrate at different depths, the technology filters white light to emit two 30-nm narrow bands of blue and green light simultaneously. The blue light centred at 415 nm corresponds to the main peak absorp...περισσότερα »
IRF6 and 8q24 region in non-syndromic oral clefts
Study of IRF6 and 8q24 region in non-syndromic oral clefts in the Brazilian population: Abstract Objective Investigating the association between non-syndromic oral cleft and variants in *IRF6* (rs2235371 and rs642961) and 8q24 region (rs987525) according to the ancestry contribution of the Brazilian population. Subjects and Methods Subjects with oral cleft (CL, CLP or CP) and their parents were selected from different geographical regions of Brazil. Polymorphisms were genotyped using a TaqMan assay and genomic ancestry was estimated using a panel of 48 INDEL polymorphisms. Results A... περισσότερα »
Sleep architecture and obstructive sleep apnea in children
Sleep architecture and obstructive sleep apnea in obese children with and without metabolic syndrome: a case control study: Abstract PurposeObesity and biochemical parameters of metabolic disorders are both closely related to obstructive sleep apnea (OSA). The aim of this study was to compare sleep architecture and OSA in obese children with and without metabolic syndrome. MethodsForty-two children with metabolic syndrome were selected as case group and 38 children without metabolic syndrome were matched for age, sex, and BMI as control group. The standardized Persian version o...περισσότερα »
Detection of Connexion 26 GENE (GJB2) Mutations in Cases of Congenital Non Syndromic Deafness
Detection of Connexion 26 GENE (GJB2) Mutations in Cases of Congenital Non Syndromic Deafness: AbstractHearing loss is most common form of genetic hearing disorder. Non-syndromic sensory neural autosomal recessive deafness (NSRD) is the most common form of genetic hearing loss. Mutations in GJB2 gene, which encodes the connexin 26 protein, are major cause of NSRD. The aim of this study is directed towards the mutations caused along the connexin 26 gene using blood samples from nonsyndromic deaf children. The study was conducted on 36 congenitally hearing impaired children who visit... περισσότερα »
Intractable Posterior Epistaxis due to a Spontaneous Low-Flow Carotid-Cavernous Sinus Fistula
Intractable Posterior Epistaxis due to a Spontaneous Low-Flow Carotid-Cavernous Sinus Fistula: A Case Report and a Review of the Literature: We report a case of a 90-year-old patient with intractable posterior epistaxis presenting as the only symptom of a nontraumatic low-flow carotid-cavernous sinus fistula. Purpose of this case report is to introduce low-flow carotid-cavernous sinus fistula in the differential diagnosis of intractable posterior epistaxis. We provide a literature review for the sequence of actions for the confrontation of posterior epistaxis. We also emphasize the ... περισσότερα »
DPOAEs : Non-invasive detection and monitoring of experimental hydrocephalus
Non-invasive detection and monitoring of experimental hydrocephalus with distortion product otoacoustic emissions via Auris Nasus Larynx Publication date: Available online 29 December 2015 *Source:*Auris Nasus Larynx Author(s): Hande Ezerarslan, Güçlü Kaan Beriat, Raziye Handan Nurhat, Burak Kazancı, Ferda Topal Çelikkan, Bizden Sabuncuoğlu, Hakan Sabuncuoğlu ObjectiveWe aimed to find out the effects of short term and long term hydrocephalus and intracranial ventricular volume changes on cochlear functions by using distortion product otoacoustic emission (DPOAE) in experimental hydroce... περισσότερα »
CRS : Olfactory acuity and sinonasal radiological findings
Correlation between olfactory acuity and sinonasal radiological findings in adult patients with chronic rhinosinusitis via Auris Nasus Larynx Publication date: Available online 29 December 2015 *Source:*Auris Nasus Larynx Author(s): Takahiro Saito, Kenzo Tsuzuki, Yoriko Yukitatsu, Masafumi Sakagami ObjectiveThis study aimed to clarify the correlation between olfactory disorder severity and radiological findings in patients with chronic rhinosinusitis (CRS) in the preoperative stage.MethodsFrom 2007 to 2014, 272 adult patients (163 men, 109 women; age range 22–80 years) with olfactory ...περισσότερα »
Maximum speech discrimination scores in patients with idiopathic sudden sensorineural hearing loss
Delayed restoration of via Auris Nasus Larynx Publication date: Available online 29 December 2015 *Source:*Auris Nasus Larynx Author(s): Yoshihiro Noguchi, Masatoki Takahashi, Taku Ito, Taro Fujikawa, Yoshiyuki Kawashima, Ken Kitamura ObjectiveTo assess possible delayed recovery of the maximum speech discrimination score (SDS) when the audiometric threshold ceases to change.MethodsWe retrospectively examined 20 patients with idiopathic sudden sensorineural hearing loss (ISSNHL) (gender: 9 males and 11 females, age: 24–71 years). The findings of pure-tone average (PTA), maximum SDS, a... περισσότερα »
Temporal bone chondroblastoma totally invisible on MRI
Temporal bone chondroblastoma totally invisible on MRI via Auris Nasus Larynx Publication date: Available online 29 December 2015 *Source:*Auris Nasus Larynx Author(s): Harukazu Hiraumi, Yoshiki Arakawa, Norio Yamamoto, Tatsunori Sakamoto, Juichi Ito We report a case of temporal bone chondroblastoma that was totally invisible on MRI. The patient was a 64-year-old man who presented with several months history of vertigo. The CT scan with bone window setting showed destruction of the temporomandibular joint, the floor of the middle cranial fossa, and the superior semicircular canal. Calc...περισσότερα »
Cervical lymph node metastases from remote primary tumor sites
Cervical lymph node metastases from remote primary tumor sites: Abstract Although most malignant lymphadenopathy in the neck represent lymphomas or metastases from head and neck primary tumors, occasionally, metastatic disease from remote, usually infraclavicular, sites presents as cervical lymphadenopathy with or without an obvious primary tumor. In general, these tumors metastasize to supraclavicular lymph nodes, but occasionally may present at an isolated higher neck level. A search for the primary tumor includes information gained by histology, immunohistochemistry, and evaluat...περισσότερα »
Communicative participation and postlaryngectomy speech outcomes
The relationship between communicative participation and postlaryngectomy speech outcomes: Abstract Background The purpose of this study was to examine relationships between communicative participation and postlaryngectomy speech outcomes, including listener-rated speech intelligibility and acceptability, and patient-rated speech acceptability and voice handicap. Methods Thirty-six laryngectomized individuals completed the Communicative Participation Item Bank (CPIB) short form and the Voice Handicap Index-10 (VHI-10). They provided recordings from the Sentence Intelligibility Test ...περισσότερα »
Regional variation in head and neck cancer mortality
Regional variation in head and neck cancer mortality: Role of patient and hospital characteristics: Abstract Background The purpose of this study was to determine whether outcomes in head and neck cancer would vary based on geographic location of patients. Methods A dataset from the California Cancer Registry was linked to publicly available discharge abstracts. Patients were separated into geographic areas based on health service areas (HSAs). Multilevel logistic regression models were constructed to include geographic, patient, and hospital-level characteristics. Results There was...περισσότερα »
Evaluation of Polo-like kinase 1 as a potential therapeutic target in Merkel cell carcinoma
Evaluation of Polo-like kinase 1 as a potential therapeutic target in Merkel cell carcinoma: Abstract Background Merkel cell carcinoma (MCC) is a rare and aggressive malignancy of the skin. Treatment options for MCC include surgery, radiotherapy, and chemotherapy. The purpose of this study was to assess the expression of Polo-like kinase 1 (PLK1) in MCC and the role of the inhibitor, BI2536, as a potential therapeutic option in MCC. Methods PLK1 expression was assessed in tissue samples from 28 patients with MCC and 5 healthy skin samples via immunohistochemistry and furthermore in ...περισσότερα »
Effect of β-catenin silencing in overcoming radioresistance of head and neck cancer cells by antagonizing the effects of AMPK on Ku70/Ku80
Effect of β-catenin silencing in overcoming radioresistance of head and neck cancer cells by antagonizing the effects of AMPK on Ku70/Ku80: ABSTRACT Background We attempted to elucidate the mechanism of cell death after radiation by studying how β-catenin silencing controls the radiation sensitivity of radioresistant head and neck cancer cells. Methods The most radioresistant cancer cell line (AMC-HN-9) was selected for study. Targeted silencing of β-catenin was used on siRNAs. Sensitivity to radiation was examined using clonogenic and methylthiazol tetrazolium (MTT) assays. Results...περισσότερα »
Transoral robotic medial hypopharyngectomy: Surgical technique
Transoral robotic medial hypopharyngectomy: Surgical technique: Abstract Background Transoral robotic surgery (TORS) has been shown to be both feasible and oncologically sound for use in early T classification hypopharyngeal cancers. The purpose of this study was to present our surgical technique for performing a transoral robotic hypopharyngectomy. Methods A 48-year-old man with a T2, N2a, M0 squamous cell carcinoma of the hypopharynx underwent a transoral robotic hypopharyngectomy and a left select neck dissection of levels II to IV. Results The hypopharyngeal tumor was removed en ... περισσότερα »
Transoral robotic surgery for early glottic carcinoma involving anterior commissure
Transoral robotic surgery for early glottic carcinoma involving anterior commissure: Preliminary reports: Abstract Background Transoral robotic surgery (TORS) for early glottic cancer has been reported, but the issue of anterior commissure involvement has seldom been addressed. Therefore, the purpose of this study was to preliminarily report the treatment results of TORS in this disease entity. Methods Eight patients with T1 and T2 glottic carcinoma with anterior commissure involvement were selected to receive TORS. The clinical parameters, including rates of adjuvant radiotherapy (...περισσότερα »
Delayed low frequency hearing loss caused by cochlear implantation interventions
Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy via Hearing Research Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Luke Campbell, Stephen O’Leary Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, fo... περισσότερα »
Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:Auris Nasus Larynx Author(s): Takayuki Nakagawa, Michio Yamamoto, Kozo Kumakawa, Shin-ichi Usami, Naohito Hato, Keiji Tabuchi, Mariko Takahashi, Keizo Fujiwara, Akira Sasaki, Shizuo Komune, Norio Yamamoto, Harukazu Hiraumi, Tatsunori Sakamoto, Akira Shimizu, Juichi Ito ObjectiveTo determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing […]
Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:Auris Nasus Larynx Author(s): Hideaki Shirasaki, Etsuko Kanaizumi, Tetsuo Himi ObjectiveAdrenergic receptors (ARs) include four general types (α1, α2, β1 and β2), which are found in different target tissues. α-AR agonists are commonly used for decongestant therapy of upper airway diseases. In order to clarify the roles of […]
Combining phase images from array coils using a short echo time reference scan (COMPOSER)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Purpose To develop a simple method for combining phase images from multichannel coils that does not require a reference coil and does not entail phase unwrapping, fitting or iterative procedures. Theory and Methods At very short echo time, the phase measured with each coil of an array approximates to the phase offset to which the […]
The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Sumeyya Akyol, Haci Kemal Erdemli, Ferah Armutcu, Omer Akyol from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JGVwmE via IFTTT
Congenital midline cervical cleft: A retrospective case series of 8 children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Sophie Achard, Xavier Leroy, Pierre Fayoux ObjectivesCongenital midline cervical cleft is a rare developmental abnormality of the ventral neck of unclear etiology. It consists of a midline skin defect. This study reports a case series of 8 patients with congenital midline cervical […]
Adolescents with chronic pain and associated functional disability: A descriptive analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
The purpose of this research was to describe the biopsychosocial characteristics of adolescents with chronic pain and functional disability. Data were obtained from a registry of 100 adolescents (mean age = 15.84, SD = 2.72; 21 males) admitted to an interdisciplinary pain rehabilitation program. Clinician ratings were used to categorize coping and personality styles. The […]
Surgeons aims and pain assessment strategies when managing paediatric post-operative pain: A qualitative study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Children experience moderate to severe pain post-operatively. Nurses have been found to have a variety of aims in this context. Surgeons’ aims when managing post-operative pain have not been explored. This qualitative study set out to explore paediatric surgeons’ aims when managing post-operative pain in one paediatric hospital in Canada. Consultant surgeons (n = 8) […]
Its all about the six-pack: Boys bodies in contemporary Western culture
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
This is an article about boys and their construction of masculinities. It draws on 5 years of qualitative research data from the same group of boys from early childhood through to 10 years of age in an attempt to articulate the way in which boys come to view their bodies, and other male bodies, in […]
Suicide of a close family member through the eyes of a child: A narrative case study report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
A narrative case study approach was used to collect a storied account from Joseph about his recollections and experience of the completed suicide of a family member with whom he lived with at 13 years of age. Data are presented longitudinally to capture Joseph’s perceptions and recollections of events leading up to, surrounding and following […]
Be my guest! Challenges and practical solutions of undertaking interviews with children in the home setting
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
This article aims to share critical debate on undertaking interviews with children in the home setting and draws on the authors’ extensive research fieldwork. The article focuses on three key processes: planning entry to the child’s home, conducting the interviews and exiting the field. In planning entry, we include children’s engagement and issues of researcher […]
Anaplastic Large-Cell Lymphoma of the Left Ventricle Presenting With Arrhythmia and Cerebral Infarction due to Cardiogenic Embolism
[image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] from Cancer via ola Kala on Inoreader http://ift.tt/1YLEEaq via IFTTT
A Child With Dyserythropoietic Anemia and Megakaryocyte Dysplasia Due to a Novel 5′UTR GATA1s Splice Mutation
We describe a child with dyserythropoietic anemia, thrombocytosis, functional platelet defect, and megakaryocyte dysplasia. We show that (i) this constellation of hematopoietic abnormalities was due to a germline mutation within the 5′ untranslated region (5′UTR) of globin transcription factor 1 (*GATA1*); (ii) the mutation impaired a 5′UTR *GATA1* splicing site, with promoted production of the shortened GATA1 isoform lacking the N-terminus; and (iii) expression of the GATA1 N-terminus is restricted to erythroblasts and megakaryocytes in normal marrow, consistent with the patient... περισσότερα »
Gorham–Stout Disease of the Skull Base With Hearing Loss: Dramatic Recovery and Antiangiogenic Therapy
[image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] Gorham–Stout disease (GSD) is a rare disorder of unknown etiology. We present a 6-year-old male with GSD involving the skull base who presented with recurrent cerebrospinal fluid (CSF) rhinorrhea, severe hearing loss, and facial palsy secondary to cerebellar herniation into the internal auditory canal. After 2 months of treatment with pegylated interferon (IFN) α-2b (50 μg/week), his hearing recovered dramatically. Two years later, new bone formation appeared radiologically and IFN was switched to sirolimus. One year after the swit... περισσότερα »
Ewing Sarcoma of the Head and Neck
Management and Outcome of Ewing Sarcoma of the Head and Neck: [image: cover.gif?v=1&s=86de6547f0744d5a90482061] Background Ewing sarcoma (EWS) of the head and neck is rare. Multimodal treatment consists of chemotherapy and local treatment; however, local treatment for EWS of the head and neck is challenging. The first objective was to describe local treatment administered to the patients with localized EWS of the head and neck according to the EURO-E.W.I.N.G.99-trial, and to assess the impact on survival. The second objective was to systematically review the scientific literatur... περισσότερα »
Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children
Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia: Background Discontinuation of *E. coli* l-asparaginase in patients with acute lymphoblastic leukemia (ALL) is unavoidable upon severe allergic reaction. We sought to examine outcomes following *E. coli* l-asparaginase discontinuation due to severe allergic reactions. Procedure We evaluated the outcome of children enrolled in Taiwan Pediatric Oncology Group-2002-ALL protocol between 2002 and 2012, who had *E. coli* l-asparaginase discontinued due t... περισσότερα »
Intensity-Modulated Radiation Therapy With Dose Painting for Intracranial Germ Cell Tumors
Intensity-Modulated Radiation Therapy With Dose Painting: A Brain-Sparing Technique for Intracranial Germ Cell Tumors: [image: cover.gif?v=1&s=86de6547f0744d5a90482061] Background We sought to assess patterns of failure in pediatric patients with intracranial germ cell tumors (GCT) treated with intensity-modulated radiation therapy with dose painting (DP-IMRT). Procedure Between July 2007 and October 2013, 11 patients with localized GCT—five germinomas and six nongerminoma GCT (NGGCT)—received definitive treatment with DP-IMRT. Three representative patients were selected for repl... περισσότερα »
Seroepidemiology of Human Polyomaviruses
Seroepidemiology of Human Polyomaviruses in a US Population: Polyomaviruses (PyV) are potentially tumorigenic in humans. However, limited data exist on the population seroprevalence of PyVs and individual characteristics that relate to seropositivity. Using multiplex serology, we determined the seroprevalence of 10 human PyVs (BK, JC, KI, WU, MCV, HPyV6, HPyV7, TSV, HPyV9, and HPyV10) among controls from a population-based skin cancer case-control study (*n* = 460) conducted in New Hampshire between 1993 and 1995. On a subset of participants (*n* = 194), methylation at CpG dinucleo... περισσότερα »
Endoglin overexpression is associated with highly proliferative tumor endothelium
Cancers, Vol. 8, Pages 3: Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects: Endoglin overexpression is associated with highly proliferative tumor endothelium and also with some tumors, including melanoma. Its targeting has anti-tumor effectiveness, which can also be obtained by RNA interference. The aim of our study was to explore the anti-tumor effectiveness of endoglin silencing by electrotransfer of plasmid DNA encoding short hairpin RNA against endog... περισσότερα »
Invasive fungal diseases in patients with multiple myeloma
Epidemiology and treatment of invasive fungal diseases in patients with multiple myeloma: findings from a multicenter prospective study from China: AbstractThe aim of this study is to investigate the epidemiology, diagnosis, treatment and risk factors of multiple myeloma patients with invasive fungi disease (IFD) in China. We analyzed multiple myeloma (MM) patients receiving chemotherapy in a prospective multicenter study. Basic characteristics, the diagnosis, and treatment of IFD were recorded. A total of 395 MM patients were enrolled, who received a total of 443 chemotherapy cour... περισσότερα »
Cranial nerve palsies, radicular symptoms, signs of increased intracranial pressure such as headache, nausea and vomiting, and cognitive dysfunction
Therapy of leptomeningeal metastasis in solid tumors via ScienceDirect Publication: Cancer Treatment Reviews Publication date: Available online 24 December 2015 *Source:*Cancer Treatment Reviews Author(s): F. Mack, B.G. Baumert, N. Schäfer, E. Hattingen, B. Scheffler, U. Herrlinger, M. Glas Leptomeningeal metastasis (LM), i.e. the seeding of tumor cells to the cerebrospinal fluid (CSF) and the leptomeninges, is a devastating and mostly late-stage complication of various solid tumors. Clinical signs and symptoms may include cranial nerve palsies, radicular symptoms, signs of increased i...περισσότερα »
Pediatric dysembryoplastic neuroepithelial tumors (DNETs)
MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors: AbstractAmong noncoding RNAs, microRNAs (miRNAs) have been most extensively studied, and their biology has repeatedly been proven critical for central nervous system pathological conditions. The diagnostic value of several miRNAs was appraised in pediatric dysembryoplastic neuroepithelial tumors (DNETs) using miRNA microarrays and receiving operating characteristic curves analyses. Overall, five pediatric DNETs were studied. As controls, 17 samples were used: the FirstChoice Human Brain Reference RN... περισσότερα »
Risk factors for measles in children younger than age 8 months: A case-control study during an outbreak in Guangxi, China, 2013
Publication date: Available online 28 December 2015 *Source:*American Journal of Infection Control Author(s): Zhen-Zhu Tang, Yi-Hong Xie, Chuleeporn Jiraphongsa, Xuan-Hua Liu, Zhong-You Li, Virasakdi Chongsuvivatwong BackgroundFollowing a period (2009-2012) during which zero measles cases were reported, a measles outbreak occurred in 2013 in Bama County, Guangxi, China, that involved more than 100 children younger than age 8 months. We aimed to identify the pitfalls and risk factors while implementing the control measures.MethodsAn outbreak investigation and a case-control study was...περισσότερα »
Heritability of naevus pattern
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract The morphological universe of naevi comprises a broad variability of clinical and dermoscopic patterns that are linked to peculiar histological and biological traits. Thus, the resulting naevus morphology is strongly affected by genetic and environmental factors. Twin studies have been used to explore the contribution of the genetics of various phenotypes. This article is […]
PSTPIP1 Gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) Syndrome
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract Pyoderma gangrenosum (PG) acne and suppurative hidradenitis (SH) (PASH) syndrome is a recently described condition which belongs to the spectrum of autoinflammatory diseases (AIDs). 1 AIDs are a group of heterozygous disorders characterized by disregulation of the innate immune response. 2PSTPIP1 gene mutations affecting proteins of the inflammasome complex or proteins that regulate it′s […]
Primary amelanotic rhabdoid melanoma of the forehead
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract Pathologists in general and dermatopathologist in particular are very well aware that melanomas can virtually mimic any type of cancer due to its huge versatility to adopt many cytomorphological and architectural variants1. In 1992, rhabdoid variant of melanoma was first described by Bittesini et al.2, which is considered an extremely rare variant of malignant […]
The role of PSMB9 up-regulated by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and lupus erythematosus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Summary Background Dermatomyositis (DM) and systemic lupus erythematosus (SLE) have common skin features, including dermal mucin deposition and interferon signature, although their roles are unknown. Objective To identify common or specific molecular changes in DM and SLE skin. Methods Proteomic analysis was performed utilizing DM and normal subject (NS) skin. Glycosaminoglycans were analyzed by high-performance […]
The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Sumeyya Akyol, Haci Kemal Erdemli, Ferah Armutcu, Omer Akyol from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1JGVwmE via IFTTT
Congenital midline cervical cleft: A retrospective case series of 8 children
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Sophie Achard, Xavier Leroy, Pierre Fayoux ObjectivesCongenital midline cervical cleft is a rare developmental abnormality of the ventral neck of unclear etiology. It consists of a midline skin defect. This study reports a case series of 8 patients with congenital midline cervical […]
Adaptation and Validation of the Voice-Related Quality of Life Measure Into Polish
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 28 December 2015 Source:Journal of Voice Author(s): Ewelina Sielska-Badurek, Anna Rzepakowska, Maria Sobol, Ewa Osuch-Wójcikiewicz, Kazimierz Niemczyk ObjectivesThe purpose of the study was to translate and adapt the original V-RQOL (Voice-Related Quality of Life) instrument into Polish and to evaluate the psychometric properties of the Polish version of the V-RQOL Measure […]
Vocal and Neural Responses to Unexpected Changes in Voice Pitch Auditory Feedback During Register Transitions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 28 December 2015 Source:Journal of Voice Author(s): Sona Patel, Anjli Lodhavia, Saul Frankford, Oleg Korzyukov, Charles R. Larson Objective/HypothesisIt is known that singers are able to control their voice to maintain a relatively constant vocal quality while transitioning between vocal registers; however, the neural mechanisms underlying this effect are not understood. […]
Teachers’ Perception of Vocal Quality Compared With Professional Perception
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 28 December 2015 Source:Journal of Voice Author(s): Ellie Selevan, Esther Schorr, Rachel Pekarsky, Sheila Mitta, Sara Diamont, Elisheva Stept, Gisele Oliveira PurposeThe purpose of this study was to investigate the difference in teachers’ self-perception of their own voices compared with a voice clinician’s perceptual assessment.MethodsParticipants included 45 elementary school (grades 1–8) […]
Measurement Reliability of Phonation Quotient Derived From Three Aerodynamic Instruments
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 28 December 2015 Source:Journal of Voice Author(s): Ashwini Joshi, Christopher R. Watts ObjectiveThe purpose of this study was to examine parallel forms reliability between two hand-held spirometers and a pneumotachograph-based system for vital capacity and derived phonation quotient measurements.Study designThis is a prospective, repeated measures design.MethodsA total of 20 adult males […]
CT-guided percutaneous microwave ablation treatment for lung metastases from nasopharyngeal carcinoma
Computed tomography-guided percutaneous microwave ablation treatment for lung metastases from nasopharyngeal carcinoma: *H Qi, C Wan, X Li, L Zhang, Z Song, W Fan* Indian Journal of Cancer 2015 52(6):91-95 Background: The objective of this retrospective study was to evaluate the safety and efficacy of percutaneous microwave ablation (MWA) for treating lung metastases from nasopharyngeal carcinoma (NPC). Patients and Methods: From December 2012 to November 2014, 17 patients (15 males, and two females, averaged 45.7 years old) with lung metastases from NPC accepted computed tomog... περισσότερα »
Chlamydia pneumoniae infection and lung cancer risk
A meta-analysis of the association between Chlamydia pneumoniae infection and lung cancer risk: *X Hua-Feng, W Yue-Ming, L Hong, D Junyi* Indian Journal of Cancer 2015 52(6):112-115 Objective: The association between Chlamydia pneumoniae infection and lung cancer risk was not clear with small number of cases in each study. The aim of this meta-analysis was to evaluate the correlation between pneumonia infection and lung cancer risk by pooling the open published papers. Materials and Methods: We searched the electronic databases of Medline, EMBASE, Web of Science, and China Natio... περισσότερα »
Platinum-based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy
Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension: Abstract Cancer chemotherapy with platinum-based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy. We evaluated the antinociceptive effects of the alpha-2 adrenoceptor agonist, clonidine on oxaliplatin-induced neuropathic pain. Specifically, we determined if (1) the intraperitoneal(i.p.) injection of clonidine reduces me... περισσότερα »
Immunogenicity of Influenza Vaccination in Patients With Cancer.
Immunogenicity of Influenza Vaccination in Patients With Cancer.: Background: Influenza leads to significant morbidity and mortality in patients with cancer. Patients with cancer receiving chemotherapy may not mount an adequate immune response to the vaccine. We performed this pilot study to evaluate the immunogenicity of influenza vaccination in patients with cancer receiving chemotherapy. Materials and Methods: During the 2011 to 2012 influenza season, patients undergoing chemotherapy for solid tumors were given trivalent inactivated influenza vaccine either on the day of chemother...περισσότερα »
Regulation of G0/G1 Switch Gene 2 (G0S2) Expression in Human Adipose Tissue.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Regulation of G0/G1 Switch Gene 2 (G0S2) Expression in Human Adipose Tissue. Arch Physiol Biochem. 2015 Dec 26;:1-25 Authors: Skopp A, May M, Janke J, Kielstein H, Wunder R, Flade-Kuthe R, Kuthe A, Jordan J, Engeli S Abstract The G0S2 protein attenuated adipose triglyceride lipase activity and decreased lipolysis in rodent and human adipocytes. We […]
Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:Auris Nasus Larynx Author(s): Hideaki Shirasaki, Etsuko Kanaizumi, Tetsuo Himi ObjectiveAdrenergic receptors (ARs) include four general types (α1, α2, β1 and β2), which are found in different target tissues. α-AR agonists are commonly used for decongestant therapy of upper airway diseases. In order to clarify the roles of […]
Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmp(gt/gt) mice.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmp(gt/gt) mice. Arch Physiol Biochem. 2015 Dec 26;:1-32 Authors: Kong XY, Feng YZ, Eftestøl E, Kase ET, Haugum H, Eskild W, Rustan AC, Thoresen GH Abstract Glycosylated lysosomal membrane protein (GLMP) has been reported to enhance the expression from a peroxisome proliferator-activated receptor alpha […]
Topical application of timolol decreases the severity and frequency of epistaxis in patients who have previously undergone nasal dermoplasty for hereditary hemorrhagic telangiectasia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:Auris Nasus Larynx Author(s): Keiichi Ichimura, Hisashi Kikuchi, Shoichiro Imayoshi, Mari Shimada Dias ObjectiveHereditary hemorrhagic telangiectasia (HHT) is widely known to cause bleeding that is difficult to control because of the associated vascular wall fragility. Although nasal dermoplasty results in decreased severity and frequency of nasal bleeding in […]
THE EFFECT OF DIETARY CURCUMIN AND CAPSAICIN ON HEPATIC FETUIN-A EXPRESSION AND FAT ACCUMULATION IN RATS FED ON A HIGH-FAT DIET.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
THE EFFECT OF DIETARY CURCUMIN AND CAPSAICIN ON HEPATIC FETUIN-A EXPRESSION AND FAT ACCUMULATION IN RATS FED ON A HIGH-FAT DIET. Arch Physiol Biochem. 2015 Dec 26;:1-29 Authors: Seyithanoğlu M, Öner-İyidoğan Y, Doğru-Abbasoğlu S, Tanrıkulu-Küçük S, Koçak H, Beyhan-Özdaş Ş, Koçak-Toker N Abstract Effects of curcumin (turmeric) and capsaicin (red pepper) on hepatic fat accumulation […]
Temporal bone chondroblastoma totally invisible on MRI
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:Auris Nasus Larynx Author(s): Harukazu Hiraumi, Yoshiki Arakawa, Norio Yamamoto, Tatsunori Sakamoto, Juichi Ito We report a case of temporal bone chondroblastoma that was totally invisible on MRI. The patient was a 64-year-old man who presented with several months history of vertigo. The CT scan with bone window […]
Anaplastic Large-Cell Lymphoma of the Left Ventricle Presenting With Arrhythmia and Cerebral Infarction due to Cardiogenic Embolism
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
from Cancer via ola Kala on Inoreader http://ift.tt/1YLEEaq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1METMtY via IFTTT
Delayed restoration of maximum speech discrimination scores in patients with idiopathic sudden sensorineural hearing loss
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:Auris Nasus Larynx Author(s): Yoshihiro Noguchi, Masatoki Takahashi, Taku Ito, Taro Fujikawa, Yoshiyuki Kawashima, Ken Kitamura ObjectiveTo assess possible delayed recovery of the maximum speech discrimination score (SDS) when the audiometric threshold ceases to change.MethodsWe retrospectively examined 20 patients with idiopathic sudden sensorineural hearing loss (ISSNHL) (gender: 9 […]
A Child With Dyserythropoietic Anemia and Megakaryocyte Dysplasia Due to a Novel 5′UTR GATA1s Splice Mutation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
We describe a child with dyserythropoietic anemia, thrombocytosis, functional platelet defect, and megakaryocyte dysplasia. We show that (i) this constellation of hematopoietic abnormalities was due to a germline mutation within the 5′ untranslated region (5′UTR) of globin transcription factor 1 (GATA1); (ii) the mutation impaired a 5′UTR GATA1 splicing site, with promoted production of the […]
Correlation between olfactory acuity and sinonasal radiological findings in adult patients with chronic rhinosinusitis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Publication date: Available online 29 December 2015 Source:Auris Nasus Larynx Author(s): Takahiro Saito, Kenzo Tsuzuki, Yoriko Yukitatsu, Masafumi Sakagami ObjectiveThis study aimed to clarify the correlation between olfactory disorder severity and radiological findings in patients with chronic rhinosinusitis (CRS) in the preoperative stage.MethodsFrom 2007 to 2014, 272 adult patients (163 men, 109 women; age range […]
Preneoadjuvant and Postneoadjuvant Chemoradiotherapy and Tumor Regression Grade in Patients With Locally Advanced Esophageal Cancer.
Correlation Between Standardized Uptake Value in Preneoadjuvant and Postneoadjuvant Chemoradiotherapy and Tumor Regression Grade in Patients With Locally Advanced Esophageal Cancer.: Purpose: To investigate whether positron emission tomography/computed tomography (PET/CT) initial and restaging imaging predicts for pathologic response measured by tumor regression grade (TRG) after preoperative chemoradiotherapy (CRT) in patients with locally advanced esophageal cancer. Methods: A retrospective review of 220 patients with stage II-III esophageal cancer treated with neoadjuvant CRT foll... περισσότερα »
GM-CSF Antibody Formation in Patients Treated With GM-CSF (Sargramostim) as Adjuvant Therapy of Melanoma.
Biological Effects of Anti-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Antibody Formation in Patients Treated With GM-CSF (Sargramostim) as Adjuvant Therapy of Melanoma.: Objectives: We investigated the development of binding and neutralizing antibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients receiving prolonged therapy with GM-CSF as adjuvant therapy of melanoma and the impact of these antibodies on biological effects. Methods: Fifty-three patients with high-risk melanoma that had been surgically excised were treated with GM-CSF, 125 [m... περισσότερα »
Recurrent cerebrospinal fluid (CSF) rhinorrhea, severe hearing loss, and facial palsy secondary to cerebellar herniation into the internal auditory canal
Gorham–Stout Disease of the Skull Base With Hearing Loss: Dramatic Recovery and Antiangiogenic Therapy: [image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] Gorham–Stout disease (GSD) is a rare disorder of unknown etiology. We present a 6-year-old male with GSD involving the skull base who presented with recurrent cerebrospinal fluid (CSF) rhinorrhea, severe hearing loss, and facial palsy secondary to cerebellar herniation into the internal auditory canal. After 2 months of treatment with pegylated interferon (IFN) α-2b (50 μg/week), his hearing recovered dramatically. Two years la... περισσότερα »
Characteristics of Children With Cancer Discharged or Admitted From the Emergency Department
[image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] Background Emergency department (ED) utilization by children with cancer is poorly understood. Among children with cancer, we explored reasons for ED visits and factors associated with admission within U.S. children's hospitals. Methods A retrospective study of the 2011–2013 Pediatric Health Information System (PHIS) was conducted. Eligible ED visits included those within 365 days from the first inpatient encounter with an International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) code for cancer. P... περισσότερα »
Severe Tumor Lysis Syndrome and Acute Pulmonary Edema Requiring Extracorporeal Membrane Oxygenation Following Initiation of Chemotherapy for Metastatic Alveolar Rhabdomyosarcoma
We present an 8-year-old male with metastatic alveolar rhabdomyosarcoma (ARMS) who developed precipitous cardiopulmonary collapse with severe tumor lysis syndrome (TLS) 48 hr after initiation of chemotherapy. Despite no detectable pulmonary metastases, acute hypoxemic respiratory failure developed, requiring extracorporeal membrane oxygenation (ECMO). Although TLS has been reported in disseminated ARMS, this singular case of life-threatening respiratory deterioration developing after initiation of chemotherapy presented unique therapeutic dilemmas. We review the clinical aspects ... περισσότερα »
MRI Measurements of Iron Load in Transfusion-Dependent Patients: Implementation, Challenges, and Pitfalls
Magnetic resonance imaging (MRI) has played a key role in studies of iron overload in transfusion-dependent patients, providing insights into the relations among liver and cardiac iron loading, iron chelator dose, and morbidity. Currently, there is rapid uptake of these methods into routine clinical practice as part of the management strategy for iron overload in regularly transfused patients. Given the manifold methods of data acquisition and analysis, there are several potential pitfalls that may result in inappropriate decision making. Herein, we review the challenges of estab... περισσότερα »
Hymenoptera Allergy and Mast Cell Activation Syndromes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Mast cell activation syndrome (MCAS) can be diagnosed in patients with recurrent, severe symptoms from mast cell (MC)-derived mediators, which are transiently increased in serum and are attenuated by mediator-targeting drugs. When KIT-mutated, clonal MC are detected in these patients, a diagnosis of primary MCAS can be made. Severe systemic reactions to hymenoptera venom […]
Practical Management of Patients with a History of Immediate Hypersensitivity to Common non-Beta-Lactam Drugs
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Immediate hypersensitivity reactions to medications are among the most feared adverse drug reactions, because of their close association with anaphylaxis. This review discusses a practical management approach for patients with a history of an immediate hypersensitivity to a non-beta-lactam medication, where reexposure to the implicated, or similar, medication is clinically necessary. Mechanisms associated with […]
Heritability of naevus pattern
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The morphological universe of naevi comprises a broad variability of clinical and dermoscopic patterns that are linked to peculiar histological and biological traits. Thus, the resulting naevus morphology is strongly affected by genetic and environmental factors. Twin studies have been used to explore the contribution of the genetics of various phenotypes. This article is […]
PSTPIP1 Gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) Syndrome
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Pyoderma gangrenosum (PG) acne and suppurative hidradenitis (SH) (PASH) syndrome is a recently described condition which belongs to the spectrum of autoinflammatory diseases (AIDs). 1 AIDs are a group of heterozygous disorders characterized by disregulation of the innate immune response. 2PSTPIP1 gene mutations affecting proteins of the inflammasome complex or proteins that regulate it′s […]
Primary amelanotic rhabdoid melanoma of the forehead
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Pathologists in general and dermatopathologist in particular are very well aware that melanomas can virtually mimic any type of cancer due to its huge versatility to adopt many cytomorphological and architectural variants1. In 1992, rhabdoid variant of melanoma was first described by Bittesini et al.2, which is considered an extremely rare variant of malignant […]
The role of PSMB9 up-regulated by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and lupus erythematosus
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Background Dermatomyositis (DM) and systemic lupus erythematosus (SLE) have common skin features, including dermal mucin deposition and interferon signature, although their roles are unknown. Objective To identify common or specific molecular changes in DM and SLE skin. Methods Proteomic analysis was performed utilizing DM and normal subject (NS) skin. Glycosaminoglycans were analyzed by high-performance […]
Celebrations of D-FW athletes present: Dez throwing up the X, Dirk’s tongue … – Dallas Morning News (blog)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dallas Morning News (blog) Celebrations of D-FW athletes present: Dez throwing up the X, Dirk’s tongue … Dallas Morning News (blog) Google «Dirk Nowitzki tongue celebration» and there are hundreds of photos of the Mavs icon pumping his fist or holding three fingers up in the air with his tongue projecting from his mouth. He’s […]
The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 29 December 2015 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Sumeyya Akyol, Haci Kemal Erdemli, Ferah Armutcu, Omer Akyol from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JGVwmE via IFTTT
Congenital midline cervical cleft: A retrospective case series of 8 children
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 29 December 2015 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Sophie Achard, Xavier Leroy, Pierre Fayoux ObjectivesCongenital midline cervical cleft is a rare developmental abnormality of the ventral neck of unclear etiology. It consists of a midline skin defect. This study reports a case series of 8 patients with congenital midline cervical […]
Compliance with Iron-Folate Supplement and Associated Factors among Antenatal Care Attendant Mothers in Misha District, South Ethiopia: Community Based Cross-Sectional Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background. In Ethiopia, higher proportions of pregnant women are anemic. Despite the efforts to reduce iron deficiency anemia during pregnancy, only few women took an iron supplement as recommended. Thus, this study aimed to assess compliance with iron-folate supplement and associated factors among antenatal care attendant mothers in Misha district, South Ethiopia. Method. Community based […]
Care in the home for seriously ill children with complex needs: A narrative literature review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This article reviews contemporary literature on home care of the seriously ill child with complex care needs and the sick child/parent dyad. The literature search revealed three major themes, namely the increasing acuity of child illness, the evolving role of the parent as care provider, and the health professional as care provider. While there is […]
Psychosocial outcomes of a summer overnight recreational experience for children with heart disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Children with chronic heart disease (CHD) are often turned away from recreational summer overnight experiences because of complicated medical histories and medication regimens. The purpose of this qualitative study was to evaluate the psychosocial impact of a five-day overnight recreational experience for children with CHD and their parents. Thirty-six children with CHD between the age […]
Social relationships, loneliness and adolescence: The potential for disruption by chronic illness
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OiIWzg via IFTTT
Nursing culture: An enemy of evidence-based practice? A focus group exploration
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Evidence-based practice (EBP) is challenging for most nurses due to the time constraints of caring for patients and the emerging pressures of a changing health service. To explore these challenges, and thus to establish possible means of overcoming them, three focus groups (n = 17) with children’s nurses were conducted. Participants were asked how they […]
Topical anti-inflammatory activity of Solanum corymbiflorum leaves
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 17 February 2016 Source:Journal of Ethnopharmacology, Volume 179 Author(s): Mariana Piana, Camila Camponogara, Aline Augusti Boligon, Michel Mansur Machado, Thiele Faccim de Brum, Sara Marchesan Oliveira, Liliane de Freitas Bauermann Solanum corymbiflorum is popularly known as “baga-de-veado” and its leaves are applied on inflamed legs, scabies, tick bite, boils, mastitis, low back pain […]
α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of franki ncense by inhibiting COX-2
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 17 February 2016 Source:Journal of Ethnopharmacology, Volume 179 Author(s): Xiao-Jun Li, Yan-Jing Yang, Yu-Sang Li, Wei Kevin Zhang, He-Bin Tang Ethnopharmacological relevanceFrankincense oil and water extracts (FOE, FWE) have long been used for external treatment of inflammation and pain. The present study was conducted to identify the active ingredients responsible for the anti-inflammatory […]
Identifying Chinese herbal medicine network for treating acne: Implications from a nationwide database
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 17 February 2016 Source:Journal of Ethnopharmacology, Volume 179 Author(s): Hsing-Yu Chen, Yi-Hsuan Lin, Yu-Chun Chen Ethno-pharmacological relevanceAcne is a highly prevalent inflammatory skin disease which causes patients great psychological stress, especially teenagers. Chinese herbal medicine (CHM) is commonly used to treat acne with personalized but complicated prescriptions. The aim of this study is […]
Evaluation of the use of Ocimum suave Willd. (Lamiaceae), Plectranthus barbatus Andrews (Lamiaceae) and Zanthoxylum chalybeum Engl. (Rutaceae) as antimalarial remedies in Kenyan folk medicine
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 3 February 2016 Source:Journal of Ethnopharmacology, Volume 178 Author(s): Micheni N. Kiraithe, Joseph M. Nguta, James M. Mbaria, Stephen G. Kiama Ethnopharmacological relevanceCrude extracts from the leaves of Ocimum suave Willd (Lamiaceae) and the root barks of Plectranthus barbatus Andrews (Lamiaceae) and Zanthoxylum chalybeum Engl. (Rutaceae) were studied to ascertain the ethnopharmacological standing […]
Investigation of traditional medicinal floral knowledge of Sarban Hills, Abbottabad, KP, Pakistan
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 29 December 2015 Source:Journal of Ethnopharmacology Author(s): Farhana Ijaz, Zafar Iqbal, Inayat Ur Rahman, Jan Alam, Shujaul Mulk Khan, Ghulam Mujtaba Shah, Khalid Khan, Aftab Afzal Ethno pharmacological relevanceEthno medicinal traditional knowledge regarding the uses of indigenous medicinal plants for treating various human infectious diseases is totally in hold of the […]
Therapie des Pruritus bei inneren Erkrankungen: Was ist gesichert?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Chronischer Juckreiz Mehr als 15 % aller Menschen in Deutschland leiden unter chronischem Pruritus. Neben den klassischen atopischen Erkrankungen und anderen juckenden Hauterkrankungen sind auch Patienten mit chronischen Nieren-, Leber- oder hämatologischen Erkrankungen betroffen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NNX1TX via IFTTT
Hymenoptera Allergy and Mast Cell Activation Syndromes
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Mast cell activation syndrome (MCAS) can be diagnosed in patients with recurrent, severe symptoms from mast cell (MC)-derived mediators, which are transiently increased in serum and are attenuated by mediator-targeting drugs. When KIT-mutated, clonal MC are detected in these patients, a diagnosis of primary MCAS can be made. Severe systemic reactions to hymenoptera venom […]
Practical Management of Patients with a History of Immediate Hypersensitivity to Common non-Beta-Lactam Drugs
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Immediate hypersensitivity reactions to medications are among the most feared adverse drug reactions, because of their close association with anaphylaxis. This review discusses a practical management approach for patients with a history of an immediate hypersensitivity to a non-beta-lactam medication, where reexposure to the implicated, or similar, medication is clinically necessary. Mechanisms associated with […]
Reappraisal of hMLH1 promoter methylation and protein expression status in the serrated neoplasia pathway
Abstract Aims The aim of this study was to determine whether hMLH1 inactivation precedes the progression of sessile serrated lesion (SSL) into SSL with cytologic dysplasia (SSL/D) and to define the histologic stage at which promoter methylation and inactivation of hMLH1 occur. Methods and results By using the MassARRAY EpiTYPER assay and immunohistochemistry, we examined methylation levels and the protein expression status of hMLH1 in 33 SSL/Ds with conventional epithelial dysplasia and compared the results with those of control hyperplastic polyps (HPs) and SSLs. The methylation... περισσότερα »
[A rare case of lateral cervical mass in children].
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *[A rare case of lateral cervical mass in children].* Arch Pediatr. 2015 Mar;22(3):309-10, 320-2 Authors: Eliezer M, Marie JP, Dacher JN, Vivier PH PMID: 25636212 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1YLtW3N via IFTTT
Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix.
*Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix.* Acta Histochem. 2015 Dec 18; Authors: Gao M, Li Y, Ji X, Xue X, Chen L, Feng G, Zhang H, Wang H, Shah W, Hou Z, Kong Y Abstract Epidemiological studies have demonstrated that cigarette smoking is an important cofactor or an independent risk factor for the development of cervical cancer. Benzo(a)pyrene (BaP) is one of the most potent tobacco smoke carcinogens in tobacco smoke. BaP induced DNA damage and over expression in p53 cervical tissue of mice as ...περισσότερα »
Protective effects of mito-TEMPO against doxorubicin cardiotoxicity
Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice: Abstract PurposeDoxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO (mito-T) as a protective agent against DOX-induced cardiotoxicity in mice. MethodsC57BL/6 mice were treated twice with mito-T at low (5 mg/kg body weight) or high (20 mg/kg body weight) dose and once with DOX (24 mg/kg body weight) or saline (0....περισσότερα »
How effective is postoperative packing in FESS patients? A critical analysis of published interventional studies.
*How effective is postoperative packing in FESS patients? A critical analysis of published interventional studies.* Eur Arch Otorhinolaryngol. 2015 Dec 26; Authors: Vlastarakos PV, Iacovou E, Fetta M, Tapis M, Nikolopoulos TP Abstract The present study aimed to assess the clinical effectiveness of absorbable packing alone, non-absorbable packing alone, and absorbable versus non-absorbable packing in the postoperative care of FESS patients, regarding bleeding control, adhesion formation, wound healing, and overall patient comfort. Systematic literature review in Medline and other ... περισσότερα »
upper respiratory tract infection; +46 new citations
46 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2015/12/29 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/QGMHBq(((upper%20respiratory%20tract%20infection)%20AND%20%222015%2F12%2... περισσότερα »
Effect of liquid to solid lipid ratio on characterizations of flurbiprofen-loaded solid lipid nanoparticles(SLN) and nanostructured lipid carriers (NLC) for transdermal administration.
*Effect of liquid to solid lipid ratio on characterizations of flurbiprofen-loaded solid lipid nanoparticles(SLN) and nanostructured lipid carriers (NLC) for transdermal administration.* Drug Dev Ind Pharm. 2015 Dec 28;:1-26 Authors: Song A, Zhang X, Li Y, Mao X, Han F Abstract The aim of this study is to evaluate the effect of liquid to solid lipid ratio on properties of flurbiprofen-loaded solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), and to clarify the superiority of NLC over SLN for transdermal administration. Particle size, zeta potential, drug en... περισσότερα »
Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy.
*Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy.* Acta Pharmacol Sin. 2015 Dec 28; Authors: Zhang YS, Shen Q, Li J Abstract Esophageal cancer is one of the most common types of cancer in the world, and it demonstrates a distinct geographical distribution pattern in China. In the last decade, inducing apoptosis with traditional Chinese medicine (TCM) has become an active area in both fundamental and clinical research on cancer therapy. In this review, we summarize the molecular mechanisms by which TCM induces apoptosis in esophageal canc...περισσότερα »
Risk Factors Associated with Ipsilateral Ischemic Events Following Carotid Endarterectomy (CEA) for Carotid Artery Stenosis.
*Risk Factors Associated with Ipsilateral Ischemic Events Following Carotid Endarterectomy (CEA) for Carotid Artery Stenosis.* World Neurosurg. 2015 Dec 17; Authors: Rong X, Yang W, Garzon-Muvdi T, Ye X, Caplan JM, Colby GP, Coon AL, Tamargo RJ, Huang J Abstract OBJECTIVE: Patients undergoing carotid endarterectomy (CEA) are at risk of developing ipsilateral stroke or transient ischemic attacks (TIA). In this study, we explored factors associated with development of these events following CEA in patients with long-term follow-up. METHODS: We performed a retrospective analysis of ...περισσότερα »
Diagnostic Value of Somatosensory Evoked Potential Monitoring During Cerebral Aneurysm Clipping.
*Diagnostic Value of Somatosensory Evoked Potential Monitoring During Cerebral Aneurysm Clipping.* World Neurosurg. 2015 Dec 17; Authors: Thirumala PD, Udesh R, Muralidharan A, Thiagarajan K, Crammond DJ, Balzer JR, Chang YF Abstract BACKGROUND: Perioperative stroke is a known complication in patients undergoing surgical clipping of cerebral aneurysms. OBJECTIVE: To evaluate whether intra-operative changes in somatosensory evoked potential (SSEP) monitoring during cerebral aneurysm clipping is diagnostic of perioperative stroke. METHODS: An electronic search of PubMed, Embase and... περισσότερα »
Epilepsy: A Disruptive Force in History.
*Epilepsy: A Disruptive Force in History.* World Neurosurg. 2015 Dec 17; Authors: Ali R, Connolly ID, Feroze AH, Awad AJ, Choudhri OA, Grant GA Abstract Since first described in a Mesopotamian text in 2000 BC, countless individuals have offered their perspectives on epilepsy's cause, treatment, and even deeper spiritual significance. However, despite the attention the disease has received through the millennia, it has only been within the past half-century that truly effective treatment options have been available. As a result, for the vast majority of recorded history, individu... περισσότερα »
Endoscopic Resection of Intraventricular Brain Tumors in Children.
*Endoscopic Resection of Intraventricular Brain Tumors in Children.* World Neurosurg. 2015 Dec 17; Authors: Sandberg DI PMID: 26709154 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1mNuzsD via IFTTT
Deafferentation-based pathophysiological differences in phantom sound: Tinnitus with and without hearing loss.
*Deafferentation-based pathophysiological differences in phantom sound: Tinnitus with and without hearing loss.* Neuroimage. 2015 Dec 18; Authors: Vanneste S, De Ridder D Abstract Tinnitus has been considered an auditory phantom percept. Recently a theoretical multiphase compensation mechanism at a cortical level has been hypothesized linking auditory deafferentation to tinnitus. This Bayesian brain model predicts that two very different kinds of tinnitus should exist, depending on the amount of hearing loss: an auditory cortex related form of tinnitus not associated with hearin...περισσότερα »
Resting Energy Expenditure is Decreased in Pseudohypoparathyroidism Type 1A.
*Resting Energy Expenditure is Decreased in Pseudohypoparathyroidism Type 1A.* J Clin Endocrinol Metab. 2015 Dec 28;:jc20153895 Authors: Roizen JD, Danzig J, Groleau V, McCormack S, Casella A, Harrington J, Sochett E, Tershakovec A, Zemel BS, Stallings VA, Levine MA Abstract CONTEXT: Pseudohypoparathyroidism type 1A (PHP1A) is caused by loss-of function mutations on the maternally-inherited GNAS allele, and is associated with early-onset obesity, neurocognitive defects and resistance to multiple hormones. The role of energy intake versus central regulation of energy expenditure ...περισσότερα »
Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults.
*Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults.* J Clin Endocrinol Metab. 2015 Dec 28;:jc20153525 Authors: Rauschert S, Uhl O, Koletzko B, Kirchberg F, Mori TA, Huang RC, Beilin LJ, Hellmuth C, Oddy WH Abstract CONTEXT: Obesity and related diseases have become a global public health burden. Identifying biomarkers will lead to a better understanding of the underlying mechanisms associated with obesity and the pathways leading to insulin resistance (IR) and diabetes. OBJECTIVE: This study aimed to identify lipidomic biomarkers ...περισσότερα »
PREDICTORS OF WHOLE-BODY INSULIN SENSITIVITY ACROSS AGES AND ADIPOSITY IN ADULT HUMANS.
*PREDICTORS OF WHOLE-BODY INSULIN SENSITIVITY ACROSS AGES AND ADIPOSITY IN ADULT HUMANS.* J Clin Endocrinol Metab. 2015 Dec 28;:jc20152892 Authors: Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR Abstract CONTEXT: Numerous factors are purported to influence insulin sensitivity including age, adiposity, mitochondrial function, and physical fitness. Univariate associations cannot address the complexity of insulin resistance syndrome or the interrelationship among potential determinants. OBJECTIVE: To identify... περισσότερα »
Resting Energy Expenditure is Decreased in Pseudohypoparathyroidism Type 1A.
*Resting Energy Expenditure is Decreased in Pseudohypoparathyroidism Type 1A.* J Clin Endocrinol Metab. 2015 Dec 28;:jc20153895 Authors: Roizen JD, Danzig J, Groleau V, McCormack S, Casella A, Harrington J, Sochett E, Tershakovec A, Zemel BS, Stallings VA, Levine MA Abstract CONTEXT: Pseudohypoparathyroidism type 1A (PHP1A) is caused by loss-of function mutations on the maternally-inherited GNAS allele, and is associated with early-onset obesity, neurocognitive defects and resistance to multiple hormones. The role of energy intake versus central regulation of energy expenditure ...περισσότερα »
Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults.
*Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults.* J Clin Endocrinol Metab. 2015 Dec 28;:jc20153525 Authors: Rauschert S, Uhl O, Koletzko B, Kirchberg F, Mori TA, Huang RC, Beilin LJ, Hellmuth C, Oddy WH Abstract CONTEXT: Obesity and related diseases have become a global public health burden. Identifying biomarkers will lead to a better understanding of the underlying mechanisms associated with obesity and the pathways leading to insulin resistance (IR) and diabetes. OBJECTIVE: This study aimed to identify lipidomic biomarkers ...περισσότερα »
PREDICTORS OF WHOLE-BODY INSULIN SENSITIVITY ACROSS AGES AND ADIPOSITY IN ADULT HUMANS.
*PREDICTORS OF WHOLE-BODY INSULIN SENSITIVITY ACROSS AGES AND ADIPOSITY IN ADULT HUMANS.* J Clin Endocrinol Metab. 2015 Dec 28;:jc20152892 Authors: Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR Abstract CONTEXT: Numerous factors are purported to influence insulin sensitivity including age, adiposity, mitochondrial function, and physical fitness. Univariate associations cannot address the complexity of insulin resistance syndrome or the interrelationship among potential determinants. OBJECTIVE: To identify... περισσότερα »
Vestibular evoked myogenic potential testing for the diagnosis of conductive hearing loss: survey of pediatric otolaryngologists' knowledge and beliefs.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Vestibular evoked myogenic potential testing for the diagnosis of conductive hearing loss: survey of pediatric otolaryngologists' knowledge and beliefs.* Int J Pediatr Otorhinolaryngol. 2014 Nov;78(11):1937-9 Authors: Dargie JM, Zhou G, Dornan BK, Whittemore KR Abstract OBJECTIVES: To assess physicians' knowledge and beliefs regarding vestibular evoked myogenic potential (VEMP) testing in children. METHODS: A survey was delivered via email in html format to 1069 members of the American Academy of Otolaryngology--H... περισσότερα »
Peripheral facial palsy, the only presentation of a primitive neuroectodermal tumor of the skull base.
*Peripheral facial palsy, the only presentation of a primitive neuroectodermal tumor of the skull base.* Int J Surg Case Rep. 2015 Dec 17;19:47-50 Authors: Kim HJ, Kang B, Joo EY, Kim EY, Kwon YS Abstract INTRODUCTION: Peripheral facial palsy is rarely caused by primary neoplasms, which are mostly constituted of tumors of the central nervous system, head and neck, and leukemia. PRESENTATION OF CASE: A 2-month-old male infant presented with asymmetric facial expression for 3 weeks. Physical examination revealed suspicious findings of right peripheral facial palsy. Computed tomogra... περισσότερα »
Intracranial Facial Nerve Grafting in the Setting of Skull Base Tumors: Global and Regional Facial Function Analysis and Possible Implications for Facial Reanimation Surgery.
*Intracranial Facial Nerve Grafting in the Setting of Skull Base Tumors: Global and Regional Facial Function Analysis and Possible Implications for Facial Reanimation Surgery.* Plast Reconstr Surg. 2016 Jan;137(1):267-278 Authors: Rozen SM, Harrison BL, Isaacson B, Kutz JW, Roland PS, Blau PA, Barnett SL, Mickey BE Abstract BACKGROUND: Reconstructive surgeons may encounter patients presenting after intracranial facial nerve resection and grafting in the setting of skull base tumors, who inquire regarding progression, final facial function, and need for future operations. Study g... περισσότερα »
Congenital abnormalities of the posterior fossa.
Related Articles *Congenital abnormalities of the posterior fossa.* Radiographics. 2015 Jan-Feb;35(1):200-20 Authors: Bosemani T, Orman G, Boltshauser E, Tekes A, Huisman TA, Poretti A Abstract The frequency and importance of the evaluation of the posterior fossa have increased significantly over the past 20 years owing to advances in neuroimaging. Nowadays, conventional and advanced neuroimaging techniques allow detailed evaluation of the complex anatomic structures within the posterior fossa. A wide spectrum of congenital abnormalities has been demonstrated, including malformat... περισσότερα »
Animal models of chronic tympanic membrane perforation: a 'time-out' to review evidence and standardize design.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Animal models of chronic tympanic membrane perforation: a 'time-out' to review evidence and standardize design.* Int J Pediatr Otorhinolaryngol. 2014 Dec;78(12):2048-55 Authors: Wang AY, Shen Y, Wang JT, Friedland PL, Atlas MD, Dilley RJ Abstract OBJECTIVE: To review the literature on techniques for creation of chronic tympanic membrane perforations (TMP) in animal models. Establishing such models in a laboratory setting will have value if they replicate many of the properties of the human clinical condition and c... περισσότερα »
Intramuscular innervations of lower leg skeletal muscles: applications in their clinical use in functional muscular transfer.
*Intramuscular innervations of lower leg skeletal muscles: applications in their clinical use in functional muscular transfer.* Surg Radiol Anat. 2015 Dec 26; Authors: Yu D, Yin H, Han T, Jiang H, Cao X Abstract PURPOSE: This study aims to investigate nerve distribution patterns of human lower leg skeletal muscles using a modified Sihler's staining method. METHODS: Sixteen lower leg from eight fresh adult cadavers were used in this study and all the skeletal muscles were dissected. The muscle specimens were classified according to Lim's classification. The specimens were then sta...περισσότερα »
An unexpected finding in the resection specimen of a carcinoma of the oral cavity: A case report.
*An unexpected finding in the resection specimen of a carcinoma of the oral cavity: A case report.* Int J Surg Case Rep. 2015 Dec 17;19:55-59 Authors: Olthof DC, Bun RJ, Dutrieux RP, Houdijk AP Abstract INTRODUCTION: The occurrence of two synchronous, primary cancers is rare. Thyroid carcinoma is incidentally found in the resection specimen after surgery for head and neck cancer in 0.3-1.9% of the patients. PRESENTATION OF CASE: In this report, we describe the case of a 72-year-old patient in whom a primary (synchronous) papillary thyroid carcinoma was found coincidentally upon p...περισσότερα »
Reappraisal of hMLH1 promoter methylation and protein expression status in the serrated neoplasia pathway
Abstract Aims The aim of this study was to determine whether hMLH1 inactivation precedes the progression of sessile serrated lesion (SSL) into SSL with cytologic dysplasia (SSL/D) and to define the histologic stage at which promoter methylation and inactivation of hMLH1 occur. Methods and results By using the MassARRAY EpiTYPER assay and immunohistochemistry, we examined methylation levels and the protein expression status of hMLH1 in 33 SSL/Ds with conventional epithelial dysplasia and compared the results with those of control hyperplastic polyps (HPs) and SSLs. The methylation... περισσότερα »
Role of a multimodal educational strategy on health care workers' handwashing
Publication date: Available online 28 December 2015 *Source:*American Journal of Infection Control Author(s): Jo Andrea Watson BackgroundGood hand hygiene is the single most important strategy used to prevent health care–associated infections (HAIs); however, health care workers' (HCWs') hand hygiene compliance rates range between 25% and 51%. This study aims to determine if a multimodal strategy using the World Health Organization's (WHO's) My 5 Moments for Hand Hygiene methodology increases HCWs' compliance with handwashing and awareness of the importance of good hand hygiene in t... περισσότερα »
Recovery of resistant bacteria from mattresses of patients under contact precautions
Publication date: Available online 28 December 2015 *Source:*American Journal of Infection Control Author(s): Roberta El Hariri Viana, Simone G. dos Santos, Adriana C. Oliveira BackgroundMicroorganisms may contaminate hospital mattresses even after terminal cleaning. We investigated the recovery of resistant bacteria from the mattresses of patients under contact precautions at a university hospital.MethodsWe conducted a cross-sectional study. Samples were obtained from the surface of mattresses, spread on replicate organism detection and counting plates, and cultivated at 37°C for 4...περισσότερα »
Antiretroviral therapy among pregnant and postpartum women in China: A systematic review and meta-analysis
Publication date: Available online 28 December 2015 *Source:*American Journal of Infection Control Author(s): Huan Zhou, Lu Liu, Min Zhang, Xingzhi Chen, Zhaohui Huang BackgroundThe objectives of this study were to estimate the antiretroviral therapy (ART) rate and the proportion of women with adequate ART adherence (100%), and to identify the reasons for not initiating ART in HIV-infected pregnant women in China.MethodsWe searched MEDLINE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wanfang (Chinese) to identify research studies published fro...περισσότερα »
PSTPIP1 Gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) Syndrome
Abstract Pyoderma gangrenosum (PG) acne and suppurative hidradenitis (SH) (PASH) syndrome is a recently described condition which belongs to the spectrum of autoinflammatory diseases (AIDs). 1 AIDs are a group of heterozygous disorders characterized by disregulation of the innate immune response. 2 *PSTPIP1* gene mutations affecting proteins of the inflammasome complex or proteins that regulate it′s function, responsible for the inflammatory pathway, are associated with AIDs. This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis o...περισσότερα »
Primary amelanotic rhabdoid melanoma of the forehead
Abstract Pathologists in general and dermatopathologist in particular are very well aware that melanomas can virtually mimic any type of cancer due to its huge versatility to adopt many cytomorphological and architectural variants1. In 1992, rhabdoid variant of melanoma was first described by Bittesini et al.2, which is considered an extremely rare variant of malignant melanoma, better observed in metastatic cases rather than primary melanomas3. Histopathologically is characterized by the presence of large sheets or nests of polygonal tumor cells with abundant cytoplasm containing ... περισσότερα »
The role of PSMB9 up-regulated by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and lupus erythematosus
Summary Background Dermatomyositis (DM) and systemic lupus erythematosus (SLE) have common skin features, including dermal mucin deposition and interferon signature, although their roles are unknown. Objective To identify common or specific molecular changes in DM and SLE skin. Methods Proteomic analysis was performed utilizing DM and normal subject (NS) skin. Glycosaminoglycans were analyzed by high-performance liquid chromatography. Results The expressions of 61 proteins were upregulated or downregulated in DM skin compared to NS skin in the proteomic analysis. Among those pr... περισσότερα »
Coffee consumption and the risk of incident gastric cancer-A meta-analysis of prospective cohort studies.
*Coffee consumption and the risk of incident gastric cancer-A meta-analysis of prospective cohort studies.* Nutr Cancer. 2015 Dec 28;:1-8 Authors: Deng W, Yang H, Wang J, Cai J, Bai Z, Song J, Zhang Z Abstract As several epidemiological studies on the association of coffee consumption with gastric cancer risk have produced inconsistent results, this meta-analysis was designed to synthesize current evidence of this potential relationship. We searched PubMed, EMBASE, and the Cochrane Library up to September 2014 to retrieve relevant articles. Prospective cohort studies were includ...περισσότερα »
Does the small fit them all? The utility of Disabkids-10 Index for the assessment of pediatric health-related quality of life across age-groups, genders, and informants
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The objective of this study was twofold: First, to conduct a confirmatory factor analysis of the Portuguese versions of Disabkids-10; and second, to examine potential differences in factor structures between age-groups, genders, and informants. The sample included 293 school-aged children and adolescents with chronic health conditions and 197 parents. Both family members (whenever possible) completed […]
A rare case of lateral cervical mass in children.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles [A rare case of lateral cervical mass in children]. Arch Pediatr. 2015 Mar;22(3):309-10, 320-2 Authors: Eliezer M, Marie JP, Dacher JN, Vivier PH PMID: 25636212 [PubMed – indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1YLtW3N via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on […]
Care in the home for seriously ill children with complex needs: A narrative literature review
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
This article reviews contemporary literature on home care of the seriously ill child with complex care needs and the sick child/parent dyad. The literature search revealed three major themes, namely the increasing acuity of child illness, the evolving role of the parent as care provider, and the health professional as care provider. While there is […]
Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix. Acta Histochem. 2015 Dec 18; Authors: Gao M, Li Y, Ji X, Xue X, Chen L, Feng G, Zhang H, Wang H, Shah W, Hou Z, Kong Y Abstract Epidemiological studies have demonstrated that cigarette smoking is […]
Psychosocial outcomes of a summer overnight recreational experience for children with heart disease
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Children with chronic heart disease (CHD) are often turned away from recreational summer overnight experiences because of complicated medical histories and medication regimens. The purpose of this qualitative study was to evaluate the psychosocial impact of a five-day overnight recreational experience for children with CHD and their parents. Thirty-six children with CHD between the age […]
Prediction of gene expression and codon usage in human parasitic helminths
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Codon usage bias refers to the differences in the occurrence frequency of synonymous codons. To understand the patterns of codon usage in mitochondrial genes we used bioinformatic approaches to analyze the protein coding sequences of W. bancrofti and S. haematobium as no work was reported earlier. It was found that the ENC value ranged […]
Social relationships, loneliness and adolescence: The potential for disruption by chronic illness
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OiIWzg via IFTTT
Perception of ‘mothers of beneficiaries’ regarding a rural community based hearing screening service.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Perception of ‘mothers of beneficiaries’ regarding a rural community based hearing screening service. Int J Pediatr Otorhinolaryngol. 2014 Dec;78(12):2083-8 Authors: Akilan R, Vidya R, Roopa N Abstract UNLABELLED: A rural community-based hearing screening project was established in villages in a rural district of Tamil Nadu in South India. The goal of this project […]
Nursing culture: An enemy of evidence-based practice? A focus group exploration
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Evidence-based practice (EBP) is challenging for most nurses due to the time constraints of caring for patients and the emerging pressures of a changing health service. To explore these challenges, and thus to establish possible means of overcoming them, three focus groups (n = 17) with children’s nurses were conducted. Participants were asked how they […]
Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 29 December 2015 Source:Hearing Research Author(s): David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Luke Campbell, Stephen O’Leary Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks […]
Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning inflammatory cells and production of coagulation factors in blistering diseases. Skin biopsies were taken from 14 patients with DH, 27 with BP, and 20 control subjects. The localization and expression of tissue factor (TF) in skin lesions and perilesional skin were studied by im... περισσότερα »
Perception of 'mothers of beneficiaries' regarding a rural community based hearing screening service.
[image: http:--linkinghub.elsevier.com-ihub-imag]Related Articles *Perception of 'mothers of beneficiaries' regarding a rural community based hearing screening service.* Int J Pediatr Otorhinolaryngol. 2014 Dec;78(12):2083-8 Authors: Akilan R, Vidya R, Roopa N Abstract UNLABELLED: A rural community-based hearing screening project was established in villages in a rural district of Tamil Nadu in South India. The goal of this project was to address early detection of hearing loss among infants and young children. Village health workers (VHW) were trained to conduct hearing screenings ... περισσότερα »
Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Luke Campbell, Stephen O’Leary Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This study tested whether this “delayed” hearing loss was influenced by the route of electrode array in...περισσότερα »
Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Luke Campbell, Stephen O’Leary Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This study tested whether this “delayed” hearing loss was influenced by the route of electrode array in...περισσότερα »
Research Supported by the Tinnitus Research Consortium
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): Allen F. Ryan, Robert A. Dobie, Judy R. Dubno, Brenda L. Lonsbury-Martin from #Audiology via xlomafota13 on Inoreader http://ift.tt/1RPfvXZ via IFTTT
Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Luke Campbell, Stephen O’Leary Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This study tested whether this “delayed” hearing loss was influenced by the route of electrode array in...περισσότερα »
Research Supported by the Tinnitus Research Consortium
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): Allen F. Ryan, Robert A. Dobie, Judy R. Dubno, Brenda L. Lonsbury-Martin from #Audiology via ola Kala on Inoreader http://ift.tt/1RPfvXZ via IFTTT
Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Luke Campbell, Stephen O’Leary Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This study tested whether this “delayed” hearing loss was influenced by the route of electrode array in...περισσότερα »
Research Supported by the Tinnitus Research Consortium
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): Allen F. Ryan, Robert A. Dobie, Judy R. Dubno, Brenda L. Lonsbury-Martin from #Audiology via ola Kala on Inoreader http://ift.tt/1RPfvXZ via IFTTT
Research Supported by the Tinnitus Research Consortium
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): Allen F. Ryan, Robert A. Dobie, Judy R. Dubno, Brenda L. Lonsbury-Martin from #Audiology via ola Kala on Inoreader http://ift.tt/1RPfvXZ via IFTTT
Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): David Rowe, Scott Chambers, Amy Hampson, Hayden Eastwood, Luke Campbell, Stephen O’Leary Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This study tested whether this “delayed” hearing loss was influenced by the route of electrode array in...περισσότερα »
Research Supported by the Tinnitus Research Consortium
Publication date: Available online 29 December 2015 *Source:*Hearing Research Author(s): Allen F. Ryan, Robert A. Dobie, Judy R. Dubno, Brenda L. Lonsbury-Martin from #Audiology via ola Kala on Inoreader http://ift.tt/1RPfvXZ via IFTTT
Social Cognitive Correlates of Physical Activity in African-Americans with Multiple Sclerosis
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 29 December 2015 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Dominique Kinnett-Hopkins, Robert W. Motl ObjectiveTo examine variables from social-cognitive theory as correlates of physical activity in African-Americans and Caucasians with MS.DesignCross-sectionalSettingNational surveyParticipants151 African-American and 185 Caucasians with MS were recruited through the NARCOMS registry.Main Outcome MeasuresThe battery of questionnaires included information on demographic and clinical characteristics, physical activity, exerc... περισσότερα »
Evaluating individual change with the Quality of Life in Neurological Disorders (Neuro-QoL) Short Forms
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 29 December 2015 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Allan J. Kozlowski, David Cella, Kristian P. Nitsch, Allen W. Heinemann ObjectiveTo provide a clinically useful means of interpreting change for individual patients on the Neurological Quality of Life (Neuro-QoL) adult short forms (SFs) by applying a Classical Test Theory concept for interpreting individual change.DesignSecondary analysis of existing data.SettingCommunity.ParticipantsPersons with neurological conditions including stroke, epilepsy, amyotrophic late...περισσότερα »
Prediction of gene expression and codon usage in human parasitic helminths
Abstract Codon usage bias refers to the differences in the occurrence frequency of synonymous codons. To understand the patterns of codon usage in mitochondrial genes we used bioinformatic approaches to analyze the protein coding sequences of *W. bancrofti* and *S. haematobium* as no work was reported earlier. It was found that the ENC value ranged from 43 to 60 with a mean of 46.91 in *W. bancrofti* but varied from 49 to 60 with a mean of 45.17 in *S. haematobium*, respectively. In *W. bancrofti* a significant positive correlation was found between ENC and GC3% (r = 0.826**, p < ... περισσότερα »
A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
In this study, we hypothesized that single nucleotide polymorphisms (SNPs) at the micro RNA (miRNA)-binding sites of DSB repair genes may influence cancer risk by dysregulating target gene expression. To test our hypothesis, we firstly performed functional prediction for common SNPs in DSB genes and found 12 potentially functional SNPs located at the miRNA-binding sites. […]
Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Carbonic anhydrase 8 (CA8), a member of the carbonic anhydrase family, is one of the three isozymes that do not catalyze the reversible hydration of carbon dioxide due to the lack of one important histidine. In the present study, we observed increased expression of CA8 in more aggressive types of human osteosarcoma (OS) cells […]
MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Esophageal cancer is a malignant disease with poor prognosis, increasing incidence, and ineffective treatment options. MicroRNAs are post-transcriptional regulators of gene expression involved in many biological processes including carcinogenesis. We determined miR-205 expression levels in tumor/non-tumor tissues of 45 esophageal cancer patients using qPCR and found that decreased level of miR-205 in tumor tissue […]
Heat shock protein 27 and gross cystic disease fluid protein 15 play critical roles in molecular apocrine breast cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Molecular apocrine breast cancer (MABC) has a distinct hormonal profile, being estrogen receptor (ER) and progesterone receptor (PR) negative but androgen receptor (AR) positive. The clinical significance of MABC and its relative variables have not been absolutely clarified and remain to be determined. Five hundred cases of invasive breast carcinoma were randomly selected in […]
Oncogenic relevant defensins: expression pattern and proliferation characteristics of human tumor cell lines
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The objective of this study was to investigate gene expression levels of oncogenic relevant human defensins and their impact on proliferation rates of 29 cell lines derived from main types of different tumor origins. Differential gene expression analysis of human defensins was performed by real-time PCR experiments. The proliferation rate of tumor cells that had […]
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου