The Effects of Language Dominance in the Perception and Production of the Galician Mid Vowel Contrasts
The Effects of Language Dominance in the Perception and Production of the Galician Mid Vowel Contrasts: Aims: This study investigates the perception and production of the Galician mid vowel contrasts by 54 early Spanish-Galician bilinguals in the cities of Vigo and Santiago (Galicia, Spain). Empirical data is provided to examine the role of language dominance in the perception and production of Galician mid vowel contrasts in order to determine whether the Galician vowel system is becoming more Spanish-like as a result of extensive contact with Spanish in urban areas. Methods: Perce... περισσότερα »
Spanish for the Audiologist: Is There an App for That?
Spanish for the Audiologist: Is There an App for That?: According to the U.S. Census Bureau, the number of people, 5 years of age and older speaking a language other than English at home has more than doubled within the last three decades. Spanish speakers are prominent in these numbers. Additionally, 41% report speaking English less than “very well.” We can surmise from this data that a significant number of patients/families seeking hearing health services from audiologists may have limited English proficiency or a language barrier. In contrast, according to ASHA demographics, the... περισσότερα »
Dynamic Assessment With Bilinguals: A Focus on Increasing Clinicians' Confidence
Dynamic Assessment With Bilinguals: A Focus on Increasing Clinicians' Confidence: Speech-language pathologists (SLPs) are obligated to judiciously select and administer appropriate assessments without inherent cultural or linguistic bias (Individuals with Disabilities Education Act [IDEA], 2004). Nevertheless, clinicians continue to struggle with appropriate assessment practices for bilingual children, and diagnostic decisions are too often based on standardized tests that were normed predominately on monolingual English speakers (Caesar & Kohler, 2007). Dynamic assessment is intend...περισσότερα »
Effect of Bilingualism on Multitasking: A Pilot Study
Effect of Bilingualism on Multitasking: A Pilot Study: Bilingual speakers rely on attentional and executive control to continuously inhibit or activate linguistic representations of competing languages, which leads to an increased efficiency known as “bilingual advantage”. Both monolingual and bilingual speakers were asked to perform multiple tasks of talking on a cell phone while simultaneously attending to simulated driving events. This study examined the effect of bilingualism on participants' performance during a dual-task experiment based on 20 monolingual and 13 bilingual heal... περισσότερα »
Haemophilus influenzae Type f Hijacks Vitronectin Using Protein H To Resist Host Innate Immunity and Adhere to Pulmonary Epithelial Cells
Haemophilus influenzae Type f Hijacks Vitronectin Using Protein H To Resist Host Innate Immunity and Adhere to Pulmonary Epithelial Cells [INFECTIOUS DISEASE AND HOST RESPONSE]: The incidence of invasive *Haemophilus influenzae* type b (Hib) disease has significantly decreased since the introduction of an efficient vaccine against Hib. However, in contrast to Hib, infections caused by *H. influenzae* serotype f (Hif) are emerging. We recently did a whole genome sequencing of an invasive Hif isolate, and reported that Hif interacts with factor H by expressing protein H (PH). In this... περισσότερα »
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus [IMMUNE SYSTEM DEVELOPMENT]: The forkhead box N1 (Foxn1) protein is the key regulator of thymic epithelial cell (TEC) development, yet how Foxn1 functions remains largely unknown. All mature TECs arise from Foxn1-expressing progenitors/immature TECs and it is widely assumed that TECs as a whole are defined by Foxn1 expression. However, data on the Foxn1 protein are virtually lacking. In this study, we developed novel tools to visualize Foxn1 protein expression at single-cell resolution. We generated Foxn1 kn... περισσότερα »
Palliative Reconstruction for the Management of Incurable Head and Neck Cancer
Palliative Reconstruction for the Management of Incurable Head and Neck Cancer: J reconstr Microsurg DOI: 10.1055/s-0035-1568156 Background Surgical management of head and neck cancer is resource intensive and physiologically demanding. In patients with incurable disease, although the indications for surgery are not well defined, palliative benefit can be significant. The goal of this investigation was to compare outcomes of patients who underwent resection and reconstruction of head and neck cancer with curative intent with those who underwent similar procedures with palliative i...περισσότερα »
Early Axonal Area Measurement Predicts Early Nerve Regeneration Outcomes
Early Axonal Area Measurement Predicts Early Nerve Regeneration Outcomes: J reconstr Microsurg DOI: 10.1055/s-0035-1568155 Background Study of peripheral nerve injury and regeneration in laboratory animals can be time consuming and expensive. This study determines if it is possible to reduce time and cost for a peripheral nerve regeneration study. Purpose The purpose of this study was to determine if nerve axonal area (NXA) or nerve fiber counting (NFC) correlates with compound muscle action potential (CMAP) recovery which is known to predict functional muscular recovery in the earl...περισσότερα »
Aspirin Inhibits LPS-Induced Expression of PI3K/Akt, ERK, NF-κB, CX3CL1, and MMPs in Human Bronchial Epithelial Cells
Aspirin Inhibits LPS-Induced Expression of PI3K/Akt, ERK, NF-κB, CX3CL1, and MMPs in Human Bronchial Epithelial Cells: AbstractThis study focused on the effects of aspirin on lipopolysaccharide (LPS)-induced expression of phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt), extracellular signal-regulated protein kinase (ERK), nuclear factor-κB (NF-κB), CX3CL1, and MMPs in human bronchial epithelial cells. Human bronchial epithelial cells were seeded in six-well plates. After 24 h, the cells were classified into six groups: control blank (CK) group; LPS group; PD98059 (ERK inhib...περισσότερα »
Uncoupling of Vascular Endothelial Growth Factor (VEGF) and Inducible Nitric Oxide Synthase (iNOS) in Gingival Tissue of Type 2 Diabetic Patients
Uncoupling of Vascular Endothelial Growth Factor (VEGF) and Inducible Nitric Oxide Synthase (iNOS) in Gingival Tissue of Type 2 Diabetic Patients: ABSTRACTIn this study, we investigate the relation between vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in periodontal disease of diabetic and non-diabetic individuals. We evaluated immunohistochemical VEGF and iNOS expressions in gingival biopsies from healthy individuals (no chronic periodontitis (CP)), patients with periodontitis alone (CP), patients with diabetes alone (DM) and diabetic patien...περισσότερα »
A rare complication of dental extraction: Life-threatening orofacial angioedema
A rare complication of dental extraction: Life-threatening orofacial angioedema: *Saurabh Kumar, Jagadish Ebenezer, Leni George, Pari Selvakumar* Indian Journal of Oral Sciences 2015 6(3):133-136 Dental extraction is considered to be one of the simplest minor surgical procedures. This procedure is rarely associated with any systemic complication. However serious complication can occur if adequate attention is not given to the patient's medical history. Here we report a case of orofacial angioedema following dental extraction. This case report uniquely emphasis on acquired orofac... περισσότερα »
The relationship of the inferior alveolar nerve canal with the roots of impacted mandibular third molars in a group of the South Indian population
The relationship of the inferior alveolar nerve canal with the roots of impacted mandibular third molars in a group of the South Indian population: *Sujata Mohan Byahatti* Indian Journal of Oral Sciences 2015 6(3):108-112 Aim/Objective: The aim of this study was to evaluate the topographic relationship between the inferior alveolar nerve canal (IANC) and the roots of impacted mandibular third molars. Materials and Methods: The study conducted at the Department of Oral Medicine and Radiology, Maratha Mandals NG Halgekar College of Dental Sciences and Research Center, Belgaum, Ka... περισσότερα »
Novel approach in the treatment of a persistent oroantral fistula using an acellular dermal graft tissue: technical note
Novel approach in the treatment of a persistent oroantral fistula using an acellular dermal graft tissue: technical note: Most oroantral fistulas are treated successfully with local operations such as buccal or palatal advancement flaps. Persistent morbidity from a chronic fistula is rare and can be difficult to manage.1 We report the simple, successful closure of a persistent oroantral fistula using an allogenic acellular dermal tissue matrix (AlloDerm®, LifeCellTM, Biohorizons Ltd, Birmingham, USA) in a application, which to our knowledge, has not previously been reported.
Anterior superior alveolar nerve (ASAN).
Anterior superior alveolar nerve (ASAN).: Related Articles*Anterior superior alveolar nerve (ASAN).* Swiss Dent J. 2015;125(11):1202-9 Authors: von Arx T, Lozanoff S Abstract The anterior superior alveolar nerve (ASAN) is a branch of the infraorbital nerve. Only few studies have morphometrically evaluated the course of the ASAN. Midfacial segments of ten hemisectioned fresh adult cadaver heads were dissected to uncover the anterior wall of the maxilla. Specimens were subsequently decalcified and the bone overlying the ASAN was removed under a microscope to expose the ASAN. Its br...περισσότερα »
Head and neck mucosal melanoma: clinicopathological analysis of 51 cases treated in a single cancer centre and review of the literature
Head and neck mucosal melanoma: clinicopathological analysis of 51 cases treated in a single cancer centre and review of the literature: Head and neck mucosal melanoma (HNMM) is a rare and aggressive malignancy. The objective of this study was to describe the outcomes of patients with HNMM. Clinical and pathological data from 51 patients with primary HNMM were reviewed. All patients were treated at a single cancer centre between 1954 and 2012. Most tumours involved the nasal cavity (35.3%) and upper gingiva (29.4%). The majority of lesions were ulcerated (54.9%) and pigmented (84.3%...περισσότερα »
A photographic study on Visagism
A photographic study on Visagism: *Anuradha Sharma, Reena Luthra, Palwinder Kaur* Indian Journal of Oral Sciences 2015 6(3):122-127 Background: Designing the smile based only on mechanical parameters such as shape and size of the face will give a monotonous and stereotype appearance whereas customizing it with the person's attitudes and behavior will make it more life-like. Aim: To find out as to whether the concept of Visagism is present in dentate individuals. Setting and Design: The dominant temperaments of 50 subjects were determined with a self-reporting questionnaire which...περισσότερα »
Extragnathic psammous desmo-osteoblastoma of maxilla - A unique entity
Extragnathic psammous desmo-osteoblastoma of maxilla - A unique entity: *Ashwant Kumar Vadepally, Ramen Sinha, Uday Kiran Uppada, Syed Afroz* Indian Journal of Oral Sciences 2015 6(3):140-144 Juvenile psammomatoid ossifying fibroma (JPOF) is a rare fibro-osseous neoplasm in young children which is locally aggressive, spreads quickly and has a very high recurrence rate. Early detection and complete excision are essential. It generally occurs in extragnathic craniofacial bones such as periorbital, frontal, and ethmoid bones. Jaw bones are rarely involved. Here, we report a case of...περισσότερα »
A rare complication of dental extraction: Life-threatening orofacial angioedema
A rare complication of dental extraction: Life-threatening orofacial angioedema: *Saurabh Kumar, Jagadish Ebenezer, Leni George, Pari Selvakumar* Indian Journal of Oral Sciences 2015 6(3):133-136 Dental extraction is considered to be one of the simplest minor surgical procedures. This procedure is rarely associated with any systemic complication. However serious complication can occur if adequate attention is not given to the patient's medical history. Here we report a case of orofacial angioedema following dental extraction. This case report uniquely emphasis on acquired orofac... περισσότερα »
Smile esthetics
Smile esthetics: *Deepika Janghu, Vinay S Dua, Rajat Mangla, Mannu Khanna* Indian Journal of Oral Sciences 2015 6(3):101-107 An attractive, well-balanced smile is a paramount treatment objective of modern orthodontic therapy. The establishment of good dental esthetics is the first step toward a pleasing smile that orthodontic patients expect from treatment. Extensive studies on facial features have resulted in the establishment of norms that orthodontists use as guidelines to evaluate facial forms and to direct therapy. The esthetics of a smile is influenced by many features suc...περισσότερα »
Mitochondrial pathology in progressive cerebellar ataxia
Mitochondrial pathology in progressive cerebellar ataxia: Abstract BackgroundMitochondrial disease can manifest as multi-organ disorder, often with neurological dysfunction. Cerebellar ataxia in isolation or in combination with other features can result from mitochondrial disease yet genetic testing using blood DNA is not sufficient to exclude this as a cause of ataxia. Muscle biopsy is a useful diagnostic tool for patients with ataxia suspected of mitochondrial disease. Our aim was to determine specific patient selection criteria for muscle biopsy to see how frequent mitochondria... περισσότερα »
FDA Approves Trabectedin to Treat Two Types of Soft Tissue Sarcoma
FDA Approves Trabectedin to Treat Two Types of Soft Tissue Sarcoma: On October 23, the Food and Drug Administration (FDA) approved trabectedin (Yondelis®) for the treatment of two subtypes of soft tissue sarcomas: liposarcoma and leiomyosarcoma. The approval is for patients whose cancers are advanced or cannot be removed by surgery and who have already been treated with anthracycline-based chemotherapy. The FDA based the approval on the results of a randomized clinical trial in which more than 500 patients with metastatic or recurrent liposarcoma or leiomyosarcoma were randomly ass... περισσότερα »
Bimodal stimulus timing-dependent plasticity in primary auditory cortex is altered after noise exposure with and without tinnitus
Bimodal stimulus timing-dependent plasticity in primary auditory cortex is altered after noise exposure with and without tinnitus: Central auditory circuits are influenced by the somatosensory system, a relationship that may underlie tinnitus generation. In the guinea pig dorsal cochlear nucleus (DCN), pairing spinal trigeminal nucleus (Sp5) stimulation with tones at specific intervals and orders facilitated or suppressed subsequent tone-evoked neural responses, reflecting spike timing-dependent plasticity (STDP). Furthermore, after noise-induced tinnitus, bimodal responses in DCN ... περισσότερα »
DNA Mismatch Repair in Cancer Research
Mouse Models of via ScienceDirect Publication: DNA Repair Publication date: Available online 4 December 2015 *Source:*DNA Repair Author(s): Kyeryoung Lee, Elena Tosti, Winfried Edelmann Germline mutations in DNA mismatch repair (MMR) genes are the cause of hereditary non-polyposis colorectal cancer/Lynch syndrome (HNPCC/LS) one of the most common cancer predisposition syndromes, and defects in MMR are also prevalent in sporadic colorectal cancers. In the past, the generation and analysis of mouse lines with knockout mutations in all of the known MMR genes has provided insight into how... περισσότερα »
Antimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract
In Vitro Antimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract: Background. The aim of the present study was to evaluate the antimicrobial effect of a white grape juice extract (WGJe) against a range of Gram-positive and Gram-negative bacteria, yeasts, and the fungus Aspergillus niger. WGJe was also tested on the production of bacterial biofilms in vitro. Results. WGJe inhibited in vitro most Gram-positive bacteria tested, Staphylococcus aureus ATCC 6538P being the most sensitive strain (MIC values of 3.9 μg/mL). The effect was bacte... περισσότερα »
Clinico-epidemiological study of oral squamous cell carcinoma
: A tertiary care centre study in North India via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 4 December 2015 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Mahendra Pratap Singh, Vijay Kumar, Akash Agarwal, Rajendra Kumar, M.L.B. Bhatt, Sanjeev Misra IntroductionOral squamous cell carcinoma (OSCC) ranks 12th most common cancer in the world.ObjectiveThe aim of this study was to retrospectively evaluate the OSCC.MethodsA retrospective study of 611 OSCC patients from January 2010 to December 2013 w... περισσότερα »
Fat grafting for the prevention of pressure ulcers
Fat grafting for the prevention of pressure ulcers: a case series: Abstract BackgroundPressure sores tend to recur and become chronic, especially in high-risk groups such as paraplegics, who may present multiple wounds and have long life expectancies. Here, we assess the outcomes achieved with fat grafting as a new preventive strategy for pressure sores. MethodsFrom 2010 to 2013, seven paraplegic patients presenting stage I or stage II pressure ulcers were treated with the injection of 115 to 620 cm3 of fat that was previously filtered and washed with saline solution. Patients ... περισσότερα »
Polyomavirus positive and negative merkel cell carcinomas
Hotspot mutations in via http://rss.sciencedirect.com/publication/science/22107762 Publication date: Available online 4 December 2015 *Source:*Cancer Genetics Author(s): Tuukka Veija, Virinder Kaur Sarhadi, Virve Koljonen, Tom Bohling, Sakari Knuutila Merkel cell polyomavirus (MCV) infection underlies most Merkel cell carcinoma (MCC), a primary neuroendocrine carcinoma of the skin. While previous research has focused on MCV-positive MCC tumors, less is known about the oncogenesis in MCV-negative tumors.In this study, we analyzed mutational status of 27 MCC tumors with known MCV status... περισσότερα »
Long term results of postoperative Intensity-Modulated Radiation Therapy (IMRT) in the treatment of Squamous Cell Carcinoma (SCC) located in the oropharynx or oral cavity
Long term results of postoperative Intensity-Modulated Radiation Therapy (IMRT) in the treatment of Squamous Cell Carcinoma (SCC) located in the oropharynx or oral cavity: To report our long-term results with postoperative intensity-modulated radiation therapy (IMRT) in patients suffering from squamous-cell carcinoma (SCC) of the oral cavity or oropharynx. Abstract Background To report our long-term results with postoperative intensity-modulated radiation therapy (IMRT) in patients suffering from squamous-cell carcinoma (SCC) of the oral cavity or oropharynx. Methods Seventy five...περισσότερα »
Growth patterns of craniopharyngiomas
Growth patterns of craniopharyngiomas: clinical analysis of 226 patients: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECT Craniopharyngiomas (CPs) are rare epithelial tumors that are often associated with an enigmatic and unpredictable growth pattern. Understanding the growth patterns of these tumors has a direct impact on surgical planning and may enhance the safety of radical tumor removal. The aim of this study was to analyze the growth patterns and surgical treatment of CPs with a focus on the involvement of the hypothalamopituitary axis and the relationship of the ... περισσότερα »
Current scenario of biomarkers in head and neck cancer
Current scenario of biomarkers in head and neck cancer: *Parul A Jhamb, Aakarsh V Jhamb, Rina Shah, Aparna Dave, Manpreet Kalra, Renu Tanwar* Indian Journal of Oral Sciences 2015 6(3):93-100 The diagnosis and management of tumors commences with histopathology using routine staining procedures followed by immunohistochemical techniques in which certain biochemical indicators -the tumor markers are utilized. Each subcellular component can produce markers in the form of glycoproteins, antigens, receptors, hormones, enzymes, proteomic elements and genomic factors. The ongoing resear...περισσότερα »
Prosthetic rehabilitation of acquired maxillary defect
Prosthetic rehabilitation of acquired maxillary defect: *Gowri Sivaramakrishnan* Indian Journal of Oral Sciences 2015 6(3):145-149 This case report describes the rehabilitation of a patient with acquired maxillary defect using heat polymerizing acrylic resin hollow bulb obturator. The aim of the prosthesis is to improve the retention of the prosthesis and the esthetics. Acquired maxillary defects caused by surgical correction of tumors or trauma can lead to various functional, esthetic and psychologic disturbances to the patient. The defect results in liquid and food escaping i... περισσότερα »
Vocabulary Skills of Spanish-English Speaking Elementary Students: A Pilot Study
Vocabulary Skills of Spanish-English Speaking Elementary Students: A Pilot Study: Introduction Bilingualism is the norm worldwide. Despite the fact that nearly one in five individuals (17.9%; U.S. Census Bureau, 2007) speaks another language other than English in the home, knowledge regarding the nature of bilingualism and school performance, particularly vocabulary skills in bilingual children, is still needed. Purpose This study investigated vocabulary skills of bilingual, Spanish-English speaking students enrolled in 3rd, 4th, and 5th grades. Methods Fifteen Spanish-English s... περισσότερα »
Adjuvant hypofractionated partial-brain radiation therapy for pediatric brain metastases
Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report: Journal of Neurosurgery: Pediatrics, Ahead of Print. This case report demonstrates that hypofractionated partial-brain radiation therapy with limited margins is a reasonable approach following gross tumor resection of Ewing sarcoma metastases to the brain. The patient presented with 2 intracranial metastases treated with gross-total resection followed by radiation therapy to 30 Gy in 5 fractions. The patient experienced symptomatic treatment-related inflammatory chan... περισσότερα »
Erythema migrans associated with partial Horner's syndrome
Lyme disease is a tick-borne illness caused mainly by three species of spirochaete *Borrelia*—*B. burgdorferi*, *B. afzelii* and *B. garinii*. It has three stages of presentation—early localised, early-disseminated and late Lyme. Erythema migrans is the most common manifestation of Lyme disease, and is usually seen 7–14 days after the tick bite. Patients seldom remember the tick bite. Patients may often present with neurological manifestations indicating neuroborreliosis. These manifestations range from a simple nerve palsy to severe complications such as papilloedema, myelitis or... περισσότερα »
Intravenous leiomyomatosis with intracardiac extension: an unusual presentation of uterine leiomyoma and evaluation with 256-slice dual-source multidetector CT and cardiac MRI
We report a case of a 40-year-old woman who presented with breathlessness, palpitations and vague pelvic pain for 6 months. The dyspnoea was non-exertional and episodic. She was a non-diabetic, non-hypertensive and had no history of prior surgeries. ECG and chest radiograph were normal. Cardiac MRI and 256-slice dual-source multidetector CT evaluation revealed the presence of a uterine and left adnexal mass with intravenous extension into the inferior vena cava via the gonadal veins, and further cephalad extension into the right atrium and ventricle. The patient was referred to th...περισσότερα »
Epidermal inclusion cyst in a male breast: parallel linear echoes (tram-track appearance) on sonography as a diagnostic clue
Description A 25-year-old man presented with a painless swelling in his left breast for 2 years. On palpation, the mass was soft and mobile. Mammography showed a high-density, circumscribed mass in the central breast (figure 1). Ultrasound showed a mass with multiple clusters of parallel alternating echogenic and hypoechoic lines resembling tram-tracks (figure 2). Colour Doppler did not reveal any flow. Biopsy yielded white flaky material. Pathology revealed this to be keratin flakes suggestive of an Epidermal Inclusion Cyst (figure 3). Figure 1 Digital mammogram craniocaudal (... περισσότερα »
Drug-induced elastosis perforans serpiginosa
Description A 42-year-old woman presented with a 5-year history of multiple enlarging skin lesions. Her medical history was significant for Wilson's disease, for which she had taken penicillamine for approximately 20 years. She had multiple small erythaematous keratotic papules grouped in both a circular and arciform pattern. These lesions were present on her neck, in her axillary skin folds, antecubital fossa and groin. She had associated skin laxity (figures 1 and 2). Figure 1 Keratotic papules, axillary fold. Figure 2 Skin laxity and keratotic papules grouped in serpiginous... περισσότερα »
Hemodynamic and morphological characteristics of unruptured posterior communicating artery aneurysms with oculomotor nerve palsy
Hemodynamic and morphological characteristics of unruptured posterior communicating artery aneurysms with oculomotor nerve palsy: Journal of Neurosurgery, Ahead of Print. OBJECT Unruptured posterior communicating artery (PCoA) aneurysms with oculomotor nerve palsy (ONP) have a very high risk of rupture. This study investigated the hemodynamic and morphological characteristics of intracranial aneurysms with high rupture risk by analyzing PCoA aneurysms with ONP. METHODS Fourteen unruptured PCoA aneurysms with ONP, 33 ruptured PCoA aneurysms, and 21 asymptomatic unruptured PCoA aneur... περισσότερα »
Tumors of the peripheral nervous system: Benign peripheral nerve sheath tumors (BPNSTs), malignant peripheral nerve sheath tumors (MPNSTs), and peripheral non–neural sheath tumors (PNNSTs)
Tumors of the peripheral nervous system: analysis of prognostic factors in a series with long-term follow-up and review of the literature: Journal of Neurosurgery, Ahead of Print. OBJECT Only a few published studies of the surgical treatment of benign peripheral nerve sheath tumors (BPNSTs), malignant peripheral nerve sheath tumors (MPNSTs), and peripheral non–neural sheath tumors (PNNSTs) have analyzed the results and possible prognostic factors using multivariate analysis. The authors report on their surgical series of cases of BPNSTs, MPNSTs, and PNNSTs with long-term follow-up ... περισσότερα »
Prospective, multidisciplinary recording of perioperative errors in cerebrovascular surgery: is error in the eye of the beholder?
Prospective, multidisciplinary recording of perioperative errors in cerebrovascular surgery: is error in the eye of the beholder?: Journal of Neurosurgery, Ahead of Print. OBJECT Surgery requires careful coordination of multiple team members, each playing a vital role in mitigating errors. Previous studies have focused on eliciting errors from only the attending surgeon, likely missing events observed by other team members. METHODS Surveys were administered to the attending surgeon, resident surgeon, anesthesiologist, and nursing staff immediately following each of 31 cerebrovascul... περισσότερα »
Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study
Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study: Journal of Neurosurgery, Ahead of Print. OBJECT Current recommendations stress the need for cognitive parameters to be integrated in the evaluation of outcomes for intracranial meningioma surgery. The aim of this prospective study was to examine neurocognitive function in meningioma patients pre- and postoperatively. METHODS Patients with skull base (anterior and middle fossa) and convexity (anterior and posterior) meningiomas (n = 54) underwent neuropsychological...περισσότερα »
Growth hormone–secreting macroadenoma of the pituitary gland successfully treated with the radiolabeled somatostatin analog 90Y-DOTATATE: case report
Growth hormone–secreting macroadenoma of the pituitary gland successfully treated with the radiolabeled somatostatin analog 90Y-DOTATATE: case report: Journal of Neurosurgery, Ahead of Print. Pituitary tumors causing acromegaly are usually macroadenomas at the time of diagnosis, and they can grow aggressively, infiltrating surrounding tissues. Difficulty in achieving complete tumor removal at surgery can lead toward a strong tendency for recurrence, making it necessary to consider a means of treatment other than those currently used such as somatostatin analogs (SSAs), growth hormo...περισσότερα »
Chemical-induced skin tumor promotion
Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion: Background: Drastic increment of skin cancer incidence has driven natural product-based chemoprevention as a promising approach in anticancer drug development. Apart from its traditional usages against various ailments, Ardisia crispa (Family: Myrsinaceae) specifically its triterpene-quinone fraction (TQF) which was isolated from the root hexane extract (ACRH) was recently reported to exert antitumor promoting activity in vitro. This study aimed at determining chemopre... περισσότερα »
Assessment of initiation of post-exposure prophylaxis with anti-rabies vaccine in cases of dog bites: an observational study
Assessment of initiation of post-exposure prophylaxis with anti-rabies vaccine in cases of dog bites: an observational study: 2015-12-05T10-16-39Z *Source:* International Journal of Basic & Clinical Pharmacology Jaiprakash B. Ramanand, Swapnil Chudaman Jaykare, Sunita J. Ramanand, Ajitkumar M. Zende, Rama R. Bhosale, Jyoti R. Patil. Background: The management of rabies is challenging because of the long incubation period, lack of specificity of early prodromal symptoms and 100% fatality rate. Post-exposure prophylaxis (PEP) with anti-rabies vaccine (ARV) at the earliest has proven ...περισσότερα »
TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways
TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways: [image: sfx_links?getImage] Background: Long pentraxin 3 (PTX3) is a novel candidate marker for inflammation in many chronic diseases. As a soluble pattern recognition receptor, PTX3 is involved in amplification of inflammatory reactions and regulation of innate immunity. Previously, we demonstrate that human airway smooth muscle cells (HASMC) express constitutively PTX3 and upon TNF stimulation. However, very little is known about the mechanism governing its expression in ... περισσότερα »
Drug-induced elastosis perforans serpiginosa
Drug-induced elastosis perforans serpiginosa: Description A 42-year-old woman presented with a 5-year history of multiple enlarging skin lesions. Her medical history was significant for Wilson's disease, for which she had taken penicillamine for approximately 20 years. She had multiple small erythaematous keratotic papules grouped in both a circular and arciform pattern. These lesions were present on her neck, in her axillary skin folds, antecubital fossa and groin. She had associated skin laxity (figures 1 and 2). Figure 1 Keratotic papules, axillary fold. Figure 2 Skin laxity a... περισσότερα »
Erythema migrans associated with partial Horner's syndrome
Erythema migrans associated with partial Horner's syndrome: Lyme disease is a tick-borne illness caused mainly by three species of spirochaete *Borrelia*—*B. burgdorferi*, *B. afzelii* and *B. garinii*. It has three stages of presentation—early localised, early-disseminated and late Lyme. Erythema migrans is the most common manifestation of Lyme disease, and is usually seen 7–14 days after the tick bite. Patients seldom remember the tick bite. Patients may often present with neurological manifestations indicating neuroborreliosis. These manifestations range from a simple nerve pals... περισσότερα »
MRSA osteomyelitis with haematogenous spread to the pericardium
From bone to heart: a case of MRSA osteomyelitis with haematogenous spread to the pericardium: We report a case of a 55-year-old woman with a history of type 2 diabetes mellitus, Charcot arthropathy and end-stage renal disease, who presented with a syncopal episode after undergoing haemodialysis. She had a history of methicillin-resistant *Staphylococcus aureus* (MRSA) bacteraemia from an unknown source 3 months earlier, which was treated with an 8-week course of intravenous antibiotics. At the time of presentation to the emergency room, she was found to be in refractory shock. Bed... περισσότερα »
Antenatal diagnosis of aneurysmal malformation of the vein of Galen
Antenatal diagnosis of aneurysmal malformation of the vein of Galen: Vein of Galen malformation (VGAM) results from an aneurysmal aberration with an arteriovenous shunting of blood. Vein of Galen aneurysmal malformations are the most frequent arteriovenous malformations in infants and fetuses. The congenital malformation develops during weeks 6–11 of fetal development. Infants often die from high-output congestive heart failure. Vein of Galen aneurysmal malformations From Wikipedia, the free encyclopedia Axial image from computerized tomography angiogram showing arteriovenous c... περισσότερα »
Obstruction of the external auditory meatus secondary to a giant pyogenic granuloma
Obstruction of the external auditory meatus secondary to a giant pyogenic granuloma: Pyogenic granuloma is a benign lesion of the skin and mucosa commonly known to occur in the head and neck region. The current literature has not yet identified its occurrence within the conchal bowl, a condition that leads to obstruction of the external auditory meatus. We present the case of a 28-year-old man who presented with a history of 3–4 weeks of a rapidly enlarging pedunculated lesion within the conchal bowl of the right ear and conductive hearing loss. Initial management included excision... περισσότερα »
Visual Feedback of Tongue Movement for Novel Speech Sound Learning.
Visual Feedback of Tongue Movement for Novel Speech Sound Learning.: *Visual Feedback of Tongue Movement for Novel Speech Sound Learning.* Front Hum Neurosci. 2015;9:612 Authors: Katz WF, Mehta S Abstract Pronunciation training studies have yielded important information concerning the processing of audiovisual (AV) information. Second language (L2) learners show increased reliance on bottom-up, multimodal input for speech perception (compared to monolingual individuals). However, little is known about the role of viewing one's own speech articulation processes during speech train...περισσότερα »
Increases in Perspective Embedding Increase Reading Time Even with Typical Text Presentation: Implications for the Reading of Literature.
Increases in Perspective Embedding Increase Reading Time Even with Typical Text Presentation: Implications for the Reading of Literature.: *Increases in Perspective Embedding Increase Reading Time Even with Typical Text Presentation: Implications for the Reading of Literature.* Front Psychol. 2015;6:1778 Authors: Whalen DH, Zunshine L, Holquist M Abstract Reading fiction is a major component of intellectual life, yet it has proven difficult to study experimentally. One aspect of literature that has recently come to light is perspective embedding ("she thought I left" embedding he...περισσότερα »
Syllable Structure Universals and Native Language Interference in Second Language Perception and Production: Positional Asymmetry and Perceptual Links to Accentedness.
Syllable Structure Universals and Native Language Interference in Second Language Perception and Production: Positional Asymmetry and Perceptual Links to Accentedness.: *Syllable Structure Universals and Native Language Interference in Second Language Perception and Production: Positional Asymmetry and Perceptual Links to Accentedness.* Front Psychol. 2015;6:1801 Authors: Cheng B, Zhang Y Abstract The present study investigated how syllable structure differences between the first Language (L1) and the second language (L2) affect L2 consonant perception and production at syllable... περισσότερα »
Clinics in Plastic Surgery,Chin Advancement, Augmentation, and Reduction as Adjuncts to Rhinoplasty,Cleft Lip Nose,The Cleft Lip Nose: Primary and Secondary Treatment,Costal Cartilage Grafts in Rhinoplasty,Harvesting Rib Cartilage in Primary and Secondary Rhinoplasty,Pyriform Aperture Augmentation as An Adjunct to Rhinoplasty,Revision Rhinoplasty,The Short Nose,Projection and Deprojection Techniques in Rhinoplasty,Nasal Tip Deficiency,Alar Rim Deformities,Reshaping of the Broad and Bulbous Nasal Tip,The Crooked Nose,Surgical Treatment of the Twisted Nose,Surgical Treatment of the Middle Nasal Vault,Nasal Bone Osteotomies,Management of the Nasal Dorsum: Construction and Maintenance of a Barrel Vault,Dorsal Hump Reduction and Osteotomies,Surgical Management of Nasal Airway Obstruction,Surface Aesthetics and Analysis,Open and Closed Rhinoplasty,Surgical Treatment of Nasal Obstruction in Rhinoplasty,Rhinoplasty in Latino Patients,Rhinoplasty in the African American Patient: Anatomic Considerations and Technical Pearls,
Rhinoplasty: A Multispecialty Approach Publication date: January 2016 Source:Clinics in Plastic Surgery, Volume 43, Issue 1 Author(s): Babak Azizzadeh Copyright Publication date: January 2016 Source:Clinics in Plastic Surgery, Volume 43, Issue 1 Contributors Publication date: January 2016 Source:Clinics in Plastic Surgery, Volume 43, Issue 1 Contents Publication date: January 2016 Source:Clinics in Plastic Surgery, Volume 43, Issue 1 Forthcoming Issues Publication date: January 2016 Source:Clinics in Plastic Surgery, Volume 43, Issue 1 Rhinoplasty: Educatio... περισσότερα »
Paralinguistic abilities of adults with intellectual disability
Paralinguistic abilities of adults with intellectual disability via ScienceDirect Publication: Research in Developmental Disabilities Publication date: January 2016 *Source:*Research in Developmental Disabilities, Volume 48 Author(s): Mirjana Đorđević, Nenad Glumbić, Branislav Brojčin The aim of this research was to determine the ability level of paralinguistic production and comprehension in adults with intellectual disability (ID) with regard to the level of their intellectual functioning and presence of co-morbid psychiatric conditions or dual diagnosis (DD).The sample consisted of 1... περισσότερα »
Lymphoma Presenting as Acute-Onset Dysphagia.
Lymphoma Presenting as Acute-Onset Dysphagia.: *Lymphoma Presenting as Acute-Onset Dysphagia.* Case Rep Neurol Med. 2015;2015:745121 Authors: Simmons DB, Bursaw AW Abstract A 61-year-old man with recent Bell's palsy developed acute vocal cord paralysis causing severe dysphagia. CSF analysis showed elevated protein and a normal cell count; contrast-enhanced MRI of the brain was normal. He was treated with IVIG for a presumed bulbar-variant AIDP and gradually improved. Six months later, the patient developed rapidly progressive hearing loss and vestibular dysfunction. Repeat MRI re... περισσότερα »
Retinoic Acid Signaling: A New Piece in the Spoken Language Puzzle.
Retinoic Acid Signaling: A New Piece in the Spoken Language Puzzle.: *Retinoic Acid Signaling: A New Piece in the Spoken Language Puzzle.* Front Psychol. 2015;6:1816 Authors: van Rhijn JR, Vernes SC Abstract Speech requires precise motor control and rapid sequencing of highly complex vocal musculature. Despite its complexity, most people produce spoken language effortlessly. This is due to activity in distributed neuronal circuitry including cortico-striato-thalamic loops that control speech-motor output. Understanding the neuro-genetic mechanisms involved in the correct developm...περισσότερα »
Editorial Board/Aims and Scope
Publication date: 10 December 2015 *Source:*Vaccine, Volume 33, Issue 50 from #Medicine via ola Kala on Inoreader http://ift.tt/1XOXj4D via IFTTT
A Brazilian report using serological and molecular diagnosis to monitoring acute ocular toxoplasmosis
Background: Toxoplasmosis was recently included as a neglected disease by the Center for Disease Control. Ocular toxoplasmosis is one clinical presentation of congenital or acquired infection. The laboratory diagnosis is being used worldwide to support the clinical diagnosis and imaging. The aim of this study was to evaluate the use of serology and molecular methods to monitor acute OT in immunocompetent patients during treatment. Methods: Five immunocompetent patients were clinically diagnosed with acute OT. The clinical evaluation was performed by ophthalmologic examination using... περισσότερα »
Emotion socialization practices in Italian and Hong Kong-Chinese mothers
Background: Parents' emotion socialization practices are their ways of handling their children's emotional experiences in light of cultural expectations surrounding emotions. Such practices are thought to significantly affect children's social adjustment. We compared the parenting practices of Italian and Hong Kong Chinese samples in an ethnological validation study of the maternal responses to children's emotion scale (MRCES). Participants were 71 Italian mothers (M = 39.45) and 71 Hong Kong-Chinese mothers (M = 37.75) with children aged 6–9 years.FindingsThe results confirmed th... περισσότερα »
The Role of Toll-Like Receptors and Myeloid Differentiation Factor 88 in Bjerkandera adusta-Induced Lung Inflammation
*Background:* Recently, a cluster of patients with an intractable allergic fungal cough who were characterized by sensitization to *Bjerkandera adusta* was reported. In the present study, the role of Toll-like receptors and myeloid differentiation factor 88 (MyD88) in *B. adusta-*induced lung inflammation was investigated. *Methods:* Wild-type (WT), *TLR2*-/-*,**TLR4* -/-*,* and *MyD88*-/- BALB/c mice were intratracheally challenged with *B. adusta* 4 times at 2-week intervals. Lung pathology, bronchoalveolar lavage fluid (BALF) cytological profiles, and inflammatory mediators in BALF...περισσότερα »
Protective effects of exercise in metabolic disorders are mediated by inhibition of mitochondrial-derived sterile inflammation
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Maghsoud Peeri, Shayan Amiri While beneficial properties of physical activity and exercise on human health have been extensively reported in literature, the exact mechanism(s) underpinning impacts of exercise are not well understood. Focusing on metabolic disorders, as the main causes of social and economic burden in current century, exercise exhibited promising effects in prevention, alleviation and retardation of these disorders including, type 2 diabetes (T2D), Alzheimer's disease (AD), maj...περισσότερα »
Identification of the specific epigenetic alterations associated with chemo-resistance via reprogramming of cancer cells
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Jong Joo Kim, Rajani Rai BackgroundChemo-resistance is the main obstacle in cancer therapy, limiting the effectiveness of drug treatment. Epigenetics-mediated changes are suggested as a critical factor paying the chemo-resistance phenotype. Since epigenetic modulations are a reversible phenomenon, reversion of epigenetic changes represents a promising therapeutic approach for cancer. However, heterogeneity in epigenetic marks in tumor cells makes it difficult to identify the specific epigeneti...περισσότερα »
“Cystic fibrotics could survive cholera, choleraics could survive cystic fibrosis”; hypothesis that explores new horizons in treatment of cystic fibrosis
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Arsalan Azimi Cystic fibrosis, the most common inherited disease of white population, is a disease of CFTR channels, in which mucosal function of many organs especially respiratory tract is impaired. Decreased mucociliary clearance and accumulation of mucus in airways facilitates colonization of infectious microorganisms, followed by infection. Following chronic infection, persistent inflammation ensues, which results in airway remodeling and deterioration of mucociliary clearance and result i...περισσότερα »
A suggestion about the cause of inflammation in acute atherosis complicating poor placentation in preeclampsia
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Arnold E. Eggers The hypothesis is set forth that maternal release of epinephrine in the adrenal medulla causes systemic platelet activation (SPA) which, in turn, initiates coagulation via the intrinsic pathway and leads to thrombin generation. Thrombin causes inflammation, which is the underlying cause of acute atherosis in preeclampsia (PE). Each step of this cascade is examined in detail and supporting literature documented. SPA is associated with migraine headaches, which are a prominent c... περισσότερα »
A hypothesis about how to achieve anticoagulation without bleeding
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Arnold E. Eggers The hypothesis is set forth that a prothrombotic state is frequently caused by epinephrine-activated platelets initiating the intrinsic coagulation cascade by binding factor XII, a pathway which is enhanced by stasis. This pathway explains spontaneous non-injury related thrombosis in atrial fibrillation on the arterial side of the circulation and deep vein thrombosis/pulmonary embolism on the venous side of the circulation. Pharmacological interventions directed against target... περισσότερα »
Title page/Editorial Board
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 from #Medicine via ola Kala on Inoreader http://ift.tt/1OPynm8 via IFTTT
Possible scenarios of the influence of low-dose ionizing radiation on neural functioning
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Vladimir E. Zakhvataev Possible scenarios of the influence of ionizing radiation on neural functioning and the CNS are suggested. We argue that the radiation-induced bystander mechanisms associated with Ca2+ flows, reactive nitrogen and oxygen species, and cytokines might lead to modulation of certain neuronal signaling pathways. The considered scenarios of conjugation of the bystander signaling and the neuronal signaling might result in modulation of certain synaptic receptors, neurogenesis, ... περισσότερα »
Adiponutrin (PNPLA3) in liver fibrogenesis: Is unaltered HepG2 cell line a better model system compared to murine models?
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Atanu Kumar Dutta Alcoholic liver disease is a major source of morbidity and mortality worldwide. Twin studies had demonstrated heritability of alcoholic liver disease. Although to date only Adiponutrin (PNPLA3) rs738409 polymorphism (I148M) had been unequivocally proved to be associated with increased risk of alcoholic liver disease across different ethnicities. This protein was previously thought to have a predominant lipolytic role. However, recent investigations have provided evidence of l... περισσότερα »
Effect of protein arginine methyltransferase-1 inhibition on hypoxia-induced vasoconstriction
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Chellan Kumarasamy, Gurpreet Singh, Pachaiappan Raman, Kanchana Mala Hypoxia is defined as a decrease in the oxygen supply to a level below physiological levels which is insufficient to maintain cellular function, in the presence of unrestricted coronary inflow. It is one of the leading causes of global mortality and morbidity, due to its association with the pathology of cancer, cardiovascular disease and stroke. The common feature in these pathologies is the limitation of oxygen availability...περισσότερα »
The transcription, translation, transport-trail and autoimmunity: Guilt by association
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Clement E. Tagoe The autoimmune connective tissue diseases (ACTD) are a group of diseases which share clinical features and genetic inheritance. They are characterized by systemic autoimmunity and autoantibody production with a striking predilection for cellular components involved in transcription, translation and cellular transport. Although multiple triggers of autoimmunity have been proposed for this group of diseases including microbial agents such as viruses and bacteria, drugs, ultravio...περισσότερα »
Size of quadriceps femoris may contribute to thyrotoxic periodic paralysis
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Zi-Wei Tang, Ying He, Yu Yao, Li Qiu, Hao-Ming Tian Thyrotoxic periodic paralysis (TPP) frequently occurs on male individuals at their third and forth decades. The major site of involvement is the proximal muscles of lower limbs. Increasing evidence has shown that the occurrence of TPP is determined by multiple factors. We hypothesized that apart from hormonal fluctuations, skeletal muscle itself may explain for the age and sex variance as well. Our study was established to explore whether the...περισσότερα »
Genotype-phenotype correlation of 16p13.3 terminal duplication and 22q13.33 deletion: Natural history of a patient and review of the literature
This article reports a patient with a de novo ∼9.32 Mb duplication at 16p13.3 and a ∼71 Kb deletion at 22q13.33. The patient was followed from 1 month old to 3 years and 8 months of age and presented typical features of the 16p13.3 duplication syndrome. In addition, the patient presents a portal cavernoma, an alteration rarely reported in this condition. Renal agenesis was detected as additional developmental defect. After genomic array and FISH analysis, the karyotype was 46,XX,ins(22;16)(q13;p13.2p13.3). ish ins(22;16)(RP11-35P16+, RP11-27M24+). arr16p13.2p13.3(85,880-9,413,353...περισσότερα »
Mechanical force in regulating regeneration of the vascularized fat flap
Possible role of mechanical force in regulating regeneration of the vascularized fat flap inside a tissue engineering chamber via ScienceDirect Publication: Medical Hypotheses Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Yuan Ye, Yi Yuan, Feng Lu, Jianhua Gao In plastic and reconstructive surgery, adipose tissue is widely used as effective filler for tissue defects. Strategies for treating soft tissue deficiency, which include free adipose tissue grafts, use of hyaluronic acid, collagen injections, and implantation of synthetic materials, ha... περισσότερα »
Non-pharmacological treatment for neuropathic pain in children
Non-pharmacological treatment for neuropathic pain in children with cancer via ScienceDirect Publication: Medical Hypotheses Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): C. Casanova-García, S. Lerma Lara, M. Pérez Ruiz, D. Ruano Domínguez, E. Santana Sosa Neuropathic pain (NP) associated with childhood cancer is currently a difficult problem to control. It is treated with drugs that not only fail to provide the expected improvements, but which also have side effects. Therefore, the main aim of this pilot study is to assess whether non-pharm... περισσότερα »
Myalgic encephalomyelitis, chronic fatigue syndrome
: An infectious disease via ScienceDirect Publication: Medical Hypotheses Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): R.A. Underhill The etiology of myalgic encephalomyelitis also known as chronic fatigue syndrome or ME/CFS has not been established. Controversies exist over whether it is an organic disease or a psychological disorder and even the existence of ME/CFS as a disease entity is sometimes denied. Suggested causal hypotheses have included psychosomatic disorders, infectious agents, immune dysfunctions, autoimmunity, metabolic dist... περισσότερα »
Thyrotoxic periodic paralysis
Size of quadriceps femoris may contribute to via ScienceDirect Publication: Medical Hypotheses Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Zi-Wei Tang, Ying He, Yu Yao, Li Qiu, Hao-Ming Tian Thyrotoxic periodic paralysis (TPP) frequently occurs on male individuals at their third and forth decades. The major site of involvement is the proximal muscles of lower limbs. Increasing evidence has shown that the occurrence of TPP is determined by multiple factors. We hypothesized that apart from hormonal fluctuations, skeletal muscle itself may ex...περισσότερα »
Hypoxia-induced vasoconstriction
Effect of protein arginine methyltransferase-1 inhibition on via ScienceDirect Publication: Medical Hypotheses Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Chellan Kumarasamy, Gurpreet Singh, Pachaiappan Raman, Kanchana Mala Hypoxia is defined as a decrease in the oxygen supply to a level below physiological levels which is insufficient to maintain cellular function, in the presence of unrestricted coronary inflow. It is one of the leading causes of global mortality and morbidity, due to its association with the pathology of cancer, cardio... περισσότερα »
The influence of low-dose ionizing radiation on neural functioning
Possible scenarios of via ScienceDirect Publication: Medical Hypotheses Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Vladimir E. Zakhvataev Possible scenarios of the influence of ionizing radiation on neural functioning and the CNS are suggested. We argue that the radiation-induced bystander mechanisms associated with Ca2+ flows, reactive nitrogen and oxygen species, and cytokines might lead to modulation of certain neuronal signaling pathways. The considered scenarios of conjugation of the bystander signaling and the neuronal signaling mi... περισσότερα »
2015 Guidance on cancer immunotherapy development in early-phase clinical studies
2015 Guidance on cancer immunotherapy development in early-phase clinical studies: The development of cancer immunotherapies is progressing rapidly with a variety of technological approaches. They consist of “cancer vaccines”, which are based on the idea of vaccination, “effector cell therapy”, classified as passive immunotherapy, and “inhibition of immunosuppression”, which intends to break immunological tolerance to autoantigens or immunosuppressive environments characterizing antitumor immune responses. Recent reports showing clinical evidence of efficacy of immune checkpoint i...περισσότερα »
How to achieve anticoagulation without bleeding
A hypothesis about via ScienceDirect Publication: Medical Hypotheses Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Arnold E. Eggers The hypothesis is set forth that a prothrombotic state is frequently caused by epinephrine-activated platelets initiating the intrinsic coagulation cascade by binding factor XII, a pathway which is enhanced by stasis. This pathway explains spontaneous non-injury related thrombosis in atrial fibrillation on the arterial side of the circulation and deep vein thrombosis/pulmonary embolism on the venous side of the...περισσότερα »
Diet-induced phenotypic plasticity in head morphology
Diet-induced phenotypic plasticity in head morphology in European eel elvers (Anguilla anguilla): the effects of hard vs soft food: By bone remodeling and changing of muscle volume, fish can adapt to changes in mechanical loads they are confronted with, including dietary changes such as prey hardness. This capability of a genotype to develop different phenotypes in response to varying environment is known as phenotypic plasticity. Differences in prey type being consumed might trigger such a phenotypic plasticity in fish. In European eel, two morphotypes exist: broadheads and narrowh...περισσότερα »
Hard versus soft food: diet-induced phenotypic plasticity in head morphology in European elvers
Hard versus soft food: diet-induced phenotypic plasticity in head morphology in European elvers: By bone remodeling and changing of muscle volume, fish can adapt to changes in mechanical loads they are confronted with, including dietary changes such as prey hardness. This capability of a genotype to develop different phenotypes in response to varying environment is known as phenotypic plasticity. It has been shown that differences in prey type being consumed, triggers such a phenotypic plasticity in fish. Also in the European eel (Anguilla anguilla), two morphotypes exist: broadhead...περισσότερα »
Pseudo-anévrisme spontané intra-parotidien de l’artère carotide externe,Douleurs abdominales après sonde de gastrostomie percutanée révélatrices de métastases hépatiques,La septoplastie endoscopique,État de l’art du traitement endoscopique des brèches ostéoméningées du sinus frontal,Perception, production et intelligibilité de la parole de l’enfant francophone sourd profond implanté cochléaire précoce après infection congénitale par le cytomégalovirus,Trachéotomie chez l’enfant,Internat d’otorhinolaryngologie,Apport de la tomodensitométrie en 4 coupes au diagnostic de rhinosinusite chronique,Rôle de l’imagerie de fluorescence proche infrarouge dans la résection des adénopathies métastatiques dans un modèle animal orthotopique optimisé des cancers des VADS,Corps étrangers des fosses nasales,
Editorial Board Publication date: December 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 6 État de l’art du traitement endoscopique des brèches ostéoméningées du sinus frontal via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: December 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 6 Author(s): V. Patron, V. Roger, S. Moreau, E. Babin, M. Hitier Les brèches méningées du sinus frontal so... περισσότερα »
Perioperative Medicine
: The Value Proposition for Anesthesia? via ScienceDirect Publication: Anesthesiology Clinics Publication date: December 2015 *Source:*Anesthesiology Clinics, Volume 33, Issue 4 Author(s): Michael P.W. Grocott, Michael G. Mythen TeaserPerioperative medicine describes the practice of patient centered, multidisciplinary, and integrated medical care of patients from the moment of contemplation of surgery until full recovery. The value proposition for perioperative medicine rests on defining benefits that outweigh the costs of change. This article discusses the concept of value in the cont...περισσότερα »
NLRC4 inflammasomes: “their appearance and their work was a wheel in the middle of a wheel”
Abstract Cells of the immune system protect us from pathogens, environmental toxins, and even cancer. Our first line of defense, the innate immune response, is partly comprised of cellular barriers (e.g., skin cells that slough off when they are infected, gut cells that produce mucus to trap pathogens, salivary gland cells that regularly flush the oral cavity with saliva, and hepatocytes that make complement proteins, which opsonize bacteria and target them for destruction.) If these mechanisms and barriers are breached, invaders are immediately met by neutrophils and macrophages. ... περισσότερα »
Interactions Between Fatty Acid Transport Proteins, Genes that Encode for Them, and Exercise: A Systematic Review
Abstract Long-chain fatty acid (LCFA) movement into skeletal muscle involves a highly mediated process in which lipid rafts are utilised in the cellular membrane, involving numerous putative plasma membrane-associated LCFA transport proteins. The process of LCFA uptake and oxidation is of particular metabolic significance both at rest and during light to moderate exercise. A comprehensive systematic search of electronic databases was undertaken to investigate whether exercise alters protein and / or gene expression of putative LCFA transport proteins. There were 31 studies meeting... περισσότερα »
“MicroRNA Expression Signature Is Altered in the Cardiac Remodeling Induced by High Fat Diets”
Abstract Recent studies have revealed the involvement of microRNAs (miRNAs) in the control of cardiac hypertrophy and myocardial function. In addition, several reports have demonstrated that high fat (HF) diet induces cardiac hypertrophy and remodeling. In the current study, we investigated the effect of diets containing different percentages of fat on the cardiac miRNA expression signature. To address this question, male C57Bl/6 mice were fed with a low fat (LF) diet or two HF diets, containing 45 kcal% fat (HF45%) and 60 kcal% fat (HF60%) for 10 and 20 weeks. HF60% diet promoted ... περισσότερα »
E11/Podoplanin Protein Stabilization through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine In Vitro Models
Abstract The transmembrane glycoprotein E11 is considered critical in early osteoblast-osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO-A5 cell line we reveal increased E11 protein/mRNA expression (P < 0.001) concomitant with extensive osteocyte dendrite formation and matrix mineralization (P < 0.001). Transfection with E11 significantly increased mRNA levels (P < 0.001), but immunoblotting failed to detect any correlative increases in E11 protein levels, suggestive of post-translational degra...περισσότερα »
Tropical Medicine and Health now available on BioMed Central’s platform
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: Tropical Medicine and Health] *Editor-in-Chief*: Masahiro Hashizume, Nagasaki University, Japan *Submit a Manuscript* *Editorial Board* *Author Instructions* *Article Alerts* Dear Colleague, We are pleased to announce that *Tropical Medicine and Health*, the official journal of the Japanese Society of Tropical Medicine (JSTM), is now available on BioMed Central’s publishing platform. *Aims and Scope* *Tropical Medicine and Health *is an open access, peer-reviewed journal that publishes original research and reviews on all aspects of tropical medicine and global health. T... περισσότερα »
Fatty acyl composition of lysophosphatidylcholine is important in atherosclerosis
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): O.A. Akerele, S.K. Cheema Atherosclerosis is a major cause of death for mankind. Although the pathophysiology of atherosclerosis is a complex and multifactorial process, growing body of evidence has identified phospholipids-mediated signaling as an important factor in the induction and progression of atherosclerosis. Lysophosphatidylcholine (LPC) is a major phospholipid in oxidized low-density lipoprotein, and is generally considered to be atherogenic. However, some studies have shown anti-ath... περισσότερα »
Possible role of granulysin in pathogenesis of osteoarthritis
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Tatjana Kehler, Gordana Laskarin, Drazen Massari, Marin Dominovic, Viktor Persic, Ivan Rosovic, Josip Laginja, Daniel Rukavina Increased presence of immune mediator and cytotoxic/apoptotic molecule granulysin was noticed in different tissues during pathological processes with the domination of Th1 over Th2 mediated immunity. Beside granulysin expression in T and NKT cells, activated NK cells are thought to be the major source of chemotactic 15kDa and cytotoxic 9kDa granulysin in vivo. As NK ce... περισσότερα »
Baicalin may have a therapeutic effect in attention deficit hyperactivity disorder
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Rongyi Zhou, Xinmin Han, Jiaojiao Wang, Jichao Sun Baicalin is a flavonoid purified from Scutellaria baicalensis Georgi. It possesses a variety of pharmacological properties, such as anti-inflammatory, antioxidant, antiapoptotic, and neuro-protective properties, and provides protection against cerebral hemorrhage. However, it is seldom considered a therapeutic in mental disorders. Recent studies showed that baicalin protects cerebral functions against ischemia and has sedative and anxiolytic-l... περισσότερα »
Myalgic encephalomyelitis, chronic fatigue syndrome: An infectious disease
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): R.A. Underhill The etiology of myalgic encephalomyelitis also known as chronic fatigue syndrome or ME/CFS has not been established. Controversies exist over whether it is an organic disease or a psychological disorder and even the existence of ME/CFS as a disease entity is sometimes denied. Suggested causal hypotheses have included psychosomatic disorders, infectious agents, immune dysfunctions, autoimmunity, metabolic disturbances, toxins and inherited genetic factors. Clinical, immunological...περισσότερα »
Mechanism of failure of the Cabrol procedure: A computational fluid dynamic analysis
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): M. Poullis, M. Pullan Sudden failure of the Cabrol graft is common and frequently fatal. We utilised the technique of computational fluid dynamic (CFD) analysis to evaluate the mechanism of failure and potentially improve on the design of the Cabrol procedure. CFD analysis of the classic Cabrol procedure and a number of its variants was performed. Results from this analysis was utilised to generate further improved geometric options for the Cabrol procedure. These were also subjected to CFD an...περισσότερα »
Review of Amyotrophic Lateral Sclerosis, Parkinson’s and Alzheimer’s diseases helps further define pathology of the novel paradigm for Alzheimer’s with heavy metals as primary disease cause
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): Franco Cavaleri Pathologies of neurological diseases are increasingly recognized to have common structural and molecular events that can fit, sometimes loosely, into a central pathological theme. A better understanding of the genetic, proteomic and metabolic similarities between three common neurodegenerative diseases – Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD) – and how these similarities relate to their unique pathological features may shed mo...περισσότερα »
Non-pharmacological treatment for neuropathic pain in children with cancer
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): C. Casanova-García, S. Lerma Lara, M. Pérez Ruiz, D. Ruano Domínguez, E. Santana Sosa Neuropathic pain (NP) associated with childhood cancer is currently a difficult problem to control. It is treated with drugs that not only fail to provide the expected improvements, but which also have side effects. Therefore, the main aim of this pilot study is to assess whether non-pharmacological treatments, Graded Motor Imagery (GMI) and Neural Mobilization (NM), have a positive effect on this pain, thus ... περισσότερα »
On the origins of autism: The Quantitative Threshold Exposure hypothesis
Publication date: December 2015 *Source:*Medical Hypotheses, Volume 85, Issue 6 Author(s): S. Crawford The Quantitative Threshold Exposure (QTE) hypothesis is a multifactorial threshold model that accounts for the cumulative effects of risk factor exposure in both the causation of autism spectrum disorder (ASD) and its dramatic increase over the past 30years. The QTE hypothesis proposes that ASD is triggered by the cumulative effects of high-level exposure to endogenous and environmental factors that act as antigens to impair normal immune system (IS) and associated central nervous ... περισσότερα »
Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS
Publication date: Available online 7 December 2015 *Source:*Neuroscience Research Author(s): Minami Hasegawa, Chikako Hara-Miyauchi, Hiroki Ohta, Kenji Sakimura, Hideyuki Okano, Hirotaka James Okano Diagnostic biomarkers for amyotrophic lateral sclerosis (ALS) have yet to be identified. One of the causes of neuronal cell death in neurodegenerative diseases is abnormal RNA metabolism, although the mechanisms by which this occurs are unclear. Detection of abnormal RNA metabolism in white blood cells (WBCs) could lead to a new biomarker of ALS onset. TAR DNA-binding protein 43kDa (TDP-... περισσότερα »
The power of creative thinking in situations of uncertainties: the almost impossible task of protecting critical infrastructures
A good and scientific analysis starts with a closer look at the conceptualisation at hand. The definition of CIP is not easy because of its wide range. This paper examines infrastructures that are critical and need protection. Each word entails a specific connotation and is characterized by several components. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1NdgJGb via IFTTT
Een glaasje gerecycleerd water?
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De ziekenhuisbacterie MRSA bij Nederlandse varkens en varkenshouders
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Vermeerderen van graszaad voor eigen gebruik
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Gevolgen van beperkte bemesting op grasland
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Onkruidbestrijding in wintertarwe 2002 (Landbouwcentrum Granen Vlaanderen)
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Bestrijding van specifieke probleemonkruiden in aardappelen
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Proeven inzake onkruidbestrijding 2001: landbouwcentrum Voedergewassen
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Onkruidbestrijding in wintergerst 2002 (Landbouwcentrum Granen)
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10 jaar penitentiair tuchtrecht: uitdagingen voor de toekomst
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De gemoderniseerde EU-staatssteunregels: naar meer responsabilisering van de lidstaten
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Het belang van het kind en gezinshereniging onder art. 8 EVRM na het arrest-Jeunesse
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De uitdagingen voor biomethaan
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Overzicht van het Belgisch administratief recht
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Pocketvergisting op het landbouwbedrijf
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Overzicht van het Belgisch administratief recht
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Tweejaarlijks vergistingsforum
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Protecting children in the digital era: the use of alternative regulatory instruments
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Efficient simulation of 3D electromagnetic scattering problems using boundary integral equations
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Misvattingen over natuurlijke ventilatie
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