Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Κυριακή 10 Ιανουαρίου 2016

OtoRhinoLaryngology & Medicine,New Articles,January 11th,2016


Metabolic modeling of clostridia: current developments and applications

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 λεπτό
Anaerobic *Clostridium spp.* is an important bio-production microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (*Clostridium acetobutylicum*, *Clostridium beijerinckii*, *Clostridium butyricum*, *Clostridium cellulolyticum*, *Clostridium ... περισσότερα »

Host receptors for bacteriophage adsorption

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 λεπτό
The adsorption of bacteriophages (phages) onto host cells is, in all but a few rare cases, a *sine qua non* condition for the onset of the infection process. Understanding the mechanisms involved and the factors affecting it is, thus, crucial for the investigation of host-phage interactions. This review provides a survey of the phage host receptors involved in recognition and adsorption and their interactions during attachment. Comprehension of the whole infection process, starting with the adsorption step, can enable and accelerate our understanding of phage ecology and the devel... περισσότερα »

Changes in body composition and growth pattern after adenotonsillectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Changes in body composition and growth pattern after adenotonsillectomy in prepubertal children Publication date: February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 81 Author(s): Alper Koycu, Erdinc Aydin, Sibel Tulgar Kinik Objective Adenotonsillar hypertrophy and chronic tonsillitis are associated with growth interruption during childhood, while adenotonsillectomy has been associated with growth improvement and increased body mass index (BMI). However, no reported study has investigated the effect of adenotonsillectomy on the proportion of body mu... περισσότερα »

Expression of CXCL4 and aquaporin 3 and 10 mRNAs in patients with otitis media with effusion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Expression of CXCL4 and aquaporin 3 and 10 mRNAs in patients with otitis media with effusion Publication date: February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 81 Author(s): Zhe Jin, Sung Ho Cha, Yong-Sung Choi, Young Il Kim, Sun A. Choi, Seung Geun Yeo Purpose Bacterial infections in children with underdeveloped Eustachian tubes are a major cause of otitis media with effusion (OEM), and persistent effusion in the middle ear in these patients is a major cause of surgical intervention. CXCL4 is associated with bacterial infection, and aquaporins 3...περισσότερα »

Factors related to persisting perforations after ventilation tube insertion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Factors related to persisting perforations after ventilation tube insertion Publication date: February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 81 Author(s): Ashley P. O’Connell Ferster, April Michelle Tanner, Kodjo Karikari, Christopher Roberts, Derek Wiltz, Michele M. Carr Objective Over a million ventilation tubes are placed annually in the United States, making this one of the most commonly performed procedures in the field of medicine. Certain factors increase the risk of persistent tympanic membrane perforation following the extrusion of short...περισσότερα »

An apparently untreatable ulcer of the face

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 4 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1kZoibN via IFTTT

ABR thresholds in infants born with CLP and OME and infants with OME

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
ABR thresholds in infants born with CLP and OME and infants with OME Publication date: February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 81 Author(s): H. Sundman, T. Flynn, B. Tengroth, A. Lohmander Objectives The aim of this study was to investigate and compare auditory brainstem response (ABR) thresholds related to otitis media with effusion (OME) in infants with and without cleft palate and/or lip (CP±L). Methods Forty-seven infants with CP±L and 67 infants with OME participated in the study. Hearing thresholds of ears of infants with OME were c... περισσότερα »

Decreased level of osteopontin in children with allergic rhinitis during sublingual immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Decreased level of osteopontin in children with allergic rhinitis during sublingual immunotherapy Publication date: February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 81 Author(s): Chunrui Wang, Kai Wang, Shaoting Liu, Xiaowei Qin, Kewa Chen, Tianhong Zhang Objective Sublingual immunotherapy (SLIT) is proven to be very effective in the treatment of allergic rhinitis (AR), but its regulatory mechanism and biomarkers for predicting efficacy are still unknown. Osteopontin (OPN), as a recently described Th2 inflammation related protein, plays key role i... περισσότερα »

Mannose binding lectin codon 54 polymorphism and susceptibility to recurrent respiratory tract infections in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
: A meta-analysis Publication date: February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 81 Author(s): Ozlem Atan, Ahmet Kucukcelebi, Tahir Atik, Ferda Ozkınay Background There have been studies focused on mannose binding lectin (MBL) polymorphism and susceptibility to recurrent respiratory tract infections (RRTI) with inconclusive results. This present study is a meta-analysis of possible MBL and RRTI association in children. Methods A literature search was performed using Medline and PubMed and abstracts were reviewed for relevance. Any study was co...περισσότερα »

The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia

Pre-eclampsia (PE) is the most frequently encountered medical complication during pregnancy. It is characterized by a rise in systemic vascular resistance with a relatively low cardiac output and hypovolemia, combined with severe proteinuria. Despite the hypovolemia, renin–angiotensin system (RAS) activity is suppressed and aldosterone levels are decreased to the same degree as renin. This suggests […]

20Q: Hearing Aids - The Future Ain't What it Used to Be!

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Back in May of 1994, I wrote an article titled, Update On Programmable Hearing Aids (With An Assist From Yogi Berra). At the time, there were a lot of questions surrounding the use of programmable hearing aids, and I thought it might be appropriate to use several Yogi-isms to help sort out the confusion. With the passing of Yogi this past September, it only seems appropriate to revisit that theme today to look at current issues regarding hearing aid selection and fitting. In a way, it's like "déjà vu all over again." from #Audiology via xlomafota13 on Inoreader http://ift.tt/1OlJWP... περισσότερα »

20Q: Hearing Aids - The Future Ain't What it Used to Be!

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Back in May of 1994, I wrote an article titled, Update On Programmable Hearing Aids (With An Assist From Yogi Berra). At the time, there were a lot of questions surrounding the use of programmable hearing aids, and I thought it might be appropriate to use several Yogi-isms to help sort out the confusion. With the passing of Yogi this past September, it only seems appropriate to revisit that theme today to look at current issues regarding hearing aid selection and fitting. In a way, it's like "déjà vu all over again." from #Audiology via ola Kala on Inoreader http://ift.tt/1OlJWPQ v... περισσότερα »

20Q: Hearing Aids - The Future Ain't What it Used to Be!

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Back in May of 1994, I wrote an article titled, Update On Programmable Hearing Aids (With An Assist From Yogi Berra). At the time, there were a lot of questions surrounding the use of programmable hearing aids, and I thought it might be appropriate to use several Yogi-isms to help sort out the confusion. With the passing of Yogi this past September, it only seems appropriate to revisit that theme today to look at current issues regarding hearing aid selection and fitting. In a way, it's like "déjà vu all over again." from #Audiology via ola Kala on Inoreader http://ift.tt/1OlJWPQ v... περισσότερα »

Some Maine Democrats to press for impeachment of Gov. LePage – News On 6

News On 6 Some Maine Democrats to press for impeachment of Gov. LePage News On 6 But the week ended on a sour note when LePage had to apologize for a racially tinged remark in which he said white girls were being impregnated by out-of-state drug dealers. LePage blamed the media of making too much […]

Non-tuberculous mycobacterial head and neck infections in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
: Analysis of results and complications for various treatment modalities via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 7 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): M. Mahadevan, M. Neeff, G. Van Der Meer, C. Baguley, W.K. Wong, M. Gruber ObjectiveAnalyze the results and complications of various surgical interventions in a large cohort of children with Non-Tuberculous mycobacterial (NTM) head and neck infections and suggest a heuristic treatment protocol for managing this condition while aiming t... περισσότερα »

Hereditary angioedema type 2 presented as an orbital complication of acute rhinosinusitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Hereditary angioedema type 2 presented as an orbital complication of acute rhinosinusitis via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 8 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Battal Tahsin Somuk, Göksel Göktas, Samet Özer, Emrah Sapmaz, Yalcın Bas Hereditary angioedema is an autosomal dominant and life-threatening disorder characterized by recurrent episodes of non-pitting edema affecting the skin, respiratory system and digestive tracts and caused by a congenital deficiency or function d...περισσότερα »

Local anesthesia on facial nerve blood flow

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Effect of local anesthesia on facial nerve blood flow and muscle action potential via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 8 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Cheol Hee Choi, Sok Cheon Pak, Chul Ho Jang Background & Objective: The effect of direct application of local lidocaine with epinephrine on the facial nerve (FN) has not been reported. The aim of this study is to assess the effects of 2% lidocaine with 1:100,000 epinephrine at clinically relevant concentrations in a rat FN mo...περισσότερα »

Concurrent Cetuximab (ERBITUX®) and Intensity Modulated Radiotherapy (IMRT) With Ipilimumab (YERVOY®) in Locally Advanced Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®) and Intensity Modulated Radiotherapy (IMRT) With Ipilimumab (YERVOY®) in Locally Advanced Head and Neck Cancer: *Condition*: Cancer of Head and Neck *Intervention*: Drug: Cetuximab/IMRT Plus Ipilimumab *Sponsors*: University of Pittsburgh; National Cancer Institute (NCI) ArmsAssigned InterventionsExperimental: Treatment Arm Cetuximab/IMRT Plus Ipilimumab (14 Week Regimen) IMRT, Weeks 2-8: 70-74.0 Gy with 2.0 Gy daily fractions delivered in 7-7.5 weeks Cetuximab, Weeks 1-8 Week 1: 400 mg/m2 Weeks 2-8 (concurrent with IMRT):... περισσότερα »

Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma: *Condition*: Oropharyngeal Cancer *Intervention*: *Sponsor*: New Mexico Cancer Care Alliance Cancer of the oropharynx (middle, side and back walls of the throat; back of the tongue; soft palate, and tonsils), or oropharyngeal squamous cell carcinoma (OPSCC), has been on the rise in the United States. Human papillomavirus (HPV) has been recognized in many of these cancers, and testing for HPV has contributed to the higher reported rates of OPSCC. In this study, o...περισσότερα »

Optional Sub-study to Intraoperative Imaging With ICG Registry

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Optional Sub-study to Intraoperative Imaging With ICG Registry The primary goal of this optional sub-study is to record what tissues fluoresce in the operating room, and then to identify if these lesions are cancer when the histopathology is performed. ConditionInterventionLung, Prostate, Breast, Colon, Pancreatic, Renal, Bladder,Thyroid, Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut) Cancer Cancer of the Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut), Sarcoma Cancer Cancer of Neuro-onc, Parathyroid, Desmoid Tumors, Melanoma CancerOther: data collection

The role of autophagy in HNSCC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
The role of autophagy in squamous cell carcinoma of the head and neck via ScienceDirect Publication: Oral Oncology Publication date: Available online 7 January 2016 *Source:*Oral Oncology Author(s): Benjamin Cosway, Penny Lovat Half a million new head and neck cancers are diagnosed each year worldwide. Although traditionally thought to be triggered by alcohol and smoking abuse, there is a growing subset of oropharyngeal cancers driven by the oncogenic human papilloma virus (HPV). Despite advances in both surgical and non-surgical treatment strategies, survival rates have remained relat...περισσότερα »

A survey on chronic rhinosinusitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
A survey on chronic rhinosinusitis: opinions from experts of 50 countries: AbstractChronic rhinosinusitis (CRS) is a very prevalent inflammatory disease. Treatments vary in different countries. In the present study, we explored the approaches of physicians in 50 countries. In this cross-sectional study, a rhinosinusitis survey (RSS) was completed by Honorary and Corresponding Members (otorhinolaryngologists) of the Italian Society of Rhinology. In 79.1 % of the 50 countries, the proportion of patients suffering from CRS was 15 %. Nasal symptoms were more intense in winter (46 % of ... περισσότερα »

Photocoagulation therapy for laryngeal dysplasia using angiolytic lasers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Photocoagulation therapy for laryngeal dysplasia using angiolytic lasers: AbstractIn the management of laryngeal pre-cancerous lesions such as dysplasia or carcinoma in situ (CIS), it is important that lesion regression occur without any complications. As a minimally invasive treatment option, photocoagulation therapy using angiolytic lasers has been attracting attention. Therapeutic effects have been reported for this type of treatment, however, vocal function after treatment has not been well discussed. In this retrospective case series, we examined the therapeutic effects of pho... περισσότερα »

Endolymphatic duct blockage

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Endolymphatic duct blockage: quality of life assessment of a novel surgical technique for Ménière disease: AbstractThe aim of this study is to evaluate the quality of life (QOL) of patients treated by endolymphatic duct blockage (EDB) for Ménière’s disease with a dedicated questionnaire. This is a retrospective cross-sectional study which included 54 patients diagnosed with severe, refractory Ménière’s disease according to the AAO-HNS criteria and treated with EDB between 2010 and 2013. Answers to the first 38 questions have assigned scores from 0 to 4 (0 corresponding to the poore... περισσότερα »

20Q: Hearing Aids – The Future Ain’t What it Used to Be!

Back in May of 1994, I wrote an article titled, Update On Programmable Hearing Aids (With An Assist From Yogi Berra). At the time, there were a lot of questions surrounding the use of programmable hearing aids, and I thought it might be appropriate to use several Yogi-isms to help sort out the confusion. With […]

Some Maine Democrats to press for impeachment of Gov. LePage – News On 6

News On 6 Some Maine Democrats to press for impeachment of Gov. LePage News On 6 But the week ended on a sour note when LePage had to apologize for a racially tinged remark in which he said white girls were being impregnated by out-of-state drug dealers. LePage blamed the media of making too much […]

Immediate hypersensitivity to iodinated contrast media: diagnostic accuracy of skin tests and intravenous provocation test with low dose

Abstract Background The diagnosis of HSR to iodinated contrast media (ICM) ICM is challenging based on clinical history and skin tests. Objective This study evaluates the negative predictive value (NPV) of skin tests and intravenous provocation test (IPT) with low-dose ICM in patients with suspected immediate hypersensitivity reaction (HSR) to ICM. Methods Thirty seven patients […]

Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons

Abstract Amylin is a pancreatic β-cell hormone that acts as a satiating signal to inhibit food intake by binding to amylin receptors (AMY) and activating a specific neuronal population in the area postrema (AP). AMY are heterodimers that include a calcitonin receptor (CTR) subunit (CTRa or CTRb) and a member of the receptor activity modifying […]

Adult cortical plasticity: a murine model? (Commentary on Smolders et al.)

Abstract The ability of neurons to undergo experience-dependent changes in form and function early in an organism’s development is an area of intense research. The seminal studies of Hubel and Wiesel established the feline (Hubel and Wiesel, 1963) and later the macaque visual systems (Hubel et al., 1977) as premier animal models for investigating experienced-based […]

Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55)

Summary Objective The aim of this study was to examine measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) across age, sex, and time in a representative sample of children with newly diagnosed epilepsy. Methods Data come from 373 children enrolled in the Health-related Quality of Life in Children with […]

Medial Olivocochlear Reflex as a Protection Mechanism from Noise-Induced Hearing Loss Revealed

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
A Role of Medial Olivocochlear Reflex as a Protection Mechanism from Noise-Induced Hearing Loss Revealed in Short-Practicing Violinists: by Sho Otsuka, Minoru Tsuzaki, Junko Sonoda, Satomi Tanaka, Shigeto Furukawa Previous studies have indicated that extended exposure to a high level of sound might increase the risk of hearing loss among professional symphony orchestra musicians. One of the major problems associated with musicians’ hearing loss is difficulty in estimating its risk simply on the basis of the physical amount of exposure, i.e. the exposure level and duration. The aim ...περισσότερα »

Opioid overdose and respiratory compromise

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
5 things EMS providers need to know about opioid overdose and respiratory compromise: By Bob Sullivan Timely recognition, airway management, administration of naloxone (Narcan), and continuous assessment of oxygenation and ventilation can be lifesaving for patients who overdose on opioids. Here are five things every EMT and paramedic needs to know about caring for patients who overdose on opioids: *1. Opioids cause respiratory compromise and naloxone can reverse it* Opioid overdose is the leading cause of death among people from 25 to 60 years of age, accounting for more death... περισσότερα »

Fungus ball of the paranasal sinuses

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Bola fúngica sinusal: análisis de nuestra casuística via Acta Otorrinolaringológica Española [image: a) Ocupación de seno maxilar izquierdo con microcalcificaciones. b) Ocupación de ...] [image: Bola fúngica maxilar con restos de mucosa inflamatoria.] [image: a) Aspecto de una bola fúngica en el interior del seno maxilar izquierdo tras ...] *Source:*Acta Otorrinolaringológica Española Author(s): Joan Lop-Gros, Juan R. Gras-Cabrerizo, Carolina Bothe-González, Juan R. Montserrat-Gili, Anna Sumarroca-Trouboul, Humbert Massegur-Solench Introducción y objetivosLa bola fúngica es la forma má... περισσότερα »

Tracheal osteochondromas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Osteocondromas traqueales, hallazgo casual via Acta Otorrinolaringológica Española [image: Image for figure Figura 1] [image: Image for figure Figura 2] *Source:*Acta Otorrinolaringológica Española Author(s): Lina Rosique López

Isolated olfactory bulbs agenesis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
: An extremely rare entity via Acta Otorrinolaringológica Española [image: Comparison of proper anatomical configuration of the gyri rectus (1), normal ...] *Source:*Acta Otorrinolaringológica Española Author(s): Cristiana Coimbra, André Cunha, Edite Coimbra Ferreira, Artur Condé

The ontogeny of the superior semicircular canal and tegmen tympani

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Explicación ontogénica para la asociación entre dehiscencia del tegmen tympani y dehiscencia del canal semicircular superior via Acta Otorrinolaringológica Española *Source:*Acta Otorrinolaringológica Española Author(s): Jesús José Fraile Rodrigo, Ana I. Cisneros, Jesús Obón, Carmen Yus, Rafael Crovetto, Miguel A. Crovetto, Jaime Whyte ObjetivosAnalizar la ontogenia del canal semicircular superior y del tegmen tympani y determinar si hay factores embriológicos comunes que expliquen la dehiscencia asociada de ambos.MétodosSe han analizado 77 series embriológicas humanas de edades compr... περισσότερα »

Idiopathic Ulcerative Laryngitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
: An uncommon disease via Acta Otorrinolaringológica Española [image: Fiberendoscopic image with white light (a) and NBI (b). Plain background ulcers ...] [image: Intraoperative image of laryngeal lesions before (a) and after (b) biopsies. ...] [image: Pictures of the larynx with white light (a) and NBI after the resolution of the ...] *Source:*Acta Otorrinolaringológica Española Author(s): Meritxell Valls, Isabel Vilaseca

Acta Otorrinolaringológica Española

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Osteocondromas traqueales, hallazgo casual Publication date: Available online 7 January 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Lina Rosique López Utilidad de la petrosectomía subtotal en el tratamiento de la otitis media crónica Publication date: Available online 2 January 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Xabier Altuna, Juan José Navarro, Miren Goiburu, Idoia Palicio Introducción y Objetivos La petrosectomía subtotal consiste en la eliminación completa de todas las celdas neumáticas del hueso temporal. La Trompa de Eustaquio se ...περισσότερα »

Venous malformation of right angular vein

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Venous malformation of right angular vein via Acta Otorrinolaringológica Española [image: Serial contrast enhanced CT of the nose and paranasal sinuses showing the right ...] [image: (A) Pre-operative photograph showing swelling between right medial canthus and ...] [image: Haematoxylin and eosin stain of the specimen showing many vessels of dilated ...] *Source:*Acta Otorrinolaringológica Española Author(s): Hemanth Vamanshankar, Jyotirmay Shyamsundar Hegde, Pradipta Kumar Parida

Subtotal petrosectomy is the complete exenteration of all air cell tracts of the temporal bone. The isthmus of the Eustachian tube is obliterated and the external auditory canal is closed

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Utilidad de la petrosectomía subtotal en el tratamiento de la otitis media crónica via Acta Otorrinolaringológica Española Publication date: Available online 2 January 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Xabier Altuna, Juan José Navarro, Miren Goiburu, Idoia Palicio Introducción y ObjetivosLa petrosectomía subtotal consiste en la eliminación completa de todas las celdas neumáticas del hueso temporal. La Trompa de Eustaquio se oblitera y el conducto auditivo externo se cierra. El objetivo de este estudio es describir el uso de esta técnica en el manejo de determ...περισσότερα »

Olfaction Contributes to Navigation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Olfaction Contributes to Pelagic Navigation in a Coastal Shark: by Andrew P. Nosal, Yi Chao, John D. Farrara, Fei Chai, Philip A. Hastings How animals navigate the constantly moving and visually uniform pelagic realm, often along straight paths between distant sites, is an enduring mystery. The mechanisms enabling pelagic navigation in cartilaginous fishes are particularly understudied. We used shoreward navigation by leopard sharks (*Triakis semifasciata*) as a model system to test whether olfaction contributes to pelagic navigation. Leopard sharks were captured alongshore, transp... περισσότερα »

Diagnosis of temporomandibular joint disorders

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
: rational indication of imaging exams via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 8 January 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Luciano Ambrosio Ferreira, Eduardo Grossmann, Eduardo Januzzi, Marcos Vinicius Queiroz de Paula, Antonio Carlos Pires Carvalho IntroductionKnowledge of the different imaging tests and their appropriate indications is crucial to establish the diagnosis of temporomandibular disorders, especially in patients with overlapping signs and symptoms.ObjectiveTo present and asse...περισσότερα »

Vestibular rehabilitation with visual stimuli

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Vestibular rehabilitation with visual stimuli in peripheral vestibular disorders via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 8 January 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Andréa Manso, Mauricio Malavasi Ganança, Heloisa Helena Caovilla IntroductionVisual stimuli can induce vestibular adaptation and recovery of body balance.ObjectiveTo verify the effect of visual stimuli by digital images on vestibular and body balance rehabilitation of peripheral vestibular disorders.MethodsClinical, randomized,... περισσότερα »

Concurrent fungus ball and squamous cell carcinoma of the maxillary sinus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Concurrent fungus ball and squamous cell carcinoma of the maxillary sinus via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 7 January 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, D.N. Johnson, J. de Souza, E. Blair [image: Axial non-contrast CT image in the soft tissue window shows opacification of the ...] [image: Photomicrograph at 20×original magnification of a hematoxylin and eosin stained ...]

Desmoplastic Melanocytic Nevus of Oral Mucosa

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Desmoplastic Melanocytic Nevus of Oral Mucosa: AbstractThe desmoplastic melanocytic nevus is an uncommon variant that easily may be confused with a fibrohistiocytic neoplasm or a desmoplastic melanoma. It is believed that the following report describes the first known example of a desmoplastic melanocytic nevus arising in the oral mucosa. The histopathologic and immunohistochemical features that allow separation from other microscopically similar pathoses are stressed.

Head and Neck Schwannomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Head and Neck Schwannomas: 20-Year Experience of a Single Institution Excluding Cutaneous and Acoustic Sites: AbstractWhile head and neck sites comprise the most common location of schwannomas, clinicopathologic data regarding those tumors occurring in non-acoustic and non-cutaneous locations are relatively sparse. In this study, therefore, we sought to examine retrospectively the clinical and pathologic features of head and neck schwannomas excised at our institution over a 20-year period. During this period, we identified a total cohort of 85 patients, which included 36 males (42...περισσότερα »

Productivity outcomes following endoscopic sinus surgery for recurrent acute rhinosinusitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Productivity outcomes following endoscopic sinus surgery for recurrent acute rhinosinusitis: Objectives/Hypothesis We sought to evaluate preoperative and postoperative productivity losses and quality of life (QOL) impairment reported by patients with recurrent acute rhinosinusitis (RARS) as compared to patients with chronic rhinosinusitis without nasal polyposis (CRSsNP). Study Design Prospective, multi-institutional, nested case–control. Methods Participants with RARS (n = 20) and CRSsNP (n = 20) undergoing endoscopic sinus surgery (ESS) were enrolled as part of a prospective cohort...περισσότερα »

Reversal of rocuronium-induced neuromuscular blockade by sugammadex allows for optimization of neural monitoring of the recurrent laryngeal nerve

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Reversal of rocuronium-induced neuromuscular blockade by sugammadex allows for optimization of neural monitoring of the recurrent laryngeal nerve: Objectives/Hypothesis The use of neuromuscular blocking agent may effect intraoperative neuromonitoring (IONM) during thyroid surgery. An enhanced neuromuscular-blockade (NMB) recovery protocol was investigated in a porcine model and subsequently clinically applied during human thyroid neural monitoring surgery. Study Design Prospective animal and retrospective clinical study. Methods In the animal experiment, 12 piglets were injected with... περισσότερα »

Immunoglobulin G4 related disease : Neck abscess

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Case 24-2009: a 26-year-old woman with painful swelling of the *neck* RC Cabot, NL Harris, JAO Shepard… - … England Journal of …, 2009 - Mass Medical Soc *...* no discrete mass, sialolith, sialodocholith, ductal dilatation, adjacent phlegmon, *abscess*, cyst, significant *...* evaluation was the exclusion of tuberculosis — specifically, mycobacterial *cervical* lymphadenitis *...* Arch Otolaryngol Head *Neck* Surg 1990;116:1055-1060 CrossRef | Web of *...* Neck abscess: An unusual clinical presentation of immunoglobulin G4 related disease by Giancarlo Tirelli, Nicoletta Gardenal, G... περισσότερα »

Electrically evoked compound action potential (ECAP) in cochlear implant children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
: Changes in auditory nerve response in first year of cochlear implant use via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 8 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Laila M. Telmesani, Nithreen M. Said AimRecording of the electrically evoked compound action potential (ECAP) of the auditory nerve in cochlear implant (CI) patients represents an option to assess changes in auditory nerve responses and the interaction between the electrode bundle and the neural tissue over time. The aim of the pres... περισσότερα »

Management of CSF leakage after microsurgery for vestibular schwannoma via the middle cranial fossa approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Management of CSF leakage after microsurgery for vestibular schwannoma via the middle cranial fossa approach: AbstractMicrosurgery is one of the primary current standard options for the treatment of vestibular schwannoma (VS). Especially the middle cranial fossa (MCF) approach is a safe and efficacious technique for the preservation of hearing and facial nerve function in small VS. Postoperative complications are rare, although a leakage of cerebrospinal fluid (CSF) is common. The aim of this study was to analyze postoperative CSF leaks and to describe strategies for postoperative ...περισσότερα »

Modified facelift incision for partial parotidectomy versus bayonet-shaped incision

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
*Modified facelift incision for partial parotidectomy versus bayonet-shaped incision: a comparison using visual analog scale: * Abstract*The aim of this study is to show differences between a modified facelift incision (MFI) for partial parotidectomy versus a bayonet-shaped incision (BSI). 24 patients presenting with a parotid tumor were surgically treated with a partial parotidectomy using a MFI. We generated a “matched pair control group” regarding age, tumor size and gender, who received a BSI. A questionnaire was sent to all patients and relevant data reviewed. The cosmetic sati... περισσότερα »

FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal SCCs

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma via ScienceDirect Publication: Oral Oncology Publication date: Available online 8 January 2016 *Source:*Oral Oncology Author(s): L. Ozretić, S. Wagner, C.U. Huebbers, S. Gattenlöhner, J.P. Klussmann, D. Beutner, T. Zander, R. Buettner, A. Quaas The hamster model of sequential oral oncogenesis E Vairaktaris, S Spyridonidou, V Papakosta, A Vylliotis… - Oral oncology, 2008 - Elsevier *...* Oral *squamous* *cell* *carcinoma* (OSCC) is a common *cancer*, characterised by poor prognosis and low surviv... περισσότερα »

Afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Christine H. Chung, Michelle A. Rudek, Hyunseok Kang, Shanthi Marur, Pritish John, Nancy Tsottles, Sarah Bonerigo, Andy Veasey, Ana Kiess, Harry Quon, Anthony Cmelak, Barbara A. Murphy, Jill Gilbert Introduction Afatinib is an ErbB family receptor inhibitor with efficacy in head and neck s...περισσότερα »

Efficacy of the Sequential Administration of Melatonin, Hydroxyzine, and Chloral Hydrate for Recording Sleep EEGs in Children

Sedation of children for electroencephalography (EEG) recordings is often required. Chloral hydrate (CH) requires medical clearance and continuous monitoring. To try to reduce personnel and time resources associated with CH administration, a new sedation policy was formulated. This study included all children who underwent an EEG during a consecutive 3-month period following the implementation of […]

Esthesioneuroblastomas (ENBs)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Long-term outcomes of patients with esthesioneuroblastomas: A cohort from a single institution Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Zhen-zhen Yin, Li Gao, Jing-wei Luo, Jun-lin Yi, Xiao-dong Huang, Yuan Qu, Kai Wang, Shi-ping Zhang, Jian-ping Xiao, Guo-zhen Xu, Ye-xiong Li Objective Esthesioneuroblastoma is a rare cancer. The purpose of this study was to review the long-term outcomes of patients with esthesioneuroblastomas (ENBs) who were treated at a single institution. Materials and methods One hundred thirteen patients with biopsy-proven E...περισσότερα »

Progression of oral potentially malignant disorder : MicroRNA-31 upregulation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Kai-Feng Hung, Chung-Ji Liu, Peng-Chih Chiu, Jiun-Sheng Lin, Kuo-Wei Chang, Wen-Yu Shih, Shou-Yen Kao, Hsi-Feng Tu Objectives MicroRNAs (miRNAs, miRs) have shown diagnostic and prognostic potential for oral cancer but their role in oral potentially malignant disorder (OPMD) has been less investigated. We aimed to assess whether miR-21and miR-31, two of the most relevant miRNAs in oral cancer, are useful as... περισσότερα »

Pathology review of head and neck oncology specimens

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Discordance in routine second opinion pathology review of head and neck oncology specimens: A single-center five year retrospective review Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Gefei Alex Zhu, Ruth Lira, Alexander Dimitrios Colevas Objectives Second opinion review of pathology specimens is a common institutional practice, supported by large retrospective studies demonstrating significant histologic discordance. Since the most recent study of head and neck-specific pathology review was conducted, routine HPV and EBV testing is now recommended for...περισσότερα »

CD19+IL-10+ regulatory B cells affect survival of tongue SCC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
CD19+IL-10+ regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4+ T cells to CD4+Foxp3+ regulatory T cells Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Xi Zhou, Yu-Xiong Su, Xiao-Mei Lao, Yu-Jie Liang, Gui-Qing Liao Objectives Increase of regulatory T cells (Tregs) in the tumor microenvironment predicts worse survival of patients with various types of cancer including tongue squamous cell carcinoma (TSCC). Recently, the cross-talk between Tregs and regulatory B cells (Bregs) has been shown in several tum... περισσότερα »

Sentinel lymph node biopsy in cT1–T2N0 oral cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Cost–utility of sentinel lymph node biopsy in cT1–T2N0 oral cancer Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Naomi van der Linden, Géke B. Flach, Remco de Bree, Carin A. Uyl-de Groot Objectives To calculate the cost–utility of different strategies for the detection of occult lymph node metastases in cT1–T2N0 oral cancer. Methods A decision tree followed by a Markov model was designed to compare the cost–utility of the following strategies: (a) USgFNAC (ultrasound guided fine needle aspiration cytology), (b) SLNB (sentinel lymph node biopsy), (c) US... περισσότερα »

Oral microbiome,Periodontitis and risk of HNC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Oral microbiome, periodontitis and risk of head and neck cancer Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Leonardo Victor Galvão-Moreira, Maria Carmen Fontoura Nogueira da Cruz A wide range of studies has been successfully exploring the association between the human microenvironment, sustained inflammation, and cancer. Growing evidence has then emerged in this field over the past few years. Nevertheless, reliable data addressing the impact of the oral microbiome and periodontitis on the pathogenesis and risk of head and neck malignancies remain sca...περισσότερα »

Metabolic modeling of clostridia: current developments and applications

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 40 δευτερόλεπτα
Anaerobic *Clostridium spp.* is an important bio-production microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (*Clostridium acetobutylicum*, *Clostridium beijerinckii*, *Clostridium butyricum*, *Clostridium cellulolyticum*, *Clostridium ... περισσότερα »

Host receptors for bacteriophage adsorption

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 40 δευτερόλεπτα
The adsorption of bacteriophages (phages) onto host cells is, in all but a few rare cases, a *sine qua non* condition for the onset of the infection process. Understanding the mechanisms involved and the factors affecting it is, thus, crucial for the investigation of host-phage interactions. This review provides a survey of the phage host receptors involved in recognition and adsorption and their interactions during attachment. Comprehension of the whole infection process, starting with the adsorption step, can enable and accelerate our understanding of phage ecology and the devel... περισσότερα »

Platinum on chemoradiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Clinical recommendations for defining platinum unsuitable head and neck cancer patient populations on chemoradiotherapy: A literature review Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Myung-Ju Ahn, Anil D’Cruz, Jan B. Vermorken, Jo-Pai Chen, Imjai Chitapanarux, Huy Quoc Thinh Dang, Alex Guminski, Danita Kannarunimit, Tong-Yu Lin, Wai Tong Ng, Keon-Uk Park, Anthony Tak Cheung Chan Toxicities resulting from platinum based chemotherapy in head and neck cancer is a cause for much concern. There is a lack of clinical criteria for defining these patient po... περισσότερα »

DNA methylation markers for oral pre-cancer progression

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
: A critical review Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Krithiga Shridhar, Gagandeep Kaur Walia, Aastha Aggarwal, Smriti Gulati, A.V. Geetha, Dorairaj Prabhakaran, Preet K. Dhillon, Preetha Rajaraman Although oral cancers are generally preceded by a well-established pre-cancerous stage, there is a lack of well-defined clinical and morphological criteria to detect and signal progression from pre-cancer to malignant tumours. We conducted a critical review to summarize the evidence regarding aberrant DNA methylation patterns as a potential diagn... περισσότερα »

Efficacy of the Sequential Administration of Melatonin, Hydroxyzine, and Chloral Hydrate for Recording Sleep EEGs in Children

Sedation of children for electroencephalography (EEG) recordings is often required. Chloral hydrate (CH) requires medical clearance and continuous monitoring. To try to reduce personnel and time resources associated with CH administration, a new sedation policy was formulated. This study included all children who underwent an EEG during a consecutive 3-month period following the implementation of […]

Issue Information – Editorial Board

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1REUcHc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Oral Oncology

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Editorial Board/Aims & Scope Publication date: February 2016 *Source:*Oral Oncology, Volume 53 DNA methylation markers for oral pre-cancer progression: A critical review Publication date: February 2016 *Source:*Oral Oncology, Volume 53 Author(s): Krithiga Shridhar, Gagandeep Kaur Walia, Aastha Aggarwal, Smriti Gulati, A.V. Geetha, Dorairaj Prabhakaran, Preet K. Dhillon, Preetha Rajaraman Although oral cancers are generally preceded by a well-established pre-cancerous stage, there is a lack of well-defined clinical and morphological criteria to detect and signal progression fr... περισσότερα »

Nasal septal abscess caused by medication related osteonecrosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
A case of nasal septal abscess caused by medication related osteonecrosis in breast cancer patient via Auris Nasus Larynx Publication date: Available online 8 January 2016 *Source:*Auris Nasus Larynx Author(s): Mayuka Maeda, Takeshi Matsunobu, Takaomi Kurioka, Akihiro Kurita, Akihiro Shiotani Antiresorptive drugs have been widely used to treat patients with hypercalcemia caused by malignancy, bone metastasis, multiple myeloma, and osteoporosis. However, it is well known that antiresorptive drugs can cause osteonecrosis of the jaw (ONJ). Herein, we report a rare case of nasal septal ab... περισσότερα »

Aktuelle Methoden zur Modellierung des Stimmgebungsprozesses

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Aktuelle Methoden zur Modellierung des Stimmgebungsprozesses: Zusammenfassung HintergrundDie Stimmgebung ist ein Prozess, der noch immer in vielen Details nicht verstanden ist. Neben der beobachtenden Forschung versuchen seit längerer Zeit Grundlagenwissenschaftler die Physik der Stimme zu erklären, indem sie versuchen, die Stimmbildung nachzubauen. Dieser Prozess wird als Modellierung bezeichnet. Die Erkenntnisse dieses Forschungszweigs sind vielen Berufsgruppen, die mit Stimme zu tun haben, wie Gesangspädagogen, Stimmtherapeuten und Sprecherziehern, aber auch zum Teil HNO-Ärzten... περισσότερα »

Die Bedeutung von MiRNA für das Kopf-Hals-Karzinom

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Die Bedeutung von MiRNA für das Kopf-Hals-Karzinom: ZusammenfassungTrotz optimierter Therapiemaßnahmen hat sich das Überleben von Kopf-Hals-Karzinom-Patienten in den vergangenen Jahren nur geringfügig verbessert. Den Hauptgrund stellen Metastasen und lokoregionäre Rezidive mit erhöhter Resistenz gegenüber Strahlen- oder Chemotherapie dar. MiRNA regulieren viele zelluläre Prozesse in der Karzinogenese, der Entstehung von Therapieresistenz und Metastasierung des Kopf-Hals-Karzinoms. Daher besitzen MiRNA einen bedeutenden Stellenwert in der Biomarkerforschung. Die Erstellung von MiRNA... περισσότερα »

Pediatric Aspects of Headache Classification in the International Classification of Headache Disorders—3 (ICHD-3 beta version)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Pediatric Aspects of Headache Classification in the International Classification of Headache Disorders—3 (ICHD-3 beta version): AbstractThis analysis looks at the applicability of the International Classification of Headache Disorders—3 beta (ICHD-3 beta) to various headache syndromes of children and adolescents. Areas of similarities and differences between adult and pediatric headaches are addressed as they relate to the ICHD-3 beta.

Connexin 43 (Cx43) Expression in Laryngeal Squamous Cell Carcinomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Connexin 43 (Cx43) Expression in Laryngeal Squamous Cell Carcinomas: Preliminary Data on Its Possible Prognostic Role: AbstractThe aim of the report is to evaluate the prognostic and predictive role of Connexin 43 (Cx43) expression in laryngeal squamous cell carcinomas. Eighty-seven previously untreated patients submitted to laryngectomy ± neck dissection ± radiotherapy were enrolled in this retrospective study. The original primary tumor slides were reassessed, tumor grade and stage reviewed, and Cx43 immunohistochemical analysis performed: only cytoplasmic membranous staining of ...περισσότερα »

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Parsing interindividual drug variability: an emerging role for systems pharmacology

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Parsing interindividual drug variability: an emerging role for systems pharmacology

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Echinococcus multilocularis in Kyrgyzstan: similarity in the Asian EmsB genotypic profiles from village populations of Eastern mole voles (Ellobius tancrei) and dogs in the Alay valley

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Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)

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Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)

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The La-Related Proteins, a Family with Connections to Cancer

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The La-Related Proteins, a Family with Connections to Cancer

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Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

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Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

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The association between a biomarker score for fruit and vegetable intake and incident type 2 diabetes: the EPIC-Norfolk study

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PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

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enviPath – The environmental contaminant biotransformation pathway resource

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Risk factors for Echinococcus coproantigen positivity in dogs from the Alay valley, Kyrgyzstan

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Human cystic and alveolar echinococcosis in the Tibet Autonomous Region (TAR), China

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Parsing interindividual drug variability: an emerging role for systems pharmacology

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The La-Related Proteins, a Family with Connections to Cancer

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Parsing interindividual drug variability: an emerging role for systems pharmacology

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Parsing interindividual drug variability: an emerging role for systems pharmacology

Wiley Interdisciplinary Reviews. Systems Biology and Medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTiWf via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mPrKXu via IFTTT

Echinococcus multilocularis in Kyrgyzstan: similarity in the Asian EmsB genotypic profiles from village populations of Eastern mole voles (Ellobius tancrei) and dogs in the Alay valley

Journal of Helminthology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTjcE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OWA8Bq via IFTTT

The La-Related Proteins, a Family with Connections to Cancer

Biomolecules from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYThBw via IFTTT

Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)

Biomolecules from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1w0tu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mPrKXq via IFTTT

Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Biomolecules from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1vYlp via IFTTT

The La-Related Proteins, a Family with Connections to Cancer

Biomolecules from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYThBw via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OWAb06 via IFTTT

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

Journal of Visualized Experiments : JoVE from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTgOe via IFTTT

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

Journal of Visualized Experiments : JoVE from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTgOe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mPrKHa via IFTTT

Immediate hypersensitivity to iodinated contrast media: diagnostic accuracy of skin tests and intravenous provocation test with low dose

Abstract Background The diagnosis of HSR to iodinated contrast media (ICM) ICM is challenging based on clinical history and skin tests. Objective This study evaluates the negative predictive value (NPV) of skin tests and intravenous provocation test (IPT) with low-dose ICM in patients with suspected immediate hypersensitivity reaction (HSR) to ICM. Methods Thirty seven patients […]

The association between a biomarker score for fruit and vegetable intake and incident type 2 diabetes: the EPIC-Norfolk study

European journal of clinical nutrition from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1w2Sn via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OWAaZY via IFTTT

enviPath – The environmental contaminant biotransformation pathway resource

Nucleic Acids Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTjJN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mPrKH2 via IFTTT

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

Current topics in microbiology and immunology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTk0c via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OWAaZW via IFTTT

Risk factors for Echinococcus coproantigen positivity in dogs from the Alay valley, Kyrgyzstan

Journal of Helminthology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1vZG6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mPrKH0 via IFTTT

All the microbiology nematodes can teach us

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Be it their pervasiveness, experimental tractability or their impact on human health and agriculture, nematode-bacterium associations are far-reaching research subjects. Although the omics hype did not spare them and helped reveal mechanisms of communication and exchange between the associated partners, a huge amount of knowledge still awaits to be harvested from their study. Here, I summarize and compare the kind of research that has been already performed on the model nematode *Caenorhabditis elegans* and on symbiotic nematodes, both marine and entomopathogenic ones. The emergin... περισσότερα »

Potential pathogens, antimicrobial patterns, and genotypic diversity of Escherichia coli isolates in constructed wetlands treating swine wastewater

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
*E. coli* populations originating from swine houses through constructed wetlands were analyzed for potential pathogens, antimicrobial susceptibility patterns, and genotypic diversity. *E. coli* isolates (n = 493) were screened for the presence of the following virulence genes: *stx*1, *stx*2,and eae (Shiga toxin-producing *E. coli* [STEC]), heat-labile enterotoxin (LT) genes and heat stable toxin STa and STb (enterotoxigenic *E. coli* (ETEC), cytotoxin necrotizing factors 1 and 2 (*cnf*1 and *cnf*2 [necrotoxigenic *E. coli*- NTEC]), as well as O and H antigens, and the presence of... περισσότερα »

Immediate hypersensitivity to iodinated contrast media: diagnostic accuracy of skin tests and intravenous provocation test with low dose

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Background The diagnosis of HSR to iodinated contrast media (ICM) ICM is challenging based on clinical history and skin tests. Objective This study evaluates the negative predictive value (NPV) of skin tests and intravenous provocation test (IPT) with low-dose ICM in patients with suspected immediate hypersensitivity reaction (HSR) to ICM. Methods Thirty seven patients… Continue reading Immediate hypersensitivity to iodinated contrast media: diagnostic accuracy of skin tests and intravenous provocation test with low dose

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

Current topics in microbiology and immunology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTk0c via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

enviPath – The environmental contaminant biotransformation pathway resource

Nucleic Acids Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTjJN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Risk factors for Echinococcus coproantigen positivity in dogs from the Alay valley, Kyrgyzstan

Journal of Helminthology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1vZG6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Human cystic and alveolar echinococcosis in the Tibet Autonomous Region (TAR), China

Journal of Helminthology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1w10z via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Echinococcus multilocularis in Kyrgyzstan: similarity in the Asian EmsB genotypic profiles from village populations of Eastern mole voles (Ellobius tancrei) and dogs in the Alay valley

Journal of Helminthology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTjcE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Parsing interindividual drug variability: an emerging role for systems pharmacology

Wiley Interdisciplinary Reviews. Systems Biology and Medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTiWf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)

Biomolecules from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1w0tu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

The La-Related Proteins, a Family with Connections to Cancer

Biomolecules from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYThBw via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Biomolecules from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1vYlp via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

Journal of Visualized Experiments : JoVE from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PYTgOe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Neurogenesis and anxiety-like behavior in male California mice during the mate’s postpartum period

Abstract Our understanding of postpartum anxiety (PPA) in fathers is limited, despite the negative consequences of anxiety on the father and child. Offspring contact reduces PPA in mothers, however, parallel investigations in fathers has gone unaddressed. Adult neurogenesis in the dentate gyrus (DG) contributes to anxiety regulation and is altered during the postpartum period. Yet […]

Activation of medullary dorsal horn PKCγ Interneurons is essential to the development of both static and dynamic facial mechanical allodynia

Abstract The γ isoform of protein kinase C (PKCγ) which is concentrated in a specific class of interneurons within inner lamina II (IIi) of the spinal and medullary (MDH) dorsal horns is known to be involved in the development of mechanical allodynia, a widespread and intractable symptom of inflammatory or neuropathic pain. However, although genetic […]

Deciphering phonemes from syllables in BOLD signals in human superior temporal gyrus

Abstract Linguistic units such as phonemes and syllables are important for speech perception. How the brain encodes these units is not well understood. Many neuroimaging studies have found distinct representations of consonant-vowel (CV) syllables that shared one phoneme and differed in the other phoneme (e.g., /ba/ and /da/), but it is unclear whether this discrimination […]

Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55)

Summary Objective The aim of this study was to examine measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) across age, sex, and time in a representative sample of children with newly diagnosed epilepsy. Methods Data come from 373 children enrolled in the Health-related Quality of Life in Children with […]

The road to independence: how to get funding in neuroscience

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1UHXKrC via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RhaEyZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IXZmNn via IFTTT from #Med Blogs by Alexandros G.Sfakianakis […]

Podcast 165 – The Semantics of End of Life Discussions with Ashley Shreves

How to have an end of life conversation in the ED EMCrit by Scott Weingart. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1VX9MyL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UHtGwh via IFTTT from #Med Blogs by Alexandros […]

The synthetic progesterone ‘Norgestrel’ is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling

Abstract The synthetic progesterone ‘Norgestrel’, has been shown to have proven neuroprotective efficacy in two distinct models of Retinitis Pigmentosa: the rd10/rd10 (B6.CXBI-Pde6brd10/J) mouse model and the Balb/c light damage model. However, the cellular mechanism underlying this neuroprotection is still largely unknown. Therefore, this study aimed to examine the downstream signalling pathways associated with Norgestrel […]

Janet Jackson Battling Cancer?: Vocal Cord Tests Find Scary Growth — Report – Hollywood Life

Hollywood Life Janet Jackson Battling Cancer?: Vocal Cord Tests Find Scary Growth — Report Hollywood Life “God forbid that this should be cancer of the larynx. That would abruptly end her ability to ever perform again.” He explained that the surgery itself would be rough, as well as the further treatment. “Surgery would be very […]

Janet Jackson reportedly being treated for throat cancer – cleveland.com

cleveland.com Janet Jackson reportedly being treated for throat cancer cleveland.com Jackson also insisted all dates would be rescheduled. However, if Jackson indeed has cancer of the larynx, it would likely require surgery involving an artificial voice box, which could end her singing career. Jackson or anyone from her team has yet to … from #Head […]

The road to independence: how to get funding in neuroscience

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1UHXKrC via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RhaEyZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JEkzfh via IFTTT from #Med Blogs by Alexandros G.Sfakianakis […]

Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Abstract Amylin is a pancreatic β-cell hormone that acts as a satiating signal to inhibit food intake by binding to amylin receptors (AMY) and activating a specific neuronal population in the *area postrema* (AP). AMY are heterodimers that include a calcitonin receptor (CTR) subunit (CTRa or CTRb) and a member of the receptor activity modifying proteins (RAMPs). Here, we used single cell qPCR to assess co-expression of AMY subunits in AP neurons from rats that were injected with amylin or vehicle. Because amylin interacts synergistically with the adipokine leptin to reduce body we...περισσότερα »

Adult cortical plasticity: a murine model? (Commentary on Smolders et al.)

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Abstract The ability of neurons to undergo experience-dependent changes in form and function early in an organism's development is an area of intense research. The seminal studies of Hubel and Wiesel established the feline (Hubel and Wiesel, 1963) and later the macaque visual systems (Hubel et al., 1977) as premier animal models for investigating experienced-based neuroplasticity in developing animals. They demonstrated that the effects of visual deprivation on ocular dominance—a hallmark property of neurons in the early visual system—depend not only on the duration of deprivation,...περισσότερα »

Thyroid Cancer Survivors Have Gloomy Outlook In Life — Study – Science Times

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Science Times Thyroid Cancer Survivors Have Gloomy Outlook In Life — Study Science Times Thyroid cancer starts when the abnormal cells mount up on the thyroid gland of a person. This type of cancer is very treatable and has a higher survival rate than other cancer types. However, a recent study revealed that those people… Continue reading Thyroid Cancer Survivors Have Gloomy Outlook In Life — Study – Science Times

Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55)

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
[image: cover.gif?v=1&s=86d3aef2ad3355d25bd62fb1] Summary Objective The aim of this study was to examine measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) across age, sex, and time in a representative sample of children with newly diagnosed epilepsy. Methods Data come from 373 children enrolled in the Health-related Quality of Life in Children with Epilepsy Study (HERQULES), a multisite prospective cohort study. Measurement equivalence was examined using a multiple-group confirmatory factor analysis framework, whereby ... περισσότερα »

Up-regulation and axonal transport of synaptotagmin-IV in the direct pathway medium spiny neurons in hemi-parkinsonian rats induced by dopamine D1 receptor stimulation

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Abstract Synaptotagmin-IV may function as a regulator of Ca2+-dependent synaptic transmission. In hemi-parkinsonian rats with unilateral lesions of dopaminergic nigrostriatal neurons, synaptotagmin-IV and substance-P mRNAs could be up-regulated within the dopaminergically hypersensitive striatum of the lesioned brain hemisphere *via* the stimulation of striatal dopamine D1, but not D2 receptors. The hypersensitive D1 receptor-mediated transmission may be the culprit for the undesired expression of levodopa-induced dyskinesia, implying the involvement of synaptotagmin-IV and substa...περισσότερα »

ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Abstract Disturbance of homeostasis within the ER lumen leads to the accumulation of unfolded and misfolded proteins. This results in the activation of an evolutionary conserved stress response termed ER stress that, if unresolved, induces apoptosis. We previously identified the Bcl-2 homology domain 3 (BH3)-Only Protein Puma as a mediator of ER stress-induced apoptosis in neurons. In the search of alternative contributors to ER stress-induced apoptosis, we noted a downregulation of the anti-apoptotic Bcl-2 family protein Mcl-1 during ER stress in both mouse cortical neurons and h...περισσότερα »

Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Abstract Orexin (ORX, also known as hypocretin, HRCT) neurons are located exclusively in the posterior hypothalamus and are involved in a wide range of behaviors, including motivation for drugs of abuse such as alcohol. Hypothalamic subregions contain functionally distinct populations of ORX neurons that may play different roles in regulating drug- and alcohol-motivated behaviors. To investigate the role of ORX neurons in alcohol seeking, we measured Fos activation of ORX neurons in rats following three different measures of alcohol seeking and preference: 1) context-induced reins... περισσότερα »

Getting back on the beat: links between auditory-motor integration and precise auditory processing at fast time scales

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Abstract The auditory system is unique in its ability to precisely detect the timing of perceptual events and use this information to update motor plans, a skill crucial for language. The characteristics of the auditory system which enable this temporal precision, however, are only beginning to be understood. Previous work has shown that participants who can tap consistently to a metronome have neural responses to sound with greater phase coherence from trial to trial. We hypothesized that this relationship is driven by a link between the updating of motor output by auditory feedb... περισσότερα »

Deciphering phonemes from syllables in BOLD signals in human superior temporal gyrus

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Abstract Linguistic units such as phonemes and syllables are important for speech perception. How the brain encodes these units is not well understood. Many neuroimaging studies have found distinct representations of consonant-vowel (CV) syllables that shared one phoneme and differed in the other phoneme (e.g., /ba/ and /da/), but it is unclear whether this discrimination ability is due to the neural coding of phonemes or syllables. We combined functional magnetic resonance imaging (fMRI) with multivariate pattern analysis to explore this question. Subjects listened to nine mandari... περισσότερα »

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