Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Diffuse Idiopathic Skeletal Hyperostosis (DISH) – diagnostic, clinical and paleopathological considerations: Abstract Diffuse idiopathic skeletal hyperostosis is a disease primarily affecting the spine. However, it is also associated with the ossification/calcification of tendon, ligament and capsule insertions (entheses) occurring at multiple peripheral sites. The etiology of the condition is unknown, as the name suggests (diffuse *idiopathic* skeletal hyperostosis), although some correlations with diabetes mellitus, obesity and age have been noted. Clinical diagnostic criteria ha... περισσότερα »
The histomorphometric and histopathologic effect of methionine on the epidermis and dermis layers of skin in rat
The histomorphometric and histopathologic effect of methionine on the epidermis and dermis layers of skin in rat: AbstractThe skin is the largest organ of the body and is composed of epidermis (the outermost layer of cells consisting mainly of keratinized, stratified, squamous epithelium) and dermis (a layer of connective tissue composed of cells and fibrils such as collagen bundles). The aim of this study was to assess the effect of excess methionine on the histomorphology and histomorphometry of collagen bundles in these layers. Eighty, 9–10-week old, male rats were randomly allo... περισσότερα »
Severe Human Parechovirus Infections in Infants and the Role of Older Siblings
Severe Human Parechovirus Infections in Infants and the Role of Older Siblings: Human parechovirus (HPeV) is a cause of severe morbidity among infants and young children. To evaluate the associations between early environmental risk factors and HPeV infections, we carried out a nationwide cohort study linking registry data on birth and sibship characteristics with a laboratory surveillance database, covering all HPeV infections detected in Denmark during 2009–2012 among children <5 years of age. Incidence rate ratios were calculated in log-linear Poisson regression analyses. Overal... περισσότερα »
Airborne Pollen Concentrations and Myocardial Infarction
Airborne Pollen Concentrations and Emergency Room Visits for Myocardial Infarction: A Multicity Case-Crossover Study in Ontario, Canada: Few studies have examined the acute cardiovascular effects of airborne allergens. We conducted a case-crossover study to evaluate the relationship between airborne allergen concentrations and emergency room visits for myocardial infarction (MI) in Ontario, Canada. In total, 17,960 cases of MI were identified between the months of April and October during the years 2004–2011. Daily mean aeroallergen concentrations (pollen and mold spores) were assi...περισσότερα »
Hypertension and Arterial Stiffness
Invited Commentary: Hypertension and Arterial Stiffness--Origins Remain a Dilemma: In this issue of the *Journal*, Chen et al. (*Am J Epidemiol*. 2016;183(7):599–608) present repeated measures of aorto-femoral pulse wave velocity, capacitive compliance (*C*1), and oscillatory compliance (*C*2) in the Bogalusa Heart Study, with the purpose of addressing which comes first: blood pressure elevation or arterial stiffening. After an average follow-up period of 7 years (2000–2010), the authors found that blood pressure at a mean age of 36 years predicted change in arterial stiffening by... περισσότερα »
Prenatal Exposure to Nitrosatable Drugs, Dietary Intake of Nitrites, and Preterm Birth
Prenatal Exposure to Nitrosatable Drugs, Dietary Intake of Nitrites, and Preterm Birth: Prenatal exposure to nitrosatable drugs, including secondary or tertiary amines, has been associated with preterm birth. Associations may be accentuated by higher intakes of dietary nitrites because of the increased formation of *N*-nitroso compounds. Using data from mothers of babies without major birth defects (controls) from the National Birth Defects Prevention Study, we examined the relationship between nitrosatable drug exposure in conjunction with dietary nitrite intake and preterm birth ... περισσότερα »
Elevated Blood Pressure and Arterial Stiffening
Temporal Relationship Between Elevated Blood Pressure and Arterial Stiffening Among Middle-Aged Black and White Adults: The Bogalusa Heart Study: This study assessed the temporal relationship between elevated blood pressure (BP) and arterial stiffness in a biracial (black-white) cohort of middle-aged adults aged 32–51 years from the semirural community of Bogalusa, Louisiana. Measurements of aortic-femoral pulse wave velocity (afPWV; *n* = 446) and large- and small-arterial compliance (*n* = 381) were obtained at 2 time points between 2000 and 2010, with an average follow-up perio...περισσότερα »
The Natural History of Human Polyomaviruses and Herpesviruses in Early Life--The Rhea Birth Cohort in Greece
The Natural History of Human Polyomaviruses and Herpesviruses in Early Life--The Rhea Birth Cohort in Greece: Sparse data exist on the patterns and determinants of acquisition of polyomaviruses and herpesviruses in childhood. We measured immunoglobulin G seroreactivity against 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, HPyV10) and 5 herpesviruses (Epstein Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus types 1 and 2, human herpesvirus 8) using multiplex serology on blood samples collected at birth (cord blood, *n* = 626) and at f... περισσότερα »
Advances in personalized cancer immunotherapy
Advances in personalized cancer immunotherapy: AbstractThere are currently three major approaches to T cell-based cancer immunotherapy, namely, active vaccination, adoptive cell transfer therapy and immune checkpoint blockade. Recently, this latter approach has demonstrated remarkable clinical benefits, putting cancer immunotherapy under the spotlight. Better understanding of the dynamics of anti-tumor immune responses (the “Cancer-Immunity Cycle”) is crucial for the further development of this form of treatment. Tumors employ multiple strategies to escape from anti-tumor immunity,...περισσότερα »
Prognostic value of glucosylceramide synthase and P-glycoprotein expression in oral cavity cancer
Prognostic value of glucosylceramide synthase and P-glycoprotein expression in oral cavity cancer: Abstract BackgroundGlucosylceramide synthase (GCS) and P-glycoprotein (P-gp) overexpression are associated with multidrug resistance in several human cancers. This study investigated the prognostic value of GCS and P-gp in oral cavity squamous cell carcinoma (OSCC). MethodsThe association between GCS and P-gp overexpression and clinical outcomes was assessed in 186 human clinical specimens of primary tumors obtained from curative surgery. Immunohistochemistry staining results were... περισσότερα »
Functional activation of PPARγ in human upper aerodigestive cancer cell lines
Functional activation of PPARγ in human upper aerodigestive cancer cell lines: Upper aerodigestive cancer is an aggressive malignancy with relatively stagnant long-term survival rates over 20 yr. Recent studies have demonstrated that exploitation of PPARγ pathways may be a novel therapy for cancer and its prevention. We tested whether PPARγ is expressed and inducible in aerodigestive carcinoma cells and whether it is present in human upper aerodigestive tumors. Human oral cancer CA-9-22 and NA cell lines were treated with the PPAR activators eicosatetraynoic acid (ETYA), 15-deoxy-...περισσότερα »
SOXC And MiR17-92 Gene Expression Profiling Defines Two Subgroups With Different Clinical Outcome In Mantle Cell Lymphoma
SOXC And MiR17-92 Gene Expression Profiling Defines Two Subgroups With Different Clinical Outcome In Mantle Cell Lymphoma: ABSTRACT Mantle cell lymphoma (MCL) is an heterogeneous B-cell lymphoid malignancy where most patients follow an aggressive clinical course whereas others are associated with an indolent performance. *SOX4*, *SOX11* and *SOX12* belong to *SOXC* family of transcription factors involved in embryonic neurogen esis and tissue remodeling. Among them, *SOX11* has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in... περισσότερα »
Management of immune checkpoint blockade dysimmune toxicities
Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper: Monoclonal antibodies targeted against the immune checkpoint molecules CTLA-4 and PD-1 have recently obtained approval for the treatment of metastatic melanoma and advanced/refractory non small-cell lung cancers. Therefore, their use will not be limited anymore to selected hospitals involved in clinical trials. Indeed, they will be routinely prescribed in many cancer centers across the world. Besides their efficacy profile, these immune targeted agents also generate immune-related adverse... περισσότερα »
Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab
Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab: Background Clinical responses to ipilimumab are variable in terms of onset, magnitude and duration. Upfront identification of patients who are more likely or unlikely to benefit from treatment is a major need. Patients and methods Prospectively collected data from 720 advanced melanoma patients treated with ipilimumab 3 mg/kg within the Italian expanded access program were analyzed. The derived neutrophil-to-lymphocyte ratio (dNLR) was calculate...περισσότερα »
Everolimus (RAD001), an mTOR inhibitor plus CHOP for newly diagnosed peripheral T-cell lymphomas
A phase II study of everolimus (RAD001), an mTOR inhibitor plus CHOP for newly diagnosed peripheral T-cell lymphomas: Background Everolimus, an oral mTOR inhibitor, has single-agent activity against relapsed lymphomas. Thus, we carried out a phase II study of everolimus in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) as a first-line treatment for patients with peripheral T-cell lymphoma (PTCL) based on our phase I study results. Patients and methods Participants (*n* = 30) received CHOP with 5 mg everolimus per day from day 1 to 14 every 21 day... περισσότερα »
Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein [Melanoma]
Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein [Melanoma]: Purpose To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement. Materials and Methods Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were de... περισσότερα »
Treatment Modalities and Outcomes in Patients With Advanced Invasive Thymoma or Thymic Carcinoma: A Retrospective Multicenter Study
Treatment Modalities and Outcomes in Patients With Advanced Invasive Thymoma or Thymic Carcinoma: A Retrospective Multicenter Study: Abstract Introduction: We investigated the relationships between treatment characteristics and long-term outcomes in patients with locally advanced thymoma or thymic carcinoma. Methods: We retrospectively reviewed 146 patients treated from 1980 to 2011 at 2 tertiary cancer care centers, 110 with Masaoka-Koga stages III to IVA invasive thymoma and 36 with stages I to IVA thymic carcinoma. Survival probabilities were estimated using the Kaplan-Meier met...περισσότερα »
Induction Therapy for Locally Advanced, Resectable Esophagogastric Cancer: A Phase I Trial of Vandetanib (ZD6474), Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiotherapy Followed by Resection.
Induction Therapy for Locally Advanced, Resectable Esophagogastric Cancer: A Phase I Trial of Vandetanib (ZD6474), Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiotherapy Followed by Resection.: Objectives: Preoperative chemotherapy and radiation for localized esophageal cancer produces cure rates near 30% when combined with surgical resection. Vandetanib, a small molecule receptor tyrosine kinase inhibitor of VEGFR-2, VEGFR-3, RET, and EGFR, demonstrated synergy with radiation and chemotherapy in preclinical models. We conducted a phase I study to assess the safety and tolerabili... περισσότερα »
Hair dye use, regular exercise, and the risk and prognosis of cancer
Hair dye use, regular exercise, and the risk and prognosis of prostate cancer: multicenter case–control and case-only studies: Abstract BackgroundThis study investigated the effects that hair dye use and regular exercise exert on the risk and prognosis of prostate cancer. MethodsWe studied 296 cases of histologically confirmed prostate cancer and 296 age- (in 2-y bands), ethnicity-, and hospital-matched controls in Taiwan between August 2000 and December 2008. To determine the rate of prostate cancer survival, another 608 incident prostate cancer cases occurring between August ... περισσότερα »
Tumour seeding in the surgical pathway after resection of skull base chordoma
Tumour seeding in the surgical pathway after resection of skull base chordoma via Reports of Practical Oncology & Radiotherapy Publication date: Available online 21 March 2016 *Source:*Reports of Practical Oncology & Radiotherapy Author(s): Marco Krengli, Arturo Poletti, Eleonora Ferrara, Piero Fossati AimThe aim of this study is to review the clinical series in which tumour seeding was reported after skull base surgery for chordomas.BackgroundThe occurrence of implantation of cancer cells during surgical procedures for the removal of chordoma is a rare event described by a number of au... περισσότερα »
Bleomycin pharmacokinetics of bolus bleomycin dose in elderly cancer patients treated with electrochemotherapy
Bleomycin pharmacokinetics of bolus bleomycin dose in elderly cancer patients treated with electrochemotherapy: Abstract PurposeWith the aim to determine effective therapeutic window of electrochemotherapy, we analyzed bleomycin pharmacokinetic parameters in elderly patients. MethodsIn prospective clinical study in the treatment of tumors with electrochemotherapy, blood samples of patients older than 65 years were collected after the bolus intravenous injection of bleomycin (15,000 IU/m2). In serum samples, quantitative analysis was performed with liquid chromatography coupled...περισσότερα »
Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers
Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers: Abstract BackgroundThe aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery. MethodsFour hu3S193 variants (I253A, H310A, H435A and I253A/H310A) were generated via site-directed mutagenesis and radiolabelled with diagnostic isotopes iodine-125 or indium-111. Biodistribution studies in Lewis-Y-positive tumour-bearing mice were used to calcul... περισσότερα »
Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial
Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial: Abstract BackgroundTo compare the effects of resistance training versus passive physical therapy on bone turnover markers (BTM) in the metastatic bone during radiation therapy (RT) in patients with spinal bone metastases. Secondly, to evaluate an association of BTM to local response, skeletal-related events (SRE), and number of metastases. MethodsIn this randomized trial, 60 patients were allocated from September 2011 to March 2013 into one ... περισσότερα »
Prognostic value of perihematomal edema area at the initial ED presentation in patients with intracranial hematoma
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ShgEWo via IFTTT
Occupational stress experienced by residents and faculty physicians on night shifts
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1VDRSCP via IFTTT
Influence of thyroid hormone therapy on the fracture rate — A claims data cohort study
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Vertebral osteomyelitis caused by non-tuberculous mycobacteria: Predisposing conditions and clinical characteristics of six cases and a review of 63 cases in the literature
10.3109/23744235.2016.1158418<br>Chung-Jong Kim from Infection via ola Kala on Inoreader http://ift.tt/1RkslZY via IFTTT
Mastocytosis in adulthood and neuropsychiatric disorders
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Publication date: Available online 22 March 2016 Source:Translational Research Author(s): Sophie Georgin-Lavialle, Raphaël Gaillard, Daniela Moura, Olivier Hermine Patients with mastocytosis can display various disabling general and neuropsychological symptoms among one third of them, including general signs such as fatigue and musculoskeletal pain which can have a major impact on quality of life. Neurological symptoms […]
CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma
CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma: Abstract BackgroundIn previous investigation, we reported that stably knocking down cyclin-dependent kinase 4(CDK4) induced expression of let-7c, which further suppressed cell cycle transition and cell growth by modulating cell cycle signaling in nasopharyngeal carcinoma (NPC). In this study, we further explored the molecular function and mechanism of CDK4 modulating miRNAs to stimulate cell cycle transition, cell growth,... περισσότερα »
Three-dimensional customized bolus for intensity-modulated radiotherapy
Three-dimensional customized bolus for intensity-modulated radiotherapy in a patient with Kimura's disease involving the auricle via Cancer/Radiothérapie Publication date: Available online 22 March 2016 *Source:*Cancer/Radiothérapie Author(s): J.W. Park, J.W. Yea In radiotherapy, a commercial bolus often does not provide a suitable fit over irregular surfaces. To address this issue, we fabricated a customized bolus using 3D printing technology. The aim of our study was to evaluate the application of this 3D-printed bolus in a clinical setting. The patient was a 45-year-old man with rec... περισσότερα »
Kimura's disease involving the auricle
Three-dimensional customized bolus for intensity-modulated radiotherapy in a patient with Kimura's disease involving the auricle via Cancer/Radiothérapie Publication date: Available online 22 March 2016 *Source:*Cancer/Radiothérapie Author(s): J.W. Park, J.W. Yea In radiotherapy, a commercial bolus often does not provide a suitable fit over irregular surfaces. To address this issue, we fabricated a customized bolus using 3D printing technology. The aim of our study was to evaluate the application of this 3D-printed bolus in a clinical setting. The patient was a 45-year-old man with rec... περισσότερα »
Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma—a propensity score matched study
Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma—a propensity score matched study: Abstract PurposeTo compare the long-term outcomes in patients with salivary gland adenoid cystic carcinoma (SGACC) treated with post-operative chemoradiotherapy (POCRT) *versus* post-operative radiotherapy (PORT). MethodsWe retrospectively reviewed the records of 91 SGACC patients treated with surgery followed by PORT (*n* = 58) or POCRT (*n* = 33) between 2000 and 2013. Tre...περισσότερα »
Total body irradiation with volumetric modulated arc therapy
Total body irradiation with volumetric modulated arc therapy: Dosimetric data and first clinical experience: Abstract BackgroundTo implement total body irradiation (TBI) using volumetric modulated arc therapy (VMAT). We applied the Varian RapidArc™ software to calculate and optimize the dose distribution. Emphasis was placed on applying a homogenous dose to the PTV and on reducing the dose to the lungs. MethodsFrom July 2013 to July 2014 seven patients with leukaemia were planned and treated with a VMAT-based TBI-technique with photon energy of 6 MV. The overall planning target...περισσότερα »
Alveolar rhabdomyosarcoma mimicking Burkitt-like lymphoma
Alveolar rhabdomyosarcoma mimicking Burkitt-like lymphoma:
Human papillomavirus antibodies in individuals with head and neck cancer
Characterization of via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: June 2016 *Source:*Cancer Epidemiology, Volume 42 Author(s): Krystle A. Lang Kuhs, Michael Pawlita, Sandra P. Gibson, Nicole C. Schmitt, Sumita Trivedi, Athanassios Argiris, Aimée R. Kreimer, Robert L. Ferris, Tim Waterboer BackgroundHuman papillomavirus type 16 (HPV16) E6 antibodies are a promising biomarker of oropharyngeal cancer (OPC); however, seropositivity among non-OPC cases is not well characterized.MethodsPre-treatment sera from 260 (38 OPC, 222 non-OPC) incident head and n... περισσότερα »
HPV16 (L1,E1,E2,E4,E6,E7) and non-HPV16 E6 (HPV6,11,18,33) antibodies
Characterization of human papillomavirus antibodies in individuals with head and neck cancer via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: June 2016 *Source:*Cancer Epidemiology, Volume 42 Author(s): Krystle A. Lang Kuhs, Michael Pawlita, Sandra P. Gibson, Nicole C. Schmitt, Sumita Trivedi, Athanassios Argiris, Aimée R. Kreimer, Robert L. Ferris, Tim Waterboer BackgroundHuman papillomavirus type 16 (HPV16) E6 antibodies are a promising biomarker of oropharyngeal cancer (OPC); however, seropositivity among non-OPC cases is not well characterized.Meth...περισσότερα »
Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil
Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil: Abstract BackgroundSmoking and betel nut chewing are well-known risk factors for head and neck squamous cell carcinoma (HNSCC). Smoking is also a strong prognosticator for patients with locally advanced HNSCC receiving induction chemotherapy. Smoking with or without betel nut chewing is a common practice in Asia. However, little is known regarding whether be... περισσότερα »
Whole-body simultaneous PET/MRI in pediatric
Evaluation of diagnostic performance of whole-body simultaneous PET/MRI in pediatric lymphoma: Abstract BackgroundWhole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is the standard of care for lymphoma. Simultaneous PET/MRI (magnetic resonance imaging) is a promising new modality that combines the metabolic information of PET with superior soft-tissue resolution and functional imaging capabilities of MRI while decreasing radiation dose. There is limited information on the clinical performance of PET/MRI in the pediatric setting. O... περισσότερα »
Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy
Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy: AbstractAutophagy is a highly conserved lysosome-dependent degradation process that may digest some long-lived proteins and damaged organelles. As an essential homeostasis maintaining system in normal cells, autophagy plays a key role in several pathological settings, especially cancer. Metastasis, known as a crucial hallmark of cancer progression, is the primary cause of cancer lethality. The role of autophagy in metastasis is quite complex as supportive evidence has indicated both pro-m... περισσότερα »
Severe Thrombocytopenia as Initial Signs of Primary Sjögren Syndrome in a 9-Year-Old Female
Severe Thrombocytopenia as Initial Signs of Primary Sjögren Syndrome in a 9-Year-Old Female: [image: cover.gif?v=1&s=71a143ea4673582f5241d4f5]
Pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced solid tumors
Phase 1 study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced solid tumors: Summary*Background* This phase I study evaluated the safety and tolerability, pharmacokinetics and pharmacodynamics, immunogenicity, and antitumor activity of pembrolizumab in Japanese patients with advanced solid tumors. *Methods* Following an initial dose and a 28-day rest (cycle 1), pembrolizumab was administered as an intravenous infusion at escalating doses (2 or 10 mg/kg) every 2 weeks (Q2W) until disease progression or unacceptable toxicity. Adverse events... περισσότερα »
American cancer society head and neck cancer survivorship care guideline
American cancer society head and neck cancer survivorship care guideline: Answer questions and earn CME/CNE The American Cancer Society Head and Neck Cancer Survivorship Care Guideline was developed to assist primary care clinicians and other health practitioners with the care of head and neck cancer survivors, including monitoring for recurrence, screening for second primary cancers, assessment and management of long-term and late effects, health promotion, and care coordination. A systematic review of the literature was conducted using PubMed through April 2015, and a multidiscipl... περισσότερα »
Anti-cancer electrochemotherapy with immunotherapy
The promising alliance of anti-cancer electrochemotherapy with immunotherapy: AbstractAnti-tumor electrochemotherapy, which consists in increasing anti-cancer drug uptake by means of electroporation, is now implanted in about 140 cancer treatment centers in Europe. Its use is supported by the English National Institute for Health and Care Excellence for the palliative treatment of skin metastases, and about 13,000 cancer patients were treated by this technology by the end of 2015. Efforts are now focused on turning this local anti-tumor treatment into a systemic one. Electrogeneth... περισσότερα »
Healthy Skin: Cancer Education for School Teachers and Nurses Using a “Train and Equip” Method
Healthy Skin: Cancer Education for School Teachers and Nurses Using a “Train and Equip” Method: AbstractSkin cancer, especially malignant melanoma, continues on the increase. Different interventions are attempting to impact on this problem. The approach used by the Partners in Health Sciences program at the University of Arkansas for Medical Science is to both “train” and, importantly, “equip” classroom teachers and school nurses in a “Healthy Skin” professional development curriculum. Each participant not only received face-to-face interactive content training in a workshop settin... περισσότερα »
Caring touch as a bodily anchor for patients after sustaining a motor vehicle accident with minor or no physical injuries – a mixed methods study
Abstract Background Patients who sustain a motor vehicle accident may experience long-term distress, even if they are uninjured or only slightly injured. There is a risk of neglecting patients with minor or no physical injuries, which might impact future health problems. The aim of this study was to explore patients’ subjective experiences and perspectives on… Continue reading Caring touch as a bodily anchor for patients after sustaining a motor vehicle accident with minor or no physical injuries – a mixed methods study
Understanding Outliers and Defining Value in Neonatal Healthcare
Publication date: Available online 22 March 2016 Source:The Journal of Pediatrics Author(s): Reese H. Clark, Alan R. Spitzer from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o64UeF via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/25m24E0 via IFTTT
Chilaiditi Syndrome
Publication date: Available online 22 March 2016 Source:The Journal of Pediatrics Author(s): Havva Evrengül, Selçuk Yüksel, Seda Orpak, Bayram Özhan, Kadir Ağladıoğlu from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ukb0qf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UFtl0y via… Continue reading Chilaiditi Syndrome
It’s time for cancer classification to take centre stage! https://t.co/LKKGbbbfsV https://t.co/AyGfDydYwZ
It’s time for cancer classification to take centre stage! https://t.co/LKKGbbbfsV https://t.co/AyGfDydYwZ from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/712594846343634944 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XMo0ma via IFTTT
Effectiveness of centre-based childcare interventions in increasing child physical activity: a systematic review and meta-analysis for policymakers and practitioners
Summary Context The review describes the effectiveness of physical activity interventions implemented in centre-based childcare services and (i) examines characteristics of interventions that may influence intervention effects; (ii) describes the effects of pragmatic interventions and non-pragmatic interventions; (iii) assesses adverse effects; and (iv) describes cost-effectiveness of interventions Methods Data sources were Cochrane Central Register of… Continue reading Effectiveness of centre-based childcare interventions in increasing child physical activity: a systematic review a... περισσότερα »
Is There a Hidden Link Between Thyroid Cancer and Breast Cancer? – Newsmax
Is There a Hidden Link Between Thyroid Cancer and Breast Cancer? Newsmax The researchers found that those patients who had been previously treated and survived thyroid cancer had a slightly higher risk of developing another cancer, unrelated to the thyroid, within the first 10 years. After 10 years, the risk was not higher … from… Continue reading Is There a Hidden Link Between Thyroid Cancer and Breast Cancer? – Newsmax
What can Europe learn from the managed care backlash in the United States?
Publication date: Available online 22 March 2016 Source:Health Policy Author(s): Daniëlle M.I.D. Duijmelinck, Wynand P.M.M. van de Ven Germany, the Netherlands, and Switzerland have taken steps towards regulated competition on the health insurance market to enhance efficiency and consumer responsiveness. The rationale of giving the consumer a periodic choice of health insurer is that individual… Continue reading What can Europe learn from the managed care backlash in the United States?
Speciated High-Density Lipoprotein Biogenesis and Functionality
Abstract Plasma high-density lipoprotein cholesterol (HDL-C) concentration is a negative risk factor for atherosclerotic cardiovascular disease (CVD). Despite this, most attempts to raise plasma HDL-C concentrations in a cardioprotective way have failed. Recently, hypotheses about the atheroprotective effects of HDL have shifted away from quantity to quality, mostly HDL function in reverse cholesterol transport. Plasma… Continue reading Speciated High-Density Lipoprotein Biogenesis and Functionality
Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions
Abstract Historically, the relationship between exercise and the cardiovascular system was viewed as unidirectional, with a disease resulting in exercise limitation and hazard. This article reviews and explores the bidirectional nature, delineating the effects, generally positive, on the cardiovascular system and atherosclerosis. Exercise augments eNOS, affects redox potential, and favorably affects mediators of atherosclerosis including… Continue reading Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions
Unravelling the relationship between macroautophagy and mitochondrial ROS in cancer therapy
Abstract Macroautophagy (Autophagy), an evolutionarily conserved cellular self-digesting process implicated in various physiological and pathological processes, is activated by different stimuli including oxidative stress. Reactive oxygen species (ROS) are involved in autophagy modulation through multiple signaling pathways and transcription regulators. Accumulating data support both a positive and negative role of ROS-modulated autophagy in cancer. As… Continue reading Unravelling the relationship between macroautophagy and mitochondrial ROS in cancer therapy
68Ga-Prostate specific membrane antigen- N,N′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT
Unusual Uptake of Prostate Specific Tracer 68 Ga-PSMA–HBED-CC in a Benign Thyroid Nodule: Abstract68Ga-Prostate specific membrane antigen- *N,N′* -bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-*N,N′*-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncert... περισσότερα »
Unusual Uptake of Prostate Specific Tracer 68 Ga-PSMA–HBED-CC in a Benign Thyroid Nodule
Unusual Uptake of Prostate Specific Tracer 68 Ga-PSMA–HBED-CC in a Benign Thyroid Nodule: Abstract68Ga-Prostate specific membrane antigen- *N,N′* -bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-*N,N′*-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncert... περισσότερα »
Total body irradiation with volumetric modulated arc therapy
Total body irradiation with volumetric modulated arc therapy: Dosimetric data and first clinical experience: Abstract Background To implement total body irradiation (TBI) using volumetric modulated arc therapy (VMAT). We applied the Varian RapidArc™ software to calculate and optimize the dose distribution. Emphasis was placed on applying a homogenous dose to the PTV and on reducing the dose to the lungs. Methods From July 2013 to July 2014 seven patients with leukaemia were planned and treated with a VMAT-based TBI-technique with photon energy of 6 MV. The overall plannin... περισσότερα »
Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma—a propensity score matched study
Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma—a propensity score matched study: To compare the long-term outcomes in patients with salivary gland adenoid cystic carcinoma (SGACC) treated with post-operative chemoradiotherapy (POCRT) versus post-operative radiotherapy (PORT). Cheng-En Hsieh, Chien-Yu Lin†, Li-Yu Lee, Lan-Yan Yang, Chun-Chieh Wang, Hung-Ming Wang, Joseph Tung-Chieh Chang, Kang-Hsing Fan, Chun-Ta Liao, Tzu-Chen Yen, Ku-Hao Fang and Yan-Min... περισσότερα »
Non-genetic health professionals’ attitude towards, knowledge of and skills in discussing and ordering genetic testing for hereditary cancer
Non-genetic health professionals’ attitude towards, knowledge of and skills in discussing and ordering genetic testing for hereditary cancer: AbstractNon-genetic health professionals (NGHPs) have insufficient knowledge of cancer genetics, express educational needs and are unprepared to counsel their patients regarding their genetic test results. So far, it is unclear how NGHPs perceive *their* own communication skills. This study was undertaken to gain insight in their perceptions, attitudes and knowledge. Two publically accessible databases were used to invite NGHPs providing canc...περισσότερα »
A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking
A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking: [image: gr1.sml] A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion.
The cavernous sinus in cluster headache - a quantitative structural magnetic resonance imaging study
Background It has been hypothesized that a constitutionally narrow cavernous sinus might predispose individuals to cluster headache. Cavernous sinus dimensions, however, have never been assessed. Methods In this case–control study, we measured the dimensions of the cavernous sinus, skull base, internal carotid and pituitary gland with high-resolution T2-weighted magnetic resonance imaging in 25 episodic, 24 chronic and 13 probable cluster headache patients, 8 chronic paroxysmal hemicrania patients and 22 headache-free controls. Dimensions were compared between groups, correcting ...περισσότερα »
Light can image premature babies' lungs
Laser light can be used to image premature babies' lungs as an alternative... Read more on AuntMinnieEurope.com Related Reading: MRI accurately pinpoints tubal pregnancy Get savvy on neonatal chest x-rays Belgian hospital reviews CT dose in pregnant patients Postmortem MRI measures up for fetal autopsy MRI provides answers on fetal facial clefts from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RjmOoI via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VDqh4J via IFTTT
MRI unravels neuro complications of Zika virus
[image: 2016_03_22_11_56_21_105_mosquito_zika_20]French experts have urged all clinical staff to keep aware that meningoencephalitis... Read more on AuntMinnieEurope.com from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/25lu6zE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MBDjZ5 via IFTTT
Abnormal tyrosine metabolism in chronic cluster headache
Objective Episodic cluster headache is characterized by abnormalities in tyrosine metabolism (i.e. elevated levels of dopamine, tyramine, octopamine and synephrine and low levels of noradrenalin in plasma and platelets.) It is unknown, however, if such biochemical anomalies are present and/or constitute a predisposing factor in chronic cluster headache. To test this hypothesis, we measured the levels of dopamine and noradrenaline together with those of elusive amines, such as tyramine, octopamine and synephrine, in plasma of chronic cluster patients and control individuals. Methods... περισσότερα »
Invasive pericranial nerve interventions
Background In many patients suffering from primary headaches, the available pharmacological and behavioural treatments are not satisfactory. This is a review of (minimally) invasive interventions targeting pericranial nerves that could be effective in refractory patients. Methods The interventions we will cover have in common pericranial nerves as targets, but are distinct according to their rationale, modality and invasiveness. They range from nerve blocks/infiltrations to the percutaneous implantation of neurostimulators and surgical decompression procedures. We have critically... περισσότερα »
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Issue Information – TOC
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Why are there apes? Evidence for the co-evolution of ape and monkey ecomorphology
Abstract Apes, members of the superfamily Hominoidea, possess a distinctive suite of anatomical and behavioral characters which appear to have evolved relatively late and relatively independently. The timing of paleontological events, extant cercopithecine and hominoid ecomorphology and other evidence suggests that many distinctive ape features evolved to facilitate harvesting ripe fruits among compliant terminal branches in tree edges. Precarious, unpredictably oriented, compliant supports in the canopy periphery require apes to maneuver using suspensory and non-sterotypical postu...περισσότερα »
TDG shows antitumor activity by β-GBP and Treg inhibition in oral squamous cell carcinoma
AbstractObjective Thiodigalactoside (TDG), a synthetic inhibitor of *β*-GBP that suppresses tumour growth by inhibiting multiple cancer enhancing activities of *β*-GBP. Hence, we attempted to understand if disruption of *β*-GBP functions and indirect inhibition of Treg cells by TDG affect the growth and establishment of oral cancer cells. Method The growth, morphology, cell cycle regulation, apoptosis induction and angiogenesis of oral cancer cell lines (SCC-4, SCC-9, SCC-25) via MACS purified Treg cells was performed by MTT, propidium iodide (PI) staining, annexin V-binding assay ... περισσότερα »
Cancers, Vol. 8, Pages 39: NORE1A Regulates MDM2 Via β-TrCP
Mouse Double Minute 2 Homolog (MDM2) is a key negative regulator of the master tumor suppressor p53. MDM2 regulates p53 on multiple levels, including acting as an ubiquitin ligase for the protein, thereby promoting its degradation by the proteasome. MDM2 is oncogenic and is frequently found to be over-expressed in human tumors, suggesting its dysregulation plays an important role in human cancers. We have recently found that the Ras effector and RASSF (Ras Association Domain Family) family member RASSF5/NORE1A enhances the levels of nuclear p53. We have also found that NORE1A (Nov... περισσότερα »
Benchmarking Radiation TherapisT (RTT) education for safe practice
Benchmarking Radiation TherapisT (RTT) education for safe practice: The time is now: For many years Radiation TherapisTs (RTTs) have endeavoured to attain professional recognition specific to their discipline, at an international level. Professional recognition encompasses the provision of defined education programmes underpinning graduate competence. The changing face of radiation oncology with increasingly complex treatment approaches is now, more than ever, dependent on an appropriately educated, competent workforce to ensure accurate preparation and delivery of treatment within a...περισσότερα »
Radiation Therapy Basics
You Ask, We Answer: Radiation Therapy Basics: *By Jacqueline Brown, MSN, OCN, CBCN* [image: Man Receiving Radiation Therapy for Cancer] As an oncology nurse information specialist at the American Cancer Society, part of my job is to help answer patients’ questions through our free 24-hour cancer information service. Many patients and caregivers call us with questions about treatment – including radiation therapy. When it comes to radiation, there are 4 questions in particular that seem to be the most common. As part of our new “You Ask, We Answer” series, I’ll give you answers ... περισσότερα »
Comparison of Miller and Airtraq laryngoscopes for orotracheal intubation by physicians wearing CBRN protective equipment during infant resuscitation: a randomized crossover simulation study
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1VDRTqe
Caring touch as a bodily anchor for patients after sustaining a motor vehicle accident with minor or no physical injuries - a mixed methods study
BMC Complementary and Alternative Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ShgGNT
Distribution and predictors of emergency department charges: The case of a tertiary hospital in Lebanon
BMC Health Services Research from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1VDRT9M
Gastric perforation following intragastric balloon insertion: combined endoscopic and laparoscopic approach for management: Case series and review of literature
Obesity Surgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ShgFcY
Processing of alcohol-related health threat in at-risk drinkers: An online study of gender-related self-affirmation effects
Alcohol and Alcoholism from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1VDRTGO
Management of cases of blunt trauma abdomen at the peripheral health care facility level--a suggested protocol
Journal of Health Management from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ShgDSk
Renal resistive index by transesophageal and transparietal echo-doppler imaging for the prediction of acute kidney injury in patients undergoing major heart surgery
Journal of Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1VDRQLb
Psychiatric illness is common among patients with orthopaedic polytrauma and is linked with poor outcomes
The Journal of Bone & Joint Surgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ShgDSa
Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights
Journal of Gastroenterology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1VDRQuF
Prognostic value of perihematomal edema area at the initial ED presentation in patients with intracranial hematoma
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ShgEWo
Occupational stress experienced by residents and faculty physicians on night shifts
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1VDRSCP
Influence of thyroid hormone therapy on the fracture rate — A claims data cohort study
Bone from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ShgEWg
Neurosurgical management of nonmissile penetrating cranial lesions
World Neurosurgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1VDRSmd
Severe Hypoglycemia in the Look AHEAD Trial
Journal of Diabetes and its Complications from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ShgDBC
Do crushed prasugrel tablets speed drug absorption in STEMI patients undergoing PPCI?
American College of Cardiology News from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/21GQjUb
PulmCrit- Update on post-extubation high-flow nasal cannula to reduce reintubation
[image: opener.gif?resize=750%2C221] Post-extubation HFNC has helped us aggressively liberate patients from mechanical ventilation while simultaneously reducing our reintubation rate. One remaining question is determining which patients benefit from this. My practice has generally been to use HFNC in patients felt to be at higher risk for reintubation. A fresh RCT in JAMA will revise this. EMCrit by Josh Farkas. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1o60Xqd
Radiation-induced translational control of gene expression
Radiation-induced translational control of gene expression: Changes in polysome-bound mRNA (translatome) are correlated closely with changes in the proteome in cells. Therefore, to better understand the processes mediating the response of glioblastoma (GBM) to ionizing radiation (IR), we used polysome profiling to define the IR-induced translatomes of a set of human glioblastoma stem-like cell (GSC) lines. Whereas cell line specificity accounted for the largest proportion of genes within each translatome, there were also genes that were common to the GSC lines. In particular, analys... περισσότερα »
Does the modified Glasgow Prognostic Score (mGPS) have a prognostic role in esophageal cancer?
Does the modified Glasgow Prognostic Score (mGPS) have a prognostic role in esophageal cancer?: Background The modified Glasgow Prognostic Score (mGPS), which combines indices of decreased plasma albumin and elevated CRP, has reported independent prognostic significance in colorectal cancer, but its value in upper gastrointestinal cancer is unclear. The aim of this study was to assess the prognostic significance of mGPS in patients with operable esophageal malignancy. Methods Patients undergoing resection with curative intent between January 2008 and June 2013 were included. The mG...περισσότερα »
Prognostic factors and disease-specific survival among immigrants diagnosed with cutaneous malignant melanoma in Sweden
Prognostic factors and disease-specific survival among immigrants diagnosed with cutaneous malignant melanoma in Sweden: Abstract Little is known about cutaneous malignant melanoma (CMM) among immigrants in Europe. We aimed to investigate clinical characteristics and disease-specific survival among first- and second-generation immigrants in Sweden This nationwide population-based study included 27,235 patients from the Swedish Melanoma Register diagnosed with primary invasive CMM 1990-2007. Data were linked to nationwide, population-based registers followed up through 2013. Logisti... περισσότερα »
Preferential Tumor Cellular Uptake and Retention of Indocyanine Green for In Vivo Tumor Imaging
Preferential Tumor Cellular Uptake and Retention of Indocyanine Green for In Vivo Tumor Imaging: Abstract Indocyanine green (ICG) is a fluorescent agent approved for clinical applications by the Food and Drug Administration and European Medicines Agency. This study examined the mechanism of tumor imaging using intravenously administered ICG. The *in vivo* kinetics of intravenously administered ICG were determined in tumor xenografts using microscopic approaches that enabled both spatio-temporal and high-magnification analyses. The mechanism of ICG-based tumor imaging was examined a... περισσότερα »
Cancer Drugs Fund 2.0: A Missed Opportunity?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RfVSaN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Caring touch as a bodily anchor for patients after sustaining a motor vehicle accident with minor or no physical injuries – a mixed methods study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Abstract Background Patients who sustain a motor vehicle accident may experience long-term distress, even if they are uninjured or only slightly injured. There is a risk of neglecting patients with minor or no physical injuries, which might impact future health problems. The aim of this study was to explore patients’ subjective experiences and perspectives on […]
Understanding Outliers and Defining Value in Neonatal Healthcare
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Publication date: Available online 22 March 2016 Source:The Journal of Pediatrics Author(s): Reese H. Clark, Alan R. Spitzer from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o64UeF via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Chilaiditi Syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Publication date: Available online 22 March 2016 Source:The Journal of Pediatrics Author(s): Havva Evrengül, Selçuk Yüksel, Seda Orpak, Bayram Özhan, Kadir Ağladıoğlu from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ukb0qf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Success of transdisciplinary science requires monodisciplinary support
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22ESgTj via IFTTT
Calcium waves in the brain alleviate depressive behavior in mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Researchers at the RIKEN Brain Science Institute in Japan have discovered that the benefits of stimulating the brain with direct current come from its effects on astrocytes — not neurons — in the… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MBQ8m6 via IFTTT
Editorial Board
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Publication date: 1 April 2016 Source:Nitric Oxide, Volume 54 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/25lZWMA via IFTTT
Genes, Vol. 7, Pages 12: De Novo Transcriptome Sequencing of Desert Herbaceous Achnatherum splendens (Achnatherum) Seedlings and Identification of Salt Tolerance Genes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Achnatherum splendens is an important forage herb in Northwestern China. It has a high tolerance to salinity and is, thus, considered one of the most important constructive plants in saline and alkaline areas of land in Northwest China. However, the mechanisms of salt stress tolerance in A. splendens remain unknown. Next-generation sequencing (NGS) technologies can […]
Economic Evaluations of Opioid Use Disorder Interventions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Abstract Background The economic costs associated with opioid misuse are immense. Effective interventions for opioid use disorders are available; however, given the scarce resources faced by substance use treatment providers and payers of all kinds, evidence of effectiveness is not always sufficient to encourage adoption of a given therapy—nor should it be. Economic evaluations can […]
Cancer Drugs Fund 2.0: A Missed Opportunity?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RfVSaN via IFTTT
Caring touch as a bodily anchor for patients after sustaining a motor vehicle accident with minor or no physical injuries – a mixed methods study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Abstract Background Patients who sustain a motor vehicle accident may experience long-term distress, even if they are uninjured or only slightly injured. There is a risk of neglecting patients with minor or no physical injuries, which might impact future health problems. The aim of this study was to explore patients’ subjective experiences and perspectives on […]
Understanding Outliers and Defining Value in Neonatal Healthcare
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 22 March 2016 Source:The Journal of Pediatrics Author(s): Reese H. Clark, Alan R. Spitzer from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o64UeF via IFTTT
Chilaiditi Syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 22 March 2016 Source:The Journal of Pediatrics Author(s): Havva Evrengül, Selçuk Yüksel, Seda Orpak, Bayram Özhan, Kadir Ağladıoğlu from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ukb0qf via IFTTT
Mismatch Amplification Mutation Assay Real-Time PCR Analysis of the Leptin Gene G2548A and A19G Polymorphisms and Serum Leptin in Infancy: A Preliminary Investigation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Leptin is a hormone that regulates food intake and energy metabolism. Its coding gene (LEP) is one of the most promising candidates for obesity. Although some studies have detected associations of different single nucleotide polymorphisms (SNPs) in the LEP gene with serum leptin levels and obesity-related traits, the results are still conflicting. We investigated two […]
Mismatch Amplification Mutation Assay Real-Time PCR Analysis of the Leptin Gene G2548A and A19G Polymorphisms and Serum Leptin in Infancy: A Preliminary Investigation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Leptin is a hormone that regulates food intake and energy metabolism. Its coding gene (LEP) is one of the most promising candidates for obesity. Although some studies have detected associations of different single nucleotide polymorphisms (SNPs) in the LEP gene with serum leptin levels and obesity-related traits, the results are still conflicting. We investigated two […]
Researchers find a new genetic target for most common lung cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research in Manchester has identified mutations in lung cancer that are key to tumour growth, offering a new way to differentiate and treat some patients with the disease. Non-small cell lung cancer (NSCLC) makes up around 8 in 10 cases of lung cancer… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UFh2RV via IFTTT Medicine by Alexandros […]
La donazione degli organi, una serata informativa – Alto Adige
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
La donazione degli organi, una serata informativa Alto Adige … sono state quindi illustrati alla popolazione locale i più recenti progressi della chirurgia nel campo dei trapianti grazie alla presenza di esperti internazionali come Johann Pratschke, direttore del reparto trapianti dell’ospedale Charitè di … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RjJqW3 via IFTTT Medicine by […]
Epidemiologic evidence of slow growing, non-progressive or regressive breast cancer: a systematic review
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The general aim of this systematic review is to mitigate breast cancer (BC) overdiagnosis and overtreatment. The specific aim is to summarize available data on the occurrence and features of indolent invasive or in situ (DCIS) BC, and precisely survival of untreated cases, prevalence of occult cancers found in autopsies, frequency of regressive BC. […]
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract In this prospective cohort study, we compared the performance of human papillomavirus (HPV) mRNA and DNA testing of women with atypical squamous cells of undetermined significance (ASC-US) during cervical cancer screening. Using a nationwide Danish pathology register, we identified women aged 30–65 years with ASC-US during 2005–2011 who were tested for HPV16/18/31/33/45 mRNA using […]
Use of thermo-coagulation as an alternative treatment modality in a ‘screen and treat’ programme of cervical screening in rural Malawi
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The incidence of cervical cancer in Malawi is the highest in the world and projected to increase in the absence of interventions. Although Government policy supports screening using visual inspection with acetic acid (VIA), screening provision is limited due to lack of infrastructure, trained personnel, cost and availability of gas for cryotherapy. Recently, thermo-coagulation […]
Preferential Tumor Cellular Uptake and Retention of Indocyanine Green for In Vivo Tumor Imaging
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Indocyanine green (ICG) is a fluorescent agent approved for clinical applications by the Food and Drug Administration and European Medicines Agency. This study examined the mechanism of tumor imaging using intravenously administered ICG. The in vivo kinetics of intravenously administered ICG were determined in tumor xenografts using microscopic approaches that enabled both spatio-temporal and […]
Prognostic factors and disease-specific survival among immigrants diagnosed with cutaneous malignant melanoma in Sweden
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Little is known about cutaneous malignant melanoma (CMM) among immigrants in Europe. We aimed to investigate clinical characteristics and disease-specific survival among first- and second-generation immigrants in Sweden This nationwide population-based study included 27,235 patients from the Swedish Melanoma Register diagnosed with primary invasive CMM 1990-2007. Data were linked to nationwide, population-based registers followed […]
Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Acute myelogenous leukemia (AML) has an overall poor survival rate and shows considerable molecular heterogeneity in its etiology. In the WHO classification there are >50 cytogenetic subgroups of AML, many showing highly specific chromosome translocations that lead to constitutive activation of individual kinases. In a rare stem cell leukemia/lymphoma syndrome, translocations involving 8p11 lead […]
Hva er likheten mellom et oblat og en tablett?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Oppsiktsvekkende nok kan man sammenligne oblaten man får utdelt under nattverden med legemiddelbruk. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RjDQDj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
pH-Sensing Hydrogel Fibers: Flexible pH-Sensing Hydrogel Fibers for Epidermal Applications (Adv. Healthcare Mater. 6/2016)
[image: Thumbnail image of graphical abstract] On page 711 S. Sonkusale, A. Khademhosseini, and co-workers present pH-responsive hydrogel fibers that can be used for long-term monitoring of epidermal wound conditions. pH-responsive dyes are loaded into mesoporous microparticles, which are then embedded into hydrogel fibers developed through microfluidic spinning. The fabricated pH-responsive microfibers are flexible and can create conformal contact with skin. Images of the pH-sensing fibers during real-time pH measurement can be captured with a smart phone camera for convenient rea...περισσότερα »
Masthead: (Adv. Healthcare Mater. 6/2016)
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Contents: (Adv. Healthcare Mater. 6/2016)
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Graphene Quantum Dots: Effects of Graphene Quantum Dots on the Self-Renewal and Differentiation of Mesenchymal Stem Cells (Adv. Healthcare Mater. 6/2016)
[image: Thumbnail image of graphical abstract] Fluorescent graphene quantum dots (GQDs) with good biocompatibility have great potential applications in biomedical areas. P. R. Gil, H. Liu, and co-workers' investigation of the interactions between GQDs and mesenchymal stem cells (MSCs) is presented on page 702. When exposed to MSCs, GQDs can be ingested by MSCs and within a certain concentration range GQDs have no significant influence on self-renewal potential of MSCs, but even promote and enhance their osteogenic and adipogenic differentiation at the level of mRNA and protein expr...περισσότερα »
Cancer Imaging: pH-Activatable MnO-Based Fluorescence and Magnetic Resonance Bimodal Nanoprobe for Cancer Imaging (Adv. Healthcare Mater. 6/2016)
[image: Thumbnail image of graphical abstract] On page 721, X. Li, J. Wang, and co-workers report on a MnO-based fluorescence/MRI dual-modality nanoprobe for cancer imaging. While the encapsulated MnO nanoparticles can quench the fluorophores effectively prior to cellular uptake, fluorescence activation is triggered upon dissolution of the MnO nanoparticles to release Mn2+ ions in the acidic lysosomal compartment of the cancer cells. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1o5LRkL via IFTTT
3D evaluation of mandibular skeletal changes in juvenile arthritis patients treated with a distraction splint: A retrospective follow-up
The Angle Orthodontist, Ahead of Print. from #Dental via xlomafota13 on Inoreader http://ift.tt/1S5qbgL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Speciated High-Density Lipoprotein Biogenesis and Functionality
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Plasma high-density lipoprotein cholesterol (HDL-C) concentration is a negative risk factor for atherosclerotic cardiovascular disease (CVD). Despite this, most attempts to raise plasma HDL-C concentrations in a cardioprotective way have failed. Recently, hypotheses about the atheroprotective effects of HDL have shifted away from quantity to quality, mostly HDL function in reverse cholesterol transport. Plasma […]
Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Historically, the relationship between exercise and the cardiovascular system was viewed as unidirectional, with a disease resulting in exercise limitation and hazard. This article reviews and explores the bidirectional nature, delineating the effects, generally positive, on the cardiovascular system and atherosclerosis. Exercise augments eNOS, affects redox potential, and favorably affects mediators of atherosclerosis including […]
Unravelling the relationship between macroautophagy and mitochondrial ROS in cancer therapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Macroautophagy (Autophagy), an evolutionarily conserved cellular self-digesting process implicated in various physiological and pathological processes, is activated by different stimuli including oxidative stress. Reactive oxygen species (ROS) are involved in autophagy modulation through multiple signaling pathways and transcription regulators. Accumulating data support both a positive and negative role of ROS-modulated autophagy in cancer. As […]
Genes, Vol. 7, Pages 12: De Novo Transcriptome Sequencing of Desert Herbaceous Achnatherum splendens (Achnatherum) Seedlings and Identification of Salt Tolerance Genes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Achnatherum splendens is an important forage herb in Northwestern China. It has a high tolerance to salinity and is, thus, considered one of the most important constructive plants in saline and alkaline areas of land in Northwest China. However, the mechanisms of salt stress tolerance in A. splendens remain unknown. Next-generation sequencing (NGS) technologies can […]
Tumore al cavo orale: screening gratuiti il 1° aprile per cercare di prevenirlo – Verona Sera
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Verona Sera Tumore al cavo orale: screening gratuiti il 1° aprile per cercare di prevenirlo Verona Sera … in occasione della “2a giornata di Screening del tumore del cavo orale e testa–collo”, la professionalità del prof. Daniele Marchioni (direttore dell’U.O.C. di Otorinolaringoiatria di Borgo Trento) e del prof. Pier Francesco Nocini (Direttore di … and […]
Effect of Wood Fillers on the Viscoelastic and Thermophysical Properties of HDPE-Wood Composite
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Wood polymer composites (WPC) have well proven their applicability in several fields of the plasturgy sector, due to their aesthetics and low maintenance costs. However, for plasturgy applications, the characterization of viscoelastic behavior and thermomechanical and thermophysical properties of WPC with the temperature and wood filler contents is essential. Therefore, the processability of polymer composites […]
Damage Detection of Structures for Ambient Loading Based on Cross Correlation Function Amplitude and SVM
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
An effective method for the damage detection of skeletal structures which combines the cross correlation function amplitude (CCFA) with the support vector machine (SVM) is presented in this paper. The proposed method consists of two stages. Firstly, the data features are extracted from the CCFA, which, calculated from dynamic responses and as a representation of […]
Road-Aware Routing Strategies for Vehicular Ad Hoc Networks: Characteristics and Comparisons
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The tremendous advancement in new wireless technologies has led to a renewed interest in vehicular ad hoc networks. However, due to the high mobility and dynamic nature of vehicular networks, great challenges exist for data delivery. In order to design efficient and smart routing strategies for stable communication, several different types of routing protocols have […]
Safety Verification of Interconnected Hybrid Systems Using Barrier Certificates
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Safety verification determines whether any trajectory starting from admissible initial states would intersect with a set of unsafe states. In this paper, we propose a numerical method for verifying safety of a network of interconnected hybrid dynamical systems with a state constraint based on bilinear sum-of-squares programming. The safety verification is conducted by the construction […]
Mismatch Amplification Mutation Assay Real-Time PCR Analysis of the Leptin Gene G2548A and A19G Polymorphisms and Serum Leptin in Infancy: A Preliminary Investigation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Leptin is a hormone that regulates food intake and energy metabolism. Its coding gene (LEP) is one of the most promising candidates for obesity. Although some studies have detected associations of different single nucleotide polymorphisms (SNPs) in the LEP gene with serum leptin levels and obesity-related traits, the results are still conflicting. We investigated two […]
Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group
Abstract Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sl... περισσότερα »
Results of Spinal Fusion After Spinal Nerve Sheath Tumor Resection
[image: S18788750.gif] Publication date: June 2016 *Source:*World Neurosurgery, Volume 90 Author(s): Michael Safaee, Taemin Oh, Nicholas M. Barbaro, Dean Chou, Praveen V. Mummaneni, Philip R. Weinstein, Tarik Tihan, Christopher P. Ames IntroductionIntradural extramedullary spine tumors, approximately one-half of which are peripheral nerve sheath tumors (PNSTs), comprise two-thirds of primary spinal neoplasms. Given the rarity of PNSTs and the restricted indications for adding fusion to laminectomy for tumor resection, analyses of spinal fusion outcomes are limited.MethodsDemographics... περισσότερα »
Radiologic Surveillance of Untreated Unruptured Intracranial Aneurysms: A Single Surgeon's Experience
[image: alertIcon.gif] Publication date: June 2016 *Source:*World Neurosurgery, Volume 90 Author(s): Mario Teo, Edward J. St George BackgroundThe management of untreated unruptured intracranial aneurysms remains controversial. The natural history is still not well understood and many patients are not routinely followed up. We present a single surgeon's data on radiologic surveillance of these lesions.MethodsA total of 94 patients with 152 unruptured intracranial aneurysms, with a mean follow-up time of 3.4 years from the time of diagnosis, underwent surveillance using computer tomog... περισσότερα »
Identification of novel inhibitors of the steroid sulfate carrier ‘sodium-dependent organic anion transporter’ SOAT (SLC10A6) by pharmacophore modelling
Publication date: Available online 23 March 2016 Source:Molecular and Cellular Endocrinology Author(s): Gary Grosser, Karl-Heinz Baringhaus, Barbara Döring, Werner Kramer, Ernst Petzinger, Joachim Geyer The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. The present study aimed to identify… Continue reading Identification of novel inhibitors of the steroid sulfate carrier ‘sodium-dependent organic anion transporter’ SOAT (SLC10A6) by pharmacophore mod... περισσότερα »
‘Silencer molecules’ switch off cancer’s ability to spread around body https://t.co/ SeGbuV1e4S https://t.co/PWQwNLDlPB
‘Silencer molecules’ switch off cancer’s ability to spread around body https://t.co/SeGbuV1e4S https://t.co/PWQwNLDlPB from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/712580283422343169 via IFTTT
Guideline Authors’ Response to Dr. Saper’s iNPH Commentary
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1U7LjZA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RyS3iK via IFTTT
RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy
Abstract Studies have demonstrated a relationship between clinical outcomes after curative resection for colorectal cancer (CRC) and gene mutations of the EGFR pathway, however no studies have examined metastatic CRC (mCRC) patients with metastasectomy. The aim of this study was to evaluate the relationship between gene mutations of EGFR pathway and clinical outcomes after metastasectomy… Continue reading RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy
Epidemiologic evidence of slow growing, non-progressive or regressive breast cancer: a systematic review
Abstract The general aim of this systematic review is to mitigate breast cancer (BC) overdiagnosis and overtreatment. The specific aim is to summarize available data on the occurrence and features of indolent invasive or in situ (DCIS) BC, and precisely survival of untreated cases, prevalence of occult cancers found in autopsies, frequency of regressive BC.… Continue reading Epidemiologic evidence of slow growing, non-progressive or regressive breast cancer: a systematic review
The Circumferential Resection Margins status: a comparison of Robotic, laparoscopic and open Total Mesorectal Excision for Mid and Low Rectal Cancer
Publication date: Available online 23 March 2016 Source:European Journal of Surgical Oncology (EJSO) Author(s): José Paulo de Jesus, Marcus Valadão, Rodrigo Otavio de Castro Araujo, Daniel Cesar, Eduardo Linhares, Antonio Carlos Iglesias IntroductionMinimally invasive surgery for rectal cancer (RC) is now widely performed via the laparoscopic approach, but Robotic-assisted surgery may overcome some limitations of… Continue reading The Circumferential Resection Margins status: a comparison of Robotic, laparoscopic and open Total Mesorectal Excision for Mid and Low Rectal Cancer
Angiopoietin-1 attenuates angiotensin II-induced ER stress in glomerular endothelial cells via a Tie2 receptor/ERK1/2-p38 MAPK-dependent mechanism
Publication date: Available online 23 March 2016 Source:Molecular and Cellular Endocrinology Author(s): Xiao Bi, Jianying Niu, Wei Ding, Minmin Zhang, Min Yang, Yong Gu Research has indicated that endoplasmic reticulum (ER) stress in endothelial cells affects vascular pathologies and induces cellular dysfunction and apoptosis. Angiopoietin1 (Angpt1) has been shown to have therapeutic potential in some… Continue reading Angiopoietin-1 attenuates angiotensin II-induced ER stress in glomerular endothelial cells via a Tie2 receptor/ERK1/2-p38 MAPK-dependent mechanism
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study
Abstract In this prospective cohort study, we compared the performance of human papillomavirus (HPV) mRNA and DNA testing of women with atypical squamous cells of undetermined significance (ASC-US) during cervical cancer screening. Using a nationwide Danish pathology register, we identified women aged 30–65 years with ASC-US during 2005–2011 who were tested for HPV16/18/31/33/45 mRNA using… Continue reading Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study
Novel TNF-related Apoptotic-inducing Ligand-based Immunotoxin for Therapeutic Targeting of CD25 Positive Leukemia
Abstract Background Human TNF-related apoptotic-inducing ligand (TRAIL) has been used successfully for targeted therapy of almost all cancers. Leukemia is the most common type of cancer in children, and despite the advances in therapeutic strategies, the survival rate in leukemia cases is very low. Overexpression of interleukin 2 receptor (IL2R) in hematological malignancies has been… Continue reading Novel TNF-related Apoptotic-inducing Ligand-based Immunotoxin for Therapeutic Targeting of CD25 Positive Leukemia
Use of thermo-coagulation as an alternative treatment modality in a ‘screen and treat’ programme of cervical screening in rural Malawi
Abstract The incidence of cervical cancer in Malawi is the highest in the world and projected to increase in the absence of interventions. Although Government policy supports screening using visual inspection with acetic acid (VIA), screening provision is limited due to lack of infrastructure, trained personnel, cost and availability of gas for cryotherapy. Recently, thermo-coagulation… Continue reading Use of thermo-coagulation as an alternative treatment modality in a ‘screen and treat’ programme of cervical screening in rural Malawi
Read 2015's Most Influential Articles from Genome Biology
[image: BioMed eEntral] *Genome Biology* Dear Colleague, We would like to share with you our most influential articles of 2015, according to Altmetric.com. *Influential Articles of 2015* [image: -] The Kardashian index: a measure of discrepant social media profile for scientists [image: -] When will ‘open science’ become simply ‘science’? [image: -] Decoding the massive genome of loblolly pine using haploid DNA and novel assembly strategies [image: -] Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes [image: -] Errors... περισσότερα »
TDG shows antitumor activity by β-GBP and Treg inhibition in oral squamous cell carcinoma
Abstract Objective Thiodigalactoside (TDG), a synthetic inhibitor of *β*-GBP that suppresses tumour growth by inhibiting multiple cancer enhancing activities of *β*-GBP. Hence, we attempted to understand if disruption of *β*-GBP functions and indirect inhibition of Treg cells by TDG affect the growth and establishment of oral cancer cells. Method The growth, morphology, cell cycle regulation, apoptosis induction and angiogenesis of oral cancer cell lines (SCC-4, SCC-9, SCC-25) via MACS purified Treg cells was performed by MTT, propidium iodide (PI) staining, annexin V-binding as... περισσότερα »
Factors Predicting Poor Outcome in a Surgically Managed Series of Multiple Intracranial Aneurysms
Publication date: June 2016 *Source:*World Neurosurgery, Volume 90 Author(s): Pradeep Sharma, Anant Mehrotra, Kuntal Kanti Das, Kamlesh Singh Bhaisora, Jayesh Sardhara, Chaitanya Achyut Godbole, Satyadeo Pandey, Arun Kumar Srivastava, Rabi Narayan Sahu, Awadhesh Kumar Jaiswal, Sanjay Behari ObjectiveMultiple factors are known to influence outcomes in single-aneurysm subarachnoid hemorrhage, such as Hunt and Hess (H&H) grade, hypertension, etc. We sought to assess the influence of individual risk factors on outcome in surgically managed patients with multiple intracranial aneurysm.Me... περισσότερα »
Rectal Manometric Findings and Associated Clinical Changes in Myelopathy from Extradural Spine Pathology
[image: S18788750.gif] Publication date: June 2016 *Source:*World Neurosurgery, Volume 90 Author(s): Anant Mehrotra, Janmejay Jamdar, Abhai Verma, Kuntal Kanti Das, Kamlesh Singh Bhaisora, Jayesh Chunnilal Sardhara, Jaskaran Singh Gosal, Awadhesh Kumar Jaiswal, Rabi Narayan Sahu, Arun Kumar Srivastava, Sanjay Behari ObjectiveStudies of rectal manometric findings in patients with extradural spine diseases are lacking. The objective of this study was to determine the changes in anorectal physiology caused by myelopathy from extradural spine diseases and to correlate these with other c...περισσότερα »
Helmet Use and Head Injury in Homer's Iliad
[image: S18788750.gif] Publication date: June 2016 *Source:*World Neurosurgery, Volume 90 Author(s): Christian Swinney BackgroundHomer's detailed descriptions of head injuries inflicted during the Trojan War are of particular interest to individuals in the medical community. Although studies have examined the prevalence of such injuries, none have examined the preventive measures taken to avoid them. An in-depth review of helmet use in Homer's Iliad was conducted to address this previously unexplored facet of the epic.MethodsAn English translation of Homer's text was reviewed for al...περισσότερα »
Idiopathic Cervical Hematomyelia in an Infant: Spinal Cord Injury without Radiographic Abnormality Caused by a Trivial Trauma? Case Report and Review of the Literature
[image: alertIcon.gif] Publication date: June 2016 *Source:*World Neurosurgery, Volume 90 Author(s): Pietro Fiaschi, Mariasavina Severino, Giuseppe Marcello Ravegnani, Gianluca Piatelli, Alessandro Consales, Andrea Accogli, Valeria Capra, Armando Cama, Marco Pavanello BackgroundSpontaneous or idiopathic intramedullary bleeding is a very rare event in pediatric patients. This diagnosis requires an extended clinical, laboratory, and radiologic work-up to rule out all potential causes of hematomyelia. However, children may present with hematomyelia or spinal cord injury without radiogr...περισσότερα »
Zika Virus Disease: A CDC Update for Pediatric Health Care Providers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Zika virus is a mosquito-borne flavivirus discovered in Africa in 1947. Most persons with Zika virus infection are asymptomatic; symptoms when present are generally mild and include fever, maculopapular rash, arthralgia, and conjunctivitis. Since early 2015, Zika virus has spread rapidly through the Americas, with local transmission identified in 31 countries and territories as of […]
Clinical Practice Guidelines From the Cystic Fibrosis Foundation for Preschoolers With Cystic Fibrosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cystic fibrosis (CF) clinical care guidelines exist for the care of infants up to age 2 years and for individuals ≥6 years of age. An important gap exists for preschool children between the ages of 2 and 5 years. This period marks a time of growth and development that is critical to achieve optimal nutritional […]
Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND AND OBJECTIVE: Knowledge regarding lung function after moderately preterm birth is limited. We therefore investigated lung function at early school age and adolescence among children born moderately preterm. METHODS: Data were used from the Swedish prospective birth cohort BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology study; N = 4089), with a 4.8% […]
Atmosphere, Vol. 7, Pages 49: Seasonal Variations and Correlation Analysis of Water-Soluble Inorganic Ions in PM2.5 in Wuhan, 2013
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Daily PM2.5 and water-soluble inorganic ions (NH4+, SO42−, NO3−, Cl−, Ca2+, Na+, K+, Mg2+) were collected at the Hongshan Air Monitoring Station at the China University of Geosciences (Wuhan) (30°31′N, 114°23′E), Wuhan, from 1 January to 30 December 2013. A total of 52 effective PM2.5 samples were collected using medium flow membrane filter samplers, and […]
Reply to Drs. Halperin, Gronseth, and Gloss
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Guideline Authors’ Response to Dr. Saper’s iNPH Commentary
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1U7LjZA via IFTTT
The Circumferential Resection Margins status: a comparison of Robotic, laparoscopic and open Total Mesorectal Excision for Mid and Low Rectal Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 23 March 2016 Source:European Journal of Surgical Oncology (EJSO) Author(s): José Paulo de Jesus, Marcus Valadão, Rodrigo Otavio de Castro Araujo, Daniel Cesar, Eduardo Linhares, Antonio Carlos Iglesias IntroductionMinimally invasive surgery for rectal cancer (RC) is now widely performed via the laparoscopic approach, but Robotic-assisted surgery may overcome some limitations of […]
Identification of novel inhibitors of the steroid sulfate carrier ‘sodium-dependent organic anion transporter’ SOAT (SLC10A6) by pharmacophore modelling
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 23 March 2016 Source:Molecular and Cellular Endocrinology Author(s): Gary Grosser, Karl-Heinz Baringhaus, Barbara Döring, Werner Kramer, Ernst Petzinger, Joachim Geyer The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. The present study aimed to identify […]
Angiopoietin-1 attenuates angiotensin II-induced ER stress in glomerular endothelial cells via a Tie2 receptor/ERK1/2-p38 MAPK-dependent mechanism
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 23 March 2016 Source:Molecular and Cellular Endocrinology Author(s): Xiao Bi, Jianying Niu, Wei Ding, Minmin Zhang, Min Yang, Yong Gu Research has indicated that endoplasmic reticulum (ER) stress in endothelial cells affects vascular pathologies and induces cellular dysfunction and apoptosis. Angiopoietin1 (Angpt1) has been shown to have therapeutic potential in some […]
Novel TNF-related Apoptotic-inducing Ligand-based Immunotoxin for Therapeutic Targeting of CD25 Positive Leukemia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Human TNF-related apoptotic-inducing ligand (TRAIL) has been used successfully for targeted therapy of almost all cancers. Leukemia is the most common type of cancer in children, and despite the advances in therapeutic strategies, the survival rate in leukemia cases is very low. Overexpression of interleukin 2 receptor (IL2R) in hematological malignancies has been […]
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