An Exploration of Methods for Rating Children's Productions of Sibilant Fricatives.
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 4 δευτερόλεπτα
Related Articles *An Exploration of Methods for Rating Children's Productions of Sibilant Fricatives.* Speech Lang Hear. 2016;19(1):36-45 Authors: Munson B, Carlson KU Abstract This paper examines three methods for providing ratings of within-category detail in children's productions of /s/ and /ʃ/. A group of listeners (n=61) participated in a rating task in which a forced-choice phoneme identification task was followed by one of three measures of phoneme goodness: visual analog scaling, direct magnitude estimation, or a Likert scale judgment. All three types of ratings were si... περισσότερα »
An Exploration of Methods for Rating Children's Productions of Sibilant Fricatives.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
Related Articles *An Exploration of Methods for Rating Children's Productions of Sibilant Fricatives.* Speech Lang Hear. 2016;19(1):36-45 Authors: Munson B, Carlson KU Abstract This paper examines three methods for providing ratings of within-category detail in children's productions of /s/ and /ʃ/. A group of listeners (n=61) participated in a rating task in which a forced-choice phoneme identification task was followed by one of three measures of phoneme goodness: visual analog scaling, direct magnitude estimation, or a Likert scale judgment. All three types of ratings were si... περισσότερα »
Early Electroencephalographic Findings Correlate With Neurologic Outcome in Children Following Cardiac Arrest.
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Objectives: To determine the clinical and electroencephalographic findings associated with prognosis in nonneonate children following cardiac arrest. Design: Retrospective observational study. Setting: PICU and cardiac ICU. Patients: Nonneonate children with a history of cardiac arrest more than 2 minutes. Interventions: Electroencephalographic monitoring within 72 hours of return of spontaneous circulation. Measurements and Main Results: Clinical and features, neurophysiologic data, and Pediatric Cerebral Performance Category scores were collected. Electroencephalographic traces we... περισσότερα »
Introducing Academic Emergency Medicine Education and Training
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
We are excited to announce the birth of a new journal dedicated to emergency medicine educational scholarship. The new journal will be called *Academic Emergency Medicine Education and Training (AEM A&T)*. As of June 16 2016, *Academic Emergency Medicine* will no longer review or accept manuscripts that center on education or training of emergency care providers. Instead, we will offer the manuscript's authors a choice of either having the paper reviewed for possible publication in the new journal, *Academic Emergency Medicine Education and Training* or the option of withdrawing th... περισσότερα »
Vestibular evoked myogenic potentials (VEMPs): Tailoring methodology to specific conditions
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
[image: alertIcon.gif] Publication date: June 2016 *Source:*Clinical Neurophysiology, Volume 127, Issue 6 Author(s): Eleftherios S. Papathanasiou from Physiology via xlomafota13 on Inoreader http://ift.tt/24MMkfw
Towards the application of HD-EMG decomposition in clinical practice
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
[image: alertIcon.gif] Publication date: June 2016 *Source:*Clinical Neurophysiology, Volume 127, Issue 6 Author(s): Miguel A. Mañanas, Mónica Rojas-Martínez, Joan F. Alonso from Physiology via xlomafota13 on Inoreader http://ift.tt/1TE7nFM
The Origin of the Abnormal Muscle Response Seen in Hemifacial Spasm Remains Controversial
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 10 May 2016 *Source:*Clinical Neurophysiology Author(s): Anthony M. Kaufmann, Marshall Wilkinson from Physiology via xlomafota13 on Inoreader http://ift.tt/1TE7p0a
Properties of 500Hz air- and bone-conducted vestibular evoked myogenic potentials (VEMPs) in superior canal dehiscence
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
[image: alertIcon.gif] Publication date: June 2016 *Source:*Clinical Neurophysiology, Volume 127, Issue 6 Author(s): Sendhil Govender, Tavish Fernando, Danielle L. Dennis, Miriam S. Welgampola, James G. Colebatch ObjectivesTo compare threshold and amplitude properties for air- (AC) and mastoid bone-conducted (BC) cervical (cVEMP) and ocular (oVEMP) vestibular evoked myogenic potentials in superior canal dehiscence (SCD).MethodsThirteen patients (53±14yrs) clinically diagnosed with SCD were tested using AC 500Hz sound and BC 500Hz transmastoid vibration. Baseline intensities of 135dB... περισσότερα »
Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
Sequential patterns of prefrontal activity are believed to mediate important behaviors, e.g., working memory, but it remains unclear exactly how they are generated. In accordance with previous studies of cortical circuits, we found that prefrontal microcircuits in young adult mice spontaneously generate many more stereotyped sequences of activity than expected by chance. However, the key question of whether these sequences depend on a specific functional organization within the cortical microcircuit, or emerge simply as a by-product of random interactions between neurons, remains ... περισσότερα »
Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
Ca2+-activated potassium currents [*I*K(Ca)] are an important link between the intracellular signaling system and the membrane potential, which shapes intrinsic electrophysiological properties. To better understand the ionic mechanisms that mediate intrinsic firing properties of olfactory uniglomerular projection neurons (uPNs), we used whole cell patch-clamp recordings in an intact adult brain preparation of the male cockroach *Periplaneta americana* to analyze *I*K(Ca). In the insect brain, uPNs form the principal pathway from the antennal lobe to the protocerebrum, where center... περισσότερα »
Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
The action potential (AP) is a fundamental feature of excitable cells that serves as the basis for long-distance signaling in the nervous system. There is considerable diversity in the appearance of APs and the underlying repolarization mechanisms in different neuronal types (reviewed in Bean BP. *Nat Rev Neurosci* 8: 451–465, 2007), including among pyramidal cell subtypes. In the present work, we used specific pharmacological blockers to test for contributions of Kv1, Kv2, or Kv4 channels to repolarization of single APs in two genetically defined subpopulations of pyramidal cells ... περισσότερα »
Blocking trial-by-trial error correction does not interfere with motor learning in human walking
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
Movements can be learned implicitly in response to new environmental demands or explicitly through instruction and strategy. The former is often studied in an environment that perturbs movement so that people learn to correct the errors and store a new motor pattern. Here, we demonstrate in human walking that implicit learning of foot placement occurs even when an explicit strategy is used to block changes in foot placement during the learning process. We studied people learning a new walking pattern on a split-belt treadmill with and without an explicit strategy through instructi... περισσότερα »
An asymmetric outer retinal response to drifting sawtooth gratings
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
Electroretinogram (ERG) studies have demonstrated that the retinal response to temporally modulated fast-ON and fast-OFF sawtooth flicker is asymmetric. The response to spatiotemporal sawtooth stimuli has not yet been investigated. Perceptually, such drifting gratings or diamond plaids shaded in a sawtooth pattern appear brighter when movement produces fast-OFF relative to fast-ON luminance profiles. The neural origins of this illusion remain unclear (although a retinal basis has been suggested). Thus we presented toad eyecups with sequential epochs of sawtooth, sine-wave, and squ...περισσότερα »
Classification of odorants across layers in locust olfactory pathway
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
Olfactory processing takes place across multiple layers of neurons from the transduction of odorants in the periphery, to odor quality processing, learning, and decision making in higher olfactory structures. In insects, projection neurons (PNs) in the antennal lobe send odor information to the Kenyon cells (KCs) of the mushroom bodies and lateral horn neurons (LHNs). To examine the odor information content in different structures of the insect brain, antennal lobe, mushroom bodies and lateral horn, we designed a model of the olfactory network based on electrophysiological recordin... περισσότερα »
Sonographic Features of Thyroidal Fatty Lesions in the Thyroid Gland: A Preliminary Study
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
American Journal of Roentgenology, Ahead of Print. from thyroid via a.lsfakia on Inoreader http://ift.tt/1OgNlF4 via IFTTT
Uterine morphology during diapause and early pregnancy in the tammar wallaby (Macropus eugenii)
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Abstract In mammals, embryonic diapause, or suspension of embryonic development, occurs when embryos at the blastocyst stage are arrested in growth and metabolism. In the tammar wallaby (Macropus eugenii), there are two separate uteri, only one of which becomes gravid with the single conceptus at a post-partum oestrus, so changes during pregnancy can be compared […]
Switch Flap for Upper Eyelid Reconstruction—How Soon Should the Flap Be Divided?
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
[image: image]Background: The results of a cohort of patients treated at one institution for upper eyelid reconstruction with the switch flap method after a defect due to excision of malignant tumor were reviewed. Methods: A retrospective data file review of all patients who had undergone total upper eyelid reconstruction with the switch flap method was conducted at the Saga University Hospital between April 2000 and October 2014. The follow-up lasted for varying periods during which the preoperative and postoperative photographs were compared as well. Results: A total of 10 patient... περισσότερα »
Use of novel psychoactive substances by inpatients on general adult psychiatric wards
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Objectives Non-illicit alternatives to controlled drugs, known as novel psychoactive substances (NPS), have recently risen to prominence. They are readily available, with uncertain pharmacology and no widely available assay. Given that psychiatric patients are at risk of comorbid substance abuse, we hypothesised that NPS use would be present in the psychiatric population, and sought to determine its prevalence and investigate the characteristics of those who use these drugs with a retrospective review of discharge letters. Setting General adult inpatient wards of a psychiatric ... περισσότερα »
Irie Classroom Toolbox: a study protocol for a cluster-randomised trial of a universal violence prevention programme in Jamaican preschools
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Introduction We aim to determine the effectiveness of a school-based violence prevention programme implemented in Jamaican preschools, on reducing the levels of aggression among children at school, and violence against children by teachers. Methods and analysis This is a 2-arm, single-blind, cluster-randomised controlled trial with parallel assignment. Clusters are 76 preschools in Kingston, and all teachers and classrooms in the selected schools are included in the study. In addition, a random sample of up to 12 children in the 4-year-old classes have been selected for evaluat... περισσότερα »
Health coaching and pedometers to enhance physical activity and prevent falls in community-dwelling people aged 60 years and over: study protocol for the Coaching for Healthy AGEing (CHAnGE) cluster randomised controlled trial
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Introduction Prevention of falls and promotion of physical activity are essential for maximising well-being in older age. However, there is evidence that promoting physical activity among older people without providing fall prevention advice may increase fall rates. This trial aims to establish the impact of a physical activity and fall prevention programme compared with a healthy eating programme on physical activity and falls among people aged 60+ years. Methods and analysis This cluster randomised controlled trial will involve 60 groups of community-dwelling people aged 60+ ... περισσότερα »
Marine Drugs, Vol. 14, Pages 91: Effect of Chitosan Properties on Immunoreactivity
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
[image: ag] Chitosan is a widely investigated biopolymer in drug and gene delivery, tissue engineering and vaccine development. However, the immune response to chitosan is not clearly understood due to contradicting results in literature regarding its immunoreactivity. Thus, in this study, we analyzed effects of various biochemical properties, namely degree of deacetylation (DDA), viscosity/polymer length and endotoxin levels, on immune responses by antigen presenting cells (APCs). Chitosan solutions from various sources were treated with mouse and human APCs (macrophages and/or de...περισσότερα »
Sustainability, Vol. 8, Pages 463: System Merits or Failures? Policies for Transition to Sustainable P and N Systems in The Netherlands and Finland
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Nitrogen (N) and phosphorus (P) cycles are absolutely vital in maintaining sustainable food systems. Human activities disturb the natural balance of these cycles by creating enormous additional nutrient fluxes, causing eutrophication of waterways and pollution in land systems. To tackle this problem, sustainable nutrient management is required. This paper addresses sustainable nutrient management in two countries: The Netherlands and Finland. We adopt a critical perspective on resource politics, especially towards opportunistic policy strategies for the pollutant management of N a... περισσότερα »
Sensors, Vol. 16, Pages 674: Bootstrapping Security Policies for Wearable Apps Using Attributed Structural Graphs
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
We address the problem of bootstrapping security and privacy policies for newly-deployed apps in wireless body area networks (WBAN) composed of smartphones, sensors and other wearable devices. We introduce a framework to model such a WBAN as an undirected graph whose vertices correspond to devices, apps and app resources, while edges model structural relationships among them. This graph is then augmented with attributes capturing the features of each entity together with user-defined tags. We then adapt available graph-based similarity metrics to find the closest app to a new one ... περισσότερα »
Applied Sciences, Vol. 6, Pages 146: Tests and Analysis of the Compressive Performance of an Integrated Masonry Structure of a Brick-Stem-Insulating Layer
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
This paper proposes, for low buildings, an integrated wall structure of a brick-stem-insulating layer, which plays a major part in both heat preservation and force bearing. The research team has tested the thermal performance of the structure, the results of which are satisfying. To further study the force-bearing performance, the paper carries out compressive tests of specimens of different structural design, with two types of bricks, i.e., clay and recycled concrete bricks; three types of stems, i.e., square-shaped wood, square-shaped steel pipe and circular steel pipe; and one ... περισσότερα »
Nutrients, Vol. 8, Pages 277: A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women—A Randomized Controlled Trial
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Flavonoids and fish oils have anti-inflammatory and immune-modulating influences. The purpose of this study was to determine if a mixed flavonoid-fish oil supplement (Q-Mix; 1000 mg quercetin, 400 mg isoquercetin, 120 mg epigallocatechin (EGCG) from green tea extract, 400 mg n3-PUFAs (omega-3 polyunsaturated fatty acid) (220 mg eicosapentaenoic acid (EPA) and 180 mg docosahexaenoic acid (DHA)) from fish oil, 1000 mg vitamin C, 40 mg niacinamide, and 800 µg folic acid) would reduce complications associated with obesity; that is, reduce inflammatory and oxidative stress markers and ...περισσότερα »
Water, Vol. 8, Pages 196: The Status of Domestic Water Demand: Supply Deficit in the Kathmandu Valley, Nepal
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
United Nations Sustainable Development Goal 6 targets access to water and sanitation for all people in the next 15 years. However, for developing countries such as Nepal, it is more challenging to achieve this goal given its poor infrastructure and high population growth. To assess the water crisis in the most developed and populated area of Nepal, the Kathmandu Valley, we estimated available water resources and domestic water demand in the valley. We estimated a supply deficit of 102 million liters per day (MLD) in 2016, after completion of the first phase of the Melamchi Water S... περισσότερα »
Processes, Vol. 4, Pages 16: Process Intensification via Membrane Reactors, the DEMCAMER Project
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
This paper reports the findings of a FP7 project (DEMCAMER) that developed materials (catalysts and membranes) and new processes for four industrially relevant reaction processes. In this project, active, stable, and selective catalysts were developed for the reaction systems of interest and their production scaled up to kg scale (TRL5 (TRL: Technology Readiness Level)). Simultaneously, new membranes for gas separation were developed; in particular, dense supported thin palladium-based membranes for hydrogen separation from reactive mixtures. These membranes were successfully scale...περισσότερα »
MCA, Vol. 21, Pages 17: Three-Parameter Interval Grey Number Multi-Attribute Decision Making Method Based on Information Entropy
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Aimed at the situation that the plan attribute value is a three-parameter interval grey number and that attribute weight is uncertain, a three-parameter interval grey number multi-attribute decision making method based on information entropy is proposed. In this study, we combine the three-parameter interval grey number decision-making problem with information entropy, build the distance entropy model of the three-parameter interval grey number, and provide a solution to the empowerment problem of the three-parameter interval grey number in grey decision-making problems. On this b...περισσότερα »
Sustainability, Vol. 8, Pages 464: Towards a Model of Sustainable Competitiveness of Health Organizations
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Over the last decades, around the world, the concept of competitiveness was long debated by economists (and others), widely used and even sometimes overused. Although at the theoretical level, a number of determinant factors of health care organizations' competitiveness have been proposed, their diversity and the little empirical data available argues for the need to create and validate a model of competitiveness of health organizations. The purpose of this paper is (considering the theoretical approach) to shape a model of sustainable competitiveness of health organizations. In t... περισσότερα »
Uterine morphology during diapause and early pregnancy in the tammar wallaby (Macropus eugenii)
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 10 δευτερόλεπτα
Abstract In mammals, embryonic diapause, or suspension of embryonic development, occurs when embryos at the blastocyst stage are arrested in growth and metabolism. In the tammar wallaby (*Macropus eugenii*), there are two separate uteri, only one of which becomes gravid with the single conceptus at a post-partum oestrus, so changes during pregnancy can be compared between the gravid and non-gravid uterus within the same individual. Maintenance of the viable blastocyst and inhibition of further conceptus growth during diapause in the tammar is completely dependent on the uterine en... περισσότερα »
Characterization of the myoepithelial cells in the major salivary glands of the fruit bat Artibeus jamaicensis
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 10 δευτερόλεπτα
Abstract Bats constitute one of the most numerous mammalian species. Bats have a wide range of dietary habits and include carnivorous, haematophagous, insectivorous, frugivorous and nectivorous species. The salivary glands of these species have been of particular research interest due to their structural variability among chiropterans with different types of diets. Myoepithelial cells (MECs), which support and facilitate the expulsion of saliva from the secretory portions of salivary glands, are very important for their function; however, this cell type has not been extensively st... περισσότερα »
Use of novel psychoactive substances by inpatients on general adult psychiatric wards
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Objectives Non-illicit alternatives to controlled drugs, known as novel psychoactive substances (NPS), have recently risen to prominence. They are readily available, with uncertain pharmacology and no widely available assay. Given that psychiatric patients are at risk of comorbid substance abuse, we hypothesised that NPS use would be present in the psychiatric population, and sought to determine its prevalence and investigate the characteristics of those who use these drugs with a retrospective review of discharge letters. Setting General adult inpatient wards of a psychiatric ... περισσότερα »
Irie Classroom Toolbox: a study protocol for a cluster-randomised trial of a universal violence prevention programme in Jamaican preschools
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Introduction We aim to determine the effectiveness of a school-based violence prevention programme implemented in Jamaican preschools, on reducing the levels of aggression among children at school, and violence against children by teachers. Methods and analysis This is a 2-arm, single-blind, cluster-randomised controlled trial with parallel assignment. Clusters are 76 preschools in Kingston, and all teachers and classrooms in the selected schools are included in the study. In addition, a random sample of up to 12 children in the 4-year-old classes have been selected for evaluat... περισσότερα »
Health coaching and pedometers to enhance physical activity and prevent falls in community-dwelling people aged 60 years and over: study protocol for the Coaching for Healthy AGEing (CHAnGE) cluster randomised controlled trial
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Introduction Prevention of falls and promotion of physical activity are essential for maximising well-being in older age. However, there is evidence that promoting physical activity among older people without providing fall prevention advice may increase fall rates. This trial aims to establish the impact of a physical activity and fall prevention programme compared with a healthy eating programme on physical activity and falls among people aged 60+ years. Methods and analysis This cluster randomised controlled trial will involve 60 groups of community-dwelling people aged 60+ ... περισσότερα »
Marine Drugs, Vol. 14, Pages 91: Effect of Chitosan Properties on Immunoreactivity
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
[image: ag] Chitosan is a widely investigated biopolymer in drug and gene delivery, tissue engineering and vaccine development. However, the immune response to chitosan is not clearly understood due to contradicting results in literature regarding its immunoreactivity. Thus, in this study, we analyzed effects of various biochemical properties, namely degree of deacetylation (DDA), viscosity/polymer length and endotoxin levels, on immune responses by antigen presenting cells (APCs). Chitosan solutions from various sources were treated with mouse and human APCs (macrophages and/or de...περισσότερα »
Sustainability, Vol. 8, Pages 463: System Merits or Failures? Policies for Transition to Sustainable P and N Systems in The Netherlands and Finland
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Nitrogen (N) and phosphorus (P) cycles are absolutely vital in maintaining sustainable food systems. Human activities disturb the natural balance of these cycles by creating enormous additional nutrient fluxes, causing eutrophication of waterways and pollution in land systems. To tackle this problem, sustainable nutrient management is required. This paper addresses sustainable nutrient management in two countries: The Netherlands and Finland. We adopt a critical perspective on resource politics, especially towards opportunistic policy strategies for the pollutant management of N a... περισσότερα »
Sensors, Vol. 16, Pages 674: Bootstrapping Security Policies for Wearable Apps Using Attributed Structural Graphs
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
We address the problem of bootstrapping security and privacy policies for newly-deployed apps in wireless body area networks (WBAN) composed of smartphones, sensors and other wearable devices. We introduce a framework to model such a WBAN as an undirected graph whose vertices correspond to devices, apps and app resources, while edges model structural relationships among them. This graph is then augmented with attributes capturing the features of each entity together with user-defined tags. We then adapt available graph-based similarity metrics to find the closest app to a new one ... περισσότερα »
Applied Sciences, Vol. 6, Pages 146: Tests and Analysis of the Compressive Performance of an Integrated Masonry Structure of a Brick-Stem-Insulating Layer
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
This paper proposes, for low buildings, an integrated wall structure of a brick-stem-insulating layer, which plays a major part in both heat preservation and force bearing. The research team has tested the thermal performance of the structure, the results of which are satisfying. To further study the force-bearing performance, the paper carries out compressive tests of specimens of different structural design, with two types of bricks, i.e., clay and recycled concrete bricks; three types of stems, i.e., square-shaped wood, square-shaped steel pipe and circular steel pipe; and one ... περισσότερα »
Nutrients, Vol. 8, Pages 277: A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women—A Randomized Controlled Trial
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Flavonoids and fish oils have anti-inflammatory and immune-modulating influences. The purpose of this study was to determine if a mixed flavonoid-fish oil supplement (Q-Mix; 1000 mg quercetin, 400 mg isoquercetin, 120 mg epigallocatechin (EGCG) from green tea extract, 400 mg n3-PUFAs (omega-3 polyunsaturated fatty acid) (220 mg eicosapentaenoic acid (EPA) and 180 mg docosahexaenoic acid (DHA)) from fish oil, 1000 mg vitamin C, 40 mg niacinamide, and 800 µg folic acid) would reduce complications associated with obesity; that is, reduce inflammatory and oxidative stress markers and ...περισσότερα »
Water, Vol. 8, Pages 196: The Status of Domestic Water Demand: Supply Deficit in the Kathmandu Valley, Nepal
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
United Nations Sustainable Development Goal 6 targets access to water and sanitation for all people in the next 15 years. However, for developing countries such as Nepal, it is more challenging to achieve this goal given its poor infrastructure and high population growth. To assess the water crisis in the most developed and populated area of Nepal, the Kathmandu Valley, we estimated available water resources and domestic water demand in the valley. We estimated a supply deficit of 102 million liters per day (MLD) in 2016, after completion of the first phase of the Melamchi Water S... περισσότερα »
Processes, Vol. 4, Pages 16: Process Intensification via Membrane Reactors, the DEMCAMER Project
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
This paper reports the findings of a FP7 project (DEMCAMER) that developed materials (catalysts and membranes) and new processes for four industrially relevant reaction processes. In this project, active, stable, and selective catalysts were developed for the reaction systems of interest and their production scaled up to kg scale (TRL5 (TRL: Technology Readiness Level)). Simultaneously, new membranes for gas separation were developed; in particular, dense supported thin palladium-based membranes for hydrogen separation from reactive mixtures. These membranes were successfully scale...περισσότερα »
Early Electroencephalographic Findings Correlate With Neurologic Outcome in Children Following Cardiac Arrest.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Objectives: To determine the clinical and electroencephalographic findings associated with prognosis in nonneonate children following cardiac arrest. Design: Retrospective observational study. Setting: PICU and cardiac ICU. Patients: Nonneonate children with a history of cardiac arrest more than 2 minutes. Interventions: Electroencephalographic monitoring within 72 hours of return of spontaneous circulation. Measurements and Main Results: Clinical and features, neurophysiologic data, and Pediatric Cerebral Performance Category scores were collected. Electroencephalographic traces we... περισσότερα »
Anti-TNF-alpha Agent Infliximab and Splenectomy Are Protective Against Renal Ischemia-Reperfusion Injury.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Background: Renal ischemia-reperfusion (I/R) injury is associated with delayed graft function and results in poor long-term graft survival. We previously showed that splenectomy (SPLN) protects the kidney from I/R injury and reduces serum TNF-[alpha] levels. Herein, we further investigated the effects of SPLN on inflammatory responses and tissue injury in renal I/R by examining the […]
Tumor Necrosis Factor alpha Blockade to Ameliorate Renal ischemia Reperfusion Injury: Potential Implications for Kidney Transplantation.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
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Targeting JAK/STAT Signaling to Prevent Rejection After Kidney Transplantation: A Reappraisal.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
The profound involvement of cytokines in allograft rejection makes the molecules that control their actions, members of the Jak-Stat pathway, ideal targets for pharmacological intervention. Numerous studies have demonstrated that Jak3 is widely involved in the activation cascade and function of most immune cells. Tofacitinib, an oral Janus kinase inhibitor that targets Jak1/Jak3 dependent Stat […]
High Posttransplant Cancer Incidence in Renal Transplanted Patients With Pretransplant Cancer.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Background: Patients with previous cancer have increasingly been accepted for renal transplantation. Posttransplant cancer risk and survival rates of these patients are unknown. Our objective was to assess the risk of posttransplant cancer in this patient group. Methods: In this retrospective, nested case-control study, we assessed the outcome of all (n = 95) renal transplanted […]
Remodeling of Dendritic Spines in the Avian Vocal Motor Cortex Following Deafening Depends on the Basal Ganglia Circuit
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
Deafening elicits a deterioration of learned vocalization, in both humans and songbirds. In songbirds, learned vocal plasticity has been shown to depend on the basal ganglia-cortical circuit, but the underlying cellular basis remains to be clarified. Using confocal imaging and electron microscopy, we examined the effect of deafening on dendritic spines in avian vocal motor cortex, the robust nucleus of the arcopallium (RA), and investigated the role of the basal ganglia circuit in motor cortex plasticity. We found rapid structural changes to RA dendritic spines in response to hear... περισσότερα »
New Role of ATM in Controlling GABAergic Tone During Development
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
The capacity to guarantee the proper excitatory/inhibitory balance is one of the most critical steps during early development responsible for the correct brain organization, function, and plasticity. GABAergic neurons guide this process leading to the right structural organization, brain circuitry, and neuronal firing. Here, we identified the ataxia telangiectasia mutated (ATM), a serine/threonine protein kinase linked to DNA damage response, as crucial in regulating neurotransmission. We found that reduced levels of ATM in the hippocampal neuronal cultures produce an excitatory/i... περισσότερα »
Transcranial Direct-Current Stimulation Can Enhance Motor Learning in Children
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
This study aims to determine the effects of transcranial direct-current stimulation (tDCS) on motor learning in healthy school-aged children. Safety, tolerability, and translation of effects to untrained tasks were also explored. We recruited 24 right-handed children for a randomized, sham-controlled, double-blinded trial to receive: right primary motor cortex (M1) 1 mA anodal (1A-tDCS), left M1 1 mA cathodal (1C-tDCS), left M1 2 mA cathodal tDCS (2C-tDCS), or sham tDCS over 3 consecutive days of motor task practice. Participants trained their left hand to perform the Purdue Pegbo... περισσότερα »
The Addiction-Related Protein ANKK1 is Differentially Expressed During the Cell Cycle in Neural Precursors
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
*Taq*IA is a polymorphism associated with addictions and dopamine-related traits. It is located in the ankyrin repeat and kinase domain containing 1 gene (*ANKK1*) nearby the gene for the dopamine D2 receptor (D2R). Since ANKK1 function is unknown, *Taq*IA-associated traits have been explained only by differences in D2R. Here we report *ANKK1* studies in mouse and human brain using quantitative real-time PCR, Western blot, immunohistochemistry, and flow cytometry. *ANKK1* mRNA and protein isoforms vary along neurodevelopment in the human and mouse brain. In mouse adult brain ANKK1... περισσότερα »
Look Hear! The Prefrontal Cortex is Stratified by Modality of Sensory Input During Multisensory Cognitive Control
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
Parsing multisensory information from a complex external environment is a fundamental skill for all organisms. However, different organizational schemes currently exist for how multisensory information is processed in human (supramodal; organized by cognitive demands) versus primate (organized by modality/cognitive demands) lateral prefrontal cortex (LPFC). Functional magnetic resonance imaging results from a large cohort of healthy controls (*N* = 64; Experiment 1) revealed a rostral-caudal stratification of LPFC for auditory versus visual attention during an audio-visual Stroop ... περισσότερα »
Modulation of Functional Connectivity in Auditory-Motor Networks in Musicians Compared with Nonmusicians
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
Correlation of spontaneous fluctuations at rest between anatomically distinct brain areas are proposed to reflect the profile of individual a priori cognitive biases, coded as synaptic efficacies in cortical networks. Here, we investigate functional connectivity at rest (rs-FC) in musicians and nonmusicians to test for differences in auditory, motor, and audiomotor connectivity. As expected, musicians had stronger rs-FC between the right auditory cortex (AC) and the right ventral premotor cortex than nonmusicians, and this stronger rs-FC was greater in musicians with more years of... περισσότερα »
Nogo-66 Restricts Synaptic Strengthening via Lingo1 and the ROCK2-Cofilin Pathway to Control Actin Dynamics
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
Nogo-A restricts long-term potentiation (LTP) at the Schaffer collateral–CA1 pathway in the adult hippocampus via 2 extracellular domains: Nogo-A-20 and Nogo-66. Nogo-66 signals via Nogo Receptor 1 (NgR1) to regulate synaptic function. Whether the NgR1 coreceptors Lingo1 and p75 NTR are involved in the signaling in this context is still not known. Moreover, the intracellular cascade mediating the activity of Nogo-66 in restricting LTP is unexplored. We combine electrophysiology and biochemistry in acute hippocampal slices and demonstrate that a loss of function for Lingo1 results i... περισσότερα »
Learned Value Shapes Responses to Objects in Frontal and Ventral Stream Networks in Macaque Monkeys
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 16 δευτερόλεπτα
We have an incomplete picture of how the brain links object representations to reward value, and how this information is stored and later retrieved. The orbitofrontal cortex (OFC), medial frontal cortex (MFC), and ventrolateral prefrontal cortex (VLPFC), together with the amygdala, are thought to play key roles in these processes. There is an apparent discrepancy, however, regarding frontal areas thought to encode value in macaque monkeys versus humans. To address this issue, we used fMRI in macaque monkeys to localize brain areas encoding recently learned image values. Each week,... περισσότερα »
In the face of increasing subspecialisation, how does the specialty ensure that the management of ENT emergencies is timely, appropriate and safe?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Review ArticleIn the face of increasing subspecialisation, how does the specialty ensure that the management of ENT emergencies is timely, appropriate and safe?M J Rouhani University of Cambridge School of Clinical Medicine, UK Abstract Background: The field of ENT surgery is one of the most varied specialties, with numerous subspecialties and continuing divergence. With this evolution there comes, however, a risk that specialists become de-skilled in certain areas. In the case of ENT emergencies, this can be particularly dangerous. Methods: Current guidance from relevant UK professio...περισσότερα »
Pediatric airway management is a low-frequency, high-risk skill that requires ongoing training and practice to maintain proficiency. Providers may consider utilizing an alternative airway, such as the LMA or the King LT-D, when managing the pediatric airway rather than resorting to intubation. For services that utilize surgical airways for pediatric patients, this skill requires a great deal of ongoing training and practice as evidenced by the poor success rate among many emergency providers. The cornerstone of pediatric airway management remains basic airway maneuvers, and providers should only consider moving to advanced procedures if the basic maneuvers are not effective in maintaining adequate ventilation and oxygenation.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Controversies in the paramedic management of the pediatric airway: By Christopher Boyer The most current version of the EMS Educational Standards requires providers of all skill levels to be able to manage the pediatric patient’s airway [1]. The level of management ranges from basic airway adjuncts and ventilation at the EMT level to intubation and needle cricothyrotomy at the paramedic level. Despite these training requirements, EMS practitioners utilize these skills infrequently, resulting in a high-risk, low-frequency skill that providers must remain competent in through contin...περισσότερα »
Pediatric Airway Management : Respiratory arrest is the predominant cause of mortality in critically ill and injured children. Prehospital airway management can be life saving for critically ill or injured children but is a low-frequency, high-risk event fraught with the potential for error. Basic airway maneuvers are the cornerstone of maintenance of oxygenation and ventilation by EMS professionals in the field. Overall, the incorporation of pediatric intubation in prehospital protocols has demonstrated more negative than positive impact. In a landmark study comparing prehospital intubation to BVM only, "no statistically significant difference was seen for either survival to hospital discharge or good neurologic outcomes.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Controversies in the paramedic management of the pediatric airway: By Christopher Boyer The most current version of the EMS Educational Standards requires providers of all skill levels to be able to manage the pediatric patient’s airway [1]. The level of management ranges from basic airway adjuncts and ventilation at the EMT level to intubation and needle cricothyrotomy at the paramedic level. Despite these training requirements, EMS practitioners utilize these skills infrequently, resulting in a high-risk, low-frequency skill that providers must remain competent in through contin...περισσότερα »
Recognition of the need for advanced airway management Proper selection of appropriate sized equipment Appropriate intubation techniques with direct or video laryngoscopy Utilization of an alternative airway device, like an LMA or King, as deemed appropriate Utilization of an appropriate surgical airway technique for situation with a full or partial obstruction proximal to the glottic opening that is preventing intubation or oxygenation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Controversies in the paramedic management of the pediatric airway: By Christopher Boyer The most current version of the EMS Educational Standards requires providers of all skill levels to be able to manage the pediatric patient’s airway [1]. The level of management ranges from basic airway adjuncts and ventilation at the EMT level to intubation and needle cricothyrotomy at the paramedic level. Despite these training requirements, EMS practitioners utilize these skills infrequently, resulting in a high-risk, low-frequency skill that providers must remain competent in through contin...περισσότερα »
The paramedic management of the pediatric airway : Proper positioning of the airway, including padding behind the shoulder blades in infants and young toddlers Monitoring of respiratory status including waveform capnography and pulse-oximetry Managing airway obstruction while remembering the pediatric airway is more susceptible to obstruction by both foreign body aspiration and soft tissue swelling than the adult Administration of supplemental oxygen as needed Effective BVM ventilation at an appropriate rate Utilization of appropriate airway adjuncts including oral and nasal airways
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Controversies in By Christopher Boyer The most current version of the EMS Educational Standards requires providers of all skill levels to be able to manage the pediatric patient’s airway [1]. The level of management ranges from basic airway adjuncts and ventilation at the EMT level to intubation and needle cricothyrotomy at the paramedic level. Despite these training requirements, EMS practitioners utilize these skills infrequently, resulting in a high-risk, low-frequency skill that providers must remain competent in through continuing education [2]. The need for an increase in t... περισσότερα »
Pediatric Asthma : Assessment and management
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Reality Training By Christopher Kroboth Asthma is a condition in which lower airways narrow and swell and produce extra mucus. This can make breathing difficult and trigger coughing, wheezing and shortness of breath [1]. The CDC reports that 8.3 percent of the pediatric population has asthma and of those 57.9 percent reported a history of having an asthma attack [2]. When treating asthma, remember that it is an airway geometry problem. Imagine the bronchioles are large milkshake straws, nice and large for low resistance airflow to move in and out. During an asthma attack, that mil... περισσότερα »
Elective Minimally Invasive &' Conventional Surgical Tracheostomy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Comparison of Elective Minimally Invasive with Conventional Surgical Tracheostomy in Adults: AbstractMinimally invasive techniques were used for tracheostomy including small horizontal skin incision, limited soft tissue dissection and no suturing. A Retrospective analysis of case sheets of patients who underwent elective tracheostomy by the first and second authors at M S Ramaiah Hospitals in Bangalore between 1st May 2010 and 1st May 2015 was done to compare the result of elective conventional open surgical tracheostomy using midline vertical skin incision with minimally invasive ...περισσότερα »
Effects of Chemoradiation on Hearing in Patients with Head and Neck Malignancies
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
: Experience at a Tertiary Referral Care Hospital: AbstractHearing loss as a side effect in patients with head and neck malignancies with chemoradiation is frequently ignored. Its effects on auditory functions are less studied and there are studies done on animals which are less reliable. The present study was undertaken to identify the type of hearing loss and also to quantify the degree of hearing loss in these patients. A prospective, descriptive study was undertaken in histologically proven head and neck cancer patients treated with cobalt 60 teletherapy who received a dose of ...περισσότερα »
Comparison of Elective Minimally Invasive with Conventional Surgical Tracheostomy in Adults
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Comparison of Elective Minimally Invasive with Conventional Surgical Tracheostomy in Adults: AbstractMinimally invasive techniques were used for tracheostomy including small horizontal skin incision, limited soft tissue dissection and no suturing. A Retrospective analysis of case sheets of patients who underwent elective tracheostomy by the first and second authors at M S Ramaiah Hospitals in Bangalore between 1st May 2010 and 1st May 2015 was done to compare the result of elective conventional open surgical tracheostomy using midline vertical skin incision with minimally invasive ...περισσότερα »
Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma: Summary Resistance to thyroid hormone (RTH) is a syndrome of reduced tissue responsiveness to thyroid hormones. RTH is majorly caused by mutations in the thyroid hormone receptor beta (*THRB*) gene. Recent studies indicated a close association of *THRB* mutations with human cancers, but the role of *THRB* mutation in carcinogenesis is still unclear. Here, we report a rare case of RTH with a papillary thyroid carcinoma (PTC). A 26-year-old woman was referred to our hospital due to a thyroid tumor and hormon...περισσότερα »
Efficacy of Elective Neck Dissection in T1/T2N0M0 Oral Tongue Squamous Cell Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
A Population-Based Analysis: Objective/Hypothesis The aim of this population-based study is to analyze the survival benefits of elective neck dissection (END) over neck observation in T1/T2N0M0 oral tongue squamous cell carcinoma (OT-SCC) cases. Study Design Retrospective administrative database analysis. Subjects and Methods The SEER database (Surveillance, Epidemiology, and End Results) was queried for patients diagnosed with T1/T2N0M0 OT-SCC from 1998 to 2011. Data included patient demographics, initial treatment, and survival outcomes. The Kaplan-Meier model and the Cox propor... περισσότερα »
Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation: Objectives To directly measure the spatial mapping in the olfactory bulb by odor presentation and by direct electrical stimulation. Study Design Experimental (animal). Setting University research laboratory. Subjects and Methods Odor (n = 8) and electrical stimulation (n = 4) of the olfactory bulb in rats were used to demonstrate the spatial mapping of neural responses in the olfactory bulb. Both multiunit responses to odor stimulation and evoked potential responses to localized electrical stimu... περισσότερα »
Impact of Middle versus Inferior Total Turbinectomy on Nasal Aerodynamics
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Impact of Middle versus Inferior Total Turbinectomy on Nasal Aerodynamics: Objectives This computational study aims to (1) use virtual surgery to theoretically investigate the maximum possible change in nasal aerodynamics after turbinate surgery, (2) quantify the relative contributions of the middle and inferior turbinates to nasal resistance and air conditioning, and (3) quantify to what extent total turbinectomy impairs the nasal air-conditioning capacity. Study Design Virtual surgery and computational fluid dynamics. Setting Academic tertiary medical center. Subjects and Meth... περισσότερα »
Pretreatment Hematologic Findings as Novel Predictive Markers for Facial Palsy Prognosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Pretreatment Hematologic Findings as Novel Predictive Markers for Facial Palsy Prognosis: Objective To examine the relationship between prognosis of 2 different facial palsies and pretreatment hematologic laboratory values. Study Design Multicenter case series with chart review. Setting Three tertiary care hospitals. Subjects and Methods We examined the clinical records of 468 facial palsy patients who were treated with an antiviral drug in combination with either oral or intravenous corticosteroids in participating hospitals between 2010 and 2014. Patients were divided into a B... περισσότερα »
MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs: Objective Cells, scaffold, and surgical approaches are important for regeneration of the lamina propria of the scarred vocal fold (VF). Microendoscopy of Reinke’s space (MERS) is a surgical approach used to access the lamina propria. The present study evaluated MERS in the treatment of VF scarring as compared with standardized approaches for the treatment of VF scarring with adipose stem cell constructs. Study Design Animal study. Setting Academic center. Subjects and Meth...περισσότερα »
Pathologic Changes of the Peripheral Vestibular System Secondary to Chronic Otitis Media
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Pathologic Changes of the Peripheral Vestibular System Secondary to Chronic Otitis Media: Objective To evaluate the histopathologic changes of dark, transitional, and hair cells of the vestibular system in human temporal bones from patients with chronic otitis media. Study Design Comparative human temporal bone study. Setting Otopathology laboratory. Subjects and Methods To compare the density of vestibular dark, transitional, and hair cells in temporal bones with and without chronic otitis media, we used differential interference contrast microscopy. Results In the chronic ot... περισσότερα »
Endoscopic Resection of Sinonasal Malignancy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
: A Systematic Review and Meta-analysis: Objectives The use of endoscopic approaches for sinonasal malignancy resection has increased, but survival data are limited secondary to disease rarity and new surgical technique. Here we present a systematic review and meta-analysis of endoscopic endonasal resection of sinonasal malignancy. Data Sources MEDLINE, PubMed Central, NCBI Bookshelf, Cochrane Library, clinicaltrials.gov, National Guideline Clearinghouse. Review Methods PRISMA/MOOSE guidelines were followed. MeSH terms were "endoscopic" AND ("esthesioneuroblastoma" OR "sinonasal a... περισσότερα »
Surgical Timing of the Orbital "Blowout" Fracture: A Systematic Review and Meta-analysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Surgical Timing of the Orbital "Blowout" Fracture: A Systematic Review and Meta-analysis: Objective The orbital blowout fracture is a common facial injury, carrying with it a risk of visual impairment and undesirable cosmetic results unless treated properly. Optimal timing of the surgical treatment is still a matter of debate. We set out to determine whether a meta-analysis would bring us closer to an answer to this question. Data Sources PubMed, EMBASE, Web of Science, and the Cochrane Library were searched from January 1980 to August 2014. We applied the following inclusion crite...περισσότερα »
Racial Differences of Pigmentation in the Human Vestibular Organs
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Racial Differences of Pigmentation in the Human Vestibular Organs: Objectives Melanin pigmentation is present in the human inner ear. In this study, we quantify the melanin pigmentation in the vestibular system and examine racial differences of vestibular melanin pigmentation using human cadaveric temporal bone specimens. Study Design Basic research. Setting Laboratory. Subjects and Methods Light microscopy was used to examine specimens from 40 left temporal bones from the Johns Hopkins Human Temporal Bone Collection. Color images of (1) ampulla of the horizontal canal, (2) utr... περισσότερα »
The Role of Electrode Placement in Bilateral Simultaneously Cochlear-Implanted Adult Patients
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
The Role of Electrode Placement in Bilateral Simultaneously Cochlear-Implanted Adult Patients: Objective To evaluate the influence of the electrode placement on hearing performance in adult patients who were simultaneously and bilaterally cochlear implanted. Study Design Case series with planned data collection. Setting Tertiary referral university centers. Subjects and Methods The postoperative computed tomography scan was studied for 19 patients who were simultaneously and bilaterally implanted with a long straight electrode array. The size of the cochlea was measured in consi... περισσότερα »
Functional Outcomes after Salvage Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Functional Outcomes after Salvage Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma: Objectives Transoral laser microsurgery (TLM) has been increasingly used in lieu of total laryngectomy to treat malignancy after definitive radiation. There are few data in the literature regarding functional outcomes. We retrospectively reviewed voice and swallowing outcomes in patients who underwent TLM for recurrent laryngeal carcinoma. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Forty-two patients were identified with recurr...περισσότερα »
Effect of Vocal Fold Medialization on Dysphagia in Patients with Unilateral Vocal Fold Immobility
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Effect of Vocal Fold Medialization on Dysphagia in Patients with Unilateral Vocal Fold Immobility: Objective The effect of vocal fold medialization (VFM) on vocal improvement in persons with unilateral vocal fold immobility (UVFI) is well established. The effect of VFM on the symptom of dysphagia is uncertain. The purpose of this study is to evaluate dysphagia symptoms in patients with UVFI pre- and post-VFM. Study Design Case series with chart review. Setting Academic tertiary care medical center. Subjects and Methods The charts of 44 persons with UVFI who underwent VFM between... περισσότερα »
Predictors of Failed and Delayed Decannulation after Head and Neck Surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Predictors of Failed and Delayed Decannulation after Head and Neck Surgery: Objective To determine the variables that are predictive of failed decannulation (FD), delayed decannulation (DD), and days to decannulation in patients who underwent head and neck cancer resection with free tissue transfer reconstruction for head and neck squamous cell carcinoma. Design Case series with chart review. Setting Tertiary care otolaryngology–head and neck surgery referral center. Subject and Methods Patients (N = 108) were included who underwent head and neck cancer resection with free tissu... περισσότερα »
Comprehensive Survey Results of Childhood Thyroid Ultrasound Examinations in Fukushima in the First Four Years After the Fukushima Daiichi Nuclear Power Plant Accident
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Comprehensive Survey Results of Childhood Thyroid Ultrasound Examinations in Fukushima in the First Four Years After the Fukushima Daiichi Nuclear Power Plant Accident: Author information Shinichi Suzuki,1,2 Satoru Suzuki,1,2 Toshihiko Fukushima,1,2 Sanae Midorikawa,1,3 Hiroki Shimura,1,4Takashi Matsuzuka,5 Tetsuo Ishikawa,1,6 Hideto Takahashi,1 Akira Ohtsuru,1,3 Akira Sakai,1,7 Mitsuaki Hosoya,1,8 Seiji Yasumura,1,9 Kenneth E. Nollet,1 Tetsuya Ohira,1,10 Hitoshi Ohto,1 Masafumi Abe,1Kenji Kamiya,1,11 and Shunichi Yamashita1,12 for the Fukushima Health Management Survey 1Radiation ... περισσότερα »
Building a Quality Management System for a Thyroid Nodule Clinic
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Building a Quality Management System for a Thyroid Nodule Clinic: [image: access_free.gif] Thyroid , Vol. 0, No. 0. Author information Alexandra L. Migdal,1 Scot B. Sternberg,2 Adebayo Oshin,2 Mark D. Aronson,3 and James V. Hennessey1 1Department of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 2Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 3Department of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts. Address correspondence to: *James Hennessey, MD* *Division of End...περισσότερα »
FTSG on the Face: Do We Really Need Tie-over Dressings or Quilting Sutures?
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 18 δευτερόλεπτα
[image: image]No abstract available from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T3XkOm via IFTTT
Aesthetic Total Reconstruction of Lower Eyelid Using Scapha Cartilage Graft on a Vascularized Propeller Flap
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 18 δευτερόλεπτα
[image: image]Background: The aim of this study was to review the results of a cohort of patients based on our experience with a new technique for total lower eyelid reconstruction after a large defect caused by malignant tumor and trauma. A scapha cartilage graft with small skin on a vascularized propeller flap was used for 16 cases requiring lower eyelid reconstruction. Methods: Patients were identified from a database, and a retrospective case note review was conducted. The scapha cartilage graft was sutured to the margin of the defect of the palpebral conjunctiva and tarsus. The... περισσότερα »
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 18 δευτερόλεπτα
[image: image]Summary: Pigmented villonodular synovitis (PVNS) is a rare and benign proliferative disorder of synovium with potentially locally aggressive growth and invasion of the bone. Occurring within the joints, tendon sheaths, and bursae, it is most commonly a monoarticular disease affecting large joints. In particular, most cases of PVNS occur in the knee. PVNS of the temporomandibular joint (TMJ) is a highly rare disorder, with approximately 60 cases reported. Herein, we present a unique case of an elderly male presenting with ear pain and subsequently diagnosed with PVNS of... περισσότερα »
No-drain DIEP Flap Donor-site Closure Using Barbed Progressive Tension Sutures
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 18 δευτερόλεπτα
[image: image]Background: The use of progressive tension sutures has been shown to be comparable to the use of abdominal drains in abdominoplasty. However, the use of barbed progressive tension sutures (B-PTSs) in deep inferior epigastric artery perforator (DIEP) flap donor-site closure has not been investigated. Methods: A retrospective chart review was performed on patients with DIEP flap reconstruction in a 3-year period at 2 institutions by 2 surgeons. Patients were compared by method of DIEP donor-site closure. Group 1 had barbed running progressive tension sutures without drai...περισσότερα »
Entrapment of the Flexor Digitorum Profundus in the Callus after a Closed Distal Radial Fracture
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 18 δευτερόλεπτα
[image: image]Summary: A 17-year-old boy sustained a closed distal radius fracture; a closed reduction and external fixation was performed. After failed rehabilitation for digital flexion restriction, a surgical exploration was decided, revealing entrapment of flexor digitorum profundus in the bony callus; tendons were freed, obtaining a full range of motion. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T3XkOc via IFTTT
30-year International Pediatric Craniofacial Surgery Partnership: Evolution from the “Third World” Forward
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 18 δευτερόλεπτα
[image: image]Background: Craniofacial diseases constitute an important component of the surgical disease burden in low- and middle-income countries. The consideration to introduce craniofacial surgery into such settings poses different questions, risks, and challenges compared with cleft or other forms of plastic surgery. We report the evolution, innovations, and challenges of a 30-year international craniofacial surgery partnership. Methods: We retrospectively report a partnership between surgeons at the Uniwersytecki Szpital Dzieciecy in Krakow, Poland, and a North American crani... περισσότερα »
MCA, Vol. 21, Pages 17: Three-Parameter Interval Grey Number Multi-Attribute Decision Making Method Based on Information Entropy
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 18 δευτερόλεπτα
Aimed at the situation that the plan attribute value is a three-parameter interval grey number and that attribute weight is uncertain, a three-parameter interval grey number multi-attribute decision making method based on information entropy is proposed. In this study, we combine the three-parameter interval grey number decision-making problem with information entropy, build the distance entropy model of the three-parameter interval grey number, and provide a solution to the empowerment problem of the three-parameter interval grey number in grey decision-making problems. On this b...περισσότερα »
Sustainability, Vol. 8, Pages 464: Towards a Model of Sustainable Competitiveness of Health Organizations
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 18 δευτερόλεπτα
Over the last decades, around the world, the concept of competitiveness was long debated by economists (and others), widely used and even sometimes overused. Although at the theoretical level, a number of determinant factors of health care organizations' competitiveness have been proposed, their diversity and the little empirical data available argues for the need to create and validate a model of competitiveness of health organizations. The purpose of this paper is (considering the theoretical approach) to shape a model of sustainable competitiveness of health organizations. In t... περισσότερα »
Effect of Vocal Fold Medialization on Dysphagia in Patients with Unilateral Vocal Fold Immobility
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objective The effect of vocal fold medialization (VFM) on vocal improvement in persons with unilateral vocal fold immobility (UVFI) is well established. The effect of VFM on the symptom of dysphagia is uncertain. The purpose of this study is to evaluate dysphagia symptoms in patients with UVFI pre- and post-VFM. Study Design Case series with chart review. Setting Academic tertiary care medical center. Subjects and Methods The charts of 44 persons with UVFI who underwent VFM between June 1, 2013, and December 31, 2014, were abstracted from a prospectively maintained database ...περισσότερα »
Functional Outcomes after Salvage Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objectives Transoral laser microsurgery (TLM) has been increasingly used in lieu of total laryngectomy to treat malignancy after definitive radiation. There are few data in the literature regarding functional outcomes. We retrospectively reviewed voice and swallowing outcomes in patients who underwent TLM for recurrent laryngeal carcinoma. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Forty-two patients were identified with recurrent squamous cell carcinoma of the larynx after definitive radiation therapy from 2001 to 2013: 28 ... περισσότερα »
The Role of Electrode Placement in Bilateral Simultaneously Cochlear-Implanted Adult Patients
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objective To evaluate the influence of the electrode placement on hearing performance in adult patients who were simultaneously and bilaterally cochlear implanted. Study Design Case series with planned data collection. Setting Tertiary referral university centers. Subjects and Methods The postoperative computed tomography scan was studied for 19 patients who were simultaneously and bilaterally implanted with a long straight electrode array. The size of the cochlea was measured in consideration of the major cochlear diameter and cochlear height. The electrode-to-modiolus dist...περισσότερα »
Racial Differences of Pigmentation in the Human Vestibular Organs
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objectives Melanin pigmentation is present in the human inner ear. In this study, we quantify the melanin pigmentation in the vestibular system and examine racial differences of vestibular melanin pigmentation using human cadaveric temporal bone specimens. Study Design Basic research. Setting Laboratory. Subjects and Methods Light microscopy was used to examine specimens from 40 left temporal bones from the Johns Hopkins Human Temporal Bone Collection. Color images of (1) ampulla of the horizontal canal, (2) utricular wall, (3) endolymphatic duct, and (4) posterior ampullary... περισσότερα »
Surgical Timing of the Orbital "Blowout" Fracture: A Systematic Review and Meta-analysis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objective The orbital blowout fracture is a common facial injury, carrying with it a risk of visual impairment and undesirable cosmetic results unless treated properly. Optimal timing of the surgical treatment is still a matter of debate. We set out to determine whether a meta-analysis would bring us closer to an answer to this question. Data Sources PubMed, EMBASE, Web of Science, and the Cochrane Library were searched from January 1980 to August 2014. We applied the following inclusion criteria: isolated blowout fractures, presenting early and late surgery groups (<14 and >14... περισσότερα »
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objectives The use of endoscopic approaches for sinonasal malignancy resection has increased, but survival data are limited secondary to disease rarity and new surgical technique. Here we present a systematic review and meta-analysis of endoscopic endonasal resection of sinonasal malignancy. Data Sources MEDLINE, PubMed Central, NCBI Bookshelf, Cochrane Library, clinicaltrials.gov, National Guideline Clearinghouse. Review Methods PRISMA/MOOSE guidelines were followed. MeSH terms were "endoscopic" AND ("esthesioneuroblastoma" OR "sinonasal adenocarcinoma" OR "squamous cell carc... περισσότερα »
Pathologic Changes of the Peripheral Vestibular System Secondary to Chronic Otitis Media
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objective To evaluate the histopathologic changes of dark, transitional, and hair cells of the vestibular system in human temporal bones from patients with chronic otitis media. Study Design Comparative human temporal bone study. Setting Otopathology laboratory. Subjects and Methods To compare the density of vestibular dark, transitional, and hair cells in temporal bones with and without chronic otitis media, we used differential interference contrast microscopy. Results In the chronic otitis media group (as compared with the age-matched control group), the density of type ... περισσότερα »
MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objective Cells, scaffold, and surgical approaches are important for regeneration of the lamina propria of the scarred vocal fold (VF). Microendoscopy of Reinke's space (MERS) is a surgical approach used to access the lamina propria. The present study evaluated MERS in the treatment of VF scarring as compared with standardized approaches for the treatment of VF scarring with adipose stem cell constructs. Study Design Animal study. Setting Academic center. Subjects and Methods VF injury was performed bilaterally to induce scarring in 20 pigs. Eight weeks after injury, pigs we... περισσότερα »
Pretreatment Hematologic Findings as Novel Predictive Markers for Facial Palsy Prognosis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objective To examine the relationship between prognosis of 2 different facial palsies and pretreatment hematologic laboratory values. Study Design Multicenter case series with chart review. Setting Three tertiary care hospitals. Subjects and Methods We examined the clinical records of 468 facial palsy patients who were treated with an antiviral drug in combination with either oral or intravenous corticosteroids in participating hospitals between 2010 and 2014. Patients were divided into a Bell's palsy group or a Hunt's palsy group. We used the Yanagihara facial nerve grading ... περισσότερα »
Impact of Middle versus Inferior Total Turbinectomy on Nasal Aerodynamics
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objectives This computational study aims to (1) use virtual surgery to theoretically investigate the maximum possible change in nasal aerodynamics after turbinate surgery, (2) quantify the relative contributions of the middle and inferior turbinates to nasal resistance and air conditioning, and (3) quantify to what extent total turbinectomy impairs the nasal air-conditioning capacity. Study Design Virtual surgery and computational fluid dynamics. Setting Academic tertiary medical center. Subjects and Methods Ten patients with inferior turbinate hypertrophy were studied. Thre... περισσότερα »
Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Abstract Background Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited. Methods We conducted a retrospective review of the National Cancer Database. Results Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with […]
Marine Drugs, Vol. 14, Pages 91: Effect of Chitosan Properties on Immunoreactivity
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
[image: ag] Chitosan is a widely investigated biopolymer in drug and gene delivery, tissue engineering and vaccine development. However, the immune response to chitosan is not clearly understood due to contradicting results in literature regarding its immunoreactivity. Thus, in this study, we analyzed effects of various biochemical properties, namely degree of deacetylation (DDA), viscosity/polymer length and endotoxin levels, on immune responses by antigen presenting cells (APCs). Chitosan solutions from various sources were treated with mouse and human APCs (macrophages and/or de...περισσότερα »
Sustainability, Vol. 8, Pages 463: System Merits or Failures? Policies for Transition to Sustainable P and N Systems in The Netherlands and Finland
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Nitrogen (N) and phosphorus (P) cycles are absolutely vital in maintaining sustainable food systems. Human activities disturb the natural balance of these cycles by creating enormous additional nutrient fluxes, causing eutrophication of waterways and pollution in land systems. To tackle this problem, sustainable nutrient management is required. This paper addresses sustainable nutrient management in two countries: The Netherlands and Finland. We adopt a critical perspective on resource politics, especially towards opportunistic policy strategies for the pollutant management of N a... περισσότερα »
Sensors, Vol. 16, Pages 674: Bootstrapping Security Policies for Wearable Apps Using Attributed Structural Graphs
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
We address the problem of bootstrapping security and privacy policies for newly-deployed apps in wireless body area networks (WBAN) composed of smartphones, sensors and other wearable devices. We introduce a framework to model such a WBAN as an undirected graph whose vertices correspond to devices, apps and app resources, while edges model structural relationships among them. This graph is then augmented with attributes capturing the features of each entity together with user-defined tags. We then adapt available graph-based similarity metrics to find the closest app to a new one ... περισσότερα »
Applied Sciences, Vol. 6, Pages 146: Tests and Analysis of the Compressive Performance of an Integrated Masonry Structure of a Brick-Stem-Insulating Layer
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
This paper proposes, for low buildings, an integrated wall structure of a brick-stem-insulating layer, which plays a major part in both heat preservation and force bearing. The research team has tested the thermal performance of the structure, the results of which are satisfying. To further study the force-bearing performance, the paper carries out compressive tests of specimens of different structural design, with two types of bricks, i.e., clay and recycled concrete bricks; three types of stems, i.e., square-shaped wood, square-shaped steel pipe and circular steel pipe; and one ... περισσότερα »
Nutrients, Vol. 8, Pages 277: A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women—A Randomized Controlled Trial
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Flavonoids and fish oils have anti-inflammatory and immune-modulating influences. The purpose of this study was to determine if a mixed flavonoid-fish oil supplement (Q-Mix; 1000 mg quercetin, 400 mg isoquercetin, 120 mg epigallocatechin (EGCG) from green tea extract, 400 mg n3-PUFAs (omega-3 polyunsaturated fatty acid) (220 mg eicosapentaenoic acid (EPA) and 180 mg docosahexaenoic acid (DHA)) from fish oil, 1000 mg vitamin C, 40 mg niacinamide, and 800 µg folic acid) would reduce complications associated with obesity; that is, reduce inflammatory and oxidative stress markers and ...περισσότερα »
Water, Vol. 8, Pages 196: The Status of Domestic Water Demand: Supply Deficit in the Kathmandu Valley, Nepal
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
United Nations Sustainable Development Goal 6 targets access to water and sanitation for all people in the next 15 years. However, for developing countries such as Nepal, it is more challenging to achieve this goal given its poor infrastructure and high population growth. To assess the water crisis in the most developed and populated area of Nepal, the Kathmandu Valley, we estimated available water resources and domestic water demand in the valley. We estimated a supply deficit of 102 million liters per day (MLD) in 2016, after completion of the first phase of the Melamchi Water S... περισσότερα »
Processes, Vol. 4, Pages 16: Process Intensification via Membrane Reactors, the DEMCAMER Project
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
This paper reports the findings of a FP7 project (DEMCAMER) that developed materials (catalysts and membranes) and new processes for four industrially relevant reaction processes. In this project, active, stable, and selective catalysts were developed for the reaction systems of interest and their production scaled up to kg scale (TRL5 (TRL: Technology Readiness Level)). Simultaneously, new membranes for gas separation were developed; in particular, dense supported thin palladium-based membranes for hydrogen separation from reactive mixtures. These membranes were successfully scale...περισσότερα »
MCA, Vol. 21, Pages 17: Three-Parameter Interval Grey Number Multi-Attribute Decision Making Method Based on Information Entropy
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Aimed at the situation that the plan attribute value is a three-parameter interval grey number and that attribute weight is uncertain, a three-parameter interval grey number multi-attribute decision making method based on information entropy is proposed. In this study, we combine the three-parameter interval grey number decision-making problem with information entropy, build the distance entropy model of the three-parameter interval grey number, and provide a solution to the empowerment problem of the three-parameter interval grey number in grey decision-making problems. On this b...περισσότερα »
Sustainability, Vol. 8, Pages 464: Towards a Model of Sustainable Competitiveness of Health Organizations
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Over the last decades, around the world, the concept of competitiveness was long debated by economists (and others), widely used and even sometimes overused. Although at the theoretical level, a number of determinant factors of health care organizations' competitiveness have been proposed, their diversity and the little empirical data available argues for the need to create and validate a model of competitiveness of health organizations. The purpose of this paper is (considering the theoretical approach) to shape a model of sustainable competitiveness of health organizations. In t... περισσότερα »
Current and future treatment of amyloid diseases
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Abstract There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or amyloidoses. These disorders are named after the characteristic cross-β-sheet amyloid fibrils that accumulate systemically or are localized to specific organs. In most cases, current treatment is limited to symptomatic approaches and thus disease-modifying therapies are needed. Alzheimer's disease is a neurodegenerative disorder with extracellular amyloid β-peptide (Aβ) fibrils and intracellular tau neurofibrillary tangles as pathological hallm... περισσότερα »
Predictors of Deceased Donor Kidney Discard in the United States.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 35 δευτερόλεπτα
Background: Renal transplantation is a lifesaving intervention for end-stage renal disease. The demand for renal transplantation outweighs the availability of organs; however, up to 20% of recovered kidneys are discarded before transplantation. We aimed to better characterize the risk factors for deceased donor kidney discard. Methods: We performed a secondary analysis of the Organ Procurement and Transplantation Network database from 2000 to 2012 of all solid organ donors. The cohort was split into training (80%) and validation (20%) subsets. We performed a stepwise logistic regres... περισσότερα »
First Report of Human Pancreas Transplantation Using IGL-1 Preservation Solution: A Case Series.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 35 δευτερόλεπτα
No abstract available from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/24JROEl via IFTTT
Inflammation in Early Kidney Allograft Surveillance Biopsies With and Without Associated Tubulointerstitial Chronic Damage as a Predictor of Fibrosis Progression and Development of De Novo Donor Specific Antibodies.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 35 δευτερόλεπτα
Background: Interstitial fibrosis and tubular atrophy (IFTA) associated with interstitial inflammation in nonscarred areas (IFTA+i) is associated with poorer graft outcome than inflammation without IFTA or IFTA without inflammation. Methods: We evaluated if histological categories at week 6 could predict the development of interstitial fibrosis and de novo donor specific anti-HLA antibodies (dnDSA) at 1 year. Biopsies were classified according to Banff criteria as normal (i+t=2 and ci+ct=2) or IFTA+i (i+t>=2 and ci+ct>=2). Results: We analyzed 598 standard immunological risk recipie... περισσότερα »
Chronic Rejection in Human Vascularized Composite Allotransplantation (Hand and Face Recipients): An Update.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 35 δευτερόλεπτα
Vascularized composite tissue allografts (VCA) have become a viable option to restore severely damaged parts of the body that cannot be repaired with conventional surgical techniques. Acute rejection develops frequently in the early postgraft period both in human and experimental VCA, but the possibility of human VCA to undergo chronic rejection (CR) remained initially unknown. The experience gained over the years shows that, similar to solid organ transplants (SOT), human VCA can also develop CR. Chronic rejection is clinically mostly apparent on the skin and targets preferentially... περισσότερα »
The Lymphatic Phenotype of Lung Allografts in Patients With Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 35 δευτερόλεπτα
Background: Chronic lung allograft dysfunction (CLAD), presenting as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS) is the major limiting factor of long-term survival in lung transplantation. Its pathogenesis is still obscure. In BOS, persistent alloimmune injury and chronic airway inflammation are suggested. One of the main tasks of the lymphatic vessel (LV) system is the promotion of immune cell trafficking. The formation of new LVs has been shown to trigger chronic allograft rejection in kidney transplants. We therefore sought to address the role ... περισσότερα »
Current and future treatment of amyloid diseases
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Abstract There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or amyloidoses. These disorders are named after the characteristic cross-β-sheet amyloid fibrils that accumulate systemically or are localized to specific organs. In most cases, current treatment is limited to symptomatic approaches and thus disease-modifying therapies are needed. Alzheimer's disease is a neurodegenerative disorder with extracellular amyloid β-peptide (Aβ) fibrils and intracellular tau neurofibrillary tangles as pathological hallm... περισσότερα »
Precision medicine in pheochromocytoma and paraganglioma: current and future concepts
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Abstract Pheochromocytoma and paraganglioma (PPGL) are rare diseases but are also amongst the most characterized tumour types. Hence, patients with PPGL have greatly benefited from precision medicine for more than two decades. According to current molecular biology and genetics-based taxonomy, PPGL can be divided into three different clusters characterized by: Krebs cycle reprogramming with oncometabolite accumulation or depletion (group 1a); activation of the (pseudo)hypoxia signalling pathway with increased tumour cell proliferation, invasiveness and migration (group 1b); and abe... περισσότερα »
Inhibition of TRPV1 prevented skin irritancy induced by phenoxyethanol. A preliminary in vitro and in vivo study
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 37 δευτερόλεπτα
Abstract Background Phenoxyethanol is a widely used preservative in personal care products. Transient Receptor Potential Vanilloid1 (TRPV1) on cell membrane is activated by TRPV1 agonist capsaicin resulting in an opening of the channel for calcium influx, which is linked with neurosensory sensations characterized by itching, burning and stinging of skin. Whether uncomfortable skin sensations caused by phenoxyethanol claimed by people having sensitive skin are also due to activation ofTRPV1 has not been reported in literature. Objective Aim of this study was to evaluate whether t... περισσότερα »
MCA, Vol. 21, Pages 17: Three-Parameter Interval Grey Number Multi-Attribute Decision Making Method Based on Information Entropy
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 38 δευτερόλεπτα
Aimed at the situation that the plan attribute value is a three-parameter interval grey number and that attribute weight is uncertain, a three-parameter interval grey number multi-attribute decision making method based on information entropy is proposed. In this study, we combine the three-parameter interval grey number decision-making problem with information entropy, build the distance entropy model of the three-parameter interval grey number, and provide a solution to the empowerment problem of the three-parameter interval grey number in grey decision-making problems. On this b...περισσότερα »
Sustainability, Vol. 8, Pages 464: Towards a Model of Sustainable Competitiveness of Health Organizations
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 38 δευτερόλεπτα
Over the last decades, around the world, the concept of competitiveness was long debated by economists (and others), widely used and even sometimes overused. Although at the theoretical level, a number of determinant factors of health care organizations' competitiveness have been proposed, their diversity and the little empirical data available argues for the need to create and validate a model of competitiveness of health organizations. The purpose of this paper is (considering the theoretical approach) to shape a model of sustainable competitiveness of health organizations. In t... περισσότερα »
Current and future treatment of amyloid diseases
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 38 δευτερόλεπτα
Abstract There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or amyloidoses. These disorders are named after the characteristic cross-β-sheet amyloid fibrils that accumulate systemically or are localized to specific organs. In most cases, current treatment is limited to symptomatic approaches and thus disease-modifying therapies are needed. Alzheimer's disease is a neurodegenerative disorder with extracellular amyloid β-peptide (Aβ) fibrils and intracellular tau neurofibrillary tangles as pathological hallm... περισσότερα »
Precision medicine in pheochromocytoma and paraganglioma: current and future concepts
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 38 δευτερόλεπτα
Abstract Pheochromocytoma and paraganglioma (PPGL) are rare diseases but are also amongst the most characterized tumour types. Hence, patients with PPGL have greatly benefited from precision medicine for more than two decades. According to current molecular biology and genetics-based taxonomy, PPGL can be divided into three different clusters characterized by: Krebs cycle reprogramming with oncometabolite accumulation or depletion (group 1a); activation of the (pseudo)hypoxia signalling pathway with increased tumour cell proliferation, invasiveness and migration (group 1b); and abe... περισσότερα »
KI researcher Tore Curstedt nominated for EPO Lifetime Achievement Award
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 45 δευτερόλεπτα
Docent Tore Curstedt at Karolinska Institutet's Department of Molecular Medicine and Surgery has been nominated by the European Patent Office (EPO) for a Lifetime Achievement Award at the 2016 European Inventor Award ceremony for his work with Corosurf. Tore Curstedt is nominated for the work he and his colleague Bengt Robertsson have done on their innovative treatment for preterm babies with respiratory distress syndrome (RDS). The method, which was introduced in 1989, has now been administered to over three million infants. The drug developed by Dr Curstedt is marketed under the...περισσότερα »
Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Abstract Background Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited. Methods We conducted a retrospective review of the National Cancer Database. Results Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with […]
Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Abstract Background Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited. Methods We conducted a retrospective review of the National Cancer Database. Results Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with […]
Hemodynamic Parameters during Laryngoscopic Procedures in the Office and in the Operating Room
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objective Previous research has shown that office-based laryngoscopic procedures can induce hemodynamic changes, including tachycardia and severe hypertension, calling into question the safety of these procedures. However, comparison between office and operating room (OR) procedures has not been carried out. Therefore, we prospectively measured hemodynamic variables in both settings to compare hemodynamic changes between office […]
Predictors of Failed and Delayed Decannulation after Head and Neck Surgery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objective To determine the variables that are predictive of failed decannulation (FD), delayed decannulation (DD), and days to decannulation in patients who underwent head and neck cancer resection with free tissue transfer reconstruction for head and neck squamous cell carcinoma. Design Case series with chart review. Setting Tertiary care otolaryngology–head and neck surgery referral center. […]
Effect of Vocal Fold Medialization on Dysphagia in Patients with Unilateral Vocal Fold Immobility
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objective The effect of vocal fold medialization (VFM) on vocal improvement in persons with unilateral vocal fold immobility (UVFI) is well established. The effect of VFM on the symptom of dysphagia is uncertain. The purpose of this study is to evaluate dysphagia symptoms in patients with UVFI pre- and post-VFM. Study Design Case series with […]
Functional Outcomes after Salvage Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objectives Transoral laser microsurgery (TLM) has been increasingly used in lieu of total laryngectomy to treat malignancy after definitive radiation. There are few data in the literature regarding functional outcomes. We retrospectively reviewed voice and swallowing outcomes in patients who underwent TLM for recurrent laryngeal carcinoma. Study Design Case series with chart review. Setting Tertiary […]
The Role of Electrode Placement in Bilateral Simultaneously Cochlear-Implanted Adult Patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objective To evaluate the influence of the electrode placement on hearing performance in adult patients who were simultaneously and bilaterally cochlear implanted. Study Design Case series with planned data collection. Setting Tertiary referral university centers. Subjects and Methods The postoperative computed tomography scan was studied for 19 patients who were simultaneously and bilaterally implanted with […]
Racial Differences of Pigmentation in the Human Vestibular Organs
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objectives Melanin pigmentation is present in the human inner ear. In this study, we quantify the melanin pigmentation in the vestibular system and examine racial differences of vestibular melanin pigmentation using human cadaveric temporal bone specimens. Study Design Basic research. Setting Laboratory. Subjects and Methods Light microscopy was used to examine specimens from 40 left […]
Surgical Timing of the Orbital «Blowout» Fracture: A Systematic Review and Meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objective The orbital blowout fracture is a common facial injury, carrying with it a risk of visual impairment and undesirable cosmetic results unless treated properly. Optimal timing of the surgical treatment is still a matter of debate. We set out to determine whether a meta-analysis would bring us closer to an answer to this question. […]
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Objectives The use of endoscopic approaches for sinonasal malignancy resection has increased, but survival data are limited secondary to disease rarity and new surgical technique. Here we present a systematic review and meta-analysis of endoscopic endonasal resection of sinonasal malignancy. Data Sources MEDLINE, PubMed Central, NCBI Bookshelf, Cochrane Library, clinicaltrials.gov, National Guideline Clearinghouse. Review Methods […]
Methodological questions regarding the burden of Healthcare-Associated Infections in Southeast Asia: the meta-analysis
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
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Retention in Care Among HIV-Infected Patients on Antiretroviral Therapy and Among Those Not on Antiretroviral Therapy in Eastern Africa
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
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Reply to Wang, et al.
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
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Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited. Methods We conducted a retrospective review of the National Cancer Database. Results Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with […]
Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
The action potential (AP) is a fundamental feature of excitable cells that serves as the basis for long-distance signaling in the nervous system. There is considerable diversity in the appearance of APs and the underlying repolarization mechanisms in different neuronal types (reviewed in Bean BP. *Nat Rev Neurosci* 8: 451–465, 2007), including among pyramidal cell subtypes. In the present work, we used specific pharmacological blockers to test for contributions of Kv1, Kv2, or Kv4 channels to repolarization of single APs in two genetically defined subpopulations of pyramidal cells ... περισσότερα »
Blocking trial-by-trial error correction does not interfere with motor learning in human walking
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Movements can be learned implicitly in response to new environmental demands or explicitly through instruction and strategy. The former is often studied in an environment that perturbs movement so that people learn to correct the errors and store a new motor pattern. Here, we demonstrate in human walking that implicit learning of foot placement occurs even when an explicit strategy is used to block changes in foot placement during the learning process. We studied people learning a new walking pattern on a split-belt treadmill with and without an explicit strategy through instructi... περισσότερα »
An asymmetric outer retinal response to drifting sawtooth gratings
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Electroretinogram (ERG) studies have demonstrated that the retinal response to temporally modulated fast-ON and fast-OFF sawtooth flicker is asymmetric. The response to spatiotemporal sawtooth stimuli has not yet been investigated. Perceptually, such drifting gratings or diamond plaids shaded in a sawtooth pattern appear brighter when movement produces fast-OFF relative to fast-ON luminance profiles. The neural origins of this illusion remain unclear (although a retinal basis has been suggested). Thus we presented toad eyecups with sequential epochs of sawtooth, sine-wave, and squ...περισσότερα »
Current and future treatment of amyloid diseases
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Abstract There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or amyloidoses. These disorders are named after the characteristic cross-β-sheet amyloid fibrils that accumulate systemically or are localized to specific organs. In most cases, current treatment is limited to symptomatic approaches and thus disease-modifying therapies are needed. Alzheimer's disease is a neurodegenerative disorder with extracellular amyloid β-peptide (Aβ) fibrils and intracellular tau neurofibrillary tangles as pathological hallm... περισσότερα »
Precision medicine in pheochromocytoma and paraganglioma: current and future concepts
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Abstract Pheochromocytoma and paraganglioma (PPGL) are rare diseases but are also amongst the most characterized tumour types. Hence, patients with PPGL have greatly benefited from precision medicine for more than two decades. According to current molecular biology and genetics-based taxonomy, PPGL can be divided into three different clusters characterized by: Krebs cycle reprogramming with oncometabolite accumulation or depletion (group 1a); activation of the (pseudo)hypoxia signalling pathway with increased tumour cell proliferation, invasiveness and migration (group 1b); and abe... περισσότερα »
Energy Cost of Walking, Symptomatic Fatigue and Perceived Exertion in Persons with Multiple Sclerosis
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 10 May 2016 *Source:*Gait & Posture Author(s): Linda H. Chung, Jillian Angelo, Richard E.A. van Emmerik, Jane A. Kent A higher energy cost of walking (Cw) is sometimes observed in MS, and could contribute to fatigue. The purpose of this study was to compare Cw at three speeds in MS and controls, and determine the effects of walking speed on fatigue and perceived exertion. We hypothesized that MS would have higher Cw, fatigue and exertion during walking than controls. Ten persons with MS and 14 controls of similar age and physical activity levels were...περισσότερα »
Three-dimensional evaluation of heel raise test in pediatric planovalgus feet and normal feet
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 10 May 2016 *Source:*Gait & Posture Author(s): Britta K. Krautwurst, Sebastian I. Wolf, Thomas Dreher Planovalgus foot is a common pediatric deformity which may be associated with pain. To evaluate flexibility of the foot, the heel raise test is used. During this test the arch and hindfoot are assessed. Several studies have described planovalgus foot based on 3D gait and standing analysis. However, no studies have evaluated foot flexibility during heel raise using an objective 3D analysis. Therefore, the purpose of this study is to evaluate the flexi... περισσότερα »
Energy Cost of Walking, Symptomatic Fatigue and Perceived Exertion in Persons with Multiple Sclerosis
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 10 May 2016 *Source:*Gait & Posture Author(s): Linda H. Chung, Jillian Angelo, Richard E.A. van Emmerik, Jane A. Kent A higher energy cost of walking (Cw) is sometimes observed in MS, and could contribute to fatigue. The purpose of this study was to compare Cw at three speeds in MS and controls, and determine the effects of walking speed on fatigue and perceived exertion. We hypothesized that MS would have higher Cw, fatigue and exertion during walking than controls. Ten persons with MS and 14 controls of similar age and physical activity levels were...περισσότερα »
Three-dimensional evaluation of heel raise test in pediatric planovalgus feet and normal feet
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 10 May 2016 *Source:*Gait & Posture Author(s): Britta K. Krautwurst, Sebastian I. Wolf, Thomas Dreher Planovalgus foot is a common pediatric deformity which may be associated with pain. To evaluate flexibility of the foot, the heel raise test is used. During this test the arch and hindfoot are assessed. Several studies have described planovalgus foot based on 3D gait and standing analysis. However, no studies have evaluated foot flexibility during heel raise using an objective 3D analysis. Therefore, the purpose of this study is to evaluate the flexi... περισσότερα »
Energy Cost of Walking, Symptomatic Fatigue and Perceived Exertion in Persons with Multiple Sclerosis
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 10 May 2016 *Source:*Gait & Posture Author(s): Linda H. Chung, Jillian Angelo, Richard E.A. van Emmerik, Jane A. Kent A higher energy cost of walking (Cw) is sometimes observed in MS, and could contribute to fatigue. The purpose of this study was to compare Cw at three speeds in MS and controls, and determine the effects of walking speed on fatigue and perceived exertion. We hypothesized that MS would have higher Cw, fatigue and exertion during walking than controls. Ten persons with MS and 14 controls of similar age and physical activity levels were...περισσότερα »
Three-dimensional evaluation of heel raise test in pediatric planovalgus feet and normal feet
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 10 May 2016 *Source:*Gait & Posture Author(s): Britta K. Krautwurst, Sebastian I. Wolf, Thomas Dreher Planovalgus foot is a common pediatric deformity which may be associated with pain. To evaluate flexibility of the foot, the heel raise test is used. During this test the arch and hindfoot are assessed. Several studies have described planovalgus foot based on 3D gait and standing analysis. However, no studies have evaluated foot flexibility during heel raise using an objective 3D analysis. Therefore, the purpose of this study is to evaluate the flexi... περισσότερα »
Association of Genetic Risk for Schizophrenia With Nonparticipation Over Time in a Population-Based Cohort Study
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
Progress has recently been made in understanding the genetic basis of schizophrenia and other psychiatric disorders. Longitudinal studies are complicated by participant dropout, which could be related to the presence of psychiatric problems and associated genetic risk. We tested whether common genetic variants implicated in schizophrenia were associated with study nonparticipation among 7,867 children and 7,850 mothers from the Avon Longitudinal Study of Parents and Children (ALSPAC; 1991–2007), a longitudinal population cohort study. Higher polygenic risk scores for schizophrenia...περισσότερα »
A tribute to the life and career of Holbrook Kohrt
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
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Oncolytic immunotherapy: an emerging new modality for the treatment of cancer
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
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Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες
Objectives To directly measure the spatial mapping in the olfactory bulb by odor presentation and by direct electrical stimulation. Study Design Experimental (animal). Setting University research laboratory. Subjects and Methods Odor (n = 8) and electrical stimulation (n = 4) of the olfactory bulb in rats were used to demonstrate the spatial mapping of neural responses in the olfactory bulb. Both multiunit responses to odor stimulation and evoked potential responses to localized electrical stimulation were measured in different regions of the olfactory bulb. Results Respons... περισσότερα »
Efficacy of Elective Neck Dissection in T1/T2N0M0 Oral Tongue Squamous Cell Carcinoma: A Population-Based Analysis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες
Objective/Hypothesis The aim of this population-based study is to analyze the survival benefits of elective neck dissection (END) over neck observation in T1/T2N0M0 oral tongue squamous cell carcinoma (OT-SCC) cases. Study Design Retrospective administrative database analysis. Subjects and Methods The SEER database (Surveillance, Epidemiology, and End Results) was queried for patients diagnosed with T1/T2N0M0 OT-SCC from 1998 to 2011. Data included patient demographics, initial treatment, and survival outcomes. The Kaplan-Meier model and the Cox proportional hazards model were ... περισσότερα »
A controlled study of use of patient-reported outcomes to improve assessment of late effects after treatment for head-and-neck cancer
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*Radiotherapy and Oncology Author(s): Trille Kjaer, Susanne Oksbjerg Dalton, Elo Andersen, Randi Karlsen, Anni Linnet Nielsen, Merete Kjaer Hansen, Kirsten Frederiksen, Christoffer Johansen Background and purposeTo test the effect of longitudinal feedback on late effects reported by survivors of head-and-neck cancer (HNC) to clinicians during regular follow-up.Material and methodsA total of 266 participants were sequentially assigned to either control or intervention group and filled in electronic versions of the EORTC QLQ C-30, H...περισσότερα »
Automatic segmentation of breast in prone position: Correlation of similarity indexes and breast pendulousness with dose/volume parameters
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*Radiotherapy and Oncology Author(s): Giovanna Dipasquale, Xinzhuo Wang, Vanessa Chatelain-Fontanella, Vincent Vinh-Hung, Raymond Miralbell This study evaluates edited/reviewed automatically-segmented structures of the breast target in patients planned in prone position and their dose/volume effects. Contouring times were reduced using automatic-segmentation. Similarity-indexes and pendulousness showed that targets with Dice values over 0.965 and high pendulousness, presented the best dosimetric results. from Rathiotherapy via ...περισσότερα »
Cancer cell motility is affected through 3D cell culturing and SCF/c-Kit pathway but not by X-irradiation
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*Radiotherapy and Oncology Author(s): Fabian Eberle, Miriam F. Saulich, Florian H. Leinberger, Werner Seeger, Rita Engenhart-Cabillic, Ekkehard Dikomey, Jörg Hänze, Katja Hattar, Florentine S.B. Subtil Background and purposeSuccess of radiotherapy is often limited by therapy resistance and metastasis resulting from cancer cell motility. It was tested in vitro whether this cancer cell motility is affected by growth condition, active SCF/c-Kit pathway or X-irradiation.Materials and methodsCell motility was measured with BioCoat™ Mat...περισσότερα »
The price of robustness; impact of worst-case optimization on organ-at-risk dose and complication probability in intensity-modulated proton therapy for oropharyngeal cancer patients
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*Radiotherapy and Oncology Author(s): Steven van de Water, Iris van Dam, Dennis R. Schaart, Abrahim Al-Mamgani, Ben J.M. Heijmen, Mischa S. Hoogeman PurposeTo quantify the impact of the degree of robustness against setup errors and range errors on organ-at-risk (OAR) dose and normal tissue complication probabilities (NTCPs) in intensity-modulated proton therapy for oropharyngeal cancer patients.Material and methodsFor 20 oropharyngeal cases (10 unilateral and 10 bilateral), robust treatment plans were generated using ‘minimax’ wor... περισσότερα »
Dosimetric analysis of upper gastrointestinal ulcer after carbon-ion radiotherapy for pancreatic cancer
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*Radiotherapy and Oncology Author(s): Makoto Shinoto, Yoshiyuki Shioyama, Akira Matsunobu, Kei Okamoto, Hiroaki Suefuji, Shingo Toyama, Hiroshi Honda, Sho Kudo PurposeThe aim of this study was to clarify the incidence, clinical risk factors, and dose–volume relationship of upper gastrointestinal (GI) ulcer after carbon-ion radiotherapy (C-ion RT) for pancreatic cancer.Materials and methodsFifty-eight pancreatic cancer patients were treated with C-ion RT from April 2014 to December 2015. The total dose was 55.2Gy (RBE) in 12 fracti... περισσότερα »
Performance of automatic image segmentation algorithms for calculating total lesion glycolysis for early response monitoring in non-small cell lung cancer patients during concomitant chemoradiotherapy
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*Radiotherapy and Oncology Author(s): Willem Grootjans, Edwin A. Usmanij, Wim J.G. Oyen, Erik H.F.M. van der Heijden, Eric P. Visser, Dimitris Visvikis, Mathieu Hatt, Johan Bussink, Lioe-Fee de Geus-Oei Background and purposeThis study evaluated the use of total lesion glycolysis (TLG) determined by different automatic segmentation algorithms, for early response monitoring in non-small cell lung cancer (NSCLC) patients during concomitant chemoradiotherapy.Materials and methodsTwenty-seven patients with locally advanced NSCLC treat...περισσότερα »
Identification of a rectal subregion highly predictive of rectal bleeding in prostate cancer IMRT
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 9 May 2016 *Source:*Radiotherapy and Oncology Author(s): Gaël Dréan, Oscar Acosta, Juan D. Ospina, Auréline Fargeas, Caroline Lafond, Gwenaelle Corrégé, Jean-L. Lagrange, Gilles Créhange, Antoine Simon, Pascal Haigron, Renaud de Crevoisier Background and purposeTo identify rectal subregions at risks (SRR) highly predictive of 3-year rectal bleeding (RB) in prostate cancer IMRT.Materials and methodsOverall, 173 prostate cancer patients treated with IMRT/IGRT were prospectively analyzed, divided into “training” (n=118) and “validation” cohorts (n=53). ... περισσότερα »
Dynamically-enhanced retention of gold nanoclusters in HeLa cells following X-rays exposure: A cell cycle phase-dependent targeting approach
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 9 May 2016 *Source:*Radiotherapy and Oncology Author(s): Yan Liu, Weiqiang Chen, Pengcheng Zhang, Xiaodong Jin, Xinguo Liu, Ping Li, Feifei Li, Hongpeng Zhang, Guozhang Zou, Qiang Li Background and purposeCell cycle phase could affect the cellular uptake of nanoparticles. Based on the fact that ionizing radiation exposure can delay cell cycle progression including inducing G2/M phase arrest, we propose that ionizing radiation exposure is a cell cycle phase-dependent targeting approach for intracellular delivery of nano-agents in tumor cells.Materials ... περισσότερα »
Lung stereotactic body radiotherapy with an MR-linac – Quantifying the impact of the magnetic field and real-time tumor tracking
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 8 May 2016 *Source:*Radiotherapy and Oncology Author(s): Martin J. Menten, Martin F. Fast, Simeon Nill, Cornelis P. Kamerling, Fiona McDonald, Uwe Oelfke Background and purposeThere are concerns that radiotherapy doses delivered in a magnetic field might be distorted due to the Lorentz force deflecting secondary electrons. This study investigates this effect on lung stereotactic body radiotherapy (SBRT) treatments, conducted either with or without multileaf collimator (MLC) tumor tracking.Material and methodsLung SBRT treatments with an MR-linac were...περισσότερα »
Evaluation of four-dimensional computed tomography (4D-CT)-based pulmonary ventilation: The high correlation between 4D-CT ventilation and 81mKr-planar images was found
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 8 May 2016 *Source:*Radiotherapy and Oncology Author(s): Takayuki Kanai, Noriyuki Kadoya, Kengo Ito, Kazuma Kishi, Suguru Dobashi, Takaya Yamamoto, Rei Umezawa, Haruo Matsushita, Ken Takeda, Keiichi Jingu PurposeTo evaluate four-dimensional computed tomography (4D-CT)-derived pulmonary ventilation by comparing with 81mKr-gas ventilation (VRI). We also proposed two methods to improve the functional accuracy of 4D-CT ventilation images and evaluated these methods.Methods and materialsEleven lung cancer patients with 4D-CT and VRI were analyzed. Hounsfi... περισσότερα »
Salvage high-dose-rate brachytherapy for locally recurrent prostate cancer after primary radiotherapy failure
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 8 May 2016 *Source:*Radiotherapy and Oncology Author(s): Piotr Wojcieszek, Marta Szlag, Grzegorz Głowacki, Agnieszka Cholewka, Marzena Gawkowska-Suwińska, Sylwia Kellas-Ślęczka, Brygida Białas, Marek Fijałkowski Background and purposeTo evaluate high-dose-rate brachytherapy (HDR BT) as a salvage modality for locally recurrent prostate cancer after primary radiotherapy failure.Materials and methodsEighty-three prostate cancer patients, who locally relapsed after radiotherapy, were treated with salvage HDR BT. The schedule was three implantations, ever... περισσότερα »
Quality-of-life after radiotherapy for advanced laryngeal cancer: Results of a phase III trial of the Dutch Head and Neck Society
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 8 May 2016 *Source:*Radiotherapy and Oncology Author(s): Geert O. Janssens, Johannes A. Langendijk, Chris H. Terhaard, Patricia A. Doornaert, Piet van den Ende, Martin A. de Jong, Robert P. Takes, Paul N. Span, Johannes H. Kaanders Background/purposeTo report on health-related quality-of-life (HRQoL) of patients with laryngeal cancer, treated in a randomized trial comparing accelerated radiotherapy with carbogen and nicotinamide (ARCON) against accelerated radiotherapy alone (AR).Material/methodsHRQoL was assessed using the HRQoL Questionnaire-C30 (Q... περισσότερα »
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The last decade witnessed the emergence of genomics, a set of high-throughput molecular measurements in biological samples. These pan-genomic and agnostic approaches have revolutionized the molecular biology and genetics of malignant and benign tumors. These techniques have been applied successfully to adrenocortical tumors. Exome sequencing identified new major drivers in all tumor types, including KCNJ5, […]
Enhanced detection of single-cell-secreted proteins
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
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Minimally invasive corticotomy in orthodontics using a three-dimensional printed CAD/CAM surgical guide
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 10 May 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): M. Cassetta, M. Giansanti, A. Di Mambro, S. Calasso, E. Barbato The aim of this prospective study was to evaluate the effectiveness of an innovative, minimally invasive, flapless corticotomy procedure in orthodontics. The STROBE guidelines were followed. Ten patients with […]
Minimally invasive corticotomy in orthodontics using a three-dimensional printed CAD/CAM surgical guide
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): M. Cassetta, M. Giansanti, A. Di Mambro, S. Calasso, E. Barbato The aim of this prospective study was to evaluate the effectiveness of an innovative, minimally invasive, flapless corticotomy procedure in orthodontics. The STROBE guidelines were followed. Ten patients with severe dental crowding and a class I molar relationship were selected to receive orthodontic treatment with clear aligners and corticotomy-facilitated orthodontics. The mean age of these patient... περισσότερα »
Minimally invasive corticotomy in orthodontics using a three-dimensional printed CAD/CAM surgical guide
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 May 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): M. Cassetta, M. Giansanti, A. Di Mambro, S. Calasso, E. Barbato The aim of this prospective study was to evaluate the effectiveness of an innovative, minimally invasive, flapless corticotomy procedure in orthodontics. The STROBE guidelines were followed. Ten patients with severe dental crowding and a class I molar relationship were selected to receive orthodontic treatment with clear aligners and corticotomy-facilitated orthodontics. The mean age of these patients ... περισσότερα »
Introducing Academic Emergency Medicine Education and Training
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 2 ώρες
We are excited to announce the birth of a new journal dedicated to emergency medicine educational scholarship. The new journal will be called *Academic Emergency Medicine Education and Training (AEM A&T)*. As of June 16 2016, *Academic Emergency Medicine* will no longer review or accept manuscripts that center on education or training of emergency care providers. Instead, we will offer the manuscript's authors a choice of either having the paper reviewed for possible publication in the new journal, *Academic Emergency Medicine Education and Training* or the option of withdrawing t... περισσότερα »
Vibrationally Resolved Absorption and Fluorescence Spectra of Firefly Luciferin: A Theoretical Simulation in the Gas Phase and in Solution
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες
Abstract Firefly bioluminescence has been applied in several fields. However, the absorption and fluorescence spectra of the substrate, luciferin, have not been observed at the vibrational level. In the current study, the vibrationally resolved absorption and fluorescence spectra of firefly luciferin (neutral form LH2, phenolate-ion form LH- and dianion form L2-) are simulated using the density functional method and convoluted by a Gaussian function, with displacement, distortion and Duschinsky effects in the framework of the Franck-Condon approximation. Both neutral and anionic f... περισσότερα »
OptiPhy, a technical-economic optimisation model for improving the management of plant protection practices in agriculture: a decision-support tool for controlling the toxicity risks related to pesticides
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες
Abstract The health, environmental and socio-economic issues related to the massive use of plant protection products are a concern for all the stakeholders involved in the agricultural sector. These stakeholders, including farmers and territorial actors, have expressed a need for decision-support tools for the management of diffuse pollution related to plant protection practices and their impacts. To meet the needs expressed by the public authorities and the territorial actors for such decision-support tools, we have developed a technical-economic model "OptiPhy" for risk mitigatio... περισσότερα »
Levels and distribution of polybrominated diphenyl ethers in the aquatic and terrestrial environment around a wastewater treatment plant
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες
Abstract The distribution and fate of polybrominated diphenyl ethers (PBDEs) in a riparian ecosystem nearby a wastewater treatment plant effluent were investigated. Different aqueous and terrestrial samples such as soil, sediment, plants, and invertebrates were collected and analyzed for tri- to heptabrominated PBDEs. Furthermore, the food web structure was elucidated using stable carbon and nitrogen isotopes. The highest PBDE levels were found for sediment- and soil-dwelling invertebrates, such as earthworms (Σ13 PBDEs 144 ng/g lipid weight), *Tubifex tubifex* (77 ng/g lw), and sc... περισσότερα »
Coastal erosion as a source of mercury into the marine environment along the Polish Baltic shore
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες
Abstract The climate changes in recent years in the southern Baltic have been resulting in an increased frequency of natural extreme phenomena (i.e. storms, floods) and intensification of abrasion processes, which leads to introduction of large amounts of sedimentary deposits into the marine environment. The aim of this study was to determine the mercury load introduced to the Baltic Sea with deposits crumbling off the cliffs—parts of the coast that are the most exposed to abrasion. The studies were carried out close to five cliffs located on the Polish coast in the years 2011–201... περισσότερα »
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