Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τρίτη 17 Μαΐου 2016

OtoRhinoLaryngology & Medicine,New Articles,May 18th,2016


The predictive roles of neural oscillations in speech motor adaptability

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 4 δευτερόλεπτα
The human speech system exhibits a remarkable flexibility by adapting to alterations in speaking environments. While it is believed that speech motor adaptation under altered sensory feedback involves rapid reorganization of speech motor networks, the mechanisms by which different brain regions communicate and coordinate their activity to mediate adaptation remain unknown, and explanations of outcome differences in adaption remain largely elusive. In this study, under the paradigm of altered auditory feedback with continuous EEG recordings, the differential roles of oscillatory ne... περισσότερα »

Incorporating spike-rate adaptation into a rate code in mathematical and biological neurons

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 4 δευτερόλεπτα
For a slowly varying stimulus, the simplest relationship between a neuron's input and output is a rate code, in which the spike rate is a unique function of the stimulus at that instant. In the case of spike-rate adaptation, there is no unique relationship between input and output, because the spike rate at any time depends both on the instantaneous stimulus and on prior spiking (the "history"). To improve the decoding of spike trains produced by neurons that show spike-rate adaptation, we developed a simple scheme that incorporates "history" into a rate code. We utilized this rat... περισσότερα »

ON and OFF inhibition as mechanisms for forward masking in the inferior colliculus: a modeling study

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 4 δευτερόλεπτα
Masking effects of a preceding stimulus on the detection or perception of a signal have been found in several sensory systems in mammals, including humans and rodents. In the auditory system, it has been hypothesized that a central "OFF-inhibitory" mechanism, which is generated by neurons that respond after a sound is terminated, may contribute to the observed psychophysics. The present study constructed a systems model for the inferior colliculus that includes major ascending monaural and binaural auditory pathways. The fundamental characteristics of several neuron types along th...περισσότερα »

Modulation of critical brain dynamics using closed-loop neurofeedback stimulation

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 4 δευτερόλεπτα
Several lines of electrophysiological (Linkenkaer-Hansen et al., 2001), blood-oxygenation-level dependent (BOLD) signal imaging (Bullmore et al. 2004) and behavioral (Gilden et al., 1995; Palva et al., 2013) evidence show that many features of central-nervous system activity in vivo are scale-free. The absence of specific scale (scale free) is a common attribute of self-similar processes or objects meaning that their properties remain similar at any scale (Hardstone et al, 2012). Scale-free dynamics is relevant because it is a signature characteristic of complex systems poised at cr... περισσότερα »

Comprehensive electrophysiology in leprous neuropathy – Is there a clinico-electrophysiological dissociation?

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 4 δευτερόλεπτα
Leprosy is a chronic granulomatous infection of skin and nerves caused by Mycobacterium leprae. It is the most common cause of acquired infectious neuropathy in the world, with India accounting for the maximum number of new cases of leprosy (Global leprosy situation, 2012). Though the skin manifestations cause unsightly dyspigmented patches, nodules, and deformed facial features (leonine facies), it is the nerve involvement that causes the maximum amount of disability in the form of loss of motor functions, skin ulcers, corneal ulcers, or major deformities of the limbs. from Physiol... περισσότερα »

Effect of Acute Exercise on Fatigue in People with ME/CFS/SEID: A Meta-analysis.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: A prominent symptom of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, or Systemic Exertion Intolerance Disease (ME/CFS/SEID) is persistent fatigue that is worsened by physical exertion. Here the population effect of a single bout of exercise on fatigue symptoms in people with ME/CFS/SEID was estimated and effect moderators were identified. Methods: Google Scholar was systematically searched for peer-reviewed articles published between February 1991 and May 2015. Studies were included where people diagnosed with ME/CFS/SEID and matched control participants completed a ... περισσότερα »

Strategic Priorities for Physical Activity Surveillance in the United States.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: Develop strategic priorities to guide future physical activity surveillance in the United States. Methods: The Centers for Disease Control and Prevention and the American College of Sports Medicine convened a Scientific Roundtable of physical activity and measurement experts. Participants summarized the current state of aerobic physical activity surveillance for adults, focusing on practice and research needs in three areas: 1) behavior, 2) human movement, and 3) community supports. Needs and challenges for each area were identified. At the conclusion of the meeting, expert...περισσότερα »

Increased Visual Utilization in Chronic Ankle Instability: A Meta-analysis.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: The underlying cause of balance impairments in chronic ankle instability (CAI) patients remains unknown but an altered utilization of sensory information has been hypothesized as a potential cause. The purpose of this systematic review with meta-analysis was to determine if CAI patients utilize somatosensory information to the same extent as uninjured controls during static single limb stance. Method: We searched PubMed, CINAHL, SPORTDiscus, and Scopus databases from origin to March 2016 using the combination of key words including: postural control, postural stability, sin...περισσότερα »

Contralateral Repeated Bout Effect of Eccentric Exercise of the Elbow Flexors.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: This study compared the magnitude of the repeated bout effect for different time intervals between two bouts of eccentric exercise of the elbow flexors to better understand the contralateral repeated bout effect (CL-RBE). Methods: Untrained young men (22.0 +/- 1.8 y) were allocated to either a control or one of seven CL-RBE groups (n=13/group). The CL-RBE groups performed exercise consisting of 30 maximal isokinetic (30[degrees]/s) eccentric contractions of the elbow flexors (ECC1) with either dominant or non-dominant arm followed 0.5 (0.5h), 6 (6h), 12 (12h) and 24 hours (... περισσότερα »

High-Intensity Interval Training on Cognitive and Mental Health in Adolescents.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: Emerging literature suggests that physical activity and fitness may have a positive impact on cognitive and mental health for adolescents. The purpose of the current study was to evaluate the efficacy of two high intensity interval training (HIIT) protocols for improving cognitive and mental health outcomes (executive function, psychological wellbeing, psychological distress and physical self-concept) in adolescents. Methods: Participants (n=65; mean age=15.8+/-0.6) were randomized to three conditions: aerobic exercise program (AEP; n=21), resistance and aerobic exercise pr... περισσότερα »

A Cluster RCT to Reduce Office Workers' Sitting Time: Impact on Activity Outcomes.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: To evaluate, compared to usual practice, the initial and long-term effectiveness of a workplace intervention targeting reducing sitting on activity outcomes. Methods: Office worksites (>=1km apart) from a single organization in Victoria, Australia were cluster randomized to intervention (n=7) or control (n=7). Participants were 231 desk-based office workers (5 to 39 participants per worksite) working at least 0.6 full time equivalent. The workplace-delivered intervention addressed organizational, physical environment, and individual behavioural change to reduce sitting time.... περισσότερα »

Neutrophil Depletion Attenuates Muscle Injury following Exhaustive Exercise.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
PURPOSE: The infiltration of macrophages in skeletal muscle during exhaustive exercise promotes inflammation, myofiber lesion, and muscle injury. Although neutrophils upregulate macrophage infiltration in skeletal muscles during exercise, the role of neutrophils in promoting muscle injury following exhaustive exercise remains unclear. In this study, we investigated the effects of pre-exercise neutrophil depletion with anti-neutrophil antibody treatment on muscle injury, inflammation, and macrophage infiltration following exhaustive exercise. METHODS: Male C57BL/6J mice were randomly... περισσότερα »

Fitness during Breast Cancer Treatment and Recovery in an Athlete: A Case Study.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: This is a case study of an aerobically trained, multi-sport, female athlete (age = 39) diagnosed with stage IIIc human epidermal growth factor receptor 2 positive breast cancer. The focus of the study is on measures of cardiorespiratory fitness (VO2peak) through the course of cancer therapy. Methods: A symptom-limited cardiopulmonary exercise tolerance test was performed to determine VO2peak. The test were performed at 5 different time points; 1) at diagnosis of breast cancer and prior to initiating chemotherapy, 2) after completion of chemotherapy (5-months post diagnosis)... περισσότερα »

Intensity-dependent Contribution of Neuromuscular Fatigue after Constant-Load Cycling.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
Purpose: We tested the hypothesis that central and peripheral fatigue after constant-load cycling exercise would vary with exercise intensity and duration. Methods: Twelve, well-trained male cyclists (V[Combining Dot Above]O2max, 4.49+/-0.35 L[middle dot]min-1) completed three constant-load cycling trials to the limit of tolerance in a randomized, crossover design. Exercise intensities were set according to the respiratory responses to a preliminary ramp test to elicit cardiorespiratory and metabolic responses consistent with exercise in the severe and heavy exercise domains; 1) at ... περισσότερα »

Head Impact Biomechanics in Women's College Soccer.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 6 δευτερόλεπτα
INTRODUCTION: There are limited non-laboratory soccer head impact biomechanics data. This is surprising given soccer's global popularity. Epidemiological data suggest female college soccer players are at a greater concussion injury risk than their male counterparts. Therefore, the purpose of our study was to quantify head impact frequency and magnitude during NCAA women's soccer practices and games, and to characterize these data across event type, playing position, year on the team, and segment of game (first and second halves). METHODS: Head impact biomechanics were collected from...περισσότερα »

Correlation of gender and age with magnetic resonance imaging findings in patients with arthrogenic temporomandibular disorders: a cross-sectional study

Publication date: Available online 17 May 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): R.deO. Lazarin, I.T.S. Previdelli, R.dosS. Silva, L.C.V. Iwaki, E. Grossmann, L.I. Filho The objective of this study was to analyse the correlation between the gender and age of individuals with arthrogenic temporomandibular disorders (TMDs) and magnetic resonance imaging (MRI) findings. […]

DNA Hypomethylation in Intestinal Cancer

DNA hypomethylation can prevent intestinal tumorigenesis, presumably by reducing epigenetic silencing of tumor-suppressor genes. A study in this issue by Sheaffer et al. challenges this notion by showing that severe DNA hypomethylation by tissue-specific Dnmt1 knockout can actually promote intestinal adenoma formation. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Tj6O4M via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos […]

Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP , presen ilins and APOE ε4

Abstract In this study, we used resting-state functional magnetic resonance imaging to explore the genetic effects of amyloid precursor protein (APP) or presenilins mutation and apolipoprotein E (APOE) ε4 on the default-mode network (DMN) in cognitively intact young adults (24.1 ± 2.5 years). Both the APP or presenilin-1/2 group and the APOE ε4 group had […]

Meningitis

Meningitis: Inflammation of the meninges, the three membranes that envelop the brain and the spinal cord. Meningitis can be caused by infection by bacteria, viruses, and protozoa. Other causes include cancer (metastasis to the meninges), inflammatory diseases, and drugs. In some cases the cause of meningitis cannot be determined. The treatment depends on the cause […]

Cathodal Transcranial Direct Current Stimulation (tDCS) to the Right Cerebellar Hemisphere Affects Motor Adaptation During Gait

Abstract The cerebellum appears to play a key role in the development of internal rules that allow fast, predictive adjustments to novel stimuli. This is crucial for adaptive motor processes, such as those involved in walking, where cerebellar dysfunction has been found to increase variability in gait parameters. Motor adaptation is a process that results […]

Methylation-mediated downregulation of long noncoding RNA LOC100130476 in gastric cardia adenocarcinoma

Abstract Accumulating evidences indicate that long non-coding RNAs (lncRNAs) play important roles in several biological processes and dysregulated lncRNAs are involved in different kinds of cancer and are associated with carcinogenesis, metastasis, and prognosis of cancer. The role of a new lncRNA LOC100130476 in gastric cardia adenocarcinoma (GCA) has remained unknown. The present study investigated […]

Minimal residual disease in breast cancer: an overview of circulating and disseminated tumour cells

Abstract Within the field of cancer research, focus on the study of minimal residual disease (MRD) in the context of carcinoma has grown exponentially over the past several years. MRD encompasses circulating tumour cells (CTCs)—cancer cells on the move via the circulatory or lymphatic system, disseminated tumour cells (DTCs)—cancer cells which have escaped into a […]

An Experimental Study of Risk Taking Behavior Among Adolescents: A Closer Look at Peer and Sex Influences

In this experimental study, it was examined to what extent peers and sex were important predictors of risk taking behavior of adolescents. Participants were 140 Dutch adolescents (52.9% boys, 12-15 years) who completed the Balloon Analogue Risk Task (BART) as a measure of risk taking behavior, either individually or in the presence of homogenous or […]

Adverse Event Reporting for Proton Pump Inhibitor Therapy: An Overview of Systematic Reviews

Objective To assist clinicians in counseling patients regarding the risk of adverse events from proton pump inhibitors (PPIs), by synthesizing evidence from published systematic reviews of antireflux therapy. Data Sources Cochrane Library, CINAHL, PubMed, Web of Knowledge. Review Methods Overview based on PRISMA reporting standards (preferred reporting items for systematic reviews and meta-analyses) of English-language […]

Same-Day Evaluation and Surgery for Otitis Media and Tympanostomy Tube Placement: A Feasibility Study

Objective To determine the feasibility of providing streamlined same-day evaluation and surgical management of children with recurrent otitis media or chronic serous otitis media who meet criteria for tympanostomy tube (TT) placement. Study Design Retrospective matched case series. Setting Tertiary care children’s hospital. Methods A comparison group (age, sex, insurance product) was utilized to determine […]

Leisure-Time Physical Activity and the Risk of Suspected Bacterial Infections.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 14 δευτερόλεπτα
Introduction: The risk of upper-respiratory tract viral infections is reduced with increased physical activity, but little information is available regarding bacterial infections. We examined the relationship between leisure-time physical activity and suspected bacterial infections. Methods: Information on leisure-time physical activity was obtained from the 2007 and 2010 North Denmark Region Health Surveys of 18,874 Danes and linked to data from nationwide administrative registries. Suspected bacterial infections were determined based on filled prescriptions for antibiotics. Adjust... περισσότερα »

The Relation of Arm Exercise Peak Heart Rate to Stress Test Results and Outcome.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 14 δευτερόλεπτα
Purpose: Arm exercise is an alternative to pharmacologic stress testing for >50% of patients unable to perform treadmill exercise but no data exist regarding the effect of attained peak arm exercise heart rate on test sensitivity. Thus, the purpose of this investigation was to characterize the relationship of peak arm exercise heart rate responses to abnormal stress test findings, coronary revascularization, and mortality in patients unable to perform leg exercise. Methods: From 1997 until 2002 arm cycle ergometer stress tests were performed in 443 consecutive veterans aged 64.1(11.... περισσότερα »

Ischemic Preconditioning and Repeated Sprint Swimming: A Placebo and Nocebo Study.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 14 δευτερόλεπτα
Purpose: Ischemic preconditioning (IPC) has been shown to improve performance of exercises lasting 10-90 s (anaerobic) and more than 90 s (aerobic). However, its effect on repeated sprint performance has been controversial, placebo effect has not been adequately controlled, and nocebo effect has not been avoided. Thus, the IPC effect on repeated sprint performance was investigated using a swimming task and controlling placebo/nocebo effects. Methods: Short-distance university swimmers were randomized to two groups. One group [n = 15, 24 +/- 1 years (mean +/- SEM)] was exposed to IPC... περισσότερα »

A Randomized Trial on the Effect of Exercise Mode on Breast Cancer-related Lymphedema.

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 14 δευτερόλεπτα
Purpose: Breast cancer-related lymphedema is a common and debilitating side effect of cancer treatment. This randomized trial compared the effect of progressive resistance- or aerobic-based exercise on breast cancer-related lymphedema extent and severity, as well as participants' muscular strength and endurance, aerobic fitness, body composition, upper-body function and quality of life. Methods: Women with a clinical diagnosis of stable unilateral, upper-limb lymphedema secondary to breast cancer were randomly allocated to a resistance- (n=21) or aerobic-based (n=20) exercise group ...περισσότερα »

The predictive roles of neural oscillations in speech motor adaptability

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 14 δευτερόλεπτα
The human speech system exhibits a remarkable flexibility by adapting to alterations in speaking environments. While it is believed that speech motor adaptation under altered sensory feedback involves rapid reorganization of speech motor networks, the mechanisms by which different brain regions communicate and coordinate their activity to mediate adaptation remain unknown, and explanations of outcome differences in adaption remain largely elusive. In this study, under the paradigm of altered auditory feedback with continuous EEG recordings, the differential roles of oscillatory ne... περισσότερα »

Incorporating spike-rate adaptation into a rate code in mathematical and biological neurons

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 14 δευτερόλεπτα
For a slowly varying stimulus, the simplest relationship between a neuron's input and output is a rate code, in which the spike rate is a unique function of the stimulus at that instant. In the case of spike-rate adaptation, there is no unique relationship between input and output, because the spike rate at any time depends both on the instantaneous stimulus and on prior spiking (the "history"). To improve the decoding of spike trains produced by neurons that show spike-rate adaptation, we developed a simple scheme that incorporates "history" into a rate code. We utilized this rat... περισσότερα »

ON and OFF inhibition as mechanisms for forward masking in the inferior colliculus: a modeling study

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 14 δευτερόλεπτα
Masking effects of a preceding stimulus on the detection or perception of a signal have been found in several sensory systems in mammals, including humans and rodents. In the auditory system, it has been hypothesized that a central "OFF-inhibitory" mechanism, which is generated by neurons that respond after a sound is terminated, may contribute to the observed psychophysics. The present study constructed a systems model for the inferior colliculus that includes major ascending monaural and binaural auditory pathways. The fundamental characteristics of several neuron types along th...περισσότερα »

Correlation of gender and age with magnetic resonance imaging findings in patients with arthrogenic temporomandibular disorders: a cross-sectional study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
Publication date: Available online 17 May 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): R.deO. Lazarin, I.T.S. Previdelli, R.dosS. Silva, L.C.V. Iwaki, E. Grossmann, L.I. Filho The objective of this study was to analyse the correlation between the gender and age of individuals with arthrogenic temporomandibular disorders (TMDs) and magnetic resonance imaging (MRI) findings.… Continue reading Correlation of gender and age with magnetic resonance imaging findings in patients with arthrogenic temporomandibular disorders: a cross-sectional study

Sociodemographics Affect Treatment, Outcome of Advanced Laryngeal Cancer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
In patients with advanced laryngeal cancer, younger patients and those residing in a county with a low median household income are more likely to receive surgical therapy, and females and married patients are at a lower risk of dying from cancer. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Tn1Asr via IFTTT

The predictive value of fall assessment tools for patients admitted to hospice care

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
Objectives Fall assessment tools are commonly used to evaluate the likelihood of fall. For patients found to be at high risk, patient-specific fall prevention interventions are implemented. The purposes of this study were to describe the population, evaluate and compare the efficacy of fall assessment tools, and suggest the best use for these tools in… Continue reading The predictive value of fall assessment tools for patients admitted to hospice care

Good concordance between patients and their non-professional carers about factors associated with a ‘good death and other important end-of-life decisions

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
Objectives The aim of this study was to investigate concordance between patients and non-professional carers about factors associated with a ‘good death’ and other end-of-life decisions. Methods Patients completed a questionnaire about end-of-life care issues, and were asked to rank the importance of factors linked to a ‘good death’. Carers also completed a questionnaire about… Continue reading Good concordance between patients and their non-professional carers about factors associated with a ‘good death and other important end-of-life decisions

Aqueous ozone solutions for pesticide removal from potatoes

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
The presence of pesticide residues in potatoes is of concern because of the potential impact to human health due to the high consumption of this vegetable. In this study, aqueous solutions with and without ozone saturation as postharvest wash treatment at pH 4.0, 7.0, and 9.0 were tested to remove chlorothalonil from potatoes. The method… Continue reading Aqueous ozone solutions for pesticide removal from potatoes

Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome Cell Biology

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
The proteasome has pronounced preferences for the amino-acid sequence of its substrates at the site at which it initiates degradation. Here, we report that modulating these sequences can tune the steady-state abundance of proteins over two orders of magnitude in cells. This is the same dynamic range as seen for inducing ubiquitination through a classic… Continue reading Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome Cell Biology

EACMFS Prizes and Awards

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
The Council of EACMFS wishes to ensure that all members of the Association are aware of the current awards and prizes that are available. These are designed to provide educational support and also to allow the opportunity for trainees and those who have recently achieved specialist status to visit units outside their own departments. from… Continue reading EACMFS Prizes and Awards

Clinical and Pathologic Predictors of Lymph Node Metastasis and Recurrence in Papillary Thyroid Microcarcinoma

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 25 δευτερόλεπτα
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1qsOn5M via IFTTT

Perceptions of coping with non-disease-related life stress for women with osteoarthritis: a qualitative analysis

Objective Coping with arthritis-related stress has been extensively studied. However, limited evidence exists regarding coping with stress extraneous to the disease (life stress). This study explored life stress and coping in a subset of older women with osteoarthritis from a larger longitudinal study. Setting An Australian regional university. Design This qualitative study involved semistructured telephone […]

Nationwide population-based cohort study of uterine rupture in Belgium: results from the Belgian Obstetric Surveillance System

Objectives We aimed to assess the prevalence of uterine rupture in Belgium and to evaluate risk factors, management and outcomes for mother and child. Design Nationwide population-based prospective cohort study. Setting Emergency obstetric care. Participation of 97% of maternity units covering 98.6% of the deliveries in Belgium. Participants All women with uterine rupture in Belgium […]

Determinants of adherence to seasonal influenza vaccination among healthcare workers from an Italian region: results from a cross-sectional study

Objectives Notwithstanding decades of efforts to increase the uptake of seasonal influenza (flu) vaccination among European healthcare workers (HCWs), the immunisation rates are still unsatisfactory. In order to understand the reasons for the low adherence to flu vaccination, a study was carried out among HCWs of two healthcare organisations in Liguria, a region in northwest […]

Geographical variation in glaucoma prescribing trends in England 2008-2012: an observational ecological study

Objectives To explore (1) the national trend in population-adjusted prescription rates for glaucoma and ocular hypertension (OHT) in England and (2) any geographical variation in glaucoma/OHT prescribing trends and its association with established risk factors for primary open-angle glaucoma (POAG) at the population level. Design Observational ecological study. Setting Primary care in England 2008–2012. Participants […]

Prevalence and trends of sensitisation to aeroallergens in patients with allergic rhinitis in Guangzhou, China: a 10-year retrospective study

Objective To investigate the prevalence and trends of sensitisation to common aeroallergens among outpatients with allergic rhinitis (AR) in Guangzhou, China, over the past decade. Design A retrospective study; linear-by-linear association and simple linear regression were used to determine the trends in the prevalence of aeroallergen sensitisation. Setting One grade-A hospital in Guangzhou, the largest […]

Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial

Introduction Despite recommendations that pregnant women increase their docosahexaenoic acid (DHA) intake to support fetal brain development, a recent systematic review found a lack of high-quality data to support the long-term effects of DHA supplementation on children’s neurodevelopment. Methods and analysis We will assess child neurodevelopment at 7 years of age in follow-up of a […]

Service factors causing delay in specialist assessment for TIA and minor stroke: a qualitative study of GP and patient perspectives

Objective To understand how service factors contribute to delays to specialist assessment following transient ischaemic attack (TIA) or minor stroke. Design Qualitative study using semistructured interviews, analysis by constant comparison. Setting Leicester, UK. Participants Patients diagnosed with TIA or minor stroke, at hospital admission or in a rapid-access TIA clinic (n=42), general practitioners (GPs) of […]

Correction

Tucker KL, Sheppard JP, Stevens R, et al. Individual patient data meta-analysis of selfmonitoring of blood pressure (BP-SMART): a protocol. BMJ Open 2015;5:e008532. The affiliation for Professor Gianfranco Parati, a co-author on this paper, is incorrect and should be: Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano, Milan, Italy & […]

Tunnelled haemodialysis catheter and haemodialysis outcomes: a retrospective cohort study in Zagreb, Croatia

Objectives Studies have reported that the tunnelled dialysis catheter (TDC) is associated with inferior haemodialysis (HD) patient survival, in comparison with arteriovenous fistula (AVF). Since many cofactors may also affect survival of HD patients, it is unclear whether the greater risk for survival arises from TDC per se, or from associated conditions. Therefore, the aim […]

Effects of Fatty Acid Synthase Inhibition by Orlistat on Proliferation of Endometrial Cancer Cell Lines

Abstract Objective Fatty acid synthase (FAS) is a key lipogenic enzyme that is highly expressed in endometrial cancer. Orlistat is a weight loss medication that has been shown to be a potent inhibitor of FAS. The goal of this study was to evaluate the anti-tumorigenic potential of orlistat in endometrial cancer cell lines. Methods The […]

Adverse Event Reporting for Proton Pump Inhibitor Therapy: An Overview of Systematic Reviews

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective To assist clinicians in counseling patients regarding the risk of adverse events from proton pump inhibitors (PPIs), by synthesizing evidence from published systematic reviews of antireflux therapy. Data Sources Cochrane Library, CINAHL, PubMed, Web of Knowledge. Review Methods Overview based on PRISMA reporting standards (preferred reporting items for systematic reviews and meta-analyses) of English-language… Continue reading Adverse Event Reporting for Proton Pump Inhibitor Therapy: An Overview of Systematic Reviews

Same-Day Evaluation and Surgery for Otitis Media and Tympanostomy Tube Placement: A Feasibility Study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective To determine the feasibility of providing streamlined same-day evaluation and surgical management of children with recurrent otitis media or chronic serous otitis media who meet criteria for tympanostomy tube (TT) placement. Study Design Retrospective matched case series. Setting Tertiary care children’s hospital. Methods A comparison group (age, sex, insurance product) was utilized to determine… Continue reading Same-Day Evaluation and Surgery for Otitis Media and Tympanostomy Tube Placement: A Feasibility Study

Dystonia-Causing Mutations as a Contribution to the Etiology of Spasmodic Dysphonia

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective Spasmodic dysphonia is a focal dystonia of the larynx with heterogeneous manifestations and association with familial risk factors. There are scarce data to allow precise understanding of etiology and pathophysiology. Screening for dystonia-causing genetic mutations has the potential to allow accurate diagnosis, inform about genotype-phenotype correlations, and allow a better understanding of mechanisms of… Continue reading Dystonia-Causing Mutations as a Contribution to the Etiology of Spasmodic Dysphonia

Improving Access to Head and Neck Cancer Surgical Services through the Incorporation of Associate Providers

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective The urgent nature of head and neck cancer referrals often results in overbooked schedules, access delays, and patient, physician, and staff dissatisfaction. The goal of this study is to examine how incorporation of associate providers (APs) into a head and neck tumor clinic (HNTC) can improve access. Methods Scheduling data for the Dartmouth-Hitchcock HNTC… Continue reading Improving Access to Head and Neck Cancer Surgical Services through the Incorporation of Associate Providers

Psychometric Validation of a Moroccan Version of the 22-Item Sino-Nasal Outcome Test

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective The objective of this study paper was to culturally adapt and validate the 22-item Sino-Nasal Outcome Test (SNOT-22) questionnaire for Moroccan Arabic speaking patients. Study Design Prospective cohort study. Setting Tertiary referral center; Ibn Rochd University Hospital, Casablanca, Morocco. Subjects and Methods The SNOT-22 was conducted in patients with chronic rhinosinusitis (CRS) undergoing sinonasal… Continue reading Psychometric Validation of a Moroccan Version of the 22-Item Sino-Nasal Outcome Test

The Use of Ibuprofen in Posttonsillectomy Analgesia and Its Effect on Posttonsillectomy Hemorrhage Rate

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective To determine the effect of ibuprofen on posttonsillectomy bleeding when compared with codeine in posttonsillectomy analgesia. Study Design Case series with chart review. Setting Tertiary care children’s hospital, Philadelphia, Pennsylvania. Subjects and Methods On July 1, 2012, our institution transitioned from acetaminophen with codeine to ibuprofen for posttonsillectomy analgesia. Pediatric patients (0-18 years old)… Continue reading The Use of Ibuprofen in Posttonsillectomy Analgesia and Its Effect on Posttonsillectomy Hemorrhage Rate

Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective To investigate the efficacy, safety, and microbiology of a thermosensitive otic suspension of ciprofloxacin (OTO-201) in children with bilateral middle ear effusion undergoing tympanostomy tube placement. Study Design Two randomized, double-blind, sham-controlled phase 3 trials. Patients were randomized to intratympanic OTO-201 or sham. Setting Children with bilateral middle ear effusion undergoing tympanostomy tube placement.… Continue reading Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes

Clinical and Pathologic Predictors of Lymph Node Metastasis and Recurrence in Papillary Thyroid Microcarcinoma

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1qsOn5M via IFTTT

GSE81527 IRAK4_hPBMC_stimulus_compound_exp3

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Contributor : Carman Julie Series Type : Expression profiling by array Organism : Homo sapiens The goal of this experiment is to characterize the ability of IRAK4 kinase inhibitors to block TLR7 or TLR9 induced gene transcription in human PBMCs. PBMCs from two donors were pretreated with compound for 30 minutes and stimulated with gardiquimod… Continue reading GSE81527 IRAK4_hPBMC_stimulus_compound_exp3

GSE81515 Effect of demeclocycline on brain tumor initiating cells

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Contributors : V W Yong ; Y Li ; S Sarkar Series Type : Expression profiling by array Organism : Homo sapiens We have determined that demeclocycline reduces the growth of brain tumor initiating cells (BTICs). Specifically, we sought to obtain insights into the mechanisms by which demeclocycline directly regulates BTIC growth. Analysis of the… Continue reading GSE81515 Effect of demeclocycline on brain tumor initiating cells

The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness

The haptoglobin 2-2 genotype is associated with atherosclerosis in type 2 diabetes mellitus. We examined the associations of the haptoglobin 2-2 genotype with C-reactive protein (high-sensitivity C-reactive protein) and carotid artery intima-media thickness, adjusting for age, gender, ethnicity, type 2 diabetes mellitus, smoking status, body mass index, blood pressure, glycated haemoglobin, non-high-density lipoprotein cholesterol and […]

Repair of a juxtarenal abdominal aortic aneurysm in a patient with situs inversus totalis using a retroperitoneal approach

Situs inversus totalis (SIT) is a rare condition characterized by the mirror image location of all of the thoracic and abdominal organs. There are only a handful of reports documenting the presence and repair of an abdominal aortic aneurysm (AAA) in the setting of SIT. Here, we present a rare case of a juxtarenal AAA […]

Complex aortic and bilateral renal artery aneurysms repair in a young patient with multiple arterial aneurysm syndrome

Aneurysmal disease affecting the aorta and visceral vessels in young patients is uncommon, and typically associated to connective tissue disorders. We describe the case of a 17 year-old female who presented with acute onset of abdominal pain; computed tomography (CT) scan revealed an aortic and bilateral renal artery aneurysms and a perirenal hematoma. She was […]

Endograft limb trimming and re-sheathing can be an alternative for emergent aortic repair without adequate stent graft availability

Endograft limb trimming can be an easy customization to perform in some emergent setups and in lack of alternative adequate covered stents. A male aged 74 presented with aortoenteric fistula and hemodynamic instability years after an aorto-bifemoral bypass, and a 56 year-old female was admitted with acute ischemia due to an aortic ulcer-like lesion. In […]

Splenic scintigraphy for further differentiation of unclear 68Ga-DOTATOC-PET/CT findings: Strengths and limitations

Summary Splenic scintigraphy has been described to be a powerful tool in unclear 68 Ga-DOTATOC-PET/CT findings, allowing differentiation between somatostatin receptor (Sst)-positive tissue deriving from neuroendocrine tumour (NET) and functioning splenic tissue. However, our own experiences sometimes show a lack of identification on splenic scintigraphy, especially in small lesions, leading to uncertainties regarding the safe […]

Unexplained Bowel Obstruction Presenting in a Premature Neonate Born to a Mother with HELLP Syndrome

Publication date: Available online 17 May 2016 Source:Journal of Pediatric Surgery Case Reports Author(s): Javier Otero, Abi James, Ian Thomas Cohen, William Boyan from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/24YDyrr via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Blunt Cardiac Rupture in a Toddler

Publication date: Available online 17 May 2016 Source:Journal of Pediatric Surgery Case Reports Author(s): Peep Talving, Mari-Liis Ilmoja, Günter Taal, Karl-Gunnar Isand, Sandra Teppo, Erast-Henri Noor, Rein Kruusat, Andrus Remmelgas, Sten Saar Blunt cardiac rupture is typically a fatal injury with overall mortality exceeding 90%. Most of the patients never reach a hospital alive. In […]

Chemosensitivity enhancement toward arsenic trioxide by inhibition of histone deacetylase in NB4 cell line

Objective To investigate the cytotoxic effects of suberanilohydroxamic acid (vorinostat) in combination with arsenic trioxide (ATO) on the human NB4 cell line in vitro. Methods The rates of cell proliferation following treatment with vorinostat with or without ATO were measured. Flow cytometry of Annexin-V/propidium iodide double-stained cells was used to measure apoptosis. Acridine Orange and […]

Clinical and Pathologic Predictors of Lymph Node Metastasis and Recurrence in Papillary Thyroid Microcarcinoma

Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/2049ZBu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method

Although pituitary thyrotropin (TSH) and thyroid hormones are physiologically interrelated, interpretation of measurements is conventionally done separately. Classification of subclinical thyroid dysfunction depends by definition solely on an abnormal TSH. This study examines a composite multivariate approach to disease classification. Methods Bivariate and trivariate reference limits were derived from a thyroid-healthy control group (n=271) and […]

Standardization of Guidelines for Patient Photograph Deidentification

Importance: This work was performed to advance patient care by protecting patient anonymity. Objectives: This study aimed to analyze the current practices used in patient facial photograph deidentification and set forth standardized guidelines for improving patient autonomy that are congruent with medical ethics and Health Insurance Portability and Accountability Act. Design: The anonymization guidelines of […]

Anatomic Basis for Penis Transplantation: Cadaveric Microdissection of Penile Structures

Abstract: We present a cadaveric dissection study to investigate the anatomic feasibility of penile transplantation. Seventeen male cadavers were dissected to reveal detailed anatomy of the dorsal neurovascular structures including dorsal arteries, superficial and deep dorsal veins, and dorsal nerves of the penis. Dorsal artery diameters showed a significant decrease from proximal to distal shaft. […]

A New Way for Antihelixplasty in Prominent Ear Surgery: Modified Postauricular Fascial Flap

Background: Otoplasty procedures aim to reduce the concha-mastoid angle and recreate the antihelical fold. Here, we explained the modified postauricular fascial flap, described as a new way for recreating the antihelical fold, and reported the results of patients on whom this flap was used. Materials and Methods: The defined technique was used on 24 patients […]

Redefining Vascular Anatomy of Posterior Tibial Artery Perforators: A Cadaveric Study and Review of the Literature

Introduction: Perforator flaps whether in a free or pedicled form are essential in leg reconstruction, requiring meticulous dissection based on a detailed understanding of vascular topographic anatomy. Numerous investigators have addressed this issue. However, the directionality of their fascial exit has not been greatly discussed in the literature. Subfascial course of the perforating vessel is […]

Osteoectomy in Rhinoplasty: A New Concept in Nasal Bones Repositioning

Background: Modern techniques of osteotomy have evolved to take into account the effects of bony repositioning on functional as well as aesthetic outcomes. Although a variety of methods have been described to appropriately mobilize and reposition the bony nasal vault, there is still no single procedure that can successfully manage nasal bones in its entirety. […]

Predictors of Mastectomy Flap Necrosis in Patients Undergoing Immediate Breast Reconstruction: A Review of 718 Patients

Background: Mastectomy flap necrosis (MFN) after mastectomy and immediate breast reconstruction can compromise postsurgical recovery, lead to additional surgeries, and compromise aesthetic outcome. The objective of this study was to determine if there is a difference in the rate of MFN in patients undergoing immediate alloplastic versus immediate autologous breast reconstruction. The secondary objective was […]

Arm Volumetry Versus Upper Extremity Lymphedema Index: Validity of Upper Extremity Lymphedema Index for Body-Type Corrected Arm Volume Evaluation

Background: Volumetry, measurement of extremity volume, is a commonly used method for upper extremity lymphedema (UEL) evaluation. However, comparison between different patients with different physiques is difficult with volumetry, because body-type difference greatly affects arm volume. Methods: Seventy arms of 35 participants who had no history of arm edema or breast cancer were evaluated. Arm […]

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