Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Article Neutrophil elastase cleaves thrombin generating anti-inflammatory peptides. Here the authors show that cleavage of thrombin by Pseudomonas aeruginosa elastase generates a peptide that prevents TLR dimerization and signaling, interfering with the inflammatory response to avoid host defense. Nature Communications doi: 10.1038/ncomms11567 Authors: Mariena J. A. van der Plas, Ravi K. V. Bhongir, Sven Kjellström, […]
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Article Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al . show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastasis. Nature Communications doi: 10.1038/ncomms11581 Authors: Noel P. Fusté, Rita Fernández-Hernández, […]
Does Preprocedural Ultrasound Increase the First-Pass Success Rate of Epidural Catheterization Before Cesarean Delivery? A Randomized Controlled Trial.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
BACKGROUND: Preprocedural ultrasound may improve the efficacy and safety of epidural catheterization, especially in difficult cases. Most studies of ultrasound-assisted epidural catheterization in the obstetric population are dated and nonblinded with inconsistent designs. This double-blind, randomized controlled study aimed to compare the ultrasound-assisted with the conventional palpation techniques for epidural catheterization in parturients undergoing cesarean […]
Continuing the Terra Firma and Establishing a New EQUATOR for Anesthesia & Analgesia.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TUp04h via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Advanced Uses of Pulse Oximetry for Monitoring Mechanically Ventilated Patients.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Pulse oximetry is an undisputable standard of care in clinical monitoring. It combines a spectrometer to detect hypoxemia with a plethysmograph for the diagnosis, monitoring, and follow-up of cardiovascular diseases. These pulse oximetry capabilities are extremely useful for assessing the respiratory and circulatory status and for monitoring of mechanically ventilated patients. On the one hand, […]
Replicability, Reproducibility, and Fragility of Research Findings-Ultimately, Caveat Emptor.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TkUlA3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Die Zirkumzision im kulturellen Spannungsfeld
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
„The first cut is the deepest?“ Die Zirkumzision ist die häufigste Operation im Kindesalter und bis heute auch die am heftigsten kontrovers diskutierte. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OzkBHR via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Do we really need sugammadex as an antagonist of muscle relaxants in anesthesia?.
Do we really need sugammadex as an antagonist of muscle relaxants in anesthesia?.: Purpose of review: Sugammadex is a selective relaxant-binding agent that is designed to encapsulate rocuronium and chemically similar steroidal muscle relaxants such as vecuronium. This review summarizes recent information on the use of sugammadex in clinical practice. Recent findings: The main advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and its unique ability to reverse rapidly and efficiently, for the first time, deep levels of n...περισσότερα »
Use of a home positive airway pressure device
during intraoperative monitored anesthesia care for outpatient surgery: AbstractPerioperative positive airway pressure (PAP) is recommended by the American Society of Anesthesiologists for patients with obstructive sleep apnea, but a readily available and personalized intraoperative delivery system does not exist. We present the successful use of a patient’s own nasal PAP machine in the operating room during outpatient foot surgery which required addition of a straight adaptor for oxygen delivery and careful positioning of the gas sampling line to permit end-tidal carbox dioxide m... περισσότερα »
Air-Qsp and i-Gel for airway management under general anesthesia with a muscle relaxant
Comparison of the clinical performances of [image: gr1.sml] Recently, i-Gel intubating laryngeal airway (ILA) has been frequently used because of the ease for airway insertion by residents and young anesthesiologists. However, it sometimes fails to fit or ventilate sufficiently in Japanese patients. Use of Air-Qsp, which is a new non-inflatable cuffed ILA, in a clinical setting has become possible. The purpose of this study was to compare the clinical performance of Air-Qsp with that of i-Gel for airway management in Japanese adult patients. Highlights - •We compared t... περισσότερα »
Use of a modified McGRATH MAC and tracheal tube introducer for difficult nasal intubation
Use of a modified McGRATH MAC and tracheal tube introducer for difficult nasal intubation: [image: article_notepad.gif] We report a case of difficult nasal tracheal tube intubation in which a tracheal tube introducer was used in conjunction with a modified McGRATH MAC video laryngoscope (McGRATH; Aircraft Medical Ltd, UK). The combination was effective in a patient with a reconstructed large tongue after resection of cancer of the floor of the mouth.
Excess nasopharyngeal secretions under propofol-based total intravenous anesthesia
in ocular surgery On reading Dr Liu's article “Wound dehiscence after general anesthesia in a child” on your journal [1], they described that total intravenous anesthesia (TIVA) may prevent the postoperative nausea and vomiting (PONV)–induced increase intraocular pressure and wound dehesience in ocular surgery. However, we would like to share our experience of a case with excess nasopharyngeal secretions under TIVA resulting in contamination of surgical field in ocular surgery (Fig. 1).
Intravenous Sedation Without Intubation
and the Risk of Anesthesia Complications for Obese and Non-Obese Women Undergoing Surgical Abortion: A Retrospective Cohort Study.: BACKGROUND: The primary objective of this study was to assess the risk of perioperative anesthesia-related complications in a cohort of obese and non-obese women undergoing outpatient surgical abortion under IV sedation without tracheal intubation. METHODS: We performed a retrospective cohort study of all surgical abortions through 22 6/7 weeks' gestation at an outpatient clinic from 2012 to 2013. Women receiving IV sedation were included. Obesity stat...περισσότερα »
Cardiopulmonary exercise testing in a patient with a permanent tracheostomy
Cardiopulmonary exercise testing in a patient with a permanent tracheostomy: The benefits of cardiopulmonary exercise testing have been well established. Certain patient groups present challenges for conducting such a test. We were presented with a patient with a permanent tracheostomy at the preoperative assessment clinic. We describe our technique in overcoming the problem of connecting him to the testing machine, as this is normally done with the aid of a tight-fitting face mask. We used a cuffed tracheostomy tube together with some widely available tubing from theaters to connec...περισσότερα »
Comparing 3 ventilation modalities by measuring several respiratory parameters using the ProSeal laryngeal mask airway in children
Comparing 3 ventilation modalities by measuring several respiratory parameters using the ProSeal laryngeal mask airway in children: [image: gr1.sml] To determine quantitative differences in several routinely measured ventilation parameters using a standardized anesthetic technique and 3 different ventilation modalities in pediatric patients with a ProSeal laryngeal mask airway (PLMA). Highlights - •We investigated ventilation strategies using the ProSeal LMA (PLMA) in children. - •Quantitative differences in Etco2, tidal volume, and respiratory rate were measure... περισσότερα »
Unexpectedly high incidence of hypothermia before induction of anesthesia in elective surgical patients
Unexpectedly high incidence of hypothermia before induction of anesthesia in elective surgical patients: Perioperative hypothermia is a frequently observed phenomenon of general anesthesia and is associated with adverse patient outcome. Recently, a significant influence of core temperature before induction of anesthesia has been reported. However, there are still little existing data on core temperature before induction of anesthesia and no data regarding potential risk factors for developing preoperative hypothermia. The purpose of this investigation was to estimate the incidence o... περισσότερα »
Inappropriately low bispectral index of the elderly during emergence from sevoflurane anesthesia
Inappropriately low bispectral index of the elderly during emergence from sevoflurane anesthesia: [image: article_notepad.gif] Neuromuscular activity has been previously reported to influence bispectral index (BIS) estimations in both awake volunteers [1] and sedated patients [2,3]. The applicability of BIS monitoring for assessing the depth of anesthesia in elderly individuals is also problematic because electroencephalogram (EEG) in the elderly is known to be electrophysiologically different from those in younger individuals [4,5]. We have described here a case of inappropriatel... περισσότερα »
Advanced Uses of Pulse Oximetry
for Monitoring Mechanically Ventilated Patients.: Pulse oximetry is an undisputable standard of care in clinical monitoring. It combines a spectrometer to detect hypoxemia with a plethysmograph for the diagnosis, monitoring, and follow-up of cardiovascular diseases. These pulse oximetry capabilities are extremely useful for assessing the respiratory and circulatory status and for monitoring of mechanically ventilated patients. On the one hand, the key spectrography-derived function of pulse oximetry is to evaluate a patient's gas exchange that results from a particular ventilatory ... περισσότερα »
Olfaction in Chronic Rhinosinusitis
Olfaction in Chronic Rhinosinusitis: AbstractOlfactory dysfunction is a frequent complaint in chronic rhinosinusitis patients and has a significant impact on quality of life. Therefore, it is essential that clinicians are aware of the importance of olfactory dysfunction in chronic rhinosinusitis (CRS) patients and know how to deal with it. Notably, the evaluation of olfactory function (i.e., using psychophysical testing) and imagery of olfactory bulb play an important role in the evaluation of patients and give essential information about the “baseline” olfactory function. Because ... περισσότερα »
International Guidelines for Hereditary Angioedema
Review of Select Practice Parameters, Evidence-Based Treatment Algorithms, and International Guidelines for Hereditary Angioedema: AbstractHereditary angioedema (HAE) is a rare bradykinin-mediated disease that is characterized by recurrent attacks of subcutaneous or submucosal edema, which can be life threatening. HAE affects all ethnic groups equally and does not differentiate between age, sex, or race. However, the availability of therapies varies amongst countries resulting in a lack of uniformity of care. Not only is there a disparity of medication availability, but since HAE i... περισσότερα »
A pre-eclampsia-associated Epstein-Barr virus antibody
cross-reacts with placental GPR50 via Clinical Immunology Publication date: Available online May 2016 *Source:*Clinical Immunology Author(s): Serra E. Elliott, Nicholas F. Parchim, Rodney E. Kellems, Yang Xia, Alex R. Soffici, Patrick S. Daugherty To characterize antibody specificities associated with pre-eclampsia (PE), bacterial displayed peptide library screening and evolution was applied to identify peptide epitopes recognized by plasma antibodies present in women with PE near the time of delivery. Pre-eclamptic women exhibited elevated IgG1 titers towards a peptide epitope KRPSCI...περισσότερα »
Basophil heterogeneity
New insights into basophil heterogeneity: AbstractBasophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.
Food Allergy Thresholds
Global Perceptions of Food Allergy Thresholds in 16 Countries: Abstract Background Food allergy is a growing global health issue that affects daily life and food purchasing habits. Quality data on the global consumer perspective of food allergy is limited, particularly about thresholds and food labeling risk. Many individuals with food allergy are counseled that small amounts of allergen can potentially cause life-threatening reactions, and to avoid foods with Precautionary Advisory Labeling (PAL). The purpose of this study was to understand attitudes of consumers about food allergy... περισσότερα »
SCORAD is a clinical tool used to assess the extent and severity of eczema (SCORing Atopic Dermatitis)
*Source : http://www.dermnetnz.org/dermatitis/scorad.html* Area *To determine extent, the sites affected by eczema are shaded on a drawing of a body. The rule of 9 is used to calculate the affected area (A) as a percentage of the whole body.* - *Head and neck 9%* - *Upper limbs 9% each* - *Lower limbs 18% each* - *Anterior trunk 18%* - *Back 18%* - *1% for genitals.* *The score for each area is added up. The total area is 'A', which has a possible maximum of 100%.* Intensity *A representative area of eczema is selected. In this area, the intensity of each of the fo... περισσότερα »
Severity Scoring of Atopic Dermatitis : Eosinophil Cationic Proteinhistamine,and Mast Cell Tryptase...Eosinophil cationic protein (ECP), a potent cytotoxic protein of eosinophils, appears to be involved in the pathogenesis of atopic dermatitis as indicated by elevated serum levels
*Download PDF : **http://goo.gl/NRabQv* *The combined determination of serum ECP levels and evaluation of the SCORAD index in atopic dermatitis is not superior to assessment of disease severity by the SCORAD index alone. Owing to the absence of a signi®cant correlation between DSCORAD and DECP in our population we conclude that evaluation of serum ECP levels on admission and at discharge may not be a valid tool for routine quality assurance in unselected patients with atopic dermatitis.* *CLINICAL REPORT Comparison of Severity Scoring of Atopic Dermatitis Values and Serum Levels of...περισσότερα »
CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal B16 melanoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 33 δευτερόλεπτα
Publication date: 1 August 2016 Source:Cancer Letters, Volume 378, Issue 1 Author(s): Kazuhiko Matsuo, Tatsuki Itoh, Atsushi Koyama, Reira Imamura, Shiori Kawai, Keiji Nishiwaki, Naoki Oiso, Akira Kawada, Osamu Yoshie, Takashi Nakayama CCR4 is a major chemokine receptor expressed by Treg cells and Th17 cells. While Treg cells are known to suppress antitumor immunity, Th17 […]
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 33 δευτερόλεπτα
Publication date: 1 August 2016 Source:Cancer Letters, Volume 378, Issue 1 Author(s): Soichiro Sasaki, Tomohisa Baba, Tatsunori Nishimura, Yoshihiro Hayakawa, Shin-ichi Hashimoto, Noriko Gotoh, Naofumi Mukaida From a murine breast cancer cell line, 4T1, we established a subclone, 4T1.3, which consistently metastasizes to bone upon its injection into the mammary fat pad. 4T1.3 clone exhibited […]
Altered Function of the DnaJ Family Co-Chaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 39 δευτερόλεπτα
The highly conserved co-chaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation and degradation. In studies of *C. elegans* locomotion mutants, we identified a gain-of-function (gf) mutation in dnj-17 closely linked to the widely used *e156* null allele of *C. elegans* GAD (glutamic acid decarboxylase) *unc-25. dnj-17* encodes a DnaJ protein orthologous to human DNAJA5. In C. elegans DNJ-17 is a cytosolic protein and is broadly expressed in many tissues. *dnj-17(gf)... περισσότερα »
CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal B16 melanoma
Publication date: 1 August 2016 Source:Cancer Letters, Volume 378, Issue 1 Author(s): Kazuhiko Matsuo, Tatsuki Itoh, Atsushi Koyama, Reira Imamura, Shiori Kawai, Keiji Nishiwaki, Naoki Oiso, Akira Kawada, Osamu Yoshie, Takashi Nakayama CCR4 is a major chemokine receptor expressed by Treg cells and Th17 cells. While Treg cells are known to suppress antitumor immunity, Th17… Continue reading CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal B16 melanoma
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis
Publication date: 1 August 2016 Source:Cancer Letters, Volume 378, Issue 1 Author(s): Soichiro Sasaki, Tomohisa Baba, Tatsunori Nishimura, Yoshihiro Hayakawa, Shin-ichi Hashimoto, Noriko Gotoh, Naofumi Mukaida From a murine breast cancer cell line, 4T1, we established a subclone, 4T1.3, which consistently metastasizes to bone upon its injection into the mammary fat pad. 4T1.3 clone exhibited… Continue reading Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis
Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis
Publication date: 1 August 2016 Source:Cancer Letters, Volume 378, Issue 1 Author(s): Caixia Wang, Heyu Chen, Mingchao Zhang, Jie Zhang, Xunbin Wei, Weihai Ying NADH shuttles, including malate-aspartate shuttle (MAS) and glycerol-3-phosphate shuttle, can shuttle the reducing equivalents of cytosolic NADH into mitochondria. It is widely accepted that the major function of NADH shuttles is… Continue reading Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis
Harmonization of Renal Function Assessment Is Needed Throughout the Whole Process of Anticancer Drug Development CORRESPONDENCE
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Minimal Treatment of Low-Risk, Pediatric Lymphocyte-Predominant Hodgkin Lymphoma: A Report From the Children’s Oncology Group Pediatric Oncology
Purpose Children’s Oncology Group study AHOD03P1 was designed to determine whether excellent outcomes can be maintained for patients with low-risk, pediatric lymphocyte-predominant Hodgkin lymphoma (LPHL) with a strategy of resection alone or minimal chemotherapy. Patients and Methods Patients with stage IA LPHL in a single node that was completely resected were observed without further therapy;… Continue reading Minimal Treatment of Low-Risk, Pediatric Lymphocyte-Predominant Hodgkin Lymphoma: A Report From the Children’s Oncology Group Pediatric Oncology
Top 50 Most-Cited Journal of Clinical Oncology Articles From 2013 JCO TOP 50
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/200dxEV via IFTTT
Improvements in spinal alignment after high tibial osteotomy in patients with medial compartment knee osteoarthritis
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Yoon Hyuk Kim, Ariunzaya Dorj, Ahreum Han, Kyungsoo Kim, Kyung Wook Nha Since the correlation between spinal and lower extremity alignments is high, high tibial osteotomy (HTO) surgery may also affect spinal alignment, where the spinal alignment parameters are the most important parameters for the evaluation of spinal disorders. In this study, the effect of HTO surgery on spinal alignment during gait was investigated by comparing spinal alignment parameters between patients with knee osteoarthritis (OA) ...περισσότερα »
Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Maryam Hadizadeh, Saidon Bin Amri, Hamidreza Mohafez, Sharifah Roohi Ahmad, Abdul Halim Bin Mokhtar This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty two national athletes with ACL reconstruction and 15 healthy athletes were recruited for the study. Gait data were collected between the weeks 4-5, 8-9, and 12-13 post operation using three-dimensional motion analysis system. ... περισσότερα »
Spatiotemporal, kinematic, force and muscle activation outcomes during gait and functional exercise in water compared to on land: A systematic review
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Sophie Heywood, Jodie McClelland, Paula Geigle, Ann Rahmann, Ross Clark BackgroundExercises replicating functional activities are commonly used in aquatic rehabilitation although it is not clear how the movement characteristics differ between the two environments. A systematic review was completed in order to compare the biomechanics of gait, closed kinetic chain and plyometric exercise when performed in water and on land.MethodsDatabases including MEDLINE, CINAHL, SPORTDiscus, Embase and the Cochrane l... περισσότερα »
Control conditions for footwear insole and orthotic research
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Ryan T. Lewinson, Jay T. Worobets, Darren J. Stefanyshyn Footwear insoles/orthotics alter variables associated with musculoskeletal injury; however, their clinical effectiveness is inconclusive. One explanation for this is the possibility that control conditions may actually produce biomechanical changes that induce clinical responses. The purpose of this study was to compare insole/orthotic control conditions to identify if variables at the ground, ankle and knee that are associated with injury, are alt... περισσότερα »
Accuracy and reliability of the RGB-D camera for measuring walking speed on a treadmill
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): B. Fosty, G. Ben-Sadoun, G. Sacco, A. König, V. Manera, P. Foulon, J. Brisswalter, P.H. Robert, F. Bremond AimRGB-D cameras (Red Green Blue+Depth) are widely employed in exergames designed to physically stimulate elderly people. Nevertheless, the intensity of the physical activity reached with the existing solutions is rarely sufficient to obtain a real impact on the physical fitness and thus on the health status of this population. In this context, a Point Cloud Based System (PCBS) has been developed to... περισσότερα »
Improvements in spinal alignment after high tibial osteotomy in patients with medial compartment knee osteoarthritis
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Yoon Hyuk Kim, Ariunzaya Dorj, Ahreum Han, Kyungsoo Kim, Kyung Wook Nha Since the correlation between spinal and lower extremity alignments is high, high tibial osteotomy (HTO) surgery may also affect spinal alignment, where the spinal alignment parameters are the most important parameters for the evaluation of spinal disorders. In this study, the effect of HTO surgery on spinal alignment during gait was investigated by comparing spinal alignment parameters between patients with knee osteoarthritis (OA) ...περισσότερα »
Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Maryam Hadizadeh, Saidon Bin Amri, Hamidreza Mohafez, Sharifah Roohi Ahmad, Abdul Halim Bin Mokhtar This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty two national athletes with ACL reconstruction and 15 healthy athletes were recruited for the study. Gait data were collected between the weeks 4-5, 8-9, and 12-13 post operation using three-dimensional motion analysis system. ... περισσότερα »
Spatiotemporal, kinematic, force and muscle activation outcomes during gait and functional exercise in water compared to on land: A systematic review
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Sophie Heywood, Jodie McClelland, Paula Geigle, Ann Rahmann, Ross Clark BackgroundExercises replicating functional activities are commonly used in aquatic rehabilitation although it is not clear how the movement characteristics differ between the two environments. A systematic review was completed in order to compare the biomechanics of gait, closed kinetic chain and plyometric exercise when performed in water and on land.MethodsDatabases including MEDLINE, CINAHL, SPORTDiscus, Embase and the Cochrane l... περισσότερα »
Control conditions for footwear insole and orthotic research
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Ryan T. Lewinson, Jay T. Worobets, Darren J. Stefanyshyn Footwear insoles/orthotics alter variables associated with musculoskeletal injury; however, their clinical effectiveness is inconclusive. One explanation for this is the possibility that control conditions may actually produce biomechanical changes that induce clinical responses. The purpose of this study was to compare insole/orthotic control conditions to identify if variables at the ground, ankle and knee that are associated with injury, are alt... περισσότερα »
Accuracy and reliability of the RGB-D camera for measuring walking speed on a treadmill
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): B. Fosty, G. Ben-Sadoun, G. Sacco, A. König, V. Manera, P. Foulon, J. Brisswalter, P.H. Robert, F. Bremond AimRGB-D cameras (Red Green Blue+Depth) are widely employed in exergames designed to physically stimulate elderly people. Nevertheless, the intensity of the physical activity reached with the existing solutions is rarely sufficient to obtain a real impact on the physical fitness and thus on the health status of this population. In this context, a Point Cloud Based System (PCBS) has been developed to... περισσότερα »
Improvements in spinal alignment after high tibial osteotomy in patients with medial compartment knee osteoarthritis
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Yoon Hyuk Kim, Ariunzaya Dorj, Ahreum Han, Kyungsoo Kim, Kyung Wook Nha Since the correlation between spinal and lower extremity alignments is high, high tibial osteotomy (HTO) surgery may also affect spinal alignment, where the spinal alignment parameters are the most important parameters for the evaluation of spinal disorders. In this study, the effect of HTO surgery on spinal alignment during gait was investigated by comparing spinal alignment parameters between patients with knee osteoarthritis (OA) ...περισσότερα »
Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Maryam Hadizadeh, Saidon Bin Amri, Hamidreza Mohafez, Sharifah Roohi Ahmad, Abdul Halim Bin Mokhtar This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty two national athletes with ACL reconstruction and 15 healthy athletes were recruited for the study. Gait data were collected between the weeks 4-5, 8-9, and 12-13 post operation using three-dimensional motion analysis system. ... περισσότερα »
Spatiotemporal, kinematic, force and muscle activation outcomes during gait and functional exercise in water compared to on land: A systematic review
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Sophie Heywood, Jodie McClelland, Paula Geigle, Ann Rahmann, Ross Clark BackgroundExercises replicating functional activities are commonly used in aquatic rehabilitation although it is not clear how the movement characteristics differ between the two environments. A systematic review was completed in order to compare the biomechanics of gait, closed kinetic chain and plyometric exercise when performed in water and on land.MethodsDatabases including MEDLINE, CINAHL, SPORTDiscus, Embase and the Cochrane l... περισσότερα »
Control conditions for footwear insole and orthotic research
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Ryan T. Lewinson, Jay T. Worobets, Darren J. Stefanyshyn Footwear insoles/orthotics alter variables associated with musculoskeletal injury; however, their clinical effectiveness is inconclusive. One explanation for this is the possibility that control conditions may actually produce biomechanical changes that induce clinical responses. The purpose of this study was to compare insole/orthotic control conditions to identify if variables at the ground, ankle and knee that are associated with injury, are alt... περισσότερα »
Accuracy and reliability of the RGB-D camera for measuring walking speed on a treadmill
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): B. Fosty, G. Ben-Sadoun, G. Sacco, A. König, V. Manera, P. Foulon, J. Brisswalter, P.H. Robert, F. Bremond AimRGB-D cameras (Red Green Blue+Depth) are widely employed in exergames designed to physically stimulate elderly people. Nevertheless, the intensity of the physical activity reached with the existing solutions is rarely sufficient to obtain a real impact on the physical fitness and thus on the health status of this population. In this context, a Point Cloud Based System (PCBS) has been developed to... περισσότερα »
A computational model to predict severity of atopic eczema
from 30 serum proteins via Allergy and Clinical Immunology Publication date: Available online 13 May 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Linda Krause, Vagkan Mourantchanian, Knut Brockow, Fabian J. Theis, Carsten B. Schmidt-Weber, Bettina Knapp, Nikola S. Mueller, Stefanie Eyerich TeaserPrediction of atopic eczema severity by use of serum proteins is a helpful tool for monitoring objective therapeutic response. Here, we applied advanced computational models to identify the optimal combination out of 30 serum proteins for SCORAD prediction in a large pa...περισσότερα »
Mast cell protease content can shape its releasate profile. Mast cell chymase-mediated downregulation of factor XIIIA via proteolytic cleavage contributes to reduce clotting in normal conditions and during sepsis.
Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation via Allergy and Clinical Immunology Publication date: Available online 13 May 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Nicholas J. Shubin, Veronika A. Glukhova, Morgan Clauson, Phuong Truong, Magnus Abrink, Gunnar Pejler, Nathan J. White, Gail H. Deutsch, Stephen R. Reeves, Tomas Vaisar, Richard G. James, Adrian M. Piliponsky BackgroundMast cells are significantly involved in IgE-mediated allergic reactions; howe...περισσότερα »
Autosomal dominant hyper-IgE syndrome
Elucidating the effects of disease-causing mutations on STAT3 function in via Allergy and Clinical Immunology Publication date: Available online 13 May 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Simon J. Pelham, Helen Lenthall, Elissa K. Deenick, Stuart G. Tangye TeaserAnalysis of germline mutations in STAT3 that cause AD-HIES revealed biochemical mechanisms of disease-causation. This has implications for developing therapeutics that could modulate the function of STAT3 in the settings of immunodeficiency, autoimmunity and malignancy. AD-HIES, autosomal domina...περισσότερα »
Allergy to Rabbit or Cow’s Milk
Allergenicity and Safety of rhC1INH in Patients with Allergy to Rabbit or Cow’s Milk via Allergy and Clinical Immunology Publication date: Available online May 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): M.T. van den Elzen, H. van Os-Medendorp, H. Röckmann-Helmbach, E. van Hoffen, A.F.M. Lebens, W.A. van Doorn, R.J.B. Klemans, C.A.F.M. Bruijnzeel-Koomen, C.E. Hack, L. Kaufman, A. Relan, A.C. Knulst BackgroundRecombinant human C1 inhibitor (rhC1INH) for on demand treatment of hereditary angioedema, is purified from milk of transgenic rabbits. It contains low amou... περισσότερα »
A rhinitis phenotype associated with increased development of bronchial hyperresponsiveness and asthma
in children via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 13 May 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Eun Lee, Si Hyeon Lee, Ji-Won Kwon, Yeongho Kim, Hyun-Ju Cho, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo Bin Kim, So Yeon Lee, Ho-Jang Kwon, Soo-Jong Hong BackgroundAllergic rhinitis (AR) has a wide range of clinical features and may be accompanied by comorbid allergic diseases.ObjectivesTo identify rhinitis phenotypes in school aged children and to predict the prognos... περισσότερα »
Allergenic food introduction
Parental timing of allergenic food introduction in urban and suburban populations via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 13 May 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Heather Hartman, Caitlin Dodd, Marepalli Rao, Dominick DeBlasio, Christine Labowsky, Sharon D'Souza, Siga Lenkauskas, Eve Roeser, Alison Heffernan, Amal Assa'ad BackgroundRecommendations on timing for introduction of allergenic foods in an infant diet have changed twice during the past decade. How families with different demographic... περισσότερα »
Indoor Allergens and Allergic Respiratory Disease
Indoor Allergens and Allergic Respiratory Disease: Abstract Purpose of reviewThe purpose of this review is to evaluate the most recent findings on indoor allergens and their impact on allergic diseases. Recent findingsIndoor allergens are present inside buildings (home, work environment, school), and given the chronic nature of the exposures, indoor allergies tend to be associated with the development of asthma. The most common indoor allergens are derived from dust mites, cockroaches, mammals (including wild rodents and pets), and fungi. The advent of molecular biology and pro... περισσότερα »
Active pediatric eosinophilic esophagitis
Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis via Allergy and Clinical Immunology Publication date: Available online 16 May 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): David W. Morris, Emily M. Stucke, Lisa J. Martin, J. Pablo Abonia, Vincent A. Mukkada, Philip E. Putnam, Marc E. Rothenberg, Patricia C. Fulkerson [image: A, Median absolute EoP levels in patients with active versus inactive EoE are ...] [image: Gating strategy for EoPs. Live CD45RA− cells were gated for CD34+ events. This ...] [image: Median...περισσότερα »
Specific allergen immunotherapy for the treatment of atopic eczema
a systematic review: Abstract Background Specific allergen immunotherapy (SIT) is an effective allergy treatment, but it is unclear whether SIT is effective for atopic eczema (AE). We undertook a systematic review to assess SIT efficacy and safety for treating AE. Methods We searched databases, ongoing clinical trials registers, and conference proceedings up to July 2015. Randomised-controlled trials (RCTs) of SIT using standardised allergen extracts, compared with placebo/control for treating AE in patients with allergic sensitisation were eligible. Results We identified 12 e... περισσότερα »
Bacterial profile of otitis media with effusion
MALDI-TOF mass spectrometry reveals a highly complex bacterial profile of otitis media with effusion via International Journal of Pediatric Otorhinolaryngology Publication date: July 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 86 Author(s): Zoltán Papp, Halima Elgabsi, László Tóth ObjectivesWith conventional microbiological methods, a significant proportion of middle ear effusion (MEE) proves to be sterile. Accurate molecular biological techniques have been used to identify only pathogenic bacteria. Matrix assisted laser desorption and ionization time-of... περισσότερα »
Post-Traumatic Headache Therapy
in the Athlete: AbstractPost-traumatic headache can occur after any traumatic brain injury, regardless of severity. Headache is consistently the most common symptom following concussion and occurs in over 90 % of athletes with sports-related concussion. Despite this prevalence, the complaint of headache after a possible concussive injury is often dismissed. Even when sports-related concussion is accurately diagnosed, many athletes fall victim to mismanagement of this associated symptom by clinicians who are not well-versed in headache treatment. Furthermore, benign headaches may ... περισσότερα »
The Pathophysiology of Concussion
The Pathophysiology of Concussion: AbstractConcussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what happens in the brain after traumatic brain injury, particularly with milder injuries where no damage can be seen at the structural level on standard neuroimaging. Understanding the chain of events from a cellular level using s... περισσότερα »
Salivary duct carcinoma of parotid gland
Clinicopathological features and treatment outcomes of the rare, salivary duct carcinoma of parotid gland Abstract Background Salivary ductal carcinoma (SDC) of parotid gland is a rare and aggressive entity; accounting for 1–3 % of all malignant salivary gland tumors, 0.2 % of epithelial salivary gland neoplasms, 0.5 % of salivary gland carcinomas, and 1.1 % of parotid gland carcinomas. Here in we aimed to evaluate the clinico-pathological features and treatment outcomes of parotid gland SDC in Saudi population. Methods Among 38 patients with parotid malignancies, who were... περισσότερα »
Effects of Levothyroxine Therapy on Pregnancy Outcomes in Women with Subclinical Hypothyroidism
Effects of Levothyroxine Therapy on Pregnancy Outcomes in Women with Subclinical Hypothyroidism: [image: access_free.gif] Thyroid , Vol. 0, No. 0. Author information Spyridoula Maraka,1,2 Naykky M. Singh Ospina,1,2 Derek T. O'Keeffe,1,3 Rene Rodriguez-Gutierrez,1,2,4Ana E. Espinosa De Ycaza,1 Chung-Il Wi,5 Young J. Juhn,5 Charles C. Coddington III,6 Victor M. Montori,1,2 and Marius N. Stan1 1Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota. 2Knowledge and Evaluation Research Unit (KER-Endo), Mayo Clinic, Rochester, Minnesota. 3Div...περισσότερα »
Adults with single-sided deafness
Determination and classification of the problems experienced by adults with single-sided deafness using ICF classification: An exploratory study using twenty six participants: Abstract 1.Previous studies have shown the application of ICF in classifying hearing problems using open ended questionnaire. 2.The present study leveraged on that concept and used ICF in classifying hearing related problems and their effects on life style in adults with single-sided deafness. 3.We have used “problem and life effects” questionnaire to which patients were asked to list the problems and effects ... περισσότερα »
The epidemiology of head and neck cancer
Trends in the epidemiology of head and neck cancer in London: Abstract Background Head and neck cancers (HNCs) are biologically heterogeneous tumours. The objectives of this study were to describe trends in incidence of HNCs amongst London residents by sex, age, anatomical site, deprivation and ethnicity. Methods Annual age-standardised incidence rates [ASRs] were calculated on HNC registration data, overall and for specific cancer sites, by sex and morphology (1985-2010); and area socio-economic deprivation score (2006-2010). Age-standardised incidence rate-ratios (IRRs) for the ma...περισσότερα »
Outcomes of intensity-modulated radiotherapy as primary treatment for oropharyngeal squamous cell carcinoma
a European single institution analysis: Abstract Objectives To analyze survival and toxicity outcomes in patients treated with primary intensity-modulated radiotherapy (IMRT) for oropharyngeal squamous cell carcinoma (OPSCC) in the era of routine human papilloma virus (HPV) testing. Design Single institution case series. Setting Tertiary Head and Neck Cancer Unit Participants 186 patients who received IMRT (+/- chemotherapy) for radical primary treatment of OPSCC between March 2010 and December 2013. HPV status was available for 88% of cases. Median radiation dose was 65Gy in 30 ...περισσότερα »
Geometrical parameter combinations that correlate with early interaural cross-correlation coefficients in a performance hall
Geometrical parameter combinations that correlate with early interaural cross-correlation coefficients in a performance hall: [image: cm_sbs_024_plain.png] The previous binaural data of the authors measured inside two multi-purpose performance halls are re-analyzed using regression in this study. It is done in an attempt to establish a framework that can improve the prediction of early interaural cross-correlation coefficients (IACCs), but with as little measurement effort and parameters as possible. The results show that regression models consist of linear combinations of polynomi... περισσότερα »
Effects of noise, reverberation and foreign accent on native and non-native listeners' performance of English speech comprehension
Effects of noise, reverberation and foreign accent on native and non-native listeners' performance of English speech comprehension: [image: cm_sbs_024_plain.png] A large number of non-native English speakers may be found in American classrooms, both as listeners and talkers. Little is known about how this population comprehends speech in realistic adverse acoustical conditions. A study was conducted to investigate the effects of background noise level (BNL), reverberation time (RT), and talker foreign accent on native and non-native listeners' speech comprehension, while controllin... περισσότερα »
RGB-D cameras (Red Green Blue+Depth) for measuring walking speed on a treadmill
Accuracy and reliability of the RGB-D camera via Gait & Posture Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): B. Fosty, G. Ben-Sadoun, G. Sacco, A. König, V. Manera, P. Foulon, J. Brisswalter, P.H. Robert, F. Bremond AimRGB-D cameras (Red Green Blue+Depth) are widely employed in exergames designed to physically stimulate elderly people. Nevertheless, the intensity of the physical activity reached with the existing solutions is rarely sufficient to obtain a real impact on the physical fitness and thus on the health status of this population. In this c... περισσότερα »
Malignant Melanoma of the Nail Apparatus: A Fluorescence In Situ Hybridization Analysis of 7 Cases
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Background*. Malignant melanoma of the nail apparatus is exceedingly rare. Increasingly, genetic studies have been employed to aid in distinguishing between malignant melanoma and benign melanocytic nevi. *Methods*. Archived nail apparatus melanomas were analyzed by fluorescence in situ hybridization (FISH) using probes targeting the genes at 6p25 (RREB1), 11q13 (CCND1), 8q24.1 (MYC), 6q23 (MYB), 9p21 (CDKN2A) and the centromeres of chromosomes 8 (D8Z2) and 6 (D6Z1). The results were correlated with clinical and demographic information. *Results*. Mean patient age was 57.8 years ... περισσότερα »
Metagenomic Insights into Transferable Antibiotic Resistance in Oral Bacteria
Antibiotic resistance is considered one of the greatest threats to global public health. Resistance is often conferred by the presence of antibiotic resistance genes (ARGs), which are readily found in the oral microbiome. In-depth genetic analyses of the oral microbiome through metagenomic techniques reveal a broad distribution of ARGs (including novel ARGs) in individuals not recently exposed to antibiotics, including humans in isolated indigenous populations. This has resulted in a paradigm shift from focusing on the carriage of antibiotic resistance in pathogenic bacteria to a ... περισσότερα »
Randomized Phase II Study of Trabectedin and Doxorubicin Compared With Doxorubicin Alone as First-Line Treatment in Patients With Advanced Soft Tissue Sarcomas: A Spanish Group for Research on Sarcoma Study Sarcomas
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose Doxorubicin and trabectedin are considered active drugs in soft tissue sarcoma (STS). The combination of both drugs was hypothesized to be advantageous and safe on the basis of preclinical evidence and a previous phase I trial, respectively. The aim of this study was to compare the clinical outcome of trabectedin plus doxorubicin with doxorubicin […]
Obvious Pitfall in the Estimation of Renal Dysfunction CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1stIY08 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reply to C.S. Hourigan et al CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/200dgld via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
When the Minimal Becomes Measurable CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1stJ2gf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer Clinical Trials
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose Older adults are at increased risk for chemotherapy toxicity, and standard oncology assessment measures cannot identify those at risk. A predictive model for chemotherapy toxicity was developed (N = 500) that consisted of geriatric assessment questions and other clinical variables. This study aims to externally validate this model in an independent cohort (N = […]
Antimetastatic Properties of Low Molecular Weight Heparin CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1stJ1sX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Still Refining Adjuvant Endocrine Therapy in Premenopausal Women: Not Too Much, Not Too Little EDITORIAL
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/200ducd via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Acculturation levels and personalizing orthognathic surgery for the Asian American patient
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 16 May 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): A.A. Sy, W.S. Kim, J. Chen, Y. Shen, C. Tao, J.S. Lee This study was performed to investigate whether the level of acculturation among Asians living in the USA plays a significant role in their opinion of facial profiles. One […]
Norovirus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Norovirus: A group of viruses that are a common cause of food poisoning and acute gastroenteritis («stomach flu«) that can strike quickly with force and make a person feel very sick but which typically resolves within 2-3 days. The characteristic symptoms are nausea, vomiting, diarrhea, and abdominal cramping. The diarrhea is not bloody. Fever, if […]
New drugs for medullary thyroid cancer: new promises?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Medullary thyroid cancer (MTC) is a rare tumor arising from the calcitonin-producing parafollicular C cells of the thyroid gland, occurring either sporadically, or alternatively in a hereditary form based on germline RET mutations in approximately one third of cases. Historically, patients with advanced, metastasized MTC have had a poor prognosis, partly due to limited response […]
Acculturation levels and personalizing orthognathic surgery for the Asian American patient
Publication date: Available online 16 May 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): A.A. Sy, W.S. Kim, J. Chen, Y. Shen, C. Tao, J.S. Lee This study was performed to investigate whether the level of acculturation among Asians living in the USA plays a significant role in their opinion of facial profiles. One hundred and ninety-eight Asian American subjects were asked to complete a pre-validated survey to measure their level of acculturation and to evaluate four sets of pictures that displayed a class II male, class II female, class III male, and... περισσότερα »
Intracranial Pressure Assessment in Traumatic Head Injury with Hemorrhage Via Optic Nerve Sheath Diameter
Journal of Neurotrauma , Vol. 0, No. 0. from Neurology via xlomafota13 on Inoreader http://ift.tt/1VZlo7e via IFTTT
Specific allergen immunotherapy for the treatment of atopic eczema: a systematic review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Specific allergen immunotherapy (SIT) is an effective allergy treatment, but it is unclear whether SIT is effective for atopic eczema (AE). We undertook a systematic review to assess SIT efficacy and safety for treating AE. Methods We searched databases, ongoing clinical trials registers, and conference proceedings up to July 2015. Randomised-controlled trials (RCTs) […]
Penis operation highlights past, future of organ transplants – WAND
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
WAND Penis operation highlights past, future of organ transplants WAND CHICAGO (AP) – Add one remarkable case to the 30,000-plus organ transplants expected to be performed nationwide this year: A cancer patient who received a donor penis. Worldwide, there have been faces, tongues, hands, legs, uteruses – and now the … and more » from […]
Employment in French young adult survivors of childhood leukemia: an LEA study (for Leucemies de l’Enfant et de l’Adolescent—childhood and adolescent leukemia)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Purpose Our principal aim was to assess the occupational outcomes of French survivors of childhood leukemia, compared to national population. The secondary objective was to identify determinants linked with employment stability after childhood leukemia. Methods All survivors aged 15 and over enrolled in the French LEA Cohort (Childhood and Adolescent Leukemia) were included. Occupational […]
The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Chronic Myeloid Leukemia was always referred as a unique cancer due to the apparent independence from tumor suppressors’ deletions/mutations in the early stages of the disease. However, it is now well document… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/27udRBk via IFTTT
MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
MicroRNA-663a expression is downregulated in several tumors. However, its functions and mechanisms in human non-small cell lung (NSCLC) cancer remain obscure. The present study aimed to identify the expression… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24Wf7em via IFTTT
Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Activation of signal transducer and activator of transcription 3 (STAT3) is well known to play a major role in the cell growth, survival, proliferation, metastasis, and angiogenesis of various cancer cells. Most of the citrus species offer large quantities of phytochemicals that have beneficial effects attributed to their chemical components. Our study was carried out […]
PIM inhibitors selectively kill hypoxic tumor cells
Intratumoral hypoxia is a significant obstacle to the successful treatment of solid tumors, and it is highly correlated with metastasis, therapeutic resistance, and disease recurrence in cancer patients. As a result, there is an urgent need to develop effective therapies that target hypoxic cells within the tumor microenvironment. The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a pro-survival pathway that is upregulated in response to hypoxia, in a HIF-1-independent manner. We demonstrate that pharmacological or genetic inhibition of PIM kinases is ... περισσότερα »
mTORC1/2 in ovarian cancer platinum resistance
There is considerable interest in the clinical development of inhibitors of mTOR complexes mTORC1 and 2. Because mTORC1 and its downstream mRNA translation effectors may protect against genotoxic DNA damage, we investigated the inhibition of mTORC1 and mTORC1/2 in the ability to reverse platinum resistance in tissue culture and in animal tumor models of serous ovarian cancer. Cell survival, tumor growth, PI3K-AKT-mTOR pathway signaling, DNA damage and repair response (DDR) gene expression and translational control were all investigated. We show that platinum resistant OVCAR-3 ovar... περισσότερα »
Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model
Activation of signal transducer and activator of transcription 3 (STAT3) is well known to play a major role in the cell growth, survival, proliferation, metastasis, and angiogenesis of various cancer cells. Most of the citrus species offer large quantities of phytochemicals that have beneficial effects attributed to their chemical components. Our study was carried out to evaluate the anticancer effects of the pericarp of Iyokan (*Citrus iyo* Hort. ex Tanaka), locally known as yeagam in Korea, through modulation of the STAT3 signaling pathway in both tumor cells and a nude mice mode... περισσότερα »
Biomarkers for outcome of pembrolizumab-treated patients
Purpose: Biomarkers for outcome after immune-checkpoint blockade are strongly needed as these may influence individual treatment selection or sequence. We aimed to identify baseline factors associated with overall survival (OS) following pembrolizumab treatment in melanoma patients. Experimental design: Serum lactate dehydrogenase (LDH), routine blood count parameters, and clinical characteristics were investigated in 616 patients. Endpoints were OS and best overall response following pembrolizumab. Kaplan-Meier analysis and Cox regression were applied for survival analysis. Resul...περισσότερα »
Full-field OCT in ovarian tissue
Purpose: Autotransplantation of ovarian tissue can be used to restore fertility in cancer patients following gonadotoxic treatment. Whether this procedure is safe remains unclear, as current tumor detection methods render the ovarian tissue unsuitable for transplantation. Full-field optical coherence tomography (FF-OCT) is an imaging modality that rapidly produces high-resolution histology-like images without the need to fix, freeze, or stain the tissue. In this proof-of-concept study, we investigated whether FF-OCT can be used to detect metastases in ovarian tissue, thereby incre... περισσότερα »
Molecular predictors of response to fulvetsrant
Purpose: Fulvestrant is an estrogen receptor (ER) antagonist and an approved treatment for metastatic estrogen receptor positive (ER+) breast cancer. With the exception of ER levels, there are no established predictive biomarkers of response to single agent fulvestrant. We attempted to identify a gene signature of response to fulvestrant in advanced breast cancer. Experimental Design: Primary tumor samples from 134 patients enrolled in the phase III CONFIRM study of patients with metastatic ER+ breast cancer comparing treatment with either 250mg or 500mg fulvestrant were collected... περισσότερα »
Prediction of pathological response for LARC using MRI
Purpose:To evaluate multi-parametric MRI features in predicting pathological response after preoperative chemo-radiation therapy (CRT) for locally advanced rectal cancer (LARC). Experimental Design: Forty-eight consecutive patients (01/2012-11/2014) receiving neoadjuvant CRT were enrolled. All underwent anatomical T1/T2, Diffusion-Weighted-MRI(DWI) and Dynamic-Contrast-Enhanced(DCE)-MRI before CRT. A total of 103 imaging features, analyzed using both volume-averaged and voxelized methods, were extracted for each patient. Univariate analyses were performed to evaluate the capabilit...περισσότερα »
MET, FOXM1 and DNA damage-induced senescence
Purpose: Deregulated signaling via the MET receptor tyrosine kinase is abundant in gastric tumors, with up to 80% of cases displaying aberrant MET expression. A growing body of evidence suggests MET as a potential target for tumor radiosensitization. Experimental Design: Cellular proliferation and DNA damage-induced senescence were studied in a panel of MET-overexpressing human gastric cancer cell lines as well as in xenograft models following MET inhibition and/or ionizing radiation. Pathways activation and protein expression were assessed by immunoblotting and immunohistochemist... περισσότερα »
Intra-tumor heterogeneity in GEP test risk stratification
Purpose: To examine the effect of intra-tumor heterogeneity (ITH) on detection of genes within gene expression panels (GEPs), and the subsequent ability to predict prognostic risk. Experimental Design: Multiplexed barcoded RNA analysis was used to measure the expression of 141 genes from five GEPs (Oncotype Dx, MammaPrint, PAM50, EndoPredict, and Breast Cancer Index) in breast cancer tissue sections and tumor-rich cores from 71 estrogen receptor (ER) positive node-negative tumors, on which clinical Oncotype Dx testing was previously performed. If the tumor had foci of high Ki67 (n...περισσότερα »
ACRIN6684: MRI and FMISO PET in newly diagnosed GBM
Purpose: Structural and functional alterations in tumor vasculature are thought to contribute to tumor hypoxia which is a primary driver of malignancy through its negative impact on the efficacy of radiation, immune surveillance, apoptosis, genomic stability, and accelerated angiogenesis. We performed a prospective, multicenter study to test the hypothesis that abnormal tumor vasculature and hypoxia, as measured with MRI and PET, will negatively impact survival in patients with newly diagnosed glioblastoma (GBM). Experimental Design: Prior to start of chemoradiation, GBM patients ... περισσότερα »
Use of Liquid Biopsies in Clinical Oncology
Purpose: There is growing interest in using circulating tumor DNA (ctDNA) testing in patients with cancer. Experimental Design: 168 patients with diverse cancers were analyzed. Patients had digital next-generation sequencing (54 cancer-related gene panel including amplifications in ERBB2, EGFR, and MET) performed on their plasma. Type of genomic alterations, potential actionability, concordance with tissue testing, and patient outcome were examined. Results: Fifty-eight percent of patients (98/168) had {greater than or equal to}1 ctDNA alteration(s). Of the 98 patients with altera... περισσότερα »
Cross Talk between Cancer Cells and Neighboring Cells May Contribute to Tumor Growth
Pancreatic tumor cells and neighboring normal cells engage in a two-way molecular conversation that helps drive malignant behavior in the cancer cells, according to new study results. Working in cell lines from mice, researchers showed that pancreatic cancer cells that have cancer-causing mutations in the *KRAS* gene can coerce nearby healthy cells to release growth signals. These signals then activate a chain of events in the tumor cells that enhance their ability to survive and multiply. from Cancer via ola Kala on Inoreader http://ift.tt/1Tjz1fe via IFTTT
Specific allergen immunotherapy for the treatment of atopic eczema: a systematic review
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Specific allergen immunotherapy (SIT) is an effective allergy treatment, but it is unclear whether SIT is effective for atopic eczema (AE). We undertook a systematic review to assess SIT efficacy and safety for treating AE. Methods We searched databases, ongoing clinical trials registers, and conference proceedings up to July 2015. Randomised-controlled trials (RCTs) […]
Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation
Volume 17, Issue 5, May 2016, pages 558-565<br>10.1080/15384047.2016.1177675<br>Ning Wu from Cancer via ola Kala on Inoreader http://ift.tt/1TTWwHW via IFTTT
The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer
Volume 17, Issue 5, May 2016, pages 566-576<br>10.1080/15384047.2016.1177676<br>Xin Jin from Cancer via ola Kala on Inoreader http://ift.tt/1OyEEpI via IFTTT
Abrus agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death
Abstract *Abrus* agglutinin (AGG), a type II ribosome-inactivating protein has been found to induce mitochondrial apoptosis. In the present study, we documented that AGG-mediated Akt dephosphorylation led to ER stress resulting the induction of autophagy-dependent cell death through the canonical pathway in cervical cancer cells. Inhibition of autophagic death with 3-methyladenosine (3-MA) and siRNA of Beclin-1 and ATG5 increased AGG-induced apoptosis. Further, inhibiting apoptosis by Z-DEVD-FMK and N-acetyl cysteine (NAC) increased autophagic cell death after AGG treatment, sugge... περισσότερα »
KRAS and TP53 mutations in bronchoscopy samples from former lung cancer patients
Abstract Mutations in the KRAS and TP53 genes have been found frequently in lung tumors and specimens from individuals at high risk for lung cancer and have been suggested as predictive markers for lung cancer. In order to assess the prognostic value of these 2 genes' mutations in lung cancer recurrence, we analyzed mutations in codon 12 of the KRAS gene and in hotspot codons of the TP53 gene in 176 bronchial biopsies obtained from 77 former lung cancer patients. Forty-seven patients (61.0%) showed mutations, including 35/77 (45.5%) in the KRAS gene and 25/77 (32.5%) in the TP53 ge...περισσότερα »
Decreased LRIG1 in Human Ovarian Cancer Cell SKOV3 Upregulates MRP-1 and Contributes to the Chemoresistance of VP16
Cancer Biotherapy & Radiopharmaceuticals May 2016, Vol. 31, No. 4: 125-132. from Cancer via ola Kala on Inoreader http://ift.tt/1TFeRJ0 via IFTTT
Effects of Levothyroxine Therapy on Pregnancy Outcomes in Women with Subclinical Hypothyroidism
[image: access_free.gif] Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/1TFEeKH via IFTTT
Outcomes of intensity-modulated radiotherapy as primary treatment for oropharyngeal squamous cell carcinoma – a European single institution analysis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: cover.gif?v=1&s=720aa04a77c44b0d42aede1e] Abstract Objectives To analyze survival and toxicity outcomes in patients treated with primary intensity-modulated radiotherapy (IMRT) for oropharyngeal squamous cell carcinoma (OPSCC) in the era of routine human papilloma virus (HPV) testing. Design Single institution case series. Setting Tertiary Head and Neck Cancer Unit Participants 186 patients who received IMRT (+/- chemotherapy) for radical primary treatment of OPSCC between March 2010 and December 2013. HPV status was available for 88% of cases. Median radiation dose w...περισσότερα »
Altered Function of the DnaJ Family Co-Chaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model
The highly conserved co-chaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation and degradation. In studies of *C. elegans* locomotion mutants, we identified a gain-of-function (gf) mutation in dnj-17 closely linked to the widely used *e156* null allele of *C. elegans* GAD (glutamic acid decarboxylase) *unc-25. dnj-17* encodes a DnaJ protein orthologous to human DNAJA5. In C. elegans DNJ-17 is a cytosolic protein and is broadly expressed in many tissues. *dnj-17(gf)... περισσότερα »
Exhaustive Genome-Wide Search for SNP-SNP Interactions Across Ten Human Diseases
Background: The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets. We aimed to use data from the Resource for Genetic Epidemiology Research on Adult Health and Aging (GERA) study to search for SNP-SNP interactions associated with ten common diseases. Methods: FastEpistasis and BOOST were used to evaluate all pairwise interactions among approximately N=300,000 single nucleotide polymorphisms (SNPs) wit... περισσότερα »
Effects of Levothyroxine Therapy on Pregnancy Outcomes in Women with Subclinical Hypothyroidism
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TFFAFc via IFTTT
MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD
MicroRNA-663a expression is downregulated in several tumors. However, its functions and mechanisms in human non-small cell lung (NSCLC) cancer remain obscure. The present study aimed to identify the expression… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/24Wf7em via IFTTT
Clinicopathological features and treatment outcomes of the rare, salivary duct carcinoma of parotid gland
Salivary ductal carcinoma (SDC) of parotid gland is a rare and aggressive entity; accounting for 1–3 % of all malignant salivary gland tumors, 0.2 % of epithelial salivary gland neoplasms, 0.5 % of salivary gl… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XheCcg via IFTTT
Control conditions for footwear insole and orthotic research
Publication date: Available online 16 May 2016 Source:Gait & Posture Author(s): Ryan T. Lewinson, Jay T. Worobets, Darren J. Stefanyshyn Footwear insoles/orthotics alter variables associated with musculoskeletal injury; however, their clinical effectiveness is inconclusive. One explanation for this is the possibility that control conditions may actually produce biomechanical changes that induce clinical responses. The purpose… Continue reading Control conditions for footwear insole and orthotic research
Biomarkers for outcome of pembrolizumab-treated patients
Purpose: Biomarkers for outcome after immune-checkpoint blockade are strongly needed as these may influence individual treatment selection or sequence. We aimed to identify baseline factors associated with overall survival (OS) following pembrolizumab treatment in melanoma patients. Experimental design: Serum lactate dehydrogenase (LDH), routine blood count parameters, and clinical characteristics were investigated in 616 patients. Endpoints… Continue reading Biomarkers for outcome of pembrolizumab-treated patients
Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective
Publication date: Available online 16 May 2016 Source:Gait & Posture Author(s): Maryam Hadizadeh, Saidon Bin Amri, Hamidreza Mohafez, Sharifah Roohi Ahmad, Abdul Halim Bin Mokhtar This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty two national athletes with ACL reconstruction and… Continue reading Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective
Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model
Activation of signal transducer and activator of transcription 3 (STAT3) is well known to play a major role in the cell growth, survival, proliferation, metastasis, and angiogenesis of various cancer cells. Most of the citrus species offer large quantities of phytochemicals that have beneficial effects attributed to their chemical components. Our study was carried out… Continue reading Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse... περισσότερα »
Full-field OCT in ovarian tissue
Purpose: Autotransplantation of ovarian tissue can be used to restore fertility in cancer patients following gonadotoxic treatment. Whether this procedure is safe remains unclear, as current tumor detection methods render the ovarian tissue unsuitable for transplantation. Full-field optical coherence tomography (FF-OCT) is an imaging modality that rapidly produces high-resolution histology-like images without the need to… Continue reading Full-field OCT in ovarian tissue
Spatiotemporal, kinematic, force and muscle activation outcomes during gait and functional exercise in water compared to on land: A systematic review
Publication date: Available online 16 May 2016 Source:Gait & Posture Author(s): Sophie Heywood, Jodie McClelland, Paula Geigle, Ann Rahmann, Ross Clark BackgroundExercises replicating functional activities are commonly used in aquatic rehabilitation although it is not clear how the movement characteristics differ between the two environments. A systematic review was completed in order to compare the… Continue reading Spatiotemporal, kinematic, force and muscle activation outcomes during gait and functional exercise in water compared to on land: A systematic review
Exhaustive Genome-Wide Search for SNP-SNP Interactions Across Ten Human Diseases
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Background: The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets. We aimed to use data from the Resource for Genetic Epidemiology Research on Adult Health and Aging (GERA) study to search for SNP-SNP interactions associated with ten common diseases. Methods: FastEpistasis and BOOST were used to evaluate all pairwise interactions among approximately N=300,000 single nucleotide polymorphisms (SNPs) wit... περισσότερα »
mCAL: A New Approach for Versatile Multiplex Action of Cas9 Using One sgRNA and Loci Flanked by a Programmed Target Sequence
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Genome editing exploiting CRISPR/Cas9 has been adopted widely in academia and in the biotechnology industry to manipulate DNA sequences in diverse organisms. Molecular engineering of Cas9 itself and its guide RNA, and the strategies for using them, have increased efficiency, optimized specificity, reduced inappropriate off-target effects, and introduced modifications for performing other functions (transcriptional regulation, high-resolution imaging, protein recruitment, and high-throughput screening). Moreover, Cas9 has the ability to multiplex, *i.e.* to act at different genomic...περισσότερα »
Dynamics of a Novel Highly Repetitive CACTA Family in Common Bean (Phaseolus vulgaris)
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Transposons are ubiquitous genomic components that play pivotal roles in plant gene and genome evolution. We analyzed two genome sequences of common bean (*Phaseolus vulgaris*) and identified a new CACTA transposon family named pvCACTA1. The family is extremely abundant as more than 12,000 pvCACTA1 elements were found. To our knowledge, this is the most abundant CACTA family reported thus far. The computational and fluorescence in situ hybridization (FISH) analyses indicated that the pvCACTA1 elements were concentrated in terminal regions of chromosomes and frequently generated AT ... περισσότερα »
Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Maryam Hadizadeh, Saidon Bin Amri, Hamidreza Mohafez, Sharifah Roohi Ahmad, Abdul Halim Bin Mokhtar This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty two national athletes with ACL reconstruction and 15 healthy athletes were recruited for the study. Gait data were collected between the weeks 4-5, 8-9, and 12-13 post operation using three-dimensional motion analysis system... περισσότερα »
Improvements in spinal alignment after high tibial osteotomy in patients with medial compartment knee osteoarthritis
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Yoon Hyuk Kim, Ariunzaya Dorj, Ahreum Han, Kyungsoo Kim, Kyung Wook Nha Since the correlation between spinal and lower extremity alignments is high, high tibial osteotomy (HTO) surgery may also affect spinal alignment, where the spinal alignment parameters are the most important parameters for the evaluation of spinal disorders. In this study, the effect of HTO surgery on spinal alignment during gait was investigated by comparing spinal alignment parameters between patients with knee osteoarthritis (OA...περισσότερα »
Spatiotemporal, kinematic, force and muscle activation outcomes during gait and functional exercise in water compared to on land: A systematic review
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Sophie Heywood, Jodie McClelland, Paula Geigle, Ann Rahmann, Ross Clark BackgroundExercises replicating functional activities are commonly used in aquatic rehabilitation although it is not clear how the movement characteristics differ between the two environments. A systematic review was completed in order to compare the biomechanics of gait, closed kinetic chain and plyometric exercise when performed in water and on land.MethodsDatabases including MEDLINE, CINAHL, SPORTDiscus, Embase and the Cochrane... περισσότερα »
Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Maryam Hadizadeh, Saidon Bin Amri, Hamidreza Mohafez, Sharifah Roohi Ahmad, Abdul Halim Bin Mokhtar This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty two national athletes with ACL reconstruction and 15 healthy athletes were recruited for the study. Gait data were collected between the weeks 4-5, 8-9, and 12-13 post operation using three-dimensional motion analysis system... περισσότερα »
Control conditions for footwear insole and orthotic research
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Ryan T. Lewinson, Jay T. Worobets, Darren J. Stefanyshyn Footwear insoles/orthotics alter variables associated with musculoskeletal injury; however, their clinical effectiveness is inconclusive. One explanation for this is the possibility that control conditions may actually produce biomechanical changes that induce clinical responses. The purpose of this study was to compare insole/orthotic control conditions to identify if variables at the ground, ankle and knee that are associated with injury, are a... περισσότερα »
Spatiotemporal, kinematic, force and muscle activation outcomes during gait and functional exercise in water compared to on land: A systematic review
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Sophie Heywood, Jodie McClelland, Paula Geigle, Ann Rahmann, Ross Clark BackgroundExercises replicating functional activities are commonly used in aquatic rehabilitation although it is not clear how the movement characteristics differ between the two environments. A systematic review was completed in order to compare the biomechanics of gait, closed kinetic chain and plyometric exercise when performed in water and on land.MethodsDatabases including MEDLINE, CINAHL, SPORTDiscus, Embase and the Cochrane... περισσότερα »
Improvements in spinal alignment after high tibial osteotomy in patients with medial compartment knee osteoarthritis
Publication date: Available online 16 May 2016 *Source:*Gait & Posture Author(s): Yoon Hyuk Kim, Ariunzaya Dorj, Ahreum Han, Kyungsoo Kim, Kyung Wook Nha Since the correlation between spinal and lower extremity alignments is high, high tibial osteotomy (HTO) surgery may also affect spinal alignment, where the spinal alignment parameters are the most important parameters for the evaluation of spinal disorders. In this study, the effect of HTO surgery on spinal alignment during gait was investigated by comparing spinal alignment parameters between patients with knee osteoarthritis (OA...περισσότερα »
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