Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 16 Μαΐου 2016

OtoRhinoLaryngology,New Articles,May 16th,2016,a



OtoRhinoLaryngology - Alexandros G. Sfakianakis
Medication-Related Osteonecrosis of the Jaw
 
 Around Dental Implants: Implant Surgery-Triggered or Implant Presence-Triggered Osteonecrosis?: Introduction: Dentoalveolar surgery including tooth extractions and dental implants placement is considered the major risk factor for developing medication-related osteonecrosis of the jaw (MRONJ).In this...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Buccal Fat Pad for Closure of Oroantral Communication
 
The Buccal Fat Pad for Closure of Oroantral Communication:  Abstract: The buccal fat pad (BFP) is a well-established tool in oral and maxillofacial surgery and its use has proved of value for the closure of oroantral communications. Oroantral communication may be a common complication after sequestrectomy...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pott Puffy Tumor in Children
 
A Rare Emergency Clinical Entity: Objectives: Pott puffy tumor (PPT) is defined as soft tissue swelling of the forehead due to subperiosteal edema, accumulation of pus, or granulation tissue. It is associated with osteomyelitis of frontal bone secondary to frontal sinusitis. Pott puffy tumor can be complicated...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Infection Necrosis After an Extracorporeal Reduction of a Condyle Fracture
 
Infection Necrosis After an Extracorporeal Reduction of a Condyle Fracture: Abstract: The authors experienced a patient of infection necrosis after an extracorporeal reduction of a condyle fracture and reconstructed it with an iliac bone graft.A 37-year-old man visited with a bilateral condyle fracture...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pediatric Sudden Sensorineural Hearing Loss.
 
Pediatric Sudden Sensorineural Hearing Loss.: Sudden sensorineural hearing loss is defined as sudden unilateral or bilateral sensorineural hearing loss with at least 30 dB decrease in threshold in 3 contiguous test frequencies occurring over 72 hours or less. It is rare among children. The mechanism...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Topical Furosemide on Intraoperative Bleeding During Functional Endoscopic Sinus Surgery.
 
Effect of Intraoperative bleeding reduction during functional endoscopic sinus surgery is a key factor in preventing surgery complications. That is implemented through prescribing systemic corticostroid before surgery. This study aimed to explore an efficient nasal Furosemide versus systematic corticosteroids...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Distally Based Perichondrio-Adipo-Dermal Flap Technique for the Correction of Prominent Ear Deformity
 
A New Approach for the Correction of Prominent Ear Deformity: The Distally Based Perichondrio-Adipo-Dermal Flap Technique.: Background: Otoplasty techniques are generally divided into 2 categories as cartilage-cutting and cartilage-sparing. The cartilage-cutting techniques have been criticized because...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Size and Location of the Superior Transverse Ligament and Muscle-Aponeurosis Junction of the Levator Palpebrae Superioris.
 
Size and Location of the Superior Transverse Ligament and Muscle-Aponeurosis Junction of the Levator Palpebrae Superioris.: The aim of this study is to elucidate the size and location of the superior transverse ligament and the muscle-aponeurosis junction (MAJ) of the levator palpebrae superioris.Forty-six...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Level IIB Neck Dissection in Oral Squamous Cell Carcinoma
 
Science or Myth?.: Selective neck dissection enables us to reduce the morbidity of neck dissection while maintaining the same oncological results, mainly in clinically negative neck N0. The most common morbidity associated with selective neck dissection is spinal accessory nerve dysfunction and related...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Endoscopic Fenestration For Middle Fossa Arachnoid Cyst
 
Endoscopic Fenestration of Twenty-Six Patients With Middle Fossa Arachnoid Cyst.: Middle fossa arachnoid cyst (MFAC) is the most common kind of arachnoid cyst. The objective of this study was to assess the efficacy of endoscopic fenestration for MFACs. The authors report 26 patients of MFAC with variety...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Complex Traumatic Facial Degloving Injury.
 
Complex Traumatic Facial Degloving Injury.: By definition, degloving is detachment of skin and subcutaneous tissue, most often affecting the limbs and extremities and occasionally the scalp. Degloving generally occurs from high-energy trauma. This paper describes a patient of traumatic facial degloving...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Palatoplasty in Patients With Isolated Cleft Palate
 
Long-Term Incisal Relationships After Purpose: Various palatoplasty techniques have limited incisions in the hard palate due to concerns that these incisions may limit maxillary growth. There is little convincing long-term evidence to support this. Our purpose is to determine incisal relationships, an...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Aplasia Cutis Congenita of the Scalp With a Skin Allograft
 
Technique for Management of Aplasia cutis congenital is a rare condition presenting with localized or widespread congenital absence of skin, most commonly affecting the scalp. Its management remains controversial due to risks associated with both conservative and surgical approaches. The authors report...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Chronic Rhinosinusitis With Massive Polyposis Causing Proptosis
 
 Requiring Craniofacial Resection.: Chronic rhinosinusitis (CRS) is a common health problem in the Western world. CRS is classified as CRS with (CRSwNP) and without (CRSsNP) nasal polyps. A less common third type is allergic fungal sinusitis, which often presents with polyps and, not infrequently, skull...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cholesteatoma of Maxillary Sinus
 
What Is the Best Surgical Approach?.: Cholesteatoma is a relatively common disease entity within the middle ear or mastoid cavity but cholesteatoma of the paranasal sinuses is a rare diseases entity, especially in the maxillary sinus. As the authors recently experienced a patient of maxillary sinus cholesteatoma,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Anatomy and Histology of an Epicanthal Fold.
 
Anatomy and Histology of an Epicanthal Fold.: The aim of this study is to elucidate the precise anatomical and histological detail of the epicanthal fold.Thirty-two hemifaces of 16 Korean adult cadavers were used in this study (30 hemifaces with an epicanthal fold, 2 without an epicanthal fold). In 2...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Mucocele OR Optic Neuritis
 
Mucocele After Orbital Fracture Repair Masquerading as Optic Neuritis.: The authors report a patient of mucocele formation after orbital wall fracture repair masquerading as optic neuritis.A 38-year-old man with a history of medial orbital wall fracture repair with an alloplastic implant 10 years previously,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Surgery for Obstructive Sleep Apnea Syndrome : Multilevel Combined Surgery With Transoral Robotic Surgery
 
Obstructive Sleep Apnea Syndrome.: Objective: To evaluate the results of combined multilevel surgery with transoral robotic surgery (TORS) in patients with obstructive sleep apnea/hypopnea syndrome for multilevel upper airway obstruction.Methods: Subjects who underwent combined sleep surgery via TORS...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Nager syndrome is a rare condition characterized by craniofacial and upper limb abnormalities
 
The Craniofacial and Upper Limb Management of Nager Syndrome.: Introduction: Nager syndrome is a rare condition characterized by craniofacial and upper limb abnormalities. It is commonly mistaken for Treacher Collins syndrome, with which it shares the same craniofacial phenotype. However, patients with...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Retrieval of a Broken Dental Needle Close to the Facial Artery After Cervical Migration.
 
Retrieval of a Broken Dental Needle Close to the Facial Artery After Cervical Migration.: Use of imaging tools like digital C-arm, tridimensional tomography, and navigational surgery has proven its value to the surgical removal of broken needles. A 32-year-old patient was referred for evaluation of a...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Bone Flap Technique for Impacted Teeth Extraction and Bone Cysts Removal.
 
Bone Flap Technique for Impacted Teeth Extraction and Bone Cysts Removal.: The treatment of cystic lesions and the extraction of impacted third molars are 2 of the most common procedures in oral and maxillofacial surgery. The surgical treatment of cysts of the jaws can consist of a cystectomy, a cystotomy,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Nasal Valve Area: Modified Triangular Spreader Graft.
 
Early Results and Description of a New Modification of Spreader Graft to Enlarge Nasal Valve Area: Modified Triangular Spreader Graft.: Objective: Nasal valve area is an important, functional part of nose and there are several different methods that have been used to enlarge that area for a better breathing...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Dimensions of the Orbital Cavity
 
Based on High-Resolution Computed Tomography of Human Cadavers.: Blow-out fractures affect the volume and surface area of the orbital cavity. Estimation of these values after the trauma may help in deciding whether or not a patient is a candidate for surgery. Recent studies have provided estimates of...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Microscopic Transnasal Approach for the Reconstruction of Frontoethmoidal Meningoencephalocele.
 
Microscopic Transnasal Approach: A New Technique for the Reconstruction of Frontoethmoidal Meningoencephalocele.: Frontoethmoidal meningoencephalocele is a rare congenital malformation, which occurs due to a deficiency in neural tube closure. It may present as an external mass over the nose, nasal obstruction,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Deferoxamine in Distraction Osteogenesis of Irradiated Bone.
 
Clinical Use of The deleterious effects of radiotherapy, including hypovascularity and hypocellularity, have made distraction of irradiated bones challenging. Animal studies, however, have demonstrated adjunctive measures such as the administration of deferoxamine to significantly improve bone regeneration...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Persistent and Recurrent Nasal Obstruction After Primary Septoplasty.
 
The Causes of Objectives: Septoplasty is the most frequently performed surgical procedure in patients with nasal obstruction. However, nasal obstruction may persist or recur after septoplasty in some patients. In this study, the authors aimed to determine the causes of nasal obstruction after septoplasty.Methods:...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Microsurgical Replantation of a Two-Segment Total Scalp Avulsion.
 
Microsurgical Replantation of a Two-Segment Total Scalp Avulsion.: Total scalp avulsion is a rare and severe injury that may be life threatening and can result in devastating disfigurement and psychological trauma. Microsurgical hair-bearing scalp replantation is considered the procedure of choice and...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Whole Rib Harvesting and In Situ Splitting Rib Harvesting Surgery
 
A Study of the Morbidity Involved in Whole Rib Harvesting and In Situ Splitting Rib Harvesting Surgery.: Background: Although there have been several reports that detail the in situ rib splitting harvesting surgical procedure, there are limited published studies evaluating this procedure and the traditional...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Recurrent Nasopharyngeal Mucoepidermoid Carcinoma.
 
Endoscopic Endonasal Resection of Nasopharyngeal mucoepidermoid carcinoma is a rare entity, for which surgical resection is the treatment of choice. The open technique is considered the standard approach, but this often results in significant morbidities such as trismus, dysphagia, and neurologic deficits....
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection
 
Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial: AbstractObjectivesIn this single-blinded, prospective, randomized, controlled clinical trial, the effectiveness of an ozone gas or NaOCl/CHX...

OtoRhinoLaryngology - Alexandros G. Sfakianakis
Skeletal stability with the bilateral sagittal split osteotomy when used for mandibular advancement surgery
 
Are bicortical screw and plate osteosynthesis techniques equal in providing skeletal stability with the bilateral sagittal split osteotomy when used for mandibular advancement surgery? A systematic review and meta-analysisvia Oral and Maxillofacial SurgeryPublication date: Available online May 2016Source:International...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Modified Oblique Le Fort III Osteotomy
 
New Concepts: AbstractIntroductionThe purpose of this study is to demonstrate the surgical technique for the correction of midfacial deformities; vertical excess and posteroanterior hypoplasia. This situation obligates the need to move the whole osseous structure in an oblique posteroanterior movement...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The mTOR pathway in intraoral minor salivary gland neoplasms
 
Immunohistochemical evaluation of by S Diamanti, N Nikitakis, G Rassidakis, I Doulis, A Sklavounou via Oral DiseasesAbstractObjectivesThe aim of this study was to investigate the expression of upstream and downstream molecules of the oncogenic mTOR signaling pathway in intraoral minor salivary gland...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Sialendoscopy and sialendoscopically-assisted operations
 
 in the treatment of lithiasis of the submandibular and parotid glands: our experience of 239 casesvia British Journal of Oral and Maxillofacial SurgeryPublication date: Available online May 2016Source:British Journal of Oral and Maxillofacial SurgeryAuthor(s): Tomasz Kopeć, Małgorzata Wierzbicka, Jarosław...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Primary signet-ring cell adenocarcinoma of the head and neck
 
: a case study and brief reviewvia British Journal of Oral and Maxillofacial SurgeryPublication date: Available online May 2016Source:British Journal of Oral and Maxillofacial SurgeryAuthor(s): Shofiq Islam, Keith Jones, David LaugharneWe present a patient who had an aggressive primary signet-ring cell...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Brain Abscess Potentially Resulting from Odontogenic Focus
 
Report of Three Cases and a Literature Review: AbstractIntroductionOdontogenic foci can rarely cause intracranial infection. Hematogenous spread is considered to be the most important pathophysiological mechanism of intracranial infection of odontogenic origin. To investigate the oral origin of intracranial...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Bilateral Parotid Sialadenosis Associated with Long-Standing Bulimia
 
A Case Report and Literature Review: AbstractPurposeBulimia is a common cause of sialadenosis. This paper presents a case of bilateral parotid sialadenosis associated with long-standing bulimia, and reviews the relevant literature and current treatment options.Methods and ResultsA 32-year-old woman had...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Microvascular reconstruction: Perioperative risk factors for postoperative pulmonary complications
 
 after major oral and maxillofacial surgery with microvascular reconstruction: a retrospective analysis of 648 casesvia ScienceDirect Publication: Journal of Cranio-Maxillofacial SurgeryPublication date: Available online 14 May 2016Source:Journal of Cranio-Maxillofacial SurgeryAuthor(s): Denys J. Loeffelbein,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Mandibular Angle Fractures
 
A Detailed Analysis of Mandibular Angle Fractures: Epidemiology, Patterns, Treatments, and Outcomesvia Oral and Maxillofacial SurgeryPublication date: Available online May 2016Source:Journal of Oral and Maxillofacial SurgeryAuthor(s): Neel Patel, Beomjune Kim, Waleed ZaidObjectiveThe purpose was to analyze...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Postoperative pulmonary complications (PPCs)
 
Perioperative risk factors for postoperative pulmonary complications after major oral and maxillofacial surgery with microvascular reconstruction: a retrospective analysis of 648 cases: Postoperative pulmonary complications (PPCs) are common and result in prolonged hospital stays, higher costs and increased...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
“Bone Mapping/Sketching” in Management of Anterior Table Frontal Sinus Fracture
 
“Bone Mapping/Sketching” in Management of Anterior Table Frontal Sinus Fracture: AbstractPurposeThe aim of this present article was to know the efficacy of bone mapping/sketching in management of anterior table frontal sinus fracture.Material and methodsThis prospective clinical study includes 10 patients...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The usefulness of intra-operative visualisation, endoscopic assistance, and CT measurements for estimating the orbital fracture size and complexity
 
How reliable is the visual appraisal of a surgeon for diagnosing orbital fractures?via ScienceDirect Publication: Journal of Cranio-Maxillofacial SurgeryPublication date: Available online 14 May 2016Source:Journal of Cranio-Maxillofacial SurgeryAuthor(s): Leander Dubois, Jesper Jansen, Ruud Schreurs,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Giant Cell Tumors in Temporomandibular Joint Region Involving Lateral Skull Base
 
Surgical Management of via Oral and Maxillofacial SurgeryPublication date: Available online 14 May 2016Source:Journal of Oral and Maxillofacial SurgeryAuthor(s): Yi Shen, Chunyue Ma, Liang Wang, Jun Li, Yiqun Wu, Jian SunPurposeGiant cell tumors (GCTs) in the temporomandibular joint (TMJ) region invading...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Pedicled Buccal Fat Pad (BFP) in The Closure of A Large Oro-Antral Fistula (OAF)
 
Long-Term Effectiveness of via Oral and Maxillofacial SurgeryPublication date: Available online 14 May 2016Source:Journal of Oral and Maxillofacial SurgeryAuthor(s): Emad T. DaifPurposeThis study was carried out to evaluate the long-term effectiveness of the pedicled buccal fat pad (BFP) in the closure...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The orbital compartment syndrome
 
The “tight orbit”: Incidence and management of the orbital compartment syndrome: The orbital compartment syndrome (OCS) constitutes a severe emergency, requiring immediate clinical diagnosis and surgical decompression. The key symptom is progressive visual impairment caused by an increase in intraorbital...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The treatment of unilateral cleft lip and palate
 
Evolution of my philosophy in At the end of 50-year-long clinical activity, the evolution of my approach to the treatment of unilateral cleft of the lip and palate is discussed. I had several teachers in this field (Rusconi, Reherman, Perko, Delaire, Talmant, Sommerlad and others) and I introduced in...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Metastatic solid tumors to the jaw and oral soft tissue
 
A retrospective clinical analysis of 44 patients from a single institution: Metastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution’s...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Recurrent Multilocular Mandibular Giant Cell Granuloma in Neurofibromatosis Type 1
 
Evidence for Second Hit Mutation of NF1 Gene in the Jaw Lesion and Treatment with Curettage and Bone Substitute Materials: Giant cell granuloma (GCG) of the jaw is a rare, well-known feature of neurofibromatosis type 1 (NF1), an inborn multisystem disorder. Recently, the development of GCG in NF1 was...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Lidocaine/clonidine for inferior alveolar nerve block
 
Anaesthetic efficacy of lidocaine/clonidine for inferior alveolar nerve block in patients with irreversible pulpitis: AbstractAimsThis prospective, randomized, double-blind study aimed to compare the efficacy of lidocaine with epinephrine versus lidocaine with clonidine for inferior alveolar nerve block...

OtoRhinoLaryngology - Alexandros G. Sfakianakis
Implant surface design on early bone anchorage in the presence of hyperglycemia
 
Early Bone Anchorage to Micro- and Nano-topographically Complex Implant Surfaces in Hyperglycemiavia Acta BiomaterialiaPublication date: Available online May 2016Source:Acta BiomaterialiaAuthor(s): Elnaz Ajami, Spencer Bell, Robert S. Liddell, John E. DaviesThe aim of this work was to investigate the...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Additive manufactured polymeric objects
 
Production tolerance of additive manufactured polymeric objects for clinical applicationsvia Dental MaterialsPublication date: Available online 24 April 2016Source:Dental MaterialsAuthor(s): Michael Braian, Ryo Jimbo, Ann WennerbergObjectivesTo determine the production tolerance of four commercially...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Leptomeningeal metastases from epithelial tumors
 
EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors: BackgroundModerate diagnostic accuracy of MRI and initial cerebrospinal fluid (CSF) cytology analysis results in at least 10%–15% false negative diagnoses of leptomeningeal...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Differentiating brain tumor progression from radiation injury after cranial irradiation
 
A prospective trial of dynamic contrast-enhanced MRI perfusion and fluorine-18 FDG PET-CT in : BackgroundThe aim of this study was to assess the effectiveness of fluorine-18 fluorodeoxyglucose (FDG) PET-CT and dynamic contrast-enhanced (DCE) MRI in differentiating tumor progression and radiation injury...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Hypofractionated stereotactic radiotherapy for brain metastases
 
 from lung cancer: AbstractAimTo evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) for brain metastases (BMs) from lung cancer, and to explore prognostic factors associated with local control (LC) and indication.Patients and methodsWe evaluated patients who were...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma
 
Phase I safety and pharmacokinetic dose-escalation study of AbstractPurposePilaralisib (SAR245408), a pan-class I PI3K inhibitor, has been investigated in Phase I/II trials in several solid tumors and lymphomas in capsule and tablet formulations of polymorph A (capsule-A and tablet-A). This Phase I study...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Mucosal melanoma (MM)
 
Retrospective multicenter evaluation of patients diagnosed with mucosal melanoma: a study of Anatolian Society of Medical Oncologyvia Tumor BiologyAbstractMucosal melanoma (MM) is a rare type of cancer that differs significantly from cutaneous melanoma. In this study, we aimed to evaluate clinical and...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Treatment patterns of advanced malignant melanoma
 
 (stage III–IV) – A review of current standards in Europevia ScienceDirect Publication: European Journal of CancerPublication date: June 2016Source:European Journal of Cancer, Volume 60Author(s): Mark Harries, Josep Malvehy, Céleste Lebbe, Louise Heron, Justyna Amelio, Zsolt Szabo, Dirk SchadendorfAims...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Peritonitis following percutaneous gastrostomy tube insertions in children
 
Peritonitis following percutaneous gastrostomy tube insertions in children: AbstractBackgroundPercutaneous retrograde gastrostomy has a high success rate, low morbidity, and can be performed under different levels of sedation or local anesthesia in children. Despite its favourable safety profile, major...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
NPC : MicroRNAs serving as potential biomarkers and therapeutic targets
 
 in nasopharyngeal carcinoma: A critical reviewvia Critical Reviews in Oncology/Hematology (open access)Publication date: Available online May 2016Source:Critical Reviews in Oncology/HematologyAuthor(s): Katherine Ting-Wei Lee, Juan-King Tan, Alfred King-yin Lam, Sook-Yee GanDespite significant medical...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Treatment of cerebral radiation necrosis with nerve growth factor
 
 A prospective, randomized, controlled phase II study: A prospective, placebo controlled phase II trial was conducted to test the efficacy of Nerve Growth Factor (NGF) for the treatment of symptomatic temporal lobe necrosis (TLN).AbstractPurposeA prospective, placebo controlled phase II trial was conducted...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Ingenol mebutate 0.015 % gel
 
http://www.rxlist.com/picato-drug/Picato® (ingenol mebutate) gel, 0.015% or 0.05% is a clear colorless gel for topical administration, which contains the active substance ingenol mebutate, an inducer of cell death.The chemical name of ingenol mebutate is: 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Human papillomavirus DNA and p16(INK4a) expression in hypopharyngeal cancer
 
 and in relation to clinical outcome, in Stockholm, Sweden.: Authors: Dalianis T, Grün N, Koch J, Vlastos A, Tertipis N, Nordfors C, Näsman A, Wendt M, Romanitan M, Bersani C, Munck-Wikland E, Ramqvist TAbstract OBJECTIVES: Hypopharyngeal cancer is a subset of head neck squamous cell carcinoma...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Eccrine syringofibroadenomatosis (ESFA), it can be mistaken for granulomatous infections or malignancies such as squamous cell carcinoma
 
Eccrine syringofibroadenomatosis of the reactive subtype occurring in chronic poorly-controlled psoriasis.: Authors: Heng YK, Pan JY, Tan SH, Tey HLAbstract Eccrine syringofibroadenomatosis (ESFA) is a rare adnexal tumor with acrosyringeal differentiation. Clinically, it can be mistaken for...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pathway Analysis using Gene-expression Profiles of HPV-positive and HPV-negative Oropharyngeal Cancer
 
Patients in a Hispanic Population: Methodological Procedures.P R Health Sci J. 2016;35(1):3-8Authors: Suárez E, González L, Pérez-Mitchell C, Ortiz AP, Ramírez-Sola M, Acosta J, Bernabe-Dones RD, González-Aquino C, Montes-Rodríguez I, Cadilla CLAbstractOBJECTIVE: The incidence of oral cavity and pharyngeal...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Identification of More Feasible MicroRNA-mRNA Interactions within Multiple Cancers
 
Using Principal Component Analysis Based Unsupervised Feature ExtractionInt J Mol Sci. 2016;17(5)Authors: Taguchi YHAbstract MicroRNA(miRNA)-mRNA interactions are important for understanding many biological processes, including development, differentiation and disease progression, but their identification...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma
 
 in vitro and in vivoMol Med Rep.Authors: Li X, Li Z, Yang G, Pan ZAbstract Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal squamous cell carcinoma (ESCC) and are crucial in tumorigenesis, among which miR‑338‑3p has been examined to be downregulated...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation.
 
Authors: Li LY, Jiang H, Xie YM, Liao LD, Cao HH, Xu XE, Chen B, Zeng FM, Zhang YL, Du ZP, Chen H, Huang W, Jia W, Zheng W, Xie JJ, Li EM, Xu LYAbstract The paucity of new drugs for the treatment of esophageal squamous cell carcinoma (ESCC) limits the treatment options. This study characterized...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Double primary malignant fibrous histiocytoma and squamous cell carcinoma of the larynx
 
 treated with laser laryngeal conservation surgeryEcancermedicalscience. 2016;10:636Authors: Karkos PD, Dova S, Sotiriou S, Markou K, Kostopoulos IAbstract ΒACKGROUND: Synchronous multiple malignancies of the larynx are rare. We present a case here of synchronous primary laryngeal squamous cell...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Prognostic genetic sequence variants in the MAP-kinase and hormone pathways.
 
A genome-wide association study of non-HPV-related head and neck squamous cell carcinoma identifies prognostic genetic sequence variants in the MAP-kinase and hormone pathwaysCancer Epidemiol. 2016 May;42:173-180Authors: Azad AK, Bairati I, Qiu X, Girgis H, Cheng L, Waggott D, Cheng D, Mirshams M, Ho...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC)
 
Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population: AbstractAimThe aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC).Materials...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Severe prolonged dysphagia following transoral resection of bilateral synchronous tonsillar carcinoma.
 
Authors: Patel AB, Hinni ML, Pollei TR, Hayden RE, Moore EJAbstract OBJECTIVES: Alert the reader to the complication of severe dysphagia following transoral laser microsurgery (TLM) or transoral robotic surgery (TORS) for bilateral simultaneous or synchronous tonsillar squamous cell carcinoma....
OtoRhinoLaryngology - Alexandros G. Sfakianakis
RRx-001, A novel dinitroazetidine radiosensitizer
 
RRx-001, A novel dinitroazetidine radiosensitizer: SummaryThe ‘holy grail’ in radiation oncology is to improve the outcome of radiation therapy (RT) with a radiosensitizer—a systemic chemical/biochemical agent that additively or synergistically sensitizes tumor cells to radiation in the absence of significant...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
α 2 integrin inhibitor E7820 in patients with advanced solid tumors
 
A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of SummaryIntroduction E7820 is an orally administered sulfonamide that inhibits alfa-2-integrin mRNA expression. Pre-clinically E7820 showed tumor anti-angiogenic effects in various tumor cell lines and xenograft mouse...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in advanced solid tumors
 
Phase 1 study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced solid tumorsSummaryBackground This phase I study evaluated the safety and tolerability, pharmacokinetics and pharmacodynamics, immunogenicity, and antitumor activity of pembrolizumab in Japanese...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Investigational New Drugs
 
Successful human epidermal growth receptor 2-targeted therapy beyond disease progression for extramammary Paget’s diseaseSummaryExtramammary Paget’s disease is a malignant intraepithelial carcinoma, which constitutes less than 1 % of all vulvar malignancies. Surgical resection is the first treatment...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Dacomitinib (pan-HER tyrosine kinase inhibitor) in patients with locally advanced head and neck squamous cell carcinoma (LA SCCHN)
 
Pharmacokinetic assessment of dacomitinib (pan-HER tyrosine kinase inhibitor) in patients with locally advanced head and neck squamous cell carcinoma (LA SCCHN) following administration through a gastrostomy feeding tube (GT).: Authors: Chiu JW, Chan K, Chen EX, Siu LL, Abdul Razak ARAbstract ...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cervical nodal level V can safely be omitted in the treatment of locally advanced oropharyngeal squamous cell carcinoma with definitive IMRT
 
Cervical nodal level V can safely be omitted in the treatment of locally advanced oropharyngeal squamous cell carcinoma with definitive IMRT: Intensity modulated radiotherapy (IMRT) has emerged as the favored radiation modality for the definitive and post operative treatment of locally advanced head...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Field treatment of actinic keratosis with ingenol mebutate 0.015 % gel
 
Efficacy, safety and tolerability of field treatment of actinic keratosis with ingenol mebutate 0.015 % gel: a single center case series: AbstractIntroductionActinic keratosis (AK) is a cutaneous intraepithelial neoplasm appearing within areas referred as ‘fields of cancerization’. AK can progress to...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Post-chemoradiotherapy superselective/selective neck dissection
 
Impact of post-chemoradiotherapy superselective/selective neck dissection on patient reported quality of lifevia ScienceDirect Publication: Oral OncologyPublication date: July 2016Source:Oral Oncology, Volume 58Author(s): Kyle Wang, Robert J. Amdur, William M. Mendenhall, Rebecca Green, Shannon Aumer,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The association between phosphodiesterase type 5 inhibitors (PDE5-Is), drugs used in the treatment of erectile dysfunction (ED), and melanoma skin cancer
 
Phosphodiesterase Type 5 Inhibitors and the Risk of Melanoma Skin CancerEur Urol. 2016 May ;Authors: Lian Y, Yin H, Pollak MN, Carrier S, Platt RW, Suissa S, Azoulay LAbstract BACKGROUND: The association between phosphodiesterase type 5 inhibitors (PDE5-Is), drugs used in the treatment of erectile...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cutaneous manifestations associated with malignancy of the head and neck.
 
Cutaneous manifestations associated with malignancy of the head and neckSemin Oncol. 2016 Jun;43(3):353-8Authors: Lorimer P, Milas ZAbstract Most cutaneous malignancies of the head and neck (HN) are non-melanoma skin cancers, predominantly basal cell carcinomas (BCCs) and squamous cell carcinomas...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Erlotinib in Head and Neck Squamous Cell Carcinoma Cells.
 
2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Oncol Res. 2016;24(1):55-64Authors: Sobhakumari A, Orcutt KP, Love-Homan L, Kowalski CE, Parsons AD, Knudson CM, Simons ALAbstract Poor tumor response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Radiation therapy, cetuximab and pemetrexed with or without bevacizumab in patients with locoregionally-advanced head and neck cancer.
 
Phase II randomized trial of Ann Oncol. 2016 May 13;Authors: Argiris A, Bauman JE, Ohr J, Gooding WE, Heron DE, Duvvuri U, Kubicek GJ, Posluszny DM, Vassilakopoulo M, Kim S, Grandis JR, Johnson JT, Gibson MK, Clump DA, Flaherty JT, Chiosea SI, Branstetter B, Ferris RLAbstract BACKGROUND: We previously...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Non-epithelial tumors of the larynx
 
a single institution reviewAm J Otolaryngol. 2016 May-Jun;37(3):279-85Authors: Karatayli-Ozgursoy S, Bishop JA, Hillel AT, Akst LM, Best SRAbstract AIM: Non-epithelial tumors of the larynx are rare and encompass a wide range of pathology. We present the decade-long experience of a single institution...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Outcome of heavily pretreated recurrent oral squamous cell carcinoma after salvage resection: A monocentric retrospective analysis
 
Outcome of heavily pretreated recurrent oral squamous cell carcinoma after salvage resection: A monocentric retrospective analysis: The goals of the present study were to analyze survival data of patients who received salvage surgery due to recurrent oral squamous cell carcinoma (OSCC) of the oral cavity...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Bbilateral cochlear implantation in congenitally deaf children
 
The effect of device use after sequential bilateral cochlear implantation in children: An electrophysiological approachvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Marloes Sparreboom,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Wideband reflectance measurements in newborns
 
: Relationship to otoscopic findingsvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Jacob Pitaro, Laila Al Masaoudi, Hamid Motallebzadeh, W. Robert J. Funnell, Sam J. DanielObjectivesNewborn...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Post-intubation acute laryngeal injuries in infants and children
 
: A new classification systemvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Cláudia Schweiger, Denise Manica, Gabriel Kuhl, Leo Sekine, Paulo José Cauduro MarosticaObjectiveTo compare...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Serum eosinophilia and total immunoglobulin E concentration with the risk of allergic symptoms and allergic sensitization
 
Association of serum eosinophilia and total immunoglobulin E concentration with the risk of allergic symptoms and allergic sensitization, respectively: A 2-year follow-up studyvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The treatment of tympanostomy tube otorrhea
 
Topical versus oral antibiotics, with or without corticosteroids, in via International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Jeremy Chee, Khang Wen Pang, Jui May Yong, Roger Chun-Man Ho, Raymond...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Olfactory function in children with rhinitis
 
Evaluation of olfactory function in children with allergic rhinitis and nonallergic rhinitisvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Seyhan Kutlug, Emre Gunbey, Ayhan Sogut,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Detection of Helicobacter
 
Routine Anti-Helicobacter Immunohistochemical Staining is Significantly Superior to Reflex Staining Protocols for the Detection of Helicobacter in Gastric Biopsy Specimens: AbstractBackgroundThe role of special stains in the detection of H. pylori is controversial; some pathologists claim that hematoxylin...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Surgery for persistent pediatric tracheocutaneous fistula
 
Systematic review of ObjectivesTo compare the treatment outcomes and adverse event rates for primary closure compared to simple excision with healing by secondary intention for persistent tracheocutaneous fistula (TCF) in children.Study DesignSystematic review.MethodsSystematic review using Preferred...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The management of the middle vault in rhinoplasty.
 
Update in the management of the middle vault in rhinoplasty.: Purpose of review: The middle vault of the nose continues to be a topic of interest among surgeons interested in aesthetic and functional rhinoplasty. The purpose of this review is to present currently accepted concepts regarding the significance...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Laryngeal Mucous Membrane Pemphigoid
 
Assessment and Management of Laryngeal Mucous Membrane Pemphigoid: Our Experience in Six Patients and a Proposed Severity Scale: Mucous membrane pemphigoid (MMP) comprises a heterogenous spectrum of rare subepithelial blistering disorders affecting characteristic tissues throughout the body1. The prevalence...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The vertical juxtaposition junction flap – a useful flap in mastoid obliteration
 
Our long-term experience in twenty patients: The vertical juxtaposition junction (VJJ) flap is a useful adjunct to the technique of mastoid obliteration and is readily created during the process of cartilage graft harvesting from the conchal bowl.It allows for greater inward rotation of a Palva flap...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
he diagnostic value of laryngeal stroboscopy in excluding early glottic carcinoma
 
Systematic review of the diagnostic value of laryngeal stroboscopy in excluding early glottic carcinoma:AbstractObjectiveLaryngeal stroboscopy is an important diagnostic tool in the work-up of patients with phoniatric complaints. The aim of this article is to evaluate the diagnostic value of laryngeal...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Unstimulated whole saliva (UWS) sialometry
 
The effect of clinical setting on the unstimulated salivary flow ratevia Oral BiologyPublication date: September 2016Source:Archives of Oral Biology, Volume 69Author(s): Elena Maria Varoni, Veronica Federighi, Sem Decani, Antonio Carrassi, Giovanni Lodi, Andrea SardellaObjectiveUnstimulated whole saliva...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
S tudy of Ulcero-membranous Lesions of Tonsil in an Indian Scenario
 
S tudy of Ulcero-membranous Lesions of Tonsil in an Indian Scenario: Abstract‘Ulcero-membranous lesions over tonsil’ is a special entity, which puzzles every physician and surgeon because of it’s diverse etiology. Every insult to the tonsil heals by ulcer and later membrane formation. A retrospective...

OtoRhinoLaryngology - Alexandros G. Sfakianakis
Use of the Laparoscopic Bipolar Vessel Sealing System in Endoscopic Laryngeal Surgery
 
The Novel Use of the Laparoscopic Bipolar Vessel Sealing System in Endoscopic Laryngeal Surgery: Laryngeal Cyst ResectionThis is “Laryngeal Cyst Resection” by on Vimeo, the home for high quality videos and the people who love them.Jay K. Ferrell, MD; Benjamin Yang, MD; Uma Ramaswamy, MD; Ronda E. Alexander,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Frequency-specific hearing assessment noise
 
FRESH Noise - A Fresh Approach to Pediatric Testing: Keeley Moore: FRESH noise, or frequency-specific hearing assessment noise, is a narrowband noise (NBN) stimulus designed for the purpose of measuring hearing thresholds. It is frequency specific due to extremely steep filter slopes. Because of these...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
FRESH Noise - A Fresh Approach to Pediatric Testing
 
Keeley Moore: FRESH noise, or frequency-specific hearing assessment noise, is a narrowband noise (NBN) stimulus designed for the purpose of measuring hearing thresholds. It is frequency specific due to extremely steep filter slopes. Because of these steeply sloping filters slopes, the stimulus does not...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Colonic overexpression of the T-type calcium channel Cav3.2 in a mouse model of visceral hypersensitivity and in irritable bowel syndrome patients
 
Abstract Background Among the different mechanisms involved in irritable bowel syndrome (IBS) physiopathology, visceral hypersensitivity seems to play a key role. It involves sensitization of the colonic primary afferent fibers, especially through an overexpression of ion channels. The aims of...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Gastric peroral endoscopic pyloromyotomy (G-POEM) as a salvage therapy for refractory gastroparesis: a case series of different subtypes
 
Abstract Background Gastroparesis is a poorly understood, chronic, debilitating motility disorder with very limited medical therapeutic options. Gastric peroral endoscopic pyloromyotomy (G-POEM) is an emerging novel endoscopic technique as an incisionless pyloroplasty for refractory cases. Effective...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
The Novel Use of the Laparoscopic Bipolar Vessel Sealing System in Endoscopic Laryngeal Surgery
 
Laryngeal Cyst Resection This is "Laryngeal Cyst Resection" by on Vimeo, the home for high quality videos and the people who love them. Jay K. Ferrell, MD; Benjamin Yang, MD; Uma Ramaswamy, MD; Ronda E. Alexander, MD Ibrahim Alava III, MD Objective: To report our preliminary experience highlighting...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
The effects of second generation antipsychotic drugs on sleep variables in healthy subjects and patients with schizophrenia
 

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