BacterioFiles 257 - Phage Fibers Fight Phyllosphere Foes
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
This episode: Bacteria have repeatedly captured and used the tails of phages to fight each other! (9 MB, 9.8 minutes) Show notes: Journal Paper: Hockett KL, Renner T, Baltrus DA. 2015. http://ift.tt/28XBxqT
Cochlear Implantation
Alternative Techniques in Özgür Sürmelioğlu 1 , Süleyman Özdemir 1 , Özgür Tarkan 1 , Ülkü Tuncer 1 , Fikret Çetik 1 , Karahan Kara 1 , Mete Kıroğlu 1 J Int Adv Otol 2016; 12: 109-112 DOI: 10.5152/iao.2015.1022 Abstract *OBJECTIVE*: To review the alternative techniques in cochlear implantation and to compare the complications with different techniques. * MATERIALS and METHODS*: Patients who had undergone cochlear implantation were reviewed. Those patients who were operated using alternative techniques were selected and evaluated for the cause of their hearing loss ... περισσότερα »
Eustachian Tube Dysfunction Questionnaire
Responsiveness of the 7-item Shari Van Roeyen 1 , Paul Van de Heyning 1 , Vincent Van Rompaey 1 1 Antwerp University Hospital, Otorhinolaryngology and Head and Neck Surgery, Edegem, Belgium; University of Antwerp, School of Medicine and Health Sciences, Wilrijk, Belgium J Int Adv Otol 2016; 12: 106-108 DOI: 10.5152/iao.2016.2086 Abstract *OBJECTIVE*: Baro-challenge-induced Eustachian tube (ET) dysfunction is defined as the presence of aural discomfort, popping, or pain, which only arises in case of ambient pressure changes, without abnormalities on otoscopy or tympanometry... περισσότερα »
Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo
The Role of Mehmet Taylan Güçlütürk 1 , Zeynep Nil Ünal 2 , Onur İsmi 1 , Mehmet Burak Yavuz Çimen 3 , Murat Ünal 1 1 Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey 2 Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey 3 Department of Medical Biochemistry, Mersin University School of Medicine, Mersin, Turkey J Int Adv Otol 2016; 12: 101-105 DOI: 10.5152/iao.2015.1412 Abstract *OBJECTIVE*: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined ... περισσότερα »
BacterioFiles 257 - Phage Fibers Fight Phyllosphere Foes
This episode: Bacteria have repeatedly captured and used the tails of phages to fight each other! (9 MB, 9.8 minutes) Show notes: Journal Paper: Hockett KL, Renner T, Baltrus DA. 2015. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/28XBxqT via IFTTT
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/297xR5r via IFTTT
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/297xR5r via IFTTT
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus
Summary Objective To determine the bioequivalence of brivaracetam oral tablet formulations (10, 75, and 100 mg) versus 50 mg oral tablet and to compare the bioavailability of brivaracetam 100 mg intravenous (i.v.) bolus versus 50 and 100 mg tablets, in healthy participants. Methods Phase 1, randomized, open-label, five-period crossover study. Participants received five single doses of brivaracetam: 10, 50 (reference), 75, and 100 mg oral tablets; 100 mg, i.v., bolus injection. Pharmacokinetic parameters (maximum plasma concentration [Cmax], area under the plasma concentration-time ... περισσότερα »
Plasma taurine levels are not affected by vigabatrin in pediatric patients
Summary Vigabatrin is a highly effective antiseizure medication, but its use is limited due to concerns about retinal toxicity. One proposed mechanism for this toxicity is vigabatrin-mediated reduction of taurine. Herein we assess plasma taurine levels in a retrospective cohort of children with epilepsy, including a subset receiving vigabatrin. All children who underwent a plasma amino acid analysis as part of their clinical evaluation between 2006 and 2015 at Stanford Children's Health were included in the analysis. There were no significant differences in plasma taurine levels bet... περισσότερα »
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus
Summary Objective To determine the bioequivalence of brivaracetam oral tablet formulations (10, 75, and 100 mg) versus 50 mg oral tablet and to compare the bioavailability of brivaracetam 100 mg intravenous (i.v.) bolus versus 50 and 100 mg tablets, in healthy participants. Methods Phase 1, randomized, open-label, five-period crossover study. Participants received five single doses of brivaracetam: 10, 50 (reference), 75, and 100 mg oral tablets; 100 mg, i.v., bolus injection. Pharmacokinetic parameters (maximum plasma concentration [Cmax], area under the plasma concentration-ti... περισσότερα »
Developing and pilot testing an electronic medical record–based allergen immunotherapy template
Decision support and health information technologies, such as electronic medical record (EMR) systems, have been reported to enhance the quality and efficiency of medical care.1,2 EMR systems are increasingly being used by allergy/immunology physicians to facilitate clinical documentation surrounding office visits and allergen immunotherapy (AIT). Although distinct EMR programs are available, each platform typically enables customizable features to fit specialty-specific needs.3 Allergy-specific EMR systems may be used to document skin test results and manage AIT schedules and adm... περισσότερα »
The kinetics and protection of the antiviral state induced by recombinant iIFN1a in rainbow trout against infectious hematopoietic necrosis virus
Publication date: August 2016 *Source:*Molecular Immunology, Volume 76 Author(s): Yongsheng Cao, Liming Xu, Scott E. LaPatra, Jingzhuang Zhao, Miao Liu, Hongbai Liu, Tongyan Lu, Qiya Zhang The iIFN1a (intracellular IFN-a1), that is one of the IFN-a1 variants, was shown to be functional intracellularly and act as a novel defense against an infectious hematopoietic necrosis virus (IHNV). To determine its antiviral properties, a recombinant iIFN1a was generated in Escherichia coli. Its antiviral activity against IHNV was 1.69×107U/mg in CHSE-214 cells. Additionally, iIFN1a was capable ... περισσότερα »
EDITORIAL
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/28Yo1Wd
Masthead - Editorial Board And Table of Contents
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/28SaETT
MZ B cells migrate in a T-bet dependent manner and might contribute to the remission of collagen-induced arthritis by the secretion of IL-10
In mice, marginal zone (MZ) B cells are found principally in the MZ of the spleen and characterized as CD23-negative cells, primarily express polyreactive BCRs, high levels of complement receptor-2 and toll-like receptors (TLRs). Collagen-induced arthritis (CIA) is a commonly used animal model of human rheumatoid arthritis, considered as a Th1-mediated disease. Although the importance of MZ B cells in the initiation of CIA is well established, their role in remission is unexplored. Besides, playing a central role in Th1 cell development, T-bet has important functions in B cells. ... περισσότερα »
Opposing roles of TGF-β in prostaglandin production by human follicular dendritic cell-like cells
Publication date: August 2016 *Source:*Molecular Immunology, Volume 76 Author(s): Jongseon Choe, Jihoon Park, Seungkoo Lee, Young-Myeong Kim, Dooil Jeoung Prostaglandins (PGs) are recognized as important immune regulators. Using human follicular dendritic cell (FDC)-like HK cells, we have investigated the immunoregulatory role of PGs and their production mechanisms. The present study was aimed at determining the role of TGF-β in IL-1β-induced cyclooxygenase-2 (COX-2) expression by immunoblotting. COX-2 is the key enzyme responsible for PG production in HK cells. TGF-β, when added s... περισσότερα »
CD209 promoter polymorphisms associate with HCV infection and pegylated-interferon plus ribavirin treatment response
Publication date: August 2016 *Source:*Molecular Immunology, Volume 76 Author(s): Luisa Zupin, Vania Polesello, Giulia Alberi, Giulia Moratelli, Saveria Lory Crocè, Flora Masutti, Gabriele Pozzato, Sergio Crovella, Ludovica Segat Hepatitis C is a severe liver disease caused by hepatitis C virus that could persist in the host causing progression towards chronic disease in about 80% of the cases. Pegylated-interferon plus ribavirin was the gold standard therapy, however treatment's response was quite variable among individuals and different host/viral factors may play a role in diseas... περισσότερα »
FoxP3 Expression in Macrophages, Cancer, and B Cells—Is It Real?
Abstract During the last decade, B regulatory cells are appreciated to have a central role in preventing autoimmunity and maintaining self-tolerance. They are characterized by expressing different phenotypic markers and the production of either IL-10 or TGF-β or both. The recent recognition of Fas ligand expressing B regulatory cells as "killer" cells established their role in maintaining viral persistence by preventing effective antiviral immune responses. The forkhead lineage-transcription factor (FoxP3) was considered for many years to be a highly specific intracellular regulato... περισσότερα »
Significance of Interleukin-6/STAT Pathway for the Gene Expression of REG Iα, a New Autoantigen in Sjögren’s Syndrome Patients, in Salivary Duct Epithelial Cells
Abstract The regenerating gene, *Reg*, was originally isolated from a rat regenerating islet complementary DNA (cDNA) library, and its human homologue was named *REG Iα*. Recently, we reported that *REG Iα* messenger RNA (mRNA), as well as its product, was overexpressed in ductal epithelial cells in the salivary glands of Sjögren's syndrome patients. Furthermore, autoantibodies against REG Iα were found in the sera of Sjögren's syndrome patients, and the patients who were positive for the anti-REG Iα antibody showed significantly lower saliva secretion than antibody-negative patie... περισσότερα »
High-dose bee venom exposure induces similar tolerogenic B cell responses in patients and healthy beekeepers
[image: cover.gif?v=1&s=1c0829f67154291c71477225] Abstract Background The involvement of B cells in allergen tolerance induction remains largely unexplored. This study investigates the role of B cells in allergen tolerance induction to high-dose allergen exposure, and to compare B cell responses between allergic patients receiving allergen immunotherapy (AIT) and naturally exposed healthy beekeepers before and during the beekeeping season. Methods Circulating B cells were characterized by flow cytometry. PLA-specific B cells were identified using dual color staining with fluore... περισσότερα »
Esophageal Epithelial Biology.
A Zebrafish Model for Studies on Esophageal Epithelial Biology.: [image: http:--www.plosone.org-images-pone_120x3] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Chen H, Beasley A, Hu Y, Chen X Abstract Mammalian esophagus exhibits a remarkable change in epithelial structure during the transition from embryo to adult. However, the molecular mechanisms of esophageal epithelial development are not well understood. Zebrafish (Danio rerio), a common model organism for vertebrate development and gene function, has not previously been characterized as a model system for eso... περισσότερα »
Phage display peptide libraries in molecular allergology: from epitope mapping to mimotope based immunotherapy
Abstract Identification of allergen epitopes is a key component in proper understanding of the pathogenesis of type I allergies, for understanding cross-reactivity and for development of mimotope immunotherapeutics. Phage particles have garnered recognition in the field of molecular allergology due to their value not only in competitive immunoscreening of peptide libraries but also as immunogenic carriers of allergen mimotopes. They integrate epitope discovery technology and immunization functions into a single platform. This article provides an overview of allergen mimotopes iden... περισσότερα »
Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease
[image: cover.gif?v=1&s=7ed1ee29e575b52989bb5c85] Abstract Upon antigen-specific or allogeneic activation, T cells sharply increase their metabolic activity to cope with augmented needs for proliferation and effector functions. Therefore, enzymes involved in energy metabolism constitute attractive targets to modulate the activity of pathogenic effector T cells in the setting of graft-versus-host-disease (GVHD). Here we show that T cells deficient for acetyl-CoA carboxylase 1 (TACC1) are dramatically less pathogenic than wild type T cells in a lethal C57BL/6 into BALB/c model of a... περισσότερα »
Post-arrest stalling rather than crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro
Although CD8+ T cells have been implied in the pathogenesis of multiple sclerosis (MS), the molecular mechanisms mediating CD8+ T-cell migration across the blood-brain barrier (BBB) into the central nervous system (CNS) are ill defined. Using in vitro live cell imaging, we directly compared the multi-step extravasation of activated CD4+ and CD8+ T cells across primary mouse brain microvascular endothelial cells (pMBMECs) as a model for the BBB under physiological flow. Significantly higher numbers of CD8+ than CD4+ T cells arrested on pMBMECs under non-inflammatory and inflammator... περισσότερα »
Selective depletion of CD11c+CD11b+ dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE
Intravenous (i.v.) injection of a soluble myelin antigen can induce tolerance, which effectively ameliorates experimental autoimmune encephalomyelitis (EAE). We have previously shown that i.v. MOG induces tolerance in EAE and expands a subpopulation of tolerogenic CD11c+CD11b+ dendritic cells (DCs) with an immature phenotype having low expression of IA and co-stimulatory molecules CD40, CD86, and CD80. Here we further investigate the role of tolerogenic DCs in i.v. tolerance by injecting clodronate-loaded liposomes, which selectively deplete CD11c+CD11b+ and immature DCs, but not... περισσότερα »
SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
[image: cover.gif?v=1&s=7ed1ee29e575b52989bb5c85] Invariant Natural Killer T (iNKT) cells differentiate in the thymus into three distinct lineages defined by their cytokine and transcription factor expression. SLAM-associated protein (SAP) is essential for early stages of iNKT cell development, but its role during terminal differentiation of iNKT1, iNKT2 or iNKT17 cells remains unclear. Taking advantage of SAP-deficient mice expressing a Vα14-Jα18 TCRα transgene, we found that SAP is critical not only for IL-4 production but also for the terminal differentiation of IL-4-producing ... περισσότερα »
Feasibility and Utility of Chest-X ray on Portable Normothermic Perfusion System.
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/28ULJlX
Safeguarding Fertility With Whole Ovary Cryopreservation and Microvascular Transplantation: Higher Follicular Survival With Vitrification Than With Slow Freezing in a Ewe Model.
Background: In young women, ovarian cortex cryopreservation before gonadotoxic chemotherapy and its avascular grafting after cancer healing permitted fertility restoration. However, ischemia reduced the grafts' lifespan. Microvascular transplantation of cryopreserved whole ovary may allow immediate revascularization, ensuring better fertility preservation, but the best cryopreservation method is unknown. We aimed to compare slow freezing and vitrification of whole ovary for fertility preservation purposes, in an ewe model. Methods: Twelve ewes were allocated at random to slow freezi... περισσότερα »
Association of Pretransplant Skin Cancer With Posttransplant Malignancy, Graft Failure and Death in Kidney Transplant Recipients.
Background: Posttransplant malignancy (PTM) is one of the leading causes of late death in kidney recipients. Those with a cancer history may be more prone to develop a recurrent or a new cancer. We studied the association between pretransplant skin cancer, PTM, death, and graft failure. Methods: Primary adult kidney recipients transplanted between 2005 and 2013 were included. Malignancy information was obtained from Organ Procurement Kidney Transplant Network/United Network for Organ Sharing registration and follow-up forms. Posttransplant malignancy was classified into skin cancer, ... περισσότερα »
Long-Term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients.
Background: Limited data are available regarding the long-term metabolic outcomes of functioning pancreas transplants in patients with type 2 diabetes mellitus (T2DM). Methods: To compare the long-term effects of pancreas transplantation in terms of insulin resistance and [beta] cell function, comparison of metabolic variables was performed between type 1 diabetes mellitus (T1DM) and T2DM patients from 1-month posttransplant to 5 years using generalized, linear-mixed models for repeated measures. Results: Among 217 consecutive patients who underwent pancreas transplantation at our c... περισσότερα »
Fibrous Dysplasia of the Temporal Bone
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
with External Auditory Canal Stenosis and Secondary Cholesteatoma Yu-Hsi Liu 1 , Kuo-Ping Chang 1 1 Department of Otorhinolaryngology – Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, Thaiwan, Province of China J Int Adv Otol 2016; 12: 125-128DOI: 10.5152/iao.2016.1381 Abstract Fibrous dysplasia is a slowly progressive benign fibro-osseous disease, rarely occurring in temporal bones. […]
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when […]
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when […]
Syringocystadenomapapilliferum Arising from the External Auditory Canal
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
: A Rare Tumor in a Rare Site Hazem M. Abdel Tawab 1 , Khalid F. Amish 2 , Ibrahim A. Sulaiman 3 , Rubyath C. Rajib 3 1 Department of Otorhinolaryngology, Cairo University School of Medicine, Cairo, Egypt; Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman 2 Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman. 3 Department of Pathology, […]
Anterior Displacement of the Geniculate Ganglion
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Tomoyasu Tachibana 1 , Yorihisa Orita 2 , Kazunori Nishizaki 2 1 Clinic of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan 2 Department of Otolaryngology, Okayama University School of Medicine, Okayama, Japan J Int Adv Otol 2016; 12: 113-115DOI: 10.5152/iao.2016.1559 Abstract We present the case of a 34-year-old Japanese woman with cholesteatoma of the middle ear. During the […]
Cochlear Implantation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Alternative Techniques in Özgür Sürmelioğlu 1 , Süleyman Özdemir 1 , Özgür Tarkan 1 , Ülkü Tuncer 1 , Fikret Çetik 1 , Karahan Kara 1 , Mete Kıroğlu 1 J Int Adv Otol 2016; 12: 109-112DOI: 10.5152/iao.2015.1022 Abstract OBJECTIVE: To review the alternative techniques in cochlear implantation and to compare the complications with different techniques. MATERIALS and METHODS: Patients who had […]
Eustachian Tube Dysfunction Questionnaire
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Responsiveness of the 7-item Shari Van Roeyen 1 , Paul Van de Heyning 1 , Vincent Van Rompaey 1 1 Antwerp University Hospital, Otorhinolaryngology and Head and Neck Surgery, Edegem, Belgium; University of Antwerp, School of Medicine and Health Sciences, Wilrijk, Belgium J Int Adv Otol 2016; 12: 106-108DOI: 10.5152/iao.2016.2086 Abstract OBJECTIVE: Baro-challenge-induced Eustachian tube (ET) dysfunction is […]
Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
The Role of Mehmet Taylan Güçlütürk 1 , Zeynep Nil Ünal 2 , Onur İsmi 1 , Mehmet Burak Yavuz Çimen 3 , Murat Ünal 1 1 Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey 2 Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey 3 Department of Medical Biochemistry, Mersin University School of Medicine, Mersin, Turkey […]
Asymmetrical Audiovestibular Symptoms
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
The Agreement between Protocols for the Investigation of Robert Nash 1 , Anooj Majithia 1 , Arvind Singh 1 1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, London, United Kingdom J Int Adv Otol 2016; 12: 98-100DOI: 10.5152/iao.2016.1581 Abstract OBJECTIVE: There are a number of published criteria for the investigation of asymmetrical audiovestibular symptoms. Our […]
Vertigo Spells
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Response Over Time of Vertigo Spells to Intratympanic Dexamethasone Treatment in Meniere’s Disease Patients Nabil Atrache Al Attrache 1 , Claudio Krstulovic 1 , Vanesa Pérez Guillen 1 , Constantino Morera Pérez 1 , Herminio Pérez Garrigues 1 J Int Adv Otol 2016; 12: 92-97DOI: 10.5152/iao.2016.2177 Abstract OBJECTIVE: To assess the effectiveness and response over time of intratympanic dexamethasone on […]
Asymmetrical Audiovestibular Symptoms
The Agreement between Protocols for the Investigation of Robert Nash 1 , Anooj Majithia 1 , Arvind Singh 1 1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, London, United Kingdom J Int Adv Otol 2016; 12: 98-100 DOI: 10.5152/iao.2016.1581 Abstract *OBJECTIVE*: There are a number of published criteria for the investigation of asymmetrical audiovestibular symptoms. Our aim was to determine the agreement between these protocols when determining whether to investigate a group of patients treated at our institution. * MATERIALS and METHODS*: Retr... περισσότερα »
Increased Velocity Storage in Subjects with Meniere’s Disease
Claudio Krstulovic 1 , Nabil Atrache Al Attrache 1 , Herminio Pérez Garrigues 2 , Herminia Argente-Escrig 3 , Luis Bataller Alberola 3 , Constantino Morera Pérez 2 1 Department of Otolaryngology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 2 Department of Otolaryngology, Hospital Universitario La Fe, Valencia, Spain. 3 Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, Spain J Int Adv Otol 2016; 12: 87-91 DOI: 10.5152/iao.2016.1947 Abstract *OBJECTIVE*: Velocity storage mechanism is a multisensory rotation estimator; it... περισσότερα »
Vertigo Spells
Response Over Time of Vertigo Spells to Intratympanic Dexamethasone Treatment in Meniere's Disease Patients Nabil Atrache Al Attrache 1 , Claudio Krstulovic 1 , Vanesa Pérez Guillen 1 , Constantino Morera Pérez 1 , Herminio Pérez Garrigues 1 J Int Adv Otol 2016; 12: 92-97 DOI: 10.5152/iao.2016.2177 Abstract *OBJECTIVE*: To assess the effectiveness and response over time of intratympanic dexamethasone on the symptoms of Meniere's disease. * MATERIALS and METHODS*: We performed a matched cohort study of 24 patients with Meniere's disease who were unresponsive to initial tre... περισσότερα »
Wideband Tympanometry Normative Data for Different Age Groups
in Turkish Population Abdulkadir Özgür 1 , Banu Müjdeci 2 , Suat Terzi 1 , Zerrin Özergin Coşkun 1 , Enes Yiğit 1 , Engin Dursun 1 1 Department of Otorhinolaryngology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey 2 Department of Audiology, Yıldırım Beyazıt University Institute of Health Sciences, Ankara, Turkey J Int Adv Otol 2016; 12: 82-86 DOI: 10.5152/iao.2015.1408 Abstract *OBJECTIVE*: Studies on the use of wideband tympanometry (WBT) for the evaluation of middle ear pathologies have been increasing gradually in recent years. However, studies... περισσότερα »
Severe Chronic Tinnitus : Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms
in Turkish Patients with Severe Chronic Tinnitus Salim Yüce 1 , Enver Sancakdar 2 , Gökhan Bağcı 3 , Sema Koç 4 , Hande Küçük Kurtulgan 3 , Binnur Bağcı 5 , Mansur Doğan 1 , İsmail Önder Uysal 1 1 Department of Otorhinolaryngology, Cumhuriyet University School of Medicine, Sivas, Turkey. 2 Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey 3 Department of Medical Genetics, Cumhuriyet University School of Medicine, Sivas, Turkey 4 Department of Ear Nose Throat Head and Neck Surgery, Antalya Training and Research Hospital, Antalya,... περισσότερα »
Tinnitus Retraining Therapy
in Unilateral Tinnitus Patients with Single Side Deafness Sang Hoon Kim 1 , Jae Yong Byun 1 , Seung Geun Yeo 1 , Moon Suh Park 1 1 Department of Otorhinolaryngology, Kyung Hee University Graduate School, Seoul, Korea J Int Adv Otol 2016; 12: 72-76 DOI: 10.5152/iao.2016.1949 Abstract *OBJECTIVE*: The purpose of this study was to evaluate the audiologic and clinical characteristics of the tinnitus in single-sided deafness (SSD) patients and to determine whether tinnitus retraining therapy (TRT) is beneficial to those patients who suffer from tinnitus with SSD. *MATERIALS... περισσότερα »
Smartphone Based Audiometric Test
for Confirming the Level of Hearing; Is It Useable in Underserved Areas? Levent Renda 1 , Ömer Tarık Selçuk 1 , Hülya Eyigör 1 , Üstün Osma 1 , Mustafa Deniz Yılmaz 1 1 Department of Ear Nose and Throat, Antalya Training and Research Hospital, Antalya, Turkey J Int Adv Otol 2016; 12: 61-66 DOI: 10.5152/iao.2016.1421 Abstract *OBJECTIVE*: To determine the hearing levels of participants of a randomized group using a smartphone hearing application and to compare these results with the results from a pure-tone audiogram. * MATERIALS and METHODS*: A heterogenous group cons... περισσότερα »
Intensity on the Speech Evoked Auditory Late Latency Response
The Effect of Intensity on the Speech Evoked Auditory Late Latency Response in Normal Hearing Individuals Hari Prakash 1 , Aju Abraham 1 , Bellur Rajashekar 1 , Krishna Yerraguntla 1 1 Department of Speech and Hearing, School of Allied Health Science, Karnataka, India J Int Adv Otol 2016; 12: 67-71 DOI: 10.5152/iao.2016.1776 Abstract *OBJECTIVE*: Among the stimulus factors, the influence of presentation level is less studied in normal-hearing individuals when using speech stimuli withvarious presentation levels for the auditory late latency response (ALLR). Hence, the pre... περισσότερα »
Hearing Loss in Persons Exposed and not Exposed to Occupational Noise
Martina Kovalova 1 , Eva Mrazkova 1 , Petra Sachova 2 , Kristyna Vojkovska 3 , Hana Tomaskova 1 , Jana Janoutova 1 , Vladimir Janout 1 1 Department of Epidemiology and Public Health, University of Ostrava Faculty of Medicine, Ostrava, Czech Republic 2 Department of Preventive Medicine, Palacký University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Czech Republic 3 Center for Hearing and Balance Disorders, Ostrava, Czech Republic J Int Adv Otol 2016; 12: 49-54 DOI: 10.5152/iao.2016.1770 Abstract *OBJECTIVE*: This study aimed to compare hearing loss in indi... περισσότερα »
Hearing Screening
Follow-Up Results of Newborns after Hearing Screening at a Training and Research Hospital in Turkey Rasim Yılmazer 1 , Mine Zahide Yazıcı 2 , İbrahim Erdim 2 , Hakan Kamil Kaya 2 , Şengül Özcan Dalbudak 2 , Tülin Fatma Kayhan 2 1 Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Otolaryngology-Head and Neck Surgery, İstanbul Medipol University, İstanbul, Turkey 2 Department of Otorhinolaryngology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey J Int Adv Otol 2016; ... περισσότερα »
Differentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells into Auditory Hair Cells and Neurons
In Vitro Kicheol Kil 1 , Mi Young Choi 2 , Kyoung Ho Park 2 1 Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea 2 Department of Otolaryngology, The Catholic University of Korea, Seoul, Republic of Korea J Int Adv Otol 2016; 12: 37-42 DOI: 10.5152/iao.2016.1190 Abstract OBJECTIVE: We attempted to induce mesenchymal stem cells (MSCs) from human Wharton's jelly (WJ) to differentiate into neuronal progenitor cells, neurons, and auditory hair cells. MATERIALS and METHODS: MSCs were isolated from WJ from human umbilical cords and cul... περισσότερα »
Radiological Imaging Findings of Patients with Congenital Totally Hearing Loss
Muhammed Dağkıran 1 , Nermin Dağkıran 2 , Özgür Sürmelioğlu 1 , Tuğsan Ballı 2 , Ülkü Tuncer 1 , Erol Akgül 2 , Fikret Çetik 1 1 Department of Otorhinolaryngology, Çukurova University School of Medicine, Adana, Turkey 2 Department of Radiology, Çukurova University School of Medicine, Adana, Turkey J Int Adv Otol 2016; 12: 43-48 DOI: 10.5152/iao.2015.1450 Abstract OBJECTIVE: The aim of this study was to determine and classify inner ear abnormalities in patients who had cochlear implants because of congenital sensorineural hearing loss using preoperative temporal bone co... περισσότερα »
Acoustic Rhinometry and Rhinomanometry in Tympanoplasty Surgery
Prognostic Value of Kazım Tekin 1 , Medine Kara 2 , Oğuz Güçlü 2 , Halil Erdoğan 2 , Fevzi Sefa Dereköy 2 1 Department of Otorhinolaryngology, Boğazlıyan State Hospital, Yozgat, Turkey 2 Department of Otorhinolaryngology, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey J Int Adv Otol 2016; 12: 32-36 DOI: 10.5152/iao.2016.1398 Abstract OBJECTIVE: Chronic otitis media (COM) is a disorder characterized by perforation of the eardrum and hearing loss following chronic inflammation of the middle ear cavity, ossicules, and mastoid cells. Eustachian dysfunc... περισσότερα »
Endoscopic and Microscopic Approach Type 1 Tympanoplasty for Simple Chronic Otitis Media
A Comparative Study of Tzu-Yen Huang 1 , Kuen-Yao Ho 2 , Ling Feng Wang 2 , Chen-Yu Chien 2 , Hsun-Mo Wang 3 1 Department of Otolaryngology, Kaohsiung Medical University Hospital, Taiwan. 2 Department of Otolaryngology, Kaohsiung Medical University Hospital, Taiwan; Department of Otolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan. 3 Department of Otolaryngology, Kaohsiung Medical University Hospital, Taiwan; Department of Otolaryngology, Kaohsiung Municipal Ta-Tung Hospital, Taiwan J Int Adv Otol 2016; 12: 28-31 DOI: 10.5152/iao.2... περισσότερα »
Percutaneous Bone-Anchored Hearing Aid Abutment Systems
Two Different Percutaneous Bone-Anchored Hearing Aid Abutment Systems: Comparative Clinical Study Beldan Polat 1 , Mete İşeri 2 , Kadir Serkan Orhan 1 , Ayça Başkadem Yılmazer 3 , Necati Enver 1 , Didem Ceylan 1 , Ahmet Kara 2 , Yahya Güldiken 1 , Şenol Çomoğlu 1 1 Department of Otorhinolaryngology Head and Neck Surgery, İstanbul University School of Medicine, İstanbul, Turkey 2 Department of Otorhinolaryngology Head and Neck Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey 3 Clinic of Otorhinolaryngology Head and Neck Surgery, Okmeydanı Training an... περισσότερα »
Bimodal Stimulation with Cochlear Implant and Hearing Aid in Cases of Highly Asymmetrical Hearing Loss
Ignacio Sanhueza 1 , Raquel Manrique 2 , Alicia Huarte 2 , Iñigo Ruiz de Erenchun 1 , Manuel Manrique 2 1 Department of Otorhinolaryngology, Complejo Hospitalario de Navarra, Pamplona/Navarre, Spain 2 Department of Otorhinolaryngology, Clinica Universidad de Navarra, Pamplona/Navarre, Spain J Int Adv Otol 2016; 12: 16-22 DOI: 10.5152/iao.2016.2185 Abstract OBJECTIVE: Bimodal stimulation is a possible treatment for asymmetrical hearing loss, wherein 1 ear is stimulated with a cochlear implant and the other is stimulated with a hearing aid. This emerging indication has gaine... περισσότερα »
Cochlear Implant Evaluation: Prognosis Estimation by Data Mining System
Gloria Guerra-Jiménez 1 , Ángel Ramos De Miguel 1 , Juan Carlos Falcón González 1 , Silvia Andrea Borkoski Barreiro 1 , Daniel Pérez Plasencia 1 , Ángel Ramos Macías 1 1 Department of Ear Nose Throat, Complejo Hospitalario Insular Materno Infantil, Las Palmas de GC, Spain J Int Adv Otol 2016; 12: 1-7 DOI: 10.5152/iao.2016.510 Abstract *OBJECTIVE*: Prediction of speech recognition (SR) and quality of life (QoL) outcomes after cochlear implantation is one of the most important challenges for otologists. By sifting through very large amounts of data, data mining reveals tr... περισσότερα »
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when […]
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when […]
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Summary Objective To determine the bioequivalence of brivaracetam oral tablet formulations (10, 75, and 100 mg) versus 50 mg oral tablet and to compare the bioavailability of brivaracetam 100 mg intravenous (i.v.) bolus versus 50 and 100 mg tablets, in healthy participants. Methods Phase 1, randomized, open-label, five-period crossover study. Participants received five single doses […]
Plasma taurine levels are not affected by vigabatrin in pediatric patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Summary Vigabatrin is a highly effective antiseizure medication, but its use is limited due to concerns about retinal toxicity. One proposed mechanism for this toxicity is vigabatrin-mediated reduction of taurine. Herein we assess plasma taurine levels in a retrospective cohort of children with epilepsy, including a subset receiving vigabatrin. All children who underwent a plasma […]
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Summary Objective To determine the bioequivalence of brivaracetam oral tablet formulations (10, 75, and 100 mg) versus 50 mg oral tablet and to compare the bioavailability of brivaracetam 100 mg intravenous (i.v.) bolus versus 50 and 100 mg tablets, in healthy participants. Methods Phase 1, randomized, open-label, five-period crossover study. Participants received five single doses […]
Plasma taurine levels are not affected by vigabatrin in pediatric patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Summary Vigabatrin is a highly effective antiseizure medication, but its use is limited due to concerns about retinal toxicity. One proposed mechanism for this toxicity is vigabatrin-mediated reduction of taurine. Herein we assess plasma taurine levels in a retrospective cohort of children with epilepsy, including a subset receiving vigabatrin. All children who underwent a plasma […]
Traumatic asphyxia
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Traumatic asphyxia: a medical emergency hat result in the loss of the ability to breathe brought on by intense compression of the chest. This leads to back-flow of blood from the right side of the heart into the veins of the neck and brain. Traumatic asphyxia is also known as Perte’s syndrome. Symptoms and signs […]
Subjective health complaints predict functional outcome six months after stroke
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Objectives Cerebrovascular stroke is a main cause of lasting disability in older age, and initial stroke severity has been established as a main determinant for the degree of functional loss. In this study, we searched for other predictors of functional outcome in a cohort of stroke patients participating in an early supported discharge randomised controlled […]
Subjective health complaints predict functional outcome six months after stroke
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Objectives Cerebrovascular stroke is a main cause of lasting disability in older age, and initial stroke severity has been established as a main determinant for the degree of functional loss. In this study, we searched for other predictors of functional outcome in a cohort of stroke patients participating in an early supported discharge randomised controlled […]
CRISPR-Cas9 technology: applications and human disease modelling
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Genome engineering is a powerful tool for a wide range of applications in biomedical research and medicine. The development of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system has revolutionized the field of gene editing, thus facilitating efficient genome editing through the creation of targeted double-strand breaks of almost any organism and cell type. […]
Performance of Cochlear Implants in Pediatric Patients with Auditory Neuropathy Spectrum Disorder
Guilherme Machado de Carvalho 1 , Priscila Ramos 2 , Castilho Arthur 1 , Alexandre Guimarães 1 , Edi Sartorato 2 1 Department of Ear Nose Throat Head and Neck Surgery, UNICAMP (Campinas University, São Paulo, Brazil), Campinas, Brazil 2 Centro de Biologia Molecular e Engenharia Genética, UNICAMP (Campinas University, São Paulo, Brazil), Campinas, Brazil J Int Adv Otol 2016; 12: 8-15 DOI: 10.5152/iao.2016.2232 Abstract OBJECTIVE: To describe the performance and results of CIs (cochlear implant) in patients with AN (auditory neuropathy) and to present a medical literature r... περισσότερα »
Inhaled Anesthetics & Ventilator-Induced Lung Injury
Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury: BACKGROUND: Mechanical ventilation is an important perioperative tool in anesthesia and a lifesaving treatment for respiratory failure, but it can lead to ventilator-associated lung injury. Inhaled anesthetics have demonstrated protective properties in various models of organ damage. We compared the lung-protective potential of inhaled sevoflurane, isoflurane, and desflurane in a mouse model of ventilator-induced lung injury (VILI). METHODS: C57BL/6N mice were randomized i... περισσότερα »
Anterior Displacement of the Geniculate Ganglion
Tomoyasu Tachibana 1 , Yorihisa Orita 2 , Kazunori Nishizaki 2 1 Clinic of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan 2 Department of Otolaryngology, Okayama University School of Medicine, Okayama, Japan J Int Adv Otol 2016; 12: 113-115 DOI: 10.5152/iao.2016.1559 Abstract We present the case of a 34-year-old Japanese woman with cholesteatoma of the… Continue reading Anterior Displacement of the Geniculate Ganglion
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when… Continue reading Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when… Continue reading Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when… Continue reading Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
Syringocystadenomapapilliferum Arising from the External Auditory Canal
: A Rare Tumor in a Rare Site Hazem M. Abdel Tawab 1 , Khalid F. Amish 2 , Ibrahim A. Sulaiman 3 , Rubyath C. Rajib 3 1 Department of Otorhinolaryngology, Cairo University School of Medicine, Cairo, Egypt; Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman 2 Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah,… Continue reading Syringocystadenomapapilliferum Arising from the External Auditory Canal
Cochlear Implantation
Alternative Techniques in Özgür Sürmelioğlu 1 , Süleyman Özdemir 1 , Özgür Tarkan 1 , Ülkü Tuncer 1 , Fikret Çetik 1 , Karahan Kara 1 , Mete Kıroğlu 1 J Int Adv Otol 2016; 12: 109-112 DOI: 10.5152/iao.2015.1022 Abstract OBJECTIVE: To review the alternative techniques in cochlear implantation and to compare the complications with… Continue reading Cochlear Implantation
Eustachian Tube Dysfunction Questionnaire
Responsiveness of the 7-item Shari Van Roeyen 1 , Paul Van de Heyning 1 , Vincent Van Rompaey 1 1 Antwerp University Hospital, Otorhinolaryngology and Head and Neck Surgery, Edegem, Belgium; University of Antwerp, School of Medicine and Health Sciences, Wilrijk, Belgium J Int Adv Otol 2016; 12: 106-108 DOI: 10.5152/iao.2016.2086 Abstract OBJECTIVE: Baro-challenge-induced Eustachian… Continue reading Eustachian Tube Dysfunction Questionnaire
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when… Continue reading Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo
The Role of Mehmet Taylan Güçlütürk 1 , Zeynep Nil Ünal 2 , Onur İsmi 1 , Mehmet Burak Yavuz Çimen 3 , Murat Ünal 1 1 Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey 2 Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey 3 Department of Medical Biochemistry, Mersin University… Continue reading Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo
Asymmetrical Audiovestibular Symptoms
The Agreement between Protocols for the Investigation of Robert Nash 1 , Anooj Majithia 1 , Arvind Singh 1 1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, London, United Kingdom J Int Adv Otol 2016; 12: 98-100 DOI: 10.5152/iao.2016.1581 Abstract OBJECTIVE: There are a number of published criteria for the investigation of… Continue reading Asymmetrical Audiovestibular Symptoms
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. from #Audiology via xlomafota13 on Inoreader http://ift.tt/297xR5r via IFTTT
Syringocystadenomapapilliferum Arising from the External Auditory Canal
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
: A Rare Tumor in a Rare Site Hazem M. Abdel Tawab 1 , Khalid F. Amish 2 , Ibrahim A. Sulaiman 3 , Rubyath C. Rajib 3 1 Department of Otorhinolaryngology, Cairo University School of Medicine, Cairo, Egypt; Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman 2 Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, […]
Anterior Displacement of the Geniculate Ganglion
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Tomoyasu Tachibana 1 , Yorihisa Orita 2 , Kazunori Nishizaki 2 1 Clinic of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan 2 Department of Otolaryngology, Okayama University School of Medicine, Okayama, Japan J Int Adv Otol 2016; 12: 113-115 DOI: 10.5152/iao.2016.1559 Abstract We present the case of a 34-year-old Japanese woman with cholesteatoma of the […]
Cochlear Implantation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Alternative Techniques in Özgür Sürmelioğlu 1 , Süleyman Özdemir 1 , Özgür Tarkan 1 , Ülkü Tuncer 1 , Fikret Çetik 1 , Karahan Kara 1 , Mete Kıroğlu 1 J Int Adv Otol 2016; 12: 109-112 DOI: 10.5152/iao.2015.1022 Abstract OBJECTIVE: To review the alternative techniques in cochlear implantation and to compare the complications with […]
Eustachian Tube Dysfunction Questionnaire
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Responsiveness of the 7-item Shari Van Roeyen 1 , Paul Van de Heyning 1 , Vincent Van Rompaey 1 1 Antwerp University Hospital, Otorhinolaryngology and Head and Neck Surgery, Edegem, Belgium; University of Antwerp, School of Medicine and Health Sciences, Wilrijk, Belgium J Int Adv Otol 2016; 12: 106-108 DOI: 10.5152/iao.2016.2086 Abstract OBJECTIVE: Baro-challenge-induced Eustachian […]
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when […]
Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
The Role of Mehmet Taylan Güçlütürk 1 , Zeynep Nil Ünal 2 , Onur İsmi 1 , Mehmet Burak Yavuz Çimen 3 , Murat Ünal 1 1 Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey 2 Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey 3 Department of Medical Biochemistry, Mersin University […]
Asymmetrical Audiovestibular Symptoms
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
The Agreement between Protocols for the Investigation of Robert Nash 1 , Anooj Majithia 1 , Arvind Singh 1 1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, London, United Kingdom J Int Adv Otol 2016; 12: 98-100 DOI: 10.5152/iao.2016.1581 Abstract OBJECTIVE: There are a number of published criteria for the investigation of […]
Vertigo Spells
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Response Over Time of Vertigo Spells to Intratympanic Dexamethasone Treatment in Meniere’s Disease Patients Nabil Atrache Al Attrache 1 , Claudio Krstulovic 1 , Vanesa Pérez Guillen 1 , Constantino Morera Pérez 1 , Herminio Pérez Garrigues 1 J Int Adv Otol 2016; 12: 92-97 DOI: 10.5152/iao.2016.2177 Abstract OBJECTIVE: To assess the effectiveness and response […]
Increased Velocity Storage in Subjects with Meniere’s Disease
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Claudio Krstulovic 1 , Nabil Atrache Al Attrache 1 , Herminio Pérez Garrigues 2 , Herminia Argente-Escrig 3 , Luis Bataller Alberola 3 , Constantino Morera Pérez 2 1 Department of Otolaryngology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 2 Department of Otolaryngology, Hospital Universitario La Fe, Valencia, Spain. 3 Department of Neurology, Hospital […]
Endoxifen, a New Treatment Option for Mania: A Double-Blind, Active-Controlled Trial Demonstrates the Antimanic Efficacy of Endoxifen
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
The protein kinase C (PKC) signaling system plays a role in mood disorders and PKC inhibitors such as endoxifen may be an innovative medicine for bipolar disorder (BP) patients. In this study we show for the first time the antimanic properties of endoxifen in patients with bipolar I disorder (BPD I) with current manic or […]
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. from #Audiology via xlomafota13 on Inoreader http://ift.tt/297xR5r via IFTTT
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. from #Audiology via ola Kala on Inoreader http://ift.tt/297xR5r via IFTTT
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. from #Audiology via ola Kala on Inoreader http://ift.tt/297xR5r via IFTTT
Eustachian Tube Dysfunction Questionnaire
Responsiveness of the 7-item Shari Van Roeyen 1 , Paul Van de Heyning 1 , Vincent Van Rompaey 1 1 Antwerp University Hospital, Otorhinolaryngology and Head and Neck Surgery, Edegem, Belgium; University of Antwerp, School of Medicine and Health Sciences, Wilrijk, Belgium J Int Adv Otol 2016; 12: 106-108 DOI: 10.5152/iao.2016.2086 Abstract *OBJECTIVE*: Baro-challenge-induced Eustachian tube (ET) dysfunction is defined as the presence of aural discomfort, popping, or pain, which only arises in case of ambient pressure changes, without abnormalities on otoscopy or tympanometry. ... περισσότερα »
Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo
The Role of Mehmet Taylan Güçlütürk 1 , Zeynep Nil Ünal 2 , Onur İsmi 1 , Mehmet Burak Yavuz Çimen 3 , Murat Ünal 1 1 Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey 2 Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey 3 Department of Medical Biochemistry, Mersin University School of Medicine, Mersin, Turkey J Int Adv Otol 2016; 12: 101-105 DOI: 10.5152/iao.2015.1412 Abstract *OBJECTIVE*: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as... περισσότερα »
Asymmetrical Audiovestibular Symptoms
The Agreement between Protocols for the Investigation of Robert Nash 1 , Anooj Majithia 1 , Arvind Singh 1 1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, London, United Kingdom J Int Adv Otol 2016; 12: 98-100 DOI: 10.5152/iao.2016.1581 Abstract *OBJECTIVE*: There are a number of published criteria for the investigation of asymmetrical audiovestibular symptoms. Our aim was to determine the agreement between these protocols when determining whether to investigate a group of patients treated at our institution. *MATERIALS and METHODS*: Retrospec... περισσότερα »
Vertigo Spells
Response Over Time of Vertigo Spells to Intratympanic Dexamethasone Treatment in Meniere’s Disease Patients Nabil Atrache Al Attrache 1 , Claudio Krstulovic 1 , Vanesa Pérez Guillen 1 , Constantino Morera Pérez 1 , Herminio Pérez Garrigues 1 J Int Adv Otol 2016; 12: 92-97 DOI: 10.5152/iao.2016.2177 Abstract *OBJECTIVE*: To assess the effectiveness and response over time of intratympanic dexamethasone on the symptoms of Meniere’s disease. *MATERIALS and METHODS*: We performed a matched cohort study of 24 patients with Meniere’s disease who were unresponsive to initial treatme... περισσότερα »
Increased Velocity Storage in Subjects with Meniere’s Disease
Claudio Krstulovic 1 , Nabil Atrache Al Attrache 1 , Herminio Pérez Garrigues 2 , Herminia Argente-Escrig 3 , Luis Bataller Alberola 3 , Constantino Morera Pérez 2 1 Department of Otolaryngology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 2 Department of Otolaryngology, Hospital Universitario La Fe, Valencia, Spain. 3 Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, Spain J Int Adv Otol 2016; 12: 87-91 DOI: 10.5152/iao.2016.1947 Abstract *OBJECTIVE*: Velocity storage mechanism is a multisensory rotation estimator; it c... περισσότερα »
Wideband Tympanometry Normative Data for Different Age Groups
in Turkish Population Abdulkadir Özgür 1 , Banu Müjdeci 2 , Suat Terzi 1 , Zerrin Özergin Coşkun 1 , Enes Yiğit 1 , Engin Dursun 1 1 Department of Otorhinolaryngology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey 2 Department of Audiology, Yıldırım Beyazıt University Institute of Health Sciences, Ankara, Turkey J Int Adv Otol 2016; 12: 82-86 DOI: 10.5152/iao.2015.1408 Abstract *OBJECTIVE*: Studies on the use of wideband tympanometry (WBT) for the evaluation of middle ear pathologies have been increasing gradually in recent years. However, studies r... περισσότερα »
Severe Chronic Tinnitus : Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms
in Turkish Patients with Severe Chronic Tinnitus Salim Yüce 1 , Enver Sancakdar 2 , Gökhan Bağcı 3 , Sema Koç 4 , Hande Küçük Kurtulgan 3 , Binnur Bağcı 5 , Mansur Doğan 1 , İsmail Önder Uysal 1 1 Department of Otorhinolaryngology, Cumhuriyet University School of Medicine, Sivas, Turkey. 2 Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey 3 Department of Medical Genetics, Cumhuriyet University School of Medicine, Sivas, Turkey 4 Department of Ear Nose Throat Head and Neck Surgery, Antalya Training and Research Hospital, Antalya, ... περισσότερα »
Tinnitus Retraining Therapy
in Unilateral Tinnitus Patients with Single Side Deafness Sang Hoon Kim 1 , Jae Yong Byun 1 , Seung Geun Yeo 1 , Moon Suh Park 1 1 Department of Otorhinolaryngology, Kyung Hee University Graduate School, Seoul, Korea J Int Adv Otol 2016; 12: 72-76 DOI: 10.5152/iao.2016.1949 Abstract *OBJECTIVE*: The purpose of this study was to evaluate the audiologic and clinical characteristics of the tinnitus in single-sided deafness (SSD) patients and to determine whether tinnitus retraining therapy (TRT) is beneficial to those patients who suffer from tinnitus with SSD. *MATERIALS and... περισσότερα »
Intensity on the Speech Evoked Auditory Late Latency Response
The Effect of Intensity on the Speech Evoked Auditory Late Latency Response in Normal Hearing Individuals Hari Prakash 1 , Aju Abraham 1 , Bellur Rajashekar 1 , Krishna Yerraguntla 1 1 Department of Speech and Hearing, School of Allied Health Science, Karnataka, India J Int Adv Otol 2016; 12: 67-71 DOI: 10.5152/iao.2016.1776 Abstract *OBJECTIVE*: Among the stimulus factors, the influence of presentation level is less studied in normal-hearing individuals when using speech stimuli withvarious presentation levels for the auditory late latency response (ALLR). Hence, the prese... περισσότερα »
Smartphone Based Audiometric Test
for Confirming the Level of Hearing; Is It Useable in Underserved Areas? Levent Renda 1 , Ömer Tarık Selçuk 1 , Hülya Eyigör 1 , Üstün Osma 1 , Mustafa Deniz Yılmaz 1 1 Department of Ear Nose and Throat, Antalya Training and Research Hospital, Antalya, Turkey J Int Adv Otol 2016; 12: 61-66 DOI: 10.5152/iao.2016.1421 Abstract *OBJECTIVE*: To determine the hearing levels of participants of a randomized group using a smartphone hearing application and to compare these results with the results from a pure-tone audiogram. *MATERIALS and METHODS*: A heterogenous group consistin... περισσότερα »
Hearing Screening
Follow-Up Results of Newborns after Hearing Screening at a Training and Research Hospital in Turkey Rasim Yılmazer 1 , Mine Zahide Yazıcı 2 , İbrahim Erdim 2 , Hakan Kamil Kaya 2 , Şengül Özcan Dalbudak 2 , Tülin Fatma Kayhan 2 1 Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Otolaryngology-Head and Neck Surgery, İstanbul Medipol University, İstanbul, Turkey 2 Department of Otorhinolaryngology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey J Int Adv Otol 2016; 1... περισσότερα »
Hearing Loss in Persons Exposed and not Exposed to Occupational Noise
Martina Kovalova 1 , Eva Mrazkova 1 , Petra Sachova 2 , Kristyna Vojkovska 3 , Hana Tomaskova 1 , Jana Janoutova 1 , Vladimir Janout 1 1 Department of Epidemiology and Public Health, University of Ostrava Faculty of Medicine, Ostrava, Czech Republic 2 Department of Preventive Medicine, Palacký University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Czech Republic 3 Center for Hearing and Balance Disorders, Ostrava, Czech Republic J Int Adv Otol 2016; 12: 49-54 DOI: 10.5152/iao.2016.1770 Abstract *OBJECTIVE*: This study aimed to compare hearing loss in indivi... περισσότερα »
Radiological Imaging Findings of Patients with Congenital Totally Hearing Loss
Muhammed Dağkıran 1 , Nermin Dağkıran 2 , Özgür Sürmelioğlu 1 , Tuğsan Ballı 2 , Ülkü Tuncer 1 , Erol Akgül 2 , Fikret Çetik 1 1 Department of Otorhinolaryngology, Çukurova University School of Medicine, Adana, Turkey 2 Department of Radiology, Çukurova University School of Medicine, Adana, Turkey J Int Adv Otol 2016; 12: 43-48 DOI: 10.5152/iao.2015.1450 Abstract OBJECTIVE: The aim of this study was to determine and classify inner ear abnormalities in patients who had cochlear implants because of congenital sensorineural hearing loss using preoperative temporal bone c... περισσότερα »
Differentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells into Auditory Hair Cells and Neurons
In Vitro Kicheol Kil 1 , Mi Young Choi 2 , Kyoung Ho Park 2 1 Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea 2 Department of Otolaryngology, The Catholic University of Korea, Seoul, Republic of Korea J Int Adv Otol 2016; 12: 37-42 DOI: 10.5152/iao.2016.1190 Abstract OBJECTIVE: We attempted to induce mesenchymal stem cells (MSCs) from human Wharton’s jelly (WJ) to differentiate into neuronal progenitor cells, neurons, and auditory hair cells. MATERIALS and METHODS: MSCs were isolated from WJ from human umbilical cords and cu... περισσότερα »
Acoustic Rhinometry and Rhinomanometry in Tympanoplasty Surgery
Prognostic Value of Kazım Tekin 1 , Medine Kara 2 , Oğuz Güçlü 2 , Halil Erdoğan 2 , Fevzi Sefa Dereköy 2 1 Department of Otorhinolaryngology, Boğazlıyan State Hospital, Yozgat, Turkey 2 Department of Otorhinolaryngology, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey J Int Adv Otol 2016; 12: 32-36 DOI: 10.5152/iao.2016.1398 Abstract OBJECTIVE: Chronic otitis media (COM) is a disorder characterized by perforation of the eardrum and hearing loss following chronic inflammation of the middle ear cavity, ossicules, and mastoid cells. Eustachian dysfun... περισσότερα »
Endoscopic and Microscopic Approach Type 1 Tympanoplasty for Simple Chronic Otitis Media
A Comparative Study of Tzu-Yen Huang 1 , Kuen-Yao Ho 2 , Ling Feng Wang 2 , Chen-Yu Chien 2 , Hsun-Mo Wang 3 1 Department of Otolaryngology, Kaohsiung Medical University Hospital, Taiwan. 2 Department of Otolaryngology, Kaohsiung Medical University Hospital, Taiwan; Department of Otolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan. 3 Department of Otolaryngology, Kaohsiung Medical University Hospital, Taiwan; Department of Otolaryngology, Kaohsiung Municipal Ta-Tung Hospital, Taiwan J Int Adv Otol 2016; 12: 28-31 DOI: 10.5152/iao.... περισσότερα »
Percutaneous Bone-Anchored Hearing Aid Abutment Systems
Two Different Percutaneous Bone-Anchored Hearing Aid Abutment Systems: Comparative Clinical Study Beldan Polat 1 , Mete İşeri 2 , Kadir Serkan Orhan 1 , Ayça Başkadem Yılmazer 3 , Necati Enver 1 , Didem Ceylan 1 , Ahmet Kara 2 , Yahya Güldiken 1 , Şenol Çomoğlu 1 1 Department of Otorhinolaryngology Head and Neck Surgery, İstanbul University School of Medicine, İstanbul, Turkey 2 Department of Otorhinolaryngology Head and Neck Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey 3 Clinic of Otorhinolaryngology Head and Neck Surgery, Okmeydanı Training an... περισσότερα »
Bimodal Stimulation with Cochlear Implant and Hearing Aid in Cases of Highly Asymmetrical Hearing Loss
Ignacio Sanhueza 1 , Raquel Manrique 2 , Alicia Huarte 2 , Iñigo Ruiz de Erenchun 1 , Manuel Manrique 2 1 Department of Otorhinolaryngology, Complejo Hospitalario de Navarra, Pamplona/Navarre, Spain 2 Department of Otorhinolaryngology, Clinica Universidad de Navarra, Pamplona/Navarre, Spain J Int Adv Otol 2016; 12: 16-22 DOI: 10.5152/iao.2016.2185 Abstract OBJECTIVE: Bimodal stimulation is a possible treatment for asymmetrical hearing loss, wherein 1 ear is stimulated with a cochlear implant and the other is stimulated with a hearing aid. This emerging indication has gain... περισσότερα »
Performance of Cochlear Implants in Pediatric Patients with Auditory Neuropathy Spectrum Disorder
Guilherme Machado de Carvalho 1 , Priscila Ramos 2 , Castilho Arthur 1 , Alexandre Guimarães 1 , Edi Sartorato 2 1 Department of Ear Nose Throat Head and Neck Surgery, UNICAMP (Campinas University, São Paulo, Brazil), Campinas, Brazil 2 Centro de Biologia Molecular e Engenharia Genética, UNICAMP (Campinas University, São Paulo, Brazil), Campinas, Brazil J Int Adv Otol 2016; 12: 8-15 DOI: 10.5152/iao.2016.2232 Abstract OBJECTIVE: To describe the performance and results of CIs (cochlear implant) in patients with AN (auditory neuropathy) and to present a medical literature ... περισσότερα »
Cochlear Implant Evaluation: Prognosis Estimation by Data Mining System
Gloria Guerra-Jiménez 1 , Ángel Ramos De Miguel 1 , Juan Carlos Falcón González 1 , Silvia Andrea Borkoski Barreiro 1 , Daniel Pérez Plasencia 1 , Ángel Ramos Macías 1 1 Department of Ear Nose Throat, Complejo Hospitalario Insular Materno Infantil, Las Palmas de GC, Spain J Int Adv Otol 2016; 12: 1-7 DOI: 10.5152/iao.2016.510 Abstract *OBJECTIVE*: Prediction of speech recognition (SR) and quality of life (QoL) outcomes after cochlear implantation is one of the most important challenges for otologists. By sifting through very large amounts of data, data mining reveals tre... περισσότερα »
Cochlear Implantation in a Patient with Kabuki Syndrome.
Cochlear Implantation in a Patient with Kabuki Syndrome.: J Int Adv Otol. 2016 ;12(1):129-131 Authors: Vesseur A, Cillessen E, Mylanus E Abstract Criteria for cochlear implants are expanding and now include children with disabilities in addition to hearing loss, such as those with Kabuki syndrome (KS). This case report describes language outcomes and changes in the quality of life of a female child with KS after cochlear implantation. The subject had a profound progressive sensorineural hearing loss, cognitive impairments, and other disabilities and communicated using vocalized s... περισσότερα »
Impaired bolus clearance in asymptomatic older adults during high-resolution impedance manometry
Impaired bolus clearance in asymptomatic older adults during high-resolution impedance manometry: Abstract Background Dysphagia becomes more common in old age. We performed high-resolution impedance manometry (HRIM) in asymptomatic healthy adults (including an older cohort >80 years) to assess HRIM findings in relation to bolus clearance. Methods Esophageal HRIM was performed in a sitting posture in 45 healthy volunteers (*n* = 30 young control, mean age 37 ± 11 years and *n* = 15 older subjects aged 85 ± 4 years) using a 3.2-mm solid-state catheter (Solar GI system; MMS, Enschede,... περισσότερα »
Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD)
Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) - a systematic review on potential biomarkers for neurodegeneration -: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the loss of physiological atonia of skeletal muscles with abnormal behavior during dream sleep. *RBD may be the initial manifestation of neurodegenerative diseases, particularly of α-synucleinopathies such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).* However, gauging the individual risk of subs... περισσότερα »
Mismatch repair gene expression in gastroesophageal cancers.
[image: http:--www.yaysis.com-aves-Turkgastro-ma] Authors: Dracea A, Angelescu C, Danciulescu M, Ciurea M, Ioana M, Burada F Abstract BACKGROUND/AIMS: Mismatch repair (MMR) genes play a critical role in maintaining genomic stability, and the impairment of MMR machinery is associated with different human cancers, mainly colorectal cancer. The purpose of our study was to analyze gene expression patterns of three MMR genes (MSH2, MHS6, and EXO1) in gastroesophageal cancers, a pathology in which the contribution of DNA repair genes remains essentially unclear. MATERIALS AND METHODS: ... περισσότερα »
Ki-67 in tumor tissue is probably a more reliable marker than serum SCCA and CYFRA 21-1 in predicting the clinical course of ESCC
Correlation between Serum SCCA and CYFRA 2 1-1, Tissue Ki-67, and Clinicopathological Factors in Patients with Esophageal Squamous Cell Carcinoma.: J Med Assoc Thai. 2016 ; Authors: Sunpaweravong S, Puttawibul P, Sunpaweravong P, Nitiruangjaras A, Boonyaphiphat P, Kemapanmanus M Abstract BACKGROUND: Squamous cell carcinoma antigen (SCCA) and CYFRA 21-1 have been reported as useful tumor markers for esophageal squamous cell carcinoma (ESCC), but no information has yet been reported about the relationship between these serum tumor markers and tissue proliferative activity (Ki-67) i... περισσότερα »
OtoRhinoLaryngology
3hOtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on InoreaderImpaired bolus clearance in asymptomatic older adults during high-resolution impedance manometry Abstract Background Dysphagia becomes more common in old age. We performed high-resolution impedance manometry (HRIM) in asymptomatic healthy adults (including an older cohort >80 years) to assess HRIM findings in relation to bolus clearance. Methods Esophageal HRIM was performed in…20hOtoRhinoLaryngologyHuman Foramen Magnum Area and Posterior Cranial Fossa Volume Growth in Relation to Cranial ... περισσότερα »
Thymoma Complicating Myasthenia Gravis
[Postoperative Survival for Patients with Thymoma Complicating Myasthenia Gravis - Preliminary Retrospective Results of the ChART Database].: Zhongguo Fei Ai Za Zhi. 2016 Jul 20;19(7):418-24 Authors: Wang F, Pang L, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Yu Z, Zhou X, Liu Y, Liu Y, Gu Z, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: It is so far not clear that how myasthenia gravis (MG) affected the prognosis of thymoma patients. The aim of this assay is to compare the posto... περισσότερα »
The Masaoka-Koga and The IASLC/ITMIG Proposal for The TNM Staging Systems Based on the Chinese Alliance for Research in Thymomas (ChART)
[Comparison of the Masaoka-Koga and The IASLC/ITMIG Proposal for The TNM Staging Systems Based on the Chinese Alliance for Research in Thymomas (ChART) Retrospective Database].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):425-36 Authors: Liang G, Gu Z, Li Y, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou X, Liu Y, Liu Y, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the... περισσότερα »
Pretreatment Biopsy for Histological Diagnosis and Induction Therapy in Thymic Tumors
[Pretreatment Biopsy for Histological Diagnosis and Induction Therapy in Thymic Tumors].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):437-44 Authors: Yue J, Gu Z, Yu Z, Zhang H, Ma Z, Liu Y, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: The aim of this study is to investigate the value of pretreatment biopsy for histological diagnosis and induction therapies in the management of locally advanced thymic malignancies. METHODS: The clinical pathological data of patients with thymic tumors in the Chinese Alliance for Research in Thymomas (ChART) wh... περισσότερα »
Locally Advanced Thymic Tumors
[Preoperative Induction Therapy for Locally Advanced Thymic Tumors: A Retrospective Analysis Using the ChART Database].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):445-52 Authors: Wei Y, Gu Z, Shen Y, Fu J, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou X, Liu Y, Liu Y, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: To evaluate the role of preoperative induction therapy on prognosis of locally advanced thymic malignancies. METHODS: Between 1994 and 2012, patients received preoperative indu... περισσότερα »
Clinically Early-stage Thymic Malignancies: Video-assisted Thoracoscopic Thymectomy versus Open Approaches
[Perioperative Outcomes and Long-term Survival in Clinically Early-stage Thymic Malignancies: Video-assisted Thoracoscopic Thymectomy versus Open Approaches].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):453-8 Authors: Wang H, Gu Z, Ding J, Tan L, Fu J, Shen Y, Wei Y, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou X, Liu Y, Liu Y, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: Video-assisted thoracoscopic surgery (VATS) theoretically offers advantages over open thymectomy for clinically early-sta... περισσότερα »
Thymectomy versus Tumor Resection for Early-stage Thymic Malignancies
A Chinese Alliance for Research in Thymomas (ChART) Retrospective Database Analysis].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):459-64 Authors: Gu Z, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou X, Liu Y, Liu Y, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: To evaluate the surgical outcomes of tumor resection with or without total thymectomy for thymic epithelial tumors (TETs) using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. MET... περισσότερα »
Postoperative Chemotherapy on Thymomas
[Application of Postoperative Chemotherapy on Thymomas and Its Prognostic Effect].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):473-82 Authors: Ma K, Gu Z, Han Y, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou X, Liu Y, Liu Y, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: To study the role of postoperative chemotherapy and its prognostic effect in Masaoka-Koga stage III and IV thymic tumors. METHODS: Between 1994 and 2012, 1,700 patients with thymic tumors who underwent surg... περισσότερα »
Tumor-specific expression of shVEGF and suicide gene
as a novel strategy for esophageal cancer therapy.: World J Gastroenterol. 2016 Jun ;22(23):5342-52 Authors: Liu T, Wu HJ, Liang Y, Liang XJ, Huang HC, Zhao YZ, Liao QC, Chen YQ, Leng AM, Yuan WJ, Zhang GY, Peng J, Chen YH Abstract AIM: To develop a potent and safe gene therapy for esophageal cancer. METHODS: An expression vector carrying fusion suicide gene (yCDglyTK) and shRNA against vascular endothelial growth factor (VEGF) was constructed and delivered into EC9706 esophageal cancer cells by calcium phosphate nanoparticles (CPNP). To achieve tumor selectivity, expression of th... περισσότερα »
Neuroendocrine neoplasms (NENs) of the esophagus : Esophageal NENs most commonly were neuroendocrine carcinomas, presented in metastatic stage and were associated with poor prognosis. Grade 2 (G2) tumors had better outcomes than NEC (G3). In nonmetastatic disease, presence of lymph node metastasis and unresectable disease had poorer outcomes.
Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience.: J Oncol. 2016;2016:2402417 Authors: Babu Kanakasetty G, Dasappa L, Lakshmaiah KC, Kamath M, Jacob LA, Mallekavu SB, Rajeev LK, Haleshappa RA, Kadabur Nagendrappa L, Saldanha SC, Kumar RV Abstract Purpose. Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide. Studies on clinical profile, management, and outcomes are very uncommon. Methods. We report the largest single institution retrospective review of 43 patien... περισσότερα »
Allergy and Immunology
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates Developing and pilot testing an electronic medical record–based allergen immunotherapy template Yesterday, 26 Ιουνίου 2016, 4:32:47 πμ Decision support and health information technologies, such as electronic medical record (EMR) systems, have been reported to enhance the quality and efficiency of medical care.1,2 EMR systems are increasingly being used by allergy/immunology physicians to facilitate clinical documentation surrounding office visits an... περισσότερα »
Fatal familial insomnia: Mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus
Fatal familial insomnia: Mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus: Abstract The expression of subunits of mitochondrial respiratory complexes and components of the protein synthesis machinery from the nucleolus to the ribosome was analyzed in the mediodorsal thalamus in seven cases of Fatal Familial Insomnia (FFI) compared with age-matched controls. NDUFB8 (complex I subunit), SDHB (complex II subunit), UQCRC2 (complex III subunit), COX2 (complex IV subunit) and ATP50 (complex V subunit) expression levels, as revealed by western blotting, we... περισσότερα »
Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ
Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ: Abstract Adipsic (or essential) hypernatremia is a rare hypernatremia caused by a deficiency in thirst regulation and vasopressin release. In 2010, we reported a case in which autoantibodies targeting the sensory circumventricular organs (sCVOs) caused adipsic hypernatremia without hypothalamic structural lesions demonstrable by magnetic resonance imaging (MRI); sCVOs include the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), which are centers for ... περισσότερα »
Rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma
Reclassification of rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma with complete loss of SMARCB1/INI1 protein expression: three subtypes of rhabdoid tumor according to their histological features: Kenichi Kohashi, Yukichi Tanaka, Hiroshi Kishimoto, Hidetaka Yamamoto, Yuichi Yamada, Tomoaki Taguchi, Yukihide Iwamoto andYoshinao Oda Abstract Rhabdoid tumor is characterized by rhabdoid cells and shows complete loss of SMARCB1/INI1 protein expression. In existing classifications, the diagnostic synonyms vary depending on the anatomic site: rhabdoid tumors in th... περισσότερα »
Sublingual Administration of Drugs: Be Cautious
Sublingual Administration of Drugs: Be Cautious: [image: PdfPageImage.00000539-201607000-00038.0.] http://ift.tt/28XAiGc OtoRhinoLaryngology by Alexandros G. Sfakianakis
Inhaled Anesthetics & Ventilator-Induced Lung Injury
Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury: BACKGROUND: Mechanical ventilation is an important perioperative tool in anesthesia and a lifesaving treatment for respiratory failure, but it can lead to ventilator-associated lung injury. Inhaled anesthetics have demonstrated protective properties in various models of organ damage. We compared the lung-protective potential of inhaled sevoflurane, isoflurane, and desflurane in a mouse model of ventilator-induced lung injury (VILI). METHODS: C57BL/6N mice were randomized int... περισσότερα »
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. from #ENT via xlomafota13 on Inoreader http://ift.tt/297xR5r via IFTTT
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. http://ift.tt/297xR5r
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Summary Objective To determine the bioequivalence of brivaracetam oral tablet formulations (10, 75, and 100 mg) versus 50 mg oral tablet and to compare the bioavailability of brivaracetam 100 mg intravenous (i.v.) bolus versus 50 and 100 mg tablets, in healthy participants. Methods Phase 1, randomized, open-label, five-period crossover study. Participants received five single doses of brivaracetam: 10, 50 (reference), 75, and 100 mg oral tablets; 100 mg, i.v., bolus injection. Pharmacokinetic parameters (maximum plasma concentration [Cmax], area under the plasma concentration-ti... περισσότερα »
The Risk Factors for Refractory Fistula after Esophagectomy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
with Gastric Tube Reconstruction in Patients with Esophageal Cancer.: Dig Surg. 2016 Jun 24;34(1):18-24 Authors: Yamana I, Takeno S, Yamada T, Sato K, Hashimoto T, Yamashita Y Abstract BACKGROUND/AIMS: Anastomotic leakage (AL) after esophagectomy is associated with high rates of postoperative morbidity and mortality. In cases with leakage, a refractory fistula (RF) is sometimes recognized […]
Capsule endoscopy (CE)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy: A Multicenter Retrospective Study: Abstract Background Accurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to […]
Esophageal motility disorders and possibly gastroesophageal reflux disease are common in patients with diabetes mellitus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Esophageal Epithelial Resistance and Lower Esophageal Sphincter Muscle Contraction Increase in a Chronic Diabetic Rabbit Model: Abstract Background Esophageal motility disorders and possibly gastroesophageal reflux disease are common in patients with diabetes mellitus. Aims We aimed to investigate both the electrophysiological characteristics of the esophageal epithelium and the contractility of the lower esophageal sphincter (LES) […]
Thoracoscopic and Laparoscopic Enucleation of Esophageal Leiomyomas.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Although infrequent, esophageal leiomyomas are the most common benign intramural tumors of the esophagus. As malignant potential is not a concern in these lesions, they represent ideal candidates for an organ-preserving approach. Due to their well-circumscribed growth, a minimally invasive approach should be pursued in almost all patients. We present our recent techniques and results […]
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Summary Objective To determine the bioequivalence of brivaracetam oral tablet formulations (10, 75, and 100 mg) versus 50 mg oral tablet and to compare the bioavailability of brivaracetam 100 mg intravenous (i.v.) bolus versus 50 and 100 mg tablets, in healthy participants. Methods Phase 1, randomized, open-label, five-period crossover study. Participants received five single doses […]
EGFR/KRAS mutations of plasma cell free DNA of patients with lung cancer and esophageal cancer
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
[Clinical implications of the concentration and EGFR/KRAS mutations of plasma cell free DNA of patients with lung cancer and esophageal cancer].: Zhonghua Yi Xue Za Zhi. Authors: Zhang R, Li Y, Chen Y, Liu X, Wang Z, Sun H, Zheng Y, Ding Z, Lan L, Li M, Qin J, Chen X Abstract OBJECTIVE: To analyze […]
Plasma taurine levels are not affected by vigabatrin in pediatric patients
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Summary Vigabatrin is a highly effective antiseizure medication, but its use is limited due to concerns about retinal toxicity. One proposed mechanism for this toxicity is vigabatrin-mediated reduction of taurine. Herein we assess plasma taurine levels in a retrospective cohort of children with epilepsy, including a subset receiving vigabatrin. All children who underwent a plasma […]
Thoracic Esophageal Squamous Cell Carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Optimal Adjuvant Treatment for Curatively Resected Thoracic Esophageal Squamous Cell Carcinoma: A Radiotherapy Perspective.: Cancer Res Treat. 2016 Jun 23; Authors: Kim KH, Chang JS, Cha JH, Lee IJ, Kim DJ, Cho BC, Park KR, Lee CG Abstract Purpose: To evaluate the benefits of adjuvant treatment for curatively resected thoracic esophageal squamous cell carcinoma (ESCC) […]
Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
A Meta-Analysis of Epidemiologic Studies Nutrients. 2016;8(6) Authors: Cui L, Liu X, Tian Y, Xie C, Li Q, Cui H, Sun C Abstract Flavonoids have been suggested to play a chemopreventive role in carcinogenesis. However, the epidemiologic studies assessing dietary intake of flavonoids and esophageal cancer risk have yielded inconsistent results. This study was designed […]
XRCC4 expression in esophageal cancer cells on the response to radiotherapy.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Influence of Med Mol Morphol. 2016 Jun 23; Authors: Hori M, Someya M, Matsumoto Y, Nakata K, Kitagawa M, Hasegawa T, Tsuchiya T, Fukushima Y, Gocho T, Sato Y, Ohnuma H, Kato J, Sugita S, Hasegawa T, Sakata KI Abstract DNA double-strand break (DSB) is one of the most serious forms of damage induced by […]
Post-arrest stalling rather than crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro
Although CD8+ T cells have been implied in the pathogenesis of multiple sclerosis (MS), the molecular mechanisms mediating CD8+ T-cell migration across the blood-brain barrier (BBB) into the central nervous system (CNS) are ill defined. Using in vitro live cell imaging, we directly compared the multi-step extravasation of activated CD4+ and CD8+ T cells across… Continue reading Post-arrest stalling rather than crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro
Ki-67 in tumor tissue is probably a more reliable marker than serum SCCA and CYFRA 21-1 in predicting the clinical course of ESCC
Correlation between Serum SCCA and CYFRA 2 1-1, Tissue Ki-67, and Clinicopathological Factors in Patients with Esophageal Squamous Cell Carcinoma.: J Med Assoc Thai. 2016 ; Authors: Sunpaweravong S, Puttawibul P, Sunpaweravong P, Nitiruangjaras A, Boonyaphiphat P, Kemapanmanus M Abstract BACKGROUND: Squamous cell carcinoma antigen (SCCA) and CYFRA 21-1 have been reported as useful tumor… Continue reading Ki-67 in tumor tissue is probably a more reliable marker than serum SCCA and CYFRA 21-1 in predicting the clinical course of ESCC
Selective depletion of CD11c+CD11b+ dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE
Intravenous (i.v.) injection of a soluble myelin antigen can induce tolerance, which effectively ameliorates experimental autoimmune encephalomyelitis (EAE). We have previously shown that i.v. MOG induces tolerance in EAE and expands a subpopulation of tolerogenic CD11c+CD11b+ dendritic cells (DCs) with an immature phenotype having low expression of IA and co-stimulatory molecules CD40, CD86, and CD80.… Continue reading Selective depletion of CD11c+CD11b+ dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE
SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
Invariant Natural Killer T (iNKT) cells differentiate in the thymus into three distinct lineages defined by their cytokine and transcription factor expression. SLAM-associated protein (SAP) is essential for early stages of iNKT cell development, but its role during terminal differentiation of iNKT1, iNKT2 or iNKT17 cells remains unclear. Taking advantage of SAP-deficient mice expressing a… Continue reading SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
Feasibility and Utility of Chest-X ray on Portable Normothermic Perfusion System.
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/28ULJlX from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XJLOP via IFTTT
Subjective health complaints predict functional outcome six months after stroke
Objectives Cerebrovascular stroke is a main cause of lasting disability in older age, and initial stroke severity has been established as a main determinant for the degree of functional loss. In this study, we searched for other predictors of functional outcome in a cohort of stroke patients participating in an early supported discharge randomised controlled… Continue reading Subjective health complaints predict functional outcome six months after stroke
Safeguarding Fertility With Whole Ovary Cryopreservation and Microvascular Transplantation: Higher Follicular Survival With Vitrification Than With Slow Freezing in a Ewe Model.
Background: In young women, ovarian cortex cryopreservation before gonadotoxic chemotherapy and its avascular grafting after cancer healing permitted fertility restoration. However, ischemia reduced the grafts’ lifespan. Microvascular transplantation of cryopreserved whole ovary may allow immediate revascularization, ensuring better fertility preservation, but the best cryopreservation method is unknown. We aimed to compare slow freezing and vitrification… Continue reading Safeguarding Fertility With Whole Ovary Cryopreservation and Microvascular Transplantation: Higher Follicular S... περισσότερα »
Association of Pretransplant Skin Cancer With Posttransplant Malignancy, Graft Failure and Death in Kidney Transplant Recipients.
Background: Posttransplant malignancy (PTM) is one of the leading causes of late death in kidney recipients. Those with a cancer history may be more prone to develop a recurrent or a new cancer. We studied the association between pretransplant skin cancer, PTM, death, and graft failure. Methods: Primary adult kidney recipients transplanted between 2005 and… Continue reading Association of Pretransplant Skin Cancer With Posttransplant Malignancy, Graft Failure and Death in Kidney Transplant Recipients.
Long-Term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients.
Background: Limited data are available regarding the long-term metabolic outcomes of functioning pancreas transplants in patients with type 2 diabetes mellitus (T2DM). Methods: To compare the long-term effects of pancreas transplantation in terms of insulin resistance and [beta] cell function, comparison of metabolic variables was performed between type 1 diabetes mellitus (T1DM) and T2DM patients… Continue reading Long-Term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients.
Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads Assay.
Background: In virtual crossmatch (XM) strategies, a correct anticipation of XM results is required for appropriately allocating organs. We reassessed the ability to predict T lymphocyte flow cytometry and complement dependent cytotoxicity XM results with the mean fluorescence intensity (MFI) in Luminex class I single antigen flow beads (SAFB) assay, after correction of complement interference… Continue reading Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads Assay.
Endoxifen, a New Treatment Option for Mania: A Double-Blind, Active-Controlled Trial Demonstrates the Antimanic Efficacy of Endoxifen
The protein kinase C (PKC) signaling system plays a role in mood disorders and PKC inhibitors such as endoxifen may be an innovative medicine for bipolar disorder (BP) patients. In this study we show for the first time the antimanic properties of endoxifen in patients with bipolar I disorder (BPD I) with current manic or mixed episode. In a double-blind, active-controlled study, 84 subjects with BPD I were randomly assigned to receive endoxifen (4 mg/day or 8 mg/day) or divalproex in a 2:1 ratio. Patients orally administered 4 mg/day or 8 mg/day endoxifen showed significant impro... περισσότερα »
Plasma taurine levels are not affected by vigabatrin in pediatric patients
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
Summary Vigabatrin is a highly effective antiseizure medication, but its use is limited due to concerns about retinal toxicity. One proposed mechanism for this toxicity is vigabatrin-mediated reduction of taurine. Herein we assess plasma taurine levels in a retrospective cohort of children with epilepsy, including a subset receiving vigabatrin. All children who underwent a plasma amino acid analysis as part of their clinical evaluation between 2006 and 2015 at Stanford Children's Health were included in the analysis. There were no significant differences in plasma taurine levels be... περισσότερα »
OtoRhinoLaryngology
3h OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Impaired bolus clearance in asymptomatic older adults during high-resolution impedance manometry Abstract Background Dysphagia becomes more common in old age. We performed high-resolution impedance manometry (HRIM) in asymptomatic healthy adults (including an older cohort >80 years) to assess HRIM findings in relation to bolus clearance. Methods Esophageal HRIM was performed in... 20h OtoRhinoLaryngology Human Foramen Magnum Area and Posterior Cranial Fossa Volume Growth in Relation to C... περισσότερα »
Plasma taurine levels are not affected by vigabatrin in pediatric patients
Summary Vigabatrin is a highly effective antiseizure medication, but its use is limited due to concerns about retinal toxicity. One proposed mechanism for this toxicity is vigabatrin-mediated reduction of taurine. Herein we assess plasma taurine levels in a retrospective cohort of children with epilepsy, including a subset receiving vigabatrin. All children who underwent a plasma amino acid analysis as part of their clinical evaluation between 2006 and 2015 at Stanford Children's Health were included in the analysis. There were no significant differences in plasma taurine levels be... περισσότερα »
Subjective health complaints predict functional outcome six months after stroke
Objectives Cerebrovascular stroke is a main cause of lasting disability in older age, and initial stroke severity has been established as a main determinant for the degree of functional loss. In this study, we searched for other predictors of functional outcome in a cohort of stroke patients participating in an early supported discharge randomised controlled trial. Methods Thirty candidate variables related either to premorbid history or to the acute stroke were examined by ordered logistic regression in 229 stroke patients. Dependent variables were modified Rankin Scale (mRS) at 6 ... περισσότερα »
Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads Assay.
Background: In virtual crossmatch (XM) strategies, a correct anticipation of XM results is required for appropriately allocating organs. We reassessed the ability to predict T lymphocyte flow cytometry and complement dependent cytotoxicity XM results with the mean fluorescence intensity (MFI) in Luminex class I single antigen flow beads (SAFB) assay, after correction of complement interference and exclusion of antidenatured HLA antibodies. Methods: Among 432 XM with T lymphocytes (T-XM), 407 were analyzed after exclusion of antidenatured HLA antibodies. Only ethylenediaminetetraacet... περισσότερα »
Malignant progression of esophageal squamous cell carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Aberrant methylation-mediated downregulation of long noncoding RNA LOC100130476 correlates with malignant progression of esophageal squamous cell carcinoma.: Dig Liver Dis. 2016 Jun; Authors: Guo W, Dong Z, Shi Y, Liu S, Liang J, Guo Y, Guo X, Shen S, Shan B Abstract BACKGROUND: Dysregulated long non-coding RNAs (lncRNAs) are involved in many complicated human diseases […]
Thymoma Complicating Myasthenia Gravis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
[Postoperative Survival for Patients with Thymoma Complicating Myasthenia Gravis - Preliminary Retrospective Results of the ChART Database].: Zhongguo Fei Ai Za Zhi. 2016 Jul 20;19(7):418-24 Authors: Wang F, Pang L, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, […]
The Masaoka-Koga and The IASLC/ITMIG Proposal for The TNM Staging Systems Based on the Chinese Alliance for Research in Thymomas (ChART)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
[Comparison of the Masaoka-Koga and The IASLC/ITMIG Proposal for The TNM Staging Systems Based on the Chinese Alliance for Research in Thymomas (ChART) Retrospective Database].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):425-36 Authors: Liang G, Gu Z, Li Y, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, […]
Pretreatment Biopsy for Histological Diagnosis and Induction Therapy in Thymic Tumors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
[Pretreatment Biopsy for Histological Diagnosis and Induction Therapy in Thymic Tumors].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):437-44 Authors: Yue J, Gu Z, Yu Z, Zhang H, Ma Z, Liu Y, Fang W, Members of the Chinese Alliance for Research in Thymomas Abstract BACKGROUND: The aim of this study is to investigate the value […]
Locally Advanced Thymic Tumors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
[Preoperative Induction Therapy for Locally Advanced Thymic Tumors: A Retrospective Analysis Using the ChART Database].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):445-52 Authors: Wei Y, Gu Z, Shen Y, Fu J, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Pang […]
Clinically Early-stage Thymic Malignancies: Video-assisted Thoracoscopic Thymectomy versus Open Approaches
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
[Perioperative Outcomes and Long-term Survival in Clinically Early-stage Thymic Malignancies: Video-assisted Thoracoscopic Thymectomy versus Open Approaches].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):453-8 Authors: Wang H, Gu Z, Ding J, Tan L, Fu J, Shen Y, Wei Y, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, […]
Thymectomy versus Tumor Resection for Early-stage Thymic Malignancies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
A Chinese Alliance for Research in Thymomas (ChART) Retrospective Database Analysis].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):459-64 Authors: Gu Z, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou […]
Postoperative Radiotherapy for Stage I/II/III Thymic Tumor
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
[Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor – Results of the ChART Retrospective Database].: Zhongguo Fei Ai Za Zhi. 2016 Jul ;19(7):465-72 Authors: Liu Q, Gu Z, Yang F, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen KN, Chen H, Liu Y, […]
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Objective To determine the bioequivalence of brivaracetam oral tablet formulations (10, 75, and 100 mg) versus 50 mg oral tablet and to compare the bioavailability of brivaracetam 100 mg intravenous (i.v.) bolus versus 50 and 100 mg tablets, in healthy participants. Methods Phase 1, randomized, open-label, five-period crossover study. Participants received five single doses […]
Plasma taurine levels are not affected by vigabatrin in pediatric patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Vigabatrin is a highly effective antiseizure medication, but its use is limited due to concerns about retinal toxicity. One proposed mechanism for this toxicity is vigabatrin-mediated reduction of taurine. Herein we assess plasma taurine levels in a retrospective cohort of children with epilepsy, including a subset receiving vigabatrin. All children who underwent a plasma […]
Fatal familial insomnia: Mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus
Fatal familial insomnia: Mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus: Abstract The expression of subunits of mitochondrial respiratory complexes and components of the protein synthesis machinery from the nucleolus to the ribosome was analyzed in the mediodorsal thalamus in seven cases of Fatal Familial Insomnia (FFI) compared with age-matched controls. NDUFB8 (complex… Continue reading Fatal familial insomnia: Mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus
Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ
Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ: Abstract Adipsic (or essential) hypernatremia is a rare hypernatremia caused by a deficiency in thirst regulation and vasopressin release. In 2010, we reported a case in which autoantibodies targeting the sensory circumventricular organs (sCVOs) caused adipsic hypernatremia without hypothalamic structural lesions demonstrable by magnetic… Continue reading Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ
Rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma
Reclassification of rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma with complete loss of SMARCB1/INI1 protein expression: three subtypes of rhabdoid tumor according to their histological features: Kenichi Kohashi, Yukichi Tanaka, Hiroshi Kishimoto, Hidetaka Yamamoto, Yuichi Yamada, Tomoaki Taguchi, Yukihide Iwamoto andYoshinao Oda Abstract Rhabdoid tumor is characterized by rhabdoid cells and shows complete loss of SMARCB1/INI1… Continue reading Rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma
Sublingual Administration of Drugs: Be Cautious
Sublingual Administration of Drugs: Be Cautious: from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XAiGc via IFTTT
Inhaled Anesthetics & Ventilator-Induced Lung Injury
Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury: BACKGROUND: Mechanical ventilation is an important perioperative tool in anesthesia and a lifesaving treatment for respiratory failure, but it can lead to ventilator-associated lung injury. Inhaled anesthetics have demonstrated protective properties in various models of organ damage. We compared the lung-protective… Continue reading Inhaled Anesthetics & Ventilator-Induced Lung Injury
OtoRhinoLaryngology
3h OtoRhinoLaryngology – Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Impaired bolus clearance in asymptomatic older adults during high-resolution impedance manometry Abstract Background Dysphagia becomes more common in old age. We performed high-resolution impedance manometry (HRIM) in asymptomatic healthy adults (including an older cohort >80 years) to assess HRIM findings in relation to bolus… Continue reading OtoRhinoLaryngology
Identification of the First In Silico-designed TREK1 Antagonists that Block Channel Currents Dose-dependently
Abstract TREK1 (Twik-RElated Potassium (K+) channel 1), though a well characterized target for several neuropsychiatric disorders, underwent very few explorations for prototypic inhibitors. This study aimed to find diverse chemotypes by an in silico means. Homology-built TREK1 on docking with high affinity quaternary ammonium compounds (QAs) corroborated the previous findings by recreating the binding mode… Continue reading Identification of the First In Silico-designed TREK1 Antagonists that Block Channel Currents Dose-dependently
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