Real-time dual visualization of two different modalities for the evaluation of vocal fold vibration - Laryngeal videoendoscopy and 2D scanning videokymography: Preliminary report.
Alexandros G. SfakianakisστοHead and NeckΠριν από 34 δευτερόλεπτα
*Real-time dual visualization of two different modalities for the evaluation of vocal fold vibration - Laryngeal videoendoscopy and 2D scanning videokymography: Preliminary report.* Auris Nasus Larynx. 2016 Jul 12; Authors: Kim GH, Wang SG, Lee BJ, Park HJ, Kim YC, Kim HS, Sohn KT, Kwon SB Abstract OBJECTIVE: Currently, various tools have been introduced for the assessment of vocal fold vibration: laryngeal videolaryngoscopy (LV), videokymography (VKG), high speed videoendoscopy (HSV), digital videokymography (DKG), and 2D scanning videokymography (2D VKG). Among these, the author... περισσότερα »
Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 34 δευτερόλεπτα
*Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study.* Allergol Int. 2016 Jul 12; Authors: Okubo K, Gotoh M, Asako M, Nomura Y, Togawa M, Saito A, Honda T, Ohashi Y Abstract BACKGROUND: Bilastine, a novel non-sedating second-generation H1 antihistamine, has been approved in most European countries since 2010. This study aimed to evaluate the superiority of bilastine over placebo in Japanese patients with perennial allergic rhinitis (PAR). METHODS: This r... περισσότερα »
Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 34 δευτερόλεπτα
*Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis.* BMC Cancer. 2016;16(1):486 Authors: Somasundaram RT, Kaur J, Leong I, MacMillan C, Witterick IJ, Walfish PG, Ralhan R Abstract BACKGROUND: Identification of patients with oral dysplasia at high risk of cancer development and oral squamous cell carcinoma (OSCC) at increased risk of disease recurrence will enable rigorous personalized treatment. Regulated intramembranous proteolysis of Epithelial cell adhesion molecule (EpCAM) resulting in release of it... περισσότερα »
Comparison of Learning Curves for Retroauricular and Transaxillary Endoscopic Hemithyroidectomy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 34 δευτερόλεπτα
*Comparison of Learning Curves for Retroauricular and Transaxillary Endoscopic Hemithyroidectomy.* Ann Surg Oncol. 2016 Jul 15; Authors: Lee DY, Oh DJ, Kang KR, Kim MS, Oh KH, Baek SK, Kwon SY, Woo JS, Jung KY Abstract OBJECTIVE: This study aimed to evaluate and compare learning curves for the retroauricular (RA) and transaxillary (TA) approaches in endoscopic hemithyroidectomy. METHODS: The medical records of 290 patients who underwent hemithyroidectomy by either the RA or TA approach from November 2007 through December 2015 were retrospectively reviewed (113 patients with RA a... περισσότερα »
Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 λεπτό
*Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst.* Eur Arch Otorhinolaryngol. 2016 Jul 15; Authors: Kim SM, Eo MY, Cho YJ, Kim YS, Lee SK Abstract Both maxillary sinusitis (MS) and maxillary retention cyst (MRC) involve the maxillary sinus and show similar clinical features. Clinically, differentiating between MS and MRC is sometimes difficult in asymptomatic patients, despite their quite different pathogenic behaviors. To identify differential protein expressions in the secretory fluids of MS and MRC, 25 cases of asympt... περισσότερα »
Intraoperative monitoring of the recurrent laryngeal nerve by vagal nerve stimulation in thyroid surgery.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 λεπτό
*Intraoperative monitoring of the recurrent laryngeal nerve by vagal nerve stimulation in thyroid surgery.* Eur Arch Otorhinolaryngol. 2016 Jul 15; Authors: Farizon B, Gavid M, Karkas A, Dumollard JM, Peoc'h M, Prades JM Abstract The aim of the present study was to evaluate the thyroarytenoid muscle response during bilateral thyroid surgery using vagal nerve stimulation. 195 patients (390 nerves at risk) underwent a total thyroidectomy. The recurrent laryngeal nerve's function was checked by analyzing the amplitude and the latency of the thyroarytenoid muscle's responses after a v... περισσότερα »
Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 λεπτό
*Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease.* Eur Arch Otorhinolaryngol. 2016 Jul 15; Authors: Maxwell R, Jerin C, Gürkov R Abstract To determine whether vestibular evoked myogenic potential (VEMP) measurements that combine the VEMP 500/1000 Hz frequency tuning ratio and the inter-aural asymmetry ratio can reliably detect unilateral Meniere's disease ears as compared to healthy controls. Forty-two consecutive patients with certain unilateral Meniere's disease (as confirmed using a locally enhanced inner ear MRI (LEIM)) were assessed. C... περισσότερα »
Frequency of and factors associated with positive or equivocal margins in conventional excision of atypical intraepidermal melanocytic proliferations (AIMP): A single academic institution cross-sectional study.
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 3 δευτερόλεπτα
*Frequency of and factors associated with positive or equivocal margins in conventional excision of atypical intraepidermal melanocytic proliferations (AIMP): A single academic institution cross-sectional study.* J Am Acad Dermatol. 2016 Jul 12; Authors: Zhang J, Miller CJ, Sobanko JF, Shin TM, Etzkorn JR Abstract BACKGROUND: No evidence-based surgical guidelines exist for atypical intraepidermal melanocytic proliferation (AIMP), a descriptive histopathologic diagnosis with uncertain malignant potential. OBJECTIVE: We sought to identify the frequency of and risk factors associated... περισσότερα »
Frequency of and factors associated with positive or equivocal margins in conventional excision of atypical intraepidermal melanocytic proliferations (AIMP): A single academic institution cross-sectional study.
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 3 δευτερόλεπτα
*Frequency of and factors associated with positive or equivocal margins in conventional excision of atypical intraepidermal melanocytic proliferations (AIMP): A single academic institution cross-sectional study.* J Am Acad Dermatol. 2016 Jul 12; Authors: Zhang J, Miller CJ, Sobanko JF, Shin TM, Etzkorn JR Abstract BACKGROUND: No evidence-based surgical guidelines exist for atypical intraepidermal melanocytic proliferation (AIMP), a descriptive histopathologic diagnosis with uncertain malignant potential. OBJECTIVE: We sought to identify the frequency of and risk factors associated... περισσότερα »
Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor-κB Signaling for Cancer Treatment.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
*Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor-κB Signaling for Cancer Treatment.* Clin Cancer Res. 2016 Jul 15; Authors: Zeligs KP, Neuman MK, Annunziata CM Abstract The Nuclear Factor-κB (NF-κB) signaling pathway is a complex network linking extracellular stimuli to cell survival and proliferation. Cytoplasmic signaling to activate NF-kB can occur as part of the DNA damage response or in response to a large variety of activators including viruses, inflammation, and cell death. NF-κB transc... περισσότερα »
TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
*TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells.* Endocr Relat Cancer. 2016 Jul 15; Authors: Palladino G, Notarangelo T, Pannone G, Piscazzi A, Lamacchia O, Sisinni L, Spagnoletti G, Toti P, Santoro A, Storto G, Bufo P, Cignarelli M, Esposito F, Landriscina M Abstract TRAP1 is a HSP90 molecular chaperone, upregulated in several human malignancies and involved in protection from apoptosis and drug resistance, cell cycle progression, cell metabolism and quality control of specific client proteins. TRAP1 role in thyroid carcinoma (TC), still unaddressed at prese... περισσότερα »
Unusual aetiology of a hilar mass in a man with history of thyroid cancer.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
*Unusual aetiology of a hilar mass in a man with history of thyroid cancer.* Thorax. 2016 Jul 15; Authors: Vial MR, Stewart J, Lazarus DR, Eapen GA, Ost DE, Grosu HB, Jimenez CA PMID: 27422794 [PubMed - as supplied by publisher] from pubmed: thyroid cancer http://ift.tt/2a2Kgb1 via IFTTT
Surgical safety and oncological completeness of robotic thyroidectomy for thyroid carcinoma larger than 2 cm.
Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
*Surgical safety and oncological completeness of robotic thyroidectomy for thyroid carcinoma larger than 2 cm.* Surg Endosc. 2016 Jul 15; Authors: Chai YJ, Suh H, Woo JW, Yu HW, Song RY, Kwon H, Lee KE Abstract BACKGROUND: The safety of robotic thyroidectomy (RT) for small-sized thyroid carcinomas has been well established. The surgical outcomes of bilateral axillo-breast approach RT for thyroid carcinomas larger than 2 cm were evaluated and compared with those of open thyroidectomy (OT). METHODS: The medical records of patients who underwent total thyroidectomy or hemithyroidecto... περισσότερα »
Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor-κB Signaling for Cancer Treatment.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor-κB Signaling for Cancer Treatment.* Clin Cancer Res. 2016 Jul 15; Authors: Zeligs KP, Neuman MK, Annunziata CM Abstract The Nuclear Factor-κB (NF-κB) signaling pathway is a complex network linking extracellular stimuli to cell survival and proliferation. Cytoplasmic signaling to activate NF-kB can occur as part of the DNA damage response or in response to a large variety of activators including viruses, inflammation, and cell death. NF-κB transc... περισσότερα »
TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells.* Endocr Relat Cancer. 2016 Jul 15; Authors: Palladino G, Notarangelo T, Pannone G, Piscazzi A, Lamacchia O, Sisinni L, Spagnoletti G, Toti P, Santoro A, Storto G, Bufo P, Cignarelli M, Esposito F, Landriscina M Abstract TRAP1 is a HSP90 molecular chaperone, upregulated in several human malignancies and involved in protection from apoptosis and drug resistance, cell cycle progression, cell metabolism and quality control of specific client proteins. TRAP1 role in thyroid carcinoma (TC), still unaddressed at prese... περισσότερα »
Unusual aetiology of a hilar mass in a man with history of thyroid cancer.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Unusual aetiology of a hilar mass in a man with history of thyroid cancer.* Thorax. 2016 Jul 15; Authors: Vial MR, Stewart J, Lazarus DR, Eapen GA, Ost DE, Grosu HB, Jimenez CA PMID: 27422794 [PubMed - as supplied by publisher] http://ift.tt/2a2Kgb1
Surgical safety and oncological completeness of robotic thyroidectomy for thyroid carcinoma larger than 2 cm.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Surgical safety and oncological completeness of robotic thyroidectomy for thyroid carcinoma larger than 2 cm.* Surg Endosc. 2016 Jul 15; Authors: Chai YJ, Suh H, Woo JW, Yu HW, Song RY, Kwon H, Lee KE Abstract BACKGROUND: The safety of robotic thyroidectomy (RT) for small-sized thyroid carcinomas has been well established. The surgical outcomes of bilateral axillo-breast approach RT for thyroid carcinomas larger than 2 cm were evaluated and compared with those of open thyroidectomy (OT). METHODS: The medical records of patients who underwent total thyroidectomy or hemithyroidecto... περισσότερα »
Applying Subtractive Hybridization Technique to Enrich and Amplify Tumor-Specific Transcripts of Esophageal Squamous Cell Carcinoma.
Alexandros G. SfakianakisστοThe OesophagusΠριν από 6 δευτερόλεπτα
*Applying Subtractive Hybridization Technique to Enrich and Amplify Tumor-Specific Transcripts of Esophageal Squamous Cell Carcinoma.* Pathol Oncol Res. 2016 Jul 15; Authors: Mahmoudian RA, Abbaszadegan MR, Gholamin M Abstract Subtractive hybridization (SH) as an efficient and powerful approach can be applied to isolate differentially expressed transcripts as well as detect of involved mRNAs in various cellular processes, particularly diseases and malignancies. This procedure leads to the enrichment of specific low copy transcripts of tumor cells. Having developed a new approach f... περισσότερα »
Interstitial Cells of Cajal in Deep Esophageal Leiomyoma: Immunohistochemical Mimics of Gastrointestinal Stromal Tumor.
Alexandros G. SfakianakisστοThe OesophagusΠριν από 6 δευτερόλεπτα
*Interstitial Cells of Cajal in Deep Esophageal Leiomyoma: Immunohistochemical Mimics of Gastrointestinal Stromal Tumor.* Int J Surg Pathol. 2016 Jul 15; Authors: Hallin M, Mudan S, Thway K Abstract Gastrointestinal stromal tumors (GISTs) are potentially aggressive mesenchymal neoplasms with spindle cell, epithelioid, or mixed morphology. They typically express CD117, DOG1, and CD34 and can be diffusely and strongly positive for h-caldesmon. Leiomyomas are benign smooth muscle neoplasms that can arise in a variety of visceral and soft tissue sites, including the gastrointestinal ... περισσότερα »
Cancer risk in waterpipe smokers: a meta-analysis.
Alexandros G. SfakianakisστοThe OesophagusΠριν από 6 δευτερόλεπτα
*Cancer risk in waterpipe smokers: a meta-analysis.* Int J Public Health. 2016 Jul 15; Authors: Mamtani R, Cheema S, Sheikh J, Al Mulla A, Lowenfels A, Maisonneuve P Abstract OBJECTIVES: To quantify by meta-analysis the relationship between waterpipe smoking and cancer, including cancer of the head and neck, esophagus, stomach, lung and bladder. METHODS: We performed a systematic literature search to identify relevant studies, scored their quality, used fixed and random-effect models to estimate summary relative risks (SRR), evaluated heterogeneity and publication bias. RESULTS: ... περισσότερα »
Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst.
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst.* Eur Arch Otorhinolaryngol. 2016 Jul 15; Authors: Kim SM, Eo MY, Cho YJ, Kim YS, Lee SK Abstract Both maxillary sinusitis (MS) and maxillary retention cyst (MRC) involve the maxillary sinus and show similar clinical features. Clinically, differentiating between MS and MRC is sometimes difficult in asymptomatic patients, despite their quite different pathogenic behaviors. To identify differential protein expressions in the secretory fluids of MS and MRC, 25 cases of asympt... περισσότερα »
Intraoperative monitoring of the recurrent laryngeal nerve by vagal nerve stimulation in thyroid surgery.
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*Intraoperative monitoring of the recurrent laryngeal nerve by vagal nerve stimulation in thyroid surgery.* Eur Arch Otorhinolaryngol. 2016 Jul 15; Authors: Farizon B, Gavid M, Karkas A, Dumollard JM, Peoc'h M, Prades JM Abstract The aim of the present study was to evaluate the thyroarytenoid muscle response during bilateral thyroid surgery using vagal nerve stimulation. 195 patients (390 nerves at risk) underwent a total thyroidectomy. The recurrent laryngeal nerve's function was checked by analyzing the amplitude and the latency of the thyroarytenoid muscle's responses after a v... περισσότερα »
Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease.
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease.* Eur Arch Otorhinolaryngol. 2016 Jul 15; Authors: Maxwell R, Jerin C, Gürkov R Abstract To determine whether vestibular evoked myogenic potential (VEMP) measurements that combine the VEMP 500/1000 Hz frequency tuning ratio and the inter-aural asymmetry ratio can reliably detect unilateral Meniere's disease ears as compared to healthy controls. Forty-two consecutive patients with certain unilateral Meniere's disease (as confirmed using a locally enhanced inner ear MRI (LEIM)) were assessed. C... περισσότερα »
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 12 δευτερόλεπτα
Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Kaori Mukai, Nicolas Gaudenzio, Sheena Gupta, Nora Vivanco, Sean C. Bendall, Holden T. Maecker, Rebecca S. Chinthrajah, Mindy Tsai, Kari C. Nadeau, Stephen J. Galli BackgroundBasophil activation tests (BATs) have promise for research and for clinical monitoring of subjects with allergies. However, BAT protocols vary in blood anticoagulant used and temperature and time of storage before testing, complicating comparisons of results from various studies.ObjectiveTo attempt to ... περισσότερα »
Diversity of T-helper cytokine-profiles in chronic rhinosinusitis: A multicenter study in Europe, Asia and Oceania
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 12 δευτερόλεπτα
Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Xiangdong Wang, Nan Zhang, Mingyu Bo, Gabriele Holtappels, Ming Zheng, Hongfei Lou, Hong Wang, Luo Zhang, Claus Bachert BackgroundTo date no study has evaluated the diversity of T-helper cell cytokine patterns of chronic rhinosinusitis (CRS) patients among centers in different continents employing identical methods.ObjectiveTo assess T-helper cytokine-profiles in CRS patients from Europe, Asia and Australia.MethodCRS patients with (CRSwNP) and without nasal polyps (CRSsNP) ... περισσότερα »
Effect of Chlorhexidine Bathing Every Other Day on Prevention of Hospital-Acquired Infections in the Surgical ICU: A Single-Center, Randomized Controlled Trial.
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Objective: To test the hypothesis that compared with daily soap and water bathing, 2% chlorhexidine gluconate bathing every other day for up to 28 days decreases the risk of hospital-acquired catheter-associated urinary tract infection, ventilator-associated pneumonia, incisional surgical site infection, and primary bloodstream infection in surgical ICU patients. Design: This was a single-center, pragmatic, randomized trial. Patients and clinicians were aware of treatment-group assignment; investigators who determined outcomes were blinded. Setting: Twenty-four-bed surgical ICU at a... περισσότερα »
Global Trends in Extracorporeal Membranous Oxygenation Use and Survival of Patients With Influenza-Associated Illness.
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Objectives: To determine the overall use of extracorporeal membranous oxygenation for influenza-associated illness and describe risk factors associated with mortality in these patients. Design: Retrospective multicenter cohort analysis. Setting: The international Extracorporeal Life Support Organization database was queried for patients with influenza-associated illness on extracorporeal membranous oxygenation from 1992 to 2014. Patients: In total, 1,654 patients with influenza-associated illness on extracorporeal membranous oxygenation. Interventions: None. Measurements and Main Re... περισσότερα »
A More Rapid, Rapid Response.
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Objectives: Critical care physicians' standard for arrival to a rapid response team activation is 10 minutes or less at this institution. This study proposes that a FaceTime (Apple, Cupertino, CA) video call between the staff at the bedside and the critical care physician will allow the implementation of potentially life-saving therapies earlier than the current average response (4.5 min). Design: Prospective cohort study. Setting: Freestanding, tertiary-care children's hospital. Patients: Pediatric patients ages 0-17. Interventions: Six units were chosen as matched pairs. In the te... περισσότερα »
Circuit Lifetime With Citrate Versus Heparin in Pediatric Continuous Venovenous Hemodialysis.
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Objectives: To determine if there is a difference between regional citrate and global heparinized anticoagulation on circuit lifetimes during continuous venovenous hemodialysis in children. Design: Prospective "cross-over" trial. Setting: PICU, Department of Pediatrics, University Hospital Ostrava. Patients: Children 0-18 years old. Interventions: From 2009 to 2014, 63 eligible children (age, 89.24 +/- 62.9 mo; weight, 30.37 +/- 20.62 kg) received at least 24 hours of continuous venovenous hemodialysis. Each child received four continuous venovenous hemodialysis circuits with antico... περισσότερα »
Injuries to the head and neck in Homer’s Odyssey
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Re: Stathopoulos et al. Injuries to the head and neck in Homer’s Odyssey: We read with great interest the paper Injuries to the head and neck in Homer’s Odyssey by Stathopoulos et al, which provides valuable information about this type of trauma.1 Although Konsolaki et al had briefly described two cranial injuries in the Odyssey, […]
Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences: The purpose of this study was to compare medication-related osteonecrosis of the jaw (MRONJ) with osteoradionecrosis (ORN). Group 1 comprised 74 MRONJ patients (93 lesions) and group 2 comprised 59 ORN patients (69 lesions). Patient characteristics, clinical presentation of the lesions, the presence of complications, […]
Investigating the Voce Faringea: Physiological and Acoustic Characteristics of the Bel Canto Tenor’s Forgotten Singing Practice
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Investigating the Voce Faringea: Physiological and Acoustic Characteristics of the Bel Canto Tenor’s Forgotten Singing Practice: Several historical sources from the first half of the 19th century mention a distinct third register mechanism particular to tenor voices of that period. This so-called voce faringea—often described as an “intermediate” register—is a virtually forgotten historical singing practice […]
Soul and Musical Theater: A Comparison of Two Vocal Styles
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Soul and Musical Theater: A Comparison of Two Vocal Styles: The phonatory and resonatory characteristics of nonclassical styles of singing have been rarely analyzed in voice research. Six professional singers volunteered to sing excerpts from two songs pertaining to the musical theater and to the soul styles of singing. Voice source parameters and formant frequencies […]
Values of SP-A protein in the nasal mucosa
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Values of SP-A protein in the nasal mucosa: Abstract The paranasal sinus epithelium is exposed to the environment and therefore to a variety of biological, chemical and mechanical insults. Surfactant protein A (SP-A) is a 34–36 kD pulmonary surfactant-associated protein that appears to play an important role in mammalian first-line host defence. Recent studies have reported the possibility of local […]
Pathogenese und Molekularpathologie des Vestibularisschwannoms
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Pathogenese und Molekularpathologie des Vestibularisschwannoms: Zusammenfassung Schwannome sind Tumoren der Nervenscheide, die sich von den Schwann-Zellen herleiten. Am häufigsten treten sie am VIII. Hirnnerv (Vestibularisschwannome) auf. Histologisch finden sich mäßig zelldichte Spindelzelltumoren mit Ausbildung von Antoni-A- und -B-Regionen sowie Verocay-Körperchen. Eine maligne Entartung ist sehr selten. Ursächlich ist die Inaktivierung von Merlin (Schwannomin), dem Genprodukt […]
When alarm bells ring: emergency tinnitus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
When alarm bells ring: emergency tinnitus: OBJECTIVE: The aim of this study is to develop a diagnostic-therapeutic algorithm for those suffering from tinnitus who seek emergency aid. MATERIALS AND METHODS: A literature review has been performed on articles from the last 30 years. RESULTS: It is important to activate medical or surgical diagnostic and therapeutic […]
Insights on different analysis techniques in the monothermal and bithermal caloric test – which parameter should we use to quantify vestibular function?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Insights on different analysis techniques in the monothermal and bithermal caloric test – which parameter should we use to quantify vestibular function?: 10.1080/14992027.2016.1204668<br>Paul Radomskij Abstract Objective: To investigate the use of maximum slow component velocity (MSCV) and time-constant duration (TCd) of elicited nystagmus in quantifying the caloric response and to assess the efficacy of these […]
A review of the perceptual effects of hearing loss for frequencies above 3 kHz
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
A review of the perceptual effects of hearing loss for frequencies above 3 kHz: 10.1080/14992027.2016.1204565<br>Brian C. J. Moore Abstract Background: Hearing loss caused by exposure to intense sounds usually has its greatest effects on audiometric thresholds at 4 and 6 kHz. However, in several countries compensation for occupational noise-induced hearing loss is calculated using the average of […]
Hearing protector fit testing with off-shore oil-rig inspectors in Louisiana and Texas
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Hearing protector fit testing with off-shore oil-rig inspectors in Louisiana and Texas: 10.1080/14992027.2016.1204470<br>William J. Murphy Abstract Objective: This field study aimed to assess the noise reduction of hearing protection for individual workers, demonstrate the effectiveness of training on the level of protection achieved, and measure the time required to implement hearing protector fit testing in […]
Editorial Board
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 31 δευτερόλεπτα
[image: alertIcon.gif] Publication date: June 2016 *Source:*Artificial Intelligence in Medicine, Volume 70 from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/29LHdS2 via IFTTT
Evaluation of the Antioxidative, Antibacterial, and Anti-Inflammatory Effects of the Aloe Fermentation Supernatant Containing Lactobacillus plantarum HM218749.1
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 32 δευτερόλεπτα
Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacillus plantarum HM218749.1 had very strong scavenging capacities of the DPPH (86%), (85%), (76%), and chelation (82%) and reducing powers (242.5 mg/L), and the inhibition zones for Salmonella typhimurium, Salmonella enteritidis, Shigella flexneri, Escherichia coli, Liste... περισσότερα »
Age-related characteristics of risky decision-making and progressive expectation formation
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 32 δευτερόλεπτα
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Zsófia Kardos, Andrea Kóbor, Ádám Takács, Brigitta Tóth, Roland Boha, Bálint File, Márk Molnár During daily encounters, it is inevitable that people take risks. Investigating the sequential processing of risk hazards involve expectation formation about outcome contingencies. The present study aimed to explore risk behavior and its neural correlates in sequences of decision making, particularly in old age, which represents a critical period regarding risk-taking propensi... περισσότερα »
Forelimb training drives transient map reorganization in ipsilateral motor cortex
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 32 δευτερόλεπτα
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): David T. Pruitt, Ariel N. Schmid, Tanya T. Danaphongse, Kate E. Flanagan, Robert A. Morrison, Michael P. Kilgard, Robert L. Rennaker, Seth A. Hays Skilled motor training results in reorganization of contralateral motor cortex movement representations. The ipsilateral motor cortex is believed to play a role in skilled motor control, but little is known about how training influences reorganization of ipsilateral motor representations of the trained limb. To determine whe... περισσότερα »
Cortico-striato-thalamo-cortical circuit abnormalities in obsessive-compulsive disorder: A voxel-based morphometric and fMRI study of the whole brain
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 32 δευτερόλεπτα
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Wenxin Tang, Qifeng Zhu, Xiangyang Gong, Cheng Zhu, Yiquan Wang, Shulin Chen The primary aim of this study was to identify structural and functional abnormalities in the brains of obsessive-compulsive disorder (OCD) patients. Another aim was to assess the effect of serotonin selective reuptake inhibitors (SSRIs) on brain structure of OCD patients. All subjects underwent brain magnetic resonance imaging (MRI) and resting functional MRI (fMRI). High-resolution three-dime... περισσότερα »
Involvement of ventral tegmental area ionotropic glutamate receptors in the expression of ethanol-induced conditioned place preference
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 32 δευτερόλεπτα
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Melanie M. Pina, Christopher L. Cunningham The ventral tegmental area (VTA) is a well-established neural substrate of reward-related processes. Activity within this structure is increased by the primary and conditioned rewarding effects of abused drugs and its engagement is heavily reliant on excitatory input from structures upstream. In the case of drug seeking, it is thought that exposure to drug-associated cues engages glutamatergic VTA afferents that signal directly... περισσότερα »
Role of ventral pallidal D2 dopamine receptors in the consolidation of spatial memory
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 32 δευτερόλεπτα
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): László Péczely, Tamás Ollmann, Kristóf László, Anita Kovács, Rita Gálosi, Erika Kertes, Olga Zagorácz, Veronika Kállai, Zoltán Karádi, László Lénárd The role of dopamine (DA) receptors in spatial memory consolidation has been demonstrated in numerous brain regions, among others in the nucleus accumbens which innervates the ventral pallidum (VP). The VP contains both D1 and D2 DA receptors. We have recently shown that the VP D1 DA receptor activation facilitates consoli... περισσότερα »
D1- and D2-like dopamine receptors in the CA1 region of the hippocampus are involved in the acquisition and reinstatement of morphine-induced conditioned place preference
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 32 δευτερόλεπτα
Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Nasim Assar, Dorna Mahmoudi, Ali Farhoudian, Mohammad Hasan Farhadi, Zahra Fatahi, Abbas Haghparast The hippocampus plays a vital role in processing contextual memories and reward related learning tasks, such as conditioned place preference (CPP). Among the neurotransmitters in the hippocampus, dopamine is deeply involved in reward-related processes. This study assessed the role of D1- and D2-like dopamine receptors within the CA1 region of the hippocampus in the acquisition and reinstatement... περισσότερα »
The effects of spinal anesthesia on auditory function in pediatric patients
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
The effects of spinal anesthesia on auditory function in pediatric patients: Persistent or transient hearing loss (HL) is a less-recognized complication of spinal anesthesia (SA) in the pediatric population, although it has been previously reported in adults. The primary aim of this study was to investigate the effects of SA on auditory function in the… Continue reading The effects of spinal anesthesia on auditory function in pediatric patients
A new approach to nasoseptal fractures: Submucosal endoscopically assisted septoplasty and closed nasal reduction
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
A new approach to nasoseptal fractures: Submucosal endoscopically assisted septoplasty and closed nasal reduction: Nasal bone fracture is the most common among facial bone fractures. The prevalence of concomitant septal and nasal bone fractures fluctuates between 34% and 96.2%. An adequate management of such fractures is essential to prevent complications such as post-traumatic nasal obstruction… Continue reading A new approach to nasoseptal fractures: Submucosal endoscopically assisted septoplasty and closed nasal reduction
Injuries to the head and neck in Homer’s Odyssey
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
Re: Stathopoulos et al. Injuries to the head and neck in Homer’s Odyssey: We read with great interest the paper Injuries to the head and neck in Homer’s Odyssey by Stathopoulos et al, which provides valuable information about this type of trauma.1 Although Konsolaki et al had briefly described two cranial injuries in the Odyssey,… Continue reading Injuries to the head and neck in Homer’s Odyssey
Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences: The purpose of this study was to compare medication-related osteonecrosis of the jaw (MRONJ) with osteoradionecrosis (ORN). Group 1 comprised 74 MRONJ patients (93 lesions) and group 2 comprised 59 ORN patients (69 lesions). Patient characteristics, clinical presentation of the lesions, the presence of complications,… Continue reading Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences
Investigating the Voce Faringea: Physiological and Acoustic Characteristics of the Bel Canto Tenor’s Forgotten Singing Practice
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
Investigating the Voce Faringea: Physiological and Acoustic Characteristics of the Bel Canto Tenor’s Forgotten Singing Practice: Several historical sources from the first half of the 19th century mention a distinct third register mechanism particular to tenor voices of that period. This so-called voce faringea—often described as an “intermediate” register—is a virtually forgotten historical singing practice… Continue reading Investigating the Voce Faringea: Physiological and Acoustic Characteristics of the Bel Canto Tenor’s Forgotten Singing Practice
Soul and Musical Theater: A Comparison of Two Vocal Styles
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
Soul and Musical Theater: A Comparison of Two Vocal Styles: The phonatory and resonatory characteristics of nonclassical styles of singing have been rarely analyzed in voice research. Six professional singers volunteered to sing excerpts from two songs pertaining to the musical theater and to the soul styles of singing. Voice source parameters and formant frequencies… Continue reading Soul and Musical Theater: A Comparison of Two Vocal Styles
Values of SP-A protein in the nasal mucosa
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
Values of SP-A protein in the nasal mucosa: Abstract The paranasal sinus epithelium is exposed to the environment and therefore to a variety of biological, chemical and mechanical insults. Surfactant protein A (SP-A) is a 34–36 kD pulmonary surfactant-associated protein that appears to play an important role in mammalian first-line host defence. Recent studies have… Continue reading Values of SP-A protein in the nasal mucosa
Pathogenese und Molekularpathologie des Vestibularisschwannoms
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
Pathogenese und Molekularpathologie des Vestibularisschwannoms: Zusammenfassung Schwannome sind Tumoren der Nervenscheide, die sich von den Schwann-Zellen herleiten. Am häufigsten treten sie am VIII. Hirnnerv (Vestibularisschwannome) auf. Histologisch finden sich mäßig zelldichte Spindelzelltumoren mit Ausbildung von Antoni-A- und -B-Regionen sowie Verocay-Körperchen. Eine maligne Entartung ist sehr selten. Ursächlich ist die Inaktivierung von Merlin (Schwannomin), dem Genprodukt… Continue reading Pathogenese und Molekularpathologie des Vestibularisschwannoms
Strategies for Teachers to Manage Stuttering in the Classroom: A Call for Research
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
Strategies for Teachers to Manage Stuttering in the Classroom: A Call for Research: Purpose This clinical focus article highlights the need for future research involving ways to assist children who stutter in the classroom. Method The 4 most commonly recommended strategies for teachers were found via searches of electronic databases and personal libraries of the… Continue reading Strategies for Teachers to Manage Stuttering in the Classroom: A Call for Research
The Role of Socioeconomic Status in the Narrative Story Retells of School-Aged English Language Learners
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 33 δευτερόλεπτα
The Role of Socioeconomic Status in the Narrative Story Retells of School-Aged English Language Learners: Purpose We examined the relationship between maternal level of education as an index of socioeconomic status (SES) on the narrative story retells of school-aged children who are English language learners (ELLs) to guide interpretation of results. Method Using data available… Continue reading The Role of Socioeconomic Status in the Narrative Story Retells of School-Aged English Language Learners
Effect of Chlorhexidine Bathing Every Other Day on Prevention of Hospital-Acquired Infections in the Surgical ICU: A Single-Center, Randomized Controlled Trial.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Objective: To test the hypothesis that compared with daily soap and water bathing, 2% chlorhexidine gluconate bathing every other day for up to 28 days decreases the risk of hospital-acquired catheter-associated urinary tract infection, ventilator-associated pneumonia, incisional surgical site infection, and primary bloodstream infection in surgical ICU patients. Design: This was a single-center, pragmatic, randomized trial. Patients and clinicians were aware of treatment-group assignment; investigators who determined outcomes were blinded. Setting: Twenty-four-bed surgical ICU at a... περισσότερα »
Global Trends in Extracorporeal Membranous Oxygenation Use and Survival of Patients With Influenza-Associated Illness.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Objectives: To determine the overall use of extracorporeal membranous oxygenation for influenza-associated illness and describe risk factors associated with mortality in these patients. Design: Retrospective multicenter cohort analysis. Setting: The international Extracorporeal Life Support Organization database was queried for patients with influenza-associated illness on extracorporeal membranous oxygenation from 1992 to 2014. Patients: In total, 1,654 patients with influenza-associated illness on extracorporeal membranous oxygenation. Interventions: None. Measurements and Main Re... περισσότερα »
A More Rapid, Rapid Response.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Objectives: Critical care physicians' standard for arrival to a rapid response team activation is 10 minutes or less at this institution. This study proposes that a FaceTime (Apple, Cupertino, CA) video call between the staff at the bedside and the critical care physician will allow the implementation of potentially life-saving therapies earlier than the current average response (4.5 min). Design: Prospective cohort study. Setting: Freestanding, tertiary-care children's hospital. Patients: Pediatric patients ages 0-17. Interventions: Six units were chosen as matched pairs. In the te... περισσότερα »
Circuit Lifetime With Citrate Versus Heparin in Pediatric Continuous Venovenous Hemodialysis.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Objectives: To determine if there is a difference between regional citrate and global heparinized anticoagulation on circuit lifetimes during continuous venovenous hemodialysis in children. Design: Prospective "cross-over" trial. Setting: PICU, Department of Pediatrics, University Hospital Ostrava. Patients: Children 0-18 years old. Interventions: From 2009 to 2014, 63 eligible children (age, 89.24 +/- 62.9 mo; weight, 30.37 +/- 20.62 kg) received at least 24 hours of continuous venovenous hemodialysis. Each child received four continuous venovenous hemodialysis circuits with antico... περισσότερα »
Advantages of Calvarial Vault Distraction for the Late Treatment of Cephalocranial Disproportion.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Advantages of Calvarial Vault Distraction for the Late Treatment of Cephalocranial Disproportion.: Purpose: Cephalocranial disproportion is a symptomatic condition related to a volume discrepancy between the calvarial vault and the brain. Traditional expansion techniques are unfavorable in older children due to inadequate dural ossification, lack of bone pliability, and limited future growth potential. The authors… Continue reading Advantages of Calvarial Vault Distraction for the Late Treatment of Cephalocranial Disproportion.
Vascularized Nasoseptal Flap for Medial Orbital Wall Reconstruction.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Vascularized Nasoseptal Flap for Medial Orbital Wall Reconstruction.: With the use and efficacy of the vascularized nasoseptal flap, its indications are also expanding. Due to its relative ease of harvesting and no significant impairment in the long-term sinonasal quality of life, the flap has been used for a number of other purposes apart from its… Continue reading Vascularized Nasoseptal Flap for Medial Orbital Wall Reconstruction.
Reconstruction of nasal defects: contemporary approaches.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Reconstruction of nasal defects: contemporary approaches.: Purpose of review: There are many well-established principles and surgical techniques for nasal reconstruction. The purpose of this study is to describe contemporary reconstruction of nasal defects. The unique anatomic features of the nose make this a challenging task. Although obtaining an optimal esthetic result is always the goal… Continue reading Reconstruction of nasal defects: contemporary approaches.
PubMed 17 July 2016
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates [Unusual dysphagia in IgG4-related disease]. 16 July 2016, 16:19:10 | Engelbarts M, Schad A, Matthias C [Unusual dysphagia in IgG4-related disease]. HNO. 2016 Jul 14; Authors: Engelbarts M, Schad A, Matthias C Abstract This article presents… Continue reading PubMed 17 July 2016
Activated Glia Increased the Level of Proinflammatory Cytokines in a Resiniferatoxin-Induced Neuropathic Pain Rat Model.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Background and Objectives: Administration of resiniferatoxin (RTX) can mimic the clinical symptoms of postherpetic neuralgia. However, it is unclear whether activated glia contribute to the pathogenesis of RTX-induced neuropathic pain; furthermore, the relationship between p38, N-methyl-D-aspartate receptor type 2B (NR2B) as well as proinflammatory cytokines and activated glia remains unknown. Methods: Intraperitoneal injection of RTX… Continue reading Activated Glia Increased the Level of Proinflammatory Cytokines in a Resiniferatoxin-Induced Neuropathic Pain Rat Model.
A Clinicopathologic Study of Lennert Lymphoma and Possible Prognostic Factors: The Importance of Follicular Helper T-cell Markers and the Association With Angioimmunoblastic T-cell Lymphoma.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Lennert lymphoma (LeL) is a variant of peripheral T-cell lymphoma, not otherwise specified. Few clinicopathologic studies have investigated LeL, which is a rare disease. Here, we analyzed the clinicopathologic features of 26 patients with LeL to identify potential prognostic factors. Neoplastic cells positive for CD4, CD8, CD4/CD8, TIA-1, and granzyme B were observed in 21… Continue reading A Clinicopathologic Study of Lennert Lymphoma and Possible Prognostic Factors: The Importance of Follicular Helper T-cell Markers and the Association With Angioimmunoblastic T-cell Lymphoma.
Classification of Extraovarian Implants in Patients With Ovarian Serous Borderline Tumors (Tumors of Low Malignant Potential) Based on Clinical Outcome.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
The classification of extraovarian disease into invasive and noninvasive implants predicts patient outcome in patients with high-stage ovarian serous borderline tumors (tumors of low malignant potential). However, the morphologic criteria used to classify implants vary between studies. To date, there has been no large-scale study with follow-up data comparing the prognostic significance of competing criteria.… Continue reading Classification of Extraovarian Implants in Patients With Ovarian Serous Borderline Tumors (Tumors of Low Malignant Potential) Based on Clinical Outcome.
Ectopic Hamartomatous Thymoma-New Insights Into a Challenging Entity: A Clinicopathologic and Immunohistochemical Study of 9 Cases.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Nine cases of ectopic hamartomatous thymoma are described. The patients were 5 men and 4 women aged 34 to 52 years (mean, 43 y). All patients presented with solitary lower neck masses ranging in size from 3.5 to 8.0 cm (mean, 5.4 cm). Grossly, the lesions were circumscribed and lobulated masses with a fleshy white… Continue reading Ectopic Hamartomatous Thymoma-New Insights Into a Challenging Entity: A Clinicopathologic and Immunohistochemical Study of 9 Cases.
Tumor Necrosis Adds Prognostically Significant Information to Grade in Clear Cell Renal Cell Carcinoma: A Study of 842 Consecutive Cases From a Single Institution.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
Tumor necrosis has been shown to be an independent predictor of adverse outcome in renal cell carcinoma. A modification of the International Society of Urological Pathology (ISUP) grading system for renal cell carcinomas has recently been proposed, which incorporates the presence of tumor necrosis into grade. The investigators proposing this system found that necrosis added… Continue reading Tumor Necrosis Adds Prognostically Significant Information to Grade in Clear Cell Renal Cell Carcinoma: A Study of 842 Consecutive Cases From a Single Institution.
BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 54 δευτερόλεπτα
With the advent of next-generation sequencing, an increasing number of novel gene fusions and other abnormalities have emerged recently in the spectrum of EWSR1-negative small blue round cell tumors (SBRCTs). In this regard, a subset of SBRCTs harboring either BCOR gene fusions (BCOR-CCNB3, BCOR-MAML3), BCOR internal tandem duplications (ITD), or YWHAE-NUTM2B share a transcriptional signature… Continue reading BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities.
Efficacy of Topical Timolol as Primary Monotherapy in Cutaneous Facial Infantile Hemangiomas.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Recent studies have shown that infantile hemangiomas (IHs) undergo a rapid growth phase between 5.5 and 7.5 weeks of life and do not usually proliferate beyond 6 months; growth thereafter is usually proportionate to the child’s growth. This review assesses the evidence for topical timolol as primary monotherapy for cutaneous facial IHs before 12 months […]
Suppurative Cervical Tuberculous Lymphadenitis Mimicking a Metastatic Neck Mass.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Tuberculosis is an important public’s health problem in developing countries. Although tuberculosis is commonly found in lungs, it could also be found in lymph nodes, mouth, tonsils, tounge, nose, epiglottis, larynx, and pharynx of head-neck region. The most common form of extrapulmonary tuberculosis placed outside the lungs is tuberculous lymphadenitis. Tuberculosis lymphadenitis is the most […]
The Importance of Soft Triangle in Rhinoplasty.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The soft triangle is a basic, yet delicate and vulnerable, subunit of the nose that is under-rated both academically and surgically. The soft triangle is located at the apex of the nostril, at the point where the dermis is in direct contact with dermis that contains no intervening subcutaneous tissue and it may be unintentionally […]
A Reduction Technique for a Depressed and Impacted Nasomaxillary Buttress Fracture.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The aim of this study is to introduce an easy method of reducing the depressed and impacted segment in a nasomaxillary buttress fracture. Through the gingiva-labial vestibular incision, the fracture segments were exposed. A blunt end of the Cottle elevator was inserted to the cleft of the fracture segments. An upward and lateral force was […]
Activated Glia Increased the Level of Proinflammatory Cytokines in a Resiniferatoxin-Induced Neuropathic Pain Rat Model.
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα
Background and Objectives: Administration of resiniferatoxin (RTX) can mimic the clinical symptoms of postherpetic neuralgia. However, it is unclear whether activated glia contribute to the pathogenesis of RTX-induced neuropathic pain; furthermore, the relationship between p38, N-methyl-D-aspartate receptor type 2B (NR2B) as well as proinflammatory cytokines and activated glia remains unknown. Methods: Intraperitoneal injection of RTX was performed to induce neuropathic pain in rats. Mechanical allodynia and thermal hyperalgesia were assessed by von Frey filaments and a radiant heat... περισσότερα »
A Clinicopathologic Study of Lennert Lymphoma and Possible Prognostic Factors: The Importance of Follicular Helper T-cell Markers and the Association With Angioimmunoblastic T-cell Lymphoma.
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Lennert lymphoma (LeL) is a variant of peripheral T-cell lymphoma, not otherwise specified. Few clinicopathologic studies have investigated LeL, which is a rare disease. Here, we analyzed the clinicopathologic features of 26 patients with LeL to identify potential prognostic factors. Neoplastic cells positive for CD4, CD8, CD4/CD8, TIA-1, and granzyme B were observed in 21 (80.8%), 4 (15.4%), 1 (3.8%), 4 (15.3%), and 0 (0.0%) patients, respectively. Regarding follicular helper T-cell (TFH) markers, neoplastic cells positive for programmed cell death-1 (PD-1), CXCL13, CD10, and BCL6 ... περισσότερα »
Classification of Extraovarian Implants in Patients With Ovarian Serous Borderline Tumors (Tumors of Low Malignant Potential) Based on Clinical Outcome.
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
[image: wk-health-logo.gif] The classification of extraovarian disease into invasive and noninvasive implants predicts patient outcome in patients with high-stage ovarian serous borderline tumors (tumors of low malignant potential). However, the morphologic criteria used to classify implants vary between studies. To date, there has been no large-scale study with follow-up data comparing the prognostic significance of competing criteria. Peritoneal and/or lymph node implants from 181 patients with high-stage serous borderline tumors were evaluated independently by 3 pathologists for... περισσότερα »
Ectopic Hamartomatous Thymoma-New Insights Into a Challenging Entity: A Clinicopathologic and Immunohistochemical Study of 9 Cases.
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
[image: wk-health-logo.gif] Nine cases of ectopic hamartomatous thymoma are described. The patients were 5 men and 4 women aged 34 to 52 years (mean, 43 y). All patients presented with solitary lower neck masses ranging in size from 3.5 to 8.0 cm (mean, 5.4 cm). Grossly, the lesions were circumscribed and lobulated masses with a fleshy white cut surface; cystic changes were identified in 3 cases. Histologically, the tumors were composed of varying proportions of spindle cells arranged in fascicles, mature adipose tissue, and an epithelial component composed of squamoid elements and... περισσότερα »
Tumor Necrosis Adds Prognostically Significant Information to Grade in Clear Cell Renal Cell Carcinoma: A Study of 842 Consecutive Cases From a Single Institution.
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
[image: wk-health-logo.gif] Tumor necrosis has been shown to be an independent predictor of adverse outcome in renal cell carcinoma. A modification of the International Society of Urological Pathology (ISUP) grading system for renal cell carcinomas has recently been proposed, which incorporates the presence of tumor necrosis into grade. The investigators proposing this system found that necrosis added significant prognostic information to ISUP grade. We attempted to describe our experience with the effect of tumor necrosis in relationship to nuclear grade by reviewing the slides fr... περισσότερα »
BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities.
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
With the advent of next-generation sequencing, an increasing number of novel gene fusions and other abnormalities have emerged recently in the spectrum of EWSR1-negative small blue round cell tumors (SBRCTs). In this regard, a subset of SBRCTs harboring either BCOR gene fusions (BCOR-CCNB3, BCOR-MAML3), BCOR internal tandem duplications (ITD), or YWHAE-NUTM2B share a transcriptional signature including high BCOR mRNA expression, as well as similar histologic features. Furthermore, other tumors such as clear cell sarcoma of kidney (CCSK) and primitive myxoid mesenchymal tumor of infan... περισσότερα »
A Clinicopathologic Study of Lennert Lymphoma and Possible Prognostic Factors: The Importance of Follicular Helper T-cell Markers and the Association With Angioimmunoblastic T-cell Lymphoma.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Lennert lymphoma (LeL) is a variant of peripheral T-cell lymphoma, not otherwise specified. Few clinicopathologic studies have investigated LeL, which is a rare disease. Here, we analyzed the clinicopathologic features of 26 patients with LeL to identify potential prognostic factors. Neoplastic cells positive for CD4, CD8, CD4/CD8, TIA-1, and granzyme B were observed in 21 (80.8%), 4 (15.4%), 1 (3.8%), 4 (15.3%), and 0 (0.0%) patients, respectively. Regarding follicular helper T-cell (TFH) markers, neoplastic cells positive for programmed cell death-1 (PD-1), CXCL13, CD10, and BCL6 ... περισσότερα »
Classification of Extraovarian Implants in Patients With Ovarian Serous Borderline Tumors (Tumors of Low Malignant Potential) Based on Clinical Outcome.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: wk-health-logo.gif] The classification of extraovarian disease into invasive and noninvasive implants predicts patient outcome in patients with high-stage ovarian serous borderline tumors (tumors of low malignant potential). However, the morphologic criteria used to classify implants vary between studies. To date, there has been no large-scale study with follow-up data comparing the prognostic significance of competing criteria. Peritoneal and/or lymph node implants from 181 patients with high-stage serous borderline tumors were evaluated independently by 3 pathologists for... περισσότερα »
Ectopic Hamartomatous Thymoma-New Insights Into a Challenging Entity: A Clinicopathologic and Immunohistochemical Study of 9 Cases.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: wk-health-logo.gif] Nine cases of ectopic hamartomatous thymoma are described. The patients were 5 men and 4 women aged 34 to 52 years (mean, 43 y). All patients presented with solitary lower neck masses ranging in size from 3.5 to 8.0 cm (mean, 5.4 cm). Grossly, the lesions were circumscribed and lobulated masses with a fleshy white cut surface; cystic changes were identified in 3 cases. Histologically, the tumors were composed of varying proportions of spindle cells arranged in fascicles, mature adipose tissue, and an epithelial component composed of squamoid elements and... περισσότερα »
Tumor Necrosis Adds Prognostically Significant Information to Grade in Clear Cell Renal Cell Carcinoma: A Study of 842 Consecutive Cases From a Single Institution.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: wk-health-logo.gif] Tumor necrosis has been shown to be an independent predictor of adverse outcome in renal cell carcinoma. A modification of the International Society of Urological Pathology (ISUP) grading system for renal cell carcinomas has recently been proposed, which incorporates the presence of tumor necrosis into grade. The investigators proposing this system found that necrosis added significant prognostic information to ISUP grade. We attempted to describe our experience with the effect of tumor necrosis in relationship to nuclear grade by reviewing the slides fr... περισσότερα »
BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
With the advent of next-generation sequencing, an increasing number of novel gene fusions and other abnormalities have emerged recently in the spectrum of EWSR1-negative small blue round cell tumors (SBRCTs). In this regard, a subset of SBRCTs harboring either BCOR gene fusions (BCOR-CCNB3, BCOR-MAML3), BCOR internal tandem duplications (ITD), or YWHAE-NUTM2B share a transcriptional signature including high BCOR mRNA expression, as well as similar histologic features. Furthermore, other tumors such as clear cell sarcoma of kidney (CCSK) and primitive myxoid mesenchymal tumor of infan... περισσότερα »
First report of severe acute otitis media caused by Campylobacter rectus and review of the literature
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 28 June 2016 Source:Journal of Infection and Chemotherapy Author(s): Risako Kakuta, Hiroshi Hidaka, Hisakazu Yano, Michiko Okamoto, Daiki Ozawa, Shiro Endo, Mitsuo Kaku, Yukio Katori Campylobacter rectus is a member of the human oral flora and is associated with periodontal disease. We report the first case of severe acute otitis media […]
Successful treatment of Bordetella bronchiseptica pneumonia by minocycline in anti-neutrophil cytoplasmic antibodies-associated vasculitis patient
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 11 July 2016 Source:Journal of Infection and Chemotherapy Author(s): Yuji Ito, Keiichi Uemura Bordetella bronchiseptica is a bacterial pathogen usually isolated from animals and rarely causes human infections. There are, however, some reports that B. bronchiseptica causes human respiratory infections in immunocompromised patients or those with underlying respiratory diseases, although there […]
Adrenomedullin predicts high risk and culture positivity in children with solid tumors suffering from neutropenic fever
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 9 July 2016 Source:Journal of Infection and Chemotherapy Author(s): Vural Kesik, Erman Ataş, Yasemin Gülcan Kurt, Fevzi Nuri Aydın, Oğuzhan Babacan, Mustafa Gülgün, Nadir Korkmazer Aim of studyNeutropenic fever is a source of morbidity and mortality in children with cancer. It is not possible to detect the causative agent in cultures […]
Corrigendum to “depletion of the “gamma-type carbonic anhydrase-like” subunits of complex I affects central mitochondrial metabolism in Arabidopsis thaliana” Biochim. Biophys. Acta 1857 (2016) 60–71
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Steffanie Fromm, Jennifer Göing, Christin Lorenz, Christoph Peterhänsel, Hans-Peter Braun from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ZuM7Y via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 16 July 2016 Source:Experimental Cell Research Author(s): G. Fianco, C. Cenci, D. Barilà Caspase-8 expression is lost in a small percentage of tumors suggesting that the retention of its functionality may positively contribute to tumour progression. Consistently, several non-apoptotic functions of Caspase-8 have been identified and Caspase-8 has been shown to […]
Inhibition of disheveled-2 resensitizes cisplatin-resistant lung cancer cells through down-regulating Wnt/β-catenin signaling
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 16 July 2016 Source:Experimental Cell Research Author(s): Ke Luo, Xiuhui Gu, Jing Liu, Guodan Zeng, Liaotian Peng, Houyi Huang, Mengju Jiang, Ping Yang, Minhui Li, Yuhan Yang, Yuanyuan Wang, Quekun Peng, Li Zhu, Kun Zhang Cisplatin (CDDP) is currently recommended as the front-line chemotherapeutic agent for lung cancer. However, the resistance […]
Rabies virus matrix protein induces apoptosis by targeting mitochondria
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 15 July 2016 Source:Experimental Cell Research Author(s): Jie Zan, Juan Liu, Jian-Wei Zhou, Hai-Long Wang, Kai-Kun Mo, Yan Yan, Yun-Bin Xu, Min Liao, Shuo Su, Rong-Liang Hu, Ji-Yong Zhou Apoptosis, as an innate antiviral defense, not only functions to limit viral replication by eliminating infected cells, but also contribute to viral […]
miR-125b targets DNMT3b and mediates p53 DNA methylation involving in the vascular smooth muscle cells proliferation induced by homocysteine
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 15 July 2016 Source:Experimental Cell Research Author(s): ChengJian Cao, HuiPing Zhang, Li Zhao, Longxia Zhou, Minghao Zhang, Hua Xu, Xuebo Han, Guizhong Li, Xiaoling Yang, YiDeng Jiang MicroRNAs (miRNAs) are short non-coding RNA and play crucial roles in a wide array of biological processes, including cell proliferation, differentiation and apoptosis. Our […]
Is Swimming Safe in Areas With the Freshwater ‘Brain-Eating’ Amoeba? – Napa Valley Register
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Napa Valley Register Is Swimming Safe in Areas With the Freshwater ‘Brain-Eating’ Amoeba? Napa Valley Register While most cases occur from a person jumping into a lake or river, the infection also can occur during a sinus rinse using a neti pot filled with tap water, Sood added. People should always use water labeled «distilled» […]
Is swimming safe in areas with ‘brain-eating’ amoeba? – UPI.com
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
UPI.com Is swimming safe in areas with ‘brain-eating’ amoeba? UPI.com While most cases occur from a person jumping into a lake or river, the infection also can occur during a sinus rinse using a neti pot filled with tap water, Sood added. People should always use water labeled «distilled» or «sterile» in a neti pot […]
Organisers hail ‘fantastic day’ at annual Croydon race to battle cancer – Your Local Guardian
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Your Local Guardian Organisers hail ‘fantastic day’ at annual Croydon race to battle cancer Your Local Guardian Among those running on Sunday was guest of honour Angie Kopka, who was 12 weeks pregnant with her second child Alex when she was diagnosed with tongue cancer in 2011. Mrs Kopka, 38, was referred to Croydon University […]
Da sinnssykeloven var 86 år
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
I et nummer av Tidsskriftet i 1934 er det et innlegg av den kjente «sinnssykelæge» Henrik Dedichen. På dette tidspunkt i livet har han bare igjen å skrive sitt «psykiatriske testamente». from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FjWCd via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Clinical Outcomes of Ruptured Periorbital and Orbital Dermoid Cysts.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Purpose: To evaluate the clinical outcomes of ruptured dermoid cysts. Methods: A multicenter, retrospective study of all cases of periorbital and orbital dermoid cysts with histopathological evidence of rupture, including those with clinical rupture, was performed over a 10-year period. Demographics and clinical outcomes of ruptured dermoid cysts were recorded. Persistent inflammation was defined as […]
Reconstruction of nasal defects: contemporary approaches.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Purpose of review: There are many well-established principles and surgical techniques for nasal reconstruction. The purpose of this study is to describe contemporary reconstruction of nasal defects. The unique anatomic features of the nose make this a challenging task. Although obtaining an optimal esthetic result is always the goal of reconstruction, maintenance and restoration of nasal function are of equal importance. Recent findings: The first step of nasal reconstruction is a thoughtful analysis of the defect. The best surgical option will provide the patient with an excellent... περισσότερα »
Advantages of Calvarial Vault Distraction for the Late Treatment of Cephalocranial Disproportion.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Purpose: Cephalocranial disproportion is a symptomatic condition related to a volume discrepancy between the calvarial vault and the brain. Traditional expansion techniques are unfavorable in older children due to inadequate dural ossification, lack of bone pliability, and limited future growth potential. The authors review their experience using distraction to close bone defects in this setting. Methods: A retrospective analysis was performed of all patients treated using distraction in this setting by a single surgeon. Demographic and outcomes data were collected. The efficacy o... περισσότερα »
Vascularized Nasoseptal Flap for Medial Orbital Wall Reconstruction.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
With the use and efficacy of the vascularized nasoseptal flap, its indications are also expanding. Due to its relative ease of harvesting and no significant impairment in the long-term sinonasal quality of life, the flap has been used for a number of other purposes apart from its originally proposed use in reconstruction of the anterior cranial fossa, sella, and the clivus. Its use may negate the need of another incision to obtain fat or fascia. The authors describe the case of a 47-year-old lady who underwent endoscopic excision of a medially placed orbital intraconal hemangioma ... περισσότερα »
Evidence for Use of Frontozygomaticus and Contralateral Eurion as Hand-Caliper Landmarks for Assessment of Deformational Plagiocephaly.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
The severity of deformational plagiocephaly is frequently measured by cranial vault asymmetry (CVA). Cranial vault asymmetry is a simple linear proxy for the three-dimensional deformity. Different anthropometric landmarks have been suggested as the endpoints of the cross-cranial diagonals that determine CVA. One promising albeit counterintuitive set of digital landmarks is the frontozygomaticus and contralateral eurion. The validity of nondigital caliper measures associated with the diagonals defined by the frontozygomaticus and contralateral eurions has not been tested. In this s... περισσότερα »
The Conservative Treatment of Pediatric Mandible Fracture With External Nasal Splint.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Introduction: The frequency of mandible fractures is relatively less in children compared with adults, but their treatment is significantly more challenging due to the concerns regarding mandible growth and the developing dentition. The authors have introduced a new way of closed reduction by using external nasal splints. Methods: In 3 patients aged between 4 and 6-year old with parasymphyseal and body fractures of mandible, fractures were reduced under general anesthesia and thermoplastic nasal splints were directly formed and trimmed to fit the lingual surface of mandible. Splin... περισσότερα »
Osteonevus of Nanta Presenting as Flesh-Colored Papule of Cheek Following Laser Ablation.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Osteonevus of Nanta is a melanocytic nevus displaying secondary ossification and carrying a potential for malignancy. A solitary occurrence is reported herein, presenting as a flesh-colored papule following laser ablation. A 56-year-old woman sought treatment for a minor papular growth of the cheek. This lesion had developed at the site of prior CO2 laser ablation done elsewhere to eradicate a pigmented nevus. The patient’s medical records and histopathology report were obtained after surgical excision. Histologically, a completely excised osteonevus of Nanta was evident, marked b... περισσότερα »
Improved Virtual Planning for Bimaxillary Orthognathic Surgery.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Conventional model surgery planning for bimaxillary orthognathic surgery can be laborious, time-consuming and may contain potential errors; hence three-dimensional (3D) virtual orthognathic planning has been proven to be an efficient, reliable, and cost-effective alternative. In this report, the 3D planning is described for a patient presenting with a Class III incisor relationship on a Skeletal III base with pan facial asymmetry complicated by reverse overjet and anterior open bite. A combined scan data of direct cone beam computer tomography and indirect dental scan were used in ... περισσότερα »
Reconstructive Surgery in Times of Conflict.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Background: Smile Train is a charitable organization that partners with and trains surgeons in developing countries to provide surgical care to patients with cleft lip/palate deformities. The organization supports surgeries in several countries that experience high levels of regional conflict and violence. Nigeria, a country where Smile Train is very active, has undergone numerous periods of extreme violence over the past 12 years. The purpose of the present study is to analyze how local violence and conflict have impacted the ability of surgeons partnered with Smile Train to prov... περισσότερα »
Bifid Facial Nerve Trunk: Anatomic and Surgical Considerations.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
The segment of the facial nerve (FN) between its emergence from the skull through the stylomastoid foramen and its bifurcation at the parotid area is referred to as the FN trunk (FNT). Injury to the facial nerve trunk is among the most undesirable outcomes following different otologic, plastic, maxillofacial, and neurosurgical procedures. These procedures frequently involve manipulation and isolation of this segment, and meticulous dissection should be practiced to avoid iatrogenic damage to the nerve. Identification and exposure of the FN trunk, however, may be difficult because ... περισσότερα »
Management of Zygomatic Fractures: A National Survey.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Introduction: Repair of zygomatic fractures can be classified into the early closed reduction or the more recent open reduction and rigid internal fixation (ORIF) methods. Surgical training and literature advocate ORIF, but the actual frequency of the different techniques in clinical practice is unknown. The purpose of this study was to determine the current trends in the management of zygomatic fractures among US surgeons and elucidate their influences. Methods: A 10-question survey was developed and distributed to over 16,000 practicing US facial trauma surgeons, including plast... περισσότερα »
Detailed Anatomical Analysis of the Sphenoid Sinus and Sphenoid Sinus Ostium by Cone-Beam Computed Tomography.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
The aim of this study is the evaluation of the anatomical structures of sphenoid sinus ostium used as a reference point for transsphenoidal surgery by cone beam computed tomography. The authors’ study was performed using the cone-beam computed tomography images of 16 to 82-year old 200 (112 female, 88 male) patients (Newton 5G, Verona, Italy). Septum deviation of sphenoid sinus and the distance between 2 ostia were evaluated by coronal and axial sections, respectively. Pneumatization degree of sphenoid sinus, diameter of sphenoid sinus ostium, and distance lower edge of superior t... περισσότερα »
Multidisciplinary Team Treatment of Penetrating Head and Neck Trauma.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Penetrating head and neck trauma could cause significant mortality because of many important structures located in the brain and neck. Although high-velocity penetrating brain injury is often reported, reports of low-velocity, combined head and neck penetrating injury are rare. Hereby, the authors present a case of an old man who had encountered a serious accident, a 29-cm iron fork penetrated into his neck, through the skull base and into brain. After treatment by multidisciplinary team, the patient was in rehabilitation. The multidisciplinary team assists rapid diagnosis and tre... περισσότερα »
Clinical Evaluation of an Unsintered Hydroxyapatite/Poly-L-Lactide Osteoconductive Composite Device for the Internal Fixation of Maxillofacial Fractures.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Introduction: OSTEOTRANS MX (Takiron Co, Ltd, Osaka, Japan) is a resorbable osteosynthetic material composed of an unsintered hydroxyapatite/poly-l-lactide composite, and its osteoconductive capacity has been documented. The authors here report their clinical experience using OSTEOTRANS MX. Methods: The authors treated 35 patients (19 men, 16 women; age, 14-88 years; mean +/- standard deviation, 38.4 +/- 19.9 years) with maxillofacial fractures. The authors used standard surgery to stabilize fractures in all patients, fitting resorbable plates (thickness, 1.0 or 1.4 mm) and screws... περισσότερα »
Primary Intraosseous Hemangioma of the Orbital Roof: A Pitfall of Surgery.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
A primary intraosseous hemangioma (IOH) of the orbital bone is extremely rare. The preferred method of treatment for IOH is total surgical excision with reconstruction. Herein, the authors describe a patient with an orbital roof IOH and the unexpected complications of ptosis and deteriorated exophthalmos. These findings showed that the total surgical excision and subsequent reconstruction provided adequate decompression and prevented further ocular complications from the orbital wall defect. © 2016 by Mutaz B. Habal, MD. http://ift.tt/29ZsNAr
Sarcoidosis Nodules on the Lateral Nasal Osteotomy Lines.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Sarcoidosis is a multisystem inflammatory disease that manifests as noncaseating granulomas, commonly in the lungs and intrathoracic lymph nodes. Subcutaneous manifestations of sarcoidosis that are caused by granulomas are referred to as specific for sarcoidosis, whereas other lesions are considered nonspecific. The authors present “sarcoidosis nodule formation on the lateral nasal osteotomy lines” in a sarcoidosis patient undergoing rhinoplasty surgery as a rare patient. Level of Evidence: V © 2016 by Mutaz B. Habal, MD. http://ift.tt/29Zsw0J
Efficacy of Topical Timolol as Primary Monotherapy in Cutaneous Facial Infantile Hemangiomas.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Recent studies have shown that infantile hemangiomas (IHs) undergo a rapid growth phase between 5.5 and 7.5 weeks of life and do not usually proliferate beyond 6 months; growth thereafter is usually proportionate to the child’s growth. This review assesses the evidence for topical timolol as primary monotherapy for cutaneous facial IHs before 12 months of age, and to determine the differences in outcome between early (before 6 months) and late initiation (after 6 months) of timolol. A review of English language articles published up to November 2015 was performed using selected ke... περισσότερα »
Midfacial Protraction With Skeletal Anchorage After Pterygomaxillary Separation.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
The present article reports the treatment of a 7-year-old girl with maxillary hypoplasia associated with multiple tooth agenesis through maxillary protraction with skeletal anchorage and pterygomaxillary separation. Two titanium mini-plates were placed in the lateral region of the nasal cavity and used as anchorage for maxillary protraction with a reverse-pull facemask. Pterygomaxillary separation was also performed to enhance the effects of maxillary protraction. One week after surgery, 300 g of force was applied on each side to protract the maxilla. Active treatment time was 4 m... περισσότερα »
Suppurative Cervical Tuberculous Lymphadenitis Mimicking a Metastatic Neck Mass.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Tuberculosis is an important public’s health problem in developing countries. Although tuberculosis is commonly found in lungs, it could also be found in lymph nodes, mouth, tonsils, tounge, nose, epiglottis, larynx, and pharynx of head-neck region. The most common form of extrapulmonary tuberculosis placed outside the lungs is tuberculous lymphadenitis. Tuberculosis lymphadenitis is the most commonly seen form of the extrapulmoner tuberculosis and usually invades the lymph nodules of the cervical region. An adult patient with tuberculous lymphadenitis has been presented within th... περισσότερα »
The Importance of Soft Triangle in Rhinoplasty.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
The soft triangle is a basic, yet delicate and vulnerable, subunit of the nose that is under-rated both academically and surgically. The soft triangle is located at the apex of the nostril, at the point where the dermis is in direct contact with dermis that contains no intervening subcutaneous tissue and it may be unintentionally harmed during rhinoplasty. The authors suggest using a modified incision and closure and filling with significantly or severely crushed cartilage to prevent notching and to provide support for the soft triangle. The more the authors understand the nature ... περισσότερα »
A Reduction Technique for a Depressed and Impacted Nasomaxillary Buttress Fracture.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
The aim of this study is to introduce an easy method of reducing the depressed and impacted segment in a nasomaxillary buttress fracture. Through the gingiva-labial vestibular incision, the fracture segments were exposed. A blunt end of the Cottle elevator was inserted to the cleft of the fracture segments. An upward and lateral force was applied until the impacted segment was released and reduced to its anatomical position. Then, the segments were fixed with a miniplate. Fifteen patients (12 males, 3 females, mean age: 34.5 +/- 11.7 years) were operated on. In 14 patients, the fr... περισσότερα »
Primary Intraosseous Hemangioma of the Orbital Roof: A Pitfall of Surgery.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
A primary intraosseous hemangioma (IOH) of the orbital bone is extremely rare. The preferred method of treatment for IOH is total surgical excision with reconstruction. Herein, the authors describe a patient with an orbital roof IOH and the unexpected complications of ptosis and deteriorated exophthalmos. These findings showed that the total surgical excision and subsequent reconstruction provided adequate decompression and prevented further ocular complications from the orbital wall defect. (C) 2016 by Mutaz B. Habal, MD. from #ENT via xlomafota13 on Inoreader http://ift.tt/29ZsNAr... περισσότερα »
Clinical Evaluation of an Unsintered Hydroxyapatite/Poly-L-Lactide Osteoconductive Composite Device for the Internal Fixation of Maxillofacial Fractures.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Introduction: OSTEOTRANS MX (Takiron Co, Ltd, Osaka, Japan) is a resorbable osteosynthetic material composed of an unsintered hydroxyapatite/poly-l-lactide composite, and its osteoconductive capacity has been documented. The authors here report their clinical experience using OSTEOTRANS MX. Methods: The authors treated 35 patients (19 men, 16 women; age, 14-88 years; mean +/- standard deviation, 38.4 +/- 19.9 years) with maxillofacial fractures. The authors used standard surgery to stabilize fractures in all patients, fitting resorbable plates (thickness, 1.0 or 1.4 mm) and screws (... περισσότερα »
Multidisciplinary Team Treatment of Penetrating Head and Neck Trauma.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Penetrating head and neck trauma could cause significant mortality because of many important structures located in the brain and neck. Although high-velocity penetrating brain injury is often reported, reports of low-velocity, combined head and neck penetrating injury are rare. Hereby, the authors present a case of an old man who had encountered a serious accident, a 29-cm iron fork penetrated into his neck, through the skull base and into brain. After treatment by multidisciplinary team, the patient was in rehabilitation. The multidisciplinary team assists rapid diagnosis and treat... περισσότερα »
Midfacial Protraction With Skeletal Anchorage After Pterygomaxillary Separation.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
The present article reports the treatment of a 7-year-old girl with maxillary hypoplasia associated with multiple tooth agenesis through maxillary protraction with skeletal anchorage and pterygomaxillary separation. Two titanium mini-plates were placed in the lateral region of the nasal cavity and used as anchorage for maxillary protraction with a reverse-pull facemask. Pterygomaxillary separation was also performed to enhance the effects of maxillary protraction. One week after surgery, 300 g of force was applied on each side to protract the maxilla. Active treatment time was 4 mon... περισσότερα »
Efficacy of Topical Timolol as Primary Monotherapy in Cutaneous Facial Infantile Hemangiomas.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Recent studies have shown that infantile hemangiomas (IHs) undergo a rapid growth phase between 5.5 and 7.5 weeks of life and do not usually proliferate beyond 6 months; growth thereafter is usually proportionate to the child's growth. This review assesses the evidence for topical timolol as primary monotherapy for cutaneous facial IHs before 12 months of age, and to determine the differences in outcome between early (before 6 months) and late initiation (after 6 months) of timolol. A review of English language articles published up to November 2015 was performed using selected key ... περισσότερα »
Sarcoidosis Nodules on the Lateral Nasal Osteotomy Lines.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Sarcoidosis is a multisystem inflammatory disease that manifests as noncaseating granulomas, commonly in the lungs and intrathoracic lymph nodes. Subcutaneous manifestations of sarcoidosis that are caused by granulomas are referred to as specific for sarcoidosis, whereas other lesions are considered nonspecific. The authors present "sarcoidosis nodule formation on the lateral nasal osteotomy lines" in a sarcoidosis patient undergoing rhinoplasty surgery as a rare patient. Level of Evidence: V (C) 2016 by Mutaz B. Habal, MD. from #ENT via xlomafota13 on Inoreader http://ift.tt/29Zsw0... περισσότερα »
The Importance of Soft Triangle in Rhinoplasty.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
The soft triangle is a basic, yet delicate and vulnerable, subunit of the nose that is under-rated both academically and surgically. The soft triangle is located at the apex of the nostril, at the point where the dermis is in direct contact with dermis that contains no intervening subcutaneous tissue and it may be unintentionally harmed during rhinoplasty. The authors suggest using a modified incision and closure and filling with significantly or severely crushed cartilage to prevent notching and to provide support for the soft triangle. The more the authors understand the nature of... περισσότερα »
Suppurative Cervical Tuberculous Lymphadenitis Mimicking a Metastatic Neck Mass.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Tuberculosis is an important public's health problem in developing countries. Although tuberculosis is commonly found in lungs, it could also be found in lymph nodes, mouth, tonsils, tounge, nose, epiglottis, larynx, and pharynx of head-neck region. The most common form of extrapulmonary tuberculosis placed outside the lungs is tuberculous lymphadenitis. Tuberculosis lymphadenitis is the most commonly seen form of the extrapulmoner tuberculosis and usually invades the lymph nodules of the cervical region. An adult patient with tuberculous lymphadenitis has been presented within the ... περισσότερα »
A Reduction Technique for a Depressed and Impacted Nasomaxillary Buttress Fracture.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
The aim of this study is to introduce an easy method of reducing the depressed and impacted segment in a nasomaxillary buttress fracture. Through the gingiva-labial vestibular incision, the fracture segments were exposed. A blunt end of the Cottle elevator was inserted to the cleft of the fracture segments. An upward and lateral force was applied until the impacted segment was released and reduced to its anatomical position. Then, the segments were fixed with a miniplate. Fifteen patients (12 males, 3 females, mean age: 34.5 +/- 11.7 years) were operated on. In 14 patients, the frag... περισσότερα »
Midfacial Protraction With Skeletal Anchorage After Pterygomaxillary Separation.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
The present article reports the treatment of a 7-year-old girl with maxillary hypoplasia associated with multiple tooth agenesis through maxillary protraction with skeletal anchorage and pterygomaxillary separation. Two titanium mini-plates were placed in the lateral region of the nasal cavity and used as anchorage for maxillary protraction with a reverse-pull facemask. Pterygomaxillary separation was also performed to enhance the effects of maxillary protraction. One week after surgery, 300 g of force was applied on each side to protract the maxilla. Active treatment time was 4 mon... περισσότερα »
Efficacy of Topical Timolol as Primary Monotherapy in Cutaneous Facial Infantile Hemangiomas.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Recent studies have shown that infantile hemangiomas (IHs) undergo a rapid growth phase between 5.5 and 7.5 weeks of life and do not usually proliferate beyond 6 months; growth thereafter is usually proportionate to the child's growth. This review assesses the evidence for topical timolol as primary monotherapy for cutaneous facial IHs before 12 months of age, and to determine the differences in outcome between early (before 6 months) and late initiation (after 6 months) of timolol. A review of English language articles published up to November 2015 was performed using selected key ... περισσότερα »
Sarcoidosis Nodules on the Lateral Nasal Osteotomy Lines.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Sarcoidosis is a multisystem inflammatory disease that manifests as noncaseating granulomas, commonly in the lungs and intrathoracic lymph nodes. Subcutaneous manifestations of sarcoidosis that are caused by granulomas are referred to as specific for sarcoidosis, whereas other lesions are considered nonspecific. The authors present "sarcoidosis nodule formation on the lateral nasal osteotomy lines" in a sarcoidosis patient undergoing rhinoplasty surgery as a rare patient. Level of Evidence: V (C) 2016 by Mutaz B. Habal, MD. http://ift.tt/29Zsw0J
The Importance of Soft Triangle in Rhinoplasty.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
The soft triangle is a basic, yet delicate and vulnerable, subunit of the nose that is under-rated both academically and surgically. The soft triangle is located at the apex of the nostril, at the point where the dermis is in direct contact with dermis that contains no intervening subcutaneous tissue and it may be unintentionally harmed during rhinoplasty. The authors suggest using a modified incision and closure and filling with significantly or severely crushed cartilage to prevent notching and to provide support for the soft triangle. The more the authors understand the nature of... περισσότερα »
Suppurative Cervical Tuberculous Lymphadenitis Mimicking a Metastatic Neck Mass.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Tuberculosis is an important public's health problem in developing countries. Although tuberculosis is commonly found in lungs, it could also be found in lymph nodes, mouth, tonsils, tounge, nose, epiglottis, larynx, and pharynx of head-neck region. The most common form of extrapulmonary tuberculosis placed outside the lungs is tuberculous lymphadenitis. Tuberculosis lymphadenitis is the most commonly seen form of the extrapulmoner tuberculosis and usually invades the lymph nodules of the cervical region. An adult patient with tuberculous lymphadenitis has been presented within the ... περισσότερα »
A Reduction Technique for a Depressed and Impacted Nasomaxillary Buttress Fracture.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
The aim of this study is to introduce an easy method of reducing the depressed and impacted segment in a nasomaxillary buttress fracture. Through the gingiva-labial vestibular incision, the fracture segments were exposed. A blunt end of the Cottle elevator was inserted to the cleft of the fracture segments. An upward and lateral force was applied until the impacted segment was released and reduced to its anatomical position. Then, the segments were fixed with a miniplate. Fifteen patients (12 males, 3 females, mean age: 34.5 +/- 11.7 years) were operated on. In 14 patients, the frag... περισσότερα »
Clinical response to liposomal doxorubicin and rituximab in HHV-8-associated multicentric Castleman’s disease in an HIV-positive patient
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 1 July 2016 Source:Journal of Infection and Chemotherapy Author(s): Morichika Osa, Takuya Maeda, Kazuhisa Misawa, Kazuo Imai, Yuji Fujikura, Akihiko Kawana We report a patient with HIV-associated multicentric Castleman’s disease who had recurrent human herpesvirus-8 viremia associated with intermittent febrile exanthema and lymphadenopathy. Although the patient relapsed after single-agent treatment with […]
Clinical characteristics of pulmonary Mycobacterium scrofulaceum disease in 2001–2011: A case series and literature review
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 9 July 2016 Source:Journal of Infection and Chemotherapy Author(s): Shoji Suzuki, Eriko Morino, Makoto Ishii, Ho Namkoong, Kazuma Yagi, Takanori Asakura, Takahiro Asami, Hiroshi Fujiwara, Yoshifumi Uwamino, Tomoyasu Nishimura, Sadatomo Tasaka, Tomoko Betsuyaku, Jin Takasaki, Satoshi Iwata, Naoki Hasegawa BackgroundMycobacterium scrofulaceum is a well-known pathogen associated with cervical lymphadenitis in children. […]
Pityriasis Versicolor: Clinical Spectrum and Diagnosis
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Pityriasis versicolor (PV) is caused by the fungus Malassezia, especially by Malassezia globosa. The predisposing factors for PV are heat, humidity, hyperhidrosis, oral contraceptives, stress, application of oily preparations, and treatment with corticosteroids. PV is found mainly on the seborrheic areas of the trunk, shoulders, upper aspects of the arms, and neck, but it […]
Diagnosis of Midwestern Endemic Mycoses
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Histoplasmosis and blastomycosis are the two most common midwestern endemic mycoses. A history of exposure to the geographic areas in which these organisms occur is central to raising suspicion for an endemic fungal infection. For infection with these organisms, the diagnosis is definitively established by recovery of the organism in tissue or body fluids, […]
Psychosocial Factors and Sport Injuries: Meta-analyses for Prediction and Prevention
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Several studies have suggested that psychosocial variables can increase the risk of becoming injured during sport participation. Objectives The main objectives of these meta-analyses were to examine (i) the effect sizes of relationships between the psychosocial variables (suggested as injury predictors in the model of stress and athletic injury) and injury rates, and […]
Primary and Disseminated Cutaneous Coccidioidomycosis: Clinical Aspects and Diagnosis
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Coccidioidomycosis is an endemic systemic mycosis of the western hemisphere that has acquired mayor relevance after a raise in cases in the recent years. Two species, Coccidioides immitis and C. posadasii are recognized as the causative agents of this disease that, in principle, primarily affects the lungs. Extra pulmonary cutaneous forms have been more […]
Accelerometers for the Assessment of Concussion in Male Athletes: A Systematic Review and Meta-Analysis
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Concussion is common in the sporting arena and is often challenging to diagnose. The development of wearable head impact measurement systems has enabled measurement of head kinematics in contact sports. Objectives The objective of this systematic review was to determine the characteristics of head kinematics measured by an accelerometer system among male athletes […]
Zika Virus: Where Is the Treatment?
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
from Infectious Diseases via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29Lv6nK via IFTTT
The Role of Clinical Virology Laboratory and the Clinical Virology Laboratorian in Ensuring Effective Surveillance for Influenza and Other Respiratory Viruses: Points to Consider and Pitfalls to Avoid
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Opinion statement Influenza and respiratory viruses have a global impact on public health. Clinical virology laboratories and laboratorians play an important role in not only the diagnosis but also the surveillance of these pathogens. Surveillance for influenza and other respiratory pathogens is important, as it informs public health decision making in terms of influenza vaccine […]
Submaximal Step Tests to Estimate Maximal Oxygen Uptake in Healthy Adults: Methodological Issues About Validity and Reliability
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29CoIni via IFTTT
Corrigendum to “depletion of the “gamma-type carbonic anhydrase-like” subunits of complex I affects central mitochondrial metabolism in Arabidopsis thaliana” Biochim. Biophys. Acta 1857 (2016) 60–71
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Issue 9 Author(s): Steffanie Fromm, Jennifer Göing, Christin Lorenz, Christoph Peterhänsel, Hans-Peter Braun from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ZuM7Y via IFTTT
Six-Month Urinary CCL2 and CXCL10 Levels Predict Long-Term Renal Allograft Outcome.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Early prognostic markers that identify high-risk patients could lead to increased surveillance, personalized immunosuppression, and improved long-term outcomes. The goal of this study was to validate 6-month urinary chemokine ligand 2 (CCL2) as a noninvasive predictor of long-term outcomes and compare it with 6-month urinary CXCL10. Methods: A prospective, observational renal transplant cohort (n… Continue reading Six-Month Urinary CCL2 and CXCL10 Levels Predict Long-Term Renal Allograft Outcome.
Corticosteroid Use and Growth After Pediatric Solid Organ Transplantation: A Systematic Review and Meta-Analysis.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: A number of corticosteroid minimization and avoidance protocols for post-solid organ transplant have been developed. The study objective was to examine the effect of corticosteroid withdrawal/avoidance on growth and safety parameters in pediatric solid organ transplant recipients. Methods: A systematic review using Medline and Embase was performed. All randomized controlled trials (RCT) and observational… Continue reading Corticosteroid Use and Growth After Pediatric Solid Organ Transplantation: A Systematic Review and Meta-Analysis.
Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Blood group incompatible transplantation (ABOi) in children is rare as pretransplant conditioning remains challenging and concerns persist about the potential increased risk of rejection. Methods: We describe the results of 11 ABOi pediatric renal transplant recipients in the 2 largest centers in the United Kingdom, sharing the same tailored desensitization protocol. Patients with pretransplant… Continue reading Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation.
Twelve-Week Rifapentine Plus Isoniazid Versus 9-Month Isoniazid for the Treatment of Latent Tuberculosis in Renal Transplant Candidates.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Renal transplant candidates (RTC) with latent tuberculosis infection (LTBI) are at significant risk for tuberculosis reactivation. Twelve-week rifapentine (RPT)/isoniazid (INH) is effective for LTBI but clinical experience in RTC is scarce. Methods: We conducted a retrospective study of RTC with LTBI treated with either 12-week RPT/INH or 9-month INH from March 1, 2012, through… Continue reading Twelve-Week Rifapentine Plus Isoniazid Versus 9-Month Isoniazid for the Treatment of Latent Tuberculosis in Renal Transplant Candidates.
Comparative Study of the Immunoregulatory Capacity of In Vitro Generated Tolerogenic Dendritic Cells, Suppressor Macrophages, and Myeloid-Derived Suppressor Cells.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Regulatory myeloid cell (RMC) therapy is a promising strategy for the treatment of immunological disorders such as autoimmune disease and allograft transplant rejection. Various RMC subsets can be derived from total bone marrow using different protocols, but their phenotypes often overlap, raising questions about whether they are truly distinct. Methods: In this study, we… Continue reading Comparative Study of the Immunoregulatory Capacity of In Vitro Generated Tolerogenic Dendritic Cells, Suppressor Macrophages, and Myeloid-Derived Suppressor Cells.
HLA Mismatch and Allograft Survival.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
No abstract available http://ift.tt/29GIABZ from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29FnmVG via IFTTT
Selected Mildly Obese Donors Can Be Used Safely in Simultaneous Pancreas and Kidney Transplantation.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Donor obesity, defined as donor body mass index (D-BMI) of 30 kg/m2 or greater, has been associated with increased risk of technical failure and poor pancreas allograft outcomes. Many transplant centers establish a threshold of D-BMI of 30 kg/m2 to decline donor offers for pancreas transplantation. However, no previous studies differentiate the impact of… Continue reading Selected Mildly Obese Donors Can Be Used Safely in Simultaneous Pancreas and Kidney Transplantation.
Effect of a Mobile Web App on Kidney Transplant Candidates’ Knowledge About Increased Risk Donor Kidneys: A Randomized Controlled Trial.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Kidney transplant candidates (KTCs) must provide informed consent to accept kidneys from increased risk donors (IRD), but poorly understand them. We conducted a multisite, randomized controlled trial to evaluate the efficacy of a mobile Web application, Inform Me, for increasing knowledge about IRDs. Methods: Kidney transplant candidates undergoing transplant evaluation at 2 transplant centers… Continue reading Effect of a Mobile Web App on Kidney Transplant Candidates’ Knowledge About Increased Risk Donor Kidneys: A Randomized Controlled Trial.
Six-Month Urinary CCL2 and CXCL10 Levels Predict Long-Term Renal Allograft Outcome.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Early prognostic markers that identify high-risk patients could lead to increased surveillance, personalized immunosuppression, and improved long-term outcomes. The goal of this study was to validate 6-month urinary chemokine ligand 2 (CCL2) as a noninvasive predictor of long-term outcomes and compare it with 6-month urinary CXCL10. Methods: A prospective, observational renal transplant cohort (n… Continue reading Six-Month Urinary CCL2 and CXCL10 Levels Predict Long-Term Renal Allograft Outcome.
Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 2 ώρες
Experience with clinical liver xenotransplantation has largely involved the transplantation of livers from nonhuman primates. Experience with pig livers has been scarce. This brief review will be restricted to assessing the potential therapeutic impact of pig liver xenotransplantation in acute liver failure and the remaining barriers that currently do not justify clinical trials. A relatively new surgical technique of heterotopic pig liver xenotransplantation is described that might play a role in bridging a patient with acute liver failure until either the native liver recovers or ... περισσότερα »
Perioperative Events and Complications in Minimally Invasive Live Donor Nephrectomy: A Systematic Review and Meta-Analysis.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 2 ώρες
Background: Minimally invasive live donor nephrectomy has become a fully implemented and accepted procedure. Donors have to be well educated about all risks and details during the informed consent process. For this to be successful, more information regarding short-term outcome is necessary. Methods: A literature search was performed; all studies discussing short-term complications after minimally invasive live donor nephrectomy were included. Outcomes evaluated were intraoperative and postoperative complications, conversions, operative and warm ischemia times, blood loss, length of... περισσότερα »
UCP2 Expression Is Increased in Pancreas From Brain-Dead Donors and Involved in Cytokine-Induced [beta] Cells Apoptosis.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 2 ώρες
Background: Systemic inflammation associated with brain death (BD) decreases islet yield and quality, negatively affecting outcomes of human islet transplantation. A recent study from our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with BD as compared with controls. UCP2 is located in the mitochondrial inner membrane and regulates production of reactive oxygen species and glucose-stimulated insulin secretion. It has been suggested that UCP2 also plays a role in [beta] cell apoptosis, but these findings remain controversial. Methods: We h... περισσότερα »
Adherence to and Acceptance of Once-Daily Tacrolimus After Kidney and Liver Transplant: Results From OSIRIS, a French Observational Study.
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 2 ώρες
Background: Adherence to immunosuppressive treatments is a major concern in transplanted patients. Methods: This 6-month French observational, longitudinal, prospective study aimed to assess patient adherence to and acceptance of once-daily tacrolimus (Advagraf) initiation in kidney and liver transplant recipients. Data from 1106 patients initiating once-daily tacrolimus during posttransplant follow-up were analyzed. Adherence and acceptance were assessed using self-administered questionnaires at inclusion and at 3 and 6 months. Results: Mean age was 52.4 +/- 13.2 years, 61.5% were ... περισσότερα »
Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες
Experience with clinical liver xenotransplantation has largely involved the transplantation of livers from nonhuman primates. Experience with pig livers has been scarce. This brief review will be restricted to assessing the potential therapeutic impact of pig liver xenotransplantation in acute liver failure and the remaining barriers that currently do not justify clinical trials. A relatively new surgical technique of heterotopic pig liver xenotransplantation is described that might play a role in bridging a patient with acute liver failure until either the native liver recovers or ... περισσότερα »
Place dependent stimulation rates improve pitch perception in cochlear implantees with single-sided deafness
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: September 2016 *Source:*Hearing Research, Volume 339 Author(s): Tobias Rader, Julia Döge, Youssef Adel, Tobias Weissgerber, Uwe Baumann In normal hearing, the pitch of an acoustic tone can theoretically be encoded by either the place of stimulation in the cochlea or the corresponding rate of vibration. Thus spectral attributes and temporal fine structure of an acoustic signal are naturally correlated. Cochlear implants (CIs), neural prosthetic devices that restore hearing in the profoundly hearing impaired, currently disregard this mechanism; electrical stimulation ... περισσότερα »
Subcortical correlates of auditory perceptual organization in humans
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: September 2016 *Source:*Hearing Research, Volume 339 Author(s): Shimpei Yamagishi, Sho Otsuka, Shigeto Furukawa, Makio Kashino To make sense of complex auditory scenes, the auditory system sequentially organizes auditory components into perceptual objects or streams. In the conventional view of this process, the cortex plays a major role in perceptual organization, and subcortical mechanisms merely provide the cortex with acoustical features. Here, we show that the neural activities of the brainstem are linked to perceptual organization, which alternates spontaneousl... περισσότερα »
Endolymph movement visualized with light sheet fluorescence microscopy in an acute hydrops model
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: September 2016 *Source:*Hearing Research, Volume 339 Author(s): Daniel J. Brown, Christopher J. Pastras, Ian S. Curthoys, Cassandra S. Southwell, Lieke Van Roon There are a variety of techniques available to investigate endolymph dynamics, primarily seeking to understand the cause of endolymphatic hydrops. Here we have taken the novel approach of injecting, via a glass micropipette, fluorescein isothiocyanate–dextran (FITC-dex) and artificial endolymph into scala media of anaesthetized guinea pigs, with subsequent imaging of the inner ear using Light Sheet Fluorescen... περισσότερα »
Correlation between word recognition score and intracochlear new bone and fibrous tissue after cochlear implantation in the human
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 29 June 2016 *Source:*Hearing Research Author(s): Takefumi Kamakura, Joseph B. Nadol Cochlear implantation is an effective, established procedure for patients with profound deafness. Although implant electrodes have been considered as biocompatible prostheses, surgical insertion of the electrode induces various changes within the cochlea. Immediate changes include insertional trauma to the cochlea. Delayed changes include a tissue response consisting of inflammation, fibrosis and neo-osteogenesis induced by trauma and an immunologic reaction to a for... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech understanding in noise is... περισσότερα »
Crossmodal plasticity in auditory, visual and multisensory cortical areas following noise-induced hearing loss in adulthood
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 4 July 2016 *Source:*Hearing Research Author(s): Ashley L. Schormans, Marei Typlt, Brian L. Allman Complete or partial hearing loss results in an increased responsiveness of neurons in the core auditory cortex of numerous species to visual and/or tactile stimuli (i.e., crossmodal plasticity). At present, however, it remains uncertain how adult-onset partial hearing loss affects higher-order cortical areas that normally integrate audiovisual information. To that end, extracellular electrophysiological recordings were performed under anesthesia in nois... περισσότερα »
Place dependent stimulation rates improve pitch perception in cochlear implantees with single-sided deafness
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: September 2016 *Source:*Hearing Research, Volume 339 Author(s): Tobias Rader, Julia Döge, Youssef Adel, Tobias Weissgerber, Uwe Baumann In normal hearing, the pitch of an acoustic tone can theoretically be encoded by either the place of stimulation in the cochlea or the corresponding rate of vibration. Thus spectral attributes and temporal fine structure of an acoustic signal are naturally correlated. Cochlear implants (CIs), neural prosthetic devices that restore hearing in the profoundly hearing impaired, currently disregard this mechanism; electrical stimulation ... περισσότερα »
Subcortical correlates of auditory perceptual organization in humans
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: September 2016 *Source:*Hearing Research, Volume 339 Author(s): Shimpei Yamagishi, Sho Otsuka, Shigeto Furukawa, Makio Kashino To make sense of complex auditory scenes, the auditory system sequentially organizes auditory components into perceptual objects or streams. In the conventional view of this process, the cortex plays a major role in perceptual organization, and subcortical mechanisms merely provide the cortex with acoustical features. Here, we show that the neural activities of the brainstem are linked to perceptual organization, which alternates spontaneousl... περισσότερα »
Endolymph movement visualized with light sheet fluorescence microscopy in an acute hydrops model
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: September 2016 *Source:*Hearing Research, Volume 339 Author(s): Daniel J. Brown, Christopher J. Pastras, Ian S. Curthoys, Cassandra S. Southwell, Lieke Van Roon There are a variety of techniques available to investigate endolymph dynamics, primarily seeking to understand the cause of endolymphatic hydrops. Here we have taken the novel approach of injecting, via a glass micropipette, fluorescein isothiocyanate–dextran (FITC-dex) and artificial endolymph into scala media of anaesthetized guinea pigs, with subsequent imaging of the inner ear using Light Sheet Fluorescen... περισσότερα »
Correlation between word recognition score and intracochlear new bone and fibrous tissue after cochlear implantation in the human
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 29 June 2016 *Source:*Hearing Research Author(s): Takefumi Kamakura, Joseph B. Nadol Cochlear implantation is an effective, established procedure for patients with profound deafness. Although implant electrodes have been considered as biocompatible prostheses, surgical insertion of the electrode induces various changes within the cochlea. Immediate changes include insertional trauma to the cochlea. Delayed changes include a tissue response consisting of inflammation, fibrosis and neo-osteogenesis induced by trauma and an immunologic reaction to a for... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech understanding in noise is... περισσότερα »
Crossmodal plasticity in auditory, visual and multisensory cortical areas following noise-induced hearing loss in adulthood
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 4 July 2016 *Source:*Hearing Research Author(s): Ashley L. Schormans, Marei Typlt, Brian L. Allman Complete or partial hearing loss results in an increased responsiveness of neurons in the core auditory cortex of numerous species to visual and/or tactile stimuli (i.e., crossmodal plasticity). At present, however, it remains uncertain how adult-onset partial hearing loss affects higher-order cortical areas that normally integrate audiovisual information. To that end, extracellular electrophysiological recordings were performed under anesthesia in nois... περισσότερα »
Repeated OnabotulinumtoxinA Treatment of Glabellar Lines at Rest Over 3 Treatment Cycles.
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
BACKGROUND: OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at rest; however, less is known regarding the effect of repeat treatment on more severe lines at rest. OBJECTIVE: To assess the effect of repeated onabotulinumtoxinA treatment for reduction of glabellar lines at rest. METHODS: Subjects 18 to 75 years old with at least mild glabellar lines at rest, as assessed by the validated Facial Wrinkle Scale (FWS) with photonumeric guide (score >= 1), received 3 treatments of 20 U onabotulinumtoxinA 4 months apart (N = 225). "Response" was defined as e... περισσότερα »
How I Do It: Treatment of Plantar Calluses and Corns With an Erbium-Doped Yttrium Aluminum Garnet Laser.
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
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