High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody: Cancer can occur in patients with inflammatory myopathies. This association is mainly observed in dermatomyositis, and myositis-specific antibodies have allowed us to delineate patients at an increased risk. Malignancy is also reported in patients with necrotizing autoimmune myopathies, but the risk remains […]
Zika virus-associated neurological disorders
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
a review: Zika virus, an arbovirus transmitted by mosquitoes of the Aedes species, is now rapidly disseminating throughout the Americas and the ongoing Brazilian outbreak is the largest Zika virus epidemic so far described. In addition to being associated with a non-specific acute febrile illness, a number of neurological manifestations, mainly microcephaly and Guillain-Barré syndrome, […]
Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate: Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction. Post-translational modifications including phosphorylation, ubiquitination and truncation, are characteristic features of tau present in the brain in […]
Orthostatic tremor: a cerebellar pathology?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Orthostatic tremor: a cerebellar pathology?: See Muthuraman et al. (doi:10.1093/aww164) for a scientific commentary on this article. Primary orthostatic tremor is characterized by high frequency tremor affecting the legs and trunk during the standing position. Cerebellar defects were suggested in orthostatic tremor without direct evidence. We aimed to characterize the anatomo-functional defects of the cerebellar […]
Functional brain imaging of episodic memory decline in ageing
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Functional brain imaging of episodic memory decline in ageing: Abstract The episodic long-term memory system supports remembering of events. It is considered to be the most age-sensitive system, with an average onset of decline around 60 years of age. However, there is marked interindividual variability, such that some individuals show faster than average change and […]
Isolation-induced vocalization depends on the nucleus accumbens
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Isolation-induced vocalization in the infant rat depends on the nucleus accumbens: Abstract Mammalian infants vocalize when socially isolated. Vocalization guides the return of the caregiver and thereby maintains an environment critical to the infant’s survival. Although the role of the periaqueductal gray area (PAG) in these vocalizations is established, other aspects of the relevant neural […]
Asymptomatic, velvety, thickened orange-brown plaques distributed in an arciform pattern along the scapular region.Unilateral nevoid acanthosis nigricans treated with CO2 laser
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Unilateral nevoid acanthosis nigricans treated with CO2 laser: Description Acanthosis nigricans (AN) can be classified into eight variants, including the benign, obesity associated, syndromic, malignant, acral, unilateral, medication induced and mixed type.1 Unilateral nevoid AN (UNAN) is an extremely rare form of AN and may be localised as a solitary lesion or along the Blaschko’s […]
Epidermal Growth Factor and Intestinal Barrier Function
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Epidermal Growth Factor and Intestinal Barrier Function: Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption […]
8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma: Asthma is characterized by reversible airway narrowing, shortness of breath, wheezing, coughing, and other symptoms driven by chronic inflammatory processes, commonly triggered by allergens. In 90% of asthmatics, most of these symptoms can also be triggered by intense physical activities and […]
Combination of Methylprednisolone and Tranilast after Spinal Cord Injury
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Evaluation of the Combination of Methylprednisolone and Tranilast after Spinal Cord Injury in Rat Models J Korean Neurosurg Soc. 2016 Jul;59(4):334-40 Authors: Mbori NJ, Chuan XY, Feng QX, Alizada M, Zhan J Abstract OBJECTIVE: The aim of our study was to evaluate the neuroprotective functions of the combination therapy using methylprednisolone (MP) and tranilast (TR) […]
P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma
[image: cover.gif?v=1&s=519d25c171273df3916a3269] Abstract Alveolar rhabdomyosarcoma (ARMS) is an aggressive paediatric cancer of skeletal muscle with poor prognosis. A PAX3-FOXO1 fusion protein acts as a driver of malignancy in ARMS by disrupting tightly coupled but mutually exclusive pathways of proliferation and differentiation. While PAX3-FOXO1 is an attractive therapeutic target, no current treatments are designed to block its oncogenic activity. The present work shows that the histone acetyltransferase P/CAF (KAT2B) is overexpressed in primary tumours from ARMS patients. In... περισσότερα »
Mitophagy: Mechanisms and Role in Human Disease
Abstract Mitophagy is a selective form of macro-autophagy in which mitochondria are specifically targeted for autophagic degradation. Mitophagy plays an important role in cellular homeostasis by eliminating dysfunctional mitochondria and reducing mitochondrial mass as an adaptive response to stress. Cells execute mitophagy through several non-redundant mechanisms, including the PINK1/Parkin partnership that modulates turnover of depolarized mitochondria and stress-induced BNIP3, NIX and FUNDC1 molecular adaptors that interact directly with LC3 to promote mitophagy. These pathways ... περισσότερα »
Journal of Postgraduate Medicine Education and Research
Alexandros G. SfakianakisστοMedical Articles from India and Jaypee Journals by Sfakianakis G. AlexandrosΠριν από 6 δευτερόλεπτα
Table of Contents 2016| July-September | Issue 3 1. Editorial Platelet-rich Plasma in Osteoarthritis Knee: Status Report Sandeep Patel, Mandeep S Dhillon iv-vi Full Text PDF | Abstract |FREE 2. Original Research Comparison of Two Methods: Problem-based Learning vs Lecture in Integrated Management of Childhood Illness Workshops Fardin Assadi, Parisa Khoshnevisasl, Mansor Sadeghzadeh, Korosh Kamali 123-126 Full Text PDF | Abstract | 10.5005/jp-journals-10028-1203 |FREE 3. Original Research Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in ... περισσότερα »
Genes, Vol. 7, Pages 40: Replication Termination: Containing Fork Fusion-Mediated Pathologies in Escherichia coli
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Duplication of bacterial chromosomes is initiated via the assembly of two replication forks at a single defined origin. Forks proceed bi-directionally until they fuse in a specialised termination area opposite the origin. This area is flanked by polar replication fork pause sites that allow forks to enter but not to leave. The precise function of […]
Delirium in advanced cancer patients often goes undetected in the emergency departmenthttps://t.co/EgD6I4j8Nu https://t.co/M4goA3ZhLQ
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Delirium in advanced cancer patients often goes undetected in the emergency department https://t.co/EgD6I4j8Nu https://t.co/M4goA3ZhLQ from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/757503346861309953 via IFTTT
Register today for accredited e-learning and earn 1 CME point! https://t.co/b2BmhOlXp9 https://t.co/w4dwzgAiXV
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Register today for accredited e-learning and earn 1 CME point! https://t.co/b2BmhOlXp9 https://t.co/w4dwzgAiXV from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/757501389283229697 via IFTTT
Validation and in-vivo assessment of an innovative satellite-based solar UV dosimeter for a mobile app dedicated to skin health
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Photochem. Photobiol. Sci., 2016, Accepted Manuscript DOI: 10.1039/C6PP00129G, Paper Marco Morelli, Andrea Masini, Emilio Simeone, Marina Khazova We present an innovative satellite-based solar UV (ultraviolet) radiation dosimeter with a mobile app interface that has been validated by exploiting both ground-based measurements and an in-vivo assessment of the… The content of this RSS Feed (c) The […]
Editor’s Choice for July 2016
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Prof Gordon McVie provides highlights from ecancer for July 2016: Events ecancer’s Future Horizons in Lung Cancer event Highlights from the first International ecancer Conference on Oncology and Radiotherapy, 6–7 May 2016, Santiago,… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ad7H3D via IFTTT
Editorial Board Page
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/2abgAK8
Table of Contents
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/29YRMSg
AAOMS Author Disclosure forms
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/2abfLRD
Help Us Remember Our History
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): James R. Hupp http://ift.tt/29YRv1D
Masthead
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/2abg2Uj
Clinical Focus - Crestal Approach for Sinus Floor Augmentation
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Michael S. Block http://ift.tt/29YRWZC
More than Bisphosphonates
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): M. Anthony Pogrel http://ift.tt/2abgbqV
News and Announcements
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/29YRUB7
A Novel Method of Orbital Floor Reconstruction Using Virtual Planning, 3-Dimensional Printing, and Autologous Bone
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Maarten Vehmeijer, Maureen van Eijnatten, Niels Liberton, Jan Wolff Fractures of the orbital floor are often a result of traffic accidents or interpersonal violence. To date, numerous materials and methods have been used to reconstruct the orbital floor. However, simple and cost-effective 3-dimensional (3D) printing technologies for the treatment of orbital floor fractures are still sought. This study describes a simple, precise, cost-effective method of treating orbital fra... περισσότερα »
Efficacy of Retromandibular Transparotid Approach for the Management of Extracapsular Subcondylar Mandibular Fractures Using 2-mm Titanium Miniplates: A Prospective Clinical Study
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Narotam Kumar Ghezta, Yogesh Bhardwaj, Pooja Rani, Rangila Ram PurposeThe aim of this study was to evaluate the long-term clinical and radiologic results of the retromandibular transparotid approach to displaced extracapsular subcondylar mandibular fractures.Patients and MethodsA prospective cohort study was conducted over a period of 5 years on patients surgically treated for displaced extracapsular subcondylar mandibular fractures by the retromandibular transparotid approac... περισσότερα »
Editorial Board Page
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/2abgAK8 via IFTTT
Table of Contents
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29YRMSg via IFTTT
AAOMS Author Disclosure forms
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/2abfLRD via IFTTT
Help Us Remember Our History
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): James R. Hupp from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29YRv1D via IFTTT
Masthead
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/2abg2Uj via IFTTT
Value of a coordinated management of osteoporosis via Fracture Liaison Service for the treatment of orthogeriatric patients
AbstractIntroduction The prevalence of osteoporosis in female patients over 75 years of age is 59.2 %. In Germany ~6.3–7.8 million patients are affected by osteoporosis. In 77 % of german patients osteoporosis is not treated adequately. Even after fragility fractures only 16–21 % of female patients and 3 % of male patients are supplied with a specific osteoporosis therapy. Establishing a Fracture Liaison Services (FLS) is a possible addition to co-management for an efficient treatment of osteoporosis in orthogeriatric patients. Materials and methods According to a treatment algorith... περισσότερα »
The protective effect of Shenfu injection against elderly severe pneumonia
AbstractObjective The purpose of this study is to investigate the effect of Shenfu injection (SFI) on the tumor necrosis factor-α (TNF-α) and the interleukin (IL-6, IL-8, IL-10) of elderly patients who suffered from severe pneumonia. Methods From June 2012 to September 2014, we performed in our department 89 cases of elderly patients with severe pneumonia. These patients were randomly divided into two groups: the treatment group (45 cases) and the control group (44 cases). The control group was given the treatment of anti-infection, reducing sputum, and support therapy, while the tr... περισσότερα »
OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages
While OPN is an important mediator of muscle remodeling in health and disease, functional differences in human spliced OPN variants in the muscle microenvironment have not been characterized. We thus sought to define the pro-inflammatory activities of human OPN isoforms (OPN-a, OPN-b, and OPN-c) on cells present in regenerating muscle. OPN transcripts were quantified in normal and dystrophic human and dog muscle. Human macrophages and myoblasts were stimulated with recombinant human OPN protein isoforms and cytokine mRNA and protein induction was assayed. OPN isoforms were greatly ... περισσότερα »
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma: AbstractThe spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The ubiquitin-specific protease 39 (USP39) is essential for pre-mRNA splicing, and upregulated USP39 expression is noted in a variety of cancers. However, the role of USP39 in the development and progression of melanoma remai... περισσότερα »
Effects of radiation on the temporal bone in patients with head and neck cancer
Effects of radiation on the temporal bone in patients with head and neck cancer: Abstract Radiotherapy is a key component in the treatment of many head and neck cancers, and its potential to cause long-term adverse effects has become increasingly recognized. In this review, we describe the short-term and long-term sequelae of radiation-associated changes in and injury to the temporal bone and its related structures. The pathophysiology of radiation-induced injury and its clinical entities, including sensorineural hearing loss, chronic otitis media, osteoradionecrosis, and radiatio... περισσότερα »
Factors influencing oncologic outcome in patients with early-intermediate glottic cancer treated by transoral laser microsurgery
Retrospective analysis of [image: cover.gif?v=1&s=f302950f6434daecbd65a56c] Abstract Background The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM). Methods This was a retrospective mono-institutional study. A total of 590 patients with cTis-cT3 glottic cancer underwent TLM with curative intent. Results TLM alone was performed in 538 patients (91.2%) and TLM followed by adjuvant radiotherapy (RT) was done in 52 (8.8%). Five-year recurrence-free surviv... περισσότερα »
Orbital Floor Reconstruction Using Virtual Planning, 3-Dimensional Printing, and Autologous Bone
A Novel Method of via Oral and Maxillofacial Surgery Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Maarten Vehmeijer, Maureen van Eijnatten, Niels Liberton, Jan Wolff Fractures of the orbital floor are often a result of traffic accidents or interpersonal violence. To date, numerous materials and methods have been used to reconstruct the orbital floor. However, simple and cost-effective 3-dimensional (3D) printing technologies for the treatment of orbital floor fractures are still sought. This study describes a simple, ... περισσότερα »
Slut Shaming (condemnation aimed at presumably sexually active females) as a form of bullying
Slut Shaming in a School Bullying Case: Evaluators Ignore Level of Harm When the Victim Self-Presents as Sexually Available: AbstractTo investigate slut shaming (condemnation aimed at presumably sexually active females) as a form of bullying, we asked 142 U.S. college students acting as disciplinary committee members to decide a case involving two female high school students. We manipulated the victim’s self-presentation (sexually available, control) and the level of harm she suffered (mild anxiety, PTSD). Although evaluators typically make more pro-victim judgments when the level ... περισσότερα »
OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages
OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages: While OPN is an important mediator of muscle remodeling in health and disease, functional differences in human spliced OPN variants in the muscle microenvironment have not been characterized. We thus sought to define the pro-inflammatory activities of human OPN isoforms (OPN-a, OPN-b, and OPN-c) on cells present in regenerating muscle. OPN transcripts were quantified in normal and dystrophic human and dog muscle. Human macrophages and myoblasts were stimulated with recombinan... περισσότερα »
Do we end life well?
Do we end life well?: Many general pediatricians and subspecialists believe that their clinical acumen caring for a child while ill extends equally well to the end of life. But do we end life well? Do we meet the needs of families and their dying child? In this volume of The Journal, Lövgren et al report their results from a cross-sectional survey of Swedish parents whose 40 children died from spinal muscular atrophy types I or II. Although end of life from this neurodegenerative disease may not exemplify all other pediatric deaths, and some practices in this study could be specific ... περισσότερα »
Vaccine Hesitancy and Refusal
Vaccine Hesitancy and Refusal: Over the past few years, an increasing number of European pediatricians, particularly primary care pediatricians, are facing the growing threat of vaccine hesitancy and refusal, a sort of a “cultural epidemic,” which seems to progressively affect the families of children under their care. In several communities, a growing number of individuals are delaying or refusing available recommended and/or mandatory vaccinations for themselves and their children. Furthermore, vaccination is increasingly perceived as unsafe and unnecessary by a rising number of p... περισσότερα »
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) during viral illness and occurrence of pneumonia with empyema
Nonsteroidal anti-inflammatory drugs: risks outweigh benefits: Investigators from 15 medical centers in France performed a case-control study to evaluate a hypothesized association between use of nonsteroidal anti-inflammatory drugs (NSAIDs) during viral illness and occurrence of pneumonia with empyema. Cases were consecutive children 3 months through 15 years of age hospitalized at participating centers with thoracentesis-proven bacterial pneumonia. Cases also had to have a physician-diagnosed acute viral illness during the 15 days prior to hospitalization.
Life-threatening airway compromise complicating a neck dissection
*Life*-*threatening neck *hematoma *complicating *thyroid and parathyroid surgery MA Rosenbaum, M Haridas, CR McHenry - The American Journal of …, 2008 - Elsevier *...* of a postoperative *neck* hematoma include early detection, close observation, *airway* management, and *...* The patient did not develop respiratory *compromise* and did not require surgical evacuation *...* patients who are being anticoagulated, and they can be *life*-*threatening*, as was *...* Γίνεται αναφορά σε 67 Σχετικά άρθρα Όλες οι 6 εκδοχές Παράθεση Αποθήκευση Intrapartum *airway *management for giant fetal ... περισσότερα »
Chronic inflammatory demyelinating polyneuropathy (CIDP)
Terminal complement activation is increased and associated with disease severity in CIDP: Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common chronic autoimmune neuropathy. While both cell-mediated and humoral mechanisms contribute to its pathogenesis, the rapid clinical response to plasmapheresis implicates a circulating factor responsible for peripheral nerve injury. We report that treatment-naïve patients with CIDP show increased serum and CSF levels of the anaphylatoxin C5a and the soluble terminal complement complex (sTCC). Systemic terminal co... περισσότερα »
Epidermal Growth Factor and Intestinal Barrier Function
Epidermal Growth Factor and Intestinal Barrier Function: Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, ... περισσότερα »
8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma
The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma: Asthma is characterized by reversible airway narrowing, shortness of breath, wheezing, coughing, and other symptoms driven by chronic inflammatory processes, commonly triggered by allergens. In 90% of asthmatics, most of these symptoms can also be triggered by intense physical activities and severely exacerbated by environmental factors. This condition is known as exercise-induced asthma (EIA). Current theories explaining EIA pathogenesis involve osmotic and/or thermal alte... περισσότερα »
Combination of Methylprednisolone and Tranilast after Spinal Cord Injury
Evaluation of the Combination of Methylprednisolone and Tranilast after Spinal Cord Injury in Rat Models J Korean Neurosurg Soc. 2016 Jul;59(4):334-40 Authors: Mbori NJ, Chuan XY, Feng QX, Alizada M, Zhan J Abstract OBJECTIVE: The aim of our study was to evaluate the neuroprotective functions of the combination therapy using methylprednisolone (MP) and tranilast (TR) after spinal cord injury (SCI) in adult rats. METHODS: Spinal cord compression injury model was achieved using Yasargil aneurysm clip. Rats were divided into control group, MP group, TR group, and combination therapy ... περισσότερα »
Early Progressive Infarction in Middle Cerebral Artery Occlusion.
Perfusion-Weighted MRI Parameters for Prediction of J Korean Neurosurg Soc. 2016 Jul;59(4):346-51 Authors: Kim H, Kim Y, Kim YW, Kim SR, Yang SH Abstract OBJECTIVE: Early progressive infarction (EPI) is frequently observed and related to poor functional outcome in patients with middle cerebral artery (MCA) infarction caused by MCA occlusion. We evaluated the perfusion parameters of magnetic resonance imaging (MRI) as a predictor of EPI. METHODS: We retrospectively analyzed patients with acute MCA territory infarction caused by MCA occlusion. EPI was defined as a National Institute... περισσότερα »
Manual Aspiration Thrombectomy Using Penumbra Catheter in Patients with Acute M2 Occlusion : A Single-Center Analysis.
: A Single-Center Analysis.: J Korean Neurosurg Soc. 2016 Jul;59(4):352-6 Authors: Park JS, Kwak HS Abstract OBJECTIVE: The efficacy and safety of manual aspiration thrombectomy using Penumbra in an acute occlusion of large intracranial arteries has been proven in many previous studies. Our study aimed to retrospectively assess the efficacy and safety of manual aspiration thrombectomy using Penumbra in patients with small vessel occlusions (M2 segment of the MCA). METHODS: We conducted a retrospective review of 32 patients who underwent manual aspiration thrombectomy using the Pe... περισσότερα »
Anaplastic Meningiomas,Meningiomas with Rhabdoid or Papillary Components
Meningiomas with Rhabdoid or Papillary Components : Prognosis and Comparison with Anaplastic Meningiomas.: J Korean Neurosurg Soc. 2016 Jul;59(4):357-62 Authors: Kim JK, Jung TY, Jung S, Lee KH, Kim SK, Lee EJ Abstract Papillary and rhabdoid meningiomas are pathologically World Health Organization (WHO) grade III. Any correlation between clinical prognosis and pathologic component is not clear. We analyzed the prognoses of patients with meningiomas with a rhabdoid or papillary component compared to those of patients with anaplastic meningiomas. From 1994 to June 2013, 14 anaplasti... περισσότερα »
Posterior Cervical Inclinatory Foraminotomy.
Long-Term Outcome of J Korean Neurosurg Soc. 2016 Jul;59(4):374-8 Authors: Heo J, Chang JC, Park HK Abstract OBJECTIVE: A modified surgical technique of posterior cervical foramintomy called posterior cervical inclinatory foraminotomy (PCIF) was introduced in previous preliminary article. PCIF allows better preservation of facet joint and capsule than conventional techniques. The authors conducted a study to investigate long-term outcomes of PCIF. METHODS: We retrospectively reviewed demographic, radiologic, and clinical data from the patients who underwent PCIFs at our instituti... περισσότερα »
Proximal Aspiration Thrombectomy for Using Balloon-Tipped Guide Catheter in Acute Intracranial Internal Carotid Artery Occlusion.
Efficacy of J Korean Neurosurg Soc. 2016 Jul;59(4):379-84 Authors: Kim YW, Kang DH, Hwang YH, Park J, Kim YS Abstract OBJECTIVE: Mechanical thrombectomy (MT) for acute intracranial internal carotid artery (ICA) occlusion is often complicated by difficult revascularization and non-involved territory embolization possibly related with larger clot-burden. This study aims to evaluate the efficacy of proximal aspiration thrombectomy (PAT) using a balloon-tipped guide catheter for clot-burden reduction in such cases with period-to-period analysis (period 1 : standard MT without PAT; pe... περισσότερα »
Gamma Knife Radiosurgery for Metastatic Brain Tumors
Clinical Outcomes of Gamma Knife Radiosurgery for Metastatic Brain Tumors from Gynecologic Cancer : Prognostic Factors in Local Treatment Failure and Survival.: J Korean Neurosurg Soc. 2016 Jul;59(4):392-9 Authors: Shin HK, Kim JH, Lee do H, Cho YH, Kwon do H, Roh SW Abstract OBJECTIVE: Brain metastases in gynecologic cancer (ovarian, endometrial, and cervical cancer) patients are rare, and the efficacy of Gamma Knife Radiosurgery (GKRS) to treat these had not been evaluated. We assessed the efficacy of GKRS and prognostic factors for tumor control and survival in brain metastasis... περισσότερα »
Acute Ischemic Stroke Involving Both Anterior and Posterior Circulation
Treated by Endovascular Revascularization for Acute Basilar Artery Occlusion via Persistent Primitive Trigeminal Artery.: J Korean Neurosurg Soc. 2016 Jul;59(4):400-4 Authors: Imahori T, Fujita A, Hosoda K, Kohmura E Abstract We report a case of acute ischemic stroke involving both the anterior and posterior circulation associated with a persistent primitive trigeminal artery (PPTA), treated by endovascular revascularization for acute basilar artery (BA) occlusion via the PPTA. An otherwise healthy 67-year-old man experienced sudden loss of consciousness and quadriplegia. Magnetic... περισσότερα »
Supratentorial Meningiomas.
Experience with 7.0 T MRI in Patients with J Korean Neurosurg Soc. 2016 Jul;59(4):405-9 Authors: Song SW, Son YD, Cho ZH, Paek SH Abstract Meningiomas are typically diagnosed by their characteristic appearance on conventional magnetic resonance imaging (MRI). However, detailed image findings regarding peri- and intra-tumoral anatomical structures, tumor consistency and vascularity are very important in pre-surgical planning and surgical outcomes. At the 7.0 T MRI achieving ultra-high resolution, it could be possible to obtain more useful information in surgical strategy. Four pat... περισσότερα »
Pseudo-obstruction, stroke and mitochondrial dysfunction
A lethal combination: [image: cover.gif?v=1&s=96f453ce2f3e9e0ae4ded563] ABSTRACT *Objectives*: The m.3243A>G *MTTL1* mutation is the most common cause of mitochondrial disease; yet there is limited awareness of intestinal pseudo-obstruction in this disorder. We aimed to determine the prevalence, severity and clinical outcome of patients with m.3243A>G-related mitochondrial disease manifesting with intestinal pseudo-obstruction. *Methods*: In this large, observational cohort study, we assessed the clinical, molecular and radiological characteristics of patients with genetically ... περισσότερα »
Invasive liver abscess syndrome caused by Klebsiella pneumoniae with definite K2 serotyping
in Japan: a case report: Background: Klebsiella pneumonia is a well-known human pathogen, and recently, a distinct invasive syndrome caused by K. pneumoniae serotypes K1 and K2 has been recognized in Southeast Asia. This syndrome is characterized by primary liver abscess and extrahepatic complications resulting from bacteremic dissemination. We report the first adult case of primary liver abscess caused by the definite K2 serotyped pathogen, with endogenous endophthalmitis in Japan.Case presentationA 64-year-old woman was admitted to a nearby hospital for a high fever and diarrhea.... περισσότερα »
Oxidative stability and microstructure of 5% fish-oil-enriched granola bars added natural antioxidants derived from brown alga Fucus vesiculosus
Oxidative stability and microstructure of 5% fish-oil-enriched granola bars added natural antioxidants derived from brown alga Fucus vesiculosus: Abstract The aims of this study were to; 1) investigate the ability of Icelandic brown algae *Fucus vesiculosus* extracts to inhibit lipid oxidation in granola bars fortified with fish oil-in-water emulsion; 2) investigate whether addition of the seaweed extracts affected the physical microstructure of the oil droplets in granola bars. The oxidative stability of the bars at 20°C was evaluated over a period of 10 weeks by measuring the deve... περισσότερα »
"J Korean Neurosurg Soc"[jour]; +17 new citations
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 23 δευτερόλεπτα
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *"J Korean Neurosurg Soc"[jour]* These pubmed results were generated on 2016/07/25 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/2a8cTEF via IFTTT http://ift.tt/2abo5AG
"J Korean Neurosurg Soc"[jour]; +17 new citations
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 23 δευτερόλεπτα
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *"J Korean Neurosurg Soc"[jour]* These pubmed results were generated on 2016/07/25 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. http://ift.tt/2a8cTEF http://ift.tt/29YZJH3
Reply to ‘Frontal Fibrosing Alopecia Severity Index (FFASI): a validated scoring system for assessing frontal fibrosing alopecia’: reply from the authors
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/29UwycI via IFTTT
Oxidative stability and microstructure of 5% fish-oil-enriched granola bars added natural antioxidants derived from brown alga Fucus vesiculosus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Oxidative stability and microstructure of 5% fish-oil-enriched granola bars added natural antioxidants derived from brown alga Fucus vesiculosus: Abstract The aims of this study were to; 1) investigate the ability of Icelandic brown algae Fucus vesiculosus extracts to inhibit lipid oxidation in granola bars fortified with fish oil-in-water emulsion; 2) investigate whether addition of the […]
Garlic oil reduces ruminal fatty acid biohydrogenation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
in vitro: Abstract Nutritional policies recommend that animal products should be made to contain more polyunsaturated FA, especially n-3 FA. This means finding ways to limit ruminal lipolysis and/or biohydrogenation. In pursuit of this goal, we performed an in vitro study to test the ability of four feed additives, typically used for other purposes, to […]
Silicon-containing phosphocholines (SiPCs)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
A Short Synthesis of Siloxane Phosphocholines: Abstract Herein we report our first generation synthesis of two new silicon-containing phosphocholines (SiPCs) in which the fatty acid chains are terminated by trisiloxane units. We have been exploring the limits to which immobilized lipases can be used in the field of organosilicon chemistry, and the cornerstone of this […]
Progress of Anatomical Sciences
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα
. Year *2016* Issue *03* is now available on CAOD. *In this issue:* shen qie huai nian chen yi ci jiao shou (深切怀念陈以慈教授) ...... page:235-236 Effects of Progesterone on the release of cytokines in culture supernatant of BV2 cells stimulated by Aβ1-42 and the viability of HT22 cells induced by the supernatant (外源性黄体酮对Aβ1-42诱导的小胶质细胞活化及其对海马神经元存活的影响) SONG Shu-lian, ZHOU Yan, ZHAO Chao, ZHOU Jie, JING Guo-liang, HAN Jing-jing , HUA Fang,Department of Neurology of the Affiliated Hospital, Xuzhou Medical University, Institute of Nervous System Diseases, Xuzhou Medical University, Key laborato... περισσότερα »
Alzheimer’s Disease and Cognitive Frailty: Novel Therapeutic Technologies
from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/2a9J5Fd via IFTTT
Two-dimensional discrete fractional Fourier transform-based content removal algorithm
Abstract This paper proposes a novel content removal technique for enhancing the camera identification performance. Here, very low bit rate videos with the overall noise patterns having time-varying statistics are considered. First, different two-dimensional discrete fractional Fourier transforms with different rotational angles are applied to the overall noise pattern of each frame of each video. Second, the modulus of each element of each transformed matrix is normalized to one if the rotational angles of the transforms are not equal to the integer multiples of \(\pi \) . Third, ... περισσότερα »
Bias extension test for pantographic sheets: numerical simulations based on second gradient shear energies
Abstract We consider a bi-dimensional sheet consisting of two orthogonal families of inextensible fibres. Using the representation due to Rivlin and Pipkin for admissible placements, i.e. placements preserving the lengths of the inextensible fibres, we numerically simulate a standard bias extension test on the sheet, solving a non-linear constrained optimization problem. Several first and second gradient deformation energy models are considered, depending on the shear angle between the fibres and on its gradient, and the results obtained are compared. The proposed numerical simulat... περισσότερα »
Gold-catalysed cross-coupling between aryldiazonium salts and arylboronic acids: probing the usefulness of photoredox conditions
[image: GA?id=C6CC04239B] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC04239B, Communication Thomas Cornilleau, Philippe Hermange, Eric Fouquet Combining gold catalysis and photoredox processes allowed the synthesis of biaryl compounds from diazonium salts and boronic acids under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/2aF6xez via IFTTT
Synthesis and Application of Hexagonal Perovskite BaNiO3 with Quadrivalent Nickel at Atmospheric and Low-Temperature Conditions
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC05704G, Communication Jin Goo Lee, Ho Jung Hwang, Ohchan Kwon, Ok Sung Jeon, Jeongseok Jang, Yong-Gun Shul A hexagonal perovskite BaNiO3 with unusual high-valence nickel (IV) was synthesized at atmospheric and low-temperature conditions by an ethylenediamine-derived wet-chemical route. Secondary phases disappeared with increase in pH value, and... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/2a864Tw via IFTTT
One-Step Ruthenium-Catalysed Transformation of 1,7-Enynes into Strained Bicyclic Amino Esters
The reaction of 1,7-enynes, synthesised from alpha-amino acids, carried out with diazo compounds in the presence of the Cp*RuCl(cod) catalyst allowed the one-step preparation of various strained bicyclic pipecolic acid derivatives in good yields under mild conditions. The stereoselectivity of the created double bond depends on the nature of the diazoalkane and the diastereoselectivity arises essentially from steric factors. from BioChemistry via xlomafota13 on Inoreader http://ift.tt/2a75YIl via IFTTT
Exchange Coupled Ferrite Nanocomposites through Chemical Synthesis
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC04911G, Communication Qilin Dai, Ketan Patel, Shenqiang Ren Exchange coupling between magnetically hard and soft phases has the promise to yield the large gain in energy product. In this work, we present a scalable chemical synthetic route to... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/2anLFfB via IFTTT
Synthesis, Separation and Absolute Configuration Determination by ECD Spectroscopy and TDDFT Calculations of 3-Amino-β-lactams and Derived Guanidines
Four isomeric chiral 3-amino-β-lactams *4* with *p*-fluorophenyl and *p*-methoxyphenyl substituents at N and C-4 positions, similar to the cholesterol absorption inhibitor ezetimibe, have been prepared as diastereomerically and enantiomerically pure compounds by ester enolate/imine cyclocondensation. The same route afforded analogues with a 1,3-benzodioxole instead of the *p*-methoxyphenyl group. Moreover, β-lactams *4a*,*b* were converted into benzoylguanidine derivatives. The series of chiral β-lactams and β-lactam guanidines was characterized by electronic circular dichroism (E... περισσότερα »
On the Photochemistry of 1,2-Benzisoxazole: Capture of Elusive Spiro-2H-azirine and Ketenimine Intermediates
The photochemistry of 1,2-benzisoxazole (*1*) was studied using low-temperature matrix isolation coupled with infrared spectroscopy and quantum chemistry calculations. We identified, for the first time, spiro-2 *H*-azirine *2* and ketenimine *3* as intermediates in the photoisomerization of *1* to 2-cyanophenol (*4*). These results constitute indirect evidence for the existence of vinylnitrene intermediates in the photochemistry of 1,2-benzisoxazoles. The potential energy surface (PES) resulting from the N–O bond cleavage of *1* was compared with the respective PES of the parent i... περισσότερα »
Bias extension test for pantographic sheets: numerical simulations based on second gradient shear energies
Abstract We consider a bi-dimensional sheet consisting of two orthogonal families of inextensible fibres. Using the representation due to Rivlin and Pipkin for admissible placements, i.e. placements preserving the lengths of the inextensible fibres, we numerically simulate a standard bias extension test on the sheet, solving a non-linear constrained optimization problem. Several first and second gradient deformation energy models are considered, depending on the shear angle between the fibres and on its gradient, and the results obtained are compared. The proposed numerical simulat... περισσότερα »
Stereoretentive H/D Exchange via an Electroactivated Heterogeneous Catalyst at sp3 C–H Sites Bearing Amines or Alcohols
This report describes a mild, aqueous-phase strategy that enables stereoretentive C–H activation at sp3 C–H sites bearing amine or alcohol groups. The transformation utilizes D2O to replace the hydrogen with deuterium while retaining stereochemistry. Electroactivated ruthenium particles, which are supported by an activated carbon cloth (Ru/ACC), catalyze this reaction on a timescale of minutes to hours. This yields optimal results at low current density and mild temperature. [image: Thumbnail image of graphical abstract] An electrocatalytic strategy is reported that allows stereo... περισσότερα »
On the effect of standard PFEM remeshing on volume conservation in free-surface fluid flow problems
Abstract The aim of this work is to analyze the remeshing procedure used in the particle finite element method (PFEM) and to investigate how this operation may affect the numerical results. The PFEM remeshing algorithm combines the Delaunay triangulation and the Alpha Shape method to guarantee a good quality of the Lagrangian mesh also in large deformation processes. However, this strategy may lead to local variations of the topology that may cause an artificial change of the global volume. The issue of volume conservation is here studied in detail. An accurate description of all t... περισσότερα »
Multiple Small Coronary Artery Fistulas Emptying into the Left Ventricle: A Rare but Challenging Problem
A coronary artery fistula (CAF) is an abnormal communication between a coronary artery and a cardiac chamber or a great vessel. CAFs are rare based on coronary arteriography and when found they most often empty into the right ventricle and atrium and less often into the high pressure, low compliance left ventricle (LV). A patient who presented with atypical chest pain and was found to have multiple small CAFs originating from the ramus intermedius coronary artery and emptying into the LV is presented. This case highlights the challenges in providing an appropriate therapy for mult... περισσότερα »
Progress of Anatomical Sciences
. Year *2016* Issue *03* is now available on CAOD. *In this issue:* shen qie huai nian chen yi ci jiao shou (深切怀念陈以慈教授) ...... page:235-236 Effects of Progesterone on the release of cytokines in culture supernatant of BV2 cells stimulated by Aβ1-42 and the viability of HT22 cells induced by the supernatant (外源性黄体酮对Aβ1-42诱导的小胶质细胞活化及其对海马神经元存活的影响) SONG Shu-lian, ZHOU Yan, ZHAO Chao, ZHOU Jie, JING Guo-liang, HAN Jing-jing , HUA Fang,Department of Neurology of the Affiliated Hospital, Xuzhou Medical University, Institute of Nervous System Diseases, Xuzhou Medical University, Key laborat... περισσότερα »
China Cancer
. Year *2016*Issue *07* is now available on CAOD. *In this issue:* An Analysis of Incidence and Mortality of Lung Cancer in the Registered Regions of Hunan,2009～2012 (2009～2012年湖南省肿瘤登记地区肺癌发病与死亡分析) LI Hao-si, LIAO Xian-zhen, LIANG Jiang-ping, Xiangya Hospital of Central South University, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Province Cancer Prevention and Cure Research Office ...... page:495-504 jian jue guan che zhi xing fa biao xue shu lun wen wu bu zhun gui ding (坚决贯彻执行《发表学术论文"五不准"》规定) ...... page:504 A... περισσότερα »
Modern antiematogenic therapy from 5-H3T to NK-1 antagonists
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Dr Lavasani speaks with ecancertv at the Best of ASCO 2016 about limiting the risk of nausea as a result of chemotherapy. She describes results from international teams, including adjuvant rolapitant and the impact of reduced dexamethasone… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29ZWlMI via IFTTT
A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responses in vitro
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Purified microglial cells in culture are frequently used to model brain inflammatory responses but obtaining large yields of these cells on a routine basis can be quite challenging. Here, we demonstrate that it is possible to achieve high-yield isolation of pure microglial (MAC-1+/Fcrls+/Ccr2-) cells from postnatal brain tissue through a simple culture procedure that mainly […]
Oxidative Stress as Estimated by Gamma-Glutamyl Transferase Levels Amplifies the Alkaline Phosphatase-Dependent Risk for Mortality in ESKD Patients on Dialysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Alkaline phosphatase (Alk-Phos) is a powerful predictor of death in patients with end-stage kidney disease (ESKD) and oxidative stress is a strong inducer of Alk-Phos in various tissues. We tested the hypothesis that oxidative stress, as estimated by a robust marker of systemic oxidative stress like γ-Glutamyl-Transpeptidase (GGT) levels, may interact with Alk-Phos in the […]
Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Objective. To investigate the risk factors, clinical characteristics, treatment modalities, and outcomes in Saudi patients with HCC and propose points for early detection of the disease. Methods. Patients were stratified according to underlying risk factors for the development of HCC. Barcelona Clinic Liver Cancer (BCLC) was used for cancer staging. Treatment was classified into surgical […]
Alzheimer’s Disease and Cognitive Frailty: Novel Therapeutic Technologies
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2a9J5Fd via IFTTT
Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Objective. It has been testified that iodine regulates thyroid function by controlling thyroid-restricted genes expression and is closely related to diffuse goiter and thyroid dysfunction. However, the effects of follicular lumen iodine, the main form of iodine reserve in the body, on thyroid-restricted genes in nodular goiter are poorly understood. In this study, correlations between […]
Parametric Study of Fuel Distribution Effects on a Kerosene-Based Scramjet Combustor
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Generally, the overall performance of scramjet combustor is greatly impacted by the fuel distribution scheme. The current paper mainly conducted a comprehensive parametric study of the impact of fuel distribution on the overall performance of a kerosene-based scramjet combustor. Herein, a 3D supersonic combustor with a recessed cavity and four injection orifices was taken into […]
Modeling Based Characterization of Thermorheological Properties of Polyurethane ESTANE™
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Shape-Memory Polymers (SMPs) have the ability to be deformed and memorize this deformation until an external activation stimulus (e.g., heat) is applied. Therefore, they have attracted great interest in many areas, especially for applications where reconfigurable structures are required (e.g., Shape-Memory (SM) stents or micro air vehicles). Nevertheless, prior to technical application, the effective thermomechanical […]
An Adaptive Dynamic Surface Controller for Ultralow Altitude Airdrop Flight Path Angle with Actuator Input Nonlinearity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
In the process of ultralow altitude airdrop, many factors such as actuator input dead-zone, backlash, uncertain external atmospheric disturbance, and model unknown nonlinearity affect the precision of trajectory tracking. In response, a robust adaptive neural network dynamic surface controller is developed. As a result, the aircraft longitudinal dynamics with actuator input nonlinearity is derived; the […]
The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Asthma is characterized by reversible airway narrowing, shortness of breath, wheezing, coughing, and other symptoms driven by chronic inflammatory processes, commonly triggered by allergens. In 90% of asthmatics, most of these symptoms can also be triggered by intense physical activities and severely exacerbated by environmental factors. This condition is known as exercise-induced asthma (EIA). Current […]
Comparative analysis of biologic versus synthetic mesh outcomes in contaminated hernia repairs
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
Surgery from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a88W2s via IFTTT
Useful condition of chromoendoscopy with indigo carmine and acetic acid for identifying a demarcation line prior to endoscopic submucosal dissection for early gastric cancer
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
BMC Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a7cu1U via IFTTT
UVM clinical trials lead to first FDA approved cholera vaccine in U.S.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
University of Vermont Health & Medicine News from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a88z8q via IFTTT
Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
Journal of Surgical Oncology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a7bzOQ via IFTTT
The current status of emergent laparoscopic colectomy: A population-based study of clinical and financial outcomes
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
Surgical Endoscopy from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a88Vvq via IFTTT
Long-term follow-up results of endoscopic treatment of gastroesophageal reflux disease with the MUSE endoscopic stapling device
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
Surgical Endoscopy from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a7ccIl via IFTTT
Routine extra-hepatic bile duct resection in gallbladder cancer patients without bile duct infiltration: A systematic review
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
The Surgeon from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a886mx via IFTTT
Hepatic encephalopathy in patients with non-cirrhotic portal hypertension: Description, prevalence and risk factors
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 58 δευτερόλεπτα
Digestive and Liver Diseases from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a7bESI via IFTTT
Adjuvant chemotherapy in early-stage colon cancer may improve survival
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
University of Illinois at Chicago Health News from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a88wcC via IFTTT
Changes in metabolic hormones after bariatric surgery and their predictive impact on weight loss
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Clinical Endocrinology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a7cFKr via IFTTT
CNIO researchers describe inflammatory mechanisms linked to liver cancer
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Centro Nacional de Investigaciones Oncologicas News from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2a88MbH via IFTTT
OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
While OPN is an important mediator of muscle remodeling in health and disease, functional differences in human spliced OPN variants in the muscle microenvironment have not been characterized. We thus sought to define the pro-inflammatory activities of human OPN isoforms (OPN-a, OPN-b, and OPN-c) on cells present in regenerating muscle. OPN transcripts were quantified in normal and dystrophic human and dog muscle. Human macrophages and myoblasts were stimulated with recombinant human OPN protein isoforms and cytokine mRNA and protein induction was assayed. OPN isoforms were greatly... περισσότερα »
The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma
Asthma is characterized by reversible airway narrowing, shortness of breath, wheezing, coughing, and other symptoms driven by chronic inflammatory processes, commonly triggered by allergens. In 90% of asthmatics, most of these symptoms can also be triggered by intense physical activities and severely exacerbated by environmental factors. This condition is known as exercise-induced asthma (EIA). Current theories explaining EIA pathogenesis involve osmotic and/or thermal alterations in the airways caused by changes in respiratory airflow during exercise. These changes, along with ex... περισσότερα »
Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials
Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review... περισσότερα »
Epidermal Growth Factor and Intestinal Barrier Function
Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier ... περισσότερα »
Progression of Friedreich ataxia: quantitative characterization over 5 years
Abstract Objective Friedreich ataxia (FRDA) is a progressive neurodegenerative disorder of adults and children. This study analyzed neurological outcomes and changes to identify predictors of progression and generate power calculations for clinical trials. Methods Eight hundred and twelve subjects in a natural history study were evaluated annually across 12 sites using the Friedreich Ataxia Rating Scale (FARS), 9-Hole Peg Test, Timed 25-Foot Walk, visual acuity tests, self-reported surveys and disability scales. Cross-sectional outcomes were assessed from recent visits, and long... περισσότερα »
Terminal complement activation is increased and associated with disease severity in CIDP
Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common chronic autoimmune neuropathy. While both cell-mediated and humoral mechanisms contribute to its pathogenesis, the rapid clinical response to plasmapheresis implicates a circulating factor responsible for peripheral nerve injury. We report that treatment-naïve patients with CIDP show increased serum and CSF levels of the anaphylatoxin C5a and the soluble terminal complement complex (sTCC). Systemic terminal complement activation correlates with clinical disease severity as determined by the Inflamm... περισσότερα »
Cerebellar output encodes a corrective motor command
Abstract The integrity of the cerebellum is critical for accurate eye movements. Disruption of neurons in either the cerebellar oculomotor vermis or its projections to output nucleus of the cerebellum, the caudal fastigial nucleus (cFN), results in significant saccadic dysmetria (Goffart et al., 2004; Ohtsuka et al., 1994; Ritchie, 1976; Buzunov et al. 2013). The relationship between cFN neuron firing rates and saccade kinematic parameters is quite variable across neurons (Hepp et al., 1982; Fuchs et al., 1993), suggesting that a direct encoding of saccade parameters may not occur... περισσότερα »
Spatially resolved time-frequency analysis of odour coding in the insect antennal lobe
Abstract Antennal lobes constitute the first neurophils in the insect brain involved in coding and processing of olfactory information. With their stereotyped functional and anatomical organization, they provide an accessible model with which to investigate information processing of an external stimulus in a neural network *in vivo*. Here, by combining functional calcium imaging with time-frequency analysis, we have been able to monitor the oscillatory components of neural activity upon olfactory stimulation. The aim of the present study is to investigate the presence of stimulus-i... περισσότερα »
Cocaine abstinence induces emotional impairment and brain region-specific upregulation of the oxytocin receptor binding
Abstract The key problem in treating cocaine addiction is the maintenance of a drug-free state since negative emotional symptoms during abstinence often trigger relapse. The mechanisms underpinning the emotional dysregulation during abstinence are currently not well-understood. There is evidence suggesting a role of the neuropeptide oxytocin in the modulation of drug addiction processes. However, its involvement during long-term abstinence from cocaine use remains unclear. In this study, we aimed to behaviourally characterize a mouse model of long-term cocaine withdrawal and assess... περισσότερα »
Downregulation of HMGB1 by miR-34a is sufficient to suppress proliferation, migration and invasion of human cervical and colorectal cancer cells
Abstract High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein known to be highly expressed in human cervical (CaCx) and colorectal (CRC) cancers, and sustained high levels of HMGB1 contribute to tumourigenesis and metastasis. *HMGB1*-targeted cancer therapy is of recent interest, and there are not many studies on miRNA-mediated *HMGB1* regulation in these cancers. Since miRNA-based therapeutics for cancer is gaining importance in recent years, it was of interest to predict miRNAs targeting *HMGB1*. Based on the identification of a potential *miR-34a* response element i... περισσότερα »
MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha
Abstract Metastasis has become the main challenge for treatment of estrogen receptor alpha (ERα) negative breast cancer. Here, we found a negative correlation between miR-497 and estrogen-related receptor alpha (ERRα), a nuclear receptor overexpressed in ERα negative breast cancer. Targeted inhibition of ERRα by si-RNA increased miR-497 expression while overexpression of ERRα inhibited miR-497 expression. Further investigation showed that miR-497 targeted ERRα by binding to the 3′UTR region of ERRα. Luciferase assay and ChIP assay confirmed that ERα directly regulated the transcrip... περισσότερα »
Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer
Abstract In this work, the in vitro experiments about biological mechanisms of curcumin were conducted using the gastric cancer cell lines SGC-7901 and BGC-823. After 24-h exposure to curcumin at the concentrations of 5, 10, 15, 20, and 40 μmol/L, two cells showed the decreased proliferation and increased apoptosis abilities. Real-time PCR, Cell Counting Kit-8 (CCK-8) assay, western blotting, and cell apoptosis assay were used to further study the underlying mechanisms of curcumin. The first stage of our studies showed that curcumin affected the expression of miR-33b, which, in tur... περισσότερα »
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
Abstract The spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The ubiquitin-specific protease 39 (USP39) is essential for pre-mRNA splicing, and upregulated USP39 expression is noted in a variety of cancers. However, the role of USP39 in the development and progression of melanoma remains unclear. In the present study, USP39 expression was found to be inc... περισσότερα »
Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer
Abstract Recent evidence indicates the involvement of calpains (CAPNs), a family of cysteine proteases, in cancer development and progression, as well as the insufficient response to cancer therapies. The contribution of CAPNs and regulatory calpastatin (CAST) and ERK1/2 kinases to aggressiveness, disease course, and outcome in laryngeal cancer remains elusive. This study was aimed to evaluate the CAPN1/2-CAST-ERK1/2 enzyme system mRNA/protein level and to investigate whether they can promote the dynamic of tumor growth and prognosis. The mRNA expression of marker genes was determi... περισσότερα »
Table of Contents
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/29YRMSg
Editorial Board Page
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/2abgAK8
AAOMS Author Disclosure forms
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/2abfLRD
Help Us Remember Our History
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): James R. Hupp http://ift.tt/29YRv1D
Clinical Focus - Crestal Approach for Sinus Floor Augmentation
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Michael S. Block http://ift.tt/29YRWZC
Masthead
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/2abg2Uj
More than Bisphosphonates
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): M. Anthony Pogrel http://ift.tt/2abgbqV
News and Announcements
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 http://ift.tt/29YRUB7
A Novel Method of Orbital Floor Reconstruction Using Virtual Planning, 3-Dimensional Printing, and Autologous Bone
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Maarten Vehmeijer, Maureen van Eijnatten, Niels Liberton, Jan Wolff Fractures of the orbital floor are often a result of traffic accidents or interpersonal violence. To date, numerous materials and methods have been used to reconstruct the orbital floor. However, simple and cost-effective 3-dimensional (3D) printing technologies for the treatment of orbital floor fractures are still sought. This study describes a simple, precise, cost-effective method of treating orbital f... περισσότερα »
Efficacy of Retromandibular Transparotid Approach for the Management of Extracapsular Subcondylar Mandibular Fractures Using 2-mm Titanium Miniplates: A Prospective Clinical Study
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Narotam Kumar Ghezta, Yogesh Bhardwaj, Pooja Rani, Rangila Ram PurposeThe aim of this study was to evaluate the long-term clinical and radiologic results of the retromandibular transparotid approach to displaced extracapsular subcondylar mandibular fractures.Patients and MethodsA prospective cohort study was conducted over a period of 5 years on patients surgically treated for displaced extracapsular subcondylar mandibular fractures by the retromandibular transparotid appro... περισσότερα »
Effects of radiation on the temporal bone in patients with head and neck cancer
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Abstract Radiotherapy is a key component in the treatment of many head and neck cancers, and its potential to cause long-term adverse effects has become increasingly recognized. In this review, we describe the short-term and long-term sequelae of radiation-associated changes in and injury to the temporal bone and its related structures. The pathophysiology of radiation-induced injury and its clinical entities, including sensorineural hearing loss, chronic otitis media, osteoradionecrosis, and radiation-associated malignancies, are described. We also discuss radiation dose to the h... περισσότερα »
Retrospective analysis of factors influencing oncologic outcome in 590 patients with early-intermediate glottic cancer treated by transoral laser microsurgery
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
[image: cover.gif?v=1&s=f302950f6434daecbd65a56c] Abstract Background The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM). Methods This was a retrospective mono-institutional study. A total of 590 patients with cTis-cT3 glottic cancer underwent TLM with curative intent. Results TLM alone was performed in 538 patients (91.2%) and TLM followed by adjuvant radiotherapy (RT) was done in 52 (8.8%). Five-year recurrence-free survival (RFS) and 10-year overa... περισσότερα »
Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: Available online 22 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Arthur F. Gelb, Jay A. Nadel http://ift.tt/2a5dbyW
Editor’s Choice for July 2016
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Prof Gordon McVie provides highlights from ecancer for July 2016: Events ecancer’s Future Horizons in Lung Cancer event Highlights from the first International ecancer Conference on Oncology and Radiotherapy, 6–7 May 2016, Santiago,… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2ad7H3D via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Modern antiematogenic therapy from 5-H3T to NK-1 antagonists
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Dr Lavasani speaks with ecancertv at the Best of ASCO 2016 about limiting the risk of nausea as a result of chemotherapy. She describes results from international teams, including adjuvant rolapitant and the impact of reduced dexamethasone… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ZWlMI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 […]
A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responses in vitro
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Purified microglial cells in culture are frequently used to model brain inflammatory responses but obtaining large yields of these cells on a routine basis can be quite challenging. Here, we demonstrate that it is possible to achieve high-yield isolation of pure microglial (MAC-1+/Fcrls+/Ccr2-) cells from postnatal brain tissue through a simple culture procedure that mainly […]
Eldre bør behandles som yngre
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
En norsk studie viser at eldre med hjerteinfarkt kan ha stor nytte av invasiv behandling i tillegg til annen medisinsk behandling. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ZWAaT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Over 80 år og hjerteinfarkt
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
I europeiske retningslinjer anbefales rask invasiv koronarutredning ved akutt koronarsyndrom uten ST-elevasjon. Nytten av slik utredning hos de eldste har inntil nylig vært dårlig dokumentert. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2ad7OvU via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reply to ‘Frontal Fibrosing Alopecia Severity Index (FFASI): a validated scoring system for assessing frontal fibrosing alopecia’: reply from the authors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29UwycI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Effects of radiation on the temporal bone in patients with head and neck cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Radiotherapy is a key component in the treatment of many head and neck cancers, and its potential to cause long-term adverse effects has become increasingly recognized. In this review, we describe the short-term and long-term sequelae of radiation-associated changes in and injury to the temporal bone and its related structures. The pathophysiology of radiation-induced […]
Retrospective analysis of factors influencing oncologic outcome in 590 patients with early-intermediate glottic cancer treated by transoral laser microsurgery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM). Methods This was a retrospective mono-institutional study. A total of 590 patients with cTis-cT3 glottic cancer underwent TLM with curative intent. Results TLM alone was performed in 538 […]
Cosmetics, Vol. 3, Pages 27: Overview of Skin Whitening Agents: Drugs and Cosmetic Products
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Depigmentation and skin lightening products, which have been in use for ages in Asian countries where skin whiteness is a major esthetic criterion, are now also highly valued by Western populations, who expose themselves excessively to the sun and develop skin spots as a consequence. After discussing the various possible mechanisms of depigmentation, the different […]
FFR-CT makes the grade in clinical practice
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Using fractional flow reserve CT (FFR-CT) to assess the severity of coronary… Read more on AuntMinnieEurope.com Related Reading: CT myocardial perfusion imaging evolves HeartFlow highlights FFR study at EuroPCR 2016 CT technique can reduce invasive heart tests HeartFlow promotes FFR study at EuroPCR Rotterdam group helps gauge coronary disease severity from #ORL-AlexandrosSfakianakis via simeraentaxei on […]
Labeled Immunoassays and Clinical Medicine
. Year *2016* Issue *05* is now available on CAOD. *In this issue:* Retrospective Analysis of Subclinical Hypothyroidism and Metabolic Syndrome (亚临床甲状腺功能减低症与代谢综合征组分相关性的研究) WANG Ming-hui, ,GUO Guang-hong ...... page:477-479,528 The Variation of Surum FT3, FT4, TT3, TT4 and TSH in During Pregnancy as Reference of Thyroid Function in Pregnant Women (妊娠期血清中FT3、FT4、TT3、TT4和TSH的变化范围对孕妇甲状腺功能诊断的参考) MA Ya-hui, ,WANG Li, ,YAN Xiao-ying ...... page:480-483 Levothyroxine Dosage and Influential Factors in the Treatment of Subclinical Hypothyroidism in Pregnant Women (亚临床甲状腺功能减退症孕妇左旋甲状腺素治疗剂量及影响因素... περισσότερα »
Downregulation of HMGB1 by miR-34a is sufficient to suppress proliferation, migration and invasion of human cervical and colorectal cancer cells
Abstract High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein known to be highly expressed in human cervical (CaCx) and colorectal (CRC) cancers, and sustained high levels of HMGB1 contribute to tumourigenesis and metastasis. *HMGB1*-targeted cancer therapy is of recent interest, and there are not many studies on miRNA-mediated *HMGB1* regulation in these cancers. Since miRNA-based therapeutics for cancer is gaining importance in recent years, it was of interest to predict miRNAs targeting *HMGB1*. Based on the identification of a potential *miR-34a* response element i... περισσότερα »
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
Abstract The spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The ubiquitin-specific protease 39 (USP39) is essential for pre-mRNA splicing, and upregulated USP39 expression is noted in a variety of cancers. However, the role of USP39 in the development and progression of melanoma remains unclear. In the present study, USP39 expression was found to be inc... περισσότερα »
MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha
Abstract Metastasis has become the main challenge for treatment of estrogen receptor alpha (ERα) negative breast cancer. Here, we found a negative correlation between miR-497 and estrogen-related receptor alpha (ERRα), a nuclear receptor overexpressed in ERα negative breast cancer. Targeted inhibition of ERRα by si-RNA increased miR-497 expression while overexpression of ERRα inhibited miR-497 expression. Further investigation showed that miR-497 targeted ERRα by binding to the 3′UTR region of ERRα. Luciferase assay and ChIP assay confirmed that ERα directly regulated the transcrip... περισσότερα »
Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer
Abstract In this work, the in vitro experiments about biological mechanisms of curcumin were conducted using the gastric cancer cell lines SGC-7901 and BGC-823. After 24-h exposure to curcumin at the concentrations of 5, 10, 15, 20, and 40 μmol/L, two cells showed the decreased proliferation and increased apoptosis abilities. Real-time PCR, Cell Counting Kit-8 (CCK-8) assay, western blotting, and cell apoptosis assay were used to further study the underlying mechanisms of curcumin. The first stage of our studies showed that curcumin affected the expression of miR-33b, which, in tur... περισσότερα »
Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer
Abstract Recent evidence indicates the involvement of calpains (CAPNs), a family of cysteine proteases, in cancer development and progression, as well as the insufficient response to cancer therapies. The contribution of CAPNs and regulatory calpastatin (CAST) and ERK1/2 kinases to aggressiveness, disease course, and outcome in laryngeal cancer remains elusive. This study was aimed to evaluate the CAPN1/2-CAST-ERK1/2 enzyme system mRNA/protein level and to investigate whether they can promote the dynamic of tumor growth and prognosis. The mRNA expression of marker genes was determi... περισσότερα »
Cyclic-Protected Hexafluoroacetone as an Air-Stable Liquid Reagent for Trifluoromethylations
An air-stable liquid trifluoromethylating reagent is readily synthesized from gaseous hexafluoroacetone and 2-methylproline on a gram scale. The reaction of the trifluoromethylating reagent with *tert*-butoxy cuprate K[Cu(O*t*Bu)2] leads to the CuCF3 in high yield. This species is directly formed from the tetrahedral cuprate intermediate through intramolecular migration of the trifluoromethyl group to copper. The CuCF3 reagent prepared in situ by our method can be used for the trifluoromethylation of aryl iodides, arylboronic acids, and terminal alkynes in good to excellent yield... περισσότερα »
DEM modeling of ball mills with experimental validation: influence of contact parameters on charge motion and power draw
Abstract Discrete element method simulations of a 1:5-scale laboratory ball mill are presented in this paper to study the influence of the contact parameters on the charge motion and the power draw. The *position density limit* is introduced as an efficient mathematical tool to describe and to compare the macroscopic charge motion in different scenarios, i.a. with different values of the contact parameters. While the charge motion and the power draw are relatively insensitive to the stiffness and the damping coefficient of the linear spring-slider-damper contact law, the coefficien... περισσότερα »
Diastereoselective Synthesis of Pyranoquinolines on Zirconium-Containing UiO-66 Metal-Organic Frameworks
The Zr terephthalate MOFs UiO-66 and UiO-66-NH2 have been found to be highly diastereoselective catalysts for the synthesis of a pyrano[3,2-*c*]quinoline through an inverse electron-demand aza-Diels–Alder [4+2] cycloaddition of an aryl imine (formed in situ from aniline and benzaldehyde) and 3,4-dihydro-2*H*-pyran in one pot, affording the corresponding *trans* isomer in diastereomeric excesses of 90–95 %. The solids are stable under the reaction conditions and can be reused at least three times without significant loss of activity or diastereoselectivity. [image: Thumbnail image ... περισσότερα »
Genotypes-Independent Optimization of Nitrogen Supply for Isolated Microspore Cultures in Barley
To establish a high-efficiency system of isolated microspore culture for different barley genotypes, we investigated the effects of nitrogen sources and concentrations on callus induction and plant regeneration in different barley genotypes. The results showed that the organic nitrogen sources greatly increased the callus induction, and the great reduction of total nitrogen sources would significantly decrease the callus induction. And the further optimization experiments revealed that the increasing of organic nitrogen sources was much important in callus induction while it seemed... περισσότερα »
On the effect of standard PFEM remeshing on volume conservation in free-surface fluid flow problems
Abstract The aim of this work is to analyze the remeshing procedure used in the particle finite element method (PFEM) and to investigate how this operation may affect the numerical results. The PFEM remeshing algorithm combines the Delaunay triangulation and the Alpha Shape method to guarantee a good quality of the Lagrangian mesh also in large deformation processes. However, this strategy may lead to local variations of the topology that may cause an artificial change of the global volume. The issue of volume conservation is here studied in detail. An accurate description of all t... περισσότερα »
DEM modeling of ball mills with experimental validation: influence of contact parameters on charge motion and power draw
Abstract Discrete element method simulations of a 1:5-scale laboratory ball mill are presented in this paper to study the influence of the contact parameters on the charge motion and the power draw. The *position density limit* is introduced as an efficient mathematical tool to describe and to compare the macroscopic charge motion in different scenarios, i.a. with different values of the contact parameters. While the charge motion and the power draw are relatively insensitive to the stiffness and the damping coefficient of the linear spring-slider-damper contact law, the coefficien... περισσότερα »
Frequency domain analysis of cerebral near infrared spectroscopy signals during application of an impedance threshold device in spontaneously ventilating volunteers
Abstract Currently available near infrared spectroscopy (NIRS) devices are unable to discriminate between arterial and venous blood, a potential source of artifact. The purpose of this study was to test the hypothesis that oscillations in NIR signals at the respiratory and cardiac frequency could be attributed to venous and arterial blood, respectively, and thereby isolated. After written informed consent was obtained, a two-wavelength NIRS device was placed over the left frontal cortex in 20 volunteers. After 5 min of unimpeded spontaneous ventilation, an impedance threshold devic... περισσότερα »
The comparison of the technical parameters in endotracheal intubation devices: the Cmac, the Vividtrac, the McGrath Mac and the Kingvision
Abstract Currently, there are plenty of videolaryngoscopes that appear on the market. They have different specifications. Some of these features favor the fact that they are more suited for educational purposes of future operators and others can be characterized with an excellent clinical use. In this study we compared four types of videolaryngoscopes. The aim of the study was to compare the technical specifications of the above-mentioned devices for usefulness in clinical practice and correlate these parameters with the subjective evaluation of these videolaryngoscopes usage perfo... περισσότερα »
Role of cerebral oxygenation for prediction of hypotension after spinal anesthesia for caesarean section
Abstract To investigate the role of cerebral oxygen saturation (ScO2) for prediction of hypotension after spinal anesthesia for caesarean section. Forty-five parturients undergoing elective caesarean section under spinal anesthesia were selected. Blood pressure, heart rate and pulse oxygen saturation before and after anesthesia were recorded, and the association between changes in ScO2 before and after anesthesia with hypotension after spinal anesthesia was explored. Hypotension occurred in 32 parturients after spinal anesthesia. The decrease in ScO2 after spinal anesthesia in par... περισσότερα »
Evaluation of transcutaneous and end-tidal carbon dioxide levels during inhalation sedation in volunteers
Abstract Measurement of end-tidal carbon dioxide (PETCO2) is useful because of its noninvasiveness, continuity, and response time when sudden changes in ventilation occur during inhalation sedation. We compared the accuracy of P ETCO2 using a nasal mask and nasal cannula with the accuracy of transcutaneous carbon dioxide (TC-CO2) and determined which method is more useful during inhalation sedation in volunteers. We used a modified nasal mask (MNM) and modified nasal cannula (MNC) for measurement of PETCO2. The capnometer measured PETCO2 in the gas expired from the nasal cavity by ... περισσότερα »
Variability of FeNO in healthy subjects at 2240 meters above sea level
Abstract Fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic airway inflammation. Altitude above sea level can affect measurements of this index, but there is only limited information regarding the diurnal variation (ante meridiem vs. post meridiem) and reproducibility of FeNO on consecutive days at moderate altitudes. To evaluate the diurnal variability of FeNO and assess its reproducibility over five consecutive days in healthy individuals living at 2240 m, and to compare the FeNO readings taken with two different analyzers. Healthy non-smoking adults were measur... περισσότερα »
Diagnostic accuracy of stroke volume variation measured with uncalibrated arterial waveform analysis for the prediction of fluid responsiveness in patients with impaired left ventricular function: a prospective, observational study
Abstract Uncalibrated arterial waveform analysis enables dynamic preload assessment in a minimally invasive fashion. Evidence about the validity of the technique in patients with impaired left ventricular function is scarce, while adequate cardiac preload assessment would be of great value in these patients. The aim of this study was to investigate the diagnostic accuracy of stroke volume variation (SVV) measured with the FloTrac/Vigileo™ system in patients with impaired left ventricular function. In this prospective, observational study, 22 patients with a left ventricular ejectio... περισσότερα »
A mainstream monitoring system for respiratory CO 2 concentration and gasflow
Abstract Continuous respiratory gas monitoring is an important tool for clinical monitoring. In particular, measurement of respiratory \(\hbox {CO}_2\) concentration and gasflow can reflect the status of a patient by providing parameters such as volume of carbon dioxide, end-tidal \(\hbox {CO}_2,\) respiratory rate and alveolar deadspace. However, in the majority of previous work, \(\hbox {CO}_2\) concentration and gasflow have been studied separately. This study focuses on a mainstream system which simultaneously measures respiratory \(\hbox {CO}_2\) concentration and gasflow at t... περισσότερα »
Comparison of electrical velocimetry and cardiac magnetic resonance imaging for the non-invasive determination of cardiac output
Abstract A novel algorithm of impedance cardiography referred to as electrical velocimetry (EV) has been introduced for non-invasive determination of cardiac output (CO). Previous validation studies yielded diverging results and no comparison with the non-invasive gold standard cardiac magnetic resonance imaging (CMR) has been performed. We therefore aimed to prospectively assess the accuracy and reproducibility of EV compared to CMR. 152 consecutive stable patients undergoing CMR were enrolled. EV measurements were taken twice before or after CMR in supine position and averaged o... περισσότερα »
Comparison of an advanced minimally invasive cardiac output monitoring with a continuous invasive cardiac output monitoring during lung transplantation
Abstract The aim of this study was to compare a continuous non-calibrated left heart cardiac index (CI) measurement by arterial waveform analysis (FloTrac® /Vigileo®) with a continuous calibrated right heart CI measurement by pulmonary artery thermodilution (CCOmbo-PAC®/Vigilance II®) for hemodynamic monitoring during lung transplantation. CI was measured simultaneously by both techniques in 13 consecutive lung transplants (n = 4 single-lung transplants, n = 9 sequential double-lung transplants) at distinct time points perioperatively. Linear regression analysis and Bland–Altman an... περισσότερα »
The effect of low-dose dexmedetomidine on hemodynamics and anesthetic requirement during bis-spectral index-guided total intravenous anesthesia
Abstract The purpose of this study was to evaluate the effects of low-dose dexmedetomidine on hemodynamics and anesthetic requirements during propofol and remifentanil anesthesia for laparoscopic cholecystectomy. Thirty adult patients were randomly allocated to receive dexmedetomidine infusion of 0.3 μg/kg/h (dexmedetomidine group, n = 15) or comparable volumes of saline infusion (control group, n = 15). Target controlled infusion of propofol and remifentanil was used for anesthetic induction and maintenance, and adjusted in order to maintain a bispectral index of 40–55 and hemodyn... περισσότερα »
A comparison of different synchronization measures in electroencephalogram during propofol anesthesia
Abstract Electroencephalogram (EEG) synchronization is becoming an essential tool to describe neurophysiological mechanisms of communication between brain regions under general anesthesia. Different synchronization measures have their own properties to reflect the changes of EEG activities during different anesthetic states. However, the performance characteristics and the relations of different synchronization measures in evaluating synchronization changes during propofol-induced anesthesia are not fully elucidated. Two-channel EEG data from seven volunteers who had undergone a b... περισσότερα »
The relationship between the Bispectral Index (BIS) and the Observer Alertness of Sedation Scale (OASS) scores during propofol sedation with and without ketamine: a randomized, double blinded, placebo controlled clinical trial
Abstract Prior studies have examined the static effect of intravenous ketamine on the BIS Index for sedation but it remains unknown if the BIS Index is a reliable method to track sedation levels in the presence of ketamine. The major objective of the current investigation was to compare the BIS Vista Index ability to track varying depths of sedation as determined by OASS scores in a standardized anesthetic regimen with and without ketamine. The study was a randomized, double blinded clinical trial. Patients undergoing breast surgery under sedation with propofol were randomized to r... περισσότερα »
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
Abstract The spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The ubiquitin-specific protease 39 (USP39) is essential for pre-mRNA splicing, and upregulated USP39 expression is noted in a variety of cancers. However, the role of USP39 in the development and progression of melanoma remains unclear. In the present study, USP39 expression was found to be inc... περισσότερα »
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
Abstract The spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The ubiquitin-specific protease 39 (USP39) is essential for pre-mRNA splicing, and upregulated USP39 expression is noted in a variety of cancers. However, the role of USP39 in the development and progression of melanoma remains unclear. In the present study, USP39 expression was found to be incr... περισσότερα »
Progress of Anatomical Sciences
. Year *2016* Issue *03* is now available on CAOD. *In this issue:* shen qie huai nian chen yi ci jiao shou (深切怀念陈以慈教授) ...... page:235-236 Effects of Progesterone on the release of cytokines in culture supernatant of BV2 cells stimulated by Aβ1-42 and the viability of HT22 cells induced by the supernatant (外源性黄体酮对Aβ1-42诱导的小胶质细胞活化及其对海马神经元存活的影响) SONG Shu-lian, ZHOU Yan, ZHAO Chao, ZHOU Jie, JING Guo-liang, HAN Jing-jing , HUA Fang,Department of Neurology of the Affiliated Hospital, Xuzhou Medical University, Institute of Nervous System Diseases, Xuzhou Medical University, Key laborato... περισσότερα »
Progress of Anatomical Sciences
. Year *2016* Issue *03* is now available on CAOD. *In this issue:* shen qie huai nian chen yi ci jiao shou (深切怀念陈以慈教授) ...... page:235-236 Effects of Progesterone on the release of cytokines in culture supernatant of BV2 cells stimulated by Aβ1-42 and the viability of HT22 cells induced by the supernatant (外源性黄体酮对Aβ1-42诱导的小胶质细胞活化及其对海马神经元存活的影响) SONG Shu-lian, ZHOU Yan, ZHAO Chao, ZHOU Jie, JING Guo-liang, HAN Jing-jing , HUA Fang,Department of Neurology of the Affiliated Hospital, Xuzhou Medical University, Institute of Nervous System Diseases, Xuzhou Medical University, Key laborat... περισσότερα »
Nonlinear Absorptions of CdSeTe Quantum Dots under Ultrafast Laser Radiation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The oil-soluble alloyed CdSeTe quantum dots (QDs) are prepared by the electrostatic method. The basic properties of synthesized CdSeTe QDs are characterized by UV-Vis absorption spectroscopy, photoluminescence spectroscopy, inductively coupled plasma mass spectrometry, and transmission electron microscope. The off-resonant nonlinear optical properties of CdSeTe QDs are studied by femtosecond Z-scan at 1 kHz (low-repetition rate) and […]
A Dynamic Model of Human and Livestock Tuberculosis Spread and Control in Urumqi, Xinjiang, China
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We establish a dynamical model for tuberculosis of humans and cows. For the model, we firstly give the basic reproduction number . Furthermore, we discuss the dynamical behaviors of the model. By epidemiological investigation of tuberculosis among humans and livestock from 2007 to 2014 in Urumqi, Xinjiang, China, we estimate the parameters of the model […]
Clinical Focus - Crestal Approach for Sinus Floor Augmentation
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Michael S. Block from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29YRWZC via IFTTT
More than Bisphosphonates
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): M. Anthony Pogrel from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/2abgbqV via IFTTT
News and Announcements
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29YRUB7 via IFTTT
A Novel Method of Orbital Floor Reconstruction Using Virtual Planning, 3-Dimensional Printing, and Autologous Bone
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Maarten Vehmeijer, Maureen van Eijnatten, Niels Liberton, Jan Wolff Fractures of the orbital floor are often a result of traffic accidents or interpersonal violence. To date, numerous materials and methods have been used to reconstruct the orbital floor. However, simple and cost-effective 3-dimensional (3D) printing technologies for the treatment of orbital floor fractures are still sought. This study describes a simple, precise, cost-effective method of treating orbital f... περισσότερα »
Efficacy of Retromandibular Transparotid Approach for the Management of Extracapsular Subcondylar Mandibular Fractures Using 2-mm Titanium Miniplates: A Prospective Clinical Study
Publication date: August 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 8 Author(s): Narotam Kumar Ghezta, Yogesh Bhardwaj, Pooja Rani, Rangila Ram PurposeThe aim of this study was to evaluate the long-term clinical and radiologic results of the retromandibular transparotid approach to displaced extracapsular subcondylar mandibular fractures.Patients and MethodsA prospective cohort study was conducted over a period of 5 years on patients surgically treated for displaced extracapsular subcondylar mandibular fractures by the retromandibular transparotid appro... περισσότερα »
Discoloration of the mucosa caused by different restorative materials – a spectrophotometric in vitro study
[image: cover.gif?v=1&s=f516d7ea174e5cb36885a956] Abstract Objectives To evaluate the discoloration of the mucosa caused by different ceramic and metal-based materials. Material and Methods On six pig maxillae, trap-door flaps were prepared bilaterally. Different ceramic and metal-based specimens were placed underneath the flap. To simulate increasing mucosal thicknesses (MC), connective tissue grafts (CTGs) were harvested. Spectrophotometric measurements were performed prior to flap elevation (TBL) and for each material under the flap alone (1 mm MC) (TMC1), with a 1-mm CTG (2-mm... περισσότερα »
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
Abstract The spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The ubiquitin-specific protease 39 (USP39) is essential for pre-mRNA splicing, and upregulated USP39 expression is noted in a variety of cancers. However, the role of USP39 in the development and progression of melanoma remains unclear. In the present study, USP39 expression was found to be inc... περισσότερα »
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma
Abstract The spliceosome machinery composed of multimeric protein complexes guides precursor messenger RNAs (mRNAs) (pre-mRNAs) splicing in eukaryotic cells. Spliceosome components have been shown to be downregulated in cancer and could be a promising molecular target for anticancer therapy. The ubiquitin-specific protease 39 (USP39) is essential for pre-mRNA splicing, and upregulated USP39 expression is noted in a variety of cancers. However, the role of USP39 in the development and progression of melanoma remains unclear. In the present study, USP39 expression was found to be inc... περισσότερα »
Growing Your Business with HyperSound
Today’s course will review the new HyperSound Clear 500P technology and how it can grow your practice. My goal is to explain why HyperSound should be included in your current product portfolio and how it can be positioned as a viable recommendation in your clinic. In order to satisfy the needs of new and existing patients, HyperSound ought to be a routine offering, along with hearing aids, assistive devices and aural rehabilitation. from #Audiology via ola Kala on Inoreader http://ift.tt/2aqQYKU via IFTTT
Growing Your Business with HyperSound
Today’s course will review the new HyperSound Clear 500P technology and how it can grow your practice. My goal is to explain why HyperSound should be included in your current product portfolio and how it can be positioned as a viable recommendation in your clinic. In order to satisfy the needs of new and existing patients, HyperSound ought to be a routine offering, along with hearing aids, assistive devices and aural rehabilitation. from #Audiology via ola Kala on Inoreader http://ift.tt/2aqQYKU via IFTTT
Growing Your Business with HyperSound
Today’s course will review the new HyperSound Clear 500P technology and how it can grow your practice. My goal is to explain why HyperSound should be included in your current product portfolio and how it can be positioned as a viable recommendation in your clinic. In order to satisfy the needs of new and existing patients, HyperSound ought to be a routine offering, along with hearing aids, assistive devices and aural rehabilitation. from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aqQYKU via IFTTT
OtoRhinoLaryngology & Medicine,New Articles,July 25th,2016
Effects of insulin on pharmacodynamics of immunosuppressive drugs against mitogen-activated human peripheral-blood mononuclear cells. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 7 δευτερόλεπτα Related Articles *Effects of insulin on pharmacodynamics of immunosuppressive drugs against mitogen-activated human peripheral-blood mononuclear cells.* Immunopharmacol Immunotoxicol. 2016 Jul 21;:1-25 Authors: Shuiling C, Sugiyama K, Inamura M, Tanaka S, Onda K, Huijun Y, Hirano T Abstract CONTEXT: Diabetes mellitus is one of the most common causes o... περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,July 25th,2016
Effects of insulin on pharmacodynamics of immunosuppressive drugs against mitogen-activated human peripheral-blood mononuclear cells. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 7 δευτερόλεπτα Related Articles *Effects of insulin on pharmacodynamics of immunosuppressive drugs against mitogen-activated human peripheral-blood mononuclear cells.* Immunopharmacol Immunotoxicol. 2016 Jul 21;:1-25 Authors: Shuiling C, Sugiyama K, Inamura M, Tanaka S, Onda K, Huijun Y, Hirano T Abstract CONTEXT: Diabetes mellitus is one of the most common causes o... περισσότερα »
Movement-related dynamics of cortical oscillations in Parkinsons disease and essential tremor
Recent electrocorticography data have demonstrated excessive coupling of beta-phase to gamma-amplitude in primary motor cortex and that deep brain stimulation facilitates motor improvement by decreasing baseline phase-amplitude coupling. However, both the dynamic modulation of phase-amplitude coupling during movement and the general cortical neurophysiology of other movement disorders, such as essential tremor, are relatively unexplored. To… Continue reading Movement-related dynamics of cortical oscillations in Parkinsons disease and essential tremor
Corrigendum
http://ift.tt/2anMpkX http://ift.tt/2a59A3N from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2apyqrw via IFTTT
Corrigendum
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2anMpkX via IFTTT
Editorial
http://ift.tt/2anLK39 http://ift.tt/2a59wkr from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2anRBFv via IFTTT
Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife
The ability to detect preclinical Alzheimer’s disease is of great importance, as this stage of the Alzheimer’s continuum is believed to provide a key window for intervention and prevention. As Alzheimer’s disease is characterized by multiple pathological changes, a biomarker panel reflecting co-occurring pathology will likely be most useful for early detection. Towards this end,… Continue reading Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife
Greek medicine: a new look
http://ift.tt/2apsLSr http://ift.tt/2ak7Ss2 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2anRwBM via IFTTT
Cerebello-cortical networks in orthostatic tremor
http://ift.tt/2anLJMD http://ift.tt/2a59uJA from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2apySGu via IFTTT
Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients
[image: alertIcon.gif] Publication date: Available online 22 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Arthur F. Gelb, Jay A. Nadel from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/2a5dbyW
Cerebellar output encodes a corrective motor command
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract The integrity of the cerebellum is critical for accurate eye movements. Disruption of neurons in either the cerebellar oculomotor vermis or its projections to output nucleus of the cerebellum, the caudal fastigial nucleus (cFN), results in significant saccadic dysmetria (Goffart et al., 2004; Ohtsuka et al., 1994; Ritchie, 1976; Buzunov et al. 2013). The relationship between cFN neuron firing rates and saccade kinematic parameters is quite variable across neurons (Hepp et al., 1982; Fuchs et al., 1993), suggesting that a direct encoding of saccade parameters may not occur... περισσότερα »
Regulation of Neurospora Catalase-3 by global heterochromatin formation and its proximal heterochromatin region
[image: S08915849.gif] Publication date: Available online 22 July 2016 *Source:*Free Radical Biology and Medicine Author(s): Yajun Wang, Qing Dong, Zhaolan Ding, Kexin Gai, Xiaoyun Han, Farah Naz Kaleri, Qun He, Ying Wang Catalase-3 (CAT-3) constitutes the main catalase activity in growing hyphae of Neurospora crassa, and its activity increases during exponential growth or is induced under different stress conditions. Although extensive progress has been made to identify catalase regulators, the regulation mechanism of CAT-3 at the chromatin level still remains unclear. Here, we aim... περισσότερα »
Sensors, Vol. 16, Pages 1154: A Network Coverage Information-Based Sensor Registry System for IoT Environments
The Internet of Things (IoT) is expected to provide better services through the interaction of physical objects via the Internet. However, its limitations cause an interoperability problem when the sensed data are exchanged between the sensor nodes in wireless sensor networks (WSNs), which constitute the core infrastructure of the IoT. To address this problem, a Sensor Registry System (SRS) is used. By using a SRS, the information of the heterogeneous sensed data remains pure. If users move along a road, their mobile devices predict their next positions and obtain the sensed data ... περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,July 25th,2016
Effects of insulin on pharmacodynamics of immunosuppressive drugs against mitogen-activated human peripheral-blood mononuclear cells. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 7 δευτερόλεπτα Related Articles *Effects of insulin on pharmacodynamics of immunosuppressive drugs against mitogen-activated human peripheral-blood mononuclear cells.* Immunopharmacol Immunotoxicol. 2016 Jul 21;:1-25 Authors: Shuiling C, Sugiyama K, Inamura M, Tanaka S, Onda K, Huijun Y, Hirano T Abstract CONTEXT: Diabetes mellitus is one of the most common causes ... περισσότερα »
Spatially resolved time-frequency analysis of odour coding in the insect antennal lobe
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract Antennal lobes constitute the first neurophils in the insect brain involved in coding and processing of olfactory information. With their stereotyped functional and anatomical organization, they provide an accessible model with which to investigate information processing of an external stimulus in a neural network *in vivo*. Here, by combining functional calcium imaging with time-frequency analysis, we have been able to monitor the oscillatory components of neural activity upon olfactory stimulation. The aim of the present study is to investigate the presence of stimulus-i... περισσότερα »
Cocaine abstinence induces emotional impairment and brain region-specific upregulation of the oxytocin receptor binding
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract The key problem in treating cocaine addiction is the maintenance of a drug-free state since negative emotional symptoms during abstinence often trigger relapse. The mechanisms underpinning the emotional dysregulation during abstinence are currently not well-understood. There is evidence suggesting a role of the neuropeptide oxytocin in the modulation of drug addiction processes. However, its involvement during long-term abstinence from cocaine use remains unclear. In this study, we aimed to behaviourally characterize a mouse model of long-term cocaine withdrawal and assess... περισσότερα »
Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract Cre-driver mouse lines have been extensively used as genetic tools to target and manipulate genetically defined neuronal populations by expression of Cre recombinase under selected gene promoters. This approach has greatly advanced neuroscience but interpretations are hampered by the fact that most Cre-driver lines have not been thoroughly characterized. Thus, a phenotypic characterization is of major importance to reveal potential aberrant phenotypes prior to implementation and usage to selectively inactivate or induce transgene expression. Here, we present a biochemical... περισσότερα »
(CAG)n loci as genetic modifiers of age-at-onset in patients with Machado-Joseph disease from mainland China
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 2 ώρες
http://ift.tt/2anLSQ0
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου