Study confirms direct link between alcohol and cancer – CNET
CNET You booze, you lose: Study confirms direct link between alcohol and cancer CNET Like a bit of a tipple? You may be increasing your risk of seven types of cancer. According to a new study published today in the journal Addiction, alcohol causes cancer in the oropharynx, larynx, oesophagus, liver, colon, rectum and breast.… Continue reading You booze, you lose: Study confirms direct link between alcohol and cancer – CNET
Analysis of Clinicians ’ Perceptual Cough Evaluation
This study examined the relationships between subjective descriptors and objective airflow measures of cough. We hypothesized that coughs with specific airflow characteristics would share common subjective perceptual descriptions. Thirty clinicians (speech-language pathologists, otolaryngologists, and neurologists) perceptually evaluated ten cough audio samples with specific airflow characteristics determined by peak expiratory flow rate, cough expired volume, cough… Continue reading Analysis of Clinicians ’ Perceptual Cough Evaluation
Production –comprehension asymmetries and the acquisition of evidential morphology
Publication date: August 2016 Source:Journal of Memory and Language, Volume 89 Author(s): Ercenur Ünal, Anna Papafragou Although children typically comprehend the links between specific forms and their meanings before they produce the forms themselves, the opposite pattern also occurs. The nature of these ‘reverse asymmetries’ between production and comprehension remains debated. Here we focus on… Continue reading Production –comprehension asymmetries and the acquisition of evidential morphology
The development of children ’s ability to track and predict turn structure in conversation
Publication date: February 2017 Source:Journal of Memory and Language, Volume 92 Author(s): Marisa Casillas, Michael C. Frank Children begin developing turn-taking skills in infancy but take several years to fluidly integrate their growing knowledge of language into their turn-taking behavior. In two eye-tracking experiments, we measured children’s anticipatory gaze to upcoming responders while controlling linguistic… Continue reading The development of children ’s ability to track and predict turn structure in conversation
Phonetic variation in bilingual speech: A lens for studying the production –comprehension link
Publication date: August 2016 Source:Journal of Memory and Language, Volume 89 Author(s): Melinda Fricke, Judith F. Kroll, Paola E. Dussias We exploit the unique phonetic properties of bilingual speech to ask how processes occurring during planning affect speech articulation, and whether listeners can use the phonetic modulations that occur in anticipation of a codeswitch to… Continue reading Phonetic variation in bilingual speech: A lens for studying the production –comprehension link
Prosody conveys speaker ’s intentions: Acoustic cues for speech act perception
Publication date: June 2016 Source:Journal of Memory and Language, Volume 88 Author(s): Nele Hellbernd, Daniela Sammler Action-theoretic views of language posit that the recognition of others’ intentions is key to successful interpersonal communication. Yet, speakers do not always code their intentions literally, raising the question of which mechanisms enable interlocutors to exchange communicative intents. The… Continue reading Prosody conveys speaker ’s intentions: Acoustic cues for speech act perception
The fate of form in the Humboldtian tradition: The Formungstrieb of Georg von der Gabelentz
Publication date: March 2016 Source:Language & Communication, Volume 47 Author(s): James McElvenny The multifaceted concept of ‘form’ plays a central tole in the linguistic work of Wilhelm von Humboldt (1767–1835), where it is deeply entwined with aesthetic questions. H. Steinthal’s (1823–1899) interpretation of linguistic form, however, made it the servant of psychology. The Formungstrieb (drive… Continue reading The fate of form in the Humboldtian tradition: The Formungstrieb of Georg von der Gabelentz
Analyzing discourse analysis: Teachers ’ views of classroom discourse and student identity
This study yields implications for teacher development as well as furthering understanding about the relationship between language and identity in urban schools. (Source: Linguistics and Education) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2ad6RlB via IFTTT
An instrumental study of oral vowels in the Kedah variety of Acehnese
Publication date: March 2016 Source:Language Sciences, Volume 54 Author(s): Yunisrina Qismullah Yusuf, Stefanie Pillai The variety of Acehnese spoken in Malaysia, in particular the way in which it is pronounced, has thus far received little attention in the literature. One group of Malaysian Acehnese speakers can be found in a village in the northwest of… Continue reading An instrumental study of oral vowels in the Kedah variety of Acehnese
The influence of tense interpretation on discourse coherence —A comparison between Mandarin narrative and report discourse
Publication date: Available online 4 May 2016 Source:Lingua Author(s): Saina Wuyun “Narrative” and “report” are temporal discourse modes that receive different tense interpretations. Adopting Centering Theory as its analytical tool, this article focuses on extended temporal structures in both modes that involve the Mandarin bei-passive construction. By tracking the behavior of an attention-focusing element called… Continue reading The influence of tense interpretation on discourse coherence —A comparison between Mandarin narrative and report discourse
Effectiveness of Superficial Temporal Artery-to-Middle Cerebral Artery Anastomosis in Treating Moyamoya Disease by Reducing Endothelial Progenitor Cells
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 8 δευτερόλεπτα
[image: alertIcon.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Wengao Zhang, Xirui Wang, Zhijing Wang, Jinxing Shang, Haixia Wang, Gangfeng Yin ObjectiveTo explore the effectiveness of superficial temporal artery–to–middle cerebral artery (STA-MCA) anastomosis in treating moyamoya disease (MMD).MethodsA total of 30 patients with MMD (hemorrhagic type, n = 13; ischemic type, n = 17) who had undergone STA-MCA anastomosis were enrolled in this study (anastomosis group). Cerebral blood flow was evaluated before and after surgery using cerebral ... περισσότερα »
Lesion-to-Eloquent Fiber Distance Is a Crucial Risk Factor in Presurgical Evaluation of Arteriovenous Malformations in the Temporo-occipital Junction
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 8 δευτερόλεπτα
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Yuming Jiao, Fuxin Lin, Jun Wu, Hao Li, Lijun Wang, Zhen Jin, Shuo Wang, Yong Cao ObjectiveTemporo-occipital junction arteriovenous malformations (TOJ-AVMs) do not often involve eloquent brain cortex, but rather exist beside functional fiber tracts. The objective of this study was to determine the outcomes after surgical treatment in patients with TOJ-AVMs and to identify risk factors associated with postoperative neurologic deficits.MethodsWe retrospectively studied 41 patients... περισσότερα »
An Approach to Urinary Incontinence for Dermatologists
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 8 δευτερόλεπτα
Incontinence-associated dermatitis (IAD) is a condition often encountered by dermatologists. IAD is an inflammatory skin condition secondary to prolonged urine exposure—it is a dermatologic sequela of urinary incontinence. Incontinence should not be dismissed simply as an age-related disorder; rather, it is due to a number of pathologic conditions that can be either reversible or manageable. It is thus critical to identify and treat the underlying causes of urinary incontinence. Clinical management of this common medical issue restores normality to patients’ lives while also preve... περισσότερα »
Lessons Learned from Delayed Versus Immediate Microsurgical Reconstruction of Complex Maxillectomy and Midfacial Defects
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 8 δευτερόλεπτα
Publication date: Available online 20 July 2016 *Source:*Clinics in Plastic Surgery Author(s): Eric Santamaria, Erika de la Concha Teaser Microsurgical reconstruction of complex midfacial and maxillectomy defects is among the most challenging procedures in plastic surgery, and it often requires composite flaps to improve functional and aesthetic results. Various factors have been identified as having influence in the outcome of microsurgical reconstruction. In this article, the authors present their experience with immediate and delayed reconstruction of complex maxillectomy defect... περισσότερα »
Low-Dose 0.5% 5-Fluorouracil/10% Salicylic Acid Topical Solution in the Treatment of Actinic Keratoses
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 8 δευτερόλεπτα
Background: Actinic keratosis (AK) lesions have the potential to develop into invasive squamous cell carcinomas (SCCs), and approaches to treatment are evolving to try to reduce the burden of SCC. Objective: To present the published clinical research surrounding the use of 0.5% 5-fluorouracil with 10% salicylic acid (low-dose 5-FU/SA) for the treatment of hyperkeratotic AKs. Method: A review of published clinical evidence for low-dose 5-FU/SA for the treatment of AKs. The articles selected represent the peer review publications of clinical studies that primarily investigate the use... περισσότερα »
Lessons Learned from Unfavorable Microsurgical Head and Neck Reconstruction
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 8 δευτερόλεπτα
Publication date: Available online 21 July 2016 *Source:*Clinics in Plastic Surgery Author(s): Yoshihiro Kimata, Hiroshi Matsumoto, Narusi Sugiyama, Satoshi Onoda, Minoru Sakuraba Teaser The risk of surgical site infection (SSI) remains high after major reconstructive surgery of the head and neck. Clinical data regarding SSI in microsurgical tongue reconstruction are described at National Cancer Hospital in Japan, including discussions of unfavorable representative cases, the relationship between SSI and preoperative irradiation at Okayama University Hospital in Japan, and strategi... περισσότερα »
Spatial and temporal patterns in the Pelagibacteraceae across an estuarine gradient
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Marine bacterial communities show strong spatial and seasonal patterns, often characterized by changes at high taxonomic levels. The Pelagibacteraceae are common members of bacterial communities, with well-documented biogeography at the subclade level. To identify patterns within the subclades, the abundance and diversity of Pelagibacteraceae were analyzed over a two-year period at four stations across an estuarine gradient. Pelagibacteraceae was the most abundant bacterial family, averaging 27% of the community, but varying from 1% to 57% in any one sample. Highest abundances wer... περισσότερα »
Endophytic microbial diversity of the halophyte Arthrocnemum macrostachyum across plant compartments
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
In this study, the microbial community structures of the endosphere of the halophyte *Arthrocnemum macrostachyum* were evaluated from two locations in Mallorca, Spain, focusing on three plant compartments (roots, green and red stems) compared to the rhizospheric soil where the plants grew. The physicochemical parameters of the rhizospheric soils differed between locations, and the soils were characterized by different microbial community structures. Accordingly, the endophytic community composition, mainly composed of putatively halophilic organisms, was highly influenced by the r... περισσότερα »
Nitrogen fixation activity in biological soil crusts dominated by cyanobacteria in the Subpolar Urals (European North-East Russia)
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
The nitrogen fixation by biological soil crusts with a dominance of cyanobacteria was studied using the acetylene reduction assay in the territory of the Subpolar Urals (65°11' N, 60°18' E), Russia. The field measurements of nitrogen fixation activity were conducted *in situ* for two different types of soil crusts dominated by *Stigonema* (V1 type) and *Nostoc* with *Scytonema* (V2 type). The nitrogen fixation process had similar dynamics in both crusts but nitrogen fixation rates were different. The crusts of the V2 type showed a significantly higher acetylene reduction activity,... περισσότερα »
Gentamicin-Collagen Sponges for the Prevention of Surgical Site Infections: A Meta-Analysis of Randomized Controlled Trials
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Surgical Infections , Vol. 0, No. 0. http://ift.tt/2afwcOA
Molecular Detection of the Virulent ExoU Genotype of Pseudomonas aeruginosa Isolated from Infected Surgical Incisions
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Surgical Infections , Vol. 0, No. 0. http://ift.tt/2acX1Aj
Response to comments by de Boer & Qiu on “Success of free flap anastomoses performed within the zone of trauma in acute lower limb reconstruction”
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
None. http://ift.tt/29PvZRj
Re: Microvascular free flaps are a safe and suitable training procedure during structured plastic surgery residency: A comparative cohort study with 391 patients
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
We read with interest this paper by Hirche et al., which discussed microvascular training of Plastic Surgery residents. We agree that a residency program should offer work based training opportunities with annual progression towards achieving microsurgical competency. It is excellent that residents are exposed to such valuable free flap surgical experiences, as the microsurgery learning curve is steep. http://ift.tt/29R3i2D
Based on a True Story? the Portrayal of ECT in International Movies and Television Programs.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
[image: S1935861X.gif] Publication date: Available online 20 July 2016 *Source:*Brain Stimulation Author(s): Pascal Sienaert BackgroundMovies and television (TV) programs are an important source of public information about ECT.ObjectiveTo narratively review the portrayal of ECT in international movies and TV programs, from 1948 until present.MethodsSeveral Internet movie databases and a database of phrases appearing in movies and TV programs were searched, supplemented with a Medline-search. No language restrictions were applied.ResultsECT was portrayed in 52 movies (57 scenes), 21 ... περισσότερα »
The Effects of Direct Current Stimulation on Exercise Performance, Pacing and Perception in Temperate and Hot Environments
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 20 July 2016 *Source:*Brain Stimulation Author(s): Martin J Barwood, Jake Butterworth, Jo Corbett, Stuart Goodall, James R. House, Ryan Laws, Alex Nowicky Background.Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulatory technique and has previously been shown to enhance submaximal exercise by reducing rating of perceived exertion (RPE). The present study examined the effects of tDCS on high-intensity self-paced exercise in temperate conditions and fixed followed by maximal exercise in the heat; it w... περισσότερα »
Neurocognitive Effects of Transcranial Direct Current Stimulation in Arithmetic Learning and Performance: a Simultaneous tDCS-fMRI Study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 20 July 2016 *Source:*Brain Stimulation Author(s): Tobias U. Hauser, Bruno Rütsche, Karoline Wurmitzer, Silvia Brem, Christian C. Ruff, Roland H. Grabner BackgroundA small but increasing number of studies suggest that non-invasive brain stimulation by means of transcranial direct current stimulation (tDCS) can modulate arithmetic processes that are essential for higher-order mathematical skills and that are impaired in dyscalculic individuals. However, little is known about the neural mechanisms underlying such stimulation ef... περισσότερα »
Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT–MDM2–p53 signaling axis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Yiping Zhu, Bo Dai, Hailiang Zhang, Guohai Shi, Yijun Shen, Dingwei Ye Long non-coding RNAs (lncRNAs) have been suggested to play important roles in the progression of many cancers such as bladder cancer. However, the detailed mechanism has not been fully understood. We […]
Harnessing 3D models of mammary epithelial morphogenesis: An off the beaten path approach to identify candidate biomarkers of early stage breast cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Stefano Rossetti, Wiam Bshara, Johanna A. Reiners, Francesca Corlazzoli, Austin Miller, Nicoletta Sacchi Regardless of the etiological factor, an aberrant morphology is the common hallmark of ductal carcinoma in situ (DCIS), which is a highly heterogeneous disease. To test if critical core morphogenetic […]
GSK-3 inhibition overcomes chemoresistance in human breast cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Andrey Ugolkov, Irina Gaisina, Jin-San Zhang, Daniel D. Billadeau, Kevin White, Alan Kozikowski, Sarika Jain, Massimo Cristofanilli, Francis Giles, Thomas O’Halloran, Vincent L. Cryns, Andrew P. Mazar Glycogen Synthase Kinase-3β (GSK-3β), a serine/threonine protein kinase, is an emerging therapeutic target in the treatment […]
A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Jing Wu, Ye Ding, Chuan-Huizhi Chen, Zhongmei Zhou, Chunyong Ding, Haiying Chen, Jia Zhou, Ceshi Chen Triple-negative breast cancer (TNBC) remains the leading cause of death among women with breast cancer worldwide. Oridonin is a natural anti-cancer compound that is isolated from the […]
EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through β-catenin/ID2 pathway
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Shi-Jing Mo, Xin Liu, Xiao-Yi Hao, Wei Chen, Kun-Song Zhang, Jian-Peng Cai, Jia-Ming Lai, Li-Jian Liang, Xiao-Yu Yin Eye absent homolog 4 (EYA4) was initially found as key gene in controlling eye development in Drosophila. We recently found that EYA4 was an independent […]
Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Hamid Reza Mirzaei, Hamed Mirzaei, Sang Yun Lee, Jamshid Hadjati, Brian G. Till Excitement is growing for therapies that harness the power of patients’ immune systems to combat their diseases. One approach to immunotherapy involves engineering patients’ own T cells to express a […]
Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Melanie R. Power Coombs, Megan E. Harrison, David W. Hoskin Programmed death ligand 1 (PD-L1) is expressed by many cancer cell types, as well as by activated T cells and antigen-presenting cells. Constitutive and inducible PD-L1 expression contributes to immune evasion by breast […]
Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Asta Försti, Christoph Frank, Bozena Smolkova, Alena Kazimirova, Magdalena Barancokova, Veronika Vymetalkova, Michal Kroupa, Alessio Naccarati, Ludmila Vodickova, Janka Buchancova, Maria Dusinska, Ludovit Musak, Pavel Vodicka, Kari Hemminki Non-specific chromosomal aberrations (CAs) are microscopically detected in about 1% of lymphocytes drawn from healthy […]
Nujiangexathone A, a novel compound from Garcinia nujiangensis, suppresses cervical cancer growth by targeting hnRNPK
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Li Zhang, Jiling Feng, Siyuan Kong, Man Wu, Zhichao Xi, Baojun Zhang, Wenwei Fu, Yuanzhi Lao, Hongsheng Tan, Hongxi Xu Cervical cancer is among the most frequently diagnosed cancers in females worldwide. Nujiangexathone A (NJXA), a novel compound from Garcinia nujiangensis, has been […]
Plk2 promotes tumor growth and inhibits apoptosis by targeting Fbxw7/Cyclin E in colorectal cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα
Publication date: 1 October 2016 Source:Cancer Letters, Volume 380, Issue 2 Author(s): Baochi Ou, Jingkun Zhao, Shaopei Guan, Xiongzhi Wangpu, Congcong Zhu, Yaping Zong, Junjun Ma, Jing Sun, Minhua Zheng, Hao Feng, Aiguo Lu Polo-like kinase 2 (Plk2) and Polo-like kinase 3 (Plk3) have been documented as a tumor suppressor and are lowly expressed in […]
Retention data of bile acids and their oxo derivatives in characterization of pharmacokinetic properties and in silico ADME modeling
Publication date: 20 September 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 92 Author(s): Jovana Trifunović, Vladan Borčić, Saša Vukmirović, Svetlana Goločorbin Kon, Momir Mikov PurposeInformation on ADME properties of examined bile acids and their oxo derivatives are scarce, although the interest for bile acids and their use in nanochemistry and macromolecular chemistry is increasing. The purpose of this research was to evaluate the lipophilicity, a crucial physicochemical parameter for describing ADME properties of selected bile acids and their oxo derivatives... περισσότερα »
Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media
Publication date: 20 September 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 92 Author(s): Vikas Kumar, Sonali S. Bharate, Ram A. Vishwakarma Rohitukine is a medicinally important natural product which has inspired the discovery of two anticancer clinical candidates. Rohitukine is highly hydrophilic in nature which hampers its oral bioavailability. Thus, herein our objective was to improve the drug-like properties of rohitukine via prodrug-strategy. Various ester prodrugs were synthesized and studied for solubility, lipophilicity, chemical stability and enzymatic ... περισσότερα »
The Risk of Glioblastoma with TNF Inhibitors
from Therapeutics via xlomafota13 on Inoreader http://ift.tt/29R3ZsY
Issue Information
from Therapeutics via xlomafota13 on Inoreader http://ift.tt/29R3IX3
Abstracts from the American College of Clinical Pharmacy 2016 Virtual Poster Symposium
from Therapeutics via xlomafota13 on Inoreader http://ift.tt/29Px0ZD
Sleep and sleepiness in environmental intolerances: a population- based study
• Poor sleep is more common in environmental intolerance than in the normal population.• Sleepiness is more common in environmental intolerance than in the normal population.• Persons with environmental intolerance are at larger risk of insomnia.• Environmental intolerance attributed to chemicals and sound are associated to insomnia regardless of distress and certain syndromes. from #SleepMedicine via xlomafota13 on Inoreader http://ift.tt/2afuwVp via IFTTT
Are Vocal Alterations Caused by Smoking in Reinke's Edema in Women Entirely Reversible After Microsurgery and Smoking Cessation?
Reinke's edema is a benign lesion of the vocal folds that affects chronic smokers, especially women. The voice becomes hoarse and virilized, and the treatment is microsurgery. However, even after surgery and smoking cessation, many patients remain with a deep and hoarse voice. from Speech via xlomafota13 on Inoreader http://ift.tt/29Xn1yu
In reply: Comparing face-to-face intubation with different devices
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/29Zc51h
Epidural pressure changes following caudal blockade: a prospective, observational study
Abstract Purpose Recent case reports raise the question as to whether anesthetic agents injected into the epidural space could lead to a 'compartment syndrome' and neurovascular sequelae. Single-shot caudal epidural anesthesia has been established as a safe technique, but changes in pressure in the caudal epidural space have not been described. Our aim was to study pressure changes to provide preliminary information for future studies design. Methods We prospectively measured the pressure changes in the caudal epidural space in 31 pediatric patients. The pressures were measured at... περισσότερα »
Fractional Exhaled Nitric Oxide for the Diagnosis of Childhood Asthma: a Systematic Review and Meta-analysis
Abstract The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthma diagnosis. However, the diagnostic performance of FeNO in children with asthma has not been clearly defined. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of FeNO in the clinical determination of asthma in children. Data... περισσότερα »
Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 40 δευτερόλεπτα
Background. The control of Leishmania braziliensis by individuals with subclinical infection (SC) are unknown. Methods. A cohort of 308 household contacts (HCs) of patients with cutaneous leishmaniasis (CL) was established in 2010 in an endemic area and followed up for 5 years. Whole-blood cultures stimulated with soluble Leishmania antigen and a Leishmania skin test (LST) […]
Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 40 δευτερόλεπτα
Background. West Nile virus (WNV) is an emerging cause of meningitis and encephalitis in the United States. Although severe neuroinvasive disease and death can occur in rare instances, the majority of infected individuals remain asymptomatic or present with a range of clinical manifestations associated with West Nile fever. Methods. To better understand the interindividual variability […]
Hypothyroidism and Prolonged Postoperative Edema After Face-lift Surgery
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 40 δευτερόλεπτα
This review examines whether patients with hypothyroidism are at increased risk for prolonged edema after face-lift surgery. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aeOxLX via IFTTT
The Cost of Facial Deformity—A Health Utility and Valuation Study
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 40 δευτερόλεπτα
This study examines the impact of facial defects on quality of life and willingness to pay, as perceived by society, and highlights the quality of life penalty associated with facial defects and the value society places on their surgical reconstruction. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aeOCzi via IFTTT
Fungal contaminant on BEA
Fungal contaminant seen on Bile Esculin Agar (BEA) after several months at refrigerated temperatures. The fungus was circular at the edges with mounding in the center and blackening of the media indicating esculin hydrolysis. from Infection via ola Kala on Inoreader http://ift.tt/2azEfSx via IFTTT
Table Top Color
Swab taken from the lab table top and incubated on TSA for 48 hrs, left at room temperature for 72 hrs then held at refrigerated temperature for a month. Pictured is a colorful mucoid orange yeast (possible rhodotorula) slowly overtaking several other colonies (yellow is a presumable yeast as we... from Infection via ola Kala on Inoreader http://ift.tt/2acWZbB via IFTTT
Table top mix
Swab taken from the lab table top and incubated on TSA for 48 hrs, left at room temperature for 72 hrs then held at refrigerated temperature for a month. Pictured is a colorful mix of beige mucoid bacteria, orange and yellow mucoid yeast/bacteria, and white grainy fungi (possible actinomyces?). from Infection via ola Kala on Inoreader http://ift.tt/2afwe9f via IFTTT
Fractional Exhaled Nitric Oxide for the Diagnosis of Childhood Asthma: a Systematic Review and Meta-analysis
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Abstract The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthma diagnosis. However, the diagnostic performance of FeNO in children with asthma has not been clearly defined. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of FeNO in the clinical determination of asthma in children. Data... περισσότερα »
Sleep and sleepiness in environmental intolerances: a population- based study
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
• Poor sleep is more common in environmental intolerance than in the normal population.• Sleepiness is more common in environmental intolerance than in the normal population.• Persons with environmental intolerance are at larger risk of insomnia.• Environmental intolerance attributed to chemicals and sound are associated to insomnia regardless of distress and certain syndromes. http://ift.tt/2afuwVp
Are Vocal Alterations Caused by Smoking in Reinke's Edema in Women Entirely Reversible After Microsurgery and Smoking Cessation?
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Reinke’s edema is a benign lesion of the vocal folds that affects chronic smokers, especially women. The voice becomes hoarse and virilized, and the treatment is microsurgery. However, even after surgery and smoking cessation, many patients remain with a deep and hoarse voice. http://ift.tt/29Xn1yu
Facial mimetic, cosmetic, and functional standardized assessment of the facial artery musculomucosal (FAMM) flap
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
To objectively assess donor site morbidity after harvesting the facial artery musculomucosal flap. Use of the FAMM-flap in oral cavity reconstruction remains sporadic. This case series describes our newly developed standardized assessment of this flap in a floor of mouth (FOM) reconstructive setting. http://ift.tt/29XnctF
A Systematic Review of Perioperative Versus Prophylactic Antibiotics for Cochlear Implantation
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Background: Previous Cochrane review of prophylactic antibiotic use in clean and clean-contaminated ear surgery showed no benefit; however, these studies did not address cochlear implant (CI) surgery specifically. Objective: Systematically review effects of perioperative antibiotics on risk of infections and related complications in CI surgery Search methods: PubMed, EMBASE, Medline, CINAHL, and Cochrane library were searched from inception to March 2015. Manual searches of bibliographies were also completed. Selection Criteria: We included all studies that describe perioperative a... περισσότερα »
Depth of Cochlear Implant Array Within the Cochlea and Performance Outcome
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Objective: To evaluate whether the depth of cochlear implant array within the cochlea affects performance outcomes 1 year following cochlear implantation. Methods: A retrospective case review of 120 patients who were implanted with the Advanced Bionics HiFocus 1J. Post-implantation plain-radiographs were retrospectively reviewed, and the depth of insertion was measured in degrees from the round window to the electrode tip. Correlation between the depth of insertion and 1-year post-activation Hearing in Noise Test (HINT) scores was analyzed. Intrascala position was not assessed. Resu... περισσότερα »
The use of conjunctions by children with typical language development
RESUMO Objetivo Verificar o uso das conjunções na fala espontânea de crianças de três anos de idade com desenvolvimento típico de linguagem, residentes do município de Santa Maria - RS. Métodos Participaram da pesquisa 45 crianças, com idades entre 3:0;0 e 3:11;29 (anos:meses;dias), do banco de dados do Centro de Estudos de Linguagem e Fala (CELF). Foi transcrita a fala espontânea de cada sujeito. Em seguida, foram feitas as análises das amostras identificando os tipos de conjunções de cada faixa etária. As amostras foram analisadas estatisticamente, analisando-se o número e o tip... περισσότερα »
Temporal auditory aspects in children with poor school performance and associated factors
RESUMO Objetivo investigar os aspectos temporais auditivos de crianças de 7 a 12 anos de idade com mau desempenho escolar e a associação com aspectos comportamentais, percepção de saúde, perfil escolar e de saúde e fatores sociodemográficos. Métodos trata-se de estudo observacional analítico transversal com 89 crianças de 7 a 12 anos de idade, com mau desempenho escolar das escolas públicas municipais de uma cidade do interior de Minas Gerais, participantes dos Atendimentos Educacionais Especializados. A primeira etapa da pesquisa foi realizada com os pais para coleta de informaçõ... περισσότερα »
School profile and language and cognitive abilities of children and adolescents with autism spectrum disorders
RESUMO Objetivo verificar a correlação entre tempo de permanência semanal na escola, e o desempenho de crianças com Transtorno do Espectro do Autismo em teste de inteligência não verbal e em habilidades comunicativas e de comportamento. Métodos Participaram deste estudo 44 crianças e adolescentes, com idade entre 6 e 12 anos. Todos os participantes estão matriculados em escolas regulares. Resultados Dos 44 participantes, 20 não responderam ao teste de inteligência não verbal; assim, eles foram divididos em dois grupos: - Grupo A: 24 participantes avaliados quanto a desempenho em i... περισσότερα »
Enunciative categories in the description of language functioning of mothers and infants aged 1-4 months
RESUMO Objetivo apresentar categorias que expliquem o funcionamento de linguagem de um bebê com sua mãe a partir do conceito de sistema semiótico benvenisteano e verificar se tais categorias podem ser descritas numericamente. Método Quatro díades foram acompanhadas em três etapas. O primeiro estudo consistiu na análise qualitativa das filmagens transcritas, realizadas em cada uma das etapas. Pretendeu-se identificar os princípios enunciativos atrelados à relação do sistema semiótico corporal do bebê à linguagem materna, a saber, os princípios da interpretância e homologia. Outro e... περισσότερα »
Theory of Mind (ToM) and language: stimulating metalinguistic skills in people with dementia
ABSTRACT Purpose The purpose of this paper was to assess the use of the Metalinguistic Skills Stimulation Program in Theory of Mind (ToM) in people with dementia. Methods An experimental research design was developed. Forty-two subjects, 28 women and 14 men, aged 61 to 87 participated in the study. The three following groups were created: Experimental Group and Control Group - both composed of people with dementia, and Normal Group - consisting of people without dementia or any medical and psychological disorders that keep them from living a normal life. All subjects in the sample... περισσότερα »
Stuttering at school: the effect of a teacher training program on stuttering
RESUMO Objetivo verificar o que docentes de escolas públicas e privadas sabem sobre gagueira, bem como verificar a eficácia do Programa de Formação Docente em Gagueira na ampliação desses conhecimentos. Métodos participaram do estudo 137 docentes da educação infantil. Inicialmente os docentes responderam a um questionário sobre gagueira. Em seguida, 75 docentes participaram do Programa de Formação Docente em Gagueira com duração de quatro horas. Um mês após participação no programa, os docentes responderam novamente ao questionário. Resultados depois da formação, notou-se um aumen... περισσότερα »
Computer-assisted instruction in Speech-Language and Hearing Sciences: impact on motivation for learning about the Orofacial Myofunctional System
RESUMO O objetivo deste estudo foi comparar três métodos de aprendizagem sobre Anatomia e Fisiologia do Sistema Miofuncional Orofacial quanto à motivação para a aprendizagem em Fonoaudiologia. Participaram 36 estudantes do segundo ano de graduação, após assinatura de termo de consentimento livre e esclarecido. Cada estudante foi alocado randomicamente nos grupos: Grupo I (GI) – 12 participantes do Método Interativo 1 (MI1); Grupo II (GII) – 12 participantes do Método Interativo 2 (MI2); Grupo III (GIII) – 12 participantes do Método Tradicional (MT). Os métodos de aprendizagem fora... περισσότερα »
Nasalance values for syllables produced by Brazilian Portuguese speakers
RESUMO Objetivo o objetivo do estudo foi estabelecer valores de nasalância para sílabas produzidas por falantes do Português Brasileiro com diferentes idades e sexo. Métodos Participaram deste estudo 245 falantes do Português Brasileiro (121 do sexo masculino e 124 do sexo feminino), de ambos os sexos, divididos em quatro grupos de idade: 57 crianças, 61 adolescentes, 65 adultos jovens e 62 adultos. Valores de nasalância foram obtidos para um conjunto de 14 sílabas (dez orais e quatro nasais), utilizando o Nasômetro II 6400. Resultados Valores de nasalância mais altos foram encontr... περισσότερα »
Assessment for oral feeding in preterm infants
RESUMO Objetivo avaliar a acurácia do Preterm Oral Feeding Readiness Scale - POFRAS para iniciar a alimentação oral de recém-nascidos pré-termo e verificar a concordância entre este instrumento e o instrumento de avaliação do Nível de Habilidade Oral. Métodos Foram avaliados 82 recém-nascidos pré-termo quanto à prontidão para o início da alimentação oral através do POFRAS e da avaliação do Nível de Habilidade Oral, durante a primeira alimentação oral. A acurácia do POFRAS foi estimada em relação à variável proficiência, por meio da Curva ROC (Receiver Operating Characteristic Curv... περισσότερα »
Influence of speech sample on perceptual rating of hypernasality
RESUMO Objetivo Investigar a influência do tipo de amostra de fala, conversa espontânea ou repetição de sentenças, sobre o índice de concordância intra e interavaliadores obtido na classificação perceptiva da hipernasalidade. Métodos Foram selecionadas e editadas 120 amostras de fala gravadas em áudio (60 contendo trechos de conversa espontânea e 60 contendo repetição de sentenças) de indivíduos com fissura de palato±lábio reparada, de ambos os sexos, com idade entre 6 e 52 anos (média=21±10 anos). Três fonoaudiólogas experientes, utilizando seus critérios internos, classificaram ... περισσότερα »
Children’s language development after cochlear implantation: a literature review
RESUMO Objetivo Levantar na literatura a descrição do desenvolvimento de linguagem de crianças usuárias de implante coclear. Estratégias de pesquisa Buscas na plataforma Pubmed e nas bases de dados Web of Science, Scopus e Science Direct, seguindo etapas de seleção e análise crítica dos periódicos encontrados e escolhidos. Critérios de seleção Selecionados artigos originais que abordavam crianças usuárias de implante coclear, nos quais eram mencionados o desenvolvimento de linguagem após a cirurgia. Excluídos artigos de estudo de caso, dissertações, capítulos de livros, editoriais ... περισσότερα »
Self-assessment and readiness for change in dysphonic patients
RESUMO Objetivo Analisar se existe associação entre a autoavaliação vocal e a prontidão para mudança em pacientes disfônicos. Método Participaram 151 pacientes com queixa vocal e diagnóstico de disfonia, entre 18 e 65 anos de idade, 47 homens e 104 mulheres, atendidos no ambulatório de voz de uma instituição pública. Foram aplicados quatro instrumentos de autoavaliação, incluindo o Questionário de Qualidade de Vida em Voz (QVV), o Índice de Desvantagem Vocal (IDV) e a Escala de Sintomas Vocais (ESV), além da utilização do instrumento URICA-VOZ, para verificação do estágio de pront... περισσότερα »
Relationship between the presence of videolaryngoscopic signs suggestive of laryngopharyngeal reflux and voice disorders in teachers
RESUMO Objetivo Analisar a relação entre a presença de sinais videolaringoscópicos sugestivos de refluxo laringofaríngeo (RLF) e distúrbio de voz (DV) em professoras. Métodos Pesquisa de natureza transversal, com amostra por conveniência que teve, como critérios de inclusão, ter mais de 18 anos, ser professor do sexo feminino, procurar atendimento com queixa de DV e/ou de RLF. Os fatores de exclusão foram: ser fumante e apresentar alterações respiratórias. Todos os sujeitos preencheram os seguintes instrumentos: Condição de Produção Vocal – Professor (CPV-P), inclusive o Índice de... περισσότερα »
Single-stage laparoscopic cholecystectomy and intraoperative endoscopic retrograde cholangiopancreatography: is this strategy feasible in Australia?
Currently in Australasia, concomitant cholecystolithiasis and choledocholithiasis are usually managed with two procedures: laparoscopic cholecystectomy (LC) and pre or postoperative endoscopic retrograde cholangiopancreatography (ERCP). This approach exposes the patient to the risk of complications from the common bile duct stone(s) while awaiting ERCP, the risks of the ERCP itself (particularly pancreatitis) and the need for a second anaesthetic. This article explores the evidence for a newer hybrid approach, single stage LC and intraoperative ERCP (SSLCE) and compares this appr... περισσότερα »
Prognostic significance of the location of metastatic lymph nodes in patients with adenocarcinoma of the oesophagogastric junction
Background Adenocarcinoma of the oesophagogastric junction (AEG) potentially metastasizes to lymph nodes (LNs) in the abdomen and thorax. The aim of this study was to analyse the impact of metastatic LN location on prognosis in patients with AEG. Methods From May 2000 to March 2002, 645 patients with AEG underwent resection in our hospital. There were 525 males and 120 females, aged from 31 to 78 years (median = 60 years). Follow-up was carried out by correspondence every 6 months. N-classification according to the number (0, 1–2, 3–6, >6; N0–3), station (0, 1, 2, 3; S0–3) or fi... περισσότερα »
Factors associated with and consequences of open conversion after laparoscopic distal pancreatectomy: initial experience at a single institution
Background Laparoscopic distal pancreatectomy (LDP) is increasingly adopted today. This study aims to determine factors associated with and consequences of open conversion after LDP. Methods Retrospective review of the first 40 consecutive LDP performed for pancreatic tumors from 2006 to 2015 was performed. Individual surgeon volume was stratified by ≤5 versus >5 cases and institution experience was stratified by two time periods 2006–2010 and 2011–2015. Results Two high-volume surgeons performed 19 cases with an average case volume of ≥2/year whereas 10 low-volume surgeons per... περισσότερα »
Synthetic MR Imaging Sequence in Daily Clinical Practice [LETTERS]
from #Neuroscience via alexandrossfakianakis on Inoreader http://ift.tt/29XrdhF via IFTTT
Reply: [LETTERS]
from #Neuroscience via alexandrossfakianakis on Inoreader http://ift.tt/29XKHa0 via IFTTT
Dual-Energy CT and Spot Sign [LETTERS]
from #Neuroscience via alexandrossfakianakis on Inoreader http://ift.tt/29XriSS via IFTTT
Reply: [LETTERS]
from #Neuroscience via alexandrossfakianakis on Inoreader http://ift.tt/29XLebY via IFTTT
Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T [ADULT BRAIN]
BACKGROUND AND PURPOSE: Schizophrenia is well-known to be associated with hippocampal structural abnormalities. We used 1H-MR spectroscopy to test the hypothesis that these abnormalities are accompanied by NAA deficits, reflecting neuronal dysfunction, in patients compared with healthy controls. MATERIALS AND METHODS: Nineteen patients with schizophrenia (11 men; mean age, 40.6 ± 10.1 years; mean disease duration, 19.5 ± 10.5 years) and 11 matched healthy controls (5 men; mean age, 33.7 ± 10.1 years) underwent MR imaging and multivoxel point-resolved spectroscopy (TE/TR, 35/1400... περισσότερα »
Pediatric Critical Care Resource Use by Children with Medical Complexity
To examine the proportionate use of critical care resources among children of differing medical complexity admitted to pediatric intensive care units (ICUs) in tertiary-care children's hospitals. from Pediatrics via xlomafota13 on Inoreader http://ift.tt/29XdDex
Maternal Prenatal Nutrition and Birth Outcomes on Malnutrition among 7- to 10-Year-Old Children: A 10-Year Follow-Up
To identify postnatal predictors of malnutrition among 7- to 10-year-old children and to assess the long-term effects of antenatal micronutrient supplementation on malnutrition. from Pediatrics via xlomafota13 on Inoreader http://ift.tt/29XdXd5
Reply
Aydin and Winters raise an excellent point regarding the relationship between inflammation and sex hormone-binding globulin (SHBG) as being potentially influential in the increase in total levels of sex hormones after treatment with anti-tumor necrosis factor-α. We did not measure SHBG levels in our participants and are unable to confirm the role that changes in SHBG levels may have played in the increase of total levels of testosterone (Table IV) or estradiol after infliximab treatment. Had we measured SHBG, however, it still may have been difficult to separate the relative contrib... περισσότερα »
The Role of Pediatricians in Caring for the Well-Being of Children Living in New Types of Families
Each person is born into a family characterized by different biological and cultural bonds. Close clan structures developed and persisted in the majority of countries, especially in times and areas of environmental danger, because they can best protect individual family members. On the other hand, clans are based on collectivism and conformism, which are roots of inequality concerning socialization, education, and health care. The long-term success of a clan depends on the number and health of offspring, and thus, the protection and support of children should be at the center of col... περισσότερα »
Salivary Pepsin Lacks Sensitivity as a Diagnostic Tool to Evaluate Extraesophageal Reflux Disease
To determine the sensitivity of salivary pepsin compared with multichannel intraluminal impedance with pH testing (pH-MII), endoscopy, and gastroesophageal reflux disease (GERD) questionnaires. from Pediatrics via xlomafota13 on Inoreader http://ift.tt/29XyVN6
Degradation of Diuron by Electrochemically Activated Persulfate
Abstract An electrochemically activated persulfate (EC/PS) system was proposed for the degradation of herbicide diuron in this study. In the EC/PS system, the ferrous ions (Fe2+) produced from iron electrode can activate persulfate to generate sulfate radical (SO4·-) as well as hydroxyl radical (OH•). The results showed that the degradation of diuron was significantly enhanced in the EC/PS system, compared to electrocoagulation, persulfate, and Fe2+/PS process. Both of SO4·- and OH· contributed to the degradation of diuron in the EC/PS system according to the radical scavenging stud... περισσότερα »
Antibiotic Resistance in Airborne Bacteria Near Conventional and Organic Beef Cattle Farms in California, USA
Abstract Levels of antibiotic resistance genes (ARGs) and the fractions of antibiotic resistant bacteria (ARB) among culturable heterotrophic bacteria were compared in outdoor air near conventional (*n* = 3) and organic (*n* = 3) cattle rearing facilities. DNA extracts from filters taken from 18 locations were analyzed by quantitative polymerase chain reaction (qPCR) for five ARGs. At the reference (non-agricultural) site, all genes were below detection. ARGs *sul*1, *bla* SHV, *erm*(B), and *bla* TEM were more frequently detected and at higher levels (up to 870 copies m−3 for *bla*... περισσότερα »
Plural large floating thrombi in the ascending aorta
Abstract Floating thrombi in the ascending aorta are a very rare finding in non-aneurysmal, mildly atherosclerotic or normal aortas. We report a case of floating thrombi in a 66-year-old man who was admitted to the hospital with acute chest pain and dyspnea. Enhanced computed tomography showed two large floating thrombi in the ascending aorta, type B aortic dissection, deep venous thrombosis, and pulmonary embolism. A temporary inferior vena cava filter was inserted and the subject underwent an emergency surgical intervention to remove both masses. His postoperative course was unev... περισσότερα »
Multicenter prospective study of sublobar resection for c-stage I non-small cell lung cancer patients unable to undergo lobectomy (KLSG-0801): complete republication
AbstractBackground Local therapy for stage I non-small cell lung cancer (NSCLC) is divided into surgical and radiation treatment, and given to patients unable to tolerate a lobectomy. A prospective phase II study of cases that received stereotactic body radio therapy (SBRT) (JCOG0403) revealed an overall 3-year survival rate (3-YSR) of 76.0 %, 3-year relapse free survival rate (3-YRFS) of 69.0 %, and rate of morbidity of grade 3 or greater of 9 %. However, few prospective multicenter studies have reported regarding surgery for high-risk stage I NSCLC patients. Methods We investigat... περισσότερα »
Multidisciplinary approach to treatment of radiation-induced chest wall sarcoma
Abstract Radiation-induced sarcoma (RIS) is a rare complication following therapeutic external irradiation for lung cancer patients. Patients with RIS may develop recurrence or metastasis of the previous disease and also at high risk for early chest wall complications following operation, which requires close follow-up and multidisciplinary approach. We present a challenging case of RIS with a multidisciplinary teamwork in the decision-making and successful management. from Respiratory via xlomafota13 on Inoreader http://ift.tt/2acIbK3
Coronary artery bypass grafting in a patient with hemophilia B: continuous recombinant factor IX infusion as per the Japanese guidelines for replacement therapy
Abstract We herein report our experience of successfully managing the hemostatic system by controlling serum factor IX levels throughout the perioperative period in a patient with hemophilia B. Coronary artery bypass grafting with cardiopulmonary bypass was planned for a 52-year-old man with moderate severity of hemophilia B. During surgery, recombinant factor IX (rFIX; BeneFIX® Pfizer Japan inc., Tokyo, Japan) was administered by bolus infusion followed by continuous infusion as per the guidelines of the Japanese Society on Thrombosis and Hemostasis. The operative course was uneve... περισσότερα »
Successful resection of recurrent mediastinal liposarcoma using preoperative evaluation of organ invasion by four-dimensional computed tomography
Abstract We report the case of a 64-year-old woman with recurrent mediastinal dedifferentiated liposarcoma. She had undergone surgical resection twice. Subsequently, on regular follow-up visits, chest computed tomography demonstrated a third local recurrence of the tumor with invasion into adjacent intrathoracic organs. Adhesion of the heart to the anterior chest wall through a pericardial defect that had been inadvertently created at the second operation was suspected. We decided to use a thoracoabdominal approach with four-dimensional computed tomography (4DCT) for preoperative g... περισσότερα »
Fractional Exhaled Nitric Oxide for the Diagnosis of Childhood Asthma: a Systematic Review and Meta-analysis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthma diagnosis. However, the diagnostic performance of FeNO in children with […]
Sleep and sleepiness in environmental intolerances: a population- based study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
• Poor sleep is more common in environmental intolerance than in the normal population.• Sleepiness is more common in environmental intolerance than in the normal population.• Persons with environmental intolerance are at larger risk of insomnia.• Environmental intolerance attributed to chemicals and sound are associated to insomnia regardless of distress and certain syndromes. http://ift.tt/2afuwVp http://ift.tt/2a4DbYA
Validation of a Hemodynamic Model for the Study of the Cerebral Venous Outflow System Using MR Imaging and Echo-Color Doppler Data [EXTRACRANIAL VASCULAR]
BACKGROUND AND PURPOSE: A comprehensive parameter model was developed to investigate correlations between cerebral hemodynamics and alterations in the extracranial venous circulation due to posture changes and/or extracranial venous obstruction (stenosis). The purpose of this work was to validate the simulation results by using MR imaging and echo-color Doppler experimental blood flow data in humans. MATERIALS AND METHODS: To validate the model outcomes, we used supine average arterial and venous extracerebral blood flow, obtained by using phase-contrast MR imaging from 49 indi... περισσότερα »
CT and MR Imaging in the Diagnosis of Scleritis [HEAD & NECK]
SUMMARY: Scleritis is a rare, underdiagnosed vision-threatening condition that can occur isolated or in association with other orbital abnormalities. The etiology of scleritis is mainly inflammatory noninfectious, either idiopathic or in the context of systemic disease. Ultrasonography remains the criterion standard in diagnostic imaging of this condition but might prove insufficient, and studies on the diagnostic value of CT and MR imaging are lacking. We retrospectively analyzed 11 cases of scleritis in which CT and/or MR imaging were performed during the active phase of disea... περισσότερα »
A Semiautomatic Method for Multiple Sclerosis Lesion Segmentation on Dual-Echo MR Imaging: Application in a Multicenter Context [ADULT BRAIN]
BACKGROUND AND PURPOSE: The automatic segmentation of MS lesions could reduce time required for image processing together with inter- and intraoperator variability for research and clinical trials. A multicenter validation of a proposed semiautomatic method for hyperintense MS lesion segmentation on dual-echo MR imaging is presented. MATERIALS AND METHODS: The classification technique used is based on a region-growing approach starting from manual lesion identification by an expert observer with a final segmentation-refinement step. The method was validated in a cohort of 52 pa... περισσότερα »
Sleep and sleepiness in environmental intolerances: a population- based study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
• Poor sleep is more common in environmental intolerance than in the normal population.• Sleepiness is more common in environmental intolerance than in the normal population.• Persons with environmental intolerance are at larger risk of insomnia.• Environmental intolerance attributed to chemicals and sound are associated to insomnia regardless of distress and certain syndromes. from #SleepMedicine […]
Are Vocal Alterations Caused by Smoking in Reinke’s Edema in Women Entirely Reversible After Microsurgery and Smoking Cessation?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Reinke’s edema is a benign lesion of the vocal folds that affects chronic smokers, especially women. The voice becomes hoarse and virilized, and the treatment is microsurgery. However, even after surgery and smoking cessation, many patients remain with a deep and hoarse voice. http://ift.tt/29Xn1yu http://ift.tt/2a3z3J4
Facial mimetic, cosmetic, and functional standardized assessment of the facial artery musculomucosal (FAMM) flap
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
To objectively assess donor site morbidity after harvesting the facial artery musculomucosal flap. Use of the FAMM-flap in oral cavity reconstruction remains sporadic. This case series describes our newly developed standardized assessment of this flap in a floor of mouth (FOM) reconstructive setting. http://ift.tt/29XnctF http://ift.tt/2a0CyfM
Sleep and sleepiness in environmental intolerances: a population- based study
• Poor sleep is more common in environmental intolerance than in the normal population.• Sleepiness is more common in environmental intolerance than in the normal population.• Persons with environmental intolerance are at larger risk of insomnia.• Environmental intolerance attributed to chemicals and sound are associated to insomnia regardless of distress and certain syndromes. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/2afuwVp via IFTTT
Editorial Protocol disparities and research governance
To improve health, research should be reported fully and transparently. If this is not done, it is important to understand why, as discussed today in Correspondence about a trial of neurodevelopmental outcomes after anaesthesia in infancy. Article authors, Andrew Davidson and colleagues, respond to COMPare by explaining that the discrepancies in their reporting were minor… Continue reading Editorial Protocol disparities and research governance
Response to comments by de Boer & Qiu on “Success of free flap anastomoses performed within the zone of trauma in acute lower limb reconstruction”
None. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29PvZRj via IFTTT
Obituary Suzanne Corkin
Neuropsychologist who studied human memory. Born in Hartford, CT, USA, on May 18, 1937, she died of liver cancer in Danvers, MA, USA, on May 24, 2016, aged 79 years. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2afqVGP via IFTTT
Microvascular free flaps are a safe and suitable training procedure during structured plastic surgery residency: A comparative cohort study with 391 patients
We read with interest this paper by Hirche et al., which discussed microvascular training of Plastic Surgery residents. We agree that a residency program should offer work based training opportunities with annual progression towards achieving microsurgical competency. It is excellent that residents are exposed to such valuable free flap surgical experiences, as the microsurgery learning… Continue reading Microvascular free flaps are a safe and suitable training procedure during structured plastic surgery residency: A comparative cohort study with 391 patients
Correspondence Zika virus epidemic: Africa should not be neglected
The Zika virus was first isolated in Uganda in 1947.1 Despite the recent severe outbreak of Zika virus in Cape Verde, with 7557 suspected cases between Oct 21, 2015, and May 8, 2016, very little attention has been paid to the African continent for participation in Zika virus outbreak preparedness programmes. from #Medicine-Sfakianakis via simeraentaxei… Continue reading Correspondence Zika virus epidemic: Africa should not be neglected
Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediat ed by breast milk TSLP or TGF-β
Abstract Background The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence of atopic dermatitis (AD) in infancy. The mechanisms behind this effect are incompletely understood and breast milk cytokines have been postulated as possible mediating factors. In… Continue reading Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediat ed by breast milk TSLP or TGF-β
Correspondence Could clinical symptoms be a predictor of complications in Zika virus infection?
Compelling evidence of the relation between Zika virus and microcephaly has been emerging in the scientific literature, although the risk in infected pregnant women remains largely unknown. Using retrospective data from routine ultrasonography and clinical examination at birth, Simon Cauchemez and colleagues (May 21, p2125)1 estimated the risk of microcephaly in newborn babies of infected… Continue reading Correspondence Could clinical symptoms be a predictor of complications in Zika virus infection?
Postoperative persistent chronic pain: what do we know about prevention, risk factors, and treatment
Publication date: Available online 20 July 2016 Source:Brazilian Journal of Anesthesiology (English Edition) Author(s): Durval Campos Kraychete, Rioko Kimiko Sakata, Leticia de Oliveira Carvalho Lannes, Igor Dórea Bandeira, Eduardo Jun Sadatsune Background and objectivesPostoperative persistent chronic pain (POCP) is a serious health problem, disabling, undermining the quality of life of affected patients. Although more studies… Continue reading Postoperative persistent chronic pain: what do we know about prevention, risk factors, and treatment
Department of Error Department of Error
Brown SR, Tiernan JP, Watson AJM, et al. Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial. Lancet 2016; 388: 356–64—In this Article, the results for mean EQ-5D utility score should have been: “For RBL the mean at day 1 was… Continue reading Department of Error Department of Error
Advanced practice providers improve efficiency and decrease costs in outpatient oral-maxillofacial surgery
To determine the effects on time, cost and complication rates of integrating advanced practice providers (APP) into the procedural components of an outpatient oral-maxillofacial surgery practice. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2agRSqD via IFTTT
Post-traumatic osteomyelitis: an unresolved conundrum in orthopedic trauma surgery
from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29QYfPF
Are Vocal Alterations Caused by Smoking in Reinke's Edema in Women Entirely Reversible After Microsurgery and Smoking Cessation?
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 ώρες
Reinke's edema is a benign lesion of the vocal folds that affects chronic smokers, especially women. The voice becomes hoarse and virilized, and the treatment is microsurgery. However, even after surgery and smoking cessation, many patients remain with a deep and hoarse voice. http://ift.tt/29Xn1yu
Facial mimetic, cosmetic, and functional standardized assessment of the facial artery musculomucosal (FAMM) flap
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 ώρες
To objectively assess donor site morbidity after harvesting the facial artery musculomucosal flap. Use of the FAMM-flap in oral cavity reconstruction remains sporadic. This case series describes our newly developed standardized assessment of this flap in a floor of mouth (FOM) reconstructive setting. http://ift.tt/29XnctF
A Systematic Review of Perioperative Versus Prophylactic Antibiotics for Cochlear Implantation
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 ώρες
Background: Previous Cochrane review of prophylactic antibiotic use in clean and clean-contaminated ear surgery showed no benefit; however, these studies did not address cochlear implant (CI) surgery specifically. Objective: Systematically review effects of perioperative antibiotics on risk of infections and related complications in CI surgery Search methods: PubMed, EMBASE, Medline, CINAHL, and Cochrane library were searched from inception to March 2015. Manual searches of bibliographies were also completed. Selection Criteria: We included all studies that describe periopera... περισσότερα »
Depth of Cochlear Implant Array Within the Cochlea and Performance Outcome
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 ώρες
Objective: To evaluate whether the depth of cochlear implant array within the cochlea affects performance outcomes 1 year following cochlear implantation. Methods: A retrospective case review of 120 patients who were implanted with the Advanced Bionics HiFocus 1J. Post-implantation plain-radiographs were retrospectively reviewed, and the depth of insertion was measured in degrees from the round window to the electrode tip. Correlation between the depth of insertion and 1-year post-activation Hearing in Noise Test (HINT) scores was analyzed. Intrascala position was not assessed. ... περισσότερα »
Cutaneous Myiasis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 ώρες
Abstract Myiasis is defined as the infestation of live vertebrates, either humans or animals, with dipterous larvae. Many organs can be infested by these larvae with cutaneous myiasis being the most common form. Cutaneous myiasis can be divided into three categories: localized furuncular myiasis, migratory myiaisis and wound myiasis, which occurs when fly larvae infest the open wounds of the host. Human myiasis has worldwide distribution, with more species and a heavier burden in tropical and subtropical countries. In recent years with increased travel to the tropics, myiasis has b... περισσότερα »
Cryptococcal Disease in HIV-Infected Children
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 ώρες
Abstract *Cryptococcus neoformans* is an encapsulated fungal pathogen that is remarkable for its tendency to cause meningoencephalitis, especially in patients with AIDS. While disease is less common in children than adults, it remains an important cause of morbidity and mortality among HIV-infected children without access to anti-retroviral therapy. This review highlights recent insights into both the biology and treatment of cryptococcosis with a special emphasis on the pediatric literature. http://ift.tt/2a0qwDe
Role of tumor-associated macrophages in human malignancies: friend or foe?
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 ώρες
Tumor-associated macrophages (TAMs) play a pivotal role in tumor growth in human malignancies. Published studies have analyzed the relationship between TAM infiltration and the prognosis of patients for many human tumors. Most studies reported a positive correlation between TAM density and a poor prognosis. Studies focusing on macrophage phenotypes emphasized the protumor role of M2 anti-inflammatory macrophages in many types of human tumors. However, TAMs influence tumor progression in various ways that depend on differences in tumor sites, histology, and microenvironments. In t... περισσότερα »
Sleep and sleepiness in environmental intolerances: a population- based study
• Poor sleep is more common in environmental intolerance than in the normal population.• Sleepiness is more common in environmental intolerance than in the normal population.• Persons with environmental intolerance are at larger risk of insomnia.• Environmental intolerance attributed to chemicals and sound are associated to insomnia regardless of distress and certain syndromes. from #SleepMedicine via xlomafota13 on Inoreader http://ift.tt/2afuwVp via IFTTT
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