Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τρίτη 2 Αυγούστου 2016

OtoRhinoLaryngology & Medicine,New Articles,August 2nd,2016,afternoon


OtoRhinoLaryngology - Alexandros G. Sfakianakis
Advanced titration to treat a floppy epiglottis in selective upper airway stimulation
Advanced titration to treat a floppy epiglottis in selective upper airway stimulation: The following report presents a case of a patient with high residual apnea-hypopnea index at 6 months following implantation of an upper airway stimulation device who improved significantly after advanced titration...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
A novel approach to cricoarytenoid joint injections
An anatomic study: ObjectivesTo demonstrate a novel approach to cricoarytenoid joint (CAJ) injections.Study DesignAnatomic feasibility study.MethodsFive human cadaveric larynges providing 10 CAJ s were used to obtain trajectory measurements of a 27-gauge 1½-inch needle placed between the CAJ capsule...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Malpractice litigation relating to melanoma involves numerous physicians, including dermatologists, pathologists, and otolaryngologists. Alleged misdiagnosis of a pigmented lesion was the most common cause of litigation and involved physicians from numerous specialties. Patients who were misdiagnosed had a significantly higher likelihood of having active disease at the time of litigation. Ultimately improved methods of detecting concerning pigmented lesions need to be developed. Factors such as death and poor cosmetic outcome did not significantly impact litigation outcome.
A critical analysis of melanoma malpractice litigation: Should we biopsy everything?: Objectives/HypothesisThe aim of this study was to evaluate factors raised in malpractice litigation related to the diagnosis and management of melanoma and to further assess issues impacting outcome.Study DesignRetrospective...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Blunt cerebrovascular injury following craniomaxillofacial fractures
A systematic review: ObjectivesBlunt cerebrovascular injury (BCVI) is a known sequela of high-energy craniomaxillofacial (CMF) trauma and can result in stroke or death. The objective of this systematic review is to 1) identify CMF trauma patients who may benefit from BCVI screening and 2) describe the...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Role of 18F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma
Role of 18F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma: ObjectivesThe purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB)...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Of patients undergoing thyroidectomy, Graves disease is the only indication in which patients are at increased risk of postoperative hematoma formation.
Is there a group of patients at greater risk for hematoma following thyroidectomy? A systematic review and meta-analysis: ObjectiveThe purpose of this study was to perform a systematic review and meta-analysis to determine whether a difference exists in hematoma rates following thyroidectomy for any...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Impact of mandibular invasion on prognosis in oral squamous cell carcinoma four centimeters or less in size
Impact of mandibular invasion on prognosis in oral squamous cell carcinoma four centimeters or less in size: Objectives/HypothesisPrevious studies have reported variable results for the impact of bone invasion on survival in oral cancer. It is unclear whether bone invasion in small (≤4 cm) squamous cell...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Angiolymphoid Hyperplasia With Eosinophilia Within a Vascular Malformation
Case Report and Review of the Literature: Objectives:Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign microvascular proliferation tumor. The etiology of ALHE is unknown, though some hypothesize it occurs in reaction to focal trauma. This study presents a case of AHLE within a vascular...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Dual pH, Full Column Impedance Testing
Nissen Fundoplication for Laryngopharyngeal Reflux After Patient Selection Using Dual pH, Full Column Impedance Testing: A Pilot Study: Objectives:Prior studies demonstrate inconsistent diagnostic strategies for laryngopharyngeal reflux disease (LPR) patients who are offered laparoscopic Nissen fundoplication...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Nissen Fundoplication for Laryngopharyngeal Reflux
 After Patient Selection Using Dual pH, Full Column Impedance Testing: A Pilot Study: Objectives:Prior studies demonstrate inconsistent diagnostic strategies for laryngopharyngeal reflux disease (LPR) patients who are offered laparoscopic Nissen fundoplication (Nissen). Superior symptom resolution outcomes...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Middle Cranial Fossa Dehiscence
 as an Incidental Finding on CT: Objectives:This retrospective chart review demonstrates that the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans increases with age.Methods:High-resolution temporal bone CT scans, which had been obtained for any otologic complaint,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Nasal polyps found occasionally are often part of a chronic entity but do not necessarily evolve into a more serious condition over time. Treatment should therefore be based on the patients’ subjective problems.
What Happens With Untreated Nasal Polyps Over Time? A 13-Year Prospective Study: Objectives:Nasal polyps are often seen in ENT practice, but little is known about the pathogenesis and the natural development. Our objective was to follow individuals with untreated nasal polyps prospectively, in terms...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Esophageal Swallowing Timing Measures in Healthy Adults During Videofluoroscopy
Esophageal Swallowing Timing Measures in Healthy Adults During Videofluoroscopy: Objectives:Establishing the range of normal esophageal bolus transit times (ETT) is valuable when distinguishing pathology from normal variance, especially in elderly patients, and has not been documented for paste or pill....
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Safety of Monopolar Electrocautery in Patients With Cochlear Implants
Safety of Monopolar Electrocautery in Patients With Cochlear Implants: Objective:The outcomes of 2 patients with cochlear implants (CIs) who underwent adenotonsillectomy (AT) with inadvertent use of monopolar cautery are presented. The safety data regarding monopolar cautery use in CI recipients is also...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The 6p25 deletion syndrome is one of the many syndromes with both hearing impairment as well as vision impairment.
Phenotype of a Belgian Family With 6p25 Deletion Syndrome: Background:The 6p25 deletion syndrome is one of the many syndromes with both hearing impairment as well as vision impairment. However, the audiometric characteristics and radiological findings of patients with 6p25 deletions are only scarcely...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Lateral Cricoarytenoid Release: Development of a Novel Surgical Treatment Option for Adductor Spasmodic Dysphonia in a Canine Laryngeal Model
Lateral Cricoarytenoid Release: Development of a Novel Surgical Treatment Option for Adductor Spasmodic Dysphonia in a Canine Laryngeal Model: Objective:To investigate the efficacy of a novel adductor muscle-releasing technique designed to decrease the force of vocal fold adduction, as a potential surgical...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Reduction malarplasty by bidirectional wedge ostectomy or two percutaneous osteotomies
Article in Press according to zygoma protrusion typeWooyeol Baek, M.D., Taeyong Woo, M.D., Young Seok Kim, M.D., In Sik Yun, M.D., Ph.D., Jimyung Kim, M.D., Se Woon Choi, M.D., Dr. Tai Suk Roh, M.D., Ph.D.Press enter key for correspondence informationPress enter key to Email the author, Dae hyun Lew,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Prevention of Bisphosphonate-Related Osteonecrosis of the Jaws
Article in Press in Patients with Prostate Cancer Treated with Zoledronic acid – a prospective study over 6 yearsPriv.-Doz. Dr. Dr. Thomas Mücke, PhD, MD, DDSPress enter key for correspondence informationPress enter key to Email the author, Herbert Deppe, PhD, DDS, Jana Hein, MD, Klaus-Dietrich Wolff,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
T-cell cross-reactivity in allergen protein families
Article in PressReplyLuise Westernberg, PhD, Veronique Schulten, PhD, Alessandro Sette, PhD, Bjoern Peters, PhDPress enter key to Email the authorLa Jolla Institute for Allergy and Immunology, La Jolla, CalifDOI: http://dx.doi.org/10.1016/j.jaci.2016.04.054Article InfoAbstractFull TextReferencesTo the...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
T-cell receptor–mediated cross-reactivity to different allergens
Article in PressT-cell receptor–mediated cross-reactivity to different allergens is driven by recognition of homologous, phylogenetically conserved epitopesSamuele E. Burastero, MDPress enter key to Email the authorDepartment of Biotechnology, San Raffaele Scientific Institute, Milan, ItalyDOI: http://dx.doi.org/10.1016/j.jaci.2016.04.055Article...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation
MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation: To date, few inhibitory signals for ILC2s have been described. Our study demonstrates that miR-155 is required for allergen-induced ILC2 expansion and IL-33...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pitch-raising Surgery : Laryngeal web formation seems risky for decreasing voice quality
Article in PressThe Effectiveness of Pitch-raising Surgery in Male-to-Female Transsexuals: A Systematic ReviewSilke Van DammePress enter key for correspondence informationPress enter key to Email the author, Marjan Cosyns, Sofie Deman, Zoë Van den Eede, John Van BorselWasstraat 96, B-9000 Ghent, BelgiumDOI: http://dx.doi.org/10.1016/j.jvoice.2016.04.002Article...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Singing power ratio (SPR)—as an objective measure to quantify the resonant voice quality
Article in PressObjective Identification of Prepubertal Female Singers and Non-singers by Singing Power Ratio Using MatlabM. UshaPress enter key for correspondence informationPress enter key to Email the author, Y.V. Geetha, Y.S. DarshanDOI: http://dx.doi.org/10.1016/j.jvoice.2016.06.016Article InfoAbstractFull...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Astaxanthin can protect the vocal fold from injury and inflammation caused by vocal loading possibly through the regulation of oxidative stress
Article in PressProtective Effect of Astaxanthin on Vocal Fold Injury and Inflammation Due to Vocal Loading: A Clinical TrialMami Kaneko, Yo Kishimoto, Ryo Suzuki, Yoshitaka Kawai, Ichiro Tateya, Shigeru HiranoPress enter key for correspondence informationPress enter key to Email the authorDOI: http://dx.doi.org/10.1016/j.jvoice.2016.06.017Article...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Voice Rest After Vocal Fold Surgery: 3 days of voice rest followed by voice therapy may lead to better wound healing of the vocal fold compared to 7 days of voice rest
Article in PressOptimal Duration for Voice Rest After Vocal Fold Surgery: Randomized Controlled Clinical StudyMami Kaneko, Osamu Shiromoto, Masako Fujiu-Kurachi, Yo Kishimoto, Ichiro Tateya, Shigeru HiranoPress enter key for correspondence informationPress enter key to Email the authorDOI: http://dx.doi.org/10.1016/j.jvoice.2016.02.009Article...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
In-Office Secondary Tracheoesophageal Puncture with Immediate Prosthesis Placement
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OtoRhinoLaryngology by Alexandros G.Sfakianakis
Retromaxillary Pneumatization of Posterior Ethmoid Air Cells: Novel Description and Surgical Implications
Objective Retromaxillary pneumatization of posterior ethmoid (PE) air cells is an area that is yet to have appropriate description in rhinologic literature. Study Design Case series with chart review. Setting Tertiary care hospital. Subjects and Methods First, 524 sides in 262 paranasal sinus...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Successful Use of Radiotherapy for Pterygopalatine Fossa Amyloidosis
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OtoRhinoLaryngology by Alexandros G.Sfakianakis
Cephalic Vein Transposition in the Vessel-Depleted Neck
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OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Vocal Tract Discomfort (VTD) Scale
Transcultural Adaptation and Validation of the German Version of the Vocal Tract Discomfort Scaleby Julia Lukaschyk, Meike Brockmann-Bauser, Ulla Beushausen via Journal of VoiceCurrently, there is no standardized German questionnaire to assess vocal tract discomfort in voice patients. The aim of this...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Unsuccessful or poorly conducted endotracheal intubation can be life-threatening : When in doubt, extubate the patient
When in doubt, extubate the patient: By Bradley DeanFollowing the 2013 death of Drew Hughes, a lawsuit was filed alleging the hospital and/or its employees, "failed to keep Drew Hughes properly sedated and restrained; failed to properly re-intubate Andrew Davis Hughes during the transport; failed to...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Efficacy of Intra-Alveolar 0.2% Chlorhexidine Gel on Alveolar Osteitis: A Meta-Analysis
The Efficacy of Intra-Alveolar 0.2% Chlorhexidine Gel on Alveolar Osteitis: A Meta-Analysis: AbstractObjectivesThe objective of this meta-analysis was to assess the effect of 0.2% chlorhexidine gel in preventing alveolar osteitis following mandibular third molar extraction(s).MethodsPubMed, Cochrane...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Non-invasive diagnostic tools in the field of head and neck oncology : A liquid biopsy for head and neck cancers
The development of a liquid biopsy for head and neck cancersvia ScienceDirect Publication: Oral OncologyPublication date: October 2016Source:Oral Oncology, Volume 61Author(s): Henri Schmidt, Arutha Kulasinghe, Liz Kenny, Chamindie PunyadeeraDeveloping non-invasive diagnostic tools in the field of head...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Orbital Metastasis of Breast Cancer Mimicking Invasive Fungal Rhinosinusitis
Orbital Metastasis of Breast Cancer Mimicking Invasive Fungal Rhinosinusitis: Introduction. A range of traumatic, vascular, inflammatory, infectious, and neoplastic processes can affect the orbit and its structures. In the area of otolaryngology, the rhino-orbital-cerebral involvement of invasive fungal...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Rare compound heterozygosity involving dominant and recessive mutations of GJB2 gene in an assortative mating hearing impaired Indian family
Rare compound heterozygosity involving dominant and recessive mutations of GJB2 gene in an assortative mating hearing impaired Indian family: AbstractConnexin 26 (Cx-26), a gap junction protein coded by GJB2 gene, plays a very important role in recycling of potassium ions, one of the vital steps in the...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
A parametric vocal fold model based on magnetic resonance imaging
A parametric vocal fold model based on magnetic resonance imaging: This paper introduces a parametric three-dimensional body-cover vocal fold model based on magnetic resonance imaging (MRI) of the human larynx. Major geometric features that are observed in the MRI ...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
On the completeness and the linear dependence of the Cartesian multipole series in representing the solution to the Helmholtz equation
On the completeness and the linear dependence of the Cartesian multipole series in representing the solution to the Helmholtz equation: The (Cartesian) multipole series, i.e., the series comprising monopole, dipoles, quadrupoles, etc., can be used, as an alternative to the spherical or cylindrical wave...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes
Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes: ObjectiveTo investigate the efficacy, safety, and microbiology of a thermosensitive otic suspension of ciprofloxacin (OTO-201) in children with bilateral middle ear effusion undergoing tympanostomy tube...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Effects of Continuous Positive Airway Pressure on Middle Ear Pressure and Acoustic Stapedial Reflex
Effects of Continuous Positive Airway Pressure on Middle Ear Pressure and Acoustic Stapedial Reflex: ObjectiveThis study investigated the effects of continuous positive airway pressure (CPAP) on middle ear pressure and acoustic stapedial reflex and the correlation between CPAP and middle ear pressure.Study...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Acoustic effects of the reconstructed lateral epitympanic wall in a temporal bone and clinical study
Acoustic effects of the reconstructed lateral epitympanic wall in a temporal bone and clinical study: ObjectiveAcoustic evaluation of reconstruction of the lateral epitympanic wall with bone or cartilage in a temporal bone study, and evaluation of audiometric data of patients who underwent cholesteatoma...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Frequent tuberculosis in patients with Takayasu arteritis (TA)
Comparison of clinical characteristics in patients with Takayasu arteritis with and without concomitant tuberculosis: AbstractBecause of frequent tuberculosis in patients with Takayasu arteritis (TA), a possible relationship between TA and tuberculosis has been proposed. However, there are no studies...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Patch testing for investigating non-immediate cutaneous adverse drug reactions to antibiotics
Patch testing – a valuable tool for investigating non-immediate cutaneous adverse drug reactions to antibiotics: AbstractBackgroundAntibiotics are among the most frequent causes of cutaneous adverse drug reactions (CADR); patch testing may be an important tool in their evaluation and management. We assessed...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Different Radiation Dose With Concurrent Chemotherapy for Thoracic Esophageal Carcinoma
Different Radiation Dose With Concurrent Chemotherapy for Thoracic Esophageal Carcinoma: Condition:   Esophageal CancerInterventions:   Radiation: High-dose;   Radiation: Standard-doseSponsor:   Beijing Cancer HospitalRecruiting - verified July 2016Definitive chemoradiation is the standard treatment...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cryptococcus gattii s.l. infections are mostly encountered in healthy individuals, frequently affecting both lungs and the central nervous system (CNS).
Molecular characterisation and antifungal susceptibility of clinical Cryptococcus deuterogattii (AFLP6/VGII) isolates from Southern Brazil: AbstractCryptococcosis, caused by Cryptococcus gattii sensu lato, is an emerging disease that was initially found in (sub)tropical regions but recently expanded...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Staphylococcus aureus from a central venous catheter tip
Significance of the isolation of Staphylococcus aureus from a central venous catheter tip in the absence of concomitant bacteremia: a clinical approach: AbstractThe optimal approach following the isolation of Staphylococcus aureus from an intravascular catheter tip in the absence of concomitant bacteremia...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Nocardia abscessus-Associated Subcutaneous Infection
fection in a Patient with Non-Hodgkin’s Lymphoma: 2016-08-01T13-57-11ZSource: Disease and Molecular MedicineAhmet Karakaş, Abdullah Kılıç, Cumhur Artuk, Mutahher Akçaer, Duran Tok, Yüksel Yurttaş, Ömer Coşkun, Bülent Beşirbellioğlu.This paper describes primary subcutaneous infection caused by N. abscessus...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Dermatitis de contacto
Inducida por factores exógenos | Dermatitis de contacto: Autor: Rabia Sofia Rashid Tang Ngee Shim Fuente: BMJ 2016;353:i3299  Contact dermatitisEl término dermatitis se utiliza a menudo de forma intercambiable con el eczema. Sin embargo, la dermatitis atópica (eczema) es una condición inflamatoria endógena...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Menopause is associated with increased oxidative stress and decreased antioxidative activity
A comparative study of circulating plasma lipid components and superoxide dismutase activity in pre and postmenopausal women: 2016-08-01T09-32-43ZSource: International Journal of Research in Medical SciencesPriyanka Chaudhari, Rajeev S. Kushwaha, Shikha Raturi, Swati Naithani Shivani Sailwal, Sumita...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation
IJMS, Vol. 17, Pages 1232: Different cell types possess different miRNA expression profiles, and cell/tissue/organ-specific miRNAs (or profiles) indicate different diseases. Circulating miRNA is either actively secreted by living cells or passively released during cell death. Circulating cell/tissue/organ-specific...
      
   
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pulmonary Toxicity of Zinc Oxide Nanoparticles
IJMS, Vol. 17, Pages 1241: Evaluation of Pulmonary Toxicity of Zinc Oxide Nanoparticles Following Inhalation and Intratracheal Instillation: We conducted inhalation and intratracheal instillation studies of zinc oxide (ZnO) nanoparticles in order to examine their pulmonary toxicity. F344 rats were received...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Occupational noise exposure (
(The case of millitary personnel ): 2016-08-02T04-08-21ZSource: TAF Preventive Medicine BulletinHakan İstanbulluoğlu, Tayfun Kır.İnsanlar normal şartlarda, 20-20.000 Hz arası frekanstaki sesleri duyabilmektedir. Olumsuz etki yapma potansiyeline sahip, istenmeyen sesler gürültü olarak tanımlanmaktadır....
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Biological debridement with maggots in chronic wounds
 a case series: 2016-08-02T04-08-21ZSource: TAF Preventive Medicine BulletinŞenol Yıldız, Mehmet Tanyüksel, Engin Araz, Ömer Faruk Taner, Ömer Coşkun,Yüksel Yurttaş, Günalp Uzun The management of all wounds requires a holistic approach. After a holistic assessment, attention must be focused on the wound...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Tourette syndrome (TS) is characterized by motor and vocal tics, and frontal/basal-ganglia abnormalities.
A verbal strength in children with Tourette syndrome? Evidence from a non-word repetition taskvia Brain and LanguagePublication date: September 2016Source:Brain and Language, Volume 160Author(s): Cristina D. Dye, Matthew Walenski, Stewart H. Mostofsky, Michael T. UllmanTourette syndrome (TS) is characterized...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Structural brain correlates of listening and speaking in a second language
Neuroimaging of the bilingual brain: via Brain and LanguagePublication date: November 2016Source:Brain and Language, Volume 162Author(s): Patricia K. Kuhl, Jeff Stevenson, Neva M. Corrigan, Jasper J.F. van den Bosch, Dilara Deniz Can, Todd RichardsDiffusion tensor imaging was used to compare white matter...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Peanut allergy and isotretinoin
Should we be prescribing isotretinoin to patients with peanut allergies?AuthorsN. M. K. Spierings, J. Natkunarajah, A. Bansal, L. OstlerePublished Date20 August 2015Is isotretinoin treatment safe in patients with known peanut allergy?AuthorsL. Pierret, M. Grosber, J. GutermuthPublished Date30 July 2014IgE...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
The Persistence of Tinnitus after Acoustic Neuroma Surgery
Objective Examine possible prognostic factors for the persistence of tinnitus after acoustic neuroma resection. Study Design Case series with chart review. Setting Tertiary academic medical center. Subjects and Methods The records of 166 patients who underwent acoustic neuroma resection from...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Effects of Nasal Septum Deviation and Septoplasty on Cardiac Arrhythmia Risk
Objective Upper airway obstruction (UAO) can result in cardiac complications, including arrhythmias and sudden cardiac death. Nasal septum deviation (NSD) is a common cause of UAO. The aim of this study was to assess the risk of cardiac arrhythmias in patients with NSD. To assess this risk, we measured...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Analysis of Outcome Domains in Adult Cochlear Implantation: A Systematic Review
Objectives To determine the breadth of outcome domains used in the reporting of adult cochlear implant surgery for the purpose of registry and quality measure development. Data Sources Systematic review of randomized controlled trials. Review Methods In consultation with a medical librarian, search...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Impact of Sensory and Motor Defects on Oral Function in an Animal Model
Objective To evaluate the combined functional impact on swallowing of tongue sensory and motor loss using a rat model. Study Design Rats underwent selective neurectomies with transection of the motor (hypoglossal) nerve or motor and sensory (lingual) nerves. Postoperative functional parameters were...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
A Low-Cost Method of Ciliary Beat Frequency Measurement Using iPhone and MATLAB: Rabbit Study
Objectives (1) To determine ciliary beat frequency (CBF) using a consumer-grade cellphone camera and MATLAB and (2) to evaluate the effectiveness and accuracy of the proposed method. Study Design Prospective animal study. Setting Academic otolaryngology department research laboratory. Methods...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma
Objective Laryngeal cancer most commonly arises from the glottis. Comparable outcomes in survival have been shown in patients with early glottic squamous cell carcinoma treated with either surgery or radiotherapy. Study Design and Setting Administrative database study. Subjects and Methods The...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Cochlear Implantation in Canal Wall Down Mastoid Cavities
Cochlear implantation in canal wall down mastoid (CWD) cavities is fraught with the issue of how best to manage the mastoid cavity. Decision points include whether the external auditory meatus should be overclosed, whether the implantation should be staged, or even if the eustachian tube should be plugged....
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
The Role of Epstein-Barr Virus DNA Load and Serology as Screening Tools for Nasopharyngeal Carcinoma
Objective Screening for nasopharyngeal carcinoma (NPC) among family members has been advocated in endemic populations in view of significantly increased risks. We aimed to compare the role of Epstein-Barr virus (EBV) DNA load and EBV IgA serology as tools for screening patients with a first-degree...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Subepidermal Calcified Nodules of the Eyelid Differ in Children and Adults.
Purpose: Subepidermal calcified nodule of the eyelid is considered as one of the types of calcinosis cutis. It generally occurs in children, and is not known to be associated with systemic disease. The authors report histopathological and clinical findings in 14 cases of subepidermal calcified nodule...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
MRI- and CT-Compatible Polymer Laryngoscope: A Step toward Image-Guided Transoral Surgery
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OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Response to "Animal Model of Chronic Perforation Is Best for Eardrum Regeneration Using Biological Materials"
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OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes
Objective To investigate the efficacy, safety, and microbiology of a thermosensitive otic suspension of ciprofloxacin (OTO-201) in children with bilateral middle ear effusion undergoing tympanostomy tube placement. Study Design Two randomized, double-blind, sham-controlled phase 3 trials. Patients...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Laryngeal Preservation in Glottic Cancer: A Comparison of Hospital Charges and Morbidity among Treatment Options
Objective When total laryngectomy is not required, organ preservation surgery or radiotherapy is considered the standard of care for primary glottic cancer. These accepted treatment options are available for early and advanced glottic cancers due to equivalent locoregional control and survival rates....
OtoRhinoLaryngology by Alexandros G.Sfakianakis
A novel approach to cricoarytenoid joint injections: An anatomic study
Objectives To demonstrate a novel approach to cricoarytenoid joint (CAJ) injections. Study Design Anatomic feasibility study. Methods Five human cadaveric larynges providing 10 CAJ s were used to obtain trajectory measurements of a 27-gauge 1½-inch needle placed between the CAJ...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
A critical analysis of melanoma malpractice litigation: Should we biopsy everything?
Objectives/Hypothesis The aim of this study was to evaluate factors raised in malpractice litigation related to the diagnosis and management of melanoma and to further assess issues impacting outcome. Study Design Retrospective chart review. Methods The Westlaw legal database...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Blunt cerebrovascular injury following craniomaxillofacial fractures: A systematic review
Objectives Blunt cerebrovascular injury (BCVI) is a known sequela of high-energy craniomaxillofacial (CMF) trauma and can result in stroke or death. The objective of this systematic review is to 1) identify CMF trauma patients who may benefit from BCVI screening and 2) describe the optimal diagnostic...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Role of 18F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma
Objectives The purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC). Methods Following approval by the institutional...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Is there a group of patients at greater risk for hematoma following thyroidectomy? A systematic review and meta-analysis
Objective The purpose of this study was to perform a systematic review and meta-analysis to determine whether a difference exists in hematoma rates following thyroidectomy for any of the following subgroups of patients: Graves disease, toxic nodular goiter (TNG), and malignancy. Study Design...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Acoustic effects of the reconstructed lateral epitympanic wall in a temporal bone and clinical study
Objective Acoustic evaluation of reconstruction of the lateral epitympanic wall with bone or cartilage in a temporal bone study, and evaluation of audiometric data of patients who underwent cholesteatoma surgery with reconstruction of the lateral epitympanic wall with horseshoe-shaped cartilage....
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Impact of mandibular invasion on prognosis in oral squamous cell carcinoma four centimeters or less in size
Objectives/Hypothesis Previous studies have reported variable results for the impact of bone invasion on survival in oral cancer. It is unclear whether bone invasion in small (≤4 cm) squamous cell carcinomas (SCC) of the oral cavity is an independent adverse prognosticator. Our objective was to...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Book Review: Robotic Head and Neck Surgery: The Essential Guide
from #ORL via xlomafota13 on Inoreader http://ift.tt/2aol2DO via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Book Review: The Nose--Revision & Reconstruction
from #ORL via xlomafota13 on Inoreader http://ift.tt/2aLBt0j via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Angiolymphoid Hyperplasia With Eosinophilia Within a Vascular Malformation: Case Report and Review of the Literature
Objectives: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign microvascular proliferation tumor. The etiology of ALHE is unknown, though some hypothesize it occurs in reaction to focal trauma. This study presents a case of AHLE within a vascular malformation, its treatment, and...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Middle Cranial Fossa Dehiscence as an Incidental Finding on CT
Objectives: This retrospective chart review demonstrates that the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans increases with age. Methods: High-resolution temporal bone CT scans, which had been obtained for any otologic complaint, were reviewed independent...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Acclimation settings with identical or similar sensation and functional thresholds
Hypoglossal nerve stimulation with an activated implanted device does not awaken individuals from sleep once they have acclimated to the new sensation of the resulting tongue movement. This case report illustrates the importance of an acclimation period, allowing a patient to become accustomed to stimulation...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Advanced titration to treat a floppy epiglottis in selective upper airway stimulation
The following report presents a case of a patient with high residual apnea-hypopnea index at 6 months following implantation of an upper airway stimulation device who improved significantly after advanced titration via drug-induced sedated endoscopy by changing the electrode configuration for stimulation...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Role of 18F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma
Objectives The purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC). Methods Following approval by the institutional...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
A novel approach to cricoarytenoid joint injections: An anatomic study
Objectives To demonstrate a novel approach to cricoarytenoid joint (CAJ) injections. Study Design Anatomic feasibility study. Methods Five human cadaveric larynges providing 10 CAJ s were used to obtain trajectory measurements of a 27-gauge 1½-inch needle placed between the CAJ...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Blunt cerebrovascular injury following craniomaxillofacial fractures: A systematic review
Objectives Blunt cerebrovascular injury (BCVI) is a known sequela of high-energy craniomaxillofacial (CMF) trauma and can result in stroke or death. The objective of this systematic review is to 1) identify CMF trauma patients who may benefit from BCVI screening and 2) describe the optimal diagnostic...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Book Review: Robotic Head and Neck Surgery: The Essential Guide
http://ift.tt/2aol2DO
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
What Happens With Untreated Nasal Polyps Over Time? A 13-Year Prospective Study
Objectives: Nasal polyps are often seen in ENT practice, but little is known about the pathogenesis and the natural development. Our objective was to follow individuals with untreated nasal polyps prospectively, in terms of polyp size, symptoms, and respiratory function. Methods: Thirty-three individuals,...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Phenotype of a Belgian Family With 6p25 Deletion Syndrome
Background: The 6p25 deletion syndrome is one of the many syndromes with both hearing impairment as well as vision impairment. However, the audiometric characteristics and radiological findings of patients with 6p25 deletions are only scarcely described in literature. This study focused on characterizing...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Gustatory Dysfunction and Decreased Number of Fungiform Taste Buds in Patients With Chronic Otitis Media With Cholesteatoma
Objective: To compare the number of fungiform taste buds among patients with chronic otitis media (COM), those with pars flaccida retraction type cholesteatoma, and those with pars tensa retraction type cholesteatoma in combination with gustatory function. Methods: Thirty-seven patients with COM,...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Why the Gap in Hearing Loops and Access Options?
No abstract available http://ift.tt/2aojgm0
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Impact of mandibular invasion on prognosis in oral squamous cell carcinoma four centimeters or less in size
Objectives/Hypothesis Previous studies have reported variable results for the impact of bone invasion on survival in oral cancer. It is unclear whether bone invasion in small (≤4 cm) squamous cell carcinomas (SCC) of the oral cavity is an independent adverse prognosticator. Our objective was to...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Development of a Low-Cost, Noninvasive, Portable Visual Speech Recognition Program
Objectives: Loss of speech following tracheostomy and laryngectomy severely limits communication to simple gestures and facial expressions that are largely ineffective. To facilitate communication in these patients, we seek to develop a low-cost, noninvasive, portable, and simple visual speech recognition...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Middle Cranial Fossa Dehiscence as an Incidental Finding on CT
Objectives: This retrospective chart review demonstrates that the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans increases with age. Methods: High-resolution temporal bone CT scans, which had been obtained for any otologic complaint, were reviewed independent...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Angiolymphoid Hyperplasia With Eosinophilia Within a Vascular Malformation: Case Report and Review of the Literature
Objectives: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign microvascular proliferation tumor. The etiology of ALHE is unknown, though some hypothesize it occurs in reaction to focal trauma. This study presents a case of AHLE within a vascular malformation, its treatment, and...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Nissen Fundoplication for Laryngopharyngeal Reflux After Patient Selection Using Dual pH, Full Column Impedance Testing: A Pilot Study
Objectives: Prior studies demonstrate inconsistent diagnostic strategies for laryngopharyngeal reflux disease (LPR) patients who are offered laparoscopic Nissen fundoplication (Nissen). Superior symptom resolution outcomes are demonstrated in patients with accompanying typical gastroesophageal reflux...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Lateral Cricoarytenoid Release: Development of a Novel Surgical Treatment Option for Adductor Spasmodic Dysphonia in a Canine Laryngeal Model
Objective: To investigate the efficacy of a novel adductor muscle-releasing technique designed to decrease the force of vocal fold adduction, as a potential surgical therapy for patients with adductor spasmodic dysphonia (ADSD). Study Design: Experimental animal study. Methods: A canine laryngeal...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Acoustic effects of the reconstructed lateral epitympanic wall in a temporal bone and clinical study
Objective Acoustic evaluation of reconstruction of the lateral epitympanic wall with bone or cartilage in a temporal bone study, and evaluation of audiometric data of patients who underwent cholesteatoma surgery with reconstruction of the lateral epitympanic wall with horseshoe-shaped cartilage....
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Esophageal Swallowing Timing Measures in Healthy Adults During Videofluoroscopy
Objectives: Establishing the range of normal esophageal bolus transit times (ETT) is valuable when distinguishing pathology from normal variance, especially in elderly patients, and has not been documented for paste or pill. The aim of this study was to measure esophageal transit of liquid, paste,...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Safety of Monopolar Electrocautery in Patients With Cochlear Implants
Objective: The outcomes of 2 patients with cochlear implants (CIs) who underwent adenotonsillectomy (AT) with inadvertent use of monopolar cautery are presented. The safety data regarding monopolar cautery use in CI recipients is also reviewed. Study Design: This is a retrospective case series of...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
A critical analysis of melanoma malpractice litigation: Should we biopsy everything?
Objectives/Hypothesis The aim of this study was to evaluate factors raised in malpractice litigation related to the diagnosis and management of melanoma and to further assess issues impacting outcome. Study Design Retrospective chart review. Methods The Westlaw legal database...
   
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Book Review: The Nose--Revision & Reconstruction
http://ift.tt/2aLBt0j
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Composite Vascular Pedicled Middle Turbinate Flap for Reconstruction of Sellar Defects
Objectives: Herein, we describe our experience in simple harvest of the vascular pedicled middle turbinate flap (MTF) sufficient for sellar defect reconstruction. Methods: An anatomical feasibility study is done in 10 sides of 5 preserved injected cadaveric heads. The middle turbinate is separated...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Utility of the Highly Articulated Flex Robotic System for Head and Neck Procedures: A Cadaveric Study
Objective: Robotic head and neck surgery potentially reduces the morbidity associated with traditional open procedures. This study's goal was to employ a novel highly articulated robotic system (Flex Robotic System) for head and neck procedures, including a postauricular facelift approach thyroidectomy,...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Is there a group of patients at greater risk for hematoma following thyroidectomy? A systematic review and meta-analysis
Objective The purpose of this study was to perform a systematic review and meta-analysis to determine whether a difference exists in hematoma rates following thyroidectomy for any of the following subgroups of patients: Graves disease, toxic nodular goiter (TNG), and malignancy. Study Design...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Access to Health Care and Hearing Evaluation in US Adults
Objectives: To explore self-reported hearing testing access for adults in a nationally representative survey. Methods: Demographic and audiologic adult survey respondent variables in the National Health and Nutrition Examination Survey (NHANES) database 2011-2012 cohort were examined. Logistic regression...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Utility of the Highly Articulated Flex Robotic System for Head and Neck Procedures: A Cadaveric Study
Objective: Robotic head and neck surgery potentially reduces the morbidity associated with traditional open procedures. This study's goal was to employ a novel highly articulated robotic system (Flex Robotic System) for head and neck procedures, including a postauricular facelift approach thyroidectomy,...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Access to Health Care and Hearing Evaluation in US Adults
Objectives: To explore self-reported hearing testing access for adults in a nationally representative survey. Methods: Demographic and audiologic adult survey respondent variables in the National Health and Nutrition Examination Survey (NHANES) database 2011-2012 cohort were examined. Logistic regression...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Development of a Low-Cost, Noninvasive, Portable Visual Speech Recognition Program
Objectives: Loss of speech following tracheostomy and laryngectomy severely limits communication to simple gestures and facial expressions that are largely ineffective. To facilitate communication in these patients, we seek to develop a low-cost, noninvasive, portable, and simple visual speech recognition...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
What Happens With Untreated Nasal Polyps Over Time? A 13-Year Prospective Study
Objectives: Nasal polyps are often seen in ENT practice, but little is known about the pathogenesis and the natural development. Our objective was to follow individuals with untreated nasal polyps prospectively, in terms of polyp size, symptoms, and respiratory function. Methods: Thirty-three individuals,...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Esophageal Swallowing Timing Measures in Healthy Adults During Videofluoroscopy
Objectives: Establishing the range of normal esophageal bolus transit times (ETT) is valuable when distinguishing pathology from normal variance, especially in elderly patients, and has not been documented for paste or pill. The aim of this study was to measure esophageal transit of liquid, paste,...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Why the Gap in Hearing Loops and Access Options?
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aojgm0 via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
A Solution to Audiologist Shortage
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aoieXf via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Embracing the Enigma of Auditory Processing Disorder
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aoit4n via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
The Promise of Smartphone Apps for Hearing Tests
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2anDNau via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Trade Talk: A Q&A with Steve Eagon
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aojlGl via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Symptom: Conductive Hearing Loss
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aoiWDG via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
A Battle Won: CMS Approves Cochlear Implant-related Reimbursements
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aoiZ2A via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Thirty Million Words
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OtoRhinoLaryngology by Alexandros G.Sfakianakis
Views and Vision
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aoiWna via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
A Quest for Quality: Closing Contrasts Between Prosthetic and Normal Hearing
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aoiR3a via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
mHealth Improves Access to Community-based Hearing Care
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aoiDsD via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Couples’ Experience of Sensory Loss: A Research and Rehabilitation Imperative
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aLzlFN via IFTTT
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Manufacturers News
No abstract available from #Audiology via xlomafota13 on Inoreader http://ift.tt/2aLzhGb via IFTTT
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Reduction malarplasty by bidirectional wedge ostectomy or two percutaneous osteotomies according to zygoma protrusion type
Reduction malarplasty to correct prominent malar complex is popular in Asians. Despite the popularity of reduction malarplasty, most of the surgical methods applied are not selected according to the degree of zygoma protrusion. In this study, we analyzed the effectiveness of two different surgical procedures...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Rare compound heterozygosity involving dominant and recessive mutations of GJB2 gene in an assortative mating hearing impaired Indian family
Abstract Connexin 26 (Cx-26), a gap junction protein coded by GJB2 gene, plays a very important role in recycling of potassium ions, one of the vital steps in the mechanotransduction process of hearing. Mutations in the GJB2 gene have been associated with both autosomal recessive as well as dominant...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Seafloor sound-speed profile characterization with non-parallel layering by the image source method: Application to CLUTTER'09 campaign data
The image source method was originally developed to estimate sediment sound speed as a function of depth assuming plane-layered sediments. Recently, the technique was extended to treat dipping, i.e., non-parallel layers and was tested using synthetic data. Here, the technique is applied to measured...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Optimal Duration for Voice Rest After Vocal Fold Surgery: Randomized Controlled Clinical Study
Voice rest is commonly recommended after phonomicrosurgery to prevent worsening of vocal fold injuries. However, the most effective duration of voice rest is unknown. Recently, early vocal stimulation was recommended as a means to improve wound healing. The purpose of this study is to examine the optimal...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Transcultural Adaptation and Validation of the German Version of the Vocal Tract Discomfort Scale
Currently, there is no standardized German questionnaire to assess vocal tract discomfort in voice patients. The aim of this study was to evaluate the internal consistency, reliability, and validity of the German version of the Vocal Tract Discomfort (VTD) Scale. http://ift.tt/2aN9XfX
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
The development of a liquid biopsy for head and neck cancers
Publication date: October 2016Source:Oral Oncology, Volume 61 Author(s): Henri Schmidt, Arutha Kulasinghe, Liz Kenny, Chamindie Punyadeera Developing non-invasive diagnostic tools in the field of head and neck oncology has been a challenge. Analysis of circulating tumour derivatives in a patient's...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
When in doubt, extubate the patient
By Bradley Dean Following the 2013 death of Drew Hughes, a lawsuit was filed alleging the hospital and/or it's employees, "failed to keep Drew Hughes properly sedated and restrained; failed to properly re-intubate Andrew Davis Hughes during the transport; failed to perform standard objective tests to...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation
To date, few inhibitory signals for ILC2s have been described. Our study demonstrates that miR-155 is required for allergen-induced ILC2 expansion and IL-33 production in the lung, and that exogenous IL-33 administration is not sufficient to induce ILC2s in miR-155-/- mice. http://ift.tt/2aEiN08
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
The development of a liquid biopsy for head and neck cancers
Head and neck squamous cell carcinomas (HNSCCs) account for the 7th most common cancer globally and arise from multiple anatomical sites [1,2]. Known risk factors for HNSCCs include tobacco exposure, alcohol consumption, betel nut chewing and infection with oncogenic viruses such as Epstein-Barr virus...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
A parametric vocal fold model based on magnetic resonance imaging
This paper introduces a parametric three-dimensional body-cover vocal fold model based on magnetic resonance imaging (MRI) of the human larynx. Major geometric features that are observed in the MRI images but missing in current vocal fold models are discussed, and their influence on vocal fold vibration...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
On the completeness and the linear dependence of the Cartesian multipole series in representing the solution to the Helmholtz equation
The (Cartesian) multipole series, i.e., the series comprising monopole, dipoles, quadrupoles, etc., can be used, as an alternative to the spherical or cylindrical wave series, in representing sound fields in a wide range of problems, such as source radiation, sound scattering, etc. The proofs of the...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Prevention of Bisphosphonate-Related Osteonecrosis of the Jaws in Patients with Prostate Cancer Treated with Zoledronic acid – a prospective study over 6 years
To explore the preventive effect of a prophylactic oral and maxillofacial treatment to reduce bisphosphonate associated necrosis of the jaws (BRONJ) in metastatic prostate cancer (PC) patients treated with zoledronic acid (4.0 mg i.v./months). http://ift.tt/2avsBYx
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Use of a modified high submandibular approach to treat condylar base fractures: Experience with 44 consecutive cases treated in a single institution
The aim of this article is to present our experience treating fractures of the condylar base with a modification of the high submandibular approach (HSA). http://ift.tt/2aHG034
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
The Efficacy of Intra-Alveolar 0.2% Chlorhexidine Gel on Alveolar Osteitis: A Meta-Analysis
Abstract Objectives The objective of this meta-analysis was to assess the effect of 0.2% chlorhexidine gel in preventing alveolar osteitis following mandibular third molar extraction(s). Methods PubMed, Cochrane Library, Embase, Web of Science, Science Direct and the references of identified...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Orbital Metastasis of Breast Cancer Mimicking Invasive Fungal Rhinosinusitis
Introduction. A range of traumatic, vascular, inflammatory, infectious, and neoplastic processes can affect the orbit and its structures. In the area of otolaryngology, the rhino-orbital-cerebral involvement of invasive fungal rhinosinusitis can affect the orbit, which may look like initially a rhinosinusitis...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Shifts in frequency-modulated pulses recorded during an encounter with Blainville's beaked whales (Mesoplodon densirostris)
Echolocation signals produced by beaked whales (family: Ziphiidae) include frequency-modulated (FM) pulses that appear to have species-specific characteristics. To date there has been no established evidence that a single species of beaked whale might produce more than one type of FM pulse. In 2014...


Cancer by Sfakianakis G.Alexandros
Enhancing PD-1 Blockade in Solid Tumors [News in Brief]
A phase I study indicates that the combination of utomilumab, an investigational antibody that binds CD137, plus pembrolizumab is safe and well tolerated, yielding sustained responses in patients with various solid cancers. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aedINW via IFTTT
Cancer by Sfakianakis G.Alexandros
UPF1 Mutations Suppress Nonsense-Mediated RNA Decay in IMT [Tumorigenesis]
Inflammatory myofibroblastic tumors (IMT) harbor mutations in nonsense-mediated RNA decay gene UPF1. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aYKj7g via IFTTT
Cancer by Sfakianakis G.Alexandros
A Ubiquitin-Independent Function of CRBN Mediates the Response to IMiDs [Myelodysplastic Syndrome]
CRBN promotes CD147–MCT1-mediated antitumor activity in response to IMiDs. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aYKek4 via IFTTT
Cancer by Sfakianakis G.Alexandros
Pancreatic Cancer Survival Increases with Chemo Combo [News in Brief]
For patients able to have surgery for pancreatic cancer, the adjuvant use of gemcitabine plus capecitabine, instead of gemcitabine alone, leads to a significant improvement in 5-year survival, according to results of the ESPAC-4 trial. The finding will likely change the standard of care for these patients....
Cancer by Sfakianakis G.Alexandros
Biomarker-Driven Treatments Yield Better Results [News in Brief]
According to a meta-analysis of 351 phase I trials, choosing a therapy based on the abnormalities that drive a tumor yields higher response rates than therapeutic selections that aren’t biomarker-driven. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aee8Uu via IFTTT
Cancer by Sfakianakis G.Alexandros
DRD4 Selectively Promotes Glioblastoma Stem Cell Growth [Glioblastoma]
Dopamine receptor D4 (DRD4) is a potential therapeutic target in glioblastoma stem cells. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aYK3Fy via IFTTT
Cancer by Sfakianakis G.Alexandros
RASSF1A Represses TGF{beta} Oncogenic Signaling via YAP1/SMAD2 Translocation [Signaling]
TGFβ triggers RASSF1A ubiquitination to drive SMAD2-mediated transcription of TGFβ target genes. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aYKLCN via IFTTT
Cancer by Sfakianakis G.Alexandros
Tumor Profiling: Adding Proteomics to Genomics [News in Brief]
Researchers have used mass spectrometry to conduct proteomic analyses of 77 genomically characterized breast tumors. Through this approach, they’ve uncovered functional consequences of somatic mutations. For instance, EGFR overexpression in basal-like breast cancer is potentially driven by the loss of...
Cancer by Sfakianakis G.Alexandros
Brain Tumors Under Therapy Undergo Highly Branched Clonal Evolution [Brain Tumors]
Glioblastomas exhibit highly branched, treatment-specific clonal evolution patterns. from Cancer via xlomafota13 on Inoreader http://ift.tt/2arSA4V via IFTTT
Cancer by Sfakianakis G.Alexandros
Combining Antigen-Specific CTLs with Ipilimumab Is Effective in Melanoma [Immunotherapy]
MART1-specific CTLs followed by ipilimumab induce durable tumor regression in patients with melanoma. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aYK8ZO via IFTTT
Cancer by Sfakianakis G.Alexandros
Blocking PD-1 in Tumors with Faulty DNA Repair [News in Brief]
A phase II study shows that DNA mismatch repair deficiency can render tumors highly sensitive to the PD-1 inhibitor pembrolizumab. Patients with a range of solid tumors, including colorectal and endometrial cancers, with the deficiency responded well and durably to immune checkpoint blockade, with minimal...
Cancer by Sfakianakis G.Alexandros
First-Line Atezolizumab Effective in Bladder Cancer [News in Brief]
Results from a phase II study indicate that the PD-L1 inhibitor atezolizumab, recently approved for advanced bladder cancer that’s refractory to standard platinum chemotherapy, is effective as first-line therapy for this disease. Durable responses to atezolizumab were seen in nearly a quarter of the...
Cancer by Sfakianakis G.Alexandros
Antibody Improves Survival in Gastric Cancer [News in Brief]
Results from a randomized phase II study indicate that adding the experimental antibody IMAB362, which targets the tight junction protein claudin18.2, to standard chemotherapy is more effective than chemotherapy alone in previously untreated patients with advanced gastric cancer. IMAB362 extended progression-free...
Cancer by Sfakianakis G.Alexandros
The Cytotoxic Effects of Lenalidomide Are Calcium- and Calpain-Dependent [Myelodysplastic Syndrome]
Calcium metabolism gene GPR68 mediates lenalidomide sensitivity in myelodysplastic syndrome (MDS). from Cancer via xlomafota13 on Inoreader http://ift.tt/2aqOrLF via IFTTT
Cancer by Sfakianakis G.Alexandros
The Cereblon Modulator CC-885 Exhibits Antitumor Activity [Structural Biology]
A common motif likely promotes binding of substrates, including GSPT1, to cereblon. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aqOWFg via IFTTT
Cancer by Sfakianakis G.Alexandros
High-Level Clonal FGFR2 Amplification and Treatment Response [Research Articles]
FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified cancers is unknown. In a translational clinical trial, we show that gastric cancers with high-level clonal FGFR2 amplification have a high response rate to the selective FGFR inhibitor AZD4547,...
Cancer by Sfakianakis G.Alexandros
RANKL Blockade May Aid Breast Cancer Prevention in High-Risk Patients [Breast Cancer]
Inhibition of RANKL signaling may prevent breast tumorigenesis in BRCA1-mutation carriers. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aMHMRQ via IFTTT
Cancer by Sfakianakis G.Alexandros
Obesity Promotes Desmoplasia in PDAC [Research Articles]
It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired...
Cancer by Sfakianakis G.Alexandros
Targeting DOT1L May Reverse Leukemogenic Effects of Mutant DNMT3A [Leukemia]
Mutant DNMT3A promotes leukemogenesis via aberrant epigenetic induction of stem-cell genes. from Cancer via xlomafota13 on Inoreader http://ift.tt/2arSH0u via IFTTT
Cancer by Sfakianakis G.Alexandros
MYC Inhibition Plus p53 Stabilization Targets Leukemic Stem Cells [Leukemia]
MYC and p53 are critical nodes in chronic myeloid leukemia (CML) leukemic stem cells. from Cancer via xlomafota13 on Inoreader http://ift.tt/2aOLgQz via IFTTT
Cancer
Exercise Promotion in Geriatric Oncology
Abstract Evidence of the benefits of exercise for people with cancer from diagnosis through survivorship is growing. However, most cancers occur in older adults and little exercise advice is available for making specific recommendations for older adults with cancer. Individualized exercise prescriptions...
Cancer
Immune Checkpoint Blockade: A New Era for Non-Small Cell Lung Cancer
Abstract Despite better understanding of it's molecular biology, non-small cell lung cancer (NSCLC) remains a challenging disease to treat. Unfortunately, treatment options are still very limited and prognosis for advanced disease is poor. Immune surveillance plays a crucial role in a host's defence...
Cancer
Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer
Abstract The role of adjuvant chemotherapy in stage T2-T3N0 colon cancer (CC) is controversial and there are currently no reliable factors allowing for individual selection of patients with high risk of relapse for such therapy. We searched for microRNA-based signature with prognostic significance in...
Cancer by Sfakianakis G.Alexandros
Exercise Promotion in Geriatric Oncology
Abstract Evidence of the benefits of exercise for people with cancer from diagnosis through survivorship is growing. However, most cancers occur in older adults and little exercise advice is available for making specific recommendations for older adults with cancer. Individualized...
Cancer by Sfakianakis G.Alexandros
Immune Checkpoint Blockade: A New Era for Non-Small Cell Lung Cancer
Abstract Despite better understanding of it’s molecular biology, non-small cell lung cancer (NSCLC) remains a challenging disease to treat. Unfortunately, treatment options are still very limited and prognosis for advanced disease is poor. Immune surveillance plays a crucial role...
Cancer by Sfakianakis G.Alexandros
Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer
Abstract The role of adjuvant chemotherapy in stage T2-T3N0 colon cancer (CC) is controversial and there are currently no reliable factors allowing for individual selection of patients with high risk of relapse for such therapy. We searched for microRNA-based signature with prognostic...
Cancer by Sfakianakis Alexandros
Exercise Promotion in Geriatric Oncology
Abstract Evidence of the benefits of exercise for people with cancer from diagnosis through survivorship is growing. However, most cancers occur in older adults and little exercise advice is available for making specific recommendations for older adults with cancer. Individualized exercise prescriptions...
Cancer by Sfakianakis Alexandros
Immune Checkpoint Blockade: A New Era for Non-Small Cell Lung Cancer
Abstract Despite better understanding of it's molecular biology, non-small cell lung cancer (NSCLC) remains a challenging disease to treat. Unfortunately, treatment options are still very limited and prognosis for advanced disease is poor. Immune surveillance plays a crucial role in a host's defence...
Cancer by Sfakianakis Alexandros
Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer
Abstract The role of adjuvant chemotherapy in stage T2-T3N0 colon cancer (CC) is controversial and there are currently no reliable factors allowing for individual selection of patients with high risk of relapse for such therapy. We searched for microRNA-based signature with prognostic significance in...
Cancer
Exhaled Breath Condensate as a Source of Biomarkers for Lung Carcinomas. A Focus on Genetic and Epigenetic Markers – A Mini-Review
Abstract Lung carcinoma is one of the most common causes of cancer-related mortality worldwide. It is an aggressive tumor, often diagnosed at an advanced stage when treatment options are limited. Currently, the importance of detection and assessment of various genetic alterations in cancer is recognized...
Head and Neck Cancers by Alexandros G. Sfakianakis
Cochlear Implantation in Canal Wall Down Mastoid Cavities
Cochlear implantation in canal wall down mastoid (CWD) cavities is fraught with the issue of how best to manage the mastoid cavity. Decision points include whether the external auditory meatus should be overclosed, whether the implantation should be staged, or even if the eustachian tube should be plugged....
Head and Neck Cancers by Alexandros G. Sfakianakis
Laryngeal Preservation in Glottic Cancer: A Comparison of Hospital Charges and Morbidity among Treatment Options
Objective When total laryngectomy is not required, organ preservation surgery or radiotherapy is considered the standard of care for primary glottic cancer. These accepted treatment options are available for early and advanced glottic cancers due to equivalent locoregional control and survival rates....
Head and Neck Cancers by Alexandros G. Sfakianakis
Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes
Objective To investigate the efficacy, safety, and microbiology of a thermosensitive otic suspension of ciprofloxacin (OTO-201) in children with bilateral middle ear effusion undergoing tympanostomy tube placement. Study Design Two randomized, double-blind, sham-controlled phase 3 trials. Patients...
Head and Neck Cancers by Alexandros G. Sfakianakis
The Role of Epstein-Barr Virus DNA Load and Serology as Screening Tools for Nasopharyngeal Carcinoma
Objective Screening for nasopharyngeal carcinoma (NPC) among family members has been advocated in endemic populations in view of significantly increased risks. We aimed to compare the role of Epstein-Barr virus (EBV) DNA load and EBV IgA serology as tools for screening patients with a first-degree...
Head and Neck Cancers by Alexandros G. Sfakianakis
Variations in lung lymphatic drainage into the inferior tracheobronchial lymph nodes junction: Applications in lung cancer
Astract Introduction The group of inferior tracheobronchial lymph nodes (ITB) is a lymphatic junction through which the lymph from both lungs is carried. Lymphatic activity in this area can be used to assess the lymphatic spreading of lung cancers. Our aim was to quantify lymph drainage from...
Cancer by Sfakianakis Alexandros
Exhaled Breath Condensate as a Source of Biomarkers for Lung Carcinomas. A Focus on Genetic and Epigenetic Markers – A Mini-Review
Abstract Lung carcinoma is one of the most common causes of cancer-related mortality worldwide. It is an aggressive tumor, often diagnosed at an advanced stage when treatment options are limited. Currently, the importance of detection and assessment of various genetic alterations in cancer is recognized...
Cancer by Sfakianakis G.Alexandros
Exhaled Breath Condensate as a Source of Biomarkers for Lung Carcinomas. A Focus on Genetic and Epigenetic Markers – A Mini-Review
Abstract Lung carcinoma is one of the most common causes of cancer-related mortality worldwide. It is an aggressive tumor, often diagnosed at an advanced stage when treatment options are limited. Currently, the importance of detection and assessment of various genetic alterations in cancer is recognized...
Head and Neck Cancers by Alexandros G. Sfakianakis
Topographical anatomy of cricothyroid membrane and its relation with invasive airway access
Abstract Cricothyroidotomy is a surgical procedure involving penetration through the skin and cricothyroid membrane to maintain airway patency during life-threatening emergency conditions. Complications such as bleeding and laryngeal stenosis can result from it. Our aim in this study was to identify...
Head and Neck Cancers by Alexandros G. Sfakianakis
Effect of different implant placement depths on crestal bone levels and soft tissue behavior: a randomized clinical trial
Abstract Objectives This randomized clinical trial analyzed crestal bone changes and soft tissue dimensions surrounding implants with an internal tapered connection placed in the mandible anterior region at different depths (equicrestal and subcrestal). Materials and methods Eleven edentulous...
Head and Neck Cancers by Alexandros G. Sfakianakis
Regulation of Pancreatic Alpha Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) in vitro
Endocrinology, Early Release. http://ift.tt/2areFO1
Head and Neck Cancers by Alexandros G. Sfakianakis
Cyclooxygenase inhibitors as a new therapeutic strategy in small bowel transplantation.
BACKGROUND: The long-term outcome of intestinal transplantations is still not favorable, which is partly due to the intestinal susceptibility to ischemia. There are several indications that the inflammatory response to ischemia-reperfusion injury is mediated by cyclooxygenases and that their inhibition...
Head and Neck Cancers by Alexandros G. Sfakianakis
Establishing biomarkers in transplant medicine: a critical review of current approaches.
Although the management of kidney transplant recipients has greatly improved over recent decades, the assessment of individual risks remains highly imperfect. Individualized strategies are necessary to recognize and prevent immune complications early and to fine-tune immunosuppression, with the overall...
Head and Neck Cancers by Alexandros G. Sfakianakis
Association between delayed graft function and graft loss in donation after cardiac death kidney transplants - a paired kidney registry analysis.
Background: Delayed graft function (DGF) is an established complication after donation after cardiac death (DCD) kidney transplants, but the impact of DGF on graft outcomes is uncertain. To minimize donor variability and bias, a paired donor kidney analysis was undertaken where 1 kidney developed DGF...
Head and Neck Cancers by Alexandros G. Sfakianakis
Kidney Biopsies May Help Predict Renal Function following Liver Transplantation.
Background: Renal biopsy has been proposed to determine the cause or reversibility of renal failure for patients with ESLD and may be useful in the kidney allocation. Nevertheless, little data exists to validate the usefulness of kidney biopsies in this patient population. Methods: We evaluated the utility...
Head and Neck Cancers by Alexandros G. Sfakianakis
Correlates and Outcomes of Posttransplant Smoking in Solid Organ Transplant Recipients: A Systematic Literature Review and Meta-analysis.
Background: Despite smoking being an absolute or relative contraindication for transplantation, about 11-40% of all patients continue or resume smoking posttransplant. This systematic review with meta-analysis investigated the correlates and outcomes associated with smoking after solid organ transplantation....
Head and Neck Cancers by Alexandros G. Sfakianakis
Eight Hour Continuous Normothermic Ex Vivo Kidney Perfusion is a Safe Preservation Technique for Kidney Transplantation: A New Opportunity for the Storage, Assessment and Repair of Kidney Grafts.
Background: Hypothermic kidney storage causes preservation injury and is poorly tolerated by renal grafts. We investigated whether static cold storage (SCS) can be safely replaced with a novel technique of pressure-controlled normothermic ex vivo kidney perfusion (NEVKP) in heart-beating donor kidney...
Head and Neck Cancers by Alexandros G. Sfakianakis
FGF-23 Klotho Axis: Will intervention improve Kidney Transplant outcomes?.
No abstract available http://ift.tt/2aexwAp
Head and Neck Cancers by Alexandros G. Sfakianakis
The Effects of Valsartan on Renal Klotho Expression and Oxidative stress in Alleviation of Cyclosporine Nephrotoxicity.
Background: Nephrotoxicity side effect of the immunosuppressive drug, Cyclosporine-A (CsA), can be a major issue in transplantation medicine. CsA-induced nephrotoxicity is multifactorial but oxidative stress has a critical role in this process. It has been demonstrated that Valsartan (Val) as an angiotensin...
Head and Neck Cancers by Alexandros G. Sfakianakis
How qualitative research informs clinical and policy decision making in transplantation: a review.
Patient-centred care is no longer just a buzzword. It is now widely touted as a cornerstone in delivering quality care across all fields of medicine. However, patient-centred strategies and interventions necessitate evidence about patients' decision-making processes, values, priorities, and needs. Qualitative...        

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