08:41
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Should we consider devolution of “head and neck” surgery from the specialties of oral and maxillofacial surgery; ear, nose, and throat surgery; and plastic surgery?: In the United Kingdom the practice of vascular surgery has now become recognised as the tenth independent surgical specialty by the Royal...
08:41
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Impact of orthognathic surgery on oral health-related quality of life in patients with jaw deformities: The purpose of this study was to clarify the impact of orthognathic surgery on oral health-related quality of life (OHRQOL) in patients with jaw deformities. The subjects were 65 patients (21 males...
08:41
OtoRhinoLaryngology - Alexandros G. Sfakianakis
in Port Harcourt, Nigeria: Introduction. Adenoid hypertrophy (AH) is a common childhood disorder. Adenoid plays a significant role in the pathogenesis of otitis media with effusion (OME). The aim of this study is to critically appraise the tympanometric finding among children with adenoid hypertrophy...
08:40
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Non Calcifying Type of Calcifying Epithelial Odontogenic Tumor: An Unusual Case Report with Special Emphasis on Histogenesis of Calcifications: AbstractCalcifying epithelial odontogenic tumour also known as Pindborg tumour, is a rare benign odontogenic neoplasm of locally aggressive behavior. It is thought...
08:40
OtoRhinoLaryngology - Alexandros G. Sfakianakis
A Systematic Review of Unmet Information and Psychosocial Support Needs of Adults Diagnosed with Thyroid Cancer: Thyroid , Vol. 0, No. 0. Author informationYong Gyu Hyun,1* Ahmad Alhashemi,2* Rouhi Fazelzad,3 Alyse S. Goldberg,2 David P. Goldstein,4 andAnna M. Sawka51Department of Volunteer Resources,...
08:38
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Comparison of survival between radiation therapy and trans-oral laser microsurgery for early glottic cancer patients; a retrospective cohort studyby R. J. De Santis, I. Poon, J. Lee, I. Karam, D. J. Enepekides and K. M. Higgins via Journal of Otolaryngology - Head & Neck SurgeryR. J. De Santis,I. Poon,J. Lee,I. Karam,D. J. Enepekides andK. M. HigginsEmail...
08:33
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Vitamin D Deficiency and Rheumatoid Arthritis: AbstractVitamin D (VitD) is a hormone primarily synthesized in human skin under the stimulation of ultraviolet radiation. Beyond its endocrine role in bone metabolism, VitD is endowed with remarkable immunomodulatory properties. The effects of VitD on the...
08:33
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Comparison of results of graft uptake using tragal cartilage perichondrium composite graft versus temporalis fascia in patients undergoing surgery for chronic otitis media – squamous type:S. Khalilullah,Shankar P. ShahEmail author,D. Yadav,R. P. Shrivastav andH. BhattaraiHead & Face Medicine201612:26DOI: 10.1186/s13005-016-0123-z©...
08:31
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Relative velocity measurement from the spectral phase of a match-filtered linear frequency modulated pulse: Linear frequency modulated signals are commonly used to perform underwater acoustic measurements since they can achieve high signal-to-noise ratios with relatively low source levels....
08:31
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cochlear hearing loss and the detection of sinusoidal versus random amplitude modulation: This study assessed the effect of cochlear hearing loss on detection of random and sinusoidal amplitude modulation. Listeners with hearing loss and normal-hearing listeners (eight per group) generated...
08:31
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Acoustic radiation force expressed using complex phase shifts and momentum-transfer cross sections: Acoustic radiation force is expressed using complex phase shifts of partial wave scattering functions and the momentum-transfer cross section, herein incorporated into acoustics...
08:30
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Experimental validation of a three-dimensional reduced-order continuum model of phonation: Due to the complex nature of the phonation process, a one-dimensional (1D) glottal flow description is often used in current phonation models. Although widely used in voice research, these 1D flow-based phonation...
08:30
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Surgical Treatment of via World NeurosurgeryPublication date: October 2016Source:World Neurosurgery, Volume 94Author(s): Si Zhang, Wenke Liu, Xuhui Hui, Chao YouBackgroundSurgical treatment of giant vestibular schwannomas (GVS) is challenging. The philosophy of incomplete tumor resection may balance...
08:30
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin-exacerbated respiratory disease: an evidence-based review with recommendations: BackgroundChronic rhinosinusitis (CRS) in aspirin-exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation...
08:29
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Case series of three-dimensional printing technology applied in complex craniofacial deformity surgery: Derick A Mendonca, Vybhav Deraje, Rajendra S Gujjalanavar, Swaroop GopalJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):88-94Introduction: Three-dimensional (3D) printing (additive...
08:29
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Application of buccal fat pad for lining of lateral defect in cleft palate repair and review of literature: Parit S Ladani, Hermann F SailerJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):63-66Purpose: To discuss the advantages of pedicle buccal fat pad flaps used to cover areas of exposed...
08:29
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Perceptual and instrumental analysis of hypernasality in children with repaired cleft palate: Henna Raunak Seth Tak, Aarti Pushkar Waknis, Sneha Prakash KulkarniJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):67-72Context: Hypernasality is a frequently encountered problem in the speech...
08:24
OtoRhinoLaryngology - Alexandros G. Sfakianakis
What Are Craniofacial Syndromes?Craniofacial (cranio=head/skull; facial=face) syndromes vary considerably in type, level of severity and physical symptoms. Syndromes always include a cluster of symptoms, most often affecting the form, function and, appearance of the head, face, and neck region. Differences...
08:22
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Airway, Lungs and ChestAllergies and AsthmaAutism and Developmental DisordersBehavioral Issues and DisordersBlood and Bone MarrowBones, Muscles and JointsBrain and Nervous SystemCancerCommon Infant and Childhood Conditions and InjuriesCraniofacial Anomalies and DisordersDiabetes and Endocrine SystemDigestive...
08:14
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Goldenhar syndromeFrom Wikipedia, the free encyclopediaGoldenhar syndromeClassification and external resourcesSpecialtymedical geneticsICD-10Q87.0OMIM164210DiseasesDB31292MeSHD006053Goldenhar syndrome (also known as Oculo-Auriculo-Vertebral (OAV) syndrome) is a rare congenital defect characterized by...
08:10
OtoRhinoLaryngology - Alexandros G. Sfakianakis
A rare combination of Tessier 2 cleft with Goldenhar syndrome: Vybhav Deraje, Rajeev B AhujaJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):100-102The incidence of rare craniofacial clefts ranges from 1.43 to 4.85/100,000 live births. Most craniofacial centers report an incidence of...
08:10
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Comparison of oral and dental health status in patients with or without cleft lip and palate deformities undergoing orthodontic treatment: Lakshmi Chandran Nair, Arun Kumar Singh, Veerendra Prasad, Kishore KumarJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):73-76Objective: To compare...
08:10
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Does relative maxillary arch constriction worsen with growth in patients with cleft lip and palate? A pilot study: Nafeesa Qureshi, Grant T McIntyre, Peter A MosseyJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):77-82Objective: To evaluate relative maxillary arch constriction in patients...
08:10
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Does cleft palate repair reduce the incidence of middle ear pathology?: Sunil Kumar Rout, Sudarsan Baliarsing, Manoj Kumar Lath, Aparajita Debnath, Suresh Prasad DashJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):95-99Introduction: In an infant, cleft palate usually affects his/her...
08:09
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Comparative analysis of 6-0 nylon and 6-0 vicryl rapide in congenital unilateral cleft lip repair: JK Dayashankara Rao, Payal Luthra, Varun Arya, Vijay Siwach, Anil Sheorain, Priyanka MudgalJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):83-86Context: The type of suture material used...
08:09
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Tessier No. 3 incomplete cleft: Nasal reconstruction using turbinate mucosal flap: Abbas Asgharali Mistry, Burhanuddin Qayyumi, Taher Abbas Mistry, Chetan KardileJournal of Cleft Lip Palate and Craniofacial Anomalies 2016 3(2):103-106Facial clefts are extremely rare congenital deformities, especially...
08:09
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Neural Mechanisms Contributing to Dysphagia in Mouse Models: Investigative research into curative treatments for dysphagia is hindered by our incomplete understanding of the neural mechanisms of swallowing in health and disease. Development of translational research models is essential to bridge this...
08:09
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Effects of Continuous Positive Airway Pressure on Middle Ear Pressure and Acoustic Stapedial Reflex: ObjectiveThis study investigated the effects of continuous positive airway pressure (CPAP) on middle ear pressure and acoustic stapedial reflex and the correlation between CPAP and middle ear pressure.Study...
08:09
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Peritonsillar Abscess: Complication of Acute Tonsillitis or Webers Glands Infection?: ObjectiveTo review the literature concerning the 2 primary hypotheses put forth to explain the pathogenesis of peritonsillar abscess: "the acute tonsillitis hypothesis" (peritonsillar abscess is a complication of acute...
08:08
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Informed Consent in Pediatric Otolaryngology: What Risks and Benefits Do Parents Recall?: ObjectiveTo evaluate parental recall of surgical risks and benefits in pediatric otolaryngology and to assess for factors that may influence recall.Study DesignProspective cohort study.SettingAcademic pediatric...
08:08
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Quality of Life in Children with Hearing Impairment: Systematic Review and Meta-analysis: ObjectiveTo determine the impact of pediatric hearing loss (HL) on quality of life (QOL).Data SourcesA qualified medical librarian conducted a literature search for relevant publications that evaluate QOL in school-aged...
08:08
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Role of Surgery in Management of Samters Triad: A Systematic Review: ObjectiveAspirin-exacerbated respiratory disease (AERD) represents a severe form of chronic rhinosinusitis (CRS) characterized by nasal polyposis, bronchial asthma, and aspirin intolerance. This syndrome, known as Samter’s triad,...
08:08
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Persistence of Tinnitus after Acoustic Neuroma Surgery: ObjectiveExamine possible prognostic factors for the persistence of tinnitus after acoustic neuroma resection.Study DesignCase series with chart review.SettingTertiary academic medical center.Subjects and MethodsThe records of 166 patients who...
08:08
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Analysis of Outcome Domains in Adult Cochlear Implantation: A Systematic Review: ObjectivesTo determine the breadth of outcome domains used in the reporting of adult cochlear implant surgery for the purpose of registry and quality measure development.Data SourcesSystematic review of randomized controlled...
08:07
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Effects of Nasal Septum Deviation and Septoplasty on Cardiac Arrhythmia Risk: ObjectiveUpper airway obstruction (UAO) can result in cardiac complications, including arrhythmias and sudden cardiac death. Nasal septum deviation (NSD) is a common cause of UAO. The aim of this study was to assess the risk...
08:07
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Impact of Sensory and Motor Defects on Oral Function in an Animal Model: ObjectiveTo evaluate the combined functional impact on swallowing of tongue sensory and motor loss using a rat model.Study DesignRats underwent selective neurectomies with transection of the motor (hypoglossal) nerve or motor and...
08:07
OtoRhinoLaryngology - Alexandros G. Sfakianakis
A Low-Cost Method of Ciliary Beat Frequency Measurement Using iPhone and MATLAB: Rabbit Study: Objectives(1) To determine ciliary beat frequency (CBF) using a consumer-grade cellphone camera and MATLAB and (2) to evaluate the effectiveness and accuracy of the proposed method.Study DesignProspective animal...
08:07
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma: ObjectiveLaryngeal cancer most commonly arises from the glottis. Comparable outcomes in survival have been shown in patients with early glottic squamous cell carcinoma treated with either surgery or radiotherapy.Study...
08:07
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cochlear Implantation in Canal Wall Down Mastoid Cavities: Cochlear implantation in canal wall down mastoid (CWD) cavities is fraught with the issue of how best to manage the mastoid cavity. Decision points include whether the external auditory meatus should be overclosed, whether the implantation should...
08:07
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Laryngeal Preservation in Glottic Cancer: A Comparison of Hospital Charges and Morbidity among Treatment Options: ObjectiveWhen total laryngectomy is not required, organ preservation surgery or radiotherapy is considered the standard of care for primary glottic cancer. These accepted treatment options...
08:06
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes: ObjectiveTo investigate the efficacy, safety, and microbiology of a thermosensitive otic suspension of ciprofloxacin (OTO-201) in children with bilateral middle ear effusion undergoing tympanostomy tube...
08:06
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The Role of Epstein-Barr Virus DNA Load and Serology as Screening Tools for Nasopharyngeal Carcinoma
The Role of Epstein-Barr Virus DNA Load and Serology as Screening Tools for Nasopharyngeal Carcinoma: ObjectiveScreening for nasopharyngeal carcinoma (NPC) among family members has been advocated in endemic populations in view of significantly increased risks. We aimed to compare the role of Epstein-Barr...
08:06
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Retromaxillary Pneumatization of Posterior Ethmoid Air Cells: Novel Description and Surgical Implications: ObjectiveRetromaxillary pneumatization of posterior ethmoid (PE) air cells is an area that is yet to have appropriate description in rhinologic literature.Study DesignCase series with chart review.SettingTertiary...
08:06
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness: ObjectiveAggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence...
08:06
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pediatric Posttonsillectomy Hemorrhage: Demographic and Geographic Variation in Health Care Costs in the United States: ObjectiveTo examine variations in management of pediatric posttonsillectomy hemorrhage and associated costs from a national third-party payer perspective.Study DesignThe MarketScan...
08:05
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Biomechanics of Pharyngeal Deglutitive Function following Total Laryngectomy: ObjectivePostlaryngectomy, pharyngeal weakness, and pharyngoesophageal junction (PEJ) restriction are the candidate mechanisms of dysphagia. The aims were, in laryngectomees, whether (1) hypopharyngeal propulsion is reduced...
08:05
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Subepidermal Calcified Nodules of the Eyelid Differ in Children and Adults.: Purpose: Subepidermal calcified nodule of the eyelid is considered as one of the types of calcinosis cutis. It generally occurs in children, and is not known to be associated with systemic disease. The authors report histopathological...
08:05
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Acclimation settings with identical or similar sensation and functional thresholds: Hypoglossal nerve stimulation with an activated implanted device does not awaken individuals from sleep once they have acclimated to the new sensation of the resulting tongue movement. This case report illustrates the...
07:43
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Abstract Background Oropharyngeal dysphagia (OD) is a highly prevalent symptom in older people. Appropriate oropharyngeal sensory feedback is essential for safe and efficient swallowing. However, pharyngeal sensitivity decreases with advancing age and could play a fundamental role in the physiopathology...
06:37
OtoRhinoLaryngology by Alexandros G.Sfakianakis
IgG4-related disease is a newly recognized systemic disease, and its elucidation is progressing. However, little is known about its sinonasal manifestations. The aim of this study was to assess the olfaction of patients with IgG4-related disease. Twenty-five patients with IgG4-related disease underwent...
05:43
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Phonomicrosurgery is generally considered to be the treatment of choice for removing vocal fold polyps. However, specific techniques of voice therapy may represent, in selected cases and under certain conditions, a noninvasive therapeutic option for the treatment of such laryngeal lesions. The aim of...
08:49
Νευρολογία κ' Νευροχειρουργική
from Neurology via xlomafota13 on Inoreader http://ift.tt/2aAdVHq via IFTTT
08:49
Νευρολογία κ' Νευροχειρουργική
from Neurology via xlomafota13 on Inoreader http://ift.tt/2aMpKxB via IFTTT
08:48
Νευρολογία κ' Νευροχειρουργική
from Neurology via xlomafota13 on Inoreader http://ift.tt/2aMpQFF via IFTTT
08:48
Νευρολογία κ' Νευροχειρουργική
Background and Purpose— Thrombectomy, primarily with stent retrievers with or without adjunctive aspiration, provided clinical benefit across multiple prospective randomized trials. Whether this benefit is exclusive to stent retrievers is unclear. Methods— THERAPY (The Randomized, Concurrent Controlled...
08:38
Allergy Rhinology Immunology Asthma
Abstract Rhinitis is a multifactorial disease characterized by symptoms of sneezing, rhinorrhea, postnasal drip, and nasal congestion. Non-allergic rhinitis is characterized by rhinitis symptoms without systemic sensitization of infectious etiology. Based on endotypes, we can categorize non-allergic...
08:34
Νευρολογία κ' Νευροχειρουργική
Abstract Background The inframammary fold (IMF) incision is widely used in Western countries for breast augmentation surgery, whereas the axillary incision is the dominant approach used in China, because many Chinese surgeons believe that the Asian population has a higher risk of developing hypertrophic...
08:15
Λοίμωξη
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/2aMcoBg via IFTTT
08:15
Λοίμωξη
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/2ayPR7o via IFTTT
08:15
Λοίμωξη
Among 2,338 chronic hepatitis B patients followed during 2006-2013 in the Chronic Hepatitis Cohort Study, 78% had ≥1 alanine aminotransferase and 37% had ≥1 HBV DNA level assessed annually. Among cirrhotic patients, 46% never had hepatic imaging. Patients in this cohort were insufficiently monitored...
08:15
Λοίμωξη
Postmarketing cases of hepatitis B virus (HBV) reactivation during hepatitis C treatment have been reported. We analyzed serum samples from patients in a clinical trial of ledipasvir/sofosbuvir in Taiwan and Korea. Of the 173 patients enrolled, 103 (60%) had been previously infected with HBV. None showed...
08:15
Λοίμωξη
Our case-control study suggests that during 2010-11, seasonal influenza vaccination reduced the risk of influenza-associated hospitalizations by more than 50% among adults aged ≥50 years. Even in those aged ≥75 years, influenza vaccination was significantly effective in preventing influenza hospitalizations....
08:15
Λοίμωξη
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/2b1tTeD via IFTTT
08:12
Thyroid Disorders by Alexandros G.Sfakianakis
Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/2aM50WF via IFTTT
08:12
Thyroid Disorders by Alexandros G.Sfakianakis
Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/2ayIwVp via IFTTT
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Inhibitors of the Bone Morphogenetic Protein (BMP) Signaling Pathway: A Patent Review (2008-2015). Expert Opin Ther Pat. 2016 Aug 1; Authors: Hopkins CR Abstract INTRODUCTION: The bone morphogenetic protein (BMP) is a critical signaling pathway and plays a diverse role in embryonic pattern formation...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Severe neurological manifestations in an Egyptian patient with a novel frameshift mutation in the Glutaryl-CoA dehydrogenase gene. Metab Brain Dis. 2016 Aug 1; Authors: Moseilhy A, Hassan MM, El Abd HS, Mohammad SA, El Bekay R, Abdel-Motal UM, Ouhtit A, Zaki OK, Zayed H Abstract To characterize...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Bioactivity of Polyphenols: Preventive and Adjuvant Strategies toward Reducing Inflammatory Bowel Diseases-Promises, Perspectives, and Pitfalls. Oxid Med Cell Longev. 2016;2016:9346470 Authors: Kaulmann A, Bohn T Abstract Inflammatory bowel diseases (IBDs) are characterized by autoimmune and inflammation-related...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Mitochondrial Health in Aging and Age-Related Metabolic Disease. Oxid Med Cell Longev. 2016;2016:5831538 Authors: Sebastián D, Acín-Pérez R, Morino K PMID: 27478533 [PubMed - in process] http://ift.tt/2apb4lm
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxid Med Cell Longev. 2016;2016:1245049 Authors: Di Meo S, Reed TT, Venditti P, Victor VM Abstract There is significant evidence that, in living systems, free radicals and other reactive oxygen and nitrogen species play a...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Vitamin D2 suppresses amyloid-β 25-35 induced microglial activation in BV2 cells by blocking the NF-κB inflammatory signaling pathway. Life Sci. 2016 Jul 28; Authors: Raha S, Lee HJ, Yumnam S, Hong GE, Saralamma VV, Ha YL, Kim JO, Kim YS, Heo JD, Lee SJ, Eun HK, Kim GS Abstract AIMS: Present emerging...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase. Metab Brain Dis. 2016 Aug 1; Authors: Rayegan S, Dehpour AR, Sharifi AM Abstract Overproduction of reactive oxygen species (ROS)...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Changing markets - medicinal plants in the markets of La Paz and El Alto, Bolivia. J Ethnopharmacol. 2016 Jul 29; Authors: Bussmann RW, Zambrana NY, Huanca LA, Hart R Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Given the importance of local markets as a source of medicinal plants for both healers...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Implications of Hydrogen Sulfide in Glucose Regulation: How H2S Can Alter Glucose Homeostasis through Metabolic Hormones. Oxid Med Cell Longev. 2016;2016:3285074 Authors: Pichette J, Gagnon J Abstract Diabetes and its comorbidities continue to be a major health problem worldwide. Understanding...
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Novel pharmacological modulators of autophagy: An updated patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug 1; Authors: Ha J, Kim J Abstract INTRODUCTION: Autophagy is a lysosome-dependent degradation pathway that maintains cellular homeostasis in response to a variety of cellular stresses....
08:04
Jaypee Journals by Sfakianakis G. Alexandros
Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin. Oxid Med Cell Longev. 2016;2016:5846865 Authors: Zhou BR, Ma LW, Liu J, Zhang JA, Xu Y, Wu D, Permatasari F, Luo D Abstract Aim. We explored the effects of soy oligopeptides (SOP) in ultraviolet B-...
08:03
Θεραπεία
Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are commonly used in combination with insulin to manage type 2 diabetes mellitus (T2DM), and four agents are currently approved for this indication: exenatide, liraglutide, dulaglutide and albiglutide. The distinctive properties of GLP-1...
08:03
Θεραπεία
Abstract Objectives Primary: To retrospectively review nafcillin plasma concentrations (CNAF) and determine nafcillin clearance (CLNAF) in a diverse sample of patients treated with nafcillin administered as a continuous infusion. Secondary: To identify clinical variables associated with CLNAF and...
07:27
Hearing and Balance
Published Ahead-of-Print The following 15 items were added to...
06:57
Θεραπεία
Abstract Purpose The American Society of Clinical Oncology provides clinical practice guidelines for appropriate cytotoxic chemotherapy dosing for obese adult patients with cancer. The panel recommends that actual body weight should be used when selecting cytotoxic chemotherapy doses regardless of...
06:57
Θεραπεία
Abstract Purpose An attenuated dosing (AD) sunitinib regimen of 37.5 mg daily has been suggested to reduce the toxicity reported with the standard dosing regimen to metastatic renal cell carcinoma (mRCC) patients. The aim of this study was to characterize the population pharmacokinetic (PK) properties...
06:17
OroFacial Medicine by Alexandros G.Sfakianakis
AbstractSulforaphene from cruciferous vegetable has shown to modulate various signaling pathways of apoptosis. But it has not yet been studied extensively for the cervical cancer treatment. Previous studies show the promising role of photodynamic therapy for cervical cancer. Here, we confirm that sulforaphene...
06:17
OroFacial Medicine by Alexandros G.Sfakianakis
AbstractBackgroundMixed dentition space analysis forms an important part of orthodontic diagnosis and treatment planning. Regression equations are widely used for mixed dentition analysis which can vary among races. This study aimed to find out the new regression equation in estimating the size of unerupted...
06:17
OroFacial Medicine by Alexandros G.Sfakianakis
AbstractBackgroundThe repair of alveolar bone defects with growth factors and bone grafting materials has played a pivotal role in modern dentistry. Recombinant human bone morphogenetic protein-2 (rhBMP2), an osteoinductive growth factor capable of cell recruitment and differentiation towards the osteoblast...
05:50
Emergency Medicine by Alexandros G. Sfakianakis
HUNTSVILLE, Ala. — A U.S. Army medic may soon become the next Vietnam War veteran to receive the Medal of Honor.Sgt. Gary Rose, who was the lone medic for a group of Special Forces soldiers sent deep into Laos as part of a secret mission in 1970, was nominated for the nation's highest honor more than...
05:49
Human Diseases
AbstractBackgroundPost-transplant lymphoproliferative disorder (PTLD) adversely affects patients’ long-term outcome.MethodsThe paired t test and McNemar’s test were applied in a retrospective 1:1 matched-pair analysis including 36 patients with PTLD and 36 patients without PTLD after kidney or liver...
05:49
Human Diseases
To determine the proportion of youth within a given body mass index (BMI) obesity category with excess adiposity using dual energy x-ray absorptiometry (DXA). Furthermore, to examine whether mean differences in cardiometabolic risk factors based upon various excess adiposity cutpoints were present.from...
05:49
Human Diseases
A healthy 16-year-old boy with a history of eyelid eczema presented to the emergency department with a lesion on the right eyelid of several weeks' duration (Figure). He denied trauma to the site, recent travel, outdoor exposure, or exposure to animals other than a pet cat. He also denied fever, chills,...
05:49
Human Diseases
AbstractPrenatal psychosocial stressors may increase the risk of wheeze in young offspring, yet little attention has been given to the effects that maternal ethnicity may have on this relationship. From a population-based cohort of 1193 children, we assessed the effect of maternal prenatal stressors...
05:49
Human Diseases
AbstractImmigrant/refugee children sometimes have substantially higher blood lead levels (BLLs) than US-born children in similar environments. We try to understand why, by exploring the relationship between immigration status of mother and the BLLs of US-born children. We compared BLLs of children born...
05:49
Human Diseases
To evaluate the association between Cushing syndrome and hypercoagulability in children.from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2aGQoXi
05:49
Human Diseases
AbstractHPV vaccination rates remain low in the fast growing Latino children population while we continue to observe large HPV-associated cancer disparities in the Latino population. In this study, we sought to elucidate Latino immigrant parents’ barriers to obtaining the HPV vaccine for their children....
05:49
Human Diseases
To analyze associations of short-term exposure to fine particulate matter (diameter ≤ 2.5 µm [PM2.5]), a measurable component of urban pollution, with the event date of fever onset for patients with Kawasaki disease (KD) residing in 7 metropolitan regions.from Pediatrics via xlomafota13 on Inoreader...
05:49
Human Diseases
AbstractMany US Latinos migrate or travel between the US and Mexico on a regular basis, defined as circular migration. Latinos with diabetes (n = 250) were surveyed about circular migration and their ability to use medications and perform recommended diabetes self-care activities. A review of medical...
05:49
Human Diseases
AbstractImmigrants and refugees age 2–14 years entering the United States from countries with estimated tuberculosis (TB) incidence rate ≥20 per 100,000 population are screened for TB. Children with TB disease are treated before US arrival. Children with positive tuberculin skin tests (TST), but negative...
05:49
Human Diseases
To determine if children with benign joint hypermobility (BJH) syndrome and chronic functional pain disorders have more autonomic dysfunction.from Pediatrics via xlomafota13 on Inoreader http://ift.tt/2asMq7v
05:49
Human Diseases
AbstractGuided by the stress process model (SPM), this study investigated the direct and indirect pathways of primary (negative self-image and life stress), secondary stressors (family communication strain) and family coping (external and internal) on mental health outcomes among Chinese- and Korean-American...
05:49
Human Diseases
Coexisting Parkinson's disease (PD) and cervical spondylotic myelopathy (CSM) presents a diagnostic and therapeutic challenge due to symptomatic similarities between diseases. While CSM is routinely treated with surgery, PD patients face poorer outcomes following spine surgery. No studies have investigated...
05:49
Human Diseases
AbstractAll racial/ethnic groups are at higher risk for type 2 diabetes compared to whites, but it is unknown if young adults recognize their risk. Risk knowledge and individual risk perception were examined in 1579 multiracial urban college students. Students have little knowledge of diabetes risk factors;...
05:49
Human Diseases
A 15-year-old, right-hand dominant boy presented tothe emergency department after falling onto hisextended right hand while playing soccer. On physical exam, he had minimal swelling about the wrist, restricted wrist range of motion due to pain, and tenderness to palpation at the anatomic snuff-box (Figure 1;...
08:39
Cancer by Sfakianakis G.Alexandros
Metastatic prostate cancer (PCa) continues to pose a difficult therapeutic challenge. PCa progression is associated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of such events are uncertain. Here we report spontaneous metastasis of human PCa xenografts which...
08:39
Cancer by Sfakianakis G.Alexandros
Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aα scaffold subunit gene PPP2R1A are among the few genomic alterations that occur frequently in serous endometrial carcinoma (EC) and carcinosarcoma, two clinically aggressive subtypes of uterine cancer with few therapeutic options....
08:39
Cancer by Sfakianakis G.Alexandros
Small heterodimer partner (SHP, NR0B2) is a nuclear orphan receptor without endogenous ligands. Due to its crucial inhibitory role in liver cancer, it is of importance to identify small molecule agonists of SHP. As such, we initiated a probe discovery effort to identify compounds capable of modulating...
08:39
Cancer by Sfakianakis G.Alexandros
Macromolecular reagents can be targeted to tumors through active and passive mechanisms. ‘Active’ targeting involves moieties, such as receptor ligands, to direct tumor cell binding, while 'passive’ targeting relies on long reagent circulating half-life, abnormal tumor vasculature, and poor lymphatic...
08:14
Cancer by Sfakianakis Alexandros
Purpose: The MYC oncogene is frequently over-expressed in prostate cancer (PC). Upregulation of ribosome biogenesis and function is characteristic of MYC-driven tumors. Additionally, PIM kinases activate MYC signaling and mRNA translation in PC and cooperate with MYC to accelerate tumorigenesis. Here,...
08:14
Cancer by Sfakianakis Alexandros
Purpose: Therapeutic regimens for ATL are limited with unsatisfactory results, thereby warranting development of novel therapies. This study investigated antitumor activity and toxicity of alemtuzumab with regard to response, duration of response, progression free survival, and overall survival in patients...
08:13
Cancer by Sfakianakis Alexandros
Purpose:We hypothesized that in multiple myeloma cells (MMC), high membrane biosynthesis will induce acetate uptake in vitro and in vivo. Here, we studied acetate metabolism and targeting in MMC in vitro and tested the efficacy of 11C-acetate-PET (positron emission tomography) to detect and quantitatively...
08:13
Cancer by Sfakianakis Alexandros
Purpose: The management of endometrial carcinoma no longer amenable to treatment with surgery or radiation has not improved significantly with modern chemotherapy. Alternative therapeutic options are desperately needed. Experimental Design: We describe 2 heavily pretreated patients with recurrent disease...
08:13
Cancer by Sfakianakis Alexandros
Abstract Purpose The American Society of Clinical Oncology provides clinical practice guidelines for appropriate cytotoxic chemotherapy dosing for obese adult patients with cancer. The panel recommends that actual body weight should be used when selecting cytotoxic chemotherapy doses regardless of...
08:13
Cancer by Sfakianakis Alexandros
Abstract Purpose An attenuated dosing (AD) sunitinib regimen of 37.5 mg daily has been suggested to reduce the toxicity reported with the standard dosing regimen to metastatic renal cell carcinoma (mRCC) patients. The aim of this study was to characterize the population pharmacokinetic (PK) properties...
07:39
Cancer by Sfakianakis G.Alexandros
Purpose: The MYC oncogene is frequently over-expressed in prostate cancer (PC). Upregulation of ribosome biogenesis and function is characteristic of MYC-driven tumors. Additionally, PIM kinases activate MYC signaling and mRNA translation in PC and cooperate with MYC to accelerate tumorigenesis. Here,...
07:39
Cancer by Sfakianakis G.Alexandros
Purpose: Therapeutic regimens for ATL are limited with unsatisfactory results, thereby warranting development of novel therapies. This study investigated antitumor activity and toxicity of alemtuzumab with regard to response, duration of response, progression free survival, and overall survival in...
07:39
Cancer by Sfakianakis G.Alexandros
Purpose:We hypothesized that in multiple myeloma cells (MMC), high membrane biosynthesis will induce acetate uptake in vitro and in vivo. Here, we studied acetate metabolism and targeting in MMC in vitro and tested the efficacy of 11C-acetate-PET (positron emission tomography) to detect and quantitatively...
07:39
Cancer by Sfakianakis G.Alexandros
Purpose: The management of endometrial carcinoma no longer amenable to treatment with surgery or radiation has not improved significantly with modern chemotherapy. Alternative therapeutic options are desperately needed. Experimental Design: We describe 2 heavily pretreated patients with recurrent disease...
02:23
Cancer
Abstract Introduction Fluorescence guidance is an upcoming methodology to improve surgical accuracy. Challenging herein is the identification of the minimum dose at which the tracer can be detected with a clinical-grade fluorescence camera. Using a hybrid tracer such as indocyanine green (ICG)-99mTc-nanocolloid,...
02:23
Cancer
Abstract The EANM 2015 Annual Congress, held from October 10th to 14th in Hamburg, Germany, was outstanding in many respects. With 5550 participants, this was by far the largest European congress concerning nuclear medicine. More than 1750 scientific presentations were submitted, with more than 250...
01:16
Cancer
Abstract Introduction Fluorescence guidance is an upcoming methodology to improve surgical accuracy. Challenging herein is the identification of the minimum dose at which the tracer can be detected with a clinical-grade fluorescence camera. Using a hybrid tracer such as indocyanine green (ICG)-99mTc-nanocolloid,...
01:16
Cancer
Abstract The EANM 2015 Annual Congress, held from October 10th to 14th in Hamburg, Germany, was outstanding in many respects. With 5550 participants, this was by far the largest European congress concerning nuclear medicine. More than 1750 scientific presentations were submitted, with more than 250...
01:16
Cancer
by Zhijuan Lin, Xing Chen, Zhifeng Li, Yiming Luo, Zhihong Fang, Bing Xu, Mingzhe Han Antibodies targeting programmed death 1 (PD-1) help prevent tumor cells from escaping immune-mediated destruction. We conducted this systematic review and meta-analysis to gain insight into the efficacy of PD-1 antibodies...
01:16
Cancer
We report the case of a 37-year-old man with a previous bone marrow transplantation presenting with abdominal pain, diarrhoea and jaundice. Laboratory evaluation showed marked elevated liver enzymes, amylase and lipase with ultrasonographic evidence of acute alithiasic pancreatitis. Liver biopsy was...
01:16
Cancer
Acute abdomen in dengue, a common arboviral disease found in tropical and subtropical countries, is not uncommon and can occasionally present as acute surgical emergency requiring urgent surgical intervention. The spectrum of acute abdomen presenting as surgical emergency in dengue infection that raises...
01:16
Cancer
A 55-year-old woman was admitted to our hospital reporting of nausea, vomiting and anorexia. One month before admission, she had been diagnosed with lung cancer with intestinal metastasis. A CT scan confirmed intussusception due to intestinal metastasis and she underwent emergency laparoscopic surgery...
01:16
Cancer
In 2015, thyroid carcinoma affected approximately 63,000 people in the USA, yet it remains one of the most treatable cancers. It is mainly classified into medullary and non-medullary types. Conventionally, med... from Cases via ola Kala on Inoreader http://ift.tt/2aiX23n via IFTTT
01:16
Cancer
A 19-year-old man with chronic lymphoedema due to Noonan syndrome presented at our hospital with septic shock and pain in his lower leg. Blood cultures were positive for Streptococcus dysgalactiae subsp equisimilis (SDSE), resulting in a diagnosis of cellulitis with toxic involvement. He was treated...
01:16
Cancer
Hemophagocytic lymphohistiocytosis associated with autoimmune diseases is seen in patients with systemic juvenile idiopathic arthritis, adult-onset Still's disease, and systemic lupus erythematosus, whereas it... from Cases via ola Kala on Inoreader http://ift.tt/2aviS6Z via IFTTT
01:16
Cancer
Rift Valley fever (RVF) is a zoonotic disease that primarily affects ruminant animals and can also cause fatal disease in humans. In the current report, we present the ultrastructural changes in the liver of a man aged 60 years who died from RVF in the Aseer Central Hospital, Abha, Saudi Arabia. The...
01:16
Cancer
This is a case report of a 24-year-old Ethiopian woman with a medical history of hepatosplenic schistosomiasis. She suffers from chronic liver failure and portal hypertension. She has been hospitalised for 'hysteria' in the past but did not receive follow-up, outpatient treatment or psychiatric evaluation....
Tue Aug 02, 2016 21:19
Cancer
Abstract Background Cell-penetrating peptides (CPPs) are a research hotspot due to their noninvasive delivery ability. Among the identified CPPs, the TAT and R8 peptides have been preferentially applied to transduction into different cells. However, this process is nonselective among various cells....
Tue Aug 02, 2016 21:19
Cancer
Abstract Background The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling...
Tue Aug 02, 2016 21:19
Cancer
Abstract Background Prostate cancer is one of the most common male cancers worldwide. Active Surveillance (AS) has been developed to allow men with lower risk disease to postpone or avoid the adverse side effects associated with curative treatments until the disease progresses. Despite the medical...
Tue Aug 02, 2016 21:19
Cancer
Abstract Background The role of microRNA-200 (miR-200) family members in the migration and invasion of breast cancer is controversial. This study investigated the mechanisms by which the miR-200 family members modulated the migratory and invasive abilities of an aggressive triple-negative breast cancer...
Tue Aug 02, 2016 20:42
Cancer by Sfakianakis Alexandros
Abstract Background Cell-penetrating peptides (CPPs) are a research hotspot due to their noninvasive delivery ability. Among the identified CPPs, the TAT and R8 peptides have been preferentially applied to transduction into different cells. However, this process is nonselective among various cells....
Tue Aug 02, 2016 20:42
Cancer by Sfakianakis Alexandros
Abstract Background The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling...
Tue Aug 02, 2016 20:42
Cancer by Sfakianakis Alexandros
Abstract Background Prostate cancer is one of the most common male cancers worldwide. Active Surveillance (AS) has been developed to allow men with lower risk disease to postpone or avoid the adverse side effects associated with curative treatments until the disease progresses. Despite the medical...
Tue Aug 02, 2016 20:41
Cancer by Sfakianakis Alexandros
Abstract Background The role of microRNA-200 (miR-200) family members in the migration and invasion of breast cancer is controversial. This study investigated the mechanisms by which the miR-200 family members modulated the migratory and invasive abilities of an aggressive triple-negative breast cancer...
Tue Aug 02, 2016 20:41
Cancer by Sfakianakis Alexandros
Abstract Background We report the re-biopsied diagnosis of a patient with anaplastic lymphoma receptor tyrosine kinase (ALK)-positive lung adenocarcinoma successfully treated with ceritinib 450 mg/day taken with food following disease progression and gastrointestinal intolerance to crizotinib. Case...
Tue Aug 02, 2016 20:41
Cancer by Sfakianakis Alexandros
Abstract Background Fibronectin is a mechanically sensitive protein which is organized in the extracellular matrix as a network of interacting fibrils. The lung tumor stroma is enriched for fibronectin which is thought to contribute to metastasis and drug resistance. Fibronectin is an elastic, multi-modular...
Tue Aug 02, 2016 20:41
Cancer by Sfakianakis Alexandros
Abstract Background Many factors contribute to socioeconomic status (SES), yet in most survival studies only income is used as a measure for determining SES. We used a complex, composite, census-based metric for socioeconomic deprivation to better distinguish individuals with lower SES and assess its...
Tue Aug 02, 2016 20:41
Cancer by Sfakianakis Alexandros
Abstract Background Volume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response in nonsmall cell lung cancer (NSCLC). We aimed to examine intra- and...
Tue Aug 02, 2016 20:24
Cancer by Sfakianakis Alexandros
from Cancer via ola Kala on Inoreader http://ift.tt/2b0eOts via IFTTT
Tue Aug 02, 2016 20:24
Cancer by Sfakianakis Alexandros
from Cancer via ola Kala on Inoreader http://ift.tt/2afF5Hh via IFTTT
Tue Aug 02, 2016 20:24
Cancer by Sfakianakis Alexandros
Abstract Background The aim of this study was to analyze the influence of volumetric changes of bladder and rectum filling on the 3D dose distribution in prostate cancer radiotherapy. Methods A total of 314 cone-beam CT (CBCT) image data sets from 19 patients were enrolled in this study. For each...
Tue Aug 02, 2016 19:50
Cancer by Sfakianakis Alexandros
Abstract Purpose Recently, segmentectomy has been considered as an alternative to lobectomy in early peripheral non-small lung cancer (NSCLC); however, controversy has remained regarding the long-term functional advantage after segmentectomy. The aim of this study was to analyze the postoperative lung...
Tue Aug 02, 2016 19:50
Cancer by Sfakianakis Alexandros
Abstract Purpose Mesenchymal stem cells (MSCs) suppress inflammation and immune responses. We conducted this study to find out if MSCs attenuate ischemia–reperfusion injury in a mouse model of lung transplantation. Methods C57BL/6J mouse lungs perfused with low-potassium dextran glucose solution...
Tue Aug 02, 2016 19:50
Cancer by Sfakianakis Alexandros
The aim of this study was to analyze the influence of volumetric changes of bladder and rectum filling on the 3D dose distribution in prostate cancer radiotherapy. from Cancer via ola Kala on Inoreader http://ift.tt/2aMGOVl via IFTTT
Tue Aug 02, 2016 19:50
Cancer by Sfakianakis Alexandros
Re-irradiation (re-RT) of the thorax is challenging due to the impact of prior therapies on normal tissues, and there are few reports of definitive re-RT. The treatment toxicities and efficacy of re-RT are not... from Cancer via ola Kala on Inoreader http://ift.tt/2aypEGE via IFTTT
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