08:45
Oncology
Purpose:UGT1A1*28 confers a higher risk of toxicity in patients treated with irinotecan. Patients with *1/*1 and *1/*28 genotypes might tolerate higher than standard doses of irinotecan. We aimed to identify the maximum tolerated dose (MTD) of irinotecan in mCRC patients with *1/*1 and *1/*28 genotypes...
08:45
Oncology
Purpose:Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell lung cancer (SCLC), little is known about its molecular features. We analyzed lung LCNECs to identify biologically relevant genomic alterations. Experimental Design:We performed...
08:45
Oncology
Purpose:Endometrial cancer (EC) is a common gynecological cancer whose incidence is increasing annually worldwide. Current methods to detect EC are unreliable and biomarkers are unsatisfactory for screening. Cervical scrapings were reported as a potential source of material for molecular testing. DNA...
08:44
medicinealexandrossfakianakis
Risk factors for sepsis in Korean trauma patients: Abstract Purpose Sepsis in severely injured patients is one of the leading causes of death in hospitals. The incidence of and risk factors for sepsis after trauma have been studied outside, but not within Korea. Therefore, this study investigated...
08:44
medicinealexandrossfakianakis
Are retrievable vena cava filters placed in trauma patients really retrievable?: Abstract Purpose Concerns have arisen regarding the use of retrievable inferior vena cava filters (rIVCFs) in trauma patients due to increasing reports of low retrieval rates. We hypothesized that complete follow-up...
08:44
medicinealexandrossfakianakis
outcome differences between southern Finland and Germany—lesson learned from trauma-registry comparisons: Abstract Purpose International trauma registry comparisons are scarce and lack standardised methodology. Recently, we performed a 6-year comparison between southern Finland and Germany. Because...
08:43
medicinealexandrossfakianakis
Simple scoring system for prediction of mortality in Fournier’s gangrene: Abstract Purpose To create new scoring system for prediction of hospital mortality for patients with Fournier’s gangrene(FG). Material and method In total, 84 patients with FG were enrolled into this study. The demographic...
08:43
Medicine by Sfakianakis G. Alexandros
The Frankfurt plane or Frankfort plane (both spellings are widely used, and the term is entered as Frankfort horizontal plane in several medical dictionaries, although Frankfurt is the modern standard spelling of the city it is named for) was established at the World Congress on Anthropology in Frankfurt am...
08:42
Medicine by Sfakianakis G. Alexandros
Abstract Oropharyngeal dysphagia (OD) is a prevalent geriatric syndrome. Treatment is based on compensatory strategies to avoid complications. New treatments based on sensory stimulation to promote the recovery of the swallowing function have proved effective in acute studies but prolonged treatment...
08:42
Medicine by Sfakianakis G. Alexandros
Publication date: Available online 9 August 2016Source:Journal of Allergy and Clinical Immunology Author(s): Mattias Levin, Fredrik Levander, Robert Palmason, Lennart Greiff, Mats Ohlin IgE encoded by cells in bone marrow are more diverse than those encoded by cells in peripheral blood. IgE repertoires...
08:42
Medicine by Sfakianakis G. Alexandros
Approximately 45% of patients with asthma in the United Kingdom are receiving step 3 or higher therapy,1 most commonly inhaled corticosteroids (ICSs) and long-acting β2-agonists (LABAs). The 2016 Global Initiative for Asthma (GINA) guidelines propose a cycle of assessment, stepwise adjustment of treatment,...
08:42
Medicine by Sfakianakis G. Alexandros
Botulinum toxin (BTX) has been widely used to treat adductor spasmodic dysphonia (ADSD). Most commercially available forms of BTX require reconstitution before use, which may increase the risk of contamination and requires careful titration. Recently, a liquid-type BTX type A (BTX-A) has been developed,...
08:42
Medicine by Sfakianakis G. Alexandros
Related Articles Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice. Ann Otol Rhinol Laryngol. 2016 Apr;125(4):290-6 Authors: Hua X, Naselsky WC, Jania CM, Chason KD, Huang JJ, Doerschuk CM, Graham SM, Senior BA, Tilley SL Abstract BACKGROUND: Chronic rhinosinusitis...
08:42
Medicine by Sfakianakis G. Alexandros
Related Articles Surgery or Rehabilitation: A Randomized Clinical Trial Comparing the Treatment of Vocal Fold Polyps via Phonosurgery and Traditional Voice Therapy with "Voice Therapy Expulsion" Training. J Voice. 2016 Aug 2; Authors: Barillari MR, Volpe U, Mirra G, Giugliano F, Barillari U Abstract...
08:42
Medicine by Sfakianakis G. Alexandros
. http://ift.tt/2bhWr3j
08:42
Medicine by Sfakianakis G. Alexandros
Surgical treatment of the medication-related osteonecrosis of the jaw (MRONJ) is still challenging. We examined the outcome of the resection of osteonecrotic lesions and the influence of potential risk factors on the operative success. http://ift.tt/2aJ47tB
08:42
Medicine by Sfakianakis G. Alexandros
. http://ift.tt/2b7b3X8
08:42
Medicine by Sfakianakis G. Alexandros
Publication date: November 2016Source:Brain and Language, Volume 162 Author(s): P.J. López-Peréz, J. Dampuré, J.A. Hernández-Cabrera, H.A. Barber During reading parafoveal information can affect the processing of the word currently fixated (parafovea-on-fovea effect) and words perceived parafoveally...
08:42
Medicine by Sfakianakis G. Alexandros
Publication date: Available online 9 August 2016Source:Cortex Author(s): John Towler, Martin Eimer It is often assumed that upright faces are represented in a holistic fashion, while representations of inverted faces are essentially part-based. To assess this hypothesis, we recorded event-related...
08:42
Medicine by Sfakianakis G. Alexandros
Objective: To investigate 5-year speech and language outcomes in children with cleft lip/palate (CLP).Materials and methods: Thirty-eight children aged 4-7 years and 8 months were recruited for this study. Speech abilities including articulation, resonance, voice, and intelligibility were assessed based...
08:42
Medicine by Sfakianakis G. Alexandros
Publication date: Available online 9 August 2016Source:Cancer/Radiothérapie Author(s): M. Lapeyre, J. Biau, S. Racadot, J.F. Moreira, L. Berger, D. Peiffert La radiothérapie conformationnelle avec modulation d'intensité (RCMI) et la curiethérapie font parties des techniques d'irradiation de référence...
08:42
Medicine by Sfakianakis G. Alexandros
Pregnenolone sulfate (PS) is a neuroactive steroid hormone produced in the brain. In this study, the effects of PS on synthesis and secretion of rat pituitary prolactin (PRL) were examined. To accomplish this, GH3 rat pituitary adenoma cells were treated with PS, which showed significantly increased...
08:42
Medicine by Sfakianakis G. Alexandros
Objective Persistent dysphonia from vocal fold scar remains a clinical challenge, with current therapies providing inconsistent outcomes. We evaluated voice outcomes after a single office-based steroid injection. Study Design Case series with chart review. Setting Academic medical center. Subjects...
08:42
Medicine by Sfakianakis G. Alexandros
Abstract The six-food elimination diet (SFED), where dairy, wheat, eggs, soy, nuts, and seafood are avoided, is an effective treatment for eosinophilic esophagitis (EoE). Patient-related costs of this approach, however, are unknown. We aimed to assess the cost of and ease of shopping for an SFED compared...
08:42
Medicine by Sfakianakis G. Alexandros
Surgery for sagittal synostosis aims at correction of skull shape and restoration of growth potential. Small cranial volume is associated with raised intracranial pressure (ICP). Although many techniques have been described, information on postoperative volume related to early and late remodeling is...
08:42
Medicine by Sfakianakis G. Alexandros
Publication date: Available online 9 August 2016Source:Cancer/Radiothérapie Author(s): P. Maingon, P. Giraud, Y. Pointreau La radiothérapie, avec ou sans chimiothérapie ou thérapie ciblée, nécessite une préparation du malade rigoureuse, parfois complexe, souvent chronophage, mais indispensable pour...
08:42
Medicine by Sfakianakis G. Alexandros
Publication date: Available online 9 August 2016Source:Cancer/Radiothérapie Author(s): L. Feuvret, D. Antoni, J. Biau, G. Truc, G. Noël, J.-J. Mazeron Les gliomes sont les tumeurs cérébrales primitives de l'adulte les plus fréquentes. Leur traitement est difficile en raison de la proximité des organes...
08:42
Medicine by Sfakianakis G. Alexandros
Abstract Objective To study: i) the diversity of the natural colour of the human hair through both visual assessment of Hair Tone levels and colorimetric measurements of hair strands collected from 2057 human male and female volunteers, from 23 regions of the world and ii) the correlation between...
08:42
Medicine by Sfakianakis G. Alexandros
Abstract Objective Worldwide, individuals apply deodorants to combat malodor formation originating from the axillary vault. Considering the globally increasing demand for efficacious, safe deodorants, we investigated the antimicrobial effectiveness of a polymeric quaternary ammonium (PQ-16) compound...
08:42
Medicine by Sfakianakis G. Alexandros
Publication date: Available online 9 August 2016Source:Journal of Allergy and Clinical Immunology Author(s): Robyn T. Cohen, Mark Rodeghier, Fenella J. Kirkham, Carol L. Rosen, Jane Kirkby, Michael R. DeBaun, Robert C. Strunk BackgroundSignificance of exhaled nitric oxide (FeNO) levels in children...
08:42
Medicine by Sfakianakis G. Alexandros
Histamine-induced wheals and flares induced by skin prick tests (SPTs) may be used beyond the typical clinical setting as pharmacodynamic markers in clinical trials. The wheal and flare areas may be measured at multiple time points and an area under the curve calculated to quantify the reaction during...
08:42
Medicine by Sfakianakis G. Alexandros
Abstract Phosphatase and tensin homologue (PTEN) is a known tumour suppressor. To explore the role of Pten in ovarian tumorigenesis, we used transgenic (Tg) SOX2. Cre and AMH. Cre mouse models to direct global Pten haploinsufficiency (Pten +/−) or ovary-specific granulosa cell (GC) Pten disruption (Pten...
08:42
Medicine by Sfakianakis G. Alexandros
Higher FeNO levels were not associated with prior morbidity, asthma, respiratory symptoms, or airway obstruction but were associated with features of atopy and prospective rate of ACS in children with sickle cell anemia. http://ift.tt/2aKeYXt
08:41
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Summary BackgroundMale pattern baldness, or androgenetic alopecia, affects approximately 50% of the adult population and can cause poor self-image, low self-esteem and have a significant negative impact on the quality of life. An oral nutraceutical supplement based on a marine complex formulation has...
08:41
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Abstract Background Infratentorial supracerebellar approach via microscope still has some limitations in resection of pineal region tumors. Methods The...
08:41
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Geobacter sulfurreducens is an anaerobic soil bacterium that is involved in biogeochemical cycles of elements such as Fe and Mn. Although significant progress has been made in the understanding of the electron transfer processes in G. sulfurreducens, little is known about the regulatory mechanisms involved...
08:41
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
There are not only many links between microbiological and philosophical topics, but good educational reasons for microbiologists to explore the philosophical issues in their fields. I examine three broad issues of classification, causality and model systems, showing how these philosophical dimensions...
08:41
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
from Dermatology via xlomafota13 on Inoreader http://ift.tt/2aKGkN4
08:41
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Aquaporins (Aqps) are expressed within key osmoregulatory tissues where they mediate the movement of water and selected solutes across cell membranes. We leveraged the functional plasticity of Mozambique tilapia (Oreochromis mossambicus) gill epithelium to examine how Aqp3, an aquaglyceroporin, is regulated...
08:41
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Pregnenolone sulfate (PS) is a neuroactive steroid hormone produced in the brain. In this study, the effects of PS on synthesis and secretion of rat pituitary prolactin (PRL) were examined. To accomplish this, GH3 rat pituitary adenoma cells were treated with PS, which showed significantly increased...
08:41
Medicine by Sfakianakis G. Alexandros
Background: Alpha-glucosidase is the key enzyme involved in catalyzing the carbohydrate alpha-glucosidase through hydrolysis. It is implicated in several metabolic pathways, including carbohydrate digestion in the intestine, and glycoprotein and glycolipid processing. Alpha-glucosidase inhibitors are...
08:41
Medicine by Sfakianakis G. Alexandros
Background: A fast and reliable method for the quantification of ursodeoxycholic acid (UDCA) in hepatic function medicines was developed. </P><P> Objective: To develop and validate a simple cleanup procedure based on a solid-phase extraction using an OASIS HLB cartridge for extracting ursodeoxycholic...
08:41
Medicine by Sfakianakis G. Alexandros
Background: Diseases of cardio, as well as the cerebrovascular system, are known as the primary possibility for deficits in cognitive processes and dementia of vascular nature. Endothelin-1 (ET-1) and its receptors are extensively expressed in brain. </p> <p> Objective: The present study...
08:41
Medicine by Sfakianakis G. Alexandros
Alterations of enzymes linked to arginine metabolism have been recently implicated in Alzheimer's disease (AD). Despite strong association of arginine changes with nitric oxide (NO) pathway, the impact of amyloid β (Aβ) peptides on arginine degradation and re-synthesis is unknown. In the present study...
08:41
Medicine by Sfakianakis G. Alexandros
The research of circulating tumor cells (CTCs) has drawn much attention in recent years. It is because of the potential values of CTCs in early diagnosis of cancer, management of clinical treatment, exploration of metastatic mechanism, and development of personalized medicine. However, isolating CTCs...
08:41
Medicine by Sfakianakis G. Alexandros
Epidemiological evidences establish sulforaphane (SFN), a hormetic dietary isothiocyanate to be a promising chemopreventive, anti-inflammatory and anti-cancer agent. Beyond a concentration threshold SFN exerts pro-death activities (cell cycle arrest, epigenetic modifications and apoptosis) and below...
08:41
Medicine by Sfakianakis G. Alexandros
Background: Most drugs exert their biological and physiological effects via binding to protein targets. Although drugs are traditionally optimized against a single protein, most marketed drugs exhibit clinically relevant polypharmacology – the activity of drugs at multiple targets. The wide-spread presence...
08:41
Medicine by Sfakianakis G. Alexandros
Volatile organic compounds (VOCs) offer unique insights into ongoing biochemical processes in healthy and diseased humans. Yet, their diagnostic use is hampered by the limited understanding of their biochemical or cellular origin and their frequently unclear link to the underlying diseases. Major advancements...
08:41
Medicine by Sfakianakis G. Alexandros
We investigated the in vitro effects of guaraná and its main metabolites (caffeine, theobromine and catechin) on cytotoxicity and cell proliferation on colorectal cancer (CRC) line HT-29 cells and on oxaliplatin sensitivity. The cells were exposed to different concentrations of guaraná extract with and...
08:41
Medicine by Sfakianakis G. Alexandros
Pregnenolone sulfate (PS) is a neuroactive steroid hormone produced in the brain. In this study, the effects of PS on synthesis and secretion of rat pituitary prolactin (PRL) were examined. To accomplish this, GH3 rat pituitary adenoma cells were treated with PS, which showed significantly increased...
08:41
Medicine by Sfakianakis G. Alexandros
Abstract Objective To study: i) the diversity of the natural colour of the human hair through both visual assessment of Hair Tone levels and colorimetric measurements of hair strands collected from 2057 human male and female volunteers, from 23 regions of the world and ii) the correlation between...
08:41
Medicine by Sfakianakis G. Alexandros
Abstract Objective Worldwide, individuals apply deodorants to combat malodor formation originating from the axillary vault. Considering the globally increasing demand for efficacious, safe deodorants, we investigated the antimicrobial effectiveness of a polymeric quaternary ammonium (PQ-16) compound...
08:41
Medicine by Sfakianakis G. Alexandros
Publication date: Available online 9 August 2016Source:Cortex Author(s): John Towler, Martin Eimer It is often assumed that upright faces are represented in a holistic fashion, while representations of inverted faces are essentially part-based. To assess this hypothesis, we recorded event-related potentials...
08:41
Medicine by Sfakianakis G. Alexandros
Rhabdomyosarcoma (RMS) is the most frequent pediatric soft-tissue tumor accounting for about 7% of childhood malignancies. Multimodal therapy is the standard treatment for individuals with RMS but generally fails to cure high-risk group patients and can result in long-term side effects. Therefore, understanding...
08:41
Medicine by Sfakianakis G. Alexandros
A chromosomal microdeletion at the 22q11.2 locus is associated with extensive cognitive impairments, schizophrenia and other psychopathology in humans. Previous reports indicate that mouse models of the 22q11.2 microdeletion syndrome (22q11.2DS) may model the genetic basis of cognitive deficits relevant...
08:41
Medicine by Sfakianakis G. Alexandros
Aquaporins (Aqps) are expressed within key osmoregulatory tissues where they mediate the movement of water and selected solutes across cell membranes. We leveraged the functional plasticity of Mozambique tilapia (Oreochromis mossambicus) gill epithelium to examine how Aqp3, an aquaglyceroporin, is regulated...
08:41
Medicine by Sfakianakis G. Alexandros
Abstract Phosphatase and tensin homologue (PTEN) is a known tumour suppressor. To explore the role of Pten in ovarian tumorigenesis, we used transgenic (Tg) SOX2. Cre and AMH. Cre mouse models to direct global Pten haploinsufficiency (Pten +/−) or ovary-specific granulosa cell (GC) Pten disruption (Pten...
08:41
Medicine by Sfakianakis G. Alexandros
Bone marrow mesenchymal stem cells (BMSCs) have a therapeutic role in retinal degeneration (RD). However, heterogeneity of BMSCs may be associated with differential therapeutic effects in RD. In order to confirm this hypothesis, two subsets of rat BMSCs, termed rBMSC1 and rBMSC2, were obtained, characterized...
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