Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: A preliminary study

Abstract

Background

Glypican-3 is a cell suface proteoglycan that is found in embrionary tissues and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was investigate glypican-3 in a series of agressive and non-aggressive odontogenic tumors.

Methods

Fifty-nine cases of tumors were divided into aggressive odontogenic tumors (20 solid ameloblastomas, 4 unicystic ameloblastoma, 28 KOTs including 5 associated with Gorlin-Goltz syndrome) and non-aggressive odontogenic tumors (5 adenomatoid odontogenic tumors, and 2 calcifying cystic odontogenic tumors) and analyzed for glypican-3 using immunohistochemistry.

Results

Glypican-3 was observed in seven solid ameloblastoma and eighteen keratocystic odontogenic tumor including three of the five syndromic cases, but there was no significant difference between syndromic and sporadic cases (p>0,05; Fisher's exact Test). All cases of unicystic ameloblastoma (n=4), adenomatoid odontogenic tumor (n=5) and calcifying cystic odontogenic tumor (n=2) were negative.

Conclusions

This provided insights into the presence of glypican-3 in odontogenic tumors. This protein distinguished aggressive from non-aggressive odontogenic tumors.

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