Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Σάββατο 3 Σεπτεμβρίου 2016

Non-cannibalistic tumor cells of oral squamous cell carcinoma can express phagocytic markers

Abstract

Background

CD68 and lysozyme expression in cannibalistic tumor cells of oral squamous cell carcinoma (OSCC) is well established. Transformation of cancer cells into cannibalistic cells is a process involving sequential events. Initial event could be genetic expression of proteins that is required for execution of cannibalism. Hence, it is quite possible that some non-cannibalistic tumor cells can also show expression of cannibalistic markers (CD68 and lysozyme).

Methodology

Formalin fixed tissue of 30 OSCC with cellular cannibalism (CC) (positive control), 30 OSCC without CC and 17 normal oral epithelium specimens (negative control) were subjected to immunohistochemical analysis for CD68 and lysozyme expression.

Results

OSCC with CC showed CD68 and lysozyme expression in 30 (100%) cases each [CD68: (weak: 21 (70%), strong: 9 (30%); lysozyme: (weak: 24 (80%), strong: 6 (20%)]. In OSCC without CC, CD68 positive tumor cells were present in 13 (43.33%) cases [(weak: 10 (33.33%); strong: 3 (10%)] and lysozyme expression was present in 13 (43.33%) cases [(weak: 12 (40%); strong: 1 (3.33%)]. Control group showed negative expression for CD68 and lysozyme in the oral epithelium. The CD68 and lysozyme expression in OSCC without CC, OSCC with CC and control group showed statistically significant differences (p < 0.001). Significant correlation was also observed between CD68 and lysozyme expression and different grades of OSCC.

Conclusion

CD68 and lysozyme expression in non-cannibalistic tumor cells of OSCC can be related to CC.

This article is protected by copyright. All rights reserved.



http://ift.tt/2c2hatB

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου