Cross-Talk between Human Mast Cells and Epithelial Cells by IgE-mediated Periostin Production in Eosinophilic Nasal Polyps

Publication date: Available online 19 October 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Dae Woo Kim, Marianna Kulka, Ara Jo, Kyoung Mi Eun, Narcy Arizmendi, Brian P. Tancowny, Seung-No Hong, Jung Pyo Lee, Hong Ryul Jin, Richard F. Lockey, Dong-Kyu Kim, Seong H. Cho

Teaser

Periostin is up-regulated in E-NP and is associated with disease severity and Th2 inflammatory markers. Periostin was produced by IgE-stimulated mast cells. Secreted periostin binds to integrin αV on the epithelial cell surface and induces TSLP release from epithelial cells in E-NP.


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