Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in severe asthma

Publication date: Available online 5 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Milena Sokolowska, Li-Yuan Chen, Yueqin Liu, Asuncion Martinez-Anton, Carolea Logun, Sara Alsaaty, Rosemarie A. Cuento, Rongman Cai, Junfeng Sun, Oswald Quehenberger, Aaron M. Armando, Edward A. Dennis, Stewart J. Levine, James H. Shelhamer

Teaser

Through lipidomics and transcriptomics, we demonstrated that fragmented hyaluronan increases production of several lipids in severe asthmatics, which correlates with decreases in antiviral gene and protein expression; effect partially reversed upon inhibition of lipid production.


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