N-RAS expression in patients with salivary adenoid cystic carcinoma: association with clinicopathological features and prognosis

Publication date: Available online 2 November 2016
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Jiuling Yue, Xiaonan Liu, Shanshan Zhuo, Wenchao Zhang
ObjectiveThe aim of this study was to investigate N-RAS expression in patients with salivary adenoid cystic carcinoma (SACC) and to analyze its association with clinicopathological features and prognosis.Study DesignWe determined N-RAS expression in SACC tumors via immunohistochemistry and evaluated the association between N-RAS expression and clinicopathological variables. The disease-free survival curves were plotted using the Kaplan-Meier method. The parameters of prognostic significance found by univariate analysis were tested by a multivariate Cox regression model.ResultsN-RAS expression was detected in 61 of 72 (84.7%) SACC tumor samples. In univariate analyses, N-RAS expression was associated with clinical stage, tumor size, adjacent tissue invasion and distant metastasis. N-RAS expression was associated with disease-free survival in univariate analysis, however in multivariate analysis N-RAS was not an independent prognostic indicator, but clinical stage (0.04) and histological subtype (0.02) were statistically significant.ConclusionOur data suggests that N-RAS was overexpressed in SACC tissues, but not an independent prognostic indicator of disease-free survival. Only clinical stage and histological subtype were prognostic indicators of disease-free survival.



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