ORMDL3 transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide

Publication date: Available online 5 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Marina Miller, Peter Rosenthal, Andrew Beppu, Ruth Gordillo, David H. Broide

Teaser

ORMDL3 is highly linked to asthma in genetic association studies. Mice with increased human ORMDL3 expression have reduced levels of sphingolipids. ORMDL3 regulation of sphingolipid levels may play a role in the pathogenesis of asthma.


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