Assessment of EGF receptor ligand expression in gastric carcinoma and in lesional skin of paraneoplastic acanthosis nigricans: A case report

Abstract

A 70-year-old male presented with hyperpigmentation and thickening of the skin, especially on the neck, axillae and groin, papillomatous thickening of the mucosa of the mouth and lips which presented a "stone path-like" morphology and cutaneous and palmoplantar thickening with marked accentuation of skin dermatoglyphic patterns ("tripe-palms") (Fig 1). The lesions had started one year previously and were accompanied by generalized pruritus, intense asthenia on mild exertion and weight loss.

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