Unusual scrotal and penile ulcerations together with palmar-plantar erythrodysesthesia syndrome in a patient with metastatic colon carcinoma treated with capecitabine

Abstract

Capecitabine is an orally administered chemotherapeutic drug used in the treatment of colorectal and breast cancer, as well as of metastatic disease, either as a single agent or combined with other agents (1). A 63 -year-old man presented with painful penile and scrotal ulcerations (Figure 1). Four years prior to admission, the patient underwent ileocecal resection for cecum cancer (pT3, N1, M0, Duke's C) with metastases in the mesocolic lymph nodes. He received 6 cycles of Mayo Clinic adjuvant regimen consisting of 5-fluorouracil (5-FU) and leucovorin (folinic acid).

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