Prognostic factors in malignant sublingual salivary gland tumors

Publication date: Available online 18 December 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Yanbin Liu, Hong Li, Lizheng Qin, Xin Huang, Ming Su, Zhengxue Han
PurposeThis study identified the prognostic factors and outcomes for malignant sublingual salivary gland tumors, which are rare.Materials and MethodsRetrospective cohort study of patients treated for malignant sublingual salivary gland tumors from 1997 to 2011 was performed. Predictor variables, including age, gender, tumor stage, nodal stage, perineural invasion, margin status, and lymphovascular invasion, were analyzed. Cox regression model was used to determine the prognostic factors for local-regional recurrence, distant metastasis, and survival.ResultsAmong 38 patients, 16 (42.1%) were male. Mean age was 53 years (range: 36–75). A total of 11 (28.9%) patients had T3–4 tumors, and 6 (15.8%) had positive neck lymph nodes. The recurrence rate at 5 years was 18.4%. The distant metastasis rate at 5 years was 23.7%. Multivariable analysis confirmed the independent prognostic importance of the age, N stage, and limited tongue mobility in local-regional recurrence and mortality at 5 years.ConclusionsOur results suggested that age, N stage, and limited tongue mobility are useful as independent predictors of local-regional recurrence and mortality in patients with malignant sublingual salivary gland tumors.



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