Substance P activates Mas-related G-protein coupled receptors to induce itch

Publication date: Available online 20 February 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Ehsan Azimi, Vemuri B. Reddy, Paula Juliana Seadi Pereira, Sebastien Talbot, Clifford J. Woolf, Ethan A. Lerner
BackgroundSubstance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1.ObjectiveBecause Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs.MethodsGenetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice.ResultsSP-induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK-1R.ConclusionWe deduce that SP activates MrgprA1 on sensory neurons rather than NK-1R to induce itch.



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